Preparation method of composition and decoction for treating hyperlipemia

Abstract

The invention discloses a composition for treating hyperlipidemia and a preparation method thereof. The composition comprises striga asiatica extract; the extract is any one or more of rhizoma pinellinae praeparata, radix pseudostellariae, anoectochilus formosanus and mangnolia officinalis. The hyperlipemia is spleen deficiency and phlegm dampness type hyperlipemia, and the extract is decocted with water and extracted. The medicine comprises the following components in parts by mass: 10 parts of striga asiatica, 10 parts of rhizoma pinellinae praeparata and 5 parts of anoectochilus formosanus. 15 parts of radix pseudostellariae, 10 parts of rhizoma atractylodis and 10 parts of cortex magnoliae officinalis; , 10 parts of fried hawthorn, 15 parts of Poria cocos and 10 parts of Gorgon fruit. Mixing and crushing the composition, and putting the crushed composition into a decoction bag; soaking the decoction bag in 10 times of cold boiled water for set time TA; preparing liquid A is formed; heating the prepared liquid A and the decoction bag with strong fire until boiling; preparing liquid B is formed; decocting with slow fire to prepare liquid B and a medicine decocting bag, and setting time TB; preparing liquid C; and filtering to prepare liquid C to obtain filtrate A and decoction dregs A. The filtrate A is the decoction for treating hyperlipemia.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions and preparation methods thereof, and in particular to Chinese medicine compositions for treating hyperlipidemia and preparation methods thereof. Background Art

[0002] Hyperlipidemia refers to a condition in which the fasting triglyceride and / or total cholesterol levels in the blood are abnormally elevated. Its types include hypertriglyceridemia, hypercholesterolemia, combined hyperlipidemia, and elevated low-density lipoprotein levels. In terms of etiology, hyperlipidemia can be divided into genetic factors and non-genetic factors.

[0003] As a common metabolic disorder, hyperlipidemia is closely related to lipid metabolism imbalance and has been shown to significantly increase the risk of cardiovascular disease. Previous studies have shown that ischemic cardiomyopathy, hypertensive cardiomyopathy, and diabetic cardiomyopathy are common causes of myocardial damage and necrosis. Myocardial cell damage can also occur in conditions such as hyperthyroidism, renal failure, and viral myocarditis. The emergence and development of these diseases are usually related to abnormal lipid metabolism. For example, patients with coronary heart disease and diabetes are often accompanied by dyslipidemia.

[0004] Histopathological studies further revealed that hyperlipidemia may lead to myocardial structural disorder, myocardial cell fibrosis and even interstitial hemorrhage.

[0005] A high-fat diet can induce apoptosis, ferroptosis, and autophagy, thereby participating in a variety of disease processes. From a biochemical point of view, a high-fat diet can stimulate inflammatory responses in the body, promote the generation of reactive oxygen species, inhibit the expression of nuclear factor E2-related factor 2 (Nrf2) in the antioxidant system, and affect the structure and function of mitochondria, ultimately causing damage to cardiomyocytes.

[0006] According to statistics, about one-third of heart disease cases worldwide can be attributed to hyperlipidemia, highlighting its severity as an important public health issue.

[0007] Hyperlipidemia not only has a high prevalence, but the age of diagnosis also tends to be younger.

[0008] Statins are the first choice for lowering serum total cholesterol. They effectively regulate blood lipid levels in plasma by inhibiting methylhydroxyglutaryl coenzyme A (HM-CoA) reductase, a key enzyme in the synthesis of cholesterol in the body. However, it is worth noting that lipid-lowering drugs usually require patients to take them for a long time or even for life, which may be accompanied by adverse reactions such as loss of appetite, indigestion, headache, dizziness, joint pain and abnormal liver function, all of which may affect the patient's quality of life and treatment compliance.

[0009] Therefore, developing new drugs with independent intellectual property rights to meet the treatment needs of hyperlipidemia not only has important clinical and economic value, but also has far-reaching significance for scientific research practice. Summary of the invention

[0010] In order to provide a Chinese medicine composition for treating hyperlipidemia and a preparation method thereof, a convenient form of medication can be provided, while the effectiveness of the active ingredients of the medicine can be guaranteed, and the user experience can be improved and the drug effect can be guaranteed.

[0011] The technical solution of the present application to solve the above technical problem is a composition for treating hyperlipidemia, including: a Striga Root extract.

[0012] The above-mentioned composition for treating hyperlipidemia also includes any one or more extracts of Pinellia ternata, Anoectochilus roxburghii, Pseudostellaria pubescens, Magnolia officinalis, Atractylodes lancea, Poria cocos, Euryale ferox, and stir-fried Crataegus pinnatifida.

[0013] The above-mentioned composition for treating hyperlipidemia also includes any one of the following technical features: TH1: the above-mentioned hyperlipidemia is hyperlipidemia of spleen deficiency and phlegm-dampness type; TH2: the above-mentioned extract is extracted by boiling with water; TH3: the above-mentioned extract includes any one or more of the following components: apigenin-7-galacturonide, apigenin-7-O-β-D-pyranoglucopyranoside, quercetin, acaciatin-7-O-β-D-glucuronide, apigenin, and euphorbia solani.

[0014] The technical solution of the present application for solving the above technical problem can also be a composition for treating hyperlipidemia, wherein the components of the above medicine and their mass ratios are: 10 parts of Strigosa Root, 10 parts of Pinellia Terrestris, and 5 parts of Anoectochilus Roxb.

[0015] The above-mentioned composition for treating hyperlipidemia also includes: any one or more of the following components: 15 parts of Pseudostellariae Radix, 10 parts of Atractylodes lancea, 10 parts of Magnolia officinalis, 10 parts of stir-fried Crataegus pinnatifida, 15 parts of Poria cocos, and 10 parts of Euryale ferox.

[0016] The above-mentioned composition for treating hyperlipidemia can be 10 parts of Striga, 10 parts of Pinellia, 5 parts of Anoectochilus, 15 parts of Pseudostellariae Radix, 10 parts of Atractylodes, and 10 parts of Magnolia officinalis. The above-mentioned composition for treating hyperlipidemia can be 10 parts of Striga, 10 parts of Pinellia, 5 parts of Anoectochilus, 10 parts of Stir-fried Crataegus, 15 parts of Poria, and 10 parts of Euryale. In this application, 1 part can be 1g, that is, 1 gram, and the specific weight can be adjusted according to the patient's weight and condition.

[0017] The technical solution of the present application to solve the above-mentioned technical problem can also be a composition for treating hyperlipidemia, including 10 parts of Herba Striatum, and any one or more of the following components: 15 parts of Pseudostellariae Radix, 10 parts of Magnolia officinalis, 10 parts of Atractylodes macrocephala, 10 parts of Pinellia ternata, 5 parts of Anoectochilus roxburghii, 10 parts of stir-fried Hawthorn, 15 parts of Poria cocos, and 10 parts of Euryale ferox.

[0018] The components of the composition for treating hyperlipidemia and their weight ratios can be: 10 parts of Strigosa Striga, 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes, and 10 parts of Magnolia officinalis.

[0019] The components of the composition for treating hyperlipidemia and their weight ratios can be: 10 parts of Strigosa Striga, 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes, 10 parts of Magnolia officinalis, and 10 parts of Pinellia ternata.

[0020] The components of the composition for treating hyperlipidemia and their weight ratios can be: 10 parts of Strigosa Root, 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes Macrocephalae, 10 parts of Magnolia Officinalis, and 5 parts of Anoectochilus Roxb.

[0021] The components of the composition for treating hyperlipidemia and their weight ratios can be: 10 parts of Strigosa Root, 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes Macrocephalae, 10 parts of Magnolia Officinalis, 10 parts of Pinellia Ternate, and 5 parts of Anoectochilus Roxb.

[0022] The components of the composition for treating hyperlipidemia and their weight ratios can be 10 parts of Strigosa Striga, 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes, 10 parts of Magnolia officinalis, and 10 parts of stir-fried Crataegus pinnatifida.

[0023] The components of the composition for treating hyperlipidemia and their weight ratios can be: 10 parts of Strigosa Striga, 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes macrocephala, 10 parts of Magnolia officinalis, and 15 parts of Poria.

[0024] The components of the composition for treating hyperlipidemia and their weight ratios can be 10 parts of Strigosa Striga, 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes macrocephala, 10 parts of Magnolia officinalis, and 10 parts of Euryale ferox.

[0025] The components of the composition for treating hyperlipidemia and their weight ratios can be 10 parts of Strigosa Root, 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes, 10 parts of Magnolia Officinalis, 10 parts of stir-fried Crataegus, 15 parts of Poria, and 10 parts of Euryale.

[0026] The technical solution of the present application to solve the above technical problems can also be a method for preparing a decoction for treating hyperlipidemia, comprising: step S1: mixing and crushing the above composition and putting it into a decoction bag; step S2: soaking the above decoction bag with 10 times the amount of cold boiled water for a set time TA to form a prepared liquid A; step S3: heating the above prepared liquid A and the decoction bag with high heat until boiling to form a prepared liquid B; step S4: decocting the prepared liquid B and the decoction bag with low heat for a set time TB to obtain a prepared liquid C; step S5: filtering the prepared liquid C to obtain a filtrate A and a dregs A, wherein the above filtrate A is a decoction for treating hyperlipidemia.

[0027] The preparation method of the above-mentioned decoction for treating hyperlipidemia comprises: step S6: boiling the medicinal residue A with 8 times the amount of cold boiled water for a second time; step S7: the second decoction comprises heating to boiling over high heat, then boiling over low heat for a set time TC to obtain a prepared liquid D; step S8: filtering the prepared liquid D to obtain a filtrate B and the medicinal residue B; step S9: combining the above-mentioned filtrate A and filtrate B to obtain a filtrate C; the above-mentioned filtrate C is a decoction for treating hyperlipidemia.

[0028] The preparation method of the decoction for treating hyperlipidemia comprises: step S10: filtering and concentrating the filtrate to obtain a concentrated solution D, wherein the concentrated solution D is the decoction for treating hyperlipidemia.

[0029] The above-mentioned set soaking time TA ranges from 10 minutes to 20 minutes, and can also be 11, 12, 13, 14, 15, 16, 17, 18, 19 minutes; the above-mentioned set time TB ranges from 15 minutes to 25 minutes, and can also be 16, 17, 18, 19, 20, 21, 22, 23, 24, 25 minutes; the above-mentioned set time TC ranges from 10 minutes to 20 minutes, and can also be 11, 12, 13, 14, 15, 16, 17, 18, 19 minutes.

[0030] One of the technical effects of the above technical solution: Striga: Rich in quercetin and apigenin, Striga exhibits significant antioxidant and anti-inflammatory activity. Studies have shown that it can reduce lipid peroxidation and protect vascular endothelial cells by reducing the level of reactive oxygen species (ROS).

[0031] According to records, Herba Monogatii has the effect of strengthening the spleen, but there is no clear prescription and extract for the treatment of hyperlipidemia. The creative use of Herba Monogatii in the treatment of hyperlipidemia in this application is a powerful exploration of the potential of traditional Chinese medicine.

[0032] One of the technical effects of the above technical solution: Herba Polygoni Multiflori is sweet and light in taste, cool in nature, and has the effects of clearing away heat and eliminating accumulation, clearing the liver and strengthening the spleen. It is a treasure among traditional medicinal plants in Guangdong and Guangxi. It has rich chemical components, including apigenin-7-galacturonide, apigenin-7-O-β-D-pyranoglucopyranoside, quercetin, acacia-7-O-β-D-glucuronide, apigenin and scutellariae, etc. Quercetin, as a plant flavonoid compound, has very strong antioxidant properties.

[0033] Quercetin can prevent cell apoptosis caused by cytokines, promote glucose-stimulated secretion of insulin (GSIS), and inhibit the accumulation of reactive oxygen species (ROS) and nitric oxide (NO). Its mechanism of action is closely related to the reduction of inducible nitric oxide synthase (iNOS) expression and the inhibition of nuclear translocation of nuclear factor-κB (NF-κB). Apigenin has multiple biological activities such as anti-inflammatory, cytotoxicity reduction and antioxidant. The presence of these components is closely related to the good antioxidant pharmacological activity of Striga.

[0034] The polysaccharide of Radix Aconitifolii has the ability to scavenge free radicals and shows significant antioxidant activity in vitro.

[0035] One of the technical effects of the above technical solution is that the combination of Herba Monogatii with other drugs further enhances the therapeutic effect on hyperlipidemia of spleen deficiency and phlegm-dampness type.

[0036] One of the technical effects of the above technical solution is that the combination of Pinellia ternata and Herba Glehniae, the main ingredient of Pinellia ternata, zingiberenic acid, has significant expectorant, anti-tumor and antioxidant effects, and helps to lower blood lipid levels.

[0037] One of the technical effects of the above technical solution: the combination of Anoectochilus roxburghii and Adenophora tatarinowii. Anoectochilus roxburghii: contains rich polyphenols and flavonoids. Anoectochilus roxburghii has a significant free radical scavenging effect, can regulate the antioxidant defense mechanism, and reduce the inflammatory response caused by a high-fat diet.

[0038] One of the technical effects of the above technical solution: Pseudostellaria baicalensis is combined with Radix Aconiti Lateralis: Pseudostellaria baicalensis is rich in saponins and polysaccharides. Modern research reveals that it has antioxidant and immune-enhancing effects, which helps to alleviate the adverse effects of oxidative stress on lipid metabolism.

[0039] One of the technical effects of the above technical scheme is that Atractylodes lancea and Strigosa Root are combined, containing ingredients such as atractylodes ketone and ligustilide. Atractylodes lancea can significantly inhibit lipid peroxidation, enhance the detoxification function of the liver, and regulate intestinal flora to improve lipid metabolism.

[0040] One of the technical effects of the above technical solution: Magnolia officinalis and Herba Stemonae are combined, and Magnolia officinalis: magnolia officinalis phenol and magnolol show significant anti-inflammatory and antioxidant properties, which can improve the intestinal flora environment, reduce the level of inflammatory factors in the body, and fight against lipid metabolism abnormalities caused by oxidative stress.

[0041] One of the technical effects of the above technical solution is that hawthorn and tricholoma are combined. Hawthorn contains flavonoids and triterpenes. Hawthorn has the effects of lowering blood lipids, promoting fat metabolism and resisting atherosclerosis.

[0042] One of the technical effects of the above technical solution is that Poria cocos is combined with Herba Stemonae Radix and Poria cocos contains rich Poria cocos polysaccharides, which has the effects of promoting diuresis and removing dampness and enhancing immune function. Modern pharmacological research has proved that it has significant effects in anti-inflammatory and regulating blood lipids.

[0043] One of the technical effects of the above technical solution is that the polysaccharide and saponin components in Gorgon fruit can promote fat metabolism, regulate water metabolism, and significantly improve abnormal liver lipid metabolism in patients with hyperlipidemia when Gorgon fruit is combined with Gorgon fruit.

[0044] In this application, the composition and compatibility of the Chinese medicine prescription are optimized, and a new Chinese medicine formula is developed to effectively treat spleen deficiency and phlegm dampness type hyperlipidemia. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] Figure 1 It is a schematic flow chart of a preparation method of a composite decoction for treating hyperlipidemia;

[0046] Figure 2 The present invention is a schematic flow chart of a method for preparing a composite decoction for treating hyperlipidemia. DETAILED DESCRIPTION

[0047] The content of this application is further described in detail below in conjunction with the accompanying drawings. It should be noted that the following is a description of the preferred embodiments of the present invention and does not constitute any limitation to the present invention. The description of the preferred embodiments of the present invention is only an illustration of the general principles of the present invention. The numbers such as "first", "second" and "A" and "B" involved in the present invention are only for the convenience of explanation and do not represent a temporal or spatial order relationship.

[0048] As the treasure of traditional Chinese medicine, Chinese medicine has undergone thousands of years of development and improvement, forming a unique theoretical system and practical methods. Chinese medicine treatment emphasizes "holistic thinking" and "differential diagnosis and treatment", preventing and treating diseases and regulating the body from the aspects of internal organs, qi and blood, yin and yang.

[0049] Therefore, based on the pathogenesis of the disease and the treatment needs of patients, developing and researching a Chinese medicine composition and preparation method for the treatment of hyperlipidemia has important and extensive clinical value, economic value and scientific research practice value. The prevention and treatment of the three highs, namely hyperlipidemia, by traditional Chinese medicine is also one of the hot spots and innovation points of future medical research.

[0050] The mechanism of action of hyperlipidemia in this application is mainly anti-oxidation. Oxidative stress plays a vital role in the formation and development of hyperlipidemia. In white adipose tissue, proinflammatory mediators, such as tumor necrosis factor-α (TNF-α) and endotoxin (LPS), can cause mitochondrial dysfunction, which is closely related to impaired lipolysis and reduced energy expenditure. The reduction in energy metabolism in adipose tissue may further lead to a reduced absorption of low-density lipoprotein (LDL) particles in the blood, thereby affecting the absorption and utilization of low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and total cholesterol (TC) in adipose tissue. Studies have shown that in a mouse model lacking sphingomyelin synthase 1, increased oxidative stress impairs lipid storage function and leads to increased triglyceride levels. Therefore, reducing oxidative stress levels can reduce the risk of hyperlipidemia.

[0051] TCM interpretation of hyperlipidemia: Although there is no name of "hyperlipidemia" in ancient Chinese medical books, it is often classified as "fat turbidity" for discussion. As early as the period of "Inner Canon of Medicine", the ancients had a rudimentary understanding of blood lipids, and often used words such as "fat", "cream" and "fat" to describe blood lipids. "Suwen·Tongping Xushilun" mentioned: "Fullness of qi and greasy, sweet and fat nobles, then the rich and fat people are the rich and fat people." "Suwen·Yifa Fangyi Lun" also said: "The Chinese people eat fat and fat, so evil cannot hurt their bodies."

[0052] In the Lingshu·Five Grains and Fluids, the ancients described in detail the process of the fluids of the five grains converging into paste: "The fluids of the five grains combined into paste, seep into the bone voids, nourish the brain and marrow, and flow down to the genitals and thighs." Zhang Jiebin further commented in the Leijing: "The semen is combined into paste to fill the bone voids, which is the brain and marrow, the essence and blood." In addition, doctors of all dynasties have made detailed identifications of pastes and fats. For example, it is stated in the Liyi Tongze: "The condensed one is fat, and the released one is paste", which distinguishes the difference between fat and paste from the morphology. The Lingshu·Wei Qi Disorder further elaborates on the physiological characteristics of paste and its relationship with constitution: "The paste has more qi, the one with more qi is hot, and the one with heat is cold-resistant", "The flesh of the paste falls off", "The fat people have a long belly and fat", all of which are consistent with the concept of "fat" in modern medicine.

[0053] Li Dongyuan proposed in "On the Spleen and Stomach": "All diseases are caused by the weakness of the spleen and stomach." Zhang Zhicong's "Collected Annotations to the Lingshu" records: "The qi in the middle burner steams and turns into fluid. If its essence overflows to the outside, the skin and flesh will be fat and fat, and if it remains inside, the skin and flesh will be fat and fat." "Must-Reads in the Medical Ancestral" also states: "When the spleen and earth are weak, the clear is difficult to rise and the turbid is difficult to descend. It stays in the middle and stagnates, and becomes phlegm due to blood stasis." These all clearly point out that the generation and transformation of "fat" and "phlegm and turbidity" are closely related to the spleen's transportation and transformation function. The spleen's function of raising the clear and lowering the turbid plays a key role in the process of lipid metabolism. The so-called "all swellings and fullness belong to the spleen."

[0054] The basic pathogenesis is that the spleen fails to function properly, phlegm and turbidity are generated internally, and fat and fat are transported obstructed, while improper diet is an external factor. "Medical Essentials" also says: "The spleen is the source of phlegm. Treating phlegm without taking care of the spleen and stomach is not the right treatment." "The spleen is the source of phlegm." If the spleen is weak and the transportation and transformation are abnormal, the spleen cannot disperse essence, resulting in water retention and gradually generating phlegm, dampness, and water. Phlegm, dampness, and water condense and gather into phlegm and turbidity over time, and the drainage is blocked, and turbid fat accumulates in the body, causing abnormal blood lipids.

[0055] The etiology and pathogenesis of spleen deficiency and phlegm dampness type hyperlipidemia is that people are fond of rich and greasy food. Rich and sweet food can easily damage the middle qi, so that the clear qi does not rise, and the turbid yin remains alone. The spleen and stomach cannot transport and transform the essence of qi, which turns water into dampness and grain into stagnation. When the body is weak and stagnant, water will stagnate in the middle and become drink, and dampness will condense into phlegm; phlegm and dampness can also block the spleen yang, causing the qi to fail to be regulated, and the clear qi will not rise but accumulate fat and phlegm turbidity inside, resulting in the appearance of fat turbidity. Therefore, the treatment of spleen deficiency and phlegm dampness type hyperlipidemia with traditional Chinese medicine should focus on the treatment methods of strengthening the spleen and removing dampness, resolving phlegm and purging turbidity, so as to restore the spleen's transportation and transformation function, remove phlegm and dampness in the body, and thus achieve the purpose of treating hyperlipidemia.

[0056] Striga is a semi-parasitic herbaceous plant of the Orobanchaceae family. It can grow up to 30 cm tall, erect, with solitary stems. The leaves are narrow, only the base is narrowly lanceolate, and the rest are linear, sometimes scaly. The flowers are solitary in the axillary or form spikes at the top of the stem; the calyx is ribbed, with awl-shaped lobes; the corolla is usually yellow, red or white, and the capsule is ovate, enclosed in a persistent calyx. It blooms in autumn.

[0057] Striga is distributed in Yunnan, Guizhou, Guangxi, Guangdong, Hunan, Jiangxi, Fujian, and Taiwan in China; it is widely distributed in tropical Asia and tropical Africa. It grows in low-altitude farmland, grasslands on barren hills, edges of fields, valleys, and cultivated land. It parasitizes on the roots of its host.

[0058] The whole herb of unilateral gold is used for medicine, and the main application scenario in traditional Chinese medicine is to treat malnutrition in children. Other names: unilateral gold (malnutrition), ground Ding grass, malnutrition grass, and thin unilateral gold. In the countryside, unilateral gold is occasionally called "scrophularia", but it is not the scrophularia in traditional Chinese medicine.

[0059] The taste of Radix Trichosanthis is sweet and light, and it is cool in nature. It has the effect of clearing away heat and promoting digestion. 1. It can be used to treat diarrhea in children, icteric hepatitis, and children's summer fever. 2. It can also be used to prevent children's summer fever, simple indigestion and other symptoms. If there are symptoms such as hepatitis, low fever, rib pain, etc., it can also be used to regulate the body.

[0060] As a traditional pediatric drug, Herba Stramonium is rarely used to treat adult diseases, and there is no precedent for its use in hyperlipidemia. The potential of this drug has not been further explored.

[0061] In the present application, an embodiment of a composition for treating hyperlipidemia includes: a Striga tataricus extract.

[0062] The above-mentioned composition for treating hyperlipidemia also includes: any one or more extracts of Pinellia ternata, Radix Pseudostellariae, Rhizoma Anoectochilae, and Magnolia officinalis.

[0063] The above-mentioned hyperlipidemia is hyperlipidemia of spleen deficiency and phlegm-dampness type, and the above-mentioned extract is extracted by boiling with water.

[0064] In the present application, in an embodiment of a composition for treating hyperlipidemia, the components of the above-mentioned drug and their weight ratios are: 10 parts of Strigosa Striga, 10 parts of Pinellia ternata, and 5 parts of Anoectochilus roxburghii.

[0065] In the present application, an embodiment of a composition for treating hyperlipidemia includes: 10 parts of Strigosa Striga, 10 parts of Pinellia ternata, 5 parts of Anoectochilus roxburghii, 15 parts of Pseudostellaria heterophylla, 10 parts of Atractylodes lancea, and 10 parts of Magnolia officinalis.

[0066] In the present application, an embodiment of a composition for treating hyperlipidemia includes: 10 parts of Herba Strigosae Radix, 10 parts of Herba Pinelliae Rhizoma, 5 parts of Herba Anoectochilae, 10 parts of Fried Crataegus Pinelliae, 15 parts of Poria cocos, and 10 parts of Euryale ferox.

[0067] In the present application, an embodiment of a composition for treating hyperlipidemia includes: 10 parts of Strigosa Striga, 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes macrocephala, and 10 parts of Magnolia officinalis.

[0068] In the present application, an embodiment of a composition for treating hyperlipidemia includes: 10 parts of Strigosa Striga, 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes macrocephala, 10 parts of Magnolia officinalis, and 10 parts of Pinellia ternata.

[0069] In the present application, an embodiment of a composition for treating hyperlipidemia includes: 10 parts of Strigosa Striga, 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes macrocephala, 10 parts of Magnolia officinalis, and 5 parts of Anoectochilus roxburghii.

[0070] In the present application, an embodiment of a composition for treating hyperlipidemia includes: 10 parts of Herba Strigosae Radix, 15 parts of Radix Pseudostellariae Radix, 10 parts of Atractylodes macrocephalae, 10 parts of Magnolia officinalis, 10 parts of Pinellia ternatae, and 5 parts of Anoectochilus roxburghii;

[0071] In the present application, an embodiment of a composition for treating hyperlipidemia includes: 10 parts of Strigosa Striga, 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes, 10 parts of Magnolia officinalis, and 10 parts of stir-fried Hawthorn;

[0072] In the present application, an embodiment of a composition for treating hyperlipidemia includes: 10 parts of Strigosa Striga, 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes macrocephala, 10 parts of Magnolia officinalis, and 15 parts of Poria cocos;

[0073] In the present application, an embodiment of a composition for treating hyperlipidemia includes: 10 parts of Herba Strigosae Radix, 15 parts of Radix Pseudostellariae Radix, 10 parts of Atractylodes macrocephalae, 10 parts of Magnolia officinalis, and 10 parts of Euryale ferox;

[0074] In the present application, an embodiment of a composition for treating hyperlipidemia includes: 10 parts of Herba Strigosae Radix, 15 parts of Radix Pseudostellariae Radix, 10 parts of Atractylodes macrocephala, 10 parts of Magnolia officinalis, 10 parts of stir-fried Hawthorn, 15 parts of Poria cocos, and 10 parts of Euryale ferox.

[0075] like Figure 1 In an embodiment of a method for preparing a decoction for treating hyperlipidemia, the method comprises the following steps: step S1: mixing and crushing the composition and putting it into a decoction bag; step S2: soaking the decoction bag with 10 times the amount of cold boiled water for a set time TA; forming a prepared liquid A; the soaking set time TA includes 15 minutes; step S3: heating the prepared liquid A and the decoction bag with high heat until boiling; forming a prepared liquid B; step S4: decocting the prepared liquid B and the decoction bag with low heat for a set time TB; obtaining a prepared liquid C; step S5: filtering the prepared liquid C to obtain a filtrate A and a dregs A, wherein the filtrate A is a decoction for treating hyperlipidemia.

[0076] like Figure 2 In an embodiment of a method for preparing a decoction for treating hyperlipidemia, the method further includes: step S6: boiling the residue A with 8 times the amount of cold boiled water for a second time; step S7: the second decoction includes heating to boiling over high heat, then boiling over low heat for a set time TC to obtain a prepared liquid D; step S8: filtering the prepared liquid D to obtain a filtrate B and the residue B; step S9: combining the filtrate A and the filtrate B to obtain a filtrate C; the filtrate C is a decoction for treating hyperlipidemia.

[0077] In the present application, an embodiment of a method for preparing a decoction for treating hyperlipidemia further includes step S10: filtering and concentrating the filtrate to obtain a concentrated solution D, wherein the concentrated solution D is a decoction for treating hyperlipidemia.

[0078] In the present application, in an embodiment of a method for preparing a decoction for treating hyperlipidemia, the above-mentioned set soaking time TA ranges from 10 minutes to 20 minutes, and can also be 11, 12, 13, 14, 15, 16, 17, 18, and 19 minutes; the above-mentioned set time TB ranges from 15 minutes to 25 minutes, and can also be 16, 17, 18, 19, 20, 21, 22, 23, 24, and 25 minutes; the above-mentioned set time TC ranges from 10 minutes to 20 minutes, and can also be 11, 12, 13, 14, 15, 16, 17, 18, and 19 minutes.

[0079] The composition for treating hyperlipidemia in the present application is for treating hyperlipidemia of spleen deficiency and phlegm-dampness type.

[0080] The extract of Herba Stramonium is creatively used to treat hyperlipidemia. It is combined with any one or more extracts of Herba Pinelliae, Radix Pseudostellariae, Herba Anoectochilae, and Herba Magnoliae to have a unique therapeutic effect on hyperlipidemia of spleen deficiency and phlegm dampness type.

[0081] Herba Monogatii: sweet, neutral. Enters the liver, spleen, and kidney meridians. [Functions and indications] Strengthens the spleen, soothes the liver and eliminates stagnation, clears away heat and promotes urination. Used for children with indigestion, malnutrition, and urinary problems. Although Herba Monogatii has been documented to strengthen the spleen, no clear prescription or extract has been found for the treatment of hyperlipidemia.

[0082] In the present application, Herba Monogatii is combined with other drug combinations to further enhance the therapeutic effect on hyperlipidemia of spleen deficiency and phlegm-dampness type.

[0083] Banxia: pungent, warm. Enters the spleen, stomach, and lung meridians. [Functions and indications] Drys dampness and resolves phlegm. Used for cough and asthma due to excessive phlegm, dizziness and palpitations caused by phlegm and fluid, dizziness caused by wind and phlegm, and headache caused by phlegm.

[0084] Anoectochilus roxburghii: sweet, cool in nature. Enters the lung, liver, kidney, and bladder meridians. [Functions and indications] Clears heat and cools blood, removes dampness and detoxifies. Used for lung heat cough, hemoptysis, hematuria, infantile convulsions, tetanus, edema, rheumatic pain, and traumatic injuries. Anoectochilus roxburghii is sweet in taste, cool in nature, and is good at removing dampness and detoxification, and is used as an adjuvant. The whole formula can be used together to strengthen the spleen and eliminate turbidity, remove turbidity and reduce fat, and can treat both spleen deficiency and phlegm turbidity.

[0085] Pseudostellariae Radix is ​​sweet, slightly bitter, neutral in nature, and enters the spleen and lung meridians, replenishing qi and tonifying the spleen. Enters the spleen and lung meridians. [Functions and Indications] Replenishing qi and strengthening the spleen, promoting fluid production and moistening the lungs. Used for spleen deficiency, fatigue, loss of appetite, weakness after illness, insufficient qi and yin, spontaneous sweating and thirst, and dry cough due to lung dryness.

[0086] Atractylodes is bitter and warm, mainly for drying dampness and strengthening the spleen. "Ming Yi Bie Lu" says that it "warms the stomach, digests food and makes people eat more." Atractylodes: pungent, bitter, warm in nature. It enters the spleen, stomach, and liver meridians. [Functions and indications] Strengthen the spleen, dry dampness, relieve depression, and eliminate filth. It treats dampness that blocks the spleen, fatigue and sleepiness, abdominal distension, loss of appetite, vomiting, diarrhea, dysentery, malaria, phlegm and fluid, edema, seasonal colds, wind-cold dampness, foot paralysis, and night blindness.

[0087] Magnolia officinalis: bitter, pungent, warm in nature. Enters the large intestine meridian. [Functions and indications] Promotes qi and eliminates stagnation, dries dampness and eliminates fullness, and relieves asthma. Indications: food stagnation and qi stagnation, abdominal distension and constipation, dampness blocking the middle jiao, abdominal distension and vomiting and diarrhea, phlegm obstruction and qi reversal, chest fullness and cough. Magnolia officinalis focuses on drying dampness and eliminating phlegm, descending qi and eliminating fullness, dredging qi and removing phlegm and dampness. The three are one strengthening and one moving, promoting qi and invigorating the spleen and removing dampness, so that qi moves and dampness is transformed, dampness is eliminated, spleen function is strengthened, phlegm turbidity is eliminated, and qi and blood are smooth.

[0088] Hawthorn: sour, sweet, slightly warm. Enters the spleen, stomach, and liver meridians. [Functions and indications] Digest food and eliminate stagnation, promote qi and disperse blood stasis. Indications: food stagnation, diarrhea and abdominal pain, hernia pain, chest and abdominal pain due to blood stasis, and dysmenorrhea. Hawthorn is warm in nature, sour and sweet in taste, helps digestion and strengthens the stomach, eliminates turbidity and reduces fat. "Pharmaceutical Chemistry" says: "Taking its sour taste, it belongs to Jia, and its sweet taste belongs to Ji. The combination of sour and sweet, Jia and Ji transforms into earth, and enters the spleen to help it transport and transform. It mainly eliminates livestock meat, food stagnation, greasy and fishy, ​​fruits, phlegm and fluid, fullness and swelling, fullness and acid regurgitation, and milk stagnation in children." Herba Polygoni Multiflori is sweet in taste, strengthens the spleen and eliminates stagnation, and complements hawthorn to strengthen the function of strengthening the spleen and eliminating stagnation.

[0089] Poria: sweet, light, neutral in nature. Enters the heart, lung, spleen, and kidney meridians. [Functions and indications] Infiltrates dampness and promotes diuresis, strengthens the spleen, and calms the mind. Used for edema, oliguria, phlegm and fluid, palpitations, spleen deficiency, poor appetite, loose stools, restlessness, palpitations, and insomnia. Poria is intended to infiltrate dampness and promote diuresis; Pinellia is intended to invigorate the spleen and dry dampness. One infiltrates and the other invigorates. The two drugs work together to remove phlegm turbidity and phlegm dampness, that is, "eliminating the phlegm that has already been generated and stopping the source of the phlegm."

[0090] Gorgon fruit: sweet, astringent, neutral in nature. Enters the spleen and kidney meridians. [Functions and indications] Strengthens the kidney and consolidates the essence, tonifies the spleen and stops diarrhea, removes dampness and stops leukorrhea. Used for spermatorrhea, nocturnal emission, frequent urination, spleen deficiency and chronic diarrhea, leukorrhea, and leukorrhea. Gorgon fruit strengthens the spleen and removes dampness. "Compendium of Materia Medica 100 Records" says: "Gorgon fruit is sweet and light, with the true taste of earth, and is a medicine for the spleen and kidney. The spleen hates dampness and the kidney hates dryness. Gorgon fruit is light, sweet and fragrant, so it will not be harmed by dampness. It is sticky and astringent, but also smooth and moist, so it will not be harmed by dryness. All medicines for the spleen and kidney are often opposite, but this one complements each other, so it is particularly valuable."

[0091] Clinical application examples:

[0092] Case 1: Mr. Tan, male, 30 years old, came to our outpatient clinic on October 19, 2024 due to "snoring for 1 year." Previous physical examination revealed hyperlipidemia, and the total cholesterol was 5.6mmol / L.

[0093] TCM diagnosis: 1. Snoring due to spleen deficiency and phlegm-dampness 2. Fat turbidity due to spleen deficiency and phlegm-dampness.

[0094] Western medicine diagnosis: 1. Snoring 2. Hyperlipidemia. Symptoms: obesity, dislike of meat, poor appetite, obvious snoring at night, fatigue during the day, normal sleep, normal urination, loose stools, pale red tongue, teeth marks on the edges, thin white fur, and floating and slippery pulse. After 7 doses of the present invention, the appetite improved, the body weight decreased by 5K, the stools were soft and formed, and the total cholesterol was checked: 4.53mmol / L.

[0095] Case 2: Ms. Gao, female, 64 years old, was hospitalized in our hospital on October 15, 2024 due to "recurrent low back pain for more than 20 years, accompanied by pain in both lower limbs for 8 years." Physical examination: height: 163cm, weight: 92.9kg, BMI: 35; total cholesterol: 5.16mmol / L, low-density lipoprotein: 4.15mmol / L.

[0096] TCM diagnosis: 1. Fatty turbidity, spleen deficiency, phlegm and dampness.

[0097] Western medicine diagnosis: hyperlipidemia.

[0098] Symptoms: obesity, abdominal distension, poor appetite, diarrhea after eating cold food. Sleeping normally, normal urination, pale tongue, white and greasy fur, and deep and slippery pulse. After 7 doses of the present invention, abdominal distension and appetite were improved, and body weight decreased by 3kg. Total cholesterol: 4.36mmol / L, low-density lipoprotein: 3.06mmol / L.

[0099] Example 3: Mr. Liang, male, 31 years old, came to our outpatient clinic for treatment on October 19, 2024 because of "physical examination found hyperlipidemia for 1 month." Physical examination in other hospitals: total cholesterol: 5.36mmol / L, low-density lipoprotein: 4.53mmol / L.

[0100] TCM diagnosis: 1. Fatty turbidity, spleen deficiency, phlegm and dampness.

[0101] Western medicine diagnosis: hyperlipidemia.

[0102] Symptoms: epigastric distension and discomfort, aggravated after eating, occasional belching. Normal appetite and sleep, normal urination, loose stools, pale tongue, teeth marks on the edges, white fur, and deep and slippery pulse. After 7 doses of the present invention, the epigastric distension and discomfort were improved compared with the previous ones. Total cholesterol: 5.19mmol / L, low-density lipoprotein: 4.12mmol / L.

[0103] In the present application, the composition and preparation method for treating hyperlipidemia include: extract of Herba Stramonii; extract of any one or more of Herba Pinelliae, Radix Pseudostellariae, Herba Anoectochilae, and Herba Magnoliae. Hyperlipidemia is hyperlipidemia of spleen deficiency and phlegm-dampness type, and the extract is extracted by boiling with water. The components of the medicine and their mass ratios are: 10 parts of Herba Stramonii, 10 parts of Herba Pinelliae, 5 parts of Herba Anoectochilae; 15 parts of Radix Pseudostellariae, 10 parts of Herba Anoectochilae, 10 parts of Herba Magnoliae; 10 parts of Stir-fried Crataegus, 15 parts of Poria, and 10 parts of Euryale. The composition is mixed and crushed, and put into a decoction bag; the decoction bag is soaked with 10 times the amount of cold boiled water for a set time TA; a prepared liquid A is formed; the prepared liquid A and the decoction bag are heated to boiling with high heat; a prepared liquid B is formed; the prepared liquid B and the decoction bag are decocted with a slow fire for a set time TB; a prepared liquid C is obtained; the prepared liquid C is filtered to obtain a filtrate A and a dregs A, and the filtrate A is a decoction for treating hyperlipidemia.

[0104] Although the present invention is illustrated and described according to the preferred embodiment and several alternatives, the invention is not limited by the specific description in this specification. Other additional replacement or equivalent components can also be used to practice the present invention.

Claims

1. A composition for treating hyperlipidemia, characterized in that: include: Striga extract.

2. The composition for treating hyperlipidemia according to claim 1, characterized in that: Also includes: Extracts of any one or more of Pinellia ternata, Anoectochilus roxburghii, Pseudostellaria pseudoginseng, Magnolia officinalis, Atractylodes lancea, Poria cocos, Euryale ferox, and stir-fried hawthorn.

3. The composition for treating hyperlipidemia according to claim 1, characterized in that: Also includes any of the following technical features: TH1: The hyperlipidemia is of spleen deficiency and phlegm-dampness type; TH2: the extract is extracted by boiling with water; TH3: The extract includes any one or more of the following components: apigenin-7-galacturonide, apigenin-7-O-β-D-pyranoglucopyranoside, quercetin, acaciatin-7-O-β-D-glucuronide, apigenin, and euphorbia pulegone.

4. A composition for treating hyperlipidemia, characterized in that: The components and their mass ratios are: 10 parts of Strigosa Root, 10 parts of Pinellia Ternate, and 5 parts of Anoectochilus Roxb.

5. The composition for treating hyperlipidemia according to claim 4, characterized in that: The invention also comprises any one or more of the following components: 15 parts of Pseudostellariae Radix, 10 parts of Atractylodes lancea, 10 parts of Magnolia officinalis, 10 parts of stir-fried Crataegus pinnatifida, 15 parts of Poria cocos, and 10 parts of Euryale ferox.

6. A composition for treating hyperlipidemia, characterized in that: The invention comprises 10 parts of Radix Atractylodes Macrocephalae and any one or more of the following components: 15 parts of Radix Pseudostellariae, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Rhizoma Pinelliae, 5 parts of Radix Anoectochilus, 10 parts of Rhizoma Crataegus, 15 parts of Rhizoma Poriae, and 10 parts of Fructus Euryale.

7. A method for preparing a decoction for treating hyperlipidemia, characterized in that: include: Step S1: Mix and grind the composition according to any one of claims 1 to 6, and put it into a decoction bag; Step S2: soaking the decoction bag in 10 times the amount of cold boiled water for a set time TA to form a prepared liquid A; Step S3: heating the prepared liquid A and the decoction bag with high heat until boiling to form prepared liquid B; Step S4: decocting the prepared liquid B with a slow fire and setting the decoction bag for time TB to obtain the prepared liquid C; Step S5: filtering to prepare liquid C, obtaining filtrate A and medicinal residue A, wherein the filtrate A is a decoction for treating hyperlipidemia.

8. The method for preparing the decoction for treating hyperlipidemia according to claim 7, characterized in that: include: Step S6: mixing the medicinal residue A with 8 times the amount of cold boiled water for secondary decoction; Step S7: Secondary decoction includes heating to boiling over high heat, then decocting over low heat for a set time TC, obtain prepared liquid D; Step S8: filtering to prepare liquid D, obtaining filtrate B and medicinal residue B; Step S9: combining the filtrate A and the filtrate B to obtain a filtrate C; the filtrate C is a decoction for treating hyperlipidemia.

9. The method for preparing the decoction for treating hyperlipidemia according to claim 8, characterized in that: The method comprises: step S10: filtering and concentrating the filtrate to obtain a concentrated solution D, wherein the concentrated solution D is a decoction for treating hyperlipidemia.

10. The method for preparing the decoction for treating hyperlipidemia according to claim 8, characterized in that: The range of the set soaking time TA is 10 minutes to 20 minutes; the range of the set time TB is 15 minutes to 25 minutes; the range of the set time TC is 10 minutes to 20 minutes.

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