Blood treatment equipment and blood treatment system

Abstract

The invention provides blood treatment equipment and a blood treatment system.The blood treatment equipment comprises an equipment body and an operation display screen, and the equipment body is provided with a pump set, a pipeline valve and a controller; the pump set comprises a blood pump used for conveying blood to the blood path, a medicine liquid pump used for conveying medicine liquid or plasma to the medicine liquid path and a waste liquid pump used for conveying waste liquid to the waste liquid path, and the multiple medicine liquid pumps are used for conveying medicine liquid to the multiple different medicine liquid paths. The operation display screen is provided with an input module and transmits instructions to the controller so that the controller can regulate and control the operation states of the liquid medicine pumps and the conduction conditions of the pipeline valves, liquid medicine can be conveyed to different positions of the blood path through different liquid medicine paths, and therefore multiple treatment modes can be achieved. Through cooperation of the pump set and the pipeline valve, liquid medicine can be conveyed to different positions of the blood path through different liquid medicine paths, multiple treatment modes can be conveniently achieved, and the convenience of the blood treatment equipment in application is improved.

Description

Technical Field

[0001] The present application relates to the technical field of medical equipment, and in particular to a blood treatment device and a blood treatment system including the blood treatment device. Background Art

[0002] Blood therapy is a treatment method that removes harmful substances from the blood through a purifier such as a dialyzer, adsorbent or separator, and then returns the purified blood to the body. Currently, there are many types of blood therapy modes in medicine, such as hemodialysis, hemofiltration, hemodiafiltration, hemoperfusion, plasma exchange, plasma adsorption, immunoadsorption, albumin dialysis, etc. However, only a few treatment modes can be achieved on a traditional single blood therapy device, resulting in the need to equip a treatment room such as an ICU or operating room with multiple blood therapy devices for replacement or combination use, which is not convenient enough. Summary of the invention

[0003] In view of this, the present application is dedicated to providing a blood treatment device, which, through the cooperation of a pump group and a pipeline valve, can deliver medicine to different positions of the blood path through different medicine paths, conveniently realize multiple treatment modes, increase the types of treatment modes that can be achieved on the same device, and improve the convenience of blood treatment equipment in application.

[0004] The present application provides a blood treatment device, including a device body and an operation display screen, wherein the device body is provided with a pump group, a pipeline valve and a controller; the pump group includes a blood pump for conveying blood to a blood path, a drug pump for conveying drug solution or plasma to a drug solution path, and a waste liquid pump for conveying waste liquid to a waste liquid path, and the drug solution pump has multiple and is used to convey drug solution to multiple different drug solution paths; the operation display screen has an input module, through which instructions are transmitted to the controller so that the controller regulates the operating status of each of the drug solution pumps and the conductance of the pipeline valves, and can convey drug solution to different positions of the blood path through different drug solution paths to achieve multiple treatment modes.

[0005] Optionally, the drug liquid pump includes a first liquid pump, and the pipeline valve includes a first valve, and the first valve is used to switch between a first path and a second path; by adjusting the path conducted by the first valve and the drug liquid path of the first liquid pump, three treatment modes can be formed.

[0006] Optionally, the three treatment modes are dilution before hemofiltration, dilution after hemofiltration and hemodialysis. In the hemodialysis mode, the controller starts the first liquid pump and enables the first valve to conduct the first path, and the first liquid pump is used to input liquid medicine to an external therapeutic device on the blood path through a liquid medicine path where the first path is located; in the dilution before hemofiltration mode, the controller starts the first liquid pump and enables the first valve to conduct the second path, and the first liquid pump is used to transport liquid medicine to the upstream of the external therapeutic device on the blood path through a liquid medicine path where the second path is located; in the dilution after hemofiltration mode, the controller starts the first liquid pump and enables the first valve to conduct the second path, and the first liquid pump is used to transport liquid medicine to the downstream of the external therapeutic device on the blood path through a liquid medicine path where the second path is located.

[0007] Optionally, the medicine liquid pump also includes a second liquid pump, and the pipeline valve also includes a second valve, and the second valve is used to connect the third path and the fourth path; by adjusting the path connected by the first valve and the second valve and the medicine liquid path of the first liquid pump and the second liquid pump, three treatment modes can be formed.

[0008] Optionally, the other three treatment modes are hemofiltration mixed dilution, dilution before hemodiafiltration, and dilution after hemodiafiltration; in the hemofiltration mixed dilution mode, the controller starts the first liquid pump and the second liquid pump and makes the first valve conduct the second path and the second valve conduct the fourth path, the first liquid pump is used to transport the drug solution to the downstream of the external therapeutic device through a drug solution path where the second path is located, and the second liquid pump is used to transport the drug solution to the external therapeutic device through a drug solution path where the fourth path is located; in the pre-hemodiafiltration dilution mode, the controller starts the first liquid pump and the second liquid pump and makes the first valve conduct the first path, The second valve is connected to the fourth path, the first liquid pump is used to deliver liquid medicine to the external therapeutic device through a liquid medicine path where the first path is located, and the second liquid pump is used to deliver liquid medicine to the upstream of the external therapeutic device through a liquid medicine path where the fourth path is located; in the pre-hemodiafiltration dilution mode, the controller starts the first liquid pump and the second liquid pump and enables the first valve to connect the first path and the second valve to connect the fourth path, the first liquid pump is used to deliver liquid medicine to the external therapeutic device through a liquid medicine path where the first path is located, and the second liquid pump is used to deliver liquid medicine to the downstream of the external therapeutic device through a liquid medicine path where the fourth path is located.

[0009] Optionally, the drug liquid pump also includes a third liquid pump, which can form a drug liquid path in a hemodiafiltration mixed dilution mode by starting the first liquid pump, the second liquid pump and the third liquid pump, and connecting the first path and the fourth path; in this mode, the first liquid pump is used to input drug liquid into an external therapeutic device on the blood path, the second liquid pump is used to input drug liquid into a tube for returning blood connected to the downstream of the external therapeutic device, and the third liquid pump is used to input drug liquid into a tube for collecting blood upstream of the external therapeutic device.

[0010] On the other hand, the present application also provides a blood treatment system, including a blood treatment device as described in any of the above items, and an external consumable for connecting to the blood treatment device, the external consumable including an external pipe and an external treatment device, and the external consumable forms the blood path, the waste liquid path and the plurality of drug liquid paths.

[0011] Optionally, the external pipeline includes a first sleeve, which includes: a blood basic tube, which can be detachably arranged on the blood pump, including a blood collection basic tube and a blood return basic tube connected to the external therapeutic device; a first drug liquid basic tube, which can be detachably arranged on the first liquid pump, and is used to be connected to any one or any combination of the external therapeutic device, the blood collection basic tube upstream of the external therapeutic device, and the blood return basic tube downstream of the external therapeutic device through the pipeline valve; a second drug liquid basic tube, which can be detachably arranged on the second liquid pump, one end of which is used to be connected to the first drug liquid basic tube, and the other end of which is used to be connected to the blood collection basic tube and / or the blood return basic tube; a waste liquid basic tube, which can be detachably arranged on the waste liquid pump, one end of which is used to be connected to the output end of the external therapeutic device, and the other end of which is used to be connected to a waste liquid bag.

[0012] Optionally, the first medicine liquid basic tube includes a first main tube connected to the medicine liquid bag and a first branch tube and a second branch tube connected to the first main tube, the first branch tube is used to be connected to the external therapeutic device, and the second branch tube is used to be connected to the blood collection basic tube or the blood return basic tube; the second medicine liquid basic tube includes a second main tube and a third branch tube and a fourth branch tube connected to the second main tube, the second main tube is connected to the first main tube through a joint, the third branch tube is connected to the second branch tube so as to be connected to the blood collection basic tube through the second branch tube, and the fourth branch tube is used to be connected to the blood collection basic tube or the blood return basic tube.

[0013] Optionally, the external pipeline includes a second sleeve, and the second sleeve includes: a blood basic tube and a waste liquid basic tube in the first sleeve; a fourth drug liquid basic tube, which can be detachably arranged on the first liquid pump, one end of which is connected to the drug liquid bag and the other end is used to be connected to the external therapeutic device or the blood return basic tube; a fifth drug liquid basic tube, which can be detachably arranged on the second liquid pump, used to be connected to the blood return basic tube, or used to be connected between two external therapeutic devices; a first connecting tube, connected to the input end of the external therapeutic device A, used to connect the external therapeutic device A and other external therapeutic devices or basic tubes; a second connecting tube, connected to the output end of the external therapeutic device A, including a third main pipe and a fifth branch pipe and a sixth branch pipe connected to the third main pipe through the pipeline valve; a plurality of auxiliary connecting tubes are provided.

[0014] The blood treatment device provided in the present application has a pump group including multiple pumps for providing power for each path in different modes. Different drug liquid paths can be formed by enabling and regulating each pump and adjusting the conductance of the pipeline valves, and the drug liquid can be delivered to different positions of the blood path, thereby realizing multiple treatment modes, thereby integrating multiple treatment modes on one blood treatment device, improving the integration and ease of use of the blood treatment device. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 Shown is a schematic diagram of a device body of a blood treatment device in an embodiment of the present application;

[0016] Figure 2 Shown is a schematic diagram of a pump group in an embodiment of the present application;

[0017] Figure 3 The figure shows a schematic diagram of the drug solution path in the hemodialysis mode in the embodiment of the present application;

[0018] Figure 4 The figure shows a schematic diagram of the liquid path of the blood filtration mixing dilution mode in the embodiment of the present application;

[0019] Figure 5 The figure shows a schematic diagram of the drug solution path in the dilution mode before hemodiafiltration in the embodiment of the present application;

[0020] Figure 6 The figure shows a schematic diagram of the drug solution path in the dilution mode after hemodiafiltration in an embodiment of the present application;

[0021] Figure 7 The figure shows a schematic diagram of the drug solution path in the hemodiafiltration mixed dilution mode in the embodiment of the present application;

[0022] Figure 8 Shown is a schematic diagram of a first sleeve in an embodiment of the present application;

[0023] Fig. 9 Shown is a schematic diagram of the structure of some of the basic tubes for liquid medicine in the embodiments of the present application;

[0024] Fig.10 Shown is a schematic diagram of the pipeline of the plasma filtration dialysis mode in the embodiment of the present application;

[0025] Fig.11 Shown is a schematic diagram of the pipeline of the dual plasma molecule adsorption system mode in the embodiment of the present application;

[0026] Fig.12 Shown is a schematic diagram of the pipeline of the paired plasma filtration adsorption mode in the embodiment of the present application;

[0027] Fig.13 Shown is a schematic diagram of the pipeline of the plasma separation adsorption system mode in the embodiment of the present application;

[0028] Fig.14 Shown is a schematic diagram of the pipeline of the molecular adsorption recycling system mode in the embodiment of the present application;

[0029] Fig.15 Shown is a schematic diagram of the pipeline of the double filtration plasma exchange mode in the embodiment of the present application.

[0030] Figure 1-Figure 15 middle:

[0031] 50. Equipment body; 51. Operation display screen; 1. First liquid pump; 2. Second liquid pump; 3. Third liquid pump; 4. Blood pump; 5. Waste liquid pump; 6. First valve; 7. Second valve;

[0032] Blood basic tube; 11. Blood collection basic tube; 12. Blood return basic tube; 20. Waste liquid basic tube;

[0033] 31, first liquid medicine basic tube; 311, first main tube; 312, first branch tube; 313, second branch tube; 32, second liquid medicine basic tube; 321, second main tube; 322, third branch tube; 323, fourth branch tube; 33, third liquid medicine basic tube; 34, fourth liquid medicine basic tube; 35, fifth liquid medicine basic tube;

[0034] 41. First connecting pipe; 42. Second connecting pipe; 421. Third main pipe; 422. Fifth branch pipe; 423. Sixth branch pipe; 43. Third connecting pipe; 44. Fourth connecting pipe; 45. Fifth connecting pipe. DETAILED DESCRIPTION

[0035] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0036] Please refer to the attached Figure 1-Figure 15 An embodiment of the present application provides a blood treatment device, including a device body 50 and an operation display screen 51, and a pump group, a pipeline valve and a controller are arranged on the device body 50; the pump group includes multiple pumps, specifically including a blood pump 4 for conveying blood, a drug pump for conveying drug solution or plasma and a waste liquid pump 5 for conveying waste liquid, and there are multiple drug liquid pumps; the pump group is used to act on external consumables to convey liquid for the blood path, waste liquid path and multiple drug liquid paths formed by the external consumables. For example, the external consumables include an external pipeline and an external therapeutic device. The pipeline for collecting blood from the human body and the pipeline for transporting blood back to the human body are combined with the external therapeutic device to form a blood path, that is, the blood path has an external therapeutic device, a blood collection blood path located upstream of the external therapeutic device, and a blood return blood path located downstream of the external therapeutic device. The liquid medicine pipeline connects the liquid medicine bag and the blood path to form a liquid medicine path, and the waste liquid pipeline connects the external therapeutic device and the waste liquid bag to form a waste liquid path. The operation of each liquid medicine pump and the conduction of the pipeline valve are regulated, and the liquid medicine is transported to different positions of the blood path through different liquid medicine paths to form a variety of treatment modes. In each mode, the blood pump 4 and the waste liquid pump 5 are both in operation.

[0037] At the same time, the operation display screen 51 has an input module, and the controller can be transmitted with instructions through the input module to enable the controller to adjust the pipeline valve to switch the pipeline conduction to form different liquid medicine paths, and adjust the operating state of each pump in the pump group to transport the liquid medicine to the required liquid medicine path, so that multiple treatment modes can be realized. For example, without changing the pipeline, only the eight modes of hemodialysis filtration can be realized by adjusting the pipeline valve and the pump group, and other treatment modes, such as eleven modes of plasma treatment, only need to replace the external treatment device and the connecting pipe corresponding to the external treatment device to adjust the pipeline valve and the pump group to achieve. It can be seen that the blood treatment device provided by the present application can form a variety of liquid medicine paths and realize a variety of treatment modes by setting a large number of pumps and pipeline valves with distinct functions, so that more treatment modes are integrated on a blood treatment device. In practical applications, a variety of treatment modes can be selected and used through a blood treatment device, thereby improving the integration and convenience of use of the blood treatment device.

[0038] The liquid medicine pump may be provided with one, two or three liquid pumps. Preferably, the liquid medicine pump includes three liquid pumps, which are recorded as a first liquid pump 1, a second liquid pump 2 and a third liquid pump 3. The more liquid pumps there are, the more liquid medicine paths that can be realized, and the more treatment modes that can be realized. The pipeline valve may be provided with one or two. Preferably, the pipeline valve includes a first valve 6 and a second valve 7.

[0039] Specifically, in some embodiments, the blood treatment device has a first liquid pump 1 and a first valve 6, the first valve 6 is used to switch the first path and the second path, the first path and the second path belong to two drug liquid paths, respectively, and are local sections in the drug liquid path. By adjusting the path conducted by the first valve 6 and the drug liquid path of the first liquid pump 1, three treatment modes can be formed. The three treatment modes are dilution before blood filtration, dilution after blood filtration, and hemodialysis.

[0040] In the hemodialysis mode, the controller starts the first liquid pump 1 and enables the first valve 6 to conduct the first path. The first liquid pump 1 is used to input liquid medicine from the liquid medicine bag to the external therapeutic device on the blood path through a liquid medicine path where the first path is located.

[0041] In the pre-hemofiltration dilution mode, the controller starts the first liquid pump 1 and enables the first valve 6 to connect to the second path. The first liquid pump 1 is used to transport the liquid medicine from the liquid medicine bag to the upstream of the external therapeutic device on the blood path (i.e., the tube located upstream of the external therapeutic device, such as the blood collection blood path, the same below) through a liquid medicine path where the second path is located.

[0042] In the dilution mode after blood filtration, the controller starts the first liquid pump 1 and enables the first valve 6 to conduct the second path. The first liquid pump 1 is used to transport the liquid medicine from the liquid medicine bag to the blood path downstream of the external therapeutic device (i.e., the tube downstream of the external therapeutic device, such as the blood return path, the same below) through a liquid medicine path where the second path is located.

[0043] In some embodiments, the liquid medicine pump includes a first liquid pump 1 and a second liquid pump 2, and the pipeline valve includes a first valve 6 and a second valve 7, and the second valve 7 is used to conduct the third path and the fourth path; by adjusting the path conducted by the first valve 6 and the second valve 7 and the liquid medicine path of the first liquid pump 1 and the second liquid pump 2, three treatment modes can be formed. The three treatment modes are hemofiltration mixed dilution, hemodiafiltration pre-dilution and hemodiafiltration post-dilution.

[0044] In the blood filtration mixed dilution mode, the controller starts the first liquid pump 1 and the second liquid pump 2 and makes the first valve 6 conduct the second path and the second valve 7 conduct the fourth path. The first liquid pump 1 is used to transport the drug solution to the downstream of the external therapeutic device through a drug solution path where the second path is located, and the second liquid pump 2 is used to transport the drug solution to the external therapeutic device on the blood path through a drug solution path where the fourth path is located.

[0045] In the dilution mode before hemodiafiltration, the controller starts the first liquid pump 1 and the second liquid pump 2 and makes the first valve 6 conduct the first path and the second valve 7 conduct the fourth path. The first liquid pump 1 is used to deliver the drug solution to the external therapeutic device through a drug solution path where the first path is located, and the second liquid pump 2 is used to deliver the drug solution to the upstream of the external therapeutic device on the blood path through a drug solution path where the fourth path is located.

[0046] In the dilution mode before hemodiafiltration, the controller starts the first liquid pump 1 and the second liquid pump 2 and makes the first valve 6 conduct the first path and the second valve 7 conduct the fourth path. The first liquid pump 1 is used to deliver the drug solution to the external therapeutic device through a drug solution path where the first path is located, and the second liquid pump 2 is used to deliver the drug solution to the downstream of the external therapeutic device through a drug solution path where the fourth path is located.

[0047] By starting the blood pump 4 and the waste liquid pump 5 and shutting down the liquid medicine pump, a treatment mode, namely the slow continuous ultrafiltration treatment mode, can also be achieved. The blood pump 4 is used to make blood flow through the external therapeutic device, and the waste liquid pump 5 is used to transport the waste liquid output by the external therapeutic device to the waste liquid bag.

[0048] In this way, the blood treatment equipment provided by the present application can realize the above-mentioned eight treatment modes of hemodialysis and filtration through the setting of two valves, three drug pumps, a blood pump 4 and a waste liquid pump 5; and in the case of replacing external consumables, by regulating the various pumps and pipeline valves, eleven treatment modes of plasma therapy can also be realized (see below for details), so that the blood treatment equipment can cooperate with the use of external consumables to realize nineteen treatment modes, thereby improving the integration and ease of use of the blood treatment equipment.

[0049] The embodiment of the present application also provides a blood treatment system, which includes the above-mentioned blood treatment device and external consumables for connecting to the blood treatment device. The external consumables include external pipes and external therapeutic devices, and these external consumables form a blood path, a waste liquid path, and a drug liquid path on which the above-mentioned pump group and pipeline valves act. In this way, the blood treatment system is highly integrated and can realize multiple blood treatment modes.

[0050] Specifically, in the present application, the external pipeline includes multiple basic tubes and multiple connecting tubes. The basic tubes are connected to each pump in the pump group, and the connecting tubes are set corresponding to the external therapeutic device, which is used to connect two external therapeutic devices or connect the external therapeutic device to the basic tubes. Some tubes are connected to the pipeline valves. The basic tubes and the basic tubes and connecting tubes can be used in combination with each other to form a liquid flow path of multiple treatment modes. Each tube and the external therapeutic device are provided with multiple input connectors and output connectors for connecting or splitting with any other tubes.

[0051] The external pipeline includes a first sleeve and / or a second sleeve. The first sleeve includes a plurality of connected basic tubes, and the plurality of basic tubes are fixedly matched one-to-one with the plurality of pumps in the pump group. Some basic tubes are connected to the pipeline valves. By regulating the pipeline valves to regulate the conduction between these basic tubes, a variety of liquid flow paths can be formed. By regulating the operating state of each pump in the pump group, the liquid delivery on the required path can be achieved, thereby achieving a variety of liquid flow paths for treatment modes, such as the eight modes of hemodialysis filtration. The eight modes of hemodialysis filtration can be achieved by regulating the pipeline valves and pumps without changing the tubes, which effectively simplifies the operation, improves the convenience of use, and can effectively reduce the operational errors of medical staff when installing the external pipeline on the device body. The second set of tubes includes a plurality of basic tubes corresponding to the pumps in the pump group and a plurality of connecting tubes corresponding to the external therapeutic device. By replacing the connecting tubes connected to the basic tubes and the external therapeutic device, the plurality of basic tubes and the plurality of connecting tubes can be switched and combined to realize the liquid flow paths of various treatment modes. By regulating the conductance of the pipeline valves and the operating state of each pump in the pump group, the liquid can be transported on the required path, thereby forming a variety of other treatment modes, such as eleven modes of plasma therapy.

[0052] It can be seen that the blood treatment system can be said to integrate more treatment modes on a single blood treatment device. In actual applications, a single blood treatment device can be used to select and use a variety of treatment modes, thereby improving the integration and ease of use of the blood treatment device; and through the setting of the external piping, it can be easily used with the pump and pipeline valve, and the pipeline installation operation can also be simplified, which effectively simplifies the use of blood treatment, improves ease of use, shortens the operation preparation time, and can effectively reduce the operational errors of medical staff when installing the external piping on the device body.

[0053] Specifically, the first set of tubes includes a blood basic tube 10 for blood collection and blood return; the blood basic tube 10 is used to connect an external therapeutic device, and the blood basic tube 10 and the external therapeutic device form a blood path. The blood basic tube 10 is used to be detachably connected to the blood pump 4 and is arranged corresponding to the blood pump 4. Through the power transmission of the blood pump 4, the blood drawn from the human body is sent to the external therapeutic device for treatment, and then the treated blood is transported back to the human body. In detail, the blood basic tube 10 includes a blood collection basic tube 11 and a blood return basic tube 12. The blood collection basic tube 11 is detachably arranged on the blood pump 4, and one end is used to be connected to the blood collection puncture needle on the patient, and the other end is used to be connected to the input connector of the external therapeutic device. One end of the blood return basic tube 12 is used to be connected to the output connector of the external therapeutic device, and the other end is used to be connected to the return puncture needle on the patient. The blood collection basic tube 11 and the blood return basic tube 12 are also provided with multiple input connectors for connecting other tubes.

[0054] After the blood basic tube 10 is fixed to the device main body 50, for example, it is fixed to the device main body 50 by a fixed tube structure such as a tube clamp or a buckle, and the external therapeutic device is set between the blood collection basic tube 11 and the blood return basic tube 12. The blood collection basic tube 11 is connected to the input end of the external therapeutic device and is connected to the input connector of the external therapeutic device, and the blood return basic tube 12 is connected to the output end of the external therapeutic device and is connected to the output connector of the external therapeutic device.

[0055] When the external therapeutic device is a perfusion device, the blood perfusion mode can be realized by combining the blood collection basic tube 11 and the perfusion device and starting the blood pump 4. In the blood perfusion mode, the perfusion device is connected between the blood collection basic tube 11 and the blood return basic tube 12, and the blood is pumped by the blood pump 4 so that the blood is drawn out of the human body and then flows into the perfusion device, and then flows into the blood return basic tube 12, and then flows back to the human body.

[0056] The first sleeve also includes a waste liquid basic tube 20 for being detachably connected to the waste liquid pump 5 and arranged corresponding to the waste liquid pump 5, that is, the waste liquid basic tube 20 is only arranged on the waste liquid pump 5, one end of which is used to be connected to the output connector of the external therapeutic device, and the other end is connected to the waste liquid bag for holding waste liquid, and is used to transport the waste liquid discharged by the external therapeutic device into the waste liquid bag. The waste liquid basic tube 20 is always connected to the output end of the external therapeutic device, connected to the output connector of the external therapeutic device, and forms a waste liquid path. When there are multiple external therapeutic devices, the waste liquid basic tube 20 is connected to the external therapeutic device that finally outputs the waste liquid.

[0057] The first tube set and the second tube set both include a blood basic tube 10 and a waste liquid basic tube 20 .

[0058] In addition, the first casing also includes other basic tubes, and the number of basic tubes in the first casing matches the number of liquid medicine pumps in the pump group. When there are two liquid medicine pumps, namely the first liquid pump 1 and the second liquid pump 2, the first casing also includes a first liquid medicine basic tube 31 corresponding to the first liquid pump 1 and a second liquid medicine basic tube 32 corresponding to the second liquid pump 2. When there are three liquid medicine pumps, namely the first liquid pump 1, the second liquid pump 2 and the third liquid pump 3, the first casing includes not only the first liquid medicine basic tube 31 and the second liquid medicine basic tube 32, but also the third liquid medicine basic tube 33 corresponding to the third liquid pump 3. The first liquid medicine basic tube 31 and the first liquid pump 1 are detachably connected, that is, the first liquid medicine basic tube 31 is detachably arranged on the first liquid pump 1; the second liquid medicine basic tube 32 is detachably arranged on the second liquid pump 2, and the third liquid medicine basic tube 33 is detachably arranged on the third liquid pump 3. Each pump in the pump group can be a peristaltic pump.

[0059] The multiple tubes in the external pipeline are classified and set according to their functions. The functions of each tube are clear, and each tube has its own matching connection object. Not only can they have exclusive fixed positions on the device body 50, which is convenient for disassembly and fixation, but the combination use corresponding to each mode is also very clear, which is convenient for setting, and is conducive to improving the convenience of switching the pipeline when changing the mode; moreover, each tube with a clear function and set separately is equivalent to a standard part. When the treatment object changes, that is, the patient is changed, the pipeline used by the previous patient can be directly replaced, and the pipeline not used by the previous patient can be retained and combined with the new pipeline, so as to avoid waste of resources, help save costs, and improve the convenience of disassembly and replacement of the pipeline.

[0060] One end of the first drug liquid basic tube 31 is used to connect to the drug liquid bag, and the other end is used to connect to any one or any combination of the external treatment device, the blood collection basic tube 11, and the blood return basic tube 12 through a pipeline valve (specifically, the first valve 6); by activating the first liquid pump 1 and adjusting the conduction of the pipeline valve, the drug liquid can be delivered to any one or any combination of the external treatment device, the blood collection basic tube 11 upstream of the external treatment device, and the blood return basic tube 12 downstream of the external treatment device. One end of the second drug liquid basic tube 32 is used to connect to the first drug liquid basic tube 31, and the other end is used to connect to the blood collection basic tube 11 and / or the blood return basic tube 12 through a pipeline valve (specifically, the second valve 7). By activating the first liquid pump 1 and adjusting the conduction of the pipeline valve, the drug liquid can be introduced from the first drug liquid basic tube 31 and then delivered to the blood collection basic tube 11 and / or the blood return basic tube 12. One end of the third medicine liquid basic tube 33 is used to be connected to the first medicine liquid basic tube 31, and the other end is used to be connected to the blood collection basic tube 11. By activating the third liquid pump 3, the medicine liquid can be introduced from the first medicine liquid basic tube 31 and then transported to the blood collection basic tube 11.

[0061] In this way, by adjusting the pipeline valve to select different liquid paths formed by the conductivity of the liquid base tube, and by starting or shutting down the three liquid pumps to transport the liquid through different liquid paths, a variety of different treatment modes can be achieved.

[0062] It should be noted that the external therapeutic device is usually a dialyzer, a plasma separator, an adsorber or a filter, etc. The cavity is divided into two sides by a semipermeable membrane, one of which can be called the blood side and the other can be called the dialysis side. In each treatment mode, the blood collection basic tube 11 and the blood return basic tube 12 are both connected to the blood side, and the drug liquid basic tube and the waste liquid basic tube 20 are both connected to the dialysis side; if the drug liquid flows directly into the blood collection basic tube 11 through the drug liquid basic tube, the drug liquid is mixed with the blood to be treated and enters the blood side together, while the drug liquid that directly enters the external therapeutic device through the drug liquid basic tube enters the dialysis side. If the drug liquid flows directly into the blood return basic tube 12 through the drug liquid basic tube, the drug liquid is mixed with the blood after treatment and flows back to the human body together.

[0063] Specifically, the three basic tubes for medical liquids are combined with the basic tube for blood collection 11 and the basic tube for waste liquid 20, and eight treatment modes in terms of hemodialysis and filtration can be realized by switching the conduction conditions. The eight treatment modes are: dilution before hemofiltration, dilution after hemofiltration, mixed dilution before and after hemofiltration, hemodialysis, dilution before hemodiafiltration, dilution after hemodiafiltration, mixed dilution of hemodiafiltration, and slow continuous ultrafiltration.

[0064] In the eight treatment modes, each external treatment device is provided with one, and each is arranged between the blood collection basic tube 11 and the blood return basic tube 12, and the waste liquid basic tube 20 is always connected to the output end of the external treatment device.

[0065] The waste liquid basic tube 20 is combined with the blood basic tube 10, and the blood pump 4 and the waste liquid pump 5 are activated, so that a liquid flow path of the slow continuous ultrafiltration treatment mode can be formed. The dialyzer is set on the blood basic tube 10, the waste liquid basic tube 20 is connected to the output connector of the dialyzer, the blood pump 4 is started to transport blood through the dialyzer, so that the dialyzed blood flows back to the human body, and the waste liquid pump 5 is activated to transport the dialyzed waste liquid to the waste liquid bag, so that the slow continuous ultrafiltration mode can be achieved.

[0066] like Figure 2 and Figure 8 As shown, exemplarily, the first drug solution basic tube 31 includes a first main tube 311 for connecting to a drug solution bag and a first branch tube 312 and a second branch tube 313 connected to the first main tube 311 through a first valve 6. The first branch tube 312 is used to connect to an external therapeutic device, and the second branch tube 313 is used to connect to an input connector of the blood collection basic tube 11 or the blood return basic tube 12.

[0067] The controller starts the first liquid pump 1, the blood pump 4 and the waste liquid pump 5, and adjusts the pipeline valve to select the first branch 312 or the second branch 313, and switches the second branch 313 to be connected to the blood collection basic tube 11 or the blood return basic tube 12, so that three treatment modes can be formed. These three treatment modes are pre-hemofiltration dilution (abbreviated as CVVH-pre), post-hemofiltration dilution (abbreviated as CVVH-post) and hemodialysis (abbreviated as CVVHD). In these three modes, the external treatment device is a dialyzer (conventional dialyzer or high-pass dialyzer, collectively referred to as dialyzer in this article), and is connected between the blood collection basic tube 11 and the blood return basic tube 12.

[0068] Start the first liquid pump 1, the second liquid pump 2, the blood pump 4 and the waste liquid pump 5, conduct the second branch pipe 313 through the first valve 6, close the first branch pipe 312, connect the second branch pipe 313 and the blood collection basic tube 11 (that is, connect the end of the second branch pipe 313 to an input connector of the blood collection basic tube 11), so that the pre-blood filtration dilution mode can be realized. In this mode, through the pumping of the blood pump 4, the blood is drawn from the human body and flows into the blood collection basic tube 11 and the dialyzer in sequence; through the pumping of the first liquid pump 1, the drug liquid flows into the blood collection basic tube 11 through the first main pipe 311 and the second branch pipe 313 and flows into the dialyzer together with the blood. After being processed by the dialyzer, the blood flows back to the human body through the blood return basic tube 12, and through the pumping of the waste liquid pump 5, the waste liquid flows into the waste liquid basic tube 20 through the dialyzer, and then flows into the waste liquid bag.

[0069] Start the first liquid pump 1, the second liquid pump 2, the blood pump 4 and the waste liquid pump 5, connect the second branch tube 313 through the first valve 6, close the first branch tube 312 and connect the second branch tube 313 to the blood return basic tube 12 (for example, remove the end of the second branch tube 313 from the blood collection basic tube 11 and connect it to an input connector of the blood return basic tube 12, or directly connect the second branch tube 313 to the blood return basic tube 12 after replacing the new tube, or use the pipeline valve to close the connection between the second branch tube 313 and the blood collection basic tube 11 and connect the connection between the second branch tube 313 and the blood return basic tube 12), so as to form a post-hemofiltration dilution mode. In this mode, blood is drawn out from the human body through the pumping of the blood pump 4 and flows into the blood collection basic tube 11, and then flows into the blood return basic tube 12 after passing through the dialyzer; through the pumping of the first liquid pump 1, the medicinal solution flows into the blood return basic tube 12 through the first main tube 311 and the second branch tube 313, and flows back to the human body together with the blood after dialyzation.

[0070] Start the first liquid pump 1, the second liquid pump 2, the blood pump 4 and the waste liquid pump 5, connect the first branch pipe 312 and close the second branch pipe 313 through the first valve 6, and the hemodialysis mode can be realized. The medicinal liquid flows into the dialyzer through the first main pipe 311 and the first branch pipe 312, and undergoes a dialysis reaction with the blood flowing into the dialyzer through the blood collection basic tube 11. Then, the waste liquid enters the waste liquid basic tube 20, and the dialyzed blood flows into the blood return basic tube 12.

[0071] For example, Figure 2 and Figure 8 As shown, the second medical liquid basic tube 32 includes a second main tube 321 and a third branch tube 322 and a fourth branch tube 323 connected to the second main tube 321. The second main tube 321 is connected to the first main tube 311 through a joint, for example, connected to the liquid outlet side branch of the first main tube 311. The third branch tube 322 is connected to the second branch tube 313 so that it can be connected to the input joint of the blood collection basic tube 11 through the second branch tube 313. The fourth branch tube 323 is used to be connected to the input joint on the blood collection basic tube 11 or the blood return basic tube 12.

[0072] The first liquid pump 1, the second liquid pump 2, the blood pump 4 and the waste liquid pump 5 are started by the controller, and the third branch 322 or the fourth branch 323 is selectively connected through the second valve 7, and the fourth branch 323 is switched to be connected to the blood collection basic tube 11 or the blood return basic tube 12, so that the liquid flow paths of three treatment modes of blood filtration mixed dilution (abbreviated as CVVH-Mix), dilution before hemodiafiltration (abbreviated as CVVHDF-pre) and dilution after hemodiafiltration (abbreviated as CVVHDF-post) can be formed.

[0073] Start the first liquid pump 1, the second liquid pump 2, the blood pump 4 and the waste liquid pump 5, connect the second branch pipe 313 and the second branch pipe 313 to the blood return basic pipe 12, connect the fourth branch pipe 323 and the fourth branch pipe 323 to the blood collection basic pipe 11, and shut off the second branch pipe 313 and the third branch pipe 322 to form a blood filtration mixed dilution mode; in this mode, through the pumping of the blood pump 4, the blood flows through the blood collection basic pipe 11, the dialyzer and the blood return basic pipe 12 in sequence; through the pumping of the first liquid pump 1, the drug liquid is divided into two paths through the first main pipe 311, one path flows into the blood return basic pipe 12 through the second branch pipe 313, and the other path flows into the second main pipe 321 of the second drug liquid basic pipe 32 through the pumping of the second liquid pump 2 and flows into the blood collection basic pipe 11 through the fourth branch pipe 323.

[0074] Start the first liquid pump 1, the second liquid pump 2, the blood pump 4 and the waste liquid pump 5, connect the first branch pipe 312 and the fourth branch pipe 323, shut off the second branch pipe 313 and the third branch pipe 322, and connect the fourth branch pipe 323 to the blood collection basic tube 11. The drug solution is pumped by the first liquid pump 1 and is divided into two paths through the first main pipe 311. One path flows directly into the dialyzer through the first branch pipe 312, and the other path is pumped by the second liquid pump 2 into the second main pipe 321 of the second drug solution basic tube 32 and flows into the blood collection basic tube 11 through the fourth branch pipe 323. After mixing with the blood, they flow into the dialyzer together. In this way, a dilution mode before hemodiafiltration is formed; or, the first The branch tube 312, the second branch tube 313 and the third branch tube 322 are all connected, the second branch tube 313 is connected to the blood collection basic tube 11, the fourth branch tube 323 is connected to the blood return basic tube 12, the medicine is pumped by the first liquid pump 1 and is divided into three paths through the first main tube 311, one path flows into the dialyzer through the first branch tube 312, the second path flows into the second branch tube 313, the third path flows into the second medicine basic tube 32 through the pumping of the second liquid pump 2 and merges into the second branch tube 313 through the third branch tube 322, the medicine through the second branch tube 313 flows into the blood collection basic tube 11 and mixes with the blood and enters the dialyzer, in this way, the dilution mode before hemodialysis filtration can also be realized.

[0075] Start the first liquid pump 1, the second liquid pump 2, the blood pump 4 and the waste liquid pump 5, connect the first branch pipe 312 and the fourth branch pipe 323, shut off the second branch pipe 313 and the third branch pipe 322, and connect the fourth branch pipe 323 to the blood return basic pipe 12. The drug solution is pumped by the first liquid pump 1 and is divided into two paths through the first main pipe 311. One path flows into the dialyzer through the first branch pipe 312, and the other path flows into the second drug solution basic pipe 32 through the pumping of the second liquid pump 2 and flows into the blood return basic pipe 12 through the fourth branch pipe 323, thereby realizing the dilution mode after hemodialysis filtration.

[0076] The first liquid pump 1, the second liquid pump 2, the third liquid pump 3, the blood pump 4 and the waste liquid pump 5 are started by the controller, and the first branch pipe 312 is connected and the second branch pipe 313 is closed through the first valve 6, the fourth branch pipe 323 is connected and the third branch pipe 322 is closed through the second valve 7, and the fourth branch pipe 323 is connected to the blood return basic pipe 12, so that a liquid flow path of the hemodialysis filtration mixed dilution treatment mode can be formed; in this mode, the drug solution is pumped by the first liquid pump 1 and is divided into three paths through the first main pipe 311, one path flows into the dialyzer through the first branch pipe 312, the second path flows into the blood return basic pipe 12 through the fourth branch pipe 323 through the pumping of the second liquid pump 2, and mixes with the blood flowing out of the dialyzer and flows into the human body together, and the third path flows into the blood collection basic pipe 11 through the pumping of the third liquid pump 3 through the third drug solution basic pipe 33, and mixes with the blood that has not yet been dialyzed and flows into the dialyzer together. That is, in this mode, the first liquid pump 1 is used to input liquid medicine into the dialyzer, the second liquid pump 2 is used to input liquid medicine into the blood return basic tube 12 downstream of the dialyzer, and the third liquid pump 3 is used to input liquid medicine into the blood collection basic tube 11 upstream of the dialyzer.

[0077] In summary, it can be seen that eight blood treatment modes can be achieved through the pump group having five pumps and the first set of tubes having five basic tubes corresponding to the five pumps of the present application.

[0078] The second set of tubes includes two basic tubes for medical liquid and a plurality of connecting tubes. The second set of tubes also includes a blood basic tube 10 and a waste liquid basic tube 20, and at the same time, includes a fourth basic tube for medical liquid 34, a fifth basic tube for medical liquid 35, a first connecting tube 41, a second connecting tube 42 and a plurality of auxiliary connecting tubes.

[0079] The fourth drug solution basic tube 34 can be detachably arranged on the first liquid pump 1 (the first drug solution basic tube 31 and the fourth drug solution basic tube 34 are alternately and optionally arranged on the device body 50), one end of which is used to be connected to the drug solution bag, and the other end of which is used to be connected to the external treatment device or the blood return basic tube 12. By activating the first liquid pump 1, the drug solution can be transported to the external treatment device or the blood return basic tube 12 through the fourth drug solution basic tube 34.

[0080] The fifth medical liquid basic tube 35 can be detachably arranged on the second liquid pump 2 (the second medical liquid basic tube 32 and the fifth medical liquid basic tube 35 are alternately and optionally arranged on the device body 50), and is used to be connected to the blood return basic tube 12, or, to be connected between two external therapeutic devices. When the second liquid pump 2 is activated, the medical liquid can be transported to the blood return basic tube 12 through the fifth medical liquid basic tube 35, or the blood in the first external therapeutic device can be transported to the second external therapeutic device.

[0081] The first connecting tube 41 is connected to the input end of the external therapeutic device A such as an adsorber, and is used to connect the external therapeutic device A-adsorber to the pipeline and connect to other external therapeutic devices or basic tubes. For example, one end of the first connecting tube 41 is connected to the input end of the external therapeutic device A-adsorber, and the other end is used to connect the fifth liquid basic tube 35 or other external therapeutic devices such as a dialyzer.

[0082] The second connecting tube 42 is connected to the output end of the external therapeutic device A-adsorber, and is used to connect to other external therapeutic devices or the blood return basic tube 12. Specifically, the second connecting tube 42 includes a third main tube 421 and a fifth branch tube 422 and a sixth branch tube 423 connected to the third main tube 421, the third main tube 421 is used to connect to the output end of the external therapeutic device A-adsorber, the fifth branch tube 422 is used to connect to the input connector of the blood return basic tube 12, and the sixth branch tube 423 is used to connect to the first external therapeutic device or the second external therapeutic device.

[0083] There are multiple auxiliary connecting tubes, which are used to connect two external therapeutic devices or connect the external therapeutic device with the basic tube. For example, there may be three auxiliary connecting tubes, namely the third connecting tube 43, the fourth connecting tube 44 and the fifth connecting tube 45. These connecting tubes are used to connect between the two external therapeutic devices, connect the two external therapeutic devices, and deliver the liquid output by the first external therapeutic device to the second external therapeutic device. The third connecting tube 43 is used to connect two external therapeutic devices A-adsorbers; the fourth connecting tube 44 is used to connect two external therapeutic devices B-dialyzers or connect the external therapeutic device C-plasma separator with the external therapeutic device B-dialyzer; the fifth connecting tube 45 is used to connect the external therapeutic device D-plasma component separator and the fourth liquid basic tube 34 (see the specific description in each mode below). Of course, in some practical applications, according to medical needs, the types of the above-mentioned external therapeutic devices A, B, C, and D can be replaced. In the description of each mode below in this article, specific therapeutic device types are used only to facilitate the understanding of the blood treatment mode.

[0084] By switching and combining the above-mentioned connecting tube and the fourth liquid medicine basic tube 34 and the fifth liquid medicine basic tube 35, and by regulating each pump, eleven treatment modes can be formed. The eleven treatment modes are: hemoperfusion, plasma exchange, double filtration plasma exchange, paired plasma filtration adsorption, plasma adsorption, double plasma molecular adsorption system, molecular adsorption recirculation system, plasma separation adsorption system, single-pass albumin dialysis, repeated albumin dialysis, plasma filtration dialysis.

[0085] The blood perfusion is as described above, and can be achieved by combining the blood base tube 10 with the perfusion device.

[0086] By starting the first liquid pump 1, the blood pump 4 and the waste liquid pump 5, using the blood basal tube 10, the waste liquid basal tube 20, the fourth drug liquid basal tube 34, combining with an external therapeutic device, and selecting whether the drug liquid bag and the waste liquid bag are connected and selecting the output position of the fourth drug liquid basal tube 34, liquid flow paths for three treatment modes of repeated albumin dialysis, single-pass albumin dialysis, and plasma exchange can be formed.

[0087] In the single-pass albumin dialysis and repeated albumin dialysis treatment modes, the external therapeutic device is a dialyzer, and the fourth drug solution basic tube 34 is connected to the dialyzer, and the drug solution is input into the dialyzer through the first liquid pump 1. The difference is that in the repeated albumin dialysis treatment mode, the waste liquid bag and the drug solution bag are connected, and the drug solution is reused; while in the single-pass albumin dialysis mode, the waste liquid bag and the drug solution bag are not connected.

[0088] In the plasma exchange treatment mode, the external treatment device is a plasma separator, and the fourth liquid medicine basic tube 34 is connected to the blood return basic tube 12; the first liquid pump 1, the blood pump 4 and the waste liquid pump 5 are started, and the blood flows into the plasma separator through the blood collection basic tube 11 through the pumping of the blood pump 4, and the plasma with pathogenic factors is separated and flows into the waste liquid bag through the waste liquid basic tube 20. The new plasma flows into the blood return basic tube 12 through the fourth liquid medicine basic tube 34 through the pumping of the first liquid pump 1, and is mixed with the blood after treatment and returned to the human body.

[0089] The plasma component separator is arranged on the blood basic tube 10, so that one end of the fifth medicine liquid basic tube 35 is connected to the medicine liquid bag and the other end is connected to the blood return basic tube 12; the first liquid pump 1, the second liquid pump 2, the blood pump 4 and the waste liquid pump 5 are started, and the liquid flow path of the plasma filtration dialysis mode can be formed through the combination of the external treatment device, the blood basic tube 10, the waste liquid basic tube 20, the fourth medicine liquid basic tube 34 and the fifth medicine liquid basic tube 35. In the plasma filtration dialysis mode, blood flows through the blood basic tube 10 through the external treatment device by the pumping of the blood pump 4, the medicine flows through the external treatment device through the fourth medicine liquid basic tube 34 by the pumping of the first liquid pump 1, and then flows into the waste liquid basic tube 20, and new plasma is replenished into the blood return basic tube 12 through the fifth medicine liquid basic tube 35 by the pumping of the second liquid pump 2.

[0090] A plasma separator and an adsorber are used. The plasma separator is connected between the blood collection basic tube 11 and the blood return basic tube 12. The adsorber is arranged between the first connecting tube 41 and the second connecting tube 42, that is, the input end and the output end of the adsorber are respectively connected to the first connecting tube 41 and the second connecting tube 42. In combination with the fifth liquid medicine basic tube 35, a plasma adsorption treatment mode can be formed. One end of the fifth liquid medicine basic tube 35 is connected to the output connector of the plasma separator, and the other end is connected to the first connecting tube 41. The second connecting tube 42 is connected to the input connector of the blood return basic tube 12. The second liquid pump 2 and the blood pump 4 are started. The blood is divided into two paths through the plasma separator. The first path flows into the blood return basic tube 12. The second path is separated and pumped by the second liquid pump 2 through the fifth liquid medicine basic tube 35 into the adsorber for adsorption purification, and then flows into the blood return basic tube 12 and merges with the first path.

[0091] Furthermore, another adsorber is added, and the two adsorbers are connected through a third connecting pipe 43, that is, the two ends are connected to the output of the first adsorber and the input of the second adsorber respectively. The remaining pipeline settings are the same as those of the plasma adsorption treatment mode, that is, the dual plasma molecule adsorption system treatment mode can be realized, such as Fig.11 shown.

[0092] By using a plasma separator, a dialyzer and an adsorber, through a blood pump 4, a waste liquid pump 5, a first liquid pump 1 and a second liquid pump 2, in combination with the fourth drug liquid basic tube 34, the fifth drug liquid basic tube 35, the second connecting tube 42 and the fourth connecting tube 44, and adjusting the number of adsorbers and the conductivity of the fifth branch tube 422 and the sixth branch tube 423, it is possible to form liquid flow paths for three treatment modes: paired plasma filtration adsorption, plasma separation adsorption system and molecular adsorption recycling.

[0093] Paired plasma filtration adsorption mode: the plasma separator is arranged between the blood collection basic tube 11 and the fourth connecting tube 44, the dialyzer is arranged between the fourth connecting tube 44 and the blood return basic tube 12, one end of the fifth liquid basic tube 35 is connected to the output end of the plasma separator, and the other end is connected to the first connecting tube 41 at the input end of the adsorber, the output end of the adsorber is the second connecting tube 42, the sixth branch 423 of the second connecting tube 42 is turned on and connected to the fourth connecting tube 44, and the fifth branch 422 is turned off. Start the first liquid pump, the second liquid pump 2, the blood pump 4 and the waste liquid pump 5. The blood is pumped by the blood pump 4 to flow through the plasma separator and is separated. The separated plasma is pumped by the second liquid pump 2 to flow through the fifth drug liquid basic tube 35, the adsorber, the second connecting tube 42 in sequence, and flows into the fourth connecting tube 44 through the second connecting tube 42, and mixes with the blood output by the plasma separator to flow into the dialyzer together; and the drug liquid is pumped by the first liquid pump 1 through the fourth drug liquid basic tube 34 into the dialyzer, and then flows to the waste liquid bag through the waste liquid basic tube 20.

[0094] Plasma separation adsorption system mode: Fig.13 As shown, the plasma separator is arranged between the blood collection basic tube 11 and the fourth connecting tube 44, the dialyzer is arranged between the fourth connecting tube 44 and the blood return basic tube 12, the fourth drug liquid basic tube 34 is connected to the dialyzer, the waste liquid basic tube 20 is also connected to the dialyzer, one end of the fifth drug liquid basic tube 35 is connected to the output connector of the separation side of the plasma separator, and the other end is connected to the first connecting tube 41 at the input end of the first adsorber, the first adsorber and the second adsorber are connected via the third connecting tube 43, the output end of the second adsorber is the second connecting tube 42, the sixth branch 423 of the second connecting tube 42 is connected and connected to the input connector of the plasma separator. The first liquid pump, the second liquid pump 2, the blood pump 4 and the waste liquid pump 5 are started, the plasma separated by the plasma separator is pumped by the second liquid pump 2 through the fifth drug liquid basic tube 35, flows through the two adsorbers in sequence, and then flows back to the plasma separator, and then flows into the dialyzer, and the dialysate also enters the dialyzer through the pumping of the first liquid pump 1.

[0095] Molecular adsorption recirculation system model MARS: Fig.14 As shown, the first dialyzer is arranged between the blood collection basic tube 11 and the blood return basic tube 12, the second dialyzer is arranged between the fourth liquid medicine basic tube 34 and the waste liquid basic tube 20, one end of the fifth liquid medicine basic tube 35 is connected to the output end of the dialysis side of the first dialyzer, and the other end is connected to the input end of the blood side of the second dialyzer, the first adsorber is connected to the output end of the blood side of the second dialyzer through the first connecting tube 41, and the second adsorber is connected to the input end of the dialysis side of the first dialyzer through the second connecting tube 42. The first liquid pump, the second liquid pump 2, the blood pump 4 and the waste liquid pump 5, the dialysate is pumped into the first dialyzer by the first liquid pump 1, the blood is separated by the first dialyzer through the pumping of the blood pump 4, the liquid dialyzed from the first dialyzer is pumped by the second liquid pump 2 through the fifth liquid medicine basic tube 35 into the second dialyzer, reacts with the dialysate, and after flowing out of the second dialyzer, flows through the two adsorbers in sequence and then flows back to the first dialyzer.

[0096] By using the plasma separator and the plasma component separator, in combination with the blood basal tube 10, the waste liquid basal tube 20, the fourth drug liquid basal tube 34, the fifth drug liquid basal tube 35 and the fifth connecting tube 45, a liquid flow path of a double filtration plasma exchange mode can be formed.

[0097] In the dual filtration plasma exchange mode, if Fig.15As shown, the plasma separator is connected between the blood collection basic tube 11 and the blood return basic tube 12, one end of the fifth medical liquid basic tube 35 is connected to the output end of the separation side of the plasma separator, and the other end is connected to the input end of the blood side of the plasma component separator, one end of the fifth connecting tube 45 is connected to the output end of the blood side of the plasma component separator, and the other end is connected to the fourth medical liquid basic tube 34, the fourth medical liquid basic tube 34 is connected to the blood return basic tube 12, and the waste liquid basic tube 20 is connected to the output end of the separation side of the plasma component separator. Start the first liquid pump, the second liquid pump 2, the blood pump 4 and the waste liquid pump 5. The blood enters the plasma component separator through the pumping of the blood pump 4. The plasma separated by the plasma separator enters the plasma component separator through the fifth medical liquid basic tube 35 for further separation through the pumping of the second liquid pump 2. The plasma in the plasma component separator after further separation flows back to the blood return basic tube 12 through the fifth connecting tube 45 and the fourth medical liquid basic tube 34 through the pumping of the first liquid pump 1, and the waste liquid output by the plasma component separator flows into the waste liquid bag through the waste liquid basic tube 20 through the pumping of the waste liquid pump 5.

[0098] To sum up the above, it can be seen that through the combination of the two liquid medicine pumps and the second sleeve in the present application, wherein the second sleeve includes two basic tubes and at least five connecting tubes, combined with the required external therapeutic devices, eleven blood treatment modes can be realized on the same device; through the pump group, pipeline valve combined with the first sleeve and the second sleeve, nineteen blood treatment modes can be realized on the same blood treatment device, and the number of configured pipelines is small, which is easy to use.

[0099] The basic principles of the present application are described above in conjunction with specific embodiments. However, it should be noted that the advantages, strengths, effects, etc. mentioned in the present application are only examples and not limitations, and it cannot be considered that these advantages, strengths, effects, etc. are required by each embodiment of the present application. In addition, the specific details disclosed above are only for the purpose of illustration and ease of understanding, not for limitation, and the above details do not limit the present application to being implemented by adopting the above specific details.

Claims

1. A blood treatment device, characterized in that: It comprises a device body (50) and an operation display screen (51), wherein the device body (50) is provided with a pump group, a pipeline valve and a controller; The pump group comprises a blood pump (4) for conveying blood to a blood path, a drug liquid pump for conveying drug liquid or plasma to a drug liquid path, and a waste liquid pump (5) for conveying waste liquid to a waste liquid path, and the drug liquid pump has a plurality of pumps and is used to convey drug liquid to a plurality of different drug liquid paths; The operation display screen (51) has an input module, through which instructions are transmitted to the controller so that the controller can regulate the operating status of each of the drug liquid pumps and the conduction status of the pipeline valves, and can transport drug liquid to different positions of the blood path through different drug liquid paths, so as to realize multiple treatment modes.

2. The blood treatment device according to claim 1, characterized in that The drug liquid pump comprises a first liquid pump (1), and the pipeline valve comprises a first valve (6), wherein the first valve (6) is used to switch between a first path and a second path; by adjusting the path conducted by the first valve (6) and the drug liquid path of the first liquid pump (1), three treatment modes can be formed.

3. The blood treatment device according to claim 2, characterized in that The three treatment modes are pre-hemofiltration dilution, post-hemofiltration dilution and hemodialysis. In the hemodialysis mode, the controller starts the first liquid pump (1) and causes the first valve (6) to conduct the first path, and the first liquid pump (1) is used to input liquid medicine to the external therapeutic device on the blood path through a liquid medicine path where the first path is located; In the pre-hemofiltration dilution mode, the controller starts the first liquid pump (1) and causes the first valve (6) to conduct the second path, and the first liquid pump (1) is used to transport liquid medicine to an upstream of an external therapeutic device on the blood path through a liquid medicine path where the second path is located; In the post-hemofiltration dilution mode, the controller starts the first liquid pump (1) and enables the first valve (6) to connect the second path, and the first liquid pump (1) is used to transport liquid medicine to the downstream of the external therapeutic device on the blood path through a liquid medicine path where the second path is located.

4. The blood treatment device according to claim 2, characterized in that The drug liquid pump further comprises a second liquid pump (2), and the pipeline valve further comprises a second valve (7), wherein the second valve (7) is used to conduct a third path and a fourth path; by adjusting the paths conducted by the first valve (6) and the second valve (7) and the drug liquid paths of the first liquid pump (1) and the second liquid pump (2), three other treatment modes can be formed.

5. The blood treatment device according to claim 4, characterized in that The other three treatment modes are hemofiltration mixed dilution, hemodiafiltration pre-dilution and hemodiafiltration post-dilution; In the blood filtration mixed dilution mode, the controller starts the first liquid pump (1) and the second liquid pump (2) and causes the first valve (6) to conduct the second path and the second valve (7) to conduct the fourth path; the first liquid pump (1) is used to deliver liquid medicine to the downstream of the external therapeutic device on the blood path through a liquid medicine path where the second path is located; and the second liquid pump (2) is used to deliver liquid medicine to the external therapeutic device on the blood path through a liquid medicine path where the fourth path is located; In the pre-hemodiafiltration dilution mode, the controller starts the first liquid pump (1) and the second liquid pump (2) and causes the first valve (6) to conduct the first path and the second valve (7) to conduct the fourth path, the first liquid pump (1) is used to deliver liquid medicine to the external therapeutic device through a liquid medicine path where the first path is located, and the second liquid pump (2) is used to deliver liquid medicine to the upstream of the external therapeutic device on the blood path through a liquid medicine path where the fourth path is located; In the pre-hemodiafiltration dilution mode, the controller starts the first liquid pump (1) and the second liquid pump (2) and causes the first valve (6) to conduct the first path and the second valve (7) to conduct the fourth path; the first liquid pump (1) is used to deliver liquid medicine to the external therapeutic device through a liquid medicine path where the first path is located; and the second liquid pump (2) is used to deliver liquid medicine to the downstream of the external therapeutic device on the blood path through a liquid medicine path where the fourth path is located.

6. The blood treatment device according to claim 4, characterized in that The liquid medicine pump further comprises a third liquid pump (3), which can form a liquid medicine path of a hemodiafiltration mixed dilution mode by starting the first liquid pump (1), the second liquid pump (2) and the third liquid pump (3) and connecting the first path and the fourth path; In this mode, the first liquid pump (1) is used to input liquid medicine into the external treatment device on the blood path, the second liquid pump (2) is used to input liquid medicine into the tube for returning blood connected to the downstream of the external treatment device, and the third liquid pump (3) is used to input liquid medicine into the tube for collecting blood connected to the upstream of the external treatment device.

7. A blood treatment system, characterized in that: It comprises the blood treatment device according to any one of claims 1 to 6, and an external consumable for connecting to the blood treatment device, the external consumable comprising an external pipe and an external treatment device, and the external consumable forms the blood path, the waste liquid path and the plurality of drug liquid paths.

8. The blood treatment system according to claim 7, characterized in that: The external pipe comprises a first sleeve, and the first sleeve comprises: A blood basic tube (10) which can be detachably arranged on the blood pump (4), comprising a blood collection basic tube (11) and a blood return basic tube (12) connected to the external therapeutic device; The first liquid medicine basic tube (31) can be detachably arranged on the first liquid pump (1), and is used to be connected to any one or any combination of the external treatment device, the blood collection basic tube (11), and the blood return basic tube (12) through the pipeline valve; A second medicine liquid basic tube (32) which can be detachably arranged on the second liquid pump (2), one end of which is used to be connected to the first medicine liquid basic tube (31) and the other end of which is used to be connected to the blood collection basic tube (11) and / or the blood return basic tube (12); A third basic medicine liquid tube (33) which can be detachably arranged on the third liquid pump (3), one end of which is used to be connected to the first basic medicine liquid tube (31) and the other end of which is used to be connected to the blood sampling basic tube (11); The waste liquid basic tube (20) can be detachably arranged on the waste liquid pump (5), one end of which is used to be connected to the output end of the external therapeutic device, and the other end of which is used to be connected to the waste liquid bag.

9. The blood treatment system according to claim 8, characterized in that: The first medicine liquid basic tube (31) comprises a first main tube (311) connected to the medicine liquid bag, and a first branch tube (312) and a second branch tube (313) connected to the first main tube (311), wherein the first branch tube (312) is connected to the external therapeutic device, and the second branch tube (313) is connected to the blood collection basic tube (11) or the blood return basic tube (12); The second medical liquid basic tube (32) comprises a second main tube (321) and a third branch tube (322) and a fourth branch tube (323) connected to the second main tube (321); the second main tube (321) is used to be connected to the first main tube (311); the third branch tube (322) is connected to the second branch tube (313) so as to be connected to the blood collection basic tube (11) through the second branch tube (313); the fourth branch tube (323) is used to be connected to the blood collection basic tube (11) or the blood return basic tube (12).

10. The blood treatment system according to claim 7 or 8, characterized in that: The external pipe includes a second sleeve, and the second sleeve includes: A blood base tube (10) and a waste liquid base tube (20); a fourth medicine liquid basic tube (34) which can be detachably arranged on the first liquid pump (1), one end of which is connected to the medicine liquid bag and the other end of which is used to be connected to the external treatment device or the blood return basic tube (12) of the blood basic tube; a fifth liquid medicine basic tube (35) which can be detachably arranged on the second liquid pump (2) and is used to be connected to the blood return basic tube (12), or to be connected between the two external therapeutic devices; A first connecting tube (41), connected to the input end of the external therapeutic device A, and used to connect the external therapeutic device A to other external therapeutic devices or a basic tube; A second connecting pipe (42), connected to the output end of the external therapeutic device A, comprising a third main pipe (421) and a fifth branch pipe (422) and a sixth branch pipe (423) both connected to the third main pipe (421) via the pipeline valve; A plurality of auxiliary connecting pipes are provided.

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