Sensitive skin repairing composition aiming at severe cold environment in winter and application of sensitive skin repairing composition

Abstract

The invention relates to the technical field of cosmetics, in particular to a sensitive skin repairing composition for a severe cold environment in winter and application of the sensitive skin repairing composition. The repairing composition comprises a camellia flower extract, camellia seed oil, camellia flower PDRN, galactoglucan and an European chestnut leaf extract, and the repairing composition effectively resists skin injury caused by a severe cold environment in winter by activating heat shock protein, inhibiting a cold receptor TRPM8, improving microcirculation and constructing a skin physical barrier. The skin-care lotion can effectively moisturize skin, relieve the problems of red skin, itching skin, scales, cracking skin and the like, has the effects of efficiently moisturizing, relieving and repairing skin, is mild and non-irritant, and is suitable for people with sensitive skin to use.

Description

Technical Field

[0001] This application relates to the field of cosmetic technology, and in particular to a sensitive skin repair composition for harsh winter environments and its application. Background Technology

[0002] The harsh cold and dry environment of winter poses a severe challenge to skin health. For example, low temperatures directly cause vasoconstriction in the skin, significantly reducing the secretion of sebaceous and sweat glands. This results in insufficient sebum synthesis to maintain a healthy skin barrier, weakening the skin's ability to retain moisture. Simultaneously, decreased ambient humidity accelerates the evaporation of moisture from the stratum corneum, leading to a decrease in its water content and increased transepidermal water loss, thus reducing skin elasticity. This damage to the skin barrier function caused by the combined effects of cold and dryness can further trigger an increase in inflammatory cytokines, manifesting as dry, tight, rough, and flaky skin, accompanied by significant itching. If the condition persists, it may exacerbate skin sensitivity and even induce skin problems such as asteatotic eczema, leading to symptoms like cracked skin and redness, severely impacting quality of life.

[0003] Currently, existing technologies for winter skin care primarily focus on basic moisturizing and external physical protection. Common skincare products often use humectants (such as glycerin and hyaluronic acid) to absorb moisture and occlusive agents (such as petrolatum and various plant oils) to form an oily protective film on the skin surface to reduce moisture loss. In addition, some products attempt to add ingredients such as ceramides to help repair the skin's lipid barrier. However, these methods have significant limitations: firstly, they are mostly passive protection, focusing on replenishing lost moisture and physically sealing it off, failing to actively enhance the skin cells' own ability to resist cold stress and maintain homeostasis at the molecular level; secondly, their mechanisms of action are often relatively singular, failing to systematically and synergistically intervene in the multiple pathophysiological aspects of skin damage caused by cold environments (such as low-temperature-triggered neurosensory abnormalities, microcirculatory disorders, and insufficient cellular stress protection mechanisms).

[0004] Therefore, developing a composition that can target multiple points and actively enhance the skin's cold resistance and repair capabilities is of great practical significance. Summary of the Invention

[0005] The purpose of this application is to overcome the shortcomings of the prior art and provide a sensitive skin repair composition and its application for use in cold winter environments.

[0006] To achieve the above objectives, the technical solution adopted in this application is as follows: This application provides a repair composition for sensitive skin in harsh winter environments, the repair composition comprising the following components in parts by weight: Camellia flower extract 0.5-7 parts, camellia seed oil 1-15 parts, camellia PDRN 0.01-1 part, galactoglucan 0.005-0.4 parts and European chestnut leaf extract 0.01-2 parts.

[0007] This application provides a sensitive skin repair composition for the harsh winter environment, comprising camellia flower extract, camellia seed oil, camellia PDRN, galactoglucan, and European chestnut leaf extract. This repair composition effectively resists skin damage caused by the harsh winter environment by activating heat shock proteins, inhibiting the cold receptor TRPM8, improving microcirculation, and building a physical barrier for the skin. It relieves problems such as redness, itching, scaling, and cracking of the skin, and has the effects of highly moisturizing, soothing, and repairing. It is also gentle and non-irritating, making it suitable for people with sensitive skin.

[0008] The repair composition includes camellia flower extract, camellia seed oil, and camellia PDRN. Camellia flower extract, derived from camellias that bloom in the cold winter, is from a plant renowned for its cold resistance. Through long-term adaptation to low temperatures, it has evolved unique physiological mechanisms, resulting in a high content of polyphenols and flavonoids, possessing strong antioxidant capabilities. This allows the extract to enhance the stress tolerance of skin cells under severe cold conditions, contributing to the overall cold-resistance of the composition. Camellia seed oil, a natural oil extracted from camellia seeds, is enriched with oleic acid and other unsaturated fatty acids to maintain cell membrane fluidity, adapting to the cold winter environment. This component highly integrates with the human sebum membrane, quickly building a robust biomimetic skin barrier, effectively preventing excessive moisture loss caused by the cold, and achieving deep moisturization and barrier repair. Camellia PDRN is a small molecule polydeoxyribonucleotide derived from camellia. Camellia's ability to maintain the stability of genetic material and cell vitality under low temperature conditions allows its PDRN to provide nucleotide raw materials for cell repair, regulate the skin's immune microenvironment, improve microcirculation, and promote tissue regeneration, thus ensuring the skin's energy supply and healthy homeostasis at low temperatures.

[0009] Furthermore, galactoglucan and European chestnut leaf extract are added to the repair composition. Galactoglucan is a biopolysaccharide polymerized from glucose and galactose, derived from the protective polysaccharide synthesized extracellularly by *Bacillus subtilis* from the permafrost of the high-altitude region. Through its excellent hygroscopic properties and the formation of a breathable protective film on the skin surface, it synergistically moisturizes and repairs the skin barrier (physical barrier), helping the skin resist dry environments. Additionally, the lipid membranes of galactoglucan and camellia seed oil can form a "water-oil dual-film" structure, achieving water-locking and moisturizing effects, jointly resisting dry environments and enhancing the integrity of the skin barrier. The added European chestnut leaf extract is derived from the long-lived and cold-resistant European chestnut tree (… Castanea sativa The leaves of this tree species exhibit resilience in cold climates, allowing the active ingredients in its extracts to precisely soothe skin discomfort and inflammation exacerbated by cold stimulation, thus helping to maintain skin health.

[0010] In this repair composition, camellia extract, camellia seed oil, and camellia PDRN work synergistically to simulate and enhance the skin cells' adaptation mechanisms in cold conditions from different dimensions. The three components are homologous, resulting in inherent complementarity and synergistic effects. Together, they improve the skin's cold resistance in terms of cell membrane fluidity, antioxidant defense, and energy homeostasis, thus better protecting the skin from damage caused by the harsh winter environment. This allows the composition to better achieve moisturizing, soothing, and repairing effects, making it suitable for people with sensitive skin.

[0011] In a preferred embodiment of the repair composition described in this application, the repair composition comprises the following components in parts by weight: 1-5 parts camellia flower extract, 3-10 parts camellia seed oil, 0.05-0.5 parts camellia flower PDRN, 0.01-0.2 parts galactoglucan and 0.1-1 parts European chestnut leaf extract.

[0012] Preferably, the repair composition comprises the following components in parts by weight: Camellia flower extract 2-3 parts, camellia seed oil 5-7 parts, camellia PDRN 0.1-0.2 parts, galactoglucan 0.05-0.1 parts and European chestnut leaf extract 0.4-0.6 parts.

[0013] The repair composition of this application preferably contains components within the above-mentioned weight range, which can more significantly affect the overall performance of the repair composition. When the weight of the components is further selected within the above-mentioned preferred and more preferred ranges, the overall effect of the repair composition is even better.

[0014] In a preferred embodiment of the repair composition described in this application, the total mass of the camellia extract and camellia PDRN accounts for 10-30% of the mass percentage of the repair composition.

[0015] Experimental studies have shown that by further balancing the mass ratio of the components in the repair composition, and selecting a combined mass percentage of camellia extract and camellia PDRN of 10-30% in the repair composition, the resulting repair composition can better enhance the skin's resistance to damage caused by the harsh winter environment. This allows the repair composition to better achieve its moisturizing, soothing, and repairing effects, resulting in a superior overall effect.

[0016] For example, the percentage of the sum of the masses of the camellia extract and camellia PDRN, based on the total mass of the repair composition, can be any point value or any two points between 10% and 30%, such as 10%, 11%, 15%, 20%, 25%, 27.8%, 29.3%, 30%, etc.

[0017] In a preferred embodiment of the repair composition described in this application, the molecular weight of the galactoglucan is 100-5000 kDa, preferably 1200 kDa.

[0018] The repair composition of this application uses galactoglucan within the above molecular weight range. The lipid membrane of galactoglucan and camellia seed oil can also form a "water-oil double membrane" structure to achieve the effects of water locking and moisturizing, jointly resisting dry environment, enhancing the integrity of the barrier, improving the physical cold resistance of the repair composition, and increasing the transdermal absorption of other active ingredients such as camellia extract and camellia PDRN.

[0019] If the molecular weight of galactoglucan is too small, it cannot form a film and will be difficult to form a protective film on the skin surface, thereby weakening the physical cold-resistant ability of the composition; if the molecular weight of galactoglucan is too large, it will result in a sticky and heavy feel on the skin, and may even cause pilling, and will also hinder the transdermal absorption of other active ingredients (such as camellia extract and camellia PDRN).

[0020] As a preferred embodiment of the repair composition described in this application, the method for preparing the camellia PDRN includes the following steps: S1. Take camellia flowers, dry them, grind them into powder, and sieve them to obtain camellia powder; S2. Add the camellia powder from step S1 to a buffer solution containing polyvinylpyrrolidone for ultrasonic extraction, centrifuge, and collect the supernatant. S3. Add anhydrous ethanol to the supernatant in step S2 to precipitate, collect the precipitate, wash, centrifuge, take the precipitate, and dry to obtain camellia PDRN.

[0021] Experimental studies have revealed that different extraction methods for camellia extract may result in variations in the effective active ingredients and their content, thus affecting the interaction between camellia PDRN and other components. This application describes ultrasonic extraction of camellia powder in a buffer solution containing polyvinylpyrrolidone, which can better extract the active ingredient camellia PDRN. When added to the repair composition, the resulting repair composition can better improve microcirculation and promote tissue regeneration, ensure the skin's energy supply and healthy homeostasis at low temperatures, and enhance the moisturizing, soothing, and repairing effects of the repair composition.

[0022] In the preparation method, polyvinylpyrrolidone (PVP) is added to eliminate polyphenol oxidation interference. Since camellia is rich in flavonoids and polyphenols, it is suitable to add PVP to protect DNA. Adding polyvinylpyrrolidone (PVP) can improve PDRN yield and reduce skin barrier damage.

[0023] In a preferred embodiment of the repair composition described in this application, in step S2, the buffer solution comprises Tris-HCl buffer; the mass concentration of polyvinylpyrrolidone in the buffer solution is 1~3 g / mL. The pH of the Tris-HCl buffer solution is 7.0~8.0.

[0024] As a preferred embodiment of the repair composition described in this application, the ratio of camellia powder to buffer solution is 1 g: (10~30) mL.

[0025] This application uses a polyvinylpyrrolidone buffer solution within the above-mentioned mass concentration range and the above-mentioned material-liquid ratio, which can better eliminate polyphenol oxidation interference, thereby improving the extraction of the active ingredient camellia PDRN, thus improving the overall performance of the repair composition, while avoiding reagent waste and reducing extraction costs.

[0026] In a preferred embodiment of the repair composition described in this application, in step S2, the ultrasonic extraction power is 400~600W, the ultrasonic extraction temperature is 25~50℃, and the ultrasonic extraction time is 30~60min.

[0027] The use of the aforementioned ultrasound conditions in this application allows for better extraction of the active ingredient camellia PDRN, improving microcirculation and promoting tissue regeneration, while ensuring the skin's energy supply and healthy homeostasis at low temperatures.

[0028] Preferably, in step S3, the volume ratio of the supernatant to anhydrous ethanol is 1:(2~4), more preferably 1:3.

[0029] Preferably, in step S1, the camellia powder is obtained by grinding and pulverizing the material through a 60-100 mesh sieve (preferably a 60-100 mesh sieve, preferably 80 mesh).

[0030] This application also provides a method for preparing the above-mentioned repair composition, comprising the following steps: Camellia flower extract, camellia seed oil, camellia PDRN, galactoglucan, and European chestnut leaf extract were mixed to obtain a repairing composition.

[0031] This application also provides the use of the above-described repair composition in the preparation of cosmetics.

[0032] Preferably, the cosmetic is suitable for sensitive skin.

[0033] The cosmetics include any one of toner, lotion, cream, mask, or spray.

[0034] The cosmetic product includes the aforementioned repair composition and also contains excipients acceptable in the cosmetic field.

[0035] This application also provides a cosmetic product, which includes a face cream, the face cream comprising the following components in weight percentages: Thickener 0.05-0.5%, humectant 0.5-3%, pH adjuster 0.01-0.3%, oil phase 3-15%, preservative 0.5-2%, the repair composition 5-15%, and deionized water as the balance.

[0036] Preferably, the thickener comprises at least one of the following: polyacrylate crosspolymer-6, carbomer, carrageenan, gellan gum, xanthan gum, microcrystalline cellulose, cellulose gum, ethyl cellulose, sclerotium taurate gum, guar gum, ammonium acryloyl dimethyl taurate / VP copolymer, acrylate copolymers, and sclerotium taurate gum.

[0037] And / or, the moisturizer includes at least one of glycerin, 1,2-butanediol, 1,3-butanediol, 1,2-hexanediol, 1,3-propanediol, caprylyl glycol, dipropylene glycol, tremella polysaccharide, trehalose, betaine, allantoin, sodium hyaluronate, β-glucan, budding stalk polysaccharide, and ceramide. And / or, the pH adjuster includes arginine and / or tromethamine; And / or, the oil phase comprises at least one of the following: caprylic / capric triglyceride, C14-22 alcohol, C12-20 alkyl glucoside, sodium polyacrylate, hydrogenated lecithin, cetearyl glucoside, isononyl isononanoate, pentaerythritol tetraester, stearyl alcohol, hydroxystearic acid, polymethylsilsesquioxane, pentaerythritol distearate, and sucrose stearate; And / or, the preservative includes 1,2-hexanediol and / or p-hydroxyacetophenone.

[0038] Compared with the prior art, this application has the following beneficial effects: This application provides a sensitive skin repair composition and its application for use in cold winter environments. The repair composition includes camellia flower extract, camellia seed oil, camellia PDRN, galactoglucan, and European chestnut leaf extract. This repair composition effectively resists skin damage caused by cold winter environments by activating heat shock proteins, inhibiting the cold receptor TRPM8, improving microcirculation, and building a physical barrier for the skin. It relieves problems such as redness, itching, scaling, and cracking of the skin, and has highly effective moisturizing, soothing, and repairing effects. It is also gentle and non-irritating, making it suitable for people with sensitive skin. Attached Figure Description

[0039] Figure 1 This is a comparison image of the facial red area between Example 6 in Experiment 4 and the blank application example. Detailed Implementation

[0040] To better illustrate the purpose, technical solution, and advantages of this application, the following description will be provided in conjunction with the accompanying drawings and specific embodiments.

[0041] Unless otherwise specified, the experimental methods used in the following examples and comparative examples are conventional methods, and the materials and reagents used are commercially available unless otherwise specified.

[0042] In the following embodiments and comparative examples: Camellia extract: Trade name RedSnow®, purchased from Clariant, Switzerland; Camellia seed oil: Camellia (CAMELLIA JAPONICA) seed oil extracted by physical cold pressing, purchased from Shenzhen Dingcheng Plant Fragrance Co., Ltd. Galactoglucan-1: Trade name Furuike® M120, molecular weight 1200 kDa, purchased from Chengdu Saidike Biotechnology Co., Ltd.; Galactoglucan-2: Trade name Furuike® H500, molecular weight 5000 kDa, purchased from Chengdu Saidike Biotechnology Co., Ltd.; Galactoglucan-3: Trade name Furuike® L-10, molecular weight 100 kDa, purchased from Chengdu Saidike Biotechnology Co., Ltd.; European chestnut leaf extract: trade name CASTALINE, purchased from BASF, Germany; Rose extract: Product code BDSW-0405-142, purchased from Bodi Biotechnology (Shanxi) Co., Ltd. Green tea seed oil: purchased from Ji'an Guoguang Fragrance Factory; Salmon PDRN: Trade name PDRN-C, purchased from Shanghai Saimengxin Biotechnology Co., Ltd.; Oat β-glucan: molecular weight 300 kDa, purchased from Zhongshan Kexin Biotechnology Co., Ltd.; Platycladus orientalis leaf extract: Product code JH-CBY, purchased from Shaanxi Junhe Biotechnology Co., Ltd.

[0043] Among them, camellia PDRN includes camellia PDRN 1~6; Camellia PDRN1 Homemade, the preparation method includes the following steps: S1. Take camellia flowers, dry them, grind them into powder and pass them through an 80-mesh sieve to obtain camellia powder; S2. The camellia powder from step S1 was added to a Tris-HCl buffer solution (pH=8.0) containing 2% (w / v) polyvinylpyrrolidone for ultrasonic extraction. The ratio of camellia powder to buffer solution was 1 g: 20 mL. The ultrasonic extraction power was 500 W, the ultrasonic extraction temperature was 40 °C, and the ultrasonic extraction time was 40 min. After centrifugation, the supernatant was collected. S3. Add 3 times the volume of anhydrous ethanol to the supernatant in step S2 to precipitate the DNA. Collect the precipitate and wash it with anhydrous ethanol to remove impurities. Centrifuge the precipitate and dry it to obtain camellia PDRN 1.

[0044] Camellia PDRN 2 Homemade, the preparation method includes the following steps: S1. Take the camellia flowers, dry them, grind them into powder and pass them through a 60-mesh sieve to obtain camellia powder; S2. The camellia powder from step S1 was added to a Tris-HCl buffer (pH=8.0) containing 1% (w / v) polyvinylpyrrolidone for ultrasonic extraction. The ratio of camellia powder to buffer was 1 g: 10 mL. The ultrasonic extraction power was 400 W, the ultrasonic extraction temperature was 25 °C, and the ultrasonic extraction time was 30 min. After centrifugation, the supernatant was collected. S3. Add 3 times the volume of anhydrous ethanol to the supernatant in step S2 to precipitate the DNA. Collect the precipitate and wash it with anhydrous ethanol to remove impurities. Centrifuge to collect the precipitate and dry it to obtain camellia PDRN 2.

[0045] Camellia PDRN 3 Homemade, the preparation method includes the following steps: S1. Take camellia flowers, dry them, grind them into powder and pass them through a 100-mesh sieve to obtain camellia powder; S2. The camellia powder from step S1 was added to a Tris-HCl buffer (pH=8.0) containing 3% (w / v) polyvinylpyrrolidone for ultrasonic extraction. The ratio of camellia powder to buffer was 1 g: 30 mL. The ultrasonic extraction power was 600 W, the ultrasonic extraction temperature was 50 °C, and the ultrasonic extraction time was 60 min. After centrifugation, the supernatant was collected. S3. Add 3 times the volume of anhydrous ethanol to the supernatant in step S2 to precipitate the DNA. Collect the precipitate and wash it with anhydrous ethanol to remove impurities. Centrifuge to collect the precipitate and dry it to obtain camellia PDRN 3.

[0046] Camellia PDRN 4 Homemade, the preparation method includes the following steps: S1. Take camellia flowers, dry them, grind them into powder and pass them through an 80-mesh sieve to obtain camellia powder; S2. The camellia powder from step S1 was added to a Tris-HCl buffer (pH=8.0) containing 8% (w / v) polyvinylpyrrolidone for ultrasonic extraction. The ratio of camellia powder to buffer was 1 g: 20 mL. The ultrasonic extraction power was 500 W, the ultrasonic extraction temperature was 40 °C, and the ultrasonic extraction time was 40 min. After centrifugation, the supernatant was collected. S3. Add 3 times the volume of anhydrous ethanol to the supernatant in step S2 to precipitate the DNA. Collect the precipitate and wash it with anhydrous ethanol to remove impurities. Centrifuge to collect the precipitate and dry it to obtain camellia PDRN 4.

[0047] Camellia PDRN 5 Homemade, the preparation method includes the following steps: S1. Take camellia flowers, dry them, grind them into powder and pass them through an 80-mesh sieve to obtain camellia powder; S2. The camellia powder from step S1 was added to a Tris-HCl buffer solution (pH=8.0) containing 2% (w / v) polyvinylpyrrolidone for ultrasonic extraction. The ratio of camellia powder to buffer solution was 1 g: 20 mL. The ultrasonic extraction power was 800 W, the ultrasonic extraction temperature was 60 °C, and the ultrasonic extraction time was 60 min. After centrifugation, the supernatant was collected. S3. Add 3 times the volume of anhydrous ethanol to the supernatant in step S2 to precipitate the DNA. Collect the precipitate and wash it with anhydrous ethanol to remove impurities. Centrifuge to collect the precipitate and dry it to obtain camellia PDRN 5.

[0048] Camellia PDRN 6 Homemade, the preparation method includes the following steps: S1. Take camellia flowers, dry them, grind them into powder and pass them through an 80-mesh sieve to obtain camellia powder; S2. Add the camellia powder from step S1 to pure water and boil to extract. The ratio of camellia powder to water is 1 g: 20 mL. The heating temperature is 105℃ and the heating time is 60 min. Centrifuge and take the supernatant. S3. Add 3 times the volume of anhydrous ethanol to the supernatant in step S2 to precipitate the DNA. Collect the precipitate and wash it with anhydrous ethanol to remove impurities. Centrifuge to collect the precipitate and dry it to obtain camellia PDRN 6.

[0049] Examples 1-6 and Comparative Examples 1-8 The embodiments and comparative examples of this application provide a sensitive skin repair composition for harsh winter environments, the components (parts by weight) of which are shown in Table 1.

[0050] Table 1 The method for preparing the repair composition provided in Example 1 of this application includes the following steps: Camellia flower extract, camellia seed oil, camellia PDRN 1, galactoglucan-1 and European chestnut leaf extract were mixed to obtain a repairing composition.

[0051] The preparation methods of the repair compositions provided in Examples 2-6 and Comparative Examples 1-8 are consistent with those in Example 1.

[0052] If the comparative formulation does not contain any of the following ingredients: camellia flower extract, camellia seed oil, camellia PDRN 1, galactoglucan-1, and European chestnut leaf extract, then the preparation method does not include them.

[0053] Example 7 This embodiment provides a repair composition, which differs from that of Example 6 in that camellia PDRN2 is used instead of camellia PDRN1, and the preparation method is the same as that of Example 6.

[0054] Example 8 This embodiment provides a repair composition, which differs from that of Example 6 in that camellia PDRN 3 is used instead of camellia PDRN 1, and the preparation method is the same as that of Example 6.

[0055] Example 9 This embodiment provides a repair composition, which differs from that of Example 6 in that camellia PDRN 4 is used instead of camellia PDRN 1, and the preparation method is the same as that of Example 6.

[0056] Example 10 This embodiment provides a repair composition, which differs from that of Example 6 in that camellia PDRN 5 is used instead of camellia PDRN 1, and the preparation method is the same as that of Example 6.

[0057] Example 11 This embodiment provides a repair composition, which differs from that of Example 6 in that galactoglucan-1 is replaced with galactoglucan-2, and the preparation method is the same as that of Example 6.

[0058] Example 12 This embodiment provides a repair composition that differs from that of Example 6 in that galactoglucan-1 is replaced with galactoglucan-3, and the preparation method is the same as that of Example 6.

[0059] Comparative Example 9 This comparative example provides a repair composition that differs from Example 6 in that rose extract is used instead of camellia extract, and the preparation method is the same as in Example 6.

[0060] Comparative Example 10 This comparative example provides a repair composition that differs from Example 6 in that green tea seed oil is used instead of camellia seed oil, and the preparation method is the same as in Example 6.

[0061] Comparative Example 11 This comparative example provides a repair composition that differs from Example 6 in that it uses camellia PDRN 6 instead of camellia PDRN 1, and the preparation method is the same as in Example 6.

[0062] Comparative Example 12 This comparative example provides a repair composition that differs from Example 6 in that salmon PDRN is used instead of camellia PDRN 1, and the preparation method is the same as in Example 6.

[0063] Comparative Example 13 This comparative example provides a repair composition that differs from Example 6 in that oat β-glucan is used instead of galactoglucan-1, and the preparation method is the same as in Example 6.

[0064] Comparative Example 14 This comparative example provides a repair composition that differs from Example 6 in that it uses Platycladus orientalis leaf extract instead of Chestnut leaf extract, and is prepared using the same method as Example 6.

[0065] Application Examples 1-14, Comparison of Application Examples 1-14 and Blank Application Example This application provides a face cream in application examples, comparative application examples, and blank application examples. The components (mass percentage) of the face cream are shown in Table 2. Among them, the repair compositions used in application examples 1 to 12 are the repair compositions prepared in examples 1 to 12, respectively. The repair compositions used in comparative application examples 1 to 14 are the repair compositions prepared in comparative examples 1 to 14, respectively. The repair compositions used in application examples 13 to 14 are the repair compositions prepared in example 6.

[0066] Table 2 The method for preparing the face cream provided in Example 1 includes the following steps: (1) Mix the humectant and thickener with water and stir. Heat to 85±2℃ and homogenize at 1200 rpm for 4 min. After homogenization, keep warm for later use to obtain pre-prepared component A. (2) Mix the oil phase components, heat to 85±2℃, homogenize at 1200 rpm for 4 min, keep warm after homogenization, and obtain pre-prepared component B; (3) Mix the preservatives and heat to 60±2℃ to melt them, to obtain the pre-prepared component C; (4) Heat the pre-prepared component A to 80±2℃, add the pre-prepared component B at 250 rpm and stir to mix. Then cool down to 60±2℃ and add the pre-prepared component C at 250 rpm and stir to mix. Then cool down to 40℃ and add the repair composition and continue stirring for 8 min. Finally, add the remaining pH adjuster to adjust the pH to 6.0, then stop stirring, discharge the product, and obtain the face cream.

[0067] The preparation methods of the face creams provided in Application Examples 2-14, Comparative Application Examples 1-14, and Blank Application Examples are consistent with those in Application Example 1. If the relevant components are not available, they can be omitted.

[0068] Test Example 1: Test on the Cold Resistance of the Repairing Composition to the Skin This study investigates the effect of the repair compositions prepared in Examples 1-12 and Comparative Examples 1-14 on improving the skin's cold resistance.

[0069] Experimental materials: The cell line used was human keratinocytes (HaCaT, Beina Biotechnology). The testing conditions were: incubator temperature 37±1℃, humidity 90±5%, carbon dioxide 5±1%. Cells were cultured and treated according to groups, followed by testing. Specifically, the levels of heat shock proteins and TRPM8 were detected using the following methods: (1) Seed the cell suspension into a 96-well cell culture plate at a density of 2000 cells / well, add 100 μL of culture medium to each well, and after culturing for 24 hours, discard the supernatant; (2) 100 μL of DMEM medium (2105341, Gibco) was added to the blank control group, and 100 μL of DMEM medium containing 0.1% w / v corresponding repair composition (Examples 1-12 and Comparative Examples 1-14) was added to the sample group. The samples were cultured at 37°C for 2 h, and then transferred to 28°C for 5 h of further culture. (3) After the culture is completed, discard the culture medium, collect the cells, wash them 3 times with PBS buffer, add 50 μL of RIPA cell lysis buffer containing protease inhibitor to each well, centrifuge the lysed sample at 12000 g for 5 minutes, and take the supernatant. (4) Determination of heat shock protein content: Follow the instructions of the human heat shock protein 70 (HSP-70) ELISA kit (catalog number ml105347, Shanghai Enzyme-Linked Biotechnology). Take equal amounts of cell culture supernatant from the blank control group and the sample group, add them to the corresponding reaction wells of the kit, and after incubation, washing, and color development, measure the absorbance value at a specific wavelength using an ELISA reader. Calculate the content of heat shock protein in each group based on the standard curve. (5) TRPM8 content determination: The human conversion receptor potential cation channel subfamily M member 8 (TRPM8) ELISA kit (product number SPS-16279, Saipesen Biotechnology) was operated according to the instructions. Equal amounts of cell culture supernatant from the blank control group and the sample group were added to the corresponding reaction wells of the kit. After incubation, washing, color development and other steps, the absorbance value was measured at a specific wavelength using an ELISA reader. The TRPM8 content of each group was calculated according to the standard curve. Heat shock proteins (HSPs) are a group of molecular chaperone proteins that are synthesized and increased by cells under various stress conditions such as high temperature, low temperature, and oxidation. They help skin cells maintain homeostasis and enhance their ability to withstand harsh environments by repairing and clearing misfolded or damaged proteins caused by stress, inhibiting inflammatory pathways, and enhancing the cell's antioxidant defense capabilities. In cold environments, the activation of heat shock proteins (such as HSP70) can protect skin cells from cold-induced barrier function damage and moisture loss, enhancing the skin's overall resistance.

[0070] TRPM8 is a major cold receptor in the skin, widely expressed on sensory nerve endings, keratinocytes, and other skin cells. In cold environments, TRPM8 is activated and generates cold signals, triggering a series of physiological changes such as vasoconstriction and increased inflammation, thereby reducing skin tolerance. Inhibiting TRPM8 activity can help the skin cope more smoothly with low temperatures and improve its cold resistance.

[0071] Higher levels of heat shock proteins and lower levels of TRPM8 after sample treatment indicate a better effect of the composition in improving skin cold resistance. The effect of the repair composition in improving skin cold resistance is expressed by the increase rate of heat shock proteins and the inhibition rate of TRPM8, as shown in the following formula: The increase rate of heat shock proteins = (sample group / blank group - 1) * 100%; TRPM8 inhibition rate = (1 - sample group / blank group) * 100%; The test results are shown in Table 3.

[0072] Table 3 The results are shown in Table 3. Using the technical solution provided in this application, the repair composition obtained has the ability to activate heat shock proteins and inhibit the cold receptor TRPM8. Among them, the increase rate of heat shock proteins and the inhibition rate of TRPM8 in Examples 1 to 12 are relatively high.

[0073] As can be seen from Examples 1-6, the mass fraction of the components in the repair composition and the mass percentage of certain components (camellia extract and camellia PDRN) in the repair composition both affect the overall performance of the repair composition. When the mass fraction of the components is further selected within the range given in this application, the overall performance of the obtained repair composition is even better. The increase rate of heat shock protein is 31.5%~45.7%, and the inhibition rate of TRPM8 is 49.6%~68.3%.

[0074] Examples 6 and 7-10 demonstrate that the selection of parameters in the preparation method of camellia PDRN also affects the overall performance of the repair composition. The camellia PDRN preparation method described in this application allows for better extraction of the active ingredient, camellia PDRN, which, when added to the repair composition, significantly improves the increase rate of heat shock proteins and the inhibition rate of TRPM8. In contrast, Comparative Example 11, using a conventional DNA extraction method, resulted in a repair composition with lower increases in heat shock proteins and inhibition rates of TRPM8.

[0075] As can be seen from Examples 6 and 11-12, the increase rate of heat shock proteins and the inhibition rate of TRPM8 in the repair compositions of Examples 11-12 are slightly lower. The selection of parameters in the components also affects the overall performance of the repair composition. The repair composition of this application uses galactoglucan within the above-mentioned molecular weight range. Galactoglucan has excellent hygroscopicity and forms a breathable protective film on the skin surface, synergistically moisturizing and repairing the barrier, helping the skin resist dry environments, and can improve the physical cold resistance of the repair composition. At the same time, using galactoglucan within the above-mentioned molecular weight range can increase the transdermal absorption of other active ingredients such as camellia extract and camellia PDRN, thereby the prepared repair composition has a better cold resistance effect.

[0076] As can be seen from Examples 6 and Comparative Examples 1-8, the effects of this application cannot be achieved when one of the components is not added, or when a component is added to another component in parts by weight without adding the component. The repair composition of this application contains camellia extract, camellia seed oil, camellia PDRN, galactoglucan and European chestnut leaf extract in the above-mentioned weight range. The prepared repair composition effectively resists skin damage caused by the cold winter environment by activating heat shock proteins, inhibiting the cold receptor TRPM8, improving microcirculation and building a physical barrier for the skin. It relieves problems such as redness, itching, scaling and cracking of the skin, and has the effects of highly moisturizing, soothing and repairing. It is also gentle and non-irritating and suitable for people with sensitive skin. By comparing Example 6 and Comparative Examples 1-3, it can be seen that the camellia extract, camellia seed oil, and camellia PDRN in the repair composition work synergistically to simulate and enhance the skin cells' adaptation mechanism in cold from different dimensions. The three components are homologous, which makes them inherently complementary and synergistic. Together, they improve the skin's cold resistance from three aspects: cell membrane fluidity, antioxidant defense, and energy homeostasis. This can better enhance the skin's resistance to skin damage caused by the harsh winter environment, and make the composition better achieve moisturizing, soothing, and repairing effects, making it suitable for people with sensitive skin.

[0077] By comparing Example 6 with Comparative Examples 2 and 4, it can be seen that the lipid membranes of galactoglucan and camellia seed oil can also form a "water-oil double membrane" structure, achieving the effects of water locking and moisturizing, jointly resisting dry environments, enhancing the integrity of the barrier, and better improving the physical cold resistance of the repair composition.

[0078] As can be seen from Examples 6 and Comparative Examples 9-10 and 12-14, when other components are used to replace the components in the repair composition of this application, the effect of the obtained product also shows a certain downward trend. This indicates that specific components have a significant impact on the increase rate of heat shock proteins and the inhibition rate of TRPM8 in the repair composition. Using the components of this application, such as camellia extract, camellia seed oil, camellia PDRN, galactoglucan and European chestnut leaf extract, can effectively improve the increase rate of heat shock proteins and the inhibition rate of TRPM8 in the repair composition.

[0079] Experimental Example 2: The effect of the repair composition on promoting microcirculation This study investigates the effect of the repair compositions prepared in Examples 1-12 and Comparative Examples 1-14 on promoting microcirculation.

[0080] Experimental methods: (1) Zebrafish source: Wild-type AB strain zebrafish (Danio rerio) from the China National Zebrafish Resource Center were used for spawning tests. The broodstock were 6-12 months old and had good reproductive capacity. Lateral crosses were used to maintain genetic diversity during propagation. Purebred broodstock were replaced with a new batch after 5 generations. All broodstock showed no obvious signs of infection or disease and had not undergone drug treatment within the past 2 months. Before the spawning test, the broodstock underwent laboratory acclimatization culture for more than 14 days. (2) Zebrafish farming: The water temperature for farming is 26℃~28.5℃, the stocking density is 1~2 fish per liter of water, the daily light is fixed at 12h~16h, the fish are fed twice a day with brine shrimp larvae at intervals of more than 3 hours, and a good filtration system is maintained. (3) Zebrafish spawning: Male and female zebrafish were placed in the spawning tank at a ratio of 2:1. Mating, spawning, and fertilization were completed within about 30 minutes after the lights were turned on. The eggs were collected using an egg collection box covered with an inert net. After the eggs were removed from the egg collection box, the embryos were cleaned with fish embryo culture medium and cultured at 28℃±1℃ at a density of no more than one embryo per 200μL of fish embryo culture medium until 3 days after fertilization. (4) Test grouping: Healthy zebrafish embryos 3 days after fertilization were selected, and 24 embryos were randomly selected from each group and transferred to 6cm culture dishes. 8 mL of fish embryo culture medium was added to the blank control group, and 8 mL of fish embryo culture medium containing 0.1% w / v of the corresponding repair composition (Examples 1-12 and Comparative Examples 1-14) was added to the sample group. Each group was placed in a constant temperature incubator at 28±1℃ for 2±0.5h. (5) Microscopic analysis: Fish embryos were anesthetized with 0.04% w / v tricaine working solution for 2 min, and the dorsal aorta of the fish embryos was photographed under a microscope for 20 s.

[0081] (6) Data and Result Calculation: The relative velocity of blood flow in the dorsal aorta of each fish embryo was measured using the software DanioScope, and the average value was taken. The blood circulation promotion rate of the sample was calculated according to the following formula: Blood circulation promotion rate = (T − C) / C × 100%; Where: T—the average relative velocity of blood flow in the dorsal aorta of fish embryos in the sample group; C—the average relative velocity of blood flow in the dorsal aorta of fish embryos in the blank control group; The test results are shown in Table 4.

[0082] Table 4 The results are shown in Table 4. The repair composition obtained by using the technical solution provided in this application has a good effect on promoting microcirculation; the blood circulation promotion rate of the repair compositions in Examples 1 to 12 is 10.2% to 15.1%.

[0083] As can be seen from Examples 1 to 6, the mass fraction of the components in the repair composition and the mass percentage of some components (camellia extract, camellia PDRN) in the repair composition will affect the overall performance of the repair composition. When the mass fraction of the components is further selected within the range given in this application, the blood circulation promotion rate of the obtained repair composition is higher, which can better promote blood circulation and the overall performance of the repair composition is better.

[0084] Examples 6 and 7-10 demonstrate that the selection of parameters in the preparation method of camellia PDRN also affects the blood circulation effect of the repair composition. The camellia PDRN preparation method described in this application allows for better extraction of the active ingredient, camellia PDRN, which, when added to the repair composition, significantly improves the blood circulation promotion rate. In contrast, Comparative Example 11, using a conventional DNA extraction method, resulted in a repair composition with a poorer effect on improving the blood circulation promotion rate.

[0085] As can be seen from Examples 6 and 11-12, the blood circulation promotion rate of the repair compositions in Examples 11-12 is relatively low. The selection of parameters in the components also affects the function of the repair compositions in promoting blood circulation. The repair composition of this application uses galactoglucan in the above molecular weight range, combined with camellia extract, camellia seed oil and camellia PDRN and other components, which increases the transdermal absorption of other active ingredients such as camellia extract and camellia PDRN, so that the prepared repair composition has a better effect in promoting blood circulation.

[0086] As can be seen from Examples 6 and Comparative Examples 1-8, the effect of the repair composition in promoting blood circulation is poor when one of the components is not added, or when one component is added to another component without its addition. This indicates that the repair composition of this application contains camellia extract, camellia seed oil, camellia PDRN, galactoglucan, and European chestnut leaf extract in appropriate weight ranges. The repair composition effectively resists skin damage caused by the cold winter environment by activating heat shock proteins, inhibiting the cold receptor TRPM8, improving microcirculation, and building a physical barrier for the skin. It alleviates problems such as redness, itching, scaling, and cracking of the skin, and has the effects of highly effective moisturizing, soothing, and repairing. It is also gentle and non-irritating, making it suitable for people with sensitive skin. By comparing Example 6 and Comparative Examples 1-3, it can be seen that the camellia extract, camellia seed oil and camellia PDRN in the repair composition work synergistically to simulate and enhance the skin cells' adaptation mechanism in cold from different dimensions. The three components are homologous, which makes them inherently complementary and synergistic. Together, they improve the skin's cold resistance from three aspects: cell membrane fluidity, antioxidant defense and energy homeostasis. They can better promote blood circulation and improve the effect of resisting skin damage caused by the cold winter environment.

[0087] As can be seen from Examples 6 and Comparative Examples 9-10 and 12-14, when other components are used to replace the components in the repair composition of this application, the effect of the product also shows a certain downward trend. This indicates that using specific components such as camellia extract, camellia seed oil, camellia PDRN, galactoglucan and European chestnut leaf extract of this application can effectively improve the blood circulation promotion rate of the repair composition.

[0088] Experimental Example 3: Human Skin Patch Test Test method: Human patch test.

[0089] Testing Procedure: Sixty volunteers were recruited, 30 men and 30 women, aged 20-50 years, and randomly divided into two groups of 15 men and 15 women each. A closed patch test was used. Equal amounts (0.020 g-0.025 g) of the test samples (creams prepared for Application Examples 1-14, Control Application Examples 1-14, and the blank application example) were placed in a specific patch applicator. The applicator was then applied to the volunteer's arm with hypoallergenic adhesive tape, gently pressed to ensure even application, and left for 24 hours. The blank control group used distilled water, and the blank application example used a cream without the repair composition. One patch applicator was applied to each arm of each volunteer. Each patch applicator had 10 holes, allowing each volunteer (both arms) to test 20 samples simultaneously. The first group used the creams prepared for Application Examples 1-14 and the blank application example, while the second group used the creams prepared for Control Application Examples 1-14 and the blank application example. A blank control was included in each group. After 24 hours, the patch applicator was removed, and skin reactions were observed and recorded at 0.5 hours, 24 hours, and 48 hours. The severity of adverse skin reactions is shown in Table 5 below.

[0090] Table 5 After testing, the face creams prepared in Application Examples 1-14, Comparative Application Examples 1-14, and Blank Application Examples of this application all showed negative reactions after human patch testing, indicating that they are safe and non-irritating to human skin.

[0091] Experimental Example 4: Testing the Moisturizing, Soothing, and Repairing Efficacy of the Repairing Composition in Cold Environments Experimental Methods: During the winter season in Beijing (November to February of the following year), 174 Asian adult participants aged 18-60 who reported sensitive and dry skin were randomly divided into 29 groups of 6 participants each. Volunteers applied 1g of the sample to their entire face twice daily, morning and evening (the samples were face creams prepared from Application Examples 1-14, Control Application Examples 1-14, and the blank application example). Data were collected before use (T0) and after 28 days of use (T28). After arriving at the site, volunteers washed their faces with facial cleanser and sat quietly for 30 minutes in an air-conditioned room with a temperature of 21±1℃ and a humidity of 50±10%. Researchers then used a Corneometer probe to measure the skin moisture content of the cheekbones. The Visia-7 was used to photograph the volunteers' faces, and the exported red area images were analyzed to obtain the a* value. The transepidermal water loss (TEWL) value of the cheekbones was measured using a TewaMeter®™ Hex probe. A 10-point self-assessment questionnaire was used to evaluate the volunteers' skin itching (the higher the score, the stronger the itching).

[0092] Skin moisturizing ability is represented by the improvement in skin moisture content; skin soothing ability is represented by the improvement in a* value and itch score; and skin barrier repair ability is represented by the improvement in TEWL value. These are calculated using the following formulas: Skin moisture content improvement rate = (moisture content) T28 - Moisture content T0 ) / Moisture content T0 ×100%; a* value improvement rate = (a* value) T0 -a* value T28 ) / a*value T0 ×100%; TEWL value improvement rate = (TEWL value) T0 -TEWL value T28 ) / TEWL value T0 ×100%; Improvement rate of pruritus score = (pruritus score) T0 - Itching score T28 ) / Itching score T0 ×100%; The calculation results are averaged, as shown in Table 6.

[0093] Table 6 The results are shown in Table 6. The face creams prepared using the repair composition of this application showed better skin moisturizing, skin soothing, and skin barrier repair capabilities. Among them, the face creams of Application Examples 1-14 showed improvement rates of 40.3%-55.7% in moisture content, 20.5%-30.2% in a* value, 16.5%-22.4% in TEWL value, and 63.1%-92.8% in pruritus score. A comparison of the facial redness area between Application Example 6 and the blank application example is shown below. Figure 1 As shown.

[0094] As can be seen from Application Examples 1 to 6, the mass fraction of the components in the repair composition and the mass percentage of some components (camellia extract, camellia PDRN) in the repair composition will affect the overall performance of the repair composition. When the mass fraction of the components is further selected within the range given in this application, the repair composition added to the face cream has better overall performance and can better improve the skin's moisturizing, skin soothing and skin barrier repair capabilities.

[0095] From Application Examples 6 and 7-10, it is evident that the parameter selection in the preparation method of camellia PDRN also affects the overall effect of the repair composition. Using the camellia PDRN preparation method of this application allows for better extraction of the active ingredient, camellia PDRN, which, when added to the repair composition, can better enhance skin hydration, skin soothing, and skin barrier repair capabilities when added to a face cream. In contrast, Application Example 11, which uses a conventional DNA extraction method, yields a repair composition that, when applied to a face cream, shows poorer effects in improving skin hydration, skin soothing, and skin barrier repair.

[0096] As can be seen from Application Examples 6 and 11-12, the improvement rates of moisture content, a* value, TEWL value, and pruritus score of the repair compositions in Application Examples 11-12 were slightly lower. The selection of parameters in the components also affects the overall performance of the repair composition. The repair composition of this application uses galactoglucan within the above molecular weight range. Galactoglucan has excellent hygroscopicity and forms a breathable protective film on the skin surface, synergistically moisturizing and repairing the barrier, helping the skin resist dry environments, improving the physical cold resistance of the repair composition, and increasing the transdermal absorption of other active ingredients such as camellia extract and camellia PDRN. When the obtained repair composition is applied to a face cream, it can better improve the skin's moisturizing, skin soothing, and skin barrier repair capabilities.

[0097] As can be seen from Application Example 6 and Comparative Application Examples 1-8, when one of the components is not added, or when one component is added to another component without its addition, the improvement rates of moisture content, a* value, TEWL value, and pruritus score of the repair composition are all poor. This indicates that the repair composition of this application contains camellia extract, camellia seed oil, camellia PDRN, galactoglucan, and European chestnut leaf extract in appropriate weight ranges. The repair composition effectively resists skin damage caused by the cold winter environment by activating heat shock proteins, inhibiting the cold receptor TRPM8, improving microcirculation, and building a physical barrier for the skin. It alleviates problems such as redness, itching, scaling, and cracking of the skin, and has the effects of highly effective moisturizing, soothing, and repairing. It is also gentle and non-irritating, making it suitable for people with sensitive skin. By comparing application example 6 with comparative application examples 1-3, it can be seen that the camellia extract, camellia seed oil and camellia PDRN in the repair composition work synergistically to simulate and enhance the skin cells' adaptation mechanism in cold from different dimensions. The above three components are homologous, which makes them inherently complementary and synergistic. Together, they improve the skin's cold resistance from three aspects: cell membrane fluidity, antioxidant defense and energy homeostasis, and enhance the effect of resisting skin damage caused by the harsh winter environment. This allows the applied face cream to better improve the skin's moisturizing, skin soothing and skin barrier repair capabilities.

[0098] By comparing application example 6 with comparative application examples 2 and 4, it can be seen that the lipid membranes of galactoglucan and camellia seed oil can form a "water-oil double membrane" structure, achieving the effects of water locking and moisturizing, jointly resisting dry environments, enhancing the integrity of the barrier, and better improving the physical cold resistance of the product. The product has better skin moisturizing, skin soothing, and skin barrier repair capabilities.

[0099] As can be seen from Comparative Application Example 6, Comparative Application Examples 9-10, and Comparative Application Examples 12-14, when other components are used to replace the components in the repair composition of this application, the effect of the product also shows a certain downward trend. This indicates that the specific components such as camellia extract, camellia seed oil, camellia PDRN, galactoglucan, and European chestnut leaf extract used in this application can effectively improve the product's ability to moisturize the skin, soothe the skin, and repair the skin barrier.

[0100] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application and are not intended to limit the scope of protection of this application. Although this application has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of this application without departing from the substance and scope of the technical solutions of this application.

Claims

1. A repair composition, characterized in that, The repair composition comprises the following components in parts by weight: Camellia flower extract 0.5-7 parts, camellia seed oil 1-15 parts, camellia PDRN 0.01-1 part, galactoglucan 0.005-0.4 parts and European chestnut leaf extract 0.01-2 parts.

2. The repair composition as claimed in claim 1, characterized in that, The repair composition comprises the following components in parts by weight: Camellia flower extract 1-5 parts, camellia seed oil 3-10 parts, camellia PDRN 0.05-0.5 parts, galactoglucan 0.01-0.2 parts and European chestnut leaf extract 0.1-1 parts.

3. The repair composition as claimed in claim 1, characterized in that, The total mass of the camellia extract and camellia PDRN accounts for 10-30% of the mass of the repair composition.

4. The repair composition as claimed in claim 1, characterized in that, The molecular weight of the galactoglucan is 100~5000kDa.

5. The repair composition as claimed in claim 1, characterized in that, The method for preparing camellia PDRN includes the following steps: S1. Take camellia flowers, dry them, grind them into powder, and sieve them to obtain camellia powder; S2. Add the camellia powder from step S1 to a buffer solution containing polyvinylpyrrolidone for ultrasonic extraction, centrifuge, and collect the supernatant. S3. Add anhydrous ethanol to the supernatant in step S2 to precipitate, collect the precipitate, wash, centrifuge, take the precipitate, and dry to obtain camellia PDRN.

6. The repair composition as claimed in claim 5, characterized in that, In step S2, the buffer solution includes Tris-HCl buffer; the mass concentration of polyvinylpyrrolidone in the buffer solution is 1~3 g / mL. And / or, the ratio of the camellia powder to the buffer solution is 1 g: (10~30) mL.

7. The repair composition as claimed in claim 5, characterized in that, In step S2, the ultrasonic extraction power is 400~600W, the ultrasonic extraction temperature is 25~50℃, and the ultrasonic extraction time is 30~60min.

8. The method for preparing the repair composition according to any one of claims 1 to 7, characterized in that, Includes the following steps: Camellia flower extract, camellia seed oil, camellia PDRN, galactoglucan, and European chestnut leaf extract were mixed to obtain a repairing composition.

9. The use of the repair composition according to any one of claims 1 to 7 in the preparation of cosmetics.

10. A cosmetic product, characterized in that, The cosmetic product includes a face cream, which comprises the following components by weight percentage: Thickener 0.05-0.5%, humectant 0.5-3%, pH adjuster 0.01-0.3%, oil phase 3-15%, preservative 0.5-2%, repair composition according to any one of claims 1-7 5-15%, deionized water balance.

Images