Sample analyzer and control method of ultrasonic device thereof

Abstract

The invention is applicable to the field of in-vitro diagnostic equipment, and discloses a sample analyzer. The sample analyzer comprises a sample distribution device, a reagent distribution device, an ultrasonic device, a determination device and a control device, the ultrasonic device comprises an ultrasonic transducer and an ultrasonic vibration piece, and the ultrasonic vibration piece is provided with an ultrasonic wave transmission end; the control device is configured to control the ultrasonic transducer to drive the ultrasonic vibration piece to transmit ultrasonic waves to a reference medium under the condition that the ultrasonic wave transmission end is in contact with the reference medium so as to execute frequency locking operation, and a target electric signal corresponding to a target driving frequency is obtained; and controlling the ultrasonic transducer to drive the ultrasonic vibration piece to transmit ultrasonic waves to the target liquid at the target driving frequency so as to perform ultrasonic uniform mixing work on the target liquid. The frequency locking operation is executed under the working condition of the reference medium, the frequency locking operation is not carried out any more when ultrasonic mixing work is carried out on the target liquid, and interference of disturbance of the target liquid on the driving frequency of the ultrasonic mixing work is avoided.

Description

Technical Field

[0001] The present invention relates to the field of in vitro diagnostic equipment, and in particular to a sample analyzer and a control method for an ultrasonic device in the sample analyzer. Background Art

[0002] A sample analyzer provided by the related art is provided with an ultrasonic device for ultrasonically mixing liquids. The ultrasonic device can convert the input AC excitation signal into the same-frequency vibration at the end of the ultrasonic vibration rod to mix the liquid. When the driving frequency of the electric excitation signal falls within the natural frequency of the ultrasonic device, the output amplitude is the largest. However, the natural frequency of the ultrasonic device is generally different between different components and changes with the use time and working status.

[0003] In order to make the ultrasonic device work continuously and efficiently, the control device of the ultrasonic device needs to have a frequency locking function. The methods for implementing the frequency locking function in the related art include: (1) using a high-speed data acquisition module to collect the signal waveforms of the current working voltage and working current of the ultrasonic device, calculate the impedance phase, and adjust the output frequency of the control device in real time according to the current impedance phase; (2) based on the phase-locked loop, according to the phase difference between the working voltage and working current of the ultrasonic device, adjust the frequency of the output voltage of the control device so that the absolute values ​​of the working voltage and working current of the ultrasonic device are less than the given values. At this time, the corresponding driving voltage frequency is close to the resonant frequency of the ultrasonic device.

[0004] However, the above two frequency locking schemes have shortcomings in practical applications, which are as follows: (1) The scheme of frequency locking based on the original signal waveform of the working voltage and working current. Since the ultrasonic device generally works at a higher frequency, this scheme has relatively high requirements on the hardware performance and algorithm design, resulting in high cost. (2) The frequency locking scheme based on the phase-locked loop. Although the hardware is economical and simple, it can identify the differences between different components of the same ultrasonic device and the attenuation variation caused by work to achieve frequency locking. However, when the load impedance disturbance of the ultrasonic device is severe, it is easy to cause loss of lock, making the drive of the ultrasonic device ineffective. Summary of the invention

[0005] The first object of the present invention is to provide a sample analyzer, which aims to solve the technical problem in the related art that the ultrasonic device is greatly disturbed by the load impedance when working.

[0006] To achieve the above object, the present invention provides a solution: a sample analyzer, comprising:

[0007] A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container;

[0008] A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container;

[0009] An ultrasonic device, the ultrasonic device comprising an ultrasonic transducer and an ultrasonic vibrator, the ultrasonic vibrator being used to ultrasonically mix the target liquid under the drive of the ultrasonic transducer, the ultrasonic vibrator having an ultrasonic transmission end away from the ultrasonic transducer, the target liquid being one of the sample, the reagent, and a mixed liquid containing at least the sample and the reagent;

[0010] a measuring device for measuring a reaction solution made of at least a mixed solution;

[0011] A control device, wherein the control device is configured to: control the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation when the ultrasonic transmission end is in contact with the reference medium, and obtain a target electrical signal corresponding to a target driving frequency;

[0012] The control device is further configured to: control the ultrasonic transducer to drive the ultrasonic vibrator at the target driving frequency to transmit ultrasonic waves to the target liquid when the ultrasonic transmission end is in contact with the target liquid, so as to perform ultrasonic mixing on the target liquid;

[0013] The reference medium is a medium whose physical properties and / or composition are different from those of the target liquid.

[0014] As an implementation mode, the control device includes a frequency modulation circuit, a fixed frequency circuit, a drive circuit and a controller;

[0015] The output end of the driving circuit is connected to the ultrasonic transducer;

[0016] The output end of the frequency modulation circuit and the output end of the fixed frequency circuit are switchably connected to the input end of the driving circuit, the output end of the frequency modulation circuit is used to output a first driving electrical signal to the driving circuit when the ultrasonic device performs the frequency locking operation, and the output end of the fixed frequency circuit is used to output a second driving electrical signal corresponding to the target electrical signal to the driving circuit when the ultrasonic device performs the ultrasonic mixing operation;

[0017] The input end of the frequency modulation circuit is connected to the ultrasonic transducer, and the frequency modulation circuit is used to collect the working electrical signal of the ultrasonic transducer and adjust the first driving electrical signal output to the driving circuit according to the collected working electrical signal;

[0018] The controller is connected to the frequency modulation circuit and the fixed frequency circuit respectively;

[0019] The controller is configured to:

[0020] When controlling the ultrasonic device to perform the frequency locking operation, controlling the output end of the frequency modulation circuit to be connected to the input end of the driving circuit, and acquiring the target electrical signal corresponding to the target driving frequency by collecting the electrical signal of the frequency modulation circuit;

[0021] When controlling the ultrasonic device to perform the ultrasonic mixing operation, the output end of the fixed frequency circuit is controlled to be connected to the input end of the driving circuit, so that the driving circuit drives the ultrasonic transducer to operate under the drive of the second driving electrical signal.

[0022] As an implementation mode, the frequency modulation circuit includes a phase comparator, a first voltage acquisition circuit, a current acquisition circuit and a first voltage-controlled oscillator, wherein the first voltage acquisition circuit is connected between the ultrasonic transducer and a first input terminal of the phase comparator, the current acquisition circuit is connected between the ultrasonic transducer and a second input terminal of the phase comparator, and the first voltage-controlled oscillator is connected between an output terminal of the phase comparator and the driving circuit;

[0023] The fixed frequency circuit includes a DC power supply and a second voltage-controlled oscillator, the input end of the DC power supply is connected to the controller, and the second voltage-controlled oscillator is connected between the output end of the DC power supply and the driving circuit;

[0024] The first voltage-controlled oscillator and the second voltage-controlled oscillator are the same voltage-controlled oscillator or two independent voltage-controlled oscillators.

[0025] As an implementation manner, the first voltage-controlled oscillator and the second voltage-controlled oscillator are the same voltage-controlled oscillator;

[0026] The control device further comprises a switching module, wherein two input terminals of the switching module are respectively connected to the output terminal of the phase comparator and the output terminal of the DC power supply, the output terminal of the switching module is connected to the input terminal of the first voltage-controlled oscillator, and the control terminal of the switching module is connected to the controller;

[0027] The controlling the output end of the frequency modulation circuit to be connected to the input end of the driving circuit comprises: controlling the switching module to connect the output end of the phase comparator with the input end of the first voltage-controlled oscillator, so that the output end of the phase comparator is connected to the input end of the driving circuit via the first voltage-controlled oscillator;

[0028] The controlling the output end of the fixed frequency circuit to be connected to the input end of the driving circuit includes: controlling the switching module to connect the output end of the DC power supply with the input end of the first voltage-controlled oscillator, so that the output end of the DC power supply is connected to the input end of the driving circuit via the first voltage-controlled oscillator.

[0029] As an implementation mode, the control device further includes an electrical signal acquisition circuit, and the controller is connected to the output end of the phase comparator via the electrical signal acquisition circuit;

[0030] The controller is also configured to: in the process of controlling the ultrasonic device to perform the frequency locking operation, obtain the target electrical signal corresponding to the target driving frequency according to the electrical signal collected by the electrical signal acquisition circuit; in the process of controlling the ultrasonic device to perform the ultrasonic mixing operation, control the DC power supply to output the target electrical signal to the first voltage-controlled oscillator.

[0031] As an implementation manner, the target electrical signal is a voltage signal; and / or,

[0032] The switching module is a switch controlled by a digital signal.

[0033] As an embodiment, the controlling of the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation when the ultrasonic transmission end is in contact with the reference medium to obtain a target electrical signal corresponding to a target driving frequency includes: in the process of controlling the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation, the phase comparator adjusts the electrical signal output to the first voltage-controlled oscillator according to the phase difference between the voltage signal collected by the first voltage collection circuit and the current signal collected by the current collection circuit until a preset condition is met, and the controller determines the electrical signal output by the phase comparator to the first voltage-controlled oscillator when the preset condition is met as the target electrical signal corresponding to the target driving frequency; or,

[0034] The controlling of the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation when the ultrasonic transmission end is in contact with the reference medium to obtain a target electrical signal corresponding to a target driving frequency includes: in the process of controlling the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation, the phase comparator adjusts the electrical signal output to the first voltage-controlled oscillator according to the phase difference between the voltage signal collected by the first voltage collection circuit and the current signal collected by the current collection circuit until a preset condition is met, and the controller determines the sum of the electrical signal output by the phase comparator to the first voltage-controlled oscillator when the preset condition is met and a preset compensation electrical signal as the target electrical signal corresponding to the target driving frequency.

[0035] As an implementation manner, the preset condition includes that the execution time of the frequency locking operation reaches a preset time.

[0036] As an embodiment, the ultrasonic device further includes a driving mechanism, and the control device is further configured to: before controlling the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the target liquid at the target driving frequency to perform ultrasonic mixing on the target liquid, control the driving mechanism to drive the ultrasonic vibrator to move to the ultrasonic mixing position;

[0037] The control device is further configured to: after controlling the ultrasonic device to perform the frequency locking operation and before controlling the driving mechanism to drive the ultrasonic vibrator to move to the ultrasonic mixing position, control the ultrasonic transducer to turn off;

[0038] After the ultrasonic vibrator moves to the ultrasonic mixing position, the ultrasonic transducer is controlled to start, and the ultrasonic transducer is driven to work at the target driving frequency to drive the ultrasonic vibrator to ultrasonically mix the target liquid located at the ultrasonic mixing position.

[0039] As an embodiment, the control device is further configured to: before performing ultrasonic mixing on the target liquid in the first sample measurement item of a batch of samples, control the ultrasonic transducer to perform the frequency locking operation; or,

[0040] The control device is further configured to: before performing ultrasonic mixing on the target liquid in the first sample measurement item after the sample analyzer is turned on, control the ultrasonic transducer to perform the frequency locking operation; or,

[0041] The control device is further configured to: before performing ultrasonic mixing on the target liquid in the first sample measurement item after the sample analyzer is restarted from standby, control the ultrasonic transducer to perform the frequency locking operation; or,

[0042] The control device is further configured to: control the ultrasonic transducer to perform the frequency locking operation before performing ultrasonic mixing on the target liquid in the first sample measurement item after the sample analyzer is restarted after maintenance; or,

[0043] The control device is further configured to control the ultrasonic transducer to perform the frequency locking operation before performing the ultrasonic mixing operation on the target liquid in each of the sample measurement items.

[0044] As an implementation mode, the reference medium is air, and the situation in which the ultrasonic transmission end contacts the reference medium is that the ultrasonic vibrator is in a no-load situation; or,

[0045] The reference medium is a reference solid, and the situation in which the ultrasonic transmission end contacts the reference medium is the situation in which the ultrasonic transmission end contacts the reference solid; or,

[0046] The reference medium is a reference liquid with known physical properties and / or known components, and the situation in which the ultrasonic transmission end contacts the reference medium is a situation in which the ultrasonic transmission end is inserted into the reference liquid.

[0047] A second object of the present invention is to provide a sample analyzer, the sample analyzer comprising:

[0048] A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container;

[0049] A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container;

[0050] An ultrasonic device, the ultrasonic device comprising an ultrasonic transducer and an ultrasonic vibrator, the ultrasonic vibrator being used to transmit ultrasonic waves to the target liquid under the drive of the ultrasonic transducer, the target liquid being one of the sample, the reagent, a cleaning liquid, and a mixed liquid containing at least the sample and the reagent;

[0051] a measuring device for measuring a reaction solution made of at least a mixed solution;

[0052] A control device, the control device comprising a frequency modulation circuit, a fixed frequency circuit and a drive circuit, wherein an output end of the drive circuit is connected to the ultrasonic transducer to drive the ultrasonic transducer to work;

[0053] The output end of the frequency modulation circuit and the output end of the fixed frequency circuit are switchably connected to the input end of the driving circuit, the output end of the frequency modulation circuit is used to output a first driving electrical signal to the driving circuit when the ultrasonic device performs a frequency locking operation, and the output end of the fixed frequency circuit is used to output a second driving electrical signal to the driving circuit when the ultrasonic device performs an ultrasonic mixing operation;

[0054] The input end of the frequency modulation circuit is connected to the ultrasonic transducer, and the frequency modulation circuit is used to collect the working electrical signal of the ultrasonic transducer and adjust the first driving electrical signal output to the driving circuit according to the collected working electrical signal.

[0055] As an implementation mode, the frequency modulation circuit includes a phase comparator, a first voltage acquisition circuit, a current acquisition circuit and a first voltage-controlled oscillator, wherein the first voltage acquisition circuit is connected between the ultrasonic transducer and a first input terminal of the phase comparator, the current acquisition circuit is connected between the ultrasonic transducer and a second input terminal of the phase comparator, and the first voltage-controlled oscillator is connected between an output terminal of the phase comparator and the driving circuit;

[0056] The fixed frequency circuit includes a DC power supply and a second voltage-controlled oscillator, the input end of the DC power supply is connected to the controller, and the second voltage-controlled oscillator is connected between the output end of the DC power supply and the driving circuit;

[0057] The first voltage-controlled oscillator and the second voltage-controlled oscillator are the same voltage-controlled oscillator or two independent voltage-controlled oscillators.

[0058] As an implementation manner, the first voltage-controlled oscillator and the second voltage-controlled oscillator are the same voltage-controlled oscillator;

[0059] The control device further comprises a switching module and a controller, wherein two input ends of the switching module are respectively connected to the output end of the phase comparator and the output end of the DC power supply, and the output end of the switching module is connected to the input end of the first voltage-controlled oscillator;

[0060] The control end of the switching module is connected to the controller, and the controller is used to control the switching module to switch between the following working states: connecting the output end of the phase comparator with the input end of the first voltage-controlled oscillator, and connecting the output end of the DC power supply with the input end of the first voltage-controlled oscillator.

[0061] As an implementation mode, the control device further includes an electrical signal acquisition circuit, and the controller is connected to the output end of the phase comparator via the electrical signal acquisition circuit;

[0062] The controller is used to: in the process of controlling the ultrasonic device to perform the frequency locking operation, obtain a target electrical signal corresponding to the target driving frequency according to the electrical signal fed back by the electrical signal acquisition circuit;

[0063] The controller is also used to: control the DC power supply to output the target electrical signal to the first voltage-controlled oscillator during the process of controlling the ultrasonic device to perform the ultrasonic mixing operation.

[0064] As an embodiment, obtaining a target electrical signal corresponding to a target driving frequency according to the electrical signal fed back by the electrical signal acquisition circuit comprises: in the process of controlling the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation, the phase comparator adjusts the electrical signal output to the first voltage-controlled oscillator according to the phase difference between the voltage signal acquired by the first voltage acquisition circuit and the current signal acquired by the current acquisition circuit until a preset condition is met, and the controller determines the electrical signal output by the phase comparator to the first voltage-controlled oscillator when the preset condition is met as the target electrical signal corresponding to the target driving frequency, wherein the preset condition comprises that the execution time of the frequency locking operation reaches a preset time; or,

[0065] The target electrical signal corresponding to the target driving frequency is obtained according to the electrical signal fed back by the electrical signal acquisition circuit, comprising: in the process of controlling the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation, the phase comparator adjusts the electrical signal output to the first voltage-controlled oscillator according to the phase difference between the voltage signal collected by the first voltage acquisition circuit and the current signal collected by the current acquisition circuit until a preset condition is met, and the controller determines the sum of the electrical signal output by the phase comparator to the first voltage-controlled oscillator when the preset condition is met and a preset compensation electrical signal as the target electrical signal corresponding to the target driving frequency, wherein the preset condition includes that the execution time of the frequency locking operation reaches a preset time.

[0066] A second object of the present invention is to provide a method for controlling an ultrasonic device in a sample analyzer, the method comprising the following steps:

[0067] Controlling the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium when the ultrasonic transmission end is in contact with the reference medium to perform a frequency locking operation, thereby obtaining a target electrical signal corresponding to a target driving frequency;

[0068] Controlling the ultrasonic transducer to drive the ultrasonic vibrator at the target driving frequency to transmit ultrasonic waves to the target liquid when the ultrasonic transmission end is in contact with the target liquid, so as to perform ultrasonic mixing on the target liquid;

[0069] The reference medium is a medium whose physical properties and / or composition are different from those of the target liquid.

[0070] The sample analyzer and the control method of the ultrasonic device in the sample analyzer provided by the present invention obtain a target electrical signal corresponding to the target driving frequency by controlling the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium under the working condition of the reference medium before the ultrasonic device performs ultrasonic mixing on the target liquid to perform a frequency locking operation, that is, the frequency locking operation is performed before the ultrasonic mixing on the target liquid and under the working condition of the reference medium, rather than under the working condition of the target liquid; and when the ultrasonic mixing on the target liquid is performed, the frequency locking operation is no longer performed, thereby effectively avoiding the disturbance of the target liquid causing the load impedance to interfere with the driving frequency of the ultrasonic device when performing the ultrasonic mixing, and ensuring the stability, reliability and effectiveness of the ultrasonic mixing of the target liquid by the ultrasonic device. BRIEF DESCRIPTION OF THE DRAWINGS

[0071] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.

[0072] Figure 1 is a schematic diagram of the composition of a sample analyzer provided by an embodiment of the present invention;

[0073] Figure 2 is a schematic diagram of the structure of a sample analyzer provided by an embodiment of the present invention;

[0074] Figure 3 is a schematic diagram of ultrasonic mixing of a target liquid by an ultrasonic device provided in an embodiment of the present invention;

[0075] Figure 4 is a schematic diagram of the composition of a control device provided by an embodiment of the present invention;

[0076] Figure 5 It is a circuit connection diagram of an ultrasonic control board and an ultrasonic transducer provided in an embodiment of the present invention.

[0077] Description of the accompanying drawings: 10, sample analyzer; 100, ultrasonic device; 110, ultrasonic transducer; 111, piezoelectric ceramic component; 120, ultrasonic vibrator; 121, ultrasonic transmission end; 200, control device; 210, ultrasonic control board; 211, drive circuit; 212, frequency modulation circuit; 2121, phase comparator; 2122, first voltage acquisition circuit; 2123, current acquisition circuit; 2124, first voltage controlled oscillator; 213, fixed frequency circuit; 21 31. DC power supply; 214. Controller; 215. Switching module; 216. Electrical signal acquisition circuit; 220. Main control board; 300. Sample dispensing device; 400. Reagent dispensing device; 500. Measurement device; 600. Reagent loading device; 700. Incubation device; 800. Transfer device; 900. Reaction container providing device; 101. Sample management device; 102. Sample transport device; 103. Magnetic separation device; 20. Target liquid; 30. Reaction container. DETAILED DESCRIPTION

[0078] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0079] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back, etc.) are only used to explain the relative position relationship, movement status, etc. between the components in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0080] It should also be noted that when an element is referred to as being "fixed on" or "disposed on" another element, it may be directly on the other element or there may be an intermediate element at the same time. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or may be indirectly connected to the other element through an intermediate element.

[0081] In addition, the descriptions of "first", "second", etc. in the present invention are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the ability of ordinary technicians in the field to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0082] Embodiment 1:

[0083] like Figures 1 to 5 As shown, the sample analyzer 10 provided in the first embodiment of the present invention includes an ultrasonic device 100, and the ultrasonic device 100 is used to ultrasonically mix the target liquid 20, and the target liquid 20 is one of a sample, a reagent, and a mixed liquid containing at least a sample and a reagent. The ultrasonic device 100 achieves the effect of mixing the target liquid 20 by transmitting ultrasonic waves to the target liquid 20. The use of the ultrasonic device 100 to mix the target liquid 20 has the characteristic of high mixing efficiency, which is conducive to improving the sample measurement efficiency of the sample analyzer 10.

[0084] As an embodiment, the ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, and the ultrasonic vibrator 120 is used to ultrasonically mix the target liquid 20 under the drive of the ultrasonic transducer 110. The ultrasonic vibrator 120 is connected to the ultrasonic transducer 110. The ultrasonic transducer 110 is an energy conversion device, which is mainly used to convert the electrical power input thereto into mechanical power (i.e., ultrasonic waves) and then transmit it out.

[0085] As an implementation mode, the ultrasonic transducer 110 includes a piezoelectric ceramic component 111. The piezoelectric ceramic component 111 is a component made of an electronic ceramic material having piezoelectric and sensitive properties, and can realize mutual conversion between mechanical energy and electrical energy.

[0086] As an embodiment, the ultrasonic vibrator 120 has an ultrasonic transmission end 121 away from the ultrasonic transducer 110. The ultrasonic transmission end 121 is specifically an end surface of the ultrasonic vibrator 120 away from the ultrasonic transducer 110. The ultrasonic transmission end 121 is the main output surface of the ultrasonic vibrator 120 for transmitting ultrasonic waves outward.

[0087] As an embodiment, the ultrasonic vibrator 120 is an ultrasonic vibrator rod for at least partially inserting into the target liquid 20 for ultrasonic mixing. The ultrasonic vibrator 120 transmits ultrasonic waves to the target liquid 20 by contact, which helps to reduce the interference of other external components on the ultrasonic transmission.

[0088] As an implementation mode, the ultrasonic vibration rod is a horn. The ultrasonic transmission end 121 is specifically an end surface of the ultrasonic vibration rod away from the ultrasonic transducer 110 .

[0089] As an embodiment, the ultrasonic device 100 further includes a driving mechanism, and the ultrasonic transducer 110 and / or the ultrasonic vibrator 120 are connected to the driving mechanism, and the driving mechanism is used to drive the ultrasonic transducer 110 and the ultrasonic vibrator 120 to move. The driving mechanism is used to drive the ultrasonic vibrator 120 to move in two-dimensional or three-dimensional space, so that the ultrasonic vibrator 120 moves to different positions, such as a standby position, an ultrasonic mixing position, a cleaning position, etc.

[0090] As an embodiment, the sample analyzer 10 further includes a control device 200, which is used to control the operation of the ultrasonic device 100. Specifically, the control device 200 is electrically connected to the ultrasonic transducer 110 to control the operation of the ultrasonic transducer 110. The ultrasonic transducer 110 is used to convert the electrical power input by the control device 200 into mechanical power (i.e., ultrasonic waves) and then transmit it out.

[0091] As an embodiment, the control device 200 is configured with a frequency locking mode and an ultrasonic mixing mode. In the frequency locking mode, the control device 200 is configured to: control the ultrasonic device 100 to perform a frequency locking operation to obtain a target electrical signal corresponding to the target driving frequency. In the ultrasonic mixing mode, the control device 200 is configured to: drive the ultrasonic device 100 to transmit ultrasonic waves to the target liquid 20 at the target driving frequency, so as to perform ultrasonic mixing on the target liquid 20, so as to obtain a target electrical signal corresponding to the target driving frequency. The frequency locking operation is mainly used to determine the target driving frequency of the ultrasonic device 100, so that in the ultrasonic mixing operation, the ultrasonic device 100 is driven to transmit ultrasonic waves to the target liquid 20 at the target driving frequency, so that the ultrasonic mixing effect can be achieved in a shorter time.

[0092] As an implementation, the target driving frequency is used to indicate that the ultrasonic device 100 operates within a preset range of the resonant frequency. The electromechanical conversion efficiency of the ultrasonic device 100 is the highest when it operates at its resonant frequency.

[0093] As an embodiment, the control device 200 is configured to: control the ultrasonic transducer 110 to drive the ultrasonic vibrator 120 to transmit ultrasonic waves to the reference medium when the ultrasonic transmission end 121 is in contact with the reference medium to perform a frequency locking operation, and obtain a target electrical signal corresponding to the target driving frequency, that is, the frequency locking operation is performed under the working condition of the reference medium. Under the working condition of the reference medium, the ultrasonic transmission end 121 is in contact with the reference medium, and the ultrasonic vibrator 120 is in contact with the reference medium but not in contact with the target liquid 20. In this embodiment, the frequency locking operation is performed under the working condition of the reference medium, rather than under the working condition of the target liquid 20, which can avoid the influence of the disturbance of the target liquid 20 on the frequency locking operation.

[0094] As an implementation manner, the reference medium is a medium different from the target liquid 20 , that is, the reference medium and the target liquid 20 are two different media.

[0095] As an embodiment, the reference medium is a medium different from the target liquid 20, including: the reference medium is a medium whose physical properties and / or composition are different from the target liquid 20. The difference in physical properties of the two media includes at least one of the following situations: different density, different sound propagation speed, and different viscosity. The difference in composition of the two media means that the components of the two media are different.

[0096] As an implementation mode, the reference medium is air. The situation in which the ultrasonic transmission end 121 contacts the reference medium is the situation in which the ultrasonic vibrator 120 is unloaded. The ultrasonic device 100 transmits ultrasonic waves to the reference medium under the working condition of the reference medium, specifically, the ultrasonic device 100 transmits ultrasonic waves to the air, that is, the ultrasonic device 100 works under the working condition of no load. In this implementation mode, the reference medium is set as air. On the one hand, it can save the preparation time of the reference medium and the supply device of the reference medium, thereby helping to reduce the frequency locking operation time and frequency locking operation cost of the ultrasonic device 100; on the other hand, air is relatively stable and has little disturbance. Of course, in specific applications, the setting method of the reference medium is not limited to this. As an alternative embodiment, the reference medium can also be other stable media, such as a reference solid or a reference liquid with known physical properties and / or known components (such as purified water or a diluent contained in the reaction vessel 30); wherein, when the reference medium is a reference solid, the working condition of the ultrasonic vibrator 120 in the reference medium is the working condition that the ultrasonic vibrator 120 is in contact with the reference solid, and the situation that the ultrasonic transmission end 121 is in contact with the reference medium is the situation that the ultrasonic transmission end 121 is in contact with the reference solid; when the reference medium is a reference liquid with known physical properties and / or known components, the working condition of the ultrasonic vibrator 120 in the reference medium is the working condition that the ultrasonic vibrator 120 is at least partially inserted into the reference liquid, and the situation that the ultrasonic transmission end 121 is in contact with the reference medium is the situation that the ultrasonic transmission end 121 is inserted into the reference liquid.

[0097] As an embodiment, the control device 200 is further configured to: control the ultrasonic transducer 110 to drive the ultrasonic vibrator 120 at the target driving frequency to transmit ultrasonic waves to the target liquid 20 when the ultrasonic transmission end 121 is in contact with the target liquid 20, so as to perform ultrasonic mixing on the target liquid 20. That is, the ultrasonic mixing is performed under the working condition of the target liquid 20. Under the working condition of the target liquid 20, the ultrasonic vibrator 120 is in contact with the target liquid 20, and the ultrasonic transmission end 121 is in contact with the target liquid 20. In this embodiment, before the ultrasonic device 100 ultrasonically mixes the target liquid 20, a frequency locking operation is first performed in a reference medium to obtain a target driving frequency of the ultrasonic device 100, and the target liquid 20 is driven at the target driving frequency when ultrasonically mixing the target liquid 20, that is, when ultrasonically mixing the target liquid 20, no frequency locking operation is performed, thereby effectively avoiding the disturbance of the target liquid 20 causing the load impedance to interfere with the driving frequency of the ultrasonic device 100 during operation, thereby ensuring the stability, reliability and effectiveness of the ultrasonic mixing of the target liquid 20 by the ultrasonic device 100.

[0098] As an embodiment, the control device 200 is also configured to: before using the target driving frequency to drive the ultrasonic transducer 110 to work, control the driving mechanism to drive the ultrasonic vibrator 120 to at least partially insert into the target liquid 20 to ensure that the ultrasonic transmission end 121 of the ultrasonic vibrator 120 is in contact with the target liquid 20.

[0099] As an embodiment, the control device 200 is further configured to: before controlling the ultrasonic transducer 110 to drive the ultrasonic vibrator 120 to transmit ultrasonic waves to the target liquid 20 at the target driving frequency to perform ultrasonic mixing on the target liquid 20, control the driving mechanism to drive the ultrasonic vibrator 120 to move to the ultrasonic mixing position. The ultrasonic vibrator 120 is used to perform ultrasonic mixing on the target liquid 20 at the ultrasonic mixing position.

[0100] As an embodiment, the control device 200 is further configured to: after the ultrasonic device 100 is controlled to perform the frequency locking operation and before the driving mechanism is controlled to drive the ultrasonic vibrator 120 to move to the ultrasonic mixing position, control the ultrasonic transducer 110 to turn off; after the ultrasonic vibrator 120 moves to the ultrasonic mixing position, control the ultrasonic transducer 110 to start, and use the target driving frequency to drive the ultrasonic vibrator 120 to ultrasonically mix the target liquid 20 located at the ultrasonic mixing position. In this embodiment, after the frequency locking operation is performed, the ultrasonic transducer 110 is first turned off, and after the ultrasonic vibrator 120 moves to the ultrasonic mixing position, the ultrasonic transducer 110 is controlled to start. In this way, on the one hand, it can prevent the ultrasonic vibrator 120 from splashing when the target liquid 20 is inserted; on the other hand, it can help reduce energy consumption.

[0101] As an embodiment, the control device 200 is further configured to: before performing ultrasonic mixing on the target liquid 20 in the first sample measurement project of a batch of samples, control the ultrasonic transducer 110 to perform a frequency locking operation. In this embodiment, the execution time of the frequency locking operation is set with reference to the first sample measurement project of a batch of samples, and the frequency locking operation is only performed before the first sample measurement project of a batch of samples, and it is not necessary to perform the frequency locking operation before each sample measurement project, so that the frequency locking operation does not occupy the time of ultrasonic mixing, thereby helping to reduce the duration of the ultrasonic mixing cycle of the sample measurement project, and ultimately helping to improve the measurement throughput of the sample analyzer 10.

[0102] Of course, in specific applications, the execution time of the frequency locking operation is not limited to being set with reference to the first sample measurement item of a batch of samples. For example, as an alternative implementation, the execution time of the frequency locking operation can also be set with reference to the startup of the sample analyzer 10. Specifically, in this alternative implementation, the control device 200 is further configured to control the ultrasonic transducer 110 to perform the frequency locking operation before performing ultrasonic mixing on the target liquid 20 in the first sample measurement item after the sample analyzer 10 is started.

[0103] Alternatively, as another alternative embodiment, the execution time of the frequency locking operation can also be set with reference to the standby restart of the sample analyzer 10. Specifically, in this alternative embodiment, the control device 200 is further configured to control the ultrasonic transducer 110 to perform the frequency locking operation before performing ultrasonic mixing on the target liquid 20 in the first sample measurement item after the standby restart measurement of the sample analyzer 10.

[0104] Alternatively, as another alternative embodiment, the execution time of the frequency locking operation can also be set with reference to the restart of the sample analyzer 10 after maintenance is completed. Specifically, in this alternative embodiment, the control device 200 is further configured to: control the ultrasonic transducer 110 to perform the frequency locking operation before performing ultrasonic mixing on the target liquid 20 in the first sample measurement item after the sample analyzer 10 is restarted after maintenance is completed.

[0105] Alternatively, as another alternative embodiment, the execution time of the frequency locking operation can also be set with reference to the sample measurement item. Specifically, in this alternative embodiment, the control device 200 is also configured to control the ultrasonic transducer 110 to perform the frequency locking operation before performing ultrasonic mixing on the target liquid 20 in each sample measurement item.

[0106] As an implementation manner, the control device 200 includes a driving circuit 211, and an output end of the driving circuit 211 is connected to the ultrasonic transducer 110. The driving circuit 211 is used to drive the ultrasonic transducer 110 to work.

[0107] As an embodiment, the control device 200 further includes a frequency modulation circuit 212, the output end of the frequency modulation circuit 212 is connected to the input end of the driving circuit 211, and the output end of the frequency modulation circuit 212 is used to output a first driving electrical signal to the driving circuit 211 when the ultrasonic device 100 performs a frequency locking operation. The input end of the frequency modulation circuit 212 is connected to the ultrasonic transducer 110, and the frequency modulation circuit 212 is used to collect the working electrical signal of the ultrasonic transducer 110 and adjust the first driving electrical signal output to the driving circuit 211 according to the collected working electrical signal. During the frequency locking operation, the first driving electrical signal changes. The frequency modulation circuit 212 is mainly used to collect the working electrical signal of the ultrasonic transducer 110, and adjust the driving frequency of the ultrasonic device 100 to obtain a target electrical signal corresponding to the resonant frequency.

[0108] As an implementation mode, the control device 200 further includes a fixed frequency circuit 213, the output end of the fixed frequency circuit 213 is switchably connected to the input end of the driving circuit 211, and the output end of the fixed frequency circuit 213 is used to output a second driving electrical signal corresponding to the target electrical signal to the driving circuit 211 when the ultrasonic device 100 performs ultrasonic mixing. After the frequency locking operation is completed, the second driving electrical signal output by the fixed frequency circuit 213 is a determined fixed value, and the second driving electrical signal will not change during the ultrasonic mixing operation. In this implementation mode, when the driving circuit 211 performs the frequency locking operation and the ultrasonic mixing operation, the driving circuit 211 provides the driving electrical signal through two different circuits, namely the frequency modulation circuit 212 and the fixed frequency circuit 213, respectively. In this way, it is beneficial to ensure that the frequency locking operation can achieve frequency modulation, and it is also possible to avoid the disturbance of the target liquid 20 causing the load impedance to interfere with the driving frequency of the ultrasonic device 100 during the ultrasonic mixing operation.

[0109] As an implementation mode, the output end of the frequency modulation circuit 212 and the output end of the fixed frequency circuit 213 can be switchably connected to the input end of the driving circuit 211. The input end of the driving circuit 211 selects one of the output end of the frequency modulation circuit 212 and the output end of the fixed frequency circuit 213 to provide a driving electrical signal, that is, the input end of the driving circuit 211 can be selectively connected to one of the output end of the frequency modulation circuit 212 and the output end of the fixed frequency circuit 213.

[0110] As an implementation, the control device 200 further includes a controller 214, which is respectively connected to the frequency modulation circuit 212 and the fixed frequency circuit 213. The controller 214 is at least used to control the input end of the driving circuit 211 to switch between the output end of the frequency modulation circuit 212 and the output end of the fixed frequency circuit 213.

[0111] As an embodiment, the controller 214 is configured to: when controlling the ultrasonic device 100 to perform a frequency locking operation, control the output end of the frequency modulation circuit 212 to be connected to the input end of the driving circuit 211, and obtain a target electrical signal corresponding to the target driving frequency by collecting the electrical signal of the frequency modulation circuit 212; when controlling the ultrasonic device 100 to perform an ultrasonic mixing operation, control the output end of the fixed frequency circuit 213 to be connected to the input end of the driving circuit 211, so that the driving circuit 211 drives the ultrasonic transducer 110 to work under the drive of the second driving electrical signal. In this embodiment, the controller 214 controls the output end of the frequency modulation circuit 212 and the output end of the fixed frequency circuit 213 to be selectively connected to the input end of the driving circuit 211, so that the frequency locking operation and ultrasonic mixing operation of the ultrasonic device 100 can be automatically performed under the control of the controller 214.

[0112] As an implementation method, the target electrical signal is a voltage signal. In the frequency locking operation, the voltage signal corresponding to the target driving frequency is obtained through the frequency modulation circuit 212; in the ultrasonic mixing operation, the fixed frequency circuit 213 is controlled to output the voltage signal corresponding to the target electrical signal. Setting the target electrical signal as a voltage signal is easy to collect and control the output, and no complicated calculation processing is required between collection and output.

[0113] As an implementation mode, the frequency modulation circuit 212 includes a phase comparator 2121, a first voltage acquisition circuit 2122, a current acquisition circuit 2123 and a first voltage-controlled oscillator 2124. The first voltage acquisition circuit 2122 is connected between the ultrasonic transducer 110 and the first input terminal of the phase comparator 2121, the current acquisition circuit 2123 is connected between the ultrasonic transducer 110 and the second input terminal of the phase comparator 2121, and the first voltage-controlled oscillator 2124 is connected between the output terminal of the phase comparator 2121 and the driving circuit 211. The first current acquisition circuit 2123 is mainly used to acquire the current signal (working current waveform) of the ultrasonic device 100, the first voltage acquisition circuit 2122 is mainly used to acquire the voltage signal (working voltage waveform) of the ultrasonic device 100, the phase comparator 2121 outputs a voltage signal for representing the phase to the first voltage-controlled oscillation circuit according to the phase difference between the working voltage and the working current of the ultrasonic device 100, and the first voltage-controlled oscillation circuit outputs a waveform signal with a certain frequency to the driving circuit 211 according to the voltage signal output by the phase comparator 2121. In the frequency-locked operation, for different phase differences between the working voltage and the working current of the ultrasonic device 100, the frequency of the waveform signal output by the first voltage-controlled oscillation circuit to the driving circuit 211 is different to achieve frequency modulation control. In this embodiment, the voltage signal output by the phase comparator 2121 is converted into a waveform signal with a certain frequency by the first voltage-controlled oscillator 2124, which has the characteristic of simple control. Of course, in specific applications, the setting method of the frequency modulation circuit 212 is not limited to this. For example, as an alternative implementation scheme, the first voltage-controlled oscillation circuit may not be set. The phase comparator 2121 directly feeds back the phase difference between the working voltage and the working current of the ultrasonic device 100 to the controller 214, and the controller 214 controls the output of a waveform signal with a certain frequency to the drive circuit 211.

[0114] As an implementation mode, the fixed frequency circuit 213 includes a DC power supply 2131 and a second voltage-controlled oscillator, the input end of the DC power supply 2131 is connected to the controller 214, and the second voltage-controlled oscillator is connected between the output end of the DC power supply 2131 and the driving circuit 211; wherein the first voltage-controlled oscillator 2124 and the second voltage-controlled oscillator are the same voltage-controlled oscillator. The DC power supply 2131 is used to output a DC voltage signal to the second voltage-controlled oscillator circuit under the control of the controller 214, and the second voltage-controlled oscillator circuit outputs a waveform signal with a certain frequency to the driving circuit 211 according to the phase signal of the DC output. Among them, the DC power supply 2131 outputs a DC voltage signal to the second voltage-controlled oscillator circuit, which corresponds to the target electrical signal obtained by the frequency modulation circuit 212 during the frequency locking operation. In this implementation mode, the frequency modulation circuit 212 and the fixed frequency circuit 213 share the same voltage-controlled oscillator, which is conducive to simplifying the structure of the control device 200 and reducing the cost of the control device 200. Of course, in a specific application, as an alternative implementation, the first voltage-controlled oscillator 2124 and the second voltage-controlled oscillator may also be two independent voltage-controlled oscillators.

[0115] As an implementation mode, the control device 200 further includes a switching module 215, two input ends of the switching module 215 are respectively connected to the output end of the phase comparator 2121 and the output end of the DC power supply 2131, the output end of the switching module 215 is connected to the input end of the first voltage-controlled oscillator 2124, and the control end of the switching module 215 is connected to the controller 214. Controlling the output end of the frequency modulation circuit 212 to be connected to the input end of the driving circuit 211 includes: controlling the switching module 215 to connect the output end of the phase comparator 2121 and the input end of the first voltage-controlled oscillator 2124, so that the output end of the phase comparator 2121 is connected to the input end of the driving circuit 211 via the first voltage-controlled oscillator 2124. Controlling the output end of the fixed frequency circuit 213 to be connected to the input end of the driving circuit 211 includes: controlling the switching module 215 to connect the output end of the DC power supply 2131 with the input end of the first voltage-controlled oscillator 2124, so that the output end of the DC power supply 2131 is connected to the input end of the driving circuit 211 via the first voltage-controlled oscillator 2124. In this embodiment, the controller 214 controls the switching module 215 to realize the automatic switching connection between the phase comparator 2121 of the frequency modulation circuit 212 and the DC power supply 2131 of the fixed frequency circuit 213 and the first voltage-controlled oscillator 2124, thereby realizing the automatic switching connection between the frequency modulation circuit 212 and the fixed frequency circuit 213 and the driving circuit 211.

[0116] As an implementation, the switching module 215 is a switch controlled by a digital signal, and has a simple structure and is easy to control. Of course, in a specific application, the configuration of the switching module 215 is not limited thereto. For example, as an alternative implementation, the switching module 215 may also be two electrical switches, one of which is used to control the on / off of the circuit between the output end of the phase comparator 2121 and the input end of the first voltage-controlled oscillator 2124, and the other electrical switch is used to control the on / off of the circuit between the output end of the DC power supply 2131 and the input end of the first voltage-controlled oscillator 2124.

[0117] As an implementation mode, the control device 200 further includes an electric signal acquisition circuit 216, and the controller 214 is connected to the output end of the phase comparator 2121 via the electric signal acquisition circuit 216; the controller 214 is further configured to: in the process of controlling the ultrasonic device 100 to perform the frequency locking operation, obtain the target electric signal corresponding to the target driving frequency according to the electric signal collected by the electric signal acquisition circuit 216; in the process of controlling the ultrasonic device 100 to perform the ultrasonic mixing operation, control the DC power supply 2131 to output the target electric signal to the first voltage-controlled oscillator 2124. In this implementation mode, the controller 214 obtains the target electric signal corresponding to the target driving frequency by collecting the electric signal output by the phase comparator 2121.

[0118] As an implementation method, the electric signal acquisition circuit 216 is a second voltage acquisition circuit, and the electric signal acquisition circuit 216 is used to acquire the voltage signal output by the phase comparator 2121. The controller 214 obtains the target electric signal corresponding to the target driving frequency by acquiring the voltage signal output by the phase comparator 2121. Of course, in a specific application, as an alternative implementation method, the electric signal acquisition circuit 216 can also be used to acquire the current signal output by the phase comparator 2121.

[0119] As an implementation mode, the ultrasonic transducer 110 is controlled to drive the ultrasonic vibrator 120 to transmit ultrasonic waves to the reference medium to perform a frequency locking operation when the ultrasonic transmission end 121 is in contact with the reference medium, and a target electrical signal corresponding to the target driving frequency is obtained, including: in the process of controlling the ultrasonic transducer 110 to drive the ultrasonic vibrator 120 to transmit ultrasonic waves to the reference medium to perform a frequency locking operation, the phase comparator 2121 adjusts the electrical signal output to the first voltage-controlled oscillator 2124 according to the phase difference between the voltage signal collected by the first voltage collection circuit 2122 and the current signal collected by the current collection circuit 2123 until the preset condition is met, and the controller 214 determines the electrical signal output by the phase comparator 2121 to the first voltage-controlled oscillator 2124 when the preset condition is met as the target electrical signal corresponding to the target driving frequency. The preset condition is a condition for characterizing whether the driving frequency of the ultrasonic device 100 reaches the resonant frequency. In this implementation mode, before the preset condition is met, the driving frequency output by the driving circuit 211 to the ultrasonic device 100 is adjusted by the frequency modulation circuit 212. When the preset conditions are met, the electrical signal output by the phase comparator 2121 to the first voltage-controlled oscillator 2124 when the preset conditions are met serves as the target electrical signal output by the DC power supply 2131 during the subsequent ultrasonic mixing process.

[0120] Of course, in specific applications, the method for determining the target electrical signal is not limited to the above-mentioned scheme. For example, as an alternative implementation scheme, before ultrasonic mixing, the frequency-locked circuit is used to obtain the preset conditions, and the phase comparator 2121 outputs the first voltage signal to the first voltage-controlled oscillator 2124 and compensates to obtain the second voltage signal. During the ultrasonic mixing operation, the DC power supply 2131 outputs the second voltage signal to the first voltage-controlled oscillator 2124, so that the drive circuit 211 outputs a frequency-compensated drive signal to the ultrasonic device 100. In this alternative embodiment, the above-mentioned control of the ultrasonic transducer 110 to drive the ultrasonic vibrator 120 to transmit ultrasonic waves to the reference medium to perform a frequency locking operation when the ultrasonic transmission end 121 is in contact with the reference medium, and obtains a target electrical signal corresponding to the target driving frequency, including: in the process of controlling the ultrasonic transducer 110 to drive the ultrasonic vibrator 120 to transmit ultrasonic waves to the reference medium to perform a frequency locking operation, the phase comparator 2121 adjusts the electrical signal output to the first voltage-controlled oscillator 2124 according to the phase difference between the voltage signal collected by the first voltage acquisition circuit 2122 and the current signal collected by the current acquisition circuit 2123 until the preset condition is met, and the controller 214 determines the sum of the electrical signal output by the phase comparator 2121 to the first voltage-controlled oscillator 2124 when the preset condition is met and the preset compensation electrical signal as the target electrical signal corresponding to the target driving frequency.

[0121] As an implementation mode, the preset condition includes that the execution time of the frequency locking operation reaches the preset time. In this implementation mode, the execution time of the frequency locking operation reaches the preset time as the preset condition, and this control method is simple. The preset time can be obtained through multiple experiments and pre-stored in the sample analyzer 10. Of course, in specific applications, the preset time can be designed to be manually adjustable.

[0122] As an implementation mode, when the execution time of the frequency locking operation reaches the preset time, the phase difference between the working current and the working voltage of the ultrasonic transducer 110 is within the first preset range, and the first preset range is that the phase difference between the working voltage and the working current of the ultrasonic device 100 is zero or within a preset range close to zero, which can also indicate that the driving frequency of the ultrasonic device 100 is at the resonant frequency of the ultrasonic device 100 or within a second preset range close to the resonant frequency. When the driving frequency input to the ultrasonic device 100 is the same as the resonant frequency of the dynamic branch of the ultrasonic device 100, the unloaded dynamic branch of the ultrasonic device 100 is purely resistive, and the impedance of the ultrasonic device 100 is the smallest at this time, which is conducive to ensuring that a better ultrasonic mixing effect is achieved in a shorter time.

[0123] As an implementation mode, the waveforms of the working voltage and the working current of the ultrasonic device 100 can be collected to determine whether the phase difference between the working voltage and the working current of the ultrasonic device 100 is zero or within a preset range close to zero. This method is easy to implement.

[0124] As an embodiment, the sample analyzer 10 further includes a sample dispensing device 300, which is used to draw a sample from a sample container and distribute at least part of the drawn sample to a reaction container 30. The sample container is used to load a sample collected from a patient. The reaction container 30 is used to carry the sample for reaction and / or measurement. The sample dispensing device 300 is mainly used to achieve quantitative distribution of the sample.

[0125] As an implementation manner, the sample distributing device 300 is used to draw samples from a sample container located at a sample aspirating position and distribute them to a reaction container 30 located at a sample adding position.

[0126] As an embodiment, the sample dispensing device 300 includes a sample needle, a first motion driving device and a first suction and discharge driving device, wherein the first motion driving device is used to drive the sample needle to move in two-dimensional or three-dimensional space so as to move the sample needle to different positions, such as a standby position, a sample suction position, a sample addition position, a cleaning position, etc. The first suction and discharge driving device is used to drive the sample needle to perform suction and discharge actions.

[0127] As an embodiment, the sample analyzer 10 further includes a reagent dispensing device 400, which is used to absorb reagents from a reagent container and distribute at least part of the absorbed reagents to the reaction container 30. The reagent container is used to store reagents required for the assay. The reagent dispensing device 400 is mainly used to achieve quantitative distribution of reagents.

[0128] As an embodiment, the reagent dispensing device 400 includes a reagent needle, a second motion drive device and a second suction and discharge drive device, and the second motion drive device is used to drive the reagent needle to move in two-dimensional or three-dimensional space, so that the reagent needle moves to different workstations, such as a standby position, a reagent suction position, a reagent addition position, a cleaning position, etc. The second suction and discharge drive device is used to drive the reagent needle to perform suction and discharge actions. It should be noted that the reagent dispensing device 400 may include multiple reagent needles, multiple groups of second motion drive devices and multiple groups of second suction and discharge drive devices, and any two reagent needles can be used to absorb and dispense different types of reagents, respectively, or can be used to absorb and dispense the same type of reagent at different times.

[0129] As an embodiment, the sample analyzer 10 further includes a reagent loading device 600 for storing reagent containers. The reagent dispensing device 400 is used to absorb reagents from the reagent containers on the reagent loading device 600 and distribute at least part of the absorbed reagents into the reaction container 30.

[0130] As an implementation manner, the reagent loading device 600 is in the shape of a disk, and a plurality of reagent positions are formed thereon, and a plurality of reagent containers can be stored simultaneously.

[0131] As an embodiment, the sample analyzer 10 further includes a measuring device 500, which is used to measure the reaction solution made of at least the mixed solution. The measuring device 500 is used to measure the reaction solution in the reaction container 30. The measuring device 500 may be an optical measuring device 500.

[0132] As an embodiment, the sample analyzer 10 further includes an incubation device 700 and a transfer device 800. The incubation device 700 is used to incubate the liquid in the reaction container 30. The transfer device 800 is used to transfer the reaction container 30, for example, to transfer the reaction container 30 after sample addition to the incubation device 700. The reagent dispensing device 400 is used to dispense the reagent into the reaction container 30 located on the incubation device 700. The measuring device 500 is arranged beside the incubation device 700, so as to perform optical measurement on the reaction liquid in the reaction container 30 on the incubation device 700.

[0133] As an embodiment, the incubation device 700 is disc-shaped and has a plurality of incubation holes formed thereon, so that a plurality of reaction containers 30 can be incubated simultaneously.

[0134] As an embodiment, the incubation device 700 is a disc-shaped structure that can drive the reaction container 30 to rotate.

[0135] As an embodiment, the ultrasonic mixing station is located on the incubation device 700. The ultrasonic device 100 is used to ultrasonically mix the target liquid 20 in the reaction container 30 on the incubation device 700. Of course, in a specific application, as an alternative embodiment, the ultrasonic mixing station may not be located on the incubation device 700.

[0136] As an embodiment, the transfer device 800 includes at least one clamping component and at least one third motion driving device for driving the clamping component to move.

[0137] As an embodiment, the sample analyzer 10 also includes a reaction container providing device 900 and a reaction container 30 recovery device, the reaction container providing device 900 is used to provide the reaction container 30, and the reaction container 30 recovery device is used to recover the reaction container 30. The sample analyzer 10 also forms a recovery position, and the reaction container 30 recovery device is located below the recovery position. The transfer device 800 is also used to transfer the reaction container 30 from the incubation device 700 to the recovery position for release and recovery. In this embodiment, the reaction container 30 is a disposable container, that is, a reaction container 30 is recycled after completing a measurement project. Of course, in specific applications, the reaction container 30 can also be a recycled container, that is, the reaction container 30 completes a measurement project, can be cleaned in the sample analyzer 10 and then reused for other measurement projects.

[0138] As an embodiment, the sample analyzer 10 also includes a sample management device 101 and a sample transport device 102. The sample management device 101 is used to place a sample container loaded with a sample to achieve sample loading and storage. The sample transport device 102 is used to transport the sample container output by the sample management device 101 to the sample suction position.

[0139] As an embodiment, the control device 200 includes an ultrasonic control board 210 and a main control board 220, and the ultrasonic control board 210 is used to control the operation of the ultrasonic device 100. The above-mentioned frequency modulation circuit 212, fixed frequency circuit 213, drive circuit 211, controller 214, switching module 215 and electrical signal acquisition circuit 216 are all arranged on the ultrasonic control board 210. The main control board 220 is at least used to control the operation of the ultrasonic control board 210, the sample dispensing device 300, the reagent dispensing device 400 and the measuring device 500. In this embodiment, the ultrasonic control board 210 and the main control board 220 are two independent circuit boards. Of course, in a specific application, as an alternative embodiment, the ultrasonic control board 210 and the main control board 220 can also be integrated into one circuit board.

[0140] In one embodiment, the controller 214 is an MCU.

[0141] As an embodiment, the main control board 220 is also used to control the operation of the incubation device 700 , the transfer device 800 , the magnetic separation device 103 , the reaction container providing device 900 , the sample management device 101 and the sample transport device 102 .

[0142] As an embodiment, the sample is a blood sample, the sample analyzer 10 is an immunoanalyzer, and the sample analyzer 10 also includes a magnetic separation device 103, which is used to magnetically separate the liquid in the reaction container 30. The liquid treated by the magnetic separation device 103 includes a clear liquid and a magnetic bead liquid, the clear liquid is treated as a waste liquid, and the magnetic bead liquid is used to prepare a subsequent reaction liquid. The measurement process of a measurement item in the immunoanalyzer includes: adding a sample, adding a reagent to form a first mixed liquid, mixing and incubating the first mixed liquid to obtain a second mixed liquid, magnetically separating the second mixed liquid to obtain a liquid after magnetic separation, adding a substrate to the liquid after magnetic separation to obtain a third mixed liquid, mixing and incubating the third mixed liquid to obtain a reaction liquid, and optically measuring the reaction liquid. During the magnetic separation process, the operation of adding a separation liquid and mixing will be performed. The above-mentioned mixed liquid as the target liquid 20 includes at least one of the following situations: a first mixed liquid after adding a sample and a reagent and before incubation, a second mixed liquid during the magnetic separation process, and a third mixed liquid formed after the magnetic separation and the addition of a substrate and before incubation. Of course, in a specific application, the type of the sample analyzer 10 is not limited thereto. For example, as an alternative embodiment, the sample analyzer 10 may also be a biochemical analyzer, a blood routine cell analyzer, or a coagulation analyzer.

[0143] The present embodiment also provides a control method for the ultrasonic device 100 in the sample analyzer 10, the control method comprising the following steps: controlling the ultrasonic transducer 110 to drive the ultrasonic vibrator 120 to transmit ultrasonic waves to the reference medium when the ultrasonic transmission end 121 is in contact with the reference medium to perform a frequency locking operation, and obtaining a target electrical signal corresponding to the target driving frequency; controlling the ultrasonic transducer 110 to drive the ultrasonic vibrator 120 to transmit ultrasonic waves to the target liquid 20 when the ultrasonic transmission end 121 is in contact with the target liquid 20 at the target driving frequency, so as to perform ultrasonic mixing on the target liquid 20; wherein the reference medium is a medium whose physical properties and / or composition are different from those of the target liquid 20. In the present embodiment, before the ultrasonic mixing operation, a target electrical signal with the resonant frequency of the current ultrasonic transducer 110 is first obtained in a stable reference medium, and the ultrasonic transducer 110 is driven to operate at the target driving frequency during the ultrasonic mixing operation.

[0144] The specific principles and other implementations of the control method provided in this embodiment are similar to the control principles and implementations described in the above-mentioned sample analyzer 10 and will not be described in detail here.

[0145] This embodiment also provides a computer-readable storage medium, which stores a computer program. When the computer program is executed by a processor (e.g., the controller 214 in the control device 200), the processor implements the steps of the control method of the ultrasonic device 100 in the sample analyzer 10. The computer-readable storage medium may be an internal storage unit of the sample analyzer 10, such as a hard disk or memory of the sample analyzer 10; or, the computer-readable storage medium may be an external storage device of the sample analyzer 10, such as a plug-in hard disk, a smart memory card (Smart Media Card, SMC), a secure digital (Secure Digital, SD) card, a flash card (Flash Card), etc., equipped on the sample analyzer 10.

[0146] This embodiment proposes an economical anti-interference frequency locking solution for application scenarios where the load impedance interference of the ultrasonic device 100 is large. The specific implementation is as follows:

[0147] 1) The driving board of the ultrasonic transducer 110 (i.e., the ultrasonic control board 210 mentioned above) includes a phase-locked loop module (i.e., the frequency modulation circuit 212 mentioned above) for resonant frequency identification and a switch controlled by a digital signal (i.e., the switching module 215 mentioned above). The digital switch can control the first voltage-controlled oscillator 2124 input of the phase-locked loop to switch between the output of the phase comparator 2121 and the output of the DC voltage source.

[0148] 2) Before the ultrasonic vibrator 120 enters the working medium to start ultrasonic mixing, the ultrasonic transducer 110 is first turned on in a stable reference medium (such as air) close to the working medium. At this time, the output end of the phase comparator 2121 is connected to the input end of the first voltage-controlled oscillator 2124, so that the ultrasonic transducer 110 enters a resonant state. The controller 214 records the input voltage V of the first voltage-controlled oscillator 2124 at this time. COin When the ultrasonic vibrator 120 enters the working medium and starts mixing, the controller 214 switches the digital switch so that the DC power supply 2131 is connected to the voltage-controlled oscillator input and controls the output voltage of the DC power supply 2131 to be equal to V Coin (Or it can also be equal to V Coin and the preset compensation voltage).

[0149] 3) When the ultrasonic vibrator 120 starts ultrasonic mixing in the working medium, the load impedance disturbance caused by the ultrasonic mixing of the ultrasonic vibrator 120 will cause the voltage signal output by the phase comparator 2121 to fluctuate, but will not affect the driving frequency of the ultrasonic transducer 110 by the ultrasonic control board 210, so that the ultrasonic transducer 110 always works near the resonant frequency, thereby realizing the anti-interference frequency-locked driving of the ultrasonic transducer 110.

[0150] Embodiment 2:

[0151] The sample analyzer 10 provided in this embodiment is different from that in the first embodiment mainly in that the emphasis is different, which is specifically reflected in that: the first embodiment mainly limits the control scheme that the frequency locking operation and the ultrasonic mixing operation are respectively performed under different medium conditions; while the present embodiment mainly limits the circuit design scheme that the driving circuit 211 of the ultrasonic device 100 can be driven by two circuits respectively.

[0152] Specifically, the sample analyzer 10 provided in this embodiment includes a sample dispensing device 300, a reagent dispensing device 400, an ultrasonic device 100, a measuring device 500 and a control device 200. The sample dispensing device 300 is used to draw a sample from a sample container and distribute at least part of the drawn sample to a reaction container 30; the reagent dispensing device 400 is used to draw a reagent from a reagent container and distribute at least part of the drawn reagent to a reaction container 30. The ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, and the ultrasonic vibrator 120 is used to transmit ultrasonic waves to a target liquid 20 under the drive of the ultrasonic transducer 110, and the target liquid 20 is one of a sample, a reagent, a cleaning liquid and a mixed liquid containing at least a sample and a reagent. The measuring device 500 is used to measure a reaction liquid made of at least a mixed liquid. The control device 200 includes a frequency modulation circuit 212, a fixed frequency circuit 213 and a driving circuit 211. The output end of the driving circuit 211 is connected to the ultrasonic transducer 110 to drive the ultrasonic transducer 110 to work; the output end of the frequency modulation circuit 212 and the output end of the fixed frequency circuit 213 are switchably connected to the input end of the driving circuit 211. The output end of the frequency modulation circuit 212 is used to output a first driving electrical signal to the driving circuit 211 when the ultrasonic device 100 performs a frequency locking operation, and the output end of the fixed frequency circuit 213 is used to output a second driving electrical signal to the driving circuit 211 when the ultrasonic device 100 performs an ultrasonic mixing operation; the input end of the frequency modulation circuit 212 is connected to the ultrasonic transducer 110, and the frequency modulation circuit 212 is used to collect the working electrical signal of the ultrasonic transducer 110 and adjust the first driving electrical signal output to the driving circuit 211 according to the collected working electrical signal. During the frequency locking operation, the first driving electrical signal output by the frequency modulation circuit 212 to the driving circuit 211 is variable. During the ultrasonic mixing operation, the second driving electrical signal outputted from the fixed frequency circuit 213 to the driving circuit 211 will not change. In this embodiment, when the driving circuit 211 performs the frequency locking operation and the ultrasonic mixing operation, the driving circuit 211 provides the driving electrical signal through two different circuits, the frequency modulation circuit 212 and the fixed frequency circuit 213, respectively. In this way, it is beneficial to ensure that the frequency locking operation can achieve frequency modulation, and it is also possible to avoid the disturbance of the target liquid 20 causing the load impedance to interfere with the driving frequency of the ultrasonic device 100 during the ultrasonic mixing operation.

[0153] As an implementation mode, the frequency modulation circuit 212 includes a phase comparator 2121, a first voltage acquisition circuit 2122, a current acquisition circuit 2123 and a first voltage-controlled oscillator 2124, wherein the first voltage acquisition circuit 2122 is connected between the ultrasonic transducer 110 and the first input end of the phase comparator 2121, the current acquisition circuit 2123 is connected between the ultrasonic transducer 110 and the second input end of the phase comparator 2121, and the first voltage-controlled oscillator 2124 is connected between the output end of the phase comparator 2121 and the driving circuit 211; the fixed frequency circuit 213 includes a DC power supply 2131 and a second voltage-controlled oscillator, wherein the input end of the DC power supply 2131 is connected to the controller 214, and the second voltage-controlled oscillator is connected between the output end of the DC power supply 2131 and the driving circuit 211; wherein the first voltage-controlled oscillator 2124 and the second voltage-controlled oscillator are the same voltage-controlled oscillator or two independent voltage-controlled oscillators. The working principles of the frequency modulation circuit 212 and the fixed frequency circuit 213 can be referred to in the first embodiment and will not be described in detail here.

[0154] As an implementation mode, the first voltage-controlled oscillator 2124 and the second voltage-controlled oscillator are the same voltage-controlled oscillator; the control device 200 further includes a switching module 215 and a controller 214, wherein the two input ends of the switching module 215 are respectively connected to the output end of the phase comparator 2121 and the output end of the DC power supply 2131, and the output end of the switching module 215 is connected to the input end of the first voltage-controlled oscillator 2124; the control end of the switching module 215 is connected to the controller 214, and the controller 214 is used to control the switching module 215 to switch between the following working states: connecting the output end of the phase comparator 2121 to the input end of the first voltage-controlled oscillator 2124, and connecting the output end of the DC power supply 2131 to the input end of the first voltage-controlled oscillator 2124. The working principle of the frequency modulation circuit 212 can refer to the first embodiment, and will not be described in detail here.

[0155] As an implementation mode, the control device 200 further includes an electrical signal acquisition circuit 216, and the controller 214 is connected to the output end of the phase comparator 2121 via the electrical signal acquisition circuit 216; the controller 214 is used to: in the process of controlling the ultrasonic device 100 to perform a frequency locking operation, obtain a target electrical signal corresponding to the target driving frequency according to the electrical signal fed back by the electrical signal acquisition circuit 216; the controller 214 is also used to: in the process of controlling the ultrasonic device 100 to perform an ultrasonic mixing operation, control the DC power supply 2131 to output the target electrical signal to the first voltage-controlled oscillator 2124.

[0156] As an implementation mode, a target electrical signal corresponding to a target driving frequency is obtained according to an electrical signal fed back by an electrical signal acquisition circuit 216, including: in a process of controlling an ultrasonic transducer 110 to drive an ultrasonic vibrator 120 to transmit ultrasonic waves to a reference medium to perform a frequency locking operation, a phase comparator 2121 adjusts an electrical signal output to a first voltage-controlled oscillator 2124 according to a phase difference between a voltage signal collected by a first voltage acquisition circuit 2122 and a current signal collected by a current acquisition circuit 2123 until a preset condition is met, and the controller 214 determines the electrical signal output by the phase comparator 2121 to the first voltage-controlled oscillator 2124 when the preset condition is met as a target electrical signal corresponding to the target driving frequency.

[0157] As an implementation manner, the preset condition includes that the execution time of the frequency locking operation reaches a preset time.

[0158] Except for the above differences, other parts of the sample analyzer 10 provided in this embodiment can refer to the first embodiment and will not be described in detail here.

[0159] The above description is only a preferred embodiment of the present invention, and does not limit the patent scope of the present invention. All equivalent structural changes made by using the contents of the present invention specification and drawings under the inventive concept of the present invention, or directly / indirectly applied in other related technical fields are included in the patent protection scope of the present invention.

Claims

1. A sample analyzer, characterized in that: include: A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container; A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container; An ultrasonic device, the ultrasonic device comprising an ultrasonic transducer and an ultrasonic vibrator, the ultrasonic vibrator being used to ultrasonically mix the target liquid under the drive of the ultrasonic transducer, the ultrasonic vibrator having an ultrasonic transmission end away from the ultrasonic transducer, the target liquid being one of the sample, the reagent, and a mixed liquid containing at least the sample and the reagent; a measuring device for measuring a reaction solution made of at least a mixed solution; A control device, wherein the control device is configured to: control the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation when the ultrasonic transmission end is in contact with the reference medium, and obtain a target electrical signal corresponding to a target driving frequency; The control device is further configured to: control the ultrasonic transducer to drive the ultrasonic vibrator at the target driving frequency to transmit ultrasonic waves to the target liquid when the ultrasonic transmission end is in contact with the target liquid, so as to perform ultrasonic mixing on the target liquid; The reference medium is a medium whose physical properties and / or composition are different from those of the target liquid.

2. The sample analyzer according to claim 1, wherein: The control device includes a frequency modulation circuit, a fixed frequency circuit, a drive circuit and a controller; The output end of the driving circuit is connected to the ultrasonic transducer; The output end of the frequency modulation circuit and the output end of the fixed frequency circuit are switchably connected to the input end of the driving circuit, the output end of the frequency modulation circuit is used to output a first driving electrical signal to the driving circuit when the ultrasonic device performs the frequency locking operation, and the output end of the fixed frequency circuit is used to output a second driving electrical signal corresponding to the target electrical signal to the driving circuit when the ultrasonic device performs the ultrasonic mixing operation; The input end of the frequency modulation circuit is connected to the ultrasonic transducer, and the frequency modulation circuit is used to collect the working electrical signal of the ultrasonic transducer and adjust the first driving electrical signal output to the driving circuit according to the collected working electrical signal; The controller is connected to the frequency modulation circuit and the fixed frequency circuit respectively; The controller is configured to: When controlling the ultrasonic device to perform the frequency locking operation, controlling the output end of the frequency modulation circuit to be connected to the input end of the driving circuit, and acquiring the target electrical signal corresponding to the target driving frequency by collecting the electrical signal of the frequency modulation circuit; When controlling the ultrasonic device to perform the ultrasonic mixing operation, the output end of the fixed frequency circuit is controlled to be connected to the input end of the driving circuit, so that the driving circuit drives the ultrasonic transducer to operate under the drive of the second driving electrical signal.

3. The sample analyzer according to claim 2, wherein: The frequency modulation circuit includes a phase comparator, a first voltage acquisition circuit, a current acquisition circuit and a first voltage-controlled oscillator, wherein the first voltage acquisition circuit is connected between the ultrasonic transducer and a first input terminal of the phase comparator, the current acquisition circuit is connected between the ultrasonic transducer and a second input terminal of the phase comparator, and the first voltage-controlled oscillator is connected between an output terminal of the phase comparator and the driving circuit; The fixed frequency circuit includes a DC power supply and a second voltage-controlled oscillator, the input end of the DC power supply is connected to the controller, and the second voltage-controlled oscillator is connected between the output end of the DC power supply and the driving circuit; The first voltage-controlled oscillator and the second voltage-controlled oscillator are the same voltage-controlled oscillator or two independent voltage-controlled oscillators.

4. The sample analyzer according to claim 3, wherein: The first voltage-controlled oscillator and the second voltage-controlled oscillator are the same voltage-controlled oscillator; The control device further comprises a switching module, wherein two input terminals of the switching module are respectively connected to the output terminal of the phase comparator and the output terminal of the DC power supply, the output terminal of the switching module is connected to the input terminal of the first voltage-controlled oscillator, and the control terminal of the switching module is connected to the controller; The controlling the output end of the frequency modulation circuit to be connected to the input end of the driving circuit comprises: controlling the switching module to connect the output end of the phase comparator with the input end of the first voltage-controlled oscillator, so that the output end of the phase comparator is connected to the input end of the driving circuit via the first voltage-controlled oscillator; The controlling the output end of the fixed frequency circuit to be connected to the input end of the driving circuit includes: controlling the switching module to connect the output end of the DC power supply with the input end of the first voltage-controlled oscillator, so that the output end of the DC power supply is connected to the input end of the driving circuit via the first voltage-controlled oscillator.

5. The sample analyzer according to claim 3 or 4, characterized in that: The control device further comprises an electrical signal acquisition circuit, and the controller is connected to the output end of the phase comparator via the electrical signal acquisition circuit; The controller is also configured to: in the process of controlling the ultrasonic device to perform the frequency locking operation, obtain the target electrical signal corresponding to the target driving frequency according to the electrical signal collected by the electrical signal acquisition circuit; in the process of controlling the ultrasonic device to perform the ultrasonic mixing operation, control the DC power supply to output the target electrical signal to the first voltage-controlled oscillator.

6. The sample analyzer according to claim 4, characterized in that: The target electrical signal is a voltage signal; and / or, The switching module is a switch controlled by a digital signal.

7. The sample analyzer according to claim 3 or 4, characterized in that: The controlling of the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation when the ultrasonic transmission end is in contact with the reference medium to obtain a target electrical signal corresponding to a target driving frequency comprises: in the process of controlling the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation, the phase comparator adjusts the electrical signal output to the first voltage-controlled oscillator according to the phase difference between the voltage signal collected by the first voltage collection circuit and the current signal collected by the current collection circuit until a preset condition is satisfied, and the controller determines the electrical signal output by the phase comparator to the first voltage-controlled oscillator when the preset condition is satisfied as the target electrical signal corresponding to the target driving frequency; or, The controlling of the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation when the ultrasonic transmission end is in contact with the reference medium to obtain a target electrical signal corresponding to a target driving frequency includes: in the process of controlling the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation, the phase comparator adjusts the electrical signal output to the first voltage-controlled oscillator according to the phase difference between the voltage signal collected by the first voltage collection circuit and the current signal collected by the current collection circuit until a preset condition is met, and the controller determines the sum of the electrical signal output by the phase comparator to the first voltage-controlled oscillator when the preset condition is met and a preset compensation electrical signal as the target electrical signal corresponding to the target driving frequency.

8. The sample analyzer according to claim 7, wherein: The preset condition includes that the execution time of the frequency locking operation reaches a preset time.

9. The sample analyzer according to any one of claims 1 to 4, characterized in that: The ultrasonic device further includes a driving mechanism, and the control device is further configured to: before controlling the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the target liquid at the target driving frequency to perform ultrasonic mixing on the target liquid, control the driving mechanism to drive the ultrasonic vibrator to move to the ultrasonic mixing position; The control device is further configured to: after controlling the ultrasonic device to perform the frequency locking operation and before controlling the driving mechanism to drive the ultrasonic vibrator to move to the ultrasonic mixing position, control the ultrasonic transducer to turn off; After the ultrasonic vibrator moves to the ultrasonic mixing position, the ultrasonic transducer is controlled to start, and the ultrasonic transducer is driven to work at the target driving frequency to drive the ultrasonic vibrator to ultrasonically mix the target liquid located at the ultrasonic mixing position.

10. The sample analyzer according to any one of claims 1 to 4, characterized in that: The control device is further configured to: before performing ultrasonic mixing on the target liquid in the first sample measurement item of a batch of samples, control the ultrasonic transducer to perform the frequency locking operation; or, The control device is further configured to: before performing ultrasonic mixing on the target liquid in the first sample measurement item after the sample analyzer is turned on, control the ultrasonic transducer to perform the frequency locking operation; or, The control device is further configured to: before performing ultrasonic mixing on the target liquid in the first sample measurement item after the sample analyzer is restarted from standby, control the ultrasonic transducer to perform the frequency locking operation; or, The control device is further configured to: control the ultrasonic transducer to perform the frequency locking operation before performing ultrasonic mixing on the target liquid in the first sample measurement item after the sample analyzer is restarted after maintenance; or, The control device is further configured to control the ultrasonic transducer to perform the frequency locking operation before performing the ultrasonic mixing operation on the target liquid in each of the sample measurement items.

11. The sample analyzer according to any one of claims 1 to 4, characterized in that: The reference medium is air, and the ultrasonic transmission end is in contact with the reference medium when the ultrasonic vibrator is unloaded; or The reference medium is a reference solid, and the situation in which the ultrasonic transmission end contacts the reference medium is the situation in which the ultrasonic transmission end contacts the reference solid; or, The reference medium is a reference liquid with known physical properties and / or known components, and the situation in which the ultrasonic transmission end contacts the reference medium is a situation in which the ultrasonic transmission end is inserted into the reference liquid.

12. A sample analyzer, characterized in that: include: A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container; A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container; An ultrasonic device, the ultrasonic device comprising an ultrasonic transducer and an ultrasonic vibrator, the ultrasonic vibrator being used to transmit ultrasonic waves to the target liquid under the drive of the ultrasonic transducer, the target liquid being one of the sample, the reagent, a cleaning liquid, and a mixed liquid containing at least the sample and the reagent; a measuring device for measuring a reaction solution made of at least a mixed solution; A control device, the control device comprising a frequency modulation circuit, a fixed frequency circuit and a drive circuit, wherein an output end of the drive circuit is connected to the ultrasonic transducer to drive the ultrasonic transducer to work; The output end of the frequency modulation circuit and the output end of the fixed frequency circuit are switchably connected to the input end of the driving circuit, the output end of the frequency modulation circuit is used to output a first driving electrical signal to the driving circuit when the ultrasonic device performs a frequency locking operation, and the output end of the fixed frequency circuit is used to output a second driving electrical signal to the driving circuit when the ultrasonic device performs an ultrasonic mixing operation; The input end of the frequency modulation circuit is connected to the ultrasonic transducer, and the frequency modulation circuit is used to collect the working electrical signal of the ultrasonic transducer and adjust the first driving electrical signal output to the driving circuit according to the collected working electrical signal.

13. The sample analyzer according to claim 12, wherein: The frequency modulation circuit includes a phase comparator, a first voltage acquisition circuit, a current acquisition circuit and a first voltage-controlled oscillator, wherein the first voltage acquisition circuit is connected between the ultrasonic transducer and a first input terminal of the phase comparator, the current acquisition circuit is connected between the ultrasonic transducer and a second input terminal of the phase comparator, and the first voltage-controlled oscillator is connected between an output terminal of the phase comparator and the driving circuit; The fixed frequency circuit includes a DC power supply and a second voltage-controlled oscillator, the input end of the DC power supply is connected to the controller, and the second voltage-controlled oscillator is connected between the output end of the DC power supply and the driving circuit; The first voltage-controlled oscillator and the second voltage-controlled oscillator are the same voltage-controlled oscillator or two independent voltage-controlled oscillators.

14. The sample analyzer according to claim 13, wherein: The first voltage-controlled oscillator and the second voltage-controlled oscillator are the same voltage-controlled oscillator; The control device further comprises a switching module and a controller, wherein two input ends of the switching module are respectively connected to the output end of the phase comparator and the output end of the DC power supply, and the output end of the switching module is connected to the input end of the first voltage-controlled oscillator; The control end of the switching module is connected to the controller, and the controller is used to control the switching module to switch between the following working states: connecting the output end of the phase comparator with the input end of the first voltage-controlled oscillator, and connecting the output end of the DC power supply with the input end of the first voltage-controlled oscillator.

15. The sample analyzer according to claim 14, characterized in that: The control device further comprises an electrical signal acquisition circuit, and the controller is connected to the output end of the phase comparator via the electrical signal acquisition circuit; The controller is used to: in the process of controlling the ultrasonic device to perform the frequency locking operation, obtain a target electrical signal corresponding to the target driving frequency according to the electrical signal fed back by the electrical signal acquisition circuit; The controller is also used to: control the DC power supply to output the target electrical signal to the first voltage-controlled oscillator during the process of controlling the ultrasonic device to perform the ultrasonic mixing operation.

16. The sample analyzer according to claim 15, characterized in that: The step of obtaining a target electrical signal corresponding to a target driving frequency according to the electrical signal fed back by the electrical signal acquisition circuit comprises: in the process of controlling the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation, the phase comparator adjusts the electrical signal output to the first voltage-controlled oscillator according to the phase difference between the voltage signal acquired by the first voltage acquisition circuit and the current signal acquired by the current acquisition circuit until a preset condition is satisfied, and the controller determines the electrical signal output by the phase comparator to the first voltage-controlled oscillator when the preset condition is satisfied as the target electrical signal corresponding to the target driving frequency, wherein the preset condition comprises that the execution time of the frequency locking operation reaches a preset time; or, The target electrical signal corresponding to the target driving frequency is obtained according to the electrical signal fed back by the electrical signal acquisition circuit, comprising: in the process of controlling the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium to perform a frequency locking operation, the phase comparator adjusts the electrical signal output to the first voltage-controlled oscillator according to the phase difference between the voltage signal collected by the first voltage acquisition circuit and the current signal collected by the current acquisition circuit until a preset condition is met, and the controller determines the sum of the electrical signal output by the phase comparator to the first voltage-controlled oscillator when the preset condition is met and a preset compensation electrical signal as the target electrical signal corresponding to the target driving frequency, wherein the preset condition includes that the execution time of the frequency locking operation reaches a preset time.

17. A method for controlling an ultrasonic device in a sample analyzer, characterized in that: The steps include: Controlling the ultrasonic transducer to drive the ultrasonic vibrator to transmit ultrasonic waves to the reference medium when the ultrasonic transmission end is in contact with the reference medium to perform a frequency locking operation, thereby obtaining a target electrical signal corresponding to a target driving frequency; Controlling the ultrasonic transducer to drive the ultrasonic vibrator at the target driving frequency to transmit ultrasonic waves to the target liquid when the ultrasonic transmission end is in contact with the target liquid, so as to perform ultrasonic mixing on the target liquid; The reference medium is a medium whose physical properties and / or composition are different from those of the target liquid.

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