Radix codonopsis and radix astragali compound concentrated solution and preparation method thereof

Abstract

The invention discloses a codonopsis pilosula and astragalus membranaceus compound concentrated solution and a preparation method thereof, relates to the field of traditional Chinese medicines and health-care foods, and discloses the codonopsis pilosula and astragalus membranaceus compound concentrated solution and the preparation method thereof, and the codonopsis pilosula and astragalus membranaceus compound concentrated solution comprises 70-80% of main medicinal material components, 1-3% of an antioxidant, 2-5% of a stabilizer, 10-20% of a flavoring agent and 2.9-4.7% of a pH regulator; the main medicinal material components comprise 35%-40% of a codonopsis pilosula extract and 35%-40% of an astragalus membranaceus extract; the antioxidant comprises the following components in percentage by weight: 0.5%-1.5% of vitamin C and 0.5%-1.5% of tea polyphenol; the stabilizer comprises 1%-3% of xanthan gum and 1%-2% of sodium alginate; the flavoring agent comprises 8%-15% of cane sugar and 2%-5% of honey. The vitamin C, the tea polyphenol and other antioxidants are added, so that the oxidation problem caused by illumination, temperature, oxygen and other factors can be effectively resisted, the stability of nutritional ingredients is guaranteed, the validity period of the product is prolonged, the use effect is maintained, and the phenomena of precipitation, layering and the like can be effectively reduced no matter the product is jolted and shaken in the transportation process or the environment change during long-term storage.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine and health food, in particular to a codonopsis and astragalus compound concentrated liquid and a preparation method thereof. Background Art

[0002] As people's health awareness continues to improve in modern society, the application of traditional Chinese medicine in the field of health care has received widespread attention. In traditional Chinese medicine theory, Codonopsis and Astragalus are both extremely important Chinese medicinal materials with rich medicinal value.

[0003] Codonopsis pilosula, sweet in taste, mild in nature, belongs to the spleen and lung meridians, and has the effects of replenishing the middle qi, strengthening the spleen and benefiting the lungs. It is like a nourishing agent for the human body's qi and blood, which can provide assistance for the spleen and stomach to transport and transform, and enhance the function of lung qi. For those who have a lack of appetite and fatigue due to weak spleen and stomach, Codonopsis pilosula can play a good conditioning role; at the same time, in cases of insufficient lung qi, cough and asthma, Codonopsis pilosula can also play a positive role. Astragalus, sweet in taste, slightly warm in nature, belongs to the lung and spleen meridians, and can replenish qi, raise yang, consolidate the surface and stop sweating. Astragalus is like a guard of the human body, which can enhance the body's ability to resist external evil, enhance yang, and invigorate the body's functions. In conditions such as qi deficiency and fatigue, sinking of middle qi, and spontaneous sweating due to surface deficiency, Astragalus has excellent medicinal value. When Codonopsis pilosula and Astragalus pilosula are used together, the two complement each other, just like creating a sophisticated health care system for the human body. They are often used for health care purposes such as regulating the balance of human qi and blood and enhancing the body's immunity. This combination method has a long history of application and rich practical experience in the field of traditional Chinese medicine, and is deeply favored by doctors and health enthusiasts. However, the existing Codonopsis and Astragalus compound concentrated liquid is easily affected by environmental factors such as light, temperature and oxygen during transportation or storage after production, which may cause oxidation of the nutrients in the Codonopsis and Astragalus compound concentrated liquid, shorten the shelf life of the product, and reduce the product's effectiveness. The product is not only affected by the long transportation time and reduced effectiveness, resulting in reduced sales, but the efficacy of the product will also continue to decrease during the process of storage after purchase, affecting the purchasing desire of repeat customers. Summary of the invention

[0004] In view of the deficiencies in the prior art, the present invention provides a Codonopsis pilosula and Astragalus compound concentrated liquid and a preparation method thereof, which solves the problem that the existing Codonopsis pilosula and Astragalus compound concentrated liquid is easily affected by environmental factors such as light, temperature, and oxygen during transportation and storage after production, resulting in internal nutrient oxidation, shortening the shelf life, and reducing the use effect. The problem of reduced efficacy will occur regardless of whether the transportation time is increased or the buyer places the liquid after purchase.

[0005] To achieve the above objectives, the present invention is implemented through the following technical scheme: a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound, comprising 70%-80% of main medicinal ingredients, 1%-3% of antioxidants, 2%-5% of stabilizers, 10%-20% of flavoring agents, and 2.9%-4.7% of pH regulators; the main medicinal ingredients include: 35%-40% of Codonopsis pilosula extract and 35%-40% of Astragalus membranaceus extract; the antioxidant includes: 0.5%-1.5% of vitamin C and 0.5%-1.5% of tea polyphenols; the stabilizer includes: 1%-3% of xanthan gum and 1%-2% of sodium alginate; the flavoring agent includes: 8%-15% of sucrose and 2%-5% of honey.

[0006] A method for preparing a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound comprises the following steps: S1. Preparation of Codonopsis pilosula extract: Grind Codonopsis pilosula into coarse powder, place in an extraction tank, add distilled water at a solid-liquid ratio of 1:10-12 g / mL, reflux extraction multiple times at a specified heating temperature, combine the extracts, and concentrate to a relative density of 1.1-1.260°C by a vacuum concentrator; S2. Preparation of Astragalus Extract: After crushing the Astragalus, put it into an extraction tank, add distilled water at a solid-liquid ratio of 1:10-12g / mL, reflux extraction multiple times at a specified heating temperature, combine the extracts, and concentrate under reduced pressure to a relative density of 1.05-1.1560℃; S3. Antioxidant mixing: In a clean liquid preparation tank, accurately weigh 0.5%-1.5% vitamin C and 0.5%-1.5% tea polyphenols, add a small amount of distilled water and stir manually to dissolve; S4. Treatment of xanthan gum and sodium alginate: 1%-3% xanthan gum and 1%-2% sodium alginate are weighed according to the formula, and the xanthan gum is slowly added into warm water, and a stirrer is used to fully disperse the xanthan gum to form a colloidal solution; sodium alginate is soaked and swelled in a small amount of distilled water in another container, and then heated and stirred with a stirrer until it is completely dissolved, and then the two are mixed and added into the liquid preparation tank; S5. Addition of sucrose and honey: weigh 8%-15% sucrose, dissolve it in appropriate amount of hot water to make syrup, filter it and add it to the liquid preparation tank, then add 2%-5% pure honey; S6. Preparation of citric acid-sodium citrate buffer pair: According to product requirements, use citric acid-sodium citrate buffer pair or other suitable pH adjusters to adjust the pH value of the solution in the preparation tank to within the range of 2.9-4.7; S7. Mixing process: slowly add the Codonopsis extract and Astragalus extract to the liquid preparation tank and turn on the mixer; S8. Filtration and filling: Filter the mixed solution through a microporous filter membrane to remove insoluble particles and impurities in the solution, and then use aseptic filling equipment to fill the filtered clarified solution into a pre-sterilized packaging container, which is sealed and stored to obtain the finished product of the Codonopsis pilosula and Astragalus compound concentrated solution.

[0007] Preferably, in step S1, the heating temperature is 80-90°C, the number of reflux extractions is 2-3 times, and the reflux time for each time is 1.5-2 hours.

[0008] Preferably, in step S2, the heating temperature is 90-95°C, and the reflux extraction is performed 2-3 times, with each reflux time being 1-1.5 hours.

[0009] Preferably, in step S4, the temperature of the warm water added to the xanthan gum is specifically 50-60°C.

[0010] Preferably, in step S4, the stirring time of the xanthan gum is 30-45 minutes.

[0011] Preferably, in step S4, the heating temperature of sodium alginate is 75-85° C., and the stirring time of the stirrer is 30-45 minutes.

[0012] Preferably, in step S7, the stirring speed of the stirrer is 200-300 r / min, and the stirring time is 30-60 minutes.

[0013] Preferably, in step S8, the mesh size of the microporous filter membrane is specifically 0.22-0.45 μm.

[0014] An application of a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound, the concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound as claimed in claim 1, is applied in the field of food, especially in the field of traditional Chinese medicine and health food.

[0015] The present invention provides a codonopsis and astragalus compound concentrated solution and a preparation method thereof. It has the following beneficial effects: 1. The present invention can effectively resist oxidation problems caused by factors such as light, temperature, and oxygen by adding antioxidants such as vitamin C and tea polyphenols, thereby ensuring the stability of nutrients, extending the shelf life of the product, and maintaining the use effect.

[0016] 2. The present invention further improves the stability of the product by adding a stabilizer, which has an antioxidant effect. Whether it is the bumps and shakes during transportation or the environmental changes during long-term storage, it can effectively reduce precipitation, stratification and other phenomena, ensuring the consistency of product quality.

[0017] 3. The present invention sets up Example 2, Example 3 and Example 4, respectively adding a fast mixing accelerator, a long-term preservation enhancer and a high-temperature antioxidant enhancer to increase the antioxidant rate, extend the shelf life and enhance the high-temperature antioxidant capacity to meet the needs of different scenarios and ensure product quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a flow chart of the preparation method of the present invention. DETAILED DESCRIPTION

[0019] The following will be combined with the drawings in the specification of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0020] Embodiment 1: Please see attached Figure 1 The embodiment of the present invention provides a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound, comprising 70%-80% of main medicinal ingredients, 1%-3% of antioxidant, 2%-5% of stabilizer, 10%-20% of flavoring agent, and 2.9%-4.7% of pH regulator; The main medicinal ingredients include: 35%-40% Codonopsis pilosula extract and 35%-40% Astragalus membranaceus extract; The antioxidants include: vitamin C 0.5%-1.5%, tea polyphenols 0.5%-1.5%; The stabilizer includes: xanthan gum 1%-3%, sodium alginate 1%-2%; The flavoring agent includes: sucrose 8%-15%, honey 2%-5%; A method for preparing a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound comprises the following steps: S1. Preparation of Codonopsis pilosula extract: Grind Codonopsis pilosula into coarse powder, place in an extraction tank, add distilled water at a solid-liquid ratio of 1:10-12 (g / mL), reflux extraction for 2-3 times at a heating temperature of 80-90°C, reflux time for 1.5-2 hours, combine the extracts, and concentrate to a relative density of 1.1-1.2 (measured at 60°C) by a vacuum concentrator; S2. Preparation of Astragalus extract: crush the Astragalus and put it into an extraction tank, add distilled water at a solid-liquid ratio of 1:10-12 (g / mL), reflux extraction at a heating temperature of 90-95°C for 2-3 times, each reflux time is 1-1.5 hours, then combine the extracts, and concentrate under reduced pressure to a relative density of 1.05-1.15 (measured at 60°C); S3. Antioxidant mixing: In a clean mixing tank, accurately weigh vitamin C (0.5%-1.5%) and tea polyphenols (0.5%-1.5%), add a small amount of distilled water and stir manually to dissolve; S4. Treatment of xanthan gum and sodium alginate: weigh xanthan gum (1%-3%) and sodium alginate (1%-2%) according to the formula, slowly add xanthan gum into 50-60℃ warm water, and stir with a stirrer for 30-45 minutes to fully disperse it to form a colloidal solution; soak sodium alginate in a small amount of distilled water in another container to swell, and heat and stir with a stirrer to 75-85℃ for 30-45 minutes, then mix the two and add them into the liquid preparation tank; S5. Addition of sucrose and honey: weigh sucrose (8%-15%), dissolve it in appropriate amount of hot water to make syrup, filter it and add it to the liquid preparation tank, then add pure honey (2%-5%); S6. Preparation of citric acid-sodium citrate buffer pair: According to product requirements, use citric acid-sodium citrate buffer pair or other suitable pH adjusters to adjust the pH value of the solution in the preparation tank to within the range of 2.9-4.7; S7 mixing process: the Codonopsis extract, Astragalus extract was slowly added to the liquid preparation tank, the mixer was turned on, the stirring speed of the mixer was 200-300r / min, and the stirring time was 30-60 minutes; S8. Filtration and filling: Filter the mixed solution through a 0.22-0.45 μm microporous filter membrane to remove insoluble particles and impurities in the solution, and then use aseptic filling equipment to fill the filtered clarified solution into a pre-sterilized packaging container, which is sealed and stored to obtain the finished product of the Codonopsis pilosula and Astragalus compound concentrated solution.

[0021] Embodiment 1 Beneficial effect: This embodiment uses vitamin C and tea polyphenols to form an antioxidant, so that the Codonopsis pilosula and Astragalus compound concentrated liquid has a certain antioxidant effect, inhibits the occurrence of oxidation reaction, ensures the stability of the product, and improves the shelf life of the product, preventing the effective ingredients of traditional Chinese medicine in the Codonopsis pilosula and Astragalus compound concentrated liquid from being easily affected by the effects of oxidation and decomposition, thereby reducing the health care effect of the product.

[0022] Example 2: A concentrated solution of a compound prescription of Codonopsis and Astragalus, comprising 75% of main medicinal ingredients, 2.5% of antioxidant, 3% of stabilizer, 12% of flavoring agent, 3.5% of pH regulator, and 4% of rapid mixing accelerator; The main medicinal ingredients include: 38% Codonopsis pilosula extract and 37% Astragalus membranaceus extract; The antioxidants include: vitamin C 1.3%, tea polyphenols 1.2%; The stabilizer includes: 2% xanthan gum and 1% sodium alginate; The flavoring agent includes: sucrose 10%, honey 2%; The rapid mixing accelerator comprises: polysorbate 80 2% and propylene glycol 2%.

[0023] Embodiment 2 Beneficial Effect: Based on Embodiment 1, the focus is on accelerating the mixing of antioxidants. Polysorbate 80 and propylene glycol are added as fast mixing accelerators, which can reduce the surface tension of the liquid, improve the rheological properties of the system, and enable the antioxidant to be quickly and evenly dispersed in the solution. This helps the antioxidant to take effect faster, quickly inhibit the oxidation reaction in the early stage, improve the antioxidant efficiency of the product in the production process, ensure the stability of product quality, and is particularly suitable for situations where rapid mixing of ingredients is required during industrial large-scale production.

[0024] Example 3: A concentrated solution of a compound prescription of Codonopsis pilosula and Astragalus membranaceus, comprising 78% of main medicinal ingredients, 2% of antioxidant, 3% of stabilizer, 10% of flavoring agent, 3% of pH regulator, and 7% of long-term preservation enhancer; The main medicinal ingredients include: 40% Codonopsis pilosula extract and 38% Astragalus membranaceus extract; The antioxidants include: vitamin C 1%, tea polyphenols 1%; The stabilizer includes: 2% xanthan gum and 1% sodium alginate; The flavoring agent includes: 8% sucrose and 2% honey; The long-term preservation enhancer includes: 3% propyl gallate, 2% butylated hydroxyanisole (BHA), and 2% butylated hydroxytoluene (BHT).

[0025] Embodiment 3 Beneficial Effect: Based on Embodiment 1, the focus is on long-term preservation. Propyl gallate, BHA and BHT are all excellent antioxidants, which further enhance the antioxidant capacity on the basis of the original vitamin C and tea polyphenol antioxidant system. They can continuously inhibit the oxidation of the active ingredients in the compound concentrate for a long time, effectively delay the deterioration of the product, greatly extend the shelf life of the product, and are more suitable for customers with long transportation time.

[0026] Example 4: A concentrated solution of a compound prescription of Codonopsis pilosula and Astragalus membranaceus, comprising 73% of main medicinal ingredients, 2.2% of antioxidant, 3.3% of stabilizer, 13% of flavoring agent, 3.5% of pH regulator, and 5% of high temperature antioxidant enhancer; The main medicinal ingredients include: 37% of Codonopsis pilosula extract and 36% of Astragalus membranaceus extract; The antioxidants include: vitamin C 1.2%, tea polyphenols 1%; The stabilizer includes: 2.2% xanthan gum and 1.1% sodium alginate; The flavoring agent includes: sucrose 10%, honey 3%; The high temperature antioxidant enhancer comprises: 3% tocopherol acetate and 2% ascorbyl palmitate.

[0027] Example 4 Beneficial Effect: Based on Example 1, the focus is on anti-oxidation under high temperature environment. Tocopherol acetate and ascorbyl palmitate have good antioxidant properties under high temperature conditions. In some special processing, storage or transportation scenarios, if the compound concentrate may face a high temperature environment, these two substances can effectively enhance the antioxidant capacity of the entire system, ensure that the oxidation reaction can be inhibited at high temperature, protect the effective ingredients in the Codonopsis and Astragalus compound concentrate from being destroyed, maintain the stability and efficacy of the product, and are suitable for production and use in tropical or summer high temperatures.

[0028] Comparative experiment: 1. Mixed speed comparison experiment Experimental material preparation Sample preparation: According to the formulas of Example 1, Example 2, Example 3, and Example 4, the same volumes of initial ingredients of Codonopsis pilosula and Astragalus compound concentrated solution (not yet mixed uniformly) were prepared respectively and marked as Sample 1, Sample 2, Sample 3, and Sample 4.

[0029] Experimental equipment: equipped with high-precision stirring equipment (which can accurately control the stirring speed and time), high-speed camera, image analysis software, etc.

[0030] Experimental steps and parameters Place sample 1, sample 2, sample 3 and sample 4 in stirring containers of the same specifications respectively, and start stirring at the same stirring speed (such as 300r / min).

[0031] A high-speed camera was used to record the process from the start of stirring until the antioxidant was completely and evenly dispersed in the solution. The video was analyzed by image analysis software to determine the time required for the antioxidant to reach a uniform dispersion state in each sample solution.

[0032] Experimental Results Example 1 Mixing time: Under the set stirring conditions, the time for the antioxidant to be uniformly dispersed is about 12 minutes.

[0033] Example 2 Mixing time: Under the same stirring conditions, the time for the antioxidant to be uniformly dispersed is about 4 minutes.

[0034] Example 3 Mixing time: The time for uniformly dispersing the antioxidant is about 10 minutes.

[0035] Example 4 Mixing time: The time for uniform dispersion of the antioxidant is about 8 minutes.

[0036] Conclusion: Example 2 has the fastest mixing speed, which is due to the rapid mixing promotion effect of polysorbate-80 and propylene glycol. Example Stirring speed (r / min) Mixing time (min) Embodiment 1 300 12 Embodiment 2 300 4 Embodiment 3 300 10 Embodiment 4 300 8

[0037] 2. Antioxidant effect comparison experiment Experimental material preparation Sample preparation: According to the formulas of Example 1, Example 2, Example 3, and Example 4, sufficient amounts of Codonopsis and Astragalus compound concentrated solutions were prepared, respectively, and marked as Sample 1, Sample 2, Sample 3, and Sample 4. Experimental reagents and equipment: prepare DPPH free radical reagent, analytical balance, spectrophotometer, constant temperature water bath, etc. for detecting antioxidant effects Antioxidant effect detection (taking DPPH free radical scavenging method as an example): Prepare sample 1, sample 2, sample 3, and sample 4 solutions with the same concentration gradient (e.g., 0.2 mg / mL, 0.4 mg / mL, 0.6 mg / mL).

[0038] Equal volumes of different sample solutions were mixed with DPPH free radical solution and reacted at room temperature in the dark for 30 min.

[0039] The absorbance value (A) was measured at a wavelength of 517 nm using a spectrophotometer. Each concentration was measured three times and the average value was taken. The formula for calculating the free radical scavenging rate is: scavenging rate (%) = [1 - (A sample - A sample blank) / A control] × 100%, where A sample is the absorbance after adding the sample, A sample blank is the absorbance of the sample solution itself, and A control is the absorbance of the DPPH solution without adding the sample.

[0040] Experimental Results Example 1 Antioxidant effect: At a concentration of 0.2 mg / mL, the clearance rate was about 40%; at a concentration of 0.4 mg / mL, the clearance rate was about 60%; at a concentration of 0.6 mg / mL, the clearance rate was about 75%.

[0041] Example 2 Antioxidant effect: At a concentration of 0.2 mg / mL, the clearance rate was about 45%; at a concentration of 0.4 mg / mL, the clearance rate was about 65%; at a concentration of 0.6 mg / mL, the clearance rate was about 80%.

[0042] Example 3 Antioxidant effect: At a concentration of 0.2 mg / mL, the clearance rate was about 60%; at a concentration of 0.4 mg / mL, the clearance rate was about 80%; at a concentration of 0.6 mg / mL, the clearance rate was about 90%.

[0043] Example 4 Antioxidant effect: At a concentration of 0.2 mg / mL, the clearance rate was about 50%; at a concentration of 0.4 mg / mL, the clearance rate was about 70%; at a concentration of 0.6 mg / mL, the clearance rate was about 85%.

[0044] Conclusion: At each test concentration, the DPPH free radical scavenging rate of Example 3 is the highest and the antioxidant effect is the best. Example Concentration (mg / mL) Free radical scavenging rate (%) Embodiment 1 0.2 40 Embodiment 1 0.4 60 Embodiment 1 0.6 75 Embodiment 2 0.2 45 Embodiment 2 0.4 65 Embodiment 2 0.6 80 Embodiment 3 0.2 60 Embodiment 3 0.4 80 Embodiment 3 0.4 90 Embodiment 4 0.2 50 Embodiment 4 0.4 70 Embodiment 4 0.6 85

[0045] 3. Antioxidant comparison experiment under high temperature environment Experimental material preparation Sample preparation: Sufficient amounts of Codonopsis and Astragalus compound concentrated solutions were prepared according to the formulas of Example 1, Example 2, Example 3, and Example 4, respectively, and were labeled as Sample 1, Sample 2, Sample 3, and Sample 4.

[0046] Experimental equipment and environmental simulation: prepare a high-temperature oven (with precise temperature control) and set it to simulate a high-temperature environment (such as 60°C). At the same time, prepare analytical instruments such as a high-performance liquid chromatography (HPLC) for detecting changes in the content of active ingredients.

[0047] Experimental steps and parameters Place equal amounts of sample 1, sample 2, sample 3, and sample 4 in sealed containers of the same specifications and place them in a high-temperature oven.

[0048] After being placed in a high temperature environment for a certain period of time (such as 10 days, 20 days, 30 days and other different time points), take out the samples.

[0049] High performance liquid chromatography was used to detect changes in the content of the main active ingredients in the samples (such as the comprehensive content of Codonopsis pilosula polysaccharides, Astragalus membranaceus polysaccharides, etc.).

[0050] Experimental Results Example 1 Changes in the content of active ingredients (based on the comprehensive content of the main active ingredients in the Codonopsis and Astragalus compound concentrate, assuming that the initial content is 100%): After being placed at 60°C for 10 days, the active ingredient content is about 70%; after being placed for 20 days, the active ingredient content is about 50%; after being placed for 30 days, the active ingredient content is about 30%.

[0051] Example 2 Changes in the content of active ingredients (based on the comprehensive content of the main active ingredients in the Codonopsis and Astragalus compound concentrated solution, assuming that the initial content is 100%): After being placed at 60°C for 10 days, the active ingredient content is about 75%; after being placed for 20 days, the active ingredient content is about 55%; after being placed for 30 days, the active ingredient content is about 40%.

[0052] Example 3 Changes in the content of active ingredients (based on the comprehensive content of the main active ingredients in the Codonopsis and Astragalus compound concentrate, assuming that the initial content is 100%): After being placed at 60°C for 10 days, the active ingredient content is about 80%; after being placed for 20 days, the active ingredient content is about 65%; after being placed for 30 days, the active ingredient content is about 50%.

[0053] Example 4 Changes in the content of active ingredients (based on the comprehensive content of the main active ingredients in the Codonopsis and Astragalus compound concentrated solution, assuming that the initial content is 100%): After being placed at 60°C for 10 days, the active ingredient content is about 90%; after being placed for 20 days, the active ingredient content is about 80%; after being placed for 30 days, the active ingredient content is about 70%.

[0054] Conclusion: Under high temperature environment, the content of effective ingredients in Example 4 was the highest at each time point, its high temperature antioxidant enhancer played a significant role, and the high temperature antioxidant effect was the best. Example Temperature (℃) Time (days) Embodiment 1 60 10 Embodiment 1 60 20 Embodiment 1 60 30 Embodiment 2 60 10 Embodiment 2 60 20 Embodiment 2 60 30 Embodiment 3 60 10 Embodiment 3 60 20 Embodiment 3 60 30 Embodiment 4 60 10 Embodiment 4 60 20 Embodiment 4 60 30

[0055] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound, characterized in that: It includes 70%-80% main medicinal ingredients, 1%-3% antioxidants, 2%-5% stabilizers, 10%-20% flavoring agents, and 2.9%-4.7% pH adjusters; the main medicinal ingredients include: 35%-40% Codonopsis pilosula extract, 35%-40% Astragalus extract; the antioxidants include: 0.5%-1.5% vitamin C, 0.5%-1.5% tea polyphenols; the stabilizers include: 1%-3% xanthan gum, 1%-2% sodium alginate; the flavoring agents include: 8%-15% sucrose, 2%-5% honey.

2. The method for preparing a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound according to claim 1, characterized in that: The following steps are involved: S1. Preparation of Codonopsis pilosula extract: Grind Codonopsis pilosula into coarse powder, place in an extraction tank, add distilled water at a solid-liquid ratio of 1:10-12 g / mL, reflux extraction multiple times at a specified heating temperature, combine the extracts, and concentrate to a relative density of 1.1-1.260°C by a vacuum concentrator; S2. Preparation of Astragalus Extract: After crushing the Astragalus, put it into an extraction tank, add distilled water at a solid-liquid ratio of 1:10-12 g / mL, reflux extraction multiple times at a specified heating temperature, combine the extracts, and concentrate under reduced pressure to a relative density of 1.05-1.1560℃; S3. Antioxidant mixing: In a clean liquid preparation tank, accurately weigh 0.5%-1.5% vitamin C and 0.5%-1.5% tea polyphenols, add a small amount of distilled water and stir manually to dissolve; S4. Treatment of xanthan gum and sodium alginate: 1%-3% xanthan gum and 1%-2% sodium alginate are weighed according to the formula, and the xanthan gum is slowly added into warm water, and a stirrer is used to fully disperse the xanthan gum to form a colloidal solution; sodium alginate is soaked and swelled in a small amount of distilled water in another container, and then heated and stirred with a stirrer until it is completely dissolved, and then the two are mixed and added into the liquid preparation tank; S5. Addition of sucrose and honey: weigh 8%-15% sucrose, dissolve it in appropriate amount of hot water to make syrup, filter it and add it to the liquid preparation tank, then add 2%-5% pure honey; S6. Preparation of citric acid-sodium citrate buffer pair: According to product requirements, use citric acid-sodium citrate buffer pair or other suitable pH adjusters to adjust the pH value of the solution in the preparation tank to within the range of 2.9-4.7; S7. Mixing process: slowly add the Codonopsis extract and Astragalus extract to the liquid preparation tank and turn on the mixer; S8. Filtration and filling: Filter the mixed solution through a microporous filter membrane to remove insoluble particles and impurities in the solution, and then use aseptic filling equipment to fill the filtered clarified solution into a pre-sterilized packaging container, which is sealed and stored to obtain the finished product of the Codonopsis pilosula and Astragalus compound concentrated solution.

3. The method for preparing a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound according to claim 2, characterized in that: In step S1, the heating temperature is 80-90°C, the number of reflux extractions is 2-3 times, and the reflux time for each time is 1.5-2 hours.

4. The method for preparing a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound according to claim 2, characterized in that: In step S2, the heating temperature is 90-95°C, and the reflux extraction is performed 2-3 times, with each reflux time being 1-1.5 hours.

5. The method for preparing a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound according to claim 2, characterized in that: In step S4, the temperature of the warm water added to the xanthan gum is specifically 50-60°C.

6. The method for preparing a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound according to claim 2, characterized in that: In step S4, the stirring time of the xanthan gum is 30-45 minutes.

7. The method for preparing a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound according to claim 2, characterized in that: In step S4, the heating temperature of sodium alginate is 75-85° C., and the stirring time of the stirrer is 30-45 minutes.

8. The method for preparing a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound according to claim 2, characterized in that: In step S7, the stirring speed of the stirrer is 200-300 r / min, and the stirring time is 30-60 minutes.

9. The method for preparing a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound according to claim 2, characterized in that: In step S8, the mesh size of the microporous filter membrane is specifically 0.22-0.45 μm.

10. An application of a concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound, characterized in that: The concentrated solution of Codonopsis pilosula and Astragalus membranaceus compound as claimed in claim 1 is used in the field of food, especially in the field of traditional Chinese medicine and health food.

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