Odorless DHA small drop pill and preparation method thereof

Abstract

The present invention provides odorless DHA small dropping pills and a preparation method thereof, comprising: a capsule skin, which is prepared from a gelatin solution comprising gelatin, glycerin and water, wherein the capsule skin has a frosted appearance, wherein the gelatin comprises a mixture of pigskin gelatin and fishskin gelatin; and contents wrapped in the capsule skin, which comprise oil and fat and N-acetylneuraminic acid, wherein the oil and fat at least comprises DHA algae oil. The DHA small dropping pills prepared by this solution are not easily oxidized and deteriorated under light, have no odor, and are not easily adhered under high temperature or high humidity.

Description

Technical Field

[0001] The present invention relates to the field of dripping pills, and in particular to a DHA dripping pill without fishy smell and a preparation method thereof. Background Art

[0002] DHA plays an important role in the central nervous system, cardiovascular system, and visual nervous system. Supplementation is particularly crucial during infancy and childhood. Small, drop-shaped gel candies are popular with consumers due to their fun, popping sensation, thin coating, and ease of chewing and dissolving. They are widely used in the DHA nutritional supplement market.

[0003] DHA is an important ω-3 long-chain polyunsaturated fatty acid with a high degree of unsaturation, which presents some challenges in terms of stability. For example, under conditions of light, high temperature, and high humidity, DHA oils are prone to oxidation, such as increased fishy and rancid odors, and increased peroxide and acid values, which can reduce product stability and shelf life.

[0004] Compared with transparent DHA small pills, small pills with a frosted appearance have better light-shielding, antioxidant and anti-adhesion properties. However, the current frosting process for DHA small pills is achieved by adding modified starch or sugar alcohols to the capsule skin to change the surface properties of the rubber. This process requires precise control of the type, amount and addition method of the added substances. The operation process is relatively complicated and requires the introduction of other auxiliary materials besides nutrients and basic rubber components. It does not meet the requirements of clean labels, thereby limiting the application of frosting. Summary of the Invention

[0005] The object of the present invention is to provide a DHA small drop pill without fishy smell and a preparation method thereof, wherein oil and N-acetylneuraminic acid are mixed to obtain the contents and the ratio of gelatin in the capsule is adjusted to obtain DHA small drop pill without fishy smell with high process feasibility and stability.

[0006] To achieve the above objectives, the present technical solution provides an odorless DHA small drop pill and a preparation method thereof, comprising:

[0007] A capsule skin, the capsule skin being prepared from a gelatin solution comprising gelatin, glycerin and water, wherein the gelatin comprises a mixture of pig skin gelatin and fish skin gelatin, wherein the capsule skin has a frosted appearance;

[0008] The contents wrapped in the capsule skin include oil and N-acetylneuraminic acid, wherein the oil at least includes DHA algae oil.

[0009] This solution aims to solve the problems existing in the process and performance of existing DHA small drop pills, and to provide an odorless DHA small drop pill that can achieve good nutritional supplementation, a stable frosting effect, and meet clean label requirements, and a preparation method thereof. Through innovative formula design and process optimization, it overcomes the defect that the traditional frosting process requires the introduction of a large number of non-nutritional excipients, and improves the overall quality and market competitiveness of the product. Specifically, unlike traditional DHA small drop pills, this solution adds N-acetylneuraminic acid to the contents. The addition of N-acetylneuraminic acid can not only increase the formation of synapses and promote functions such as the release of neurotransmitters, thereby providing nutritional benefits in combination with DHA supplementation; and N-acetylneuraminic acid can migrate to the capsule skin to form a frosted capsule skin, and is combined with a gelatin solution to form a stable frosted capsule skin, thereby reducing the use of non-nutritional materials.

[0010] In some embodiments, the oil includes one or more of plant-derived oils, animal-derived oils, and microbial-derived oils other than DHA algae oil, wherein the plant-derived oil is selected from one or more combinations of walnut oil, flaxseed oil, and MCT oil, the animal-derived oil is selected from fish oil containing DHA and EPA, and the microbial-derived oil is selected from ARA oil fermented by microorganisms, wherein MCT oil refers to medium-chain triglycerides.

[0011] It should be noted that this program aims to provide an odorless DHA small drop pill that mainly provides DHA nutrients. Walnut oil in plant-derived oils is also rich in unsaturated fatty acids essential to the human body, such as linolenic acid and linoleic acid. Flaxseed oil can be partially converted into DHA in the human body to cooperate with DHA algae oil to improve the body's absorption and utilization efficiency of DHA. MCT oil is particularly suitable for infants and other people whose digestive systems are not fully developed; EPA in animal-derived oils can work together with DHA to protect the human cardiovascular system and nervous system; microbial-derived oils combined with DHA can simulate the fatty acid composition in breast milk to provide comprehensive and balanced nutritional support for infants and young children.

[0012] In some embodiments, the contents of the odorless DHA small drop pills include a flavoring selected from one or more combinations of lemon oil and sweet orange oil. Lemon oil is selected as the flavoring to impart a distinct lemon flavor to the DHA small drop pills, effectively masking the fishy smell of the DHA algae oil and improving the overall odor of the product. Lemon oil also has certain antioxidant properties, enhancing the antioxidant capacity of the DHA small drop pills. Orange oil is selected as the flavoring to impart a sweet citrus flavor to the DHA small drop pills, enhancing their taste.

[0013] To allow N-acetylneuraminic acid to migrate into the bladder skin, creating a frosted, "sand-returning" effect, this solution sets the ratio of N-acetylneuraminic acid to gelatin at 1:20 to 1:40. Specifically, N-acetylneuraminic acid coexists with ingredients such as oil in the contents. N-acetylneuraminic acid is water-soluble, and once the bladder skin is formed, it migrates from the contents to the bladder skin due to the influence of the bladder skin's moisture and environmental conditions. Gelatin molecules have a specific spatial structure and charge distribution, which allows them to interact with N-acetylneuraminic acid molecules. When N-acetylneuraminic acid migrates to the bladder skin, it binds to the gelatin molecules and gradually aggregates, eventually forming tiny crystalline particles that precipitate on the bladder skin surface, creating a frosted effect.

[0014] When the ratio of N-acetylneuraminic acid to gelatin is 1:40, which is the minimum threshold for achieving a "sand-returning" effect. At this ratio, a sufficient number of N-acetylneuraminic acid molecules can interact with gelatin molecules and migrate to the capsule skin. As the N-acetylneuraminic acid ratio increases, more molecules can participate in the "sand-returning" process, and the frosting effect will gradually become more obvious. However, if the N-acetylneuraminic acid ratio is too high, it can also lead to some problems. On the one hand, excessive N-acetylneuraminic acid can change the physical and chemical properties of the capsule skin, such as destroying the gel strength and viscosity of gelatin, which in turn affects droplet formation during the dripping process and the capsule skin's wrapping effect. On the other hand, excessive N-acetylneuraminic acid precipitation on the capsule skin may lead to excessive frosting, affecting the capsule skin's integrity and mechanical properties, making the capsule skin fragile and prone to rupture during processing, storage, or transportation.

[0015] In addition, to further improve the problem of unstable rubber production caused by N-acetylneuraminic acid, this solution sets the mass ratio of fish skin gelatin to pig skin gelatin in the gelatin to be 0.1 to 1:1. Preferably, the mass ratio of fish skin gelatin to pig skin gelatin in the gelatin is 0.5:1.

[0016] Specifically, pigskin gelatin has a relatively low viscosity and good formability. Its relatively regular molecular chain structure provides a stable foundation for the capsule skin, helping to form a uniform capsule shape during the dripping process. Fish skin gelatin, on the other hand, has a higher viscosity and contains more hydrophobic groups in its molecular chain. This enhances intermolecular interactions when mixed with pigskin gelatin, forming a tighter network structure. This network structure better locks in moisture, reduces interaction with N-acetylneuraminic acid, and enables the capsule skin to withstand certain external forces without rupturing, thus maintaining the stability of the colloid.

[0017] Furthermore, this protocol sets a mass ratio of fish skin gelatin to pig skin gelatin within a range of 0.1 to 1:1, allowing the high viscosity of fish skin gelatin to compensate for the potential structural loosening of pig skin gelatin when interacting with N-acetylneuraminic acid. For example, the acidity of N-acetylneuraminic acid can affect interactions such as hydrogen bonding between gelatin molecules, causing the capsule to soften, deform, or become difficult to form. However, an appropriate amount of fish skin gelatin can enhance these interactions and maintain the mechanical strength and stability of the capsule.

[0018] In some embodiments, the gelatin solution contains a sweetening substance, wherein the sweetening substance is selected from one or more of sorbitol, xylitol, erythritol, mogroside, and steviol glycoside. The addition of the sweetening substance can further improve the taste of the odorless DHA small drop pills.

[0019] In some embodiments, the odorless DHA pellets include:

[0020] The capsule skin is prepared from a gelatin solution comprising 60 to 180 parts by mass of gelatin, 20 to 60 parts by mass of glycerin, and 90 to 110 parts by mass of water, wherein the gelatin comprises 60 to 120 parts by mass of pigskin gelatin and 1 to 60 parts by mass of fishskin gelatin;

[0021] The contents wrapped in the capsule skin include oil and N-acetylneuraminic acid in a mass ratio of 2 to 10, wherein the oil at least includes DHA algae oil in a mass ratio of 70 to 98.

[0022] In a specific embodiment, the odorless DHA pellets include:

[0023] The capsule skin is prepared from a gelatin solution comprising 120 parts by mass of gelatin, 24 parts by mass of glycerin, and 100 parts by mass of water, wherein the gelatin comprises 80 parts by mass of pigskin gelatin and 40 parts by mass of fishskin gelatin;

[0024] The contents wrapped in the capsule skin include oil and N-acetylneuraminic acid in a mass ratio of 5 parts, wherein the oil includes at least 85 parts of DHA algae oil.

[0025] It should be noted that "parts by mass" refers to the basic unit of measurement for the mass ratio of multiple components, and 1 part can represent any unit of mass. In this solution, "a gelatin solution prepared by a mass ratio of 120 parts gelatin, 24 parts glycerin, and 100 parts water" refers to a gelatin:glycerin:water mass ratio of 120:24:100. Unlike the mass ratio, the mass ratio of all components is not limited to 100 parts.

[0026] In a second aspect, the present technical solution provides a method for preparing odorless DHA small drop pills, comprising the following steps:

[0027] Pour the oil and N-acetylneuraminic acid into an emulsifying tank and stir to mix uniformly to obtain the contents, wherein the oil at least includes DHA algae oil;

[0028] Pour water into a gelling tank and set a high temperature environment, add glycerin and gelatin into the gelling tank in sequence, and stir the gelling until the gelatin is completely dissolved to obtain a transparent colloidal solution, wherein the gelatin includes pig skin gelatin and fish skin gelatin;

[0029] Pour the gelatin solution and the contents into a coaxial double-nozzle dropping pill making device and extrude the dropping pills, wherein the gelatin solution is ejected from the outer nozzle of the coaxial double-nozzle dropping pill making device, and the contents are ejected from the inner nozzle of the coaxial double-nozzle dropping pill making device, and the temperature of the contents is lower than the temperature of the gelatin solution;

[0030] After the pellets are shaped and dried, odorless DHA pellets with a frosted appearance are obtained.

[0031] As mentioned above, in some embodiments, the oil includes one or more of plant-derived oils, animal-derived oils, and microbial-derived oils other than DHA algae oil, wherein the plant-derived oil is selected from one or more combinations of walnut oil, flaxseed oil, and MCT oil, the animal-derived oil is selected from fish oil containing DHA and EPA, and the microbial-derived oil is selected from ARA oil fermented by microorganisms.

[0032] In some embodiments, the contents of the odorless DHA pellets include flavoring substances, wherein the flavoring substances are selected from one or more combinations of lemon oil and sweet orange oil. At this time, the oil, flavoring substances and N-acetylneuraminic acid are poured into an emulsifying tank and stirred and mixed evenly to obtain the contents.

[0033] In some embodiments, the ratio of N-acetylneuraminic acid to gelatin is set to 1:20 to 1:40.

[0034] In some embodiments, the mass ratio of fish skin gelatin to pig skin gelatin in the gelatin is 0.1:1 to 1:1.

[0035] In some embodiments, the gelatin solution contains a sweetening substance, wherein the sweetening substance is selected from one or more of sorbitol, xylitol, erythritol, mogroside, and steviol glycoside. At this time, water is poured into a gelatinization tank and a high temperature environment is set. Glycerin, the sweetening substance, and gelatin are added to the gelatinization tank in sequence, and the gelatinization is stirred until the gelatin is completely dissolved to obtain a transparent colloidal solution.

[0036] Regarding the preparation process, in some embodiments, this solution pours grease and N-acetylneuraminic acid into an emulsifying tank, sets the stirring speed to 30-40 Hz, stirs for 20-30 minutes, and simultaneously starts vacuuming, sets the vacuum degree to -0.5-0.1 MPa, and stirs and mixes to obtain the contents. This solution can also achieve uniform distribution of grease and N-acetylneuraminic acid over a long period of time (such as 30 minutes) by setting a lower stirring speed (such as 30 Hz). In addition, the vacuuming operation can make the contents more closely mixed under a negative pressure environment, and can also prevent grease oxidation.

[0037] Preferably, the oil and N-acetylneuraminic acid are poured into an emulsifying tank, the stirring speed is set to 35 Hz, the mixture is stirred for 20 minutes, vacuuming is started simultaneously, the vacuum degree is set to -0.1 MPa, and the mixture is stirred and mixed to obtain the contents.

[0038] In some embodiments, water is poured into a gelling tank and the high temperature is set to 80°C to 85°C. Glycerin and gelatin are added to the gelling tank in sequence and stirred. The stirring speed is set to 40 to 50 Hz. The gelling tank is stirred until the gelatin is completely dissolved to obtain a colloidal solution. After vacuum degassing, the solution is placed at 80°C to 85°C for insulation. It should be noted that when the colloidal solution is clear and transparent, the gelatin is considered to be completely dissolved. This solution dissolves gelatin at a temperature of 80°C to 85°C, which can make the colloidal solution formed by gelatin, water and glycerin have good fluidity and stability, so that it can pass through the nozzle smoothly during dripping to form a uniform capsule skin.

[0039] Preferably, water is poured into a gelling tank and the high temperature is set to 80°C. Glycerin and gelatin are added to the gelling tank in sequence and stirred. The stirring speed is set to 45HZ. The gelling tank is stirred until the gelatin is completely dissolved to obtain a transparent colloidal solution. After vacuum degassing, it is placed at 80°C for insulation.

[0040] In some embodiments, the pig skin gelatin has a freezing force of 250 and a viscosity of 4.2 mPa.s; the fish skin gelatin has a freezing force of 200 and a viscosity of 8.48 mPa.s.

[0041] In some embodiments, the coaxial double-nozzle drop-pill making device of the present embodiment includes a coaxially arranged internal nozzle and external nozzle, wherein the gelatin solution is ejected from the external nozzle of the coaxial double-nozzle drop-pill making device, and the contents are ejected from the internal nozzle of the coaxial double-nozzle drop-pill making device, and the contents and the gelatin solution are extruded simultaneously to form a double-layer structured drop-pill.

[0042] In some embodiments, the temperature of the contents is set at 40°C and the temperature of the gelatin solution is set at 85°C.

[0043] Regarding the shaping and drying of the dropping pills, in some specific embodiments, the dropping pills are immersed in caprylic and capric glycerides and refrigerated at 4°C for 3 hours to set the shape. The deoiled dropping pills are slowly placed in a rotating cage, a piece of oil-absorbing cotton is added, the feeding port and the wind shield are closed, and the drying conditions are temperature ≤ 25°C, humidity ≤ 65, and drying for 6 hours to make the moisture content of the rubber less than 15%.

[0044] In some embodiments, after obtaining the odorless DHA pellets, they are screened with a sieve of a specific size and then packaged. The specific sieve size is adjusted according to actual process requirements. In the embodiment of this solution, the sieve size is 6.0±0.5mm. The specific inner packaging process is also adjusted according to actual process requirements. An eight-row counting and packaging machine is used for nitrogen packaging, and the oxygen content in the strip bag is required to be less than 2%.

[0045] Compared with the existing technology, this technical solution has the following characteristics and beneficial effects:

[0046] The odorless DHA pellets provided by this solution combine oil and N-acetylneuraminic acid, which together promote brain development, fully meeting the needs of different populations and leveraging the synergistic effects of multiple nutrients. The precise ratio of N-acetylneuraminic acid to gelatin creates a frosted capsule that is stable and requires no additional non-nutritional excipients, ensuring clean label compliance. Furthermore, pigskin gelatin and fish skin gelatin are blended in a specific mass ratio to improve the stability of the gelatin process and enhance the performance of the capsule, significantly increasing the DHA content and flavor stability. Furthermore, the odorless DHA pellets prepared in this solution are resistant to oxidation and deterioration under light, have no fishy smell, and are non-sticky even in high temperatures or humidity. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] Figure 1 These are appearance observation pictures of commercially available sample A and comparative examples 1 to 4.

[0048] Figure 2 Schematic diagram of the non-adhesive state of Example 1 and the adhesive state and the separated state after adhesion of Comparative Example 8. DETAILED DESCRIPTION

[0049] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention are within the scope of protection of the present invention.

[0050] Experimental group design:

[0051] Example 1 Odorless DHA small drop pills and preparation method thereof:

[0052] (1) Preparation of contents: Weigh 85 parts of DHA algae oil and 5 parts of N-acetylneuraminic acid according to the formula and pour them into an emulsifier. Stir at 35 Hz for more than 20 minutes. Simultaneously start vacuuming and set the vacuum to -0.1 MPa. Mix well and set aside.

[0053] (2) Preparation of gelatin solution: Weigh 100 parts of water and pour it into a gelatinization tank, and set the temperature of the gelatinization tank to 80°C; then pour 24 parts of glycerin into the gelatinization tank, and finally pour 80 parts of pig skin gelatin (freezing force 250, viscosity: 4.2mPa.s) and 40 parts of fish skin gelatin (freezing force 200, viscosity: 8.48mPa.s), set the stirring tank speed to 45HZ, stir the gelatinization until the gelatin is completely dissolved and the glue solution is clear and transparent, vacuum degassing, and keep warm at 80°C for use.

[0054] (3) Dropping: Using an inner nozzle and an outer nozzle with increasing diameters at the same center (both are coaxial nozzles), the solution of the small droplet contents is extruded from the inner nozzle, and the solution of the small droplet capsule is extruded from the outer nozzle at the same time to form a double-layer structure composite material. The temperature of the rubber liquid is controlled at 85°C and the temperature of the core liquid is controlled at 40°C.

[0055] (4) Shaping: Immerse the prepared balls in caprylic and capric glycerides and refrigerate at 4°C for 3 h to set;

[0056] (5) Drying: Slowly place the degreased pellets into a rotating cage, add a piece of oil-absorbing cotton, close the feeding port and the wind shield, and dry under the conditions of temperature ≤ 25 ° C, humidity ≤ 65, and dry for 6 hours until the moisture content of the rubber is less than 15%;

[0057] (6) Screening: Use a sieve specified for the particle size of the pellets (6.0 ± 0.5 mm) to screen each plate of pellets to obtain odorless DHA pellets with a frosted appearance.

[0058] (7) Inner packaging: Use an eight-row filling and packaging machine for nitrogen packaging, and the oxygen content in the bag must be less than 2%.

[0059] The ingredients of the odorless DHA small dropping pills prepared in Example 1 are shown in Table 1 below:

[0060] Table 1 Ingredients of odorless DHA small drop pills

[0061]

[0062] Example 2:

[0063] The process is the same as that of Example 1, except that 5 parts of sweet orange oil and 5 parts of erythritol are added to the contents and the capsule skin, respectively.

[0064] Comparative Example 1

[0065] The process is the same as that of Example 1. The main difference is that 3 parts of N-acetylneuraminic acid are added when the contents are prepared, and 120 parts of pigskin gelatin (jelly strength 250, viscosity: 4.2 mPa·s) are added when the capsule is prepared.

[0066] Comparative Example 2

[0067] The process is the same as that of Example 1. The main difference is that 4 parts of N-acetylneuraminic acid are added when the contents are prepared, and 120 parts of pigskin gelatin (jelly strength 250, viscosity: 4.2 mPa·s) are added when the capsule is prepared.

[0068] Comparative Example 3

[0069] The process is the same as that of Example 1. The main difference is that 5 parts of N-acetylneuraminic acid are added when the contents are prepared, and 120 parts of pigskin gelatin (jelly strength 250, viscosity: 4.2 mPa·s) are added when the capsule is prepared.

[0070] Comparative Example 4

[0071] The process is the same as that of Example 1. The main difference is that 6 parts of N-acetylneuraminic acid are added when the contents are prepared, and 120 parts of pigskin gelatin (jelly strength 250, viscosity: 4.2 mPa·s) are added when the capsule is prepared.

[0072] Comparative Example 5

[0073] The process is the same as that of Example 1. The main difference is that 103 parts of pig skin gelatin (freezing strength 250, viscosity: 4.2 mPa.s) and 17 parts of fish skin gelatin (freezing strength 200, viscosity: 8.48 mPa.s) are added during the preparation of the capsule skin.

[0074] Comparative Example 6

[0075] The process is the same as that of Example 1. The main difference is that 96 parts of pig skin gelatin (jelly strength 250, viscosity: 4.2 mPa.s) and 24 parts of fish skin gelatin (jelly strength 200, viscosity: 8.48 mPa.s) are added during the preparation of the capsule skin.

[0076] Comparative Example 7

[0077] The process is the same as that of Example 1. The main difference is that 60 parts of pig skin gelatin (freezing force 250, viscosity: 4.2 mPa.s) and 60 parts of fish skin gelatin (freezing force 200, viscosity: 8.48 mPa.s) are added during the preparation of the capsule skin.

[0078] Performance testing:

[0079] Appearance observation: Place on a white background and observe under natural light.

[0080] Drop test of the pills: 8 DHA small pills were randomly selected from each group of examples or comparative examples, and the DHA small pills were allowed to fall freely from a height of 10 cm on a smooth test bench. The ones without cracks passed the test.

[0081] Sensory evaluation: 30 selected sensory evaluators were selected to evaluate their preferences with reference to the preference rating table in Table 2, and to describe their reasons:

[0082] Table 2 Preference rating table

[0083] Score Preferences 0 I really don't like it 1 dislike 2 A little dislike 3 It doesn't matter 4 I like it a little bit 5 like 6 Like it very much .

[0084] Strong light irradiation: Use the standardized equipment "adjustable light box" and set the light intensity to 4500lx±500lx. All samples are placed naked and irradiated with strong light.

[0085] The DHA small dripping pills of Comparative Examples 1 to 4 were subjected to appearance observation, drop test and sensory evaluation, and the test data were shown in Table 3 below:

[0086] Table 3 Drop test and sensory evaluation test data

[0087]

[0088] The product pictures of commercially available sample A (transparent small drop pills, domestically produced) and the DHA small drop pills obtained in Comparative Examples 1, 2, 3 and 4 and their preparation methods are shown in the figure. Figure 1 shown.

[0089] According to the results of Comparative Examples 1-4, as the amount of N-acetylneuraminic acid increases, the frosting becomes more and more obvious. When the amount is increased to 6%, the taste is unacceptable due to the acidity of the material, and local excessive frosting occurs, affecting the appearance. While 4% N-acetylneuraminic acid can meet the frosting effect and taste requirements, the yield is low. This may be because its low pH value destroys the interaction between gel molecules, resulting in the collapse of the gel structure. Further optimization of the rubber is needed.

[0090] The DHA small dripping pills of Example 1, Example 2, and Comparative Examples 5 to 7 were subjected to appearance observation, drop test, and sensory evaluation to obtain test data as shown in Table 4 below:

[0091] Table 4 Drop test and photosensitivity evaluation test data

[0092]

[0093] According to Example 1 and Comparative Examples 5-7, the yield of small drop pills can be improved with increasing the amount of fish skin gelatin added. This may be because the viscosity of fish skin gelatin is much higher than that of pig skin gelatin, making it easier to form a network structure: after dissolving in water, the gelatin particles can attract and intertwine with each other, forming a layered network structure. This easier water-locking property can completely fill the gaps in the gel, reducing the binding with water-soluble acidic raw materials and thus protecting the colloid. However, when the fish skin gelatin dosage is increased to 1:1, the glue power is insufficient, the tensile strength and elasticity deteriorate, the hardness of the pills is insufficient, and the drop resistance test fails to meet the standard. The fish skin gelatin and pig skin gelatin have the highest yield at 0.5:1.

[0094] From the comparison results of Example 2 and Example 1, it can be seen that the addition of the flavoring substance sweet orange oil and the seasoning substance erythritol to the formula enhances the flavor of the product and significantly increases the preference.

[0095] The results of the changes in the indicators of the DHA small drop pills obtained after strong light irradiation of the samples of Example 1, Comparative Examples 1 to Comparative Examples 4 and Comparative Example 8 are shown in Table 5 below:

[0096] Table 5. Changes in the indicators of DHA small drop pills irradiated with strong light

[0097]

[0098]

[0099] Note: Comparative Example 8 is a domestically produced frosted small pellet purchased.

[0100] It should be noted that the lower the peroxide value and anisidine value, the lower the degree of oxidation of the algae oil. The standards are: anisidine value ≤15, peroxide value ≤0.25g / 100g, and acid value (KOH) ≤3mg / g.

[0101] Based on the flavor and physicochemical index results of Example 1, Comparative Examples 1 to 4, and Comparative Example 8, it can be concluded that scrubbing the capsule skin can reduce the oxidation of the fat in the contents to a certain extent, indicating that scrubbing can effectively prevent light penetration and also have an antioxidant effect. The DHA small drop pills of Example 1 showed good antioxidant properties and were slightly better than those of Comparative Examples 3, 4, and commercially available samples. This may be related to the improved airtightness of the fish skin gelatin.

[0102] In addition, the adhesion degree of Example 1, Comparative Examples 1 to 4, and Comparative Example 8 was tested at different temperatures and humidities. The results of the rubber adhesion of the DHA small droplets at different temperatures are shown in Table 6 below, and the results of the rubber adhesion of the DHA small droplets at different humidities are shown in Table 7 below:

[0103] Table 6 DHA small pills rubber adhesion results at different temperatures

[0104]

[0105]

[0106] According to the adhesion conditions of Example 1 and Comparative Examples 1 to 4 and Comparative Example 8, it can be concluded that capsule skin frosting can improve the temperature resistance of DHA small droplets. The DHA small droplets frosted with N-acetylneuraminic acid show good temperature resistance and are slightly better than commercially available samples.

[0107] Table 7 DHA small pills rubber adhesion results at different humidity

[0108]

[0109] According to the adhesion results of Example 1 and Comparative Examples 1 to 4 and Comparative Example 8, it can be concluded that scrubbing the capsule skin can improve the moisture resistance of the DHA small droplets. The DHA small droplets scrubbed with N-acetylneuraminic acid showed good moisture resistance and slightly better than the commercially available samples. The solution of Comparative Example 8 adhered at 75% RH, and the appearance was concave after separation. Figure 2 shown.

[0110] It is to be understood that the term "one" should be understood as "at least one" or "one or more", that is, in one embodiment, the number of an element may be one, while in another embodiment, the number of the elements may be multiple, and the term "one" should not be understood as a limitation on the quantity.

[0111] The present invention is not limited to the above-mentioned optimal implementation mode. Anyone can derive other forms of products under the inspiration of the present invention. However, no matter what changes are made in the shape or structure, any technical solution that is the same or similar to that of the present application falls within the scope of protection of the present invention.

Claims

1. A DHA small drop pill without fishy smell, characterized in that: include: A capsule skin, the capsule skin being prepared from a gelatin solution comprising gelatin, glycerin and water, wherein the gelatin comprises a mixture of pig skin gelatin and fish skin gelatin, wherein the capsule skin has a frosted appearance; The contents wrapped in the capsule skin include oil and N-acetylneuraminic acid, wherein the oil at least includes DHA algae oil, the ratio of N-acetylneuraminic acid to gelatin is 1:20-1:40, and the mass ratio of fish skin gelatin to pig skin gelatin in the gelatin is 0.1:1-1:

1.

2. The odorless DHA small dripping pill according to claim 1, characterized in that: The capsule skin is prepared from a gelatin solution comprising 60-180 parts by mass of gelatin, 20-60 parts by mass of glycerol, and 90-110 parts by mass of water, wherein the gelatin contains 60-120 parts by mass of pigskin gelatin and 1-60 parts by mass of fishskin gelatin; the contents include oil and fat and 2-10 parts by mass of N-acetylneuraminic acid, wherein the oil and fat at least include 70-98 parts by mass of DHA algae oil.

3. The odorless DHA small dripping pill according to claim 1, characterized in that: The gelatin solution contains sweeteners, wherein the sweeteners are selected from one or more of sorbitol, xylitol, erythritol, mogroside, and steviol glycoside; the contents include flavorings, wherein the flavorings are selected from one or more combinations of lemon oil and sweet orange oil.

4. A method for preparing odorless DHA small drop pills, characterized in that: The following steps are involved: Pour the oil and N-acetylneuraminic acid into an emulsifying tank and stir to mix uniformly to obtain the contents, wherein the oil at least includes DHA algae oil; Pour water into a gelling tank and set a high temperature environment, add glycerin and gelatin into the gelling tank in sequence, and stir the gelling until the gelatin is completely dissolved to obtain a transparent colloidal solution, wherein the gelatin includes pig skin gelatin and fish skin gelatin; The gelatin solution and the contents are sucked into a coaxial double-nozzle dropping pill making device and extruded to obtain dropping pills, wherein the gelatin solution is ejected from an external nozzle of the coaxial double-nozzle dropping pill making device, and the contents are ejected from an internal nozzle of the coaxial double-nozzle dropping pill making device, and the temperature of the contents is lower than the temperature of the gelatin solution; After the pellets are shaped and dried, odorless DHA pellets with a frosted appearance are obtained; The mass ratio of fish skin gelatin and pig skin gelatin in the gelatin is set to 0.1:1~1:1, and the ratio of N-acetylneuraminic acid and gelatin is set to 1:20~1:

40.

5. The method for preparing an odorless DHA small dropping pill according to claim 4, characterized in that: The coaxial double-nozzle drop-pill making equipment includes a coaxially arranged internal nozzle and external nozzle, wherein the gelatin solution is ejected from the external nozzle of the coaxial double-nozzle drop-pill making equipment, and the contents are ejected from the internal nozzle of the coaxial double-nozzle drop-pill making equipment, and the contents and the gelatin solution are extruded simultaneously to form a double-layer structure drop-pill, and the temperature of the contents is set to 40°C, and the temperature of the gelatin solution is set to 85°C.

6. The method for preparing an odorless DHA small dropping pill according to claim 4, characterized in that: Pour the oil and N-acetylneuraminic acid into the emulsification tank, set the stirring speed to 30~40HZ, stir for 20min~30min, start vacuuming simultaneously, set the vacuum degree to -0.5~-0.1Mpa, and stir to mix evenly to obtain the contents.

7. The method for preparing an odorless DHA small dropping pill according to claim 4, characterized in that: Pour water into the gelatinization tank and set the high temperature to 80℃~85℃. Add glycerin and gelatin to the gelatinization tank in sequence and stir. Set the stirring speed to 40~50HZ. Stir the gelatinization tank until the gelatin is completely dissolved to obtain a transparent colloidal solution. After vacuum degassing, place it at 80℃~85℃ and keep it warm for later use.

Images