Anti-adhesion wet dressing for promoting healing of burn wound and preparation method of anti-adhesion wet dressing

Abstract

The invention relates to the technical field of medical surgical article materials, and discloses an anti-adhesion wet dressing for promoting burn wound healing, the dressing comprises: a bottom layer made of a polypropylene non-woven fabric; the composite hydrogel layer covers the bottom layer and is formed by a colloidal solution prepared by mixing the following components. Compared with the prior art, the anti-adhesion wet dressing for promoting healing of the burn wound has the advantages that the anti-adhesion wet dressing has good anti-adhesion performance, and damage to the wound when the dressing is replaced can be effectively reduced; the composite hydrogel layer can self-adjust the moist environment of the wound, and healing of the burn wound is facilitated; chitosan is used as an anti-adhesion component and can be released in the process of being attached to the wound, so that the anti-adhesion effect is further improved; the preparation method is simple, free of organic solvent residues and suitable for large-scale production.

Description

Technical Field

[0001] The invention relates to the technical field of medical surgical supplies materials, and in particular to an anti-adhesion wet dressing for promoting the healing of burn wounds and a preparation method thereof. Background Art

[0002] In the healing process of burn wounds, anti-adhesion and maintaining a moist environment are of great significance for promoting wound healing. Existing burn and scald dressings have the problems of easy adhesion, poor strength, poor water absorption, and easy wound infection. Therefore, the development of a wet dressing with anti-adhesion function, self-regulating wound moisture environment and antibacterial has important practical value for the healing of burn wounds. Summary of the invention

[0003] The purpose of the present invention is to solve the shortcomings of the prior art and to propose an anti-adhesion moist dressing for promoting the healing of burn wounds and a preparation method thereof.

[0004] In order to achieve the above object, the present invention adopts the following technical solutions:

[0005] An anti-adhesion moist dressing for promoting the healing of burn wounds, the dressing comprising:

[0006] The bottom layer is made of polypropylene nonwoven fabric;

[0007] The composite hydrogel layer, covering the bottom layer, is formed by a colloidal solution prepared by mixing the following components: sodium carboxymethyl cellulose, as the main skeleton component of the hydrogel; sodium alginate, as the thickener and humectant of the hydrogel; chitosan, as an anti-adhesion component, which is dissolved in the hydrogel matrix through high-intensity mechanical stirring and released when attached to the wound; propylene glycol, as a humectant and antibacterial agent, to regulate the moist environment of the hydrogel.

[0008] As a further description of the above technical solution:

[0009] The mass ratio of sodium carboxymethyl cellulose, sodium alginate, chitosan and propylene glycol in the composite hydrogel layer ranges from 5:2:1:1 to 15:8:3:5, and the specific ratio can be adjusted according to the specific needs of the burn wound.

[0010] As a further description of the above technical solution:

[0011] The polypropylene nonwoven fabric is washed, dried and sterilized before being coated with the composite hydrogel layer to ensure that it is clean and sterile.

[0012] As a further description of the above technical solution:

[0013] The polypropylene nonwoven fabric is pretreated, including washing, drying and disinfecting;

[0014] Sodium carboxymethyl cellulose, sodium alginate, chitosan and propylene glycol are mixed, water is added, and a uniform colloidal solution is formed by high-intensity mechanical stirring;

[0015] The prepared colloidal solution is evenly coated on the pretreated polypropylene non-woven fabric to form a composite hydrogel layer;

[0016] The polypropylene nonwoven fabric coated with the composite hydrogel layer is dried until the water content in the composite hydrogel layer reaches a predetermined content, thereby forming a final anti-adhesion wet dressing.

[0017] As a further description of the above technical solution:

[0018] The drying process is performed at a temperature of 40° C. to 80° C. and a humidity of 20% to 60% for a duration of 1 to 4 hours.

[0019] As a further description of the above technical solution:

[0020] Prior to coating the composite hydrogel layer, multiple layers of functional coatings, such as antibacterial coatings, hemostatic coatings, or growth factor coatings, are coated on the polypropylene nonwoven fabric.

[0021] The present invention has the following beneficial effects:

[0022] The anti-adhesion moist dressing for promoting burn wound healing provided by the present invention has good anti-adhesion performance and can effectively reduce the damage to the wound when changing the dressing; the composite hydrogel layer can self-regulate the moist environment of the wound, which is beneficial to the healing of the burn wound; chitosan, as an anti-adhesion component, is released during the process of attaching to the wound, further improving the anti-adhesion effect; the preparation method of the present invention is simple, has no organic solvent residue, and is suitable for large-scale production. DETAILED DESCRIPTION

[0023] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0024] An embodiment provided by the present invention:

[0025] An anti-adhesion moist dressing for promoting the healing of burn wounds, the dressing comprising:

[0026] The bottom layer is made of polypropylene non-woven fabric, which has sufficient strength and breathability;

[0027] The composite hydrogel layer is covered on the bottom layer and is formed by a colloidal solution prepared by mixing the following components: sodium carboxymethyl cellulose, as the main skeleton component of the hydrogel; sodium alginate, as the thickener and moisturizer of the hydrogel; chitosan, as an anti-adhesion component, which is dissolved in the hydrogel matrix through high-intensity mechanical stirring and released when attached to the wound; propylene glycol, as a moisturizer and antibacterial agent, to adjust the moist environment of the hydrogel;

[0028] The mass ratio of sodium carboxymethyl cellulose, sodium alginate, chitosan and propylene glycol in the composite hydrogel layer ranges from 5:2:1:1 to 15:8:3:5, and the specific ratio can be adjusted according to the specific needs of the burn wound surface;

[0029] Before coating the composite hydrogel layer, the polypropylene non-woven fabric is washed, dried and sterilized to ensure that it is clean and sterile; the polypropylene non-woven fabric is pretreated, including washing, drying and sterilizing; sodium carboxymethyl cellulose, sodium alginate, chitosan and propylene glycol are mixed, water is added, and a uniform colloidal solution is formed by high-intensity mechanical stirring; the prepared colloidal solution is uniformly coated on the pre-treated polypropylene non-woven fabric to form a composite hydrogel layer; the polypropylene non-woven fabric coated with the composite hydrogel layer is dried until the water content in the composite hydrogel layer reaches a predetermined content to form a final anti-adhesion wet dressing;

[0030] The drying process is carried out at a temperature of 40° C. to 80° C. and a humidity of 20% to 60% for a duration of 1 to 4 hours, wherein the specific conditions are adjusted according to the drying speed and expected performance of the composite hydrogel layer;

[0031] Prior to coating the composite hydrogel layer, multiple functional coatings, such as antibacterial coating, hemostatic coating, or growth factor coating, are coated on the polypropylene nonwoven fabric to further enhance the performance of the dressing.

[0032] Working principle: The present invention provides an innovative anti-adhesion wet dressing for promoting burn wound healing and a preparation method thereof. The dressing uses polypropylene non-woven fabric as the bottom layer, combined with a composite hydrogel layer prepared from sodium carboxymethyl cellulose, sodium alginate, chitosan and propylene glycol, to achieve excellent anti-adhesion performance, self-adjusting moist environment ability and antibacterial function; high-intensity mechanical stirring is used to ensure that chitosan is fully dissolved in the hydrogel matrix, significantly improving the anti-adhesion effect of the dressing; in addition, by adjusting the proportion of each component in the composite hydrogel layer, the performance of the dressing can be further optimized to meet the specific needs of different burn wound healing.

[0033] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. An anti-adhesion moist dressing for promoting burn wound healing, characterized in that: The dressing comprises: a base layer made of polypropylene nonwoven fabric; The composite hydrogel layer, covering the bottom layer, is formed by a colloidal solution prepared by mixing the following components: sodium carboxymethyl cellulose, as the main skeleton component of the hydrogel; sodium alginate, as the thickener and humectant of the hydrogel; chitosan, as an anti-adhesion component, which is dissolved in the hydrogel matrix through high-intensity mechanical stirring and released when attached to the wound; propylene glycol, as a humectant and antibacterial agent, to regulate the moist environment of the hydrogel.

2. The anti-adhesion moist dressing for promoting burn wound healing and the preparation method thereof according to claim 1, characterized in that: The mass ratio of sodium carboxymethyl cellulose, sodium alginate, chitosan and propylene glycol in the composite hydrogel layer ranges from 5:2:1:1 to 15:8:3:5, and the specific ratio can be adjusted according to the specific needs of the burn wound.

3. The anti-adhesion moist dressing for promoting burn wound healing and the preparation method thereof according to claim 1, characterized in that: The polypropylene nonwoven fabric is washed, dried and sterilized before being coated with the composite hydrogel layer to ensure that it is clean and sterile.

4. A method for preparing the anti-adhesion moist dressing for promoting burn wound healing according to any one of claims 1 to 3, characterized in that: The method comprises the following steps: The polypropylene nonwoven fabric is pretreated, including washing, drying and disinfecting; Sodium carboxymethyl cellulose, sodium alginate, chitosan and propylene glycol are mixed, water is added, and a uniform colloidal solution is formed by high-intensity mechanical stirring; The prepared colloidal solution is evenly coated on the pretreated polypropylene non-woven fabric to form a composite hydrogel layer; The polypropylene nonwoven fabric coated with the composite hydrogel layer is dried until the water content in the composite hydrogel layer reaches a predetermined content, thereby forming a final anti-adhesion wet dressing.

5. The preparation method according to claim 4, characterized in that: The drying process is performed under the conditions of a temperature of 40° C. to 80° C. and a humidity of 20% to 60% for a duration of 1 to 4 hours.

6. The preparation method according to claim 4 or 5, characterized in that: Prior to coating the composite hydrogel layer, multiple layers of functional coatings, such as antibacterial coatings, hemostatic coatings, or growth factor coatings, are coated on the polypropylene nonwoven fabric.