Particles for nourishing and clearing heat from throat as well as preparation method and application of particles

Abstract

The invention discloses a throat nourishing and clearing granule as well as a preparation method and application thereof, and belongs to the field of pharmaceutical preparations, the throat nourishing and clearing granule comprises the following components in parts by weight: 10-20 parts of radix rehmanniae recen, 10-20 parts of radix ophiopogonis, 10-20 parts of radix paeoniae alba, 5-15 parts of moutan bark, 5-15 parts of thunberg fritillary bulb, 10-20 parts of radix scrophulariae and 5-15 parts of lily; the preparation method comprises the following steps: S1, preparing raw materials; s2, crushing; s3, mixing; s4, performing granulation; s5, drying; s6, screening to obtain prepared particles; the granules for nourishing and clearing heat from throat provided by the invention can nourish yin and clear heat, remove stasis and relieve sore throat, relieve symptoms such as throat pain, dry mouth and pharynx, throat itching, foreign body sensation of throat and the like, have a good clinical curative effect and few side effects, and are especially suitable for yin deficiency and lung heat patients with chronic pharyngolaryngitis delayed and unhealed, recurrent attack, dry oropharynx, dysphoria in both heart and heart, dry cough without phlegm, less and sticky phlegm and the like.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical preparations, and in particular to a throat nourishing and throat clearing granule and a preparation method and application thereof. Background Art

[0002] Chronic pharyngitis is a chronic inflammatory disease that is prone to occur in the pharyngeal mucosa, submucosa and surrounding lymphoid tissue. The main symptoms are dry and itchy throat, and a foreign body sensation in the throat, with or without sticky phlegm that is difficult to cough up and difficulty swallowing. Due to factors such as the deterioration of urban air quality, abuse of antibiotics and poor eating habits, the prevalence of chronic pharyngitis has accounted for about 1 / 3 of otolaryngology diseases. Traditional Chinese medicine calls it "chronic laryngitis". Traditional Chinese medicine believes that chronic laryngitis is mostly caused by lung and kidney yin deficiency, spleen qi deficiency, spleen and kidney yang deficiency, phlegm coagulation and blood stasis. From the clinical data, yin deficiency type pharyngitis is the most common, followed by phlegm coagulation and blood stasis type, while yang deficiency and qi deficiency types are relatively rare.

[0003] Modern medicine treats chronic pharyngitis mainly with oral antibiotics, nebulized glucocorticoids and other drugs. Although they can temporarily relieve the patient's discomfort, long-term nebulized inhalation has the risk of local fungal infection and drug resistance, and the disease is very easy to recur. Most patients are chronic and have a long treatment cycle, which brings considerable psychological pressure to patients and greatly affects their quality of life. Traditional Chinese medicine is widely used in the treatment of pharyngitis and has a high degree of social recognition. However, currently Chinese herbal preparations are mostly concentrated on wind-heat, phlegm-heat and other syndromes, and most of them are bitter and cold and damage body fluid, which aggravates the symptoms. Yangyin Qingfei Decoction is a classic prescription for nourishing yin and clearing the lungs in the field of traditional Chinese medicine. It has good effects of nourishing yin and clearing the lungs, detoxifying and relieving sore throat. It has a practical effect in the clinical treatment of chronic laryngeal arthritis, and is often combined with nebulized inhalation treatment to improve patients' immune function and relieve inflammatory response. It has good clinical application value. Summary of the invention

[0004] The present invention is intended to provide a throat nourishing and clearing granule and a preparation method and application thereof, so as to solve the problems raised in the above background technology.

[0005] In order to achieve the above object, the present invention provides the following technical solutions:

[0006] A throat nourishing and clearing granule and a preparation method thereof, comprising the following components by weight: 10-20 parts of raw rehmannia root, 10-20 parts of ophiopogon japonicus, 10-20 parts of white peony root, 5-15 parts of moutan bark, 5-15 parts of thunbergii bulb, 10-20 parts of scrophularia ningpoensis, and 5-15 parts of lily;

[0007] The preparation method comprises:

[0008] S1. Raw material preparation: Take Radix Rehmanniae, Radix Ophiopogonis, White Peony Root, Cortex Moutan, Fritillaria Thunbergii, Scrophulariae, and Lilium respectively, weigh them, clean them and remove impurities for subsequent processing;

[0009] S2. Crushing: Grind the medicinal materials into fine and uniform powder;

[0010] S3, mixing: mixing different medicinal materials in a fixed proportion to ensure that the ingredients of the medicinal materials are evenly distributed;

[0011] S4, granulation: add appropriate amount of auxiliary materials and appropriate amount of water to the mixed medicinal materials, spray the mixture with water, and stir until it forms a mass;

[0012] S5, drying: drying the obtained particles, and using vacuum drying to reduce the moisture content of the particles;

[0013] S6. Screening: Screen the dried particles to remove unqualified particles, screen out the required particle size, make the particle size uniform, and obtain the prepared particles.

[0014] Preferably, the Yangyan Qingyan granules are used for treating throat discomforts such as sore throat, dry mouth and throat, itchy throat, etc. caused by yin deficiency and internal heat, and chronic pharyngitis with the above symptoms.

[0015] Preferably, the pharynx nourishing and clearing pharynx granules can also be used for nasal fumigation therapy.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] The Yangyan Qingyan granules provided by the present invention are rigorously and cleverly formulated according to the theory of "monarch, minister, assistant and envoy" of traditional Chinese medicine. The raw rehmannia is the monarch, which is sweet, bitter and cold in nature and flavor, and can nourish kidney yin, moisten lung dryness, and clear deficiency fire; the Scrophularia nourishes yin and reduces fire, detoxifies and disperses knots, the Ophiopogon moistens the lungs and produces fluid, and the White Peony Root restrains yin and releases heat. The three medicines help the raw rehmannia nourish yin and moisten, and serve as the minister; the lily nourishes yin, moistens the lungs and relieves cough, the peony bark clears heat and cools blood, activates blood circulation and relieves swelling, and the Fritillaria thunbergii clears heat and disperses knots, resolves phlegm and relieves cough. From the perspective of modern pharmacology, it has the pharmacological effects of anti-inflammatory, improving microcirculation and immunomodulation, thereby treating chronic pharyngitis, shortening the treatment time, and reducing the frequency of repeated attacks. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 A preparation flow chart of Yangyan Qingyan granules; DETAILED DESCRIPTION

[0019] The present invention is further described in detail below in conjunction with the accompanying drawings and embodiments:

[0020] A throat nourishing and clearing granule, which is composed of raw rehmannia root, ophiopogon japonicus, white peony root, peony bark, thunbergii bulb, Scrophularia ningpoensis, and lily. The raw rehmannia root is the main ingredient, and Scrophularia ningpoensis, ophiopogon japonicus, and white peony root are the auxiliary ingredients, which can help nourish yin and moisten the lungs; at the same time, peony bark, thunbergii bulb, and lily are used as auxiliary ingredients; the whole formula has the effects of nourishing yin and moistening the lungs, clearing away heat and relieving throat pain, and reducing swelling and dispersing nodules, thereby alleviating pharyngitis and enhancing immune function. It is mainly suitable for symptoms such as dry mouth and throat, dry cough with little sputum, itchy throat, and foreign body sensation in the throat caused by yin deficiency and lung heat, and patients with chronic pharyngitis with the above symptoms;

[0021] like Figure 1 As shown, a throat nourishing and throat clearing granule and a preparation method thereof, comprising the following components by weight: 10-20 parts of raw rehmannia root, 10-20 parts of ophiopogon japonicus, 10-20 parts of white peony root, 5-15 parts of peony bark, 5-15 parts of thunbergii bulb, 10-20 parts of scrophularia ningpoensis, and 5-15 parts of lily;

[0022] The preparation method comprises:

[0023] S1. Raw material preparation: Take Radix Rehmanniae, Radix Ophiopogonis, White Peony Root, Cortex Moutan, Fritillaria Thunbergii, Scrophulariae, and Lilium respectively, weigh them, clean them and remove impurities for subsequent processing;

[0024] S2. Crushing: Grind the medicinal materials into fine and uniform powder;

[0025] S3, mixing: mixing different medicinal materials in a fixed proportion to ensure that the ingredients of the medicinal materials are evenly distributed;

[0026] S4, granulation: add appropriate amount of auxiliary materials and appropriate amount of water to the mixed medicinal materials, spray the mixture with water, and stir until it forms a mass;

[0027] S5, drying: drying the obtained particles, and using vacuum drying to reduce the moisture content of the particles;

[0028] S6. Screening: Screen the dried particles to remove unqualified particles, screen out the required particle size, make the particle size uniform, and obtain the prepared particles.

[0029] The pharmacological effects of each ingredient are as follows:

[0030] Shengdihuang: clears heat and cools blood, nourishes yin and produces body fluid. Indications: heat entering the blood, fever toxicity causing rash, febrile disease damaging yin, red tongue and thirst, body fluid damage and constipation, yin deficiency fever, internal heat and thirst.

[0031] Ophiopogon japonicus: nourishes yin and moistens the lungs, clears the heart and relieves restlessness, benefits the stomach and produces body fluid. It is mainly used to treat dry cough due to lung dryness, vomiting blood, hemoptysis, lung tuberculosis, lung abscess, fatigue, irritability, thirst, damage to body fluid due to fever, dry throat and mouth, and constipation.

[0032] White peony root: astringes yin and stops sweating, nourishes blood and softens liver, relieves pain. It is mainly used to treat spontaneous sweating, night sweats, fever due to yin deficiency, pain in the ribs, diarrhea, abdominal pain, irregular menstruation, metrorrhagia, and leucorrhea.

[0033] Peony bark: clears heat and cools blood, activates blood circulation and removes blood stasis. Used for heat entering the blood, fever and toxicity causing spots, carbuncle, sore, night heat and morning coolness, and bone steaming without sweat.

[0034] Fritillaria thunbergii: clears away heat and resolves phlegm, dissipates stagnation and detoxifies. It is mainly used to treat wind-heat cough, lung abscess, throat paralysis, scrofula, sores and swelling.

[0035] Scrophularia: clears heat and cools blood, nourishes yin and reduces fire, detoxifies and disperses stagnation. It is mainly used to treat heat entering the blood, fever toxicity causing spots, febrile disease damaging yin, red tongue and thirst, fluid damage and constipation, bone steaming and fatigue cough, sore throat, diphtheria, scrofula, carbuncle, swelling and sore.

[0036] Lily: nourishes yin and moistens the lungs, relieves cough, clears the heart and calms the mind. It is mainly used to treat chronic cough caused by lung dryness or yin deficiency, coughing up blood in sputum, residual heat after fever, and restlessness and palpitations.

[0037] The specific implementation process is as follows:

[0038] Example 1: Zhou, male, 11 years old

[0039] Initial visit (July 11, 2020): complained of foreign body sensation in the throat accompanied by throat clearing for 3 weeks; the child complained of foreign body sensation in the throat without obvious cause 3 weeks ago, frequent throat clearing, no cough or sputum, aggravated by excessive use of the throat or eating, no dry throat, sore throat, itchy throat, no nasal congestion, runny nose, fever and chills; the child was in general spirit, had a good diet, poor sleep at night, night sweats, normal urination, and slightly dry stools 2-3 days / time; specialist examination showed chronic congestion of the pharyngeal mucosa and obvious hyperplasia of lymphoid follicles on the posterior pharyngeal wall. The tongue was red, with a light yellow and less fur, and a thin and slightly rapid pulse.

[0040] Syndrome differentiation and analysis: The child has throat discomfort, which is classified as chronic pharyngitis; night sweats and dry stools, plus the child's tongue is not dry and thin, with sufficient saliva on the tongue surface, and no obvious growth retardation and other symptoms, indicating Yin deficiency but no damage to kidney Yin, the syndrome is Yin deficiency and lung heat; the tongue is red, the tongue coating is light yellow and less, and the pulse is thin and slightly rapid, which is also a sign of Yin deficiency.

[0041] Diagnosis: Chronic laryngitis (chronic pharyngitis)

[0042] Syndrome differentiation: Yin deficiency and lung heat syndrome.

[0043] Treatment: Nourish yin and clear the lungs, moisten the throat and relieve pharyngitis

[0044] Prescription: 15g of Radix Rehmanniae, 15g of Radix Ophiopogonis, 15g of Radix Paeoniae Alba, 10g of Cortex Moutan, 10g of Fritillariae Thunbergii, 15g of Radix Scrophulariae, 10g of Lilium. 9 doses, taken with water, once in the morning and once in the evening. Instruct the patient to take it with 200-250ml of hot water, and inhale the steam through the mouth and nose for 10-15 minutes while the liquid is emitting steam, and take it when the liquid is warm.

[0045] Second visit (September 5, 2020): The child reported that the foreign body sensation in the throat improved after the first dose of the medicine, and the parents reported that the child still often cleared his throat. The child was in good spirits, had good appetite and sleep, and night sweats were significantly improved compared with before. Urinating was normal, and the stool was 1-2 times / day, slightly sticky. Physical examination: Chronic congestion of the pharyngeal mucosa, hyperplasia of lymphoid follicles on the posterior pharyngeal wall. The tongue was red, the coating was slightly yellow, and the pulse was thin and slightly rapid. The original prescription was modified according to the symptoms, and another 9 doses were taken.

[0046] Third visit: (December 19, 2020) After taking the above prescription, the parents reported that the foreign body sensation in the throat had improved, there were no more night sweats, and the bowel movements were 2 to 3 times a day, but not dry and hard.

[0047] Example 2: Wang, female, 55 years old

[0048] Initial visit (May 29, 2024): complained of repeated throat itching and coughing for half a month; the patient reported that there was no obvious cause for throat itching and coughing half a month ago, dry cough with little sputum, sticky sputum and difficult to cough; especially at night, often aggravated after excessive use of the throat, accompanied by dry throat, no obvious throat pain, no nasal congestion and runny nose; poor sleep at night, normal appetite, normal bowel movements; specialist examination showed no congestion in the pharynx, large tonsils, and obvious hyperplasia of lymph follicles on the posterior pharyngeal wall. The tongue is red, the coating is yellow and greasy, and the pulse is thin and rapid.

[0049] Syndrome differentiation analysis: The patient had an itchy throat and cough, which was diagnosed as chronic pharyngitis; the patient had a dry and itchy throat, a dry cough with little sputum, and it was aggravated at night, indicating that the body fluid was deficient and could not moisten the throat, the lung yin was insufficient, and the internal heat burned the lungs, resulting in the lungs losing their ability to clear and purify, and the qi went against the flow and caused cough. Combined with the tongue and pulse, the syndrome was yin deficiency and lung heat.

[0050] Diagnosis: Chronic laryngitis (chronic pharyngitis)

[0051] Syndrome differentiation: Yin deficiency and lung heat syndrome.

[0052] Treatment: Nourishes yin and lungs, relieves cough and sore throat

[0053] Prescription: 15g of Radix Rehmanniae, 15g of Radix Ophiopogonis, 15g of Radix Paeoniae Alba, 10g of Cortex Moutan, 10g of Fritillariae Thunbergii, 15g of Radix Scrophulariae, 10g of Lilium. 9 doses, decocted and taken warm, 1 dose per day. Instruct the patient to take it with 200-250ml of hot water, and inhale the steam through the mouth and nose for 10-15 minutes while the liquid is emitting steam, and take it when the liquid is warm.

[0054] Second visit (June 12, 2024): The patient reported that the symptoms were significantly relieved after taking the previous prescription. There is no cough, sputum, dry throat and tongue. There is a slight itchy throat, normal sleep at night, good appetite, and normal bowel movements. The tongue is red, the coating is yellow, and the pulse is thin. The original prescription was given again. Follow-up in July showed that the patient's symptoms did not recur.

[0055] Example 3: Clinical trial of a throat-nourishing and throat-clearing granule

[0056] 1. Subject selection criteria:

[0057] 1) Meet the diagnosis criteria of chronic pharyngitis in both traditional Chinese and Western medicine and the syndrome differentiation criteria of Yin deficiency and lung heat;

[0058] 2) The patient is informed and signs the consent form;

[0059] 3) Aged ≥ 18 years;

[0060] 4) No anti-inflammatory drugs were taken within 3 months before enrollment;

[0061] 5) No drug contraindications;

[0062] 2. Test samples, sample use method and time

[0063] Test Group:

[0064] Test sample: Yangyan Qingyan granules

[0065] Directions for use: Take one bag of the test sample each time and mix it with 200-250ml of hot water. Inhale the steam through the mouth and nose for 10-15 minutes before taking the medicine, and then take it when the Chinese medicine is warm.

[0066] Duration of use: two weeks, once in the morning and once in the evening.

[0067] Control group:

[0068] Test sample: Xuanmai Ganju Granules (National Medicine Standard Z53021631)

[0069] Directions: Take with water.

[0070] Duration of use: two weeks, 10g each time, three times a day.

[0071] Test treatment

[0072] The trial period is 2 weeks.

[0073] Clinical efficacy evaluation criteria

[0074] Cured: symptoms and signs completely disappear; markedly effective: symptoms and signs significantly improved; effective: symptoms and signs improved; ineffective: symptoms and signs remained unchanged or aggravated. Total effective rate (%) = (number of cured cases + number of markedly effective cases + number of effective cases) / total number of cases × 100%.

[0075] V. Analysis of trial results

[0076] As shown in Table 1, 60 patients with chronic pharyngitis due to Yin deficiency and lung heat were included as research subjects and randomly divided into a test group (Yangyan Qingyan granules) and a control group (using Xuanmai Ganju granules), 30 people in each group, and the intervention lasted for 14 days. Among the 30 patients in the test group, 6 were in the clinically effective range, 22 were in the effective range, 2 were ineffective, and the overall effective rate was 93.33%; among the 30 patients in the control group, 2 were in the clinically effective range, 22 were in the effective range, 6 were ineffective, and the overall effective rate was 80%. Comparison between the groups showed that the total effective rate (χ2 test) of the test group was better than that of the control group, and the differences were statistically significant (P<0.05).

[0077] Table 1: Comparison of efficacy between the two groups of patients Unit: Cases (%)

[0078]

[0079] The above is only an embodiment of the present invention, and the common knowledge such as the known specific technical solutions and / or characteristics in the solution is not described in detail here. It should be pointed out that for those skilled in the art, without departing from the technical solution of the present invention, several modifications and improvements can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A throat nourishing and clearing granule and a preparation method thereof, characterized in that: The following components are included by weight: 10-20 parts of Radix Rehmanniae, 10-20 parts of Radix Ophiopogonis, 10-20 parts of Radix Paeoniae Alba, 5-15 parts of Cortex Moutan, 5-15 parts of Fritillaria Thunbergii, 10-20 parts of Scrophulariae, and 5-15 parts of Lilium; The preparation method comprises: S1. Raw material preparation: Take Radix Rehmanniae, Radix Ophiopogonis, White Peony Root, Cortex Moutan, Fritillaria Thunbergii, Scrophulariae, and Lilium respectively, weigh them, clean them and remove impurities for subsequent processing; S2. Crushing: Grind the medicinal materials into fine and uniform powder; S3, mixing: mixing different medicinal materials in a fixed proportion to ensure that the ingredients of the medicinal materials are evenly distributed; S4, granulation: add appropriate amount of auxiliary materials and appropriate amount of water to the mixed medicinal materials, spray the mixture with water, and stir until it forms a mass; S5, drying: drying the obtained particles, and using vacuum drying to reduce the moisture content of the particles; S6. Screening: Screen the dried particles to remove unqualified particles, screen out the required particle size, make the particle size uniform, and obtain the prepared particles.

2. The use of the throat nourishing and clearing granules according to claim 1, characterized in that: The Yangyan Qingyan granules are used for treating throat discomforts such as sore throat, dry mouth and throat, itchy throat, etc. caused by yin deficiency and internal heat, and for treating chronic pharyngitis with the above symptoms.

3. The use of the throat nourishing and clearing granules according to claim 1, characterized in that: The throat nourishing and clearing granules can also be used in nasal fumigation therapy.

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