Device for mixing flower type lactose auxiliary materials and active pharmaceutical ingredients

Abstract

The invention relates to the technical field of mixing devices, in particular to a device for mixing flower type lactose auxiliary materials and active pharmaceutical ingredients. According to the technical scheme, the stirring device comprises a stirring bin and a stirring component installed in the stirring bin, the stirring bin is provided with a plurality of feeding ports, the stirring device further comprises a feeding component installed on the stirring bin and located on the feeding ports, the feeding component comprises a feeding box used for containing materials, and the feeding component controls the mass of the materials flowing out of the feeding box at a time. Through the mutual cooperation of the detection mechanism and the proportioning mechanism, the quality of the material passing through the feeding box at a time can be accurately controlled, so that the proportioning precision of the material can be improved, and the influence of the falling material in the material box on the proportioning is prevented.

Description

Technical Field

[0001] The invention relates to the technical field of mixing devices, in particular to a device for mixing flower-shaped lactose adjuvants and active drug ingredients. Background Art

[0002] The device for mixing the flower-shaped lactose excipient with the active pharmaceutical ingredient usually adopts efficient, closed stirring equipment, such as a twin-screw mixer. The twin-screw mixer has excellent mixing uniformity and small material loss. The method of using a twin-screw mixer for multiple step-feeding has many benefits in the pharmaceutical, food and chemical industries, such as improving the mixing uniformity. Through multiple step-feeding, the material can be more evenly distributed during the mixing process, especially when dealing with materials of different particle sizes or densities. Step-feeding helps to reduce stratification and segregation.

[0003] When feeding multiple times in a stepwise manner, each feeding needs to be done in proportion, which helps improve powder fluidity and promotes mixing with other ingredients. Multiple feeding in a stepwise manner helps ensure that the API is evenly distributed on the surface and in the gaps of the flower-shaped lactose, thereby improving the overall mixing uniformity. The proportion of the material can be controlled by controlling the mass of a single material delivery. Generally, the mass of the material in the feed box is monitored by a pressure sensor, but there is a certain distance between the feed port and the discharge port of the material box. The material that enters the feed box but does not contact the bottom of the feed box will not be detected by the pressure sensor. When the pressure sensor detects the specified value, even if the delivery of the material in the feed box is stopped immediately, there will be a part of the material falling in the material box. The presence of these materials will increase the mass of the material delivered in a single time, which is not conducive to accurate proportioning. Summary of the invention

[0004] The purpose of the present invention is to solve the problems existing in the background technology and to provide a device for mixing flower-shaped lactose excipients with active pharmaceutical ingredients.

[0005] The technical solution of the present invention is a device for mixing flower-shaped lactose excipients and active pharmaceutical ingredients, comprising a stirring chamber and a stirring component installed inside the stirring chamber, wherein the stirring chamber is provided with a plurality of feed ports, and further comprising:

[0006] A feeding component installed in the mixing bin and located on the feeding port, the feeding component includes a feeding box for accommodating materials, the feeding component controls the mass of materials flowing out of the feeding box at a single time, the feeding component includes a valve assembly for controlling whether the upper and lower sides of the feeding box are flowing, the feeding component includes a detection mechanism for detecting the mass of materials in the feeding box, and a proportioning mechanism for collecting excess materials in the feeding box.

[0007] Optionally, the stirring component includes a support frame rotatably installed in the stirring chamber, a driving shaft rotatably installed in the support frame, a first motor fixedly installed on the stirring chamber, an output shaft of the first motor is coaxially fixedly connected to the driving shaft, two transmission shafts rotatably installed in the support frame, a first bevel gear is fixedly installed on the bottom end of the driving shaft, a second bevel gear is fixedly installed on one end of the transmission shaft, and the second bevel gear is meshed with the first bevel gear, and stirring blades are rotatably installed at both ends of the support frame, a third bevel gear is fixedly installed on one end of the transmission shaft, a fourth bevel gear is fixedly installed on one end of the stirring blade, and the third bevel gear is meshed with the fourth bevel gear.

[0008] Optionally, a second motor is fixedly mounted on the support frame, a worm is rotatably mounted inside the support frame, a turbine is fixedly mounted on the support frame, an output shaft of the second motor is coaxially fixedly connected to the worm, and the worm and the turbine are meshed with each other.

[0009] Optionally, the feeding component includes a supporting box fixedly mounted on the feeding port, a first electrically-controlled valve fixedly mounted on the supporting box, a flow guide cover fixedly mounted on the first electrically-controlled valve, the feeding box being slidably mounted inside the supporting box, and the feeding box being connected to the first electrically-controlled valve via a telescopic tube.

[0010] Optionally, the valve assembly includes a first electrically-controlled valve, the valve assembly also includes a flow hole arranged at the bottom of a feed box, a plurality of support rods are fixedly mounted on the feed box, a sealing plate is slidably mounted on the support rods, the plurality of sealing plates are arranged in a circular array, the sealing plates are inclined, and the valve assembly also includes a power assembly for controlling the plurality of sealing plates to gather or spread together.

[0011] Optionally, the power assembly includes a plurality of connecting rods fixedly mounted on the feed box, a driving ring being rotatably mounted on the plurality of connecting rods, a plurality of connecting rods being rotatably mounted on the driving ring, the connecting rods corresponding one-to-one to the sealing plate and being rotatably connected, a third motor being fixedly mounted on the feed box, a driving gear being fixedly mounted on the output shaft of the third motor, a driven gear being fixedly mounted on the driving ring, and the driving gear and the driven gear being meshed with each other.

[0012] Optionally, the detection mechanism includes a plurality of first springs fixedly installed in a support box, the other end of the first spring is fixedly connected to the feed box, a plurality of first oil barrels are fixedly installed on the support box, a first pressure rod is slidably installed in the first oil barrel, a seal is provided between the first pressure rod and the first oil barrel, and the first pressure rod passes through the top of the first oil barrel and is fixedly connected to the feed box.

[0013] Optionally, the detection mechanism also includes a second oil barrel fixedly mounted on the support box, a second pressure rod is slidably mounted in the second oil barrel, a sealing treatment is provided between the second pressure rod and the second oil barrel, the second pressure rod passes through the top of the second oil barrel and is fixedly mounted with a first connecting disk, a second spring is fixedly mounted on the first connecting disk, a second connecting disk is fixedly mounted on the other end of the second spring, a pressure sensor is fixedly mounted on the output shaft of the support box, the pressure sensor is fixedly connected to the second connecting disk, and the upper and lower ends of the first oil barrels are connected to the upper and lower ends of the second oil barrels through oil pipes.

[0014] Optionally, the proportioning mechanism includes a collecting box slidably mounted on both sides of the feed box, two pulleys rotatably mounted in the collecting box, a transmission belt is sleeved on the two pulleys, a plurality of feeding plates are fixedly mounted on the transmission belt, a fourth motor is fixedly mounted on the collecting box, an output shaft of the fourth motor is coaxially fixedly connected to one of the pulleys, the feeding plate in one of the collecting boxes is larger than the feeding plate in the other collecting box, and a lifting and adjusting component is installed in the support box to control the bottom of the collecting box to contact the surface of the material inside the feed box.

[0015] Optionally, the lifting and adjusting assembly includes two third oil barrels fixedly installed in the support box, a third pressure rod is slidably installed in the third oil barrel, the third pressure rod corresponds to the collection box one-to-one and is fixedly connected, a first connecting pipe is fixedly installed on the third oil barrel, two pump bodies and a water tank are fixedly installed in the support box, the pump body corresponds to the first connecting pipe one-to-one, the output end of the pump body is connected to the first connecting pipe, and the input end of the pump body is connected to the water tank;

[0016] A second connecting pipe is fixedly installed on the third oil barrel, a one-way valve is fixedly installed on the second connecting pipe, a second electrically-controlled valve is fixedly installed on the one-way valve, and the second electrically-controlled valve is connected to the water tank through the third connecting pipe.

[0017] In summary, the present application includes at least one of the following beneficial technical effects:

[0018] The present invention can accurately control the quality of materials passing through the feed box at a single time through the cooperation of the detection mechanism and the proportioning mechanism, thereby improving the proportioning accuracy of the materials, preventing the falling materials in the material box from affecting the proportioning, and preventing the differences in the quantity of materials from being superimposed on each other during multiple feedings, thereby ensuring the accuracy of material proportioning adjustment during multiple conveyings. Conveying materials strictly according to the proportions can ensure that each batch of products has the same quality and effect, which is particularly important for medicines because the consistency of dosage is directly related to the therapeutic effect and safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 A structural schematic diagram of the mixing bin of the present invention is given;

[0020] Figure 2 It is a schematic diagram of the structure inside the mixing chamber;

[0021] Figure 3 It is a structural schematic diagram of a stirring component;

[0022] Figure 4 is the displacement relationship diagram of the feeding component;

[0023] Figure 5 This is a schematic diagram of the flow of materials into the collection box;

[0024] Figure 6 This is a schematic diagram of the location of the connection box;

[0025] Figure 7 It is a schematic diagram of the structure inside the support box of the present invention;

[0026] Figure 8 It is a structural schematic diagram of the sealing plate of the present invention;

[0027] Fig. 9 for Figure 8 A partial enlarged view of the middle A;

[0028] Fig.10 It is a schematic diagram of the overall structure of the feeding component;

[0029] Fig.11 A schematic diagram of the oil pipe connection between the first oil barrel and the second oil barrel;

[0030] Fig.12 It is a structural schematic diagram of the lifting and adjusting assembly of the present invention;

[0031] Fig.13 for Fig.13 A partial enlarged view of point B in the middle;

[0032] Fig.14 It is a connection schematic diagram of the transmission belt of the present invention;

[0033] Fig.15 Schematic diagram of the shape of the feeding plate.

[0034] 1. Mixing bin; 2. Mixing member; 201. Support frame; 202. Drive shaft; 203. First motor; 204. Transmission shaft; 205. First bevel gear; 206. Second bevel gear; 207. Mixing blade; 208. Third bevel gear; 209. Fourth bevel gear; 210. Second motor; 211. Worm; 212. Turbine; 3. Feed port; 4. Feed member; 401. Support box; 402. First electric control valve; 403. Guide cover; 404. Feed box; 405. Telescopic tube; 406. Support rod; 407. Closing plate; 408. Connecting rod; 409. Drive ring; 410. Connecting rod; 411. Third motor; 412. Driving gear; 413. Driven gear; 414. First a spring; 415, a first oil drum; 416, a first pressure rod; 417, a second oil drum; 418, a second pressure rod; 419, a first connecting plate; 420, a second spring; 421, a second connecting plate; 422, a pressure sensor; 423, a collecting box; 424, a pulley; 425, a transmission belt; 426, a material-retrieving plate; 427, a fourth motor; 428, a third oil drum; 429, a third pressure rod; 430, a first connecting pipe; 431, a pump body; 432, a water tank; 433, a second connecting pipe; 434, a one-way valve; 435, a second electrically-controlled valve; 436, a third connecting pipe; 5, a connecting box; 501, a vibration motor; 502, an eccentric block; 6, pressurized materials; 601, falling materials; 602, retained materials. DETAILED DESCRIPTION

[0035] The technical solution of the present invention is further described below in conjunction with the accompanying drawings and specific embodiments.

[0036] like Figures 1 to 15As shown, a device for mixing flower-shaped lactose excipients and active pharmaceutical ingredients proposed in the present invention comprises a stirring chamber 1 and a stirring component 2 installed inside the stirring chamber 1. The stirring component 2 can stir the material inside the stirring chamber 1. The stirring component 2 comprises a support frame 201 rotatably installed in the stirring chamber 1, a driving shaft 202 is rotatably installed in the support frame 201, a first motor 203 is fixedly installed on the stirring chamber 1, and the output shaft of the first motor 203 is coaxially fixedly connected with the driving shaft 202. Two transmission shafts 204 are rotatably installed, a first bevel gear 205 is fixedly installed on the bottom end of the driving shaft 202, a second bevel gear 206 is fixedly installed on one end of the transmission shaft 204, the second bevel gear 206 and the first bevel gear 205 are meshed with each other, stirring blades 207 are rotatably installed on both ends of the support frame 201, a third bevel gear 208 is fixedly installed on one end of the transmission shaft 204, a fourth bevel gear 209 is fixedly installed on one end of the stirring blade 207, and the third bevel gear 208 and the fourth bevel gear 209 are meshed with each other. When stirring, the first motor 203 is started to drive the driving shaft 202 to rotate, and the rotating driving shaft 202 will drive the first bevel gear 205 to rotate, and the rotating first bevel gear 205 will drive the second bevel gear 206 to rotate, thereby rotating the transmission shaft 204, and the rotating transmission shaft 204 will drive the two stirring blades 207 to rotate through the transmission of the third bevel gear 208 and the fourth bevel gear 209, and then the flower-shaped lactose excipients and the active pharmaceutical ingredients in the stirring chamber 1 are mixed through the stirring blades.

[0037] Furthermore, a second motor 210 is fixedly mounted on the support frame 201, a worm 211 is rotatably mounted in the support frame 201, a turbine 212 is fixedly mounted on the support frame 201, and the output shaft of the second motor 210 is coaxially fixedly connected with the worm 211, and the worm 211 and the turbine 212 are meshed with each other. The second motor 210 can drive the worm 211 to rotate, the rotating worm 211 can drive the turbine 212 to rotate, and the rotating turbine 212 can drive the support frame 201 to rotate, and then the two stirring blades 207 can be driven to rotate and turn around at the same time, thereby effectively improving the stirring efficiency and effect of the flower-shaped lactose excipient and the active pharmaceutical ingredient.

[0038] Among them, the stirring bin 1 is provided with a plurality of feed ports 3, so that the flower-shaped lactose excipients and active pharmaceutical ingredients are transported into the stirring bin 1 through different feed ports. In this embodiment, a feed component 4 is also installed in the stirring bin 1 and located on the feed port 3. The feed component 4 includes a feed box 404 for accommodating materials. The materials passing through the feed port 3 will enter the inside of the feed box 404. The feed component 4 controls the quality of the materials flowing out of the feed box 404 at a single time. The feed component 4 includes a valve assembly for controlling whether the upper and lower sides of the feed box 404 are flowing. The valve assembly can control whether the materials enter the feed box 404 and whether the materials can flow out of the feed box 404. The feed component 4 includes a detection mechanism for detecting the quality of the materials in the feed box 404 and a proportioning mechanism for collecting the excess materials in the feed box 404. Through the cooperation of the detection mechanism and the proportioning mechanism, the quality of the materials passing through the feed box 404 at a single time can be accurately controlled, thereby improving the proportioning accuracy of the materials.

[0039] Further, the feeding component 4 includes a support box 401 fixedly mounted on the feed port 3, a first electrically controlled valve 402 fixedly mounted on the support box 401, a flow guide 403 fixedly mounted on the first electrically controlled valve 402, and when the material is placed in the flow guide 403, the material will slide downward under the action of gravity, thereby allowing the material to enter and pass through the first electrically controlled valve 402, and a feed box 404 is slidably mounted inside the support box 401, and the feed box 404 is connected to the first electrically controlled valve 402 through a telescopic tube 405. When the material enters the feed box 404, the feed box 404 will move inside the support box 401, and the first electrically controlled valve 402 can be always connected to the feed box 404 through the telescopic tube 405 to prevent leakage of the material. The valve assembly includes a first electrically controlled valve 402, and whether the material can enter the feed box 404 can be controlled by controlling the opening and closing of the first electrically controlled valve 402. The valve assembly also includes a flow hole arranged at the bottom of the feed box 404, and a plurality of support rods 406 are fixedly installed on the feed box 404, and a sealing plate 407 is slidably installed on the support rod 406. The plurality of sealing plates 407 are arranged in a circular array, and the plurality of sealing plates 407 block the flow hole, and the sealing plates 407 are arranged obliquely. When the sealing plates 407 do not block the flow hole, the material inside the feed box 404 can be completely flowed out, and the valve core of the ordinary valve can be prevented from being stuck. The valve assembly also includes a power assembly for controlling the plurality of sealing plates 407 to gather or spread together. The power assembly can control whether the sealing plates 407 block the flow hole, and thus control whether the material can pass through the feed box 404.

[0040] Furthermore, the power assembly includes a plurality of connecting rods 408 fixedly mounted on the feed box 404, a driving ring 409 is rotatably mounted on the plurality of connecting rods 408, a plurality of connecting rods 410 are rotatably mounted on the driving ring 409, the connecting rods 410 correspond to the sealing plate 407 one by one and are rotatably connected, a third motor 411 is fixedly mounted on the feed box 404, a driving gear 412 is fixedly mounted on the output shaft of the third motor 411, a driven gear 413 is fixedly mounted on the driving ring 409, and the driving gear 412 and the driven gear 413 are meshed with each other. The third motor 411 can drive the driving gear 412 to rotate, and the rotating driving gear 412 can drive the driving ring 409 to rotate through the driven gear 413, and the rotating driving ring 409 will drive the connecting rod 410 to rotate, and the connecting rod 410 can pull the sealing plate 407 to move along the support rod 406, so that the multiple sealing plates 407 can be gathered or expanded. When the multiple sealing plates 407 expand with each other, gaps will appear between two adjacent sealing plates 407, and materials can flow out through these gaps. When the multiple sealing plates 407 are gathered together, the gaps between the sealing plates 407 will disappear, thereby preventing the material from flowing out of the feed box 404.

[0041] In this embodiment, the detection mechanism includes a plurality of first springs 414 fixedly installed in the support box 401, the other end of the first spring 414 is fixedly connected to the feed box 404, a plurality of first oil barrels 415 are fixedly installed on the support box 401, a first pressure rod 416 is slidably installed in the first oil barrel 415, a sealing treatment is provided between the first pressure rod 416 and the first oil barrel 415, and the first pressure rod 416 passes through the top of the first oil barrel 415 and is fixedly connected to the feed box 404. When the material in the feed box 404 gradually increases, the overall mass of the feed box 404 will gradually increase, at this time the feed box 404 will gradually squeeze the first spring 414 and move downward, and the downwardly moving feed box 404 will drive the first pressure rod 416 to move downward.

[0042] Furthermore, the detection mechanism also includes a second oil barrel 417 fixedly mounted on the support box 401, a second pressure rod 418 is slidably mounted in the second oil barrel 417, a sealing treatment is provided between the second pressure rod 418 and the second oil barrel 417, the second pressure rod 418 passes through the top of the second oil barrel 417 and is fixedly mounted with a first connecting disk 419, a second spring 420 is fixedly mounted on the first connecting disk 419, a second connecting disk 421 is fixedly mounted on the other end of the second spring 420, a pressure sensor 422 is fixedly mounted on the output shaft of the support box 401, the pressure sensor 422 is fixedly connected to the second connecting disk 421, and the upper and lower ends of the multiple first oil barrels 415 are connected to the upper and lower ends of the second oil barrel 417 through oil pipes.

[0043] It should be noted that the first oil barrel 415 and the second oil barrel 417 are both filled with hydraulic oil. When the feed box 404 drives the first pressure rod 416 to move downward, the hydraulic oil inside the first oil barrel 415 will be squeezed by the first pressure rod 416. At this time, the squeezed hydraulic oil will enter the bottom of the second oil barrel 417 through the oil pipe. At this time, the hydraulic oil that will enter the second oil barrel 417 will drive the second pressure rod 418 to rise, and then the second spring 420 can be squeezed through the first connecting plate 419, and then the material quality inside the feed box 404 can be detected by the pressure sensor.

[0044] It is worth noting that in order to ensure smooth flow at the bottom of the feed box 404, a sealing plate 407 needs to be set in the middle of the feed box 404. This results in the pressure sensor 422 being unable to be directly installed in the middle of the feed box 404, but can only be installed at the edge of the feed box 404. Such an installation method may cause deviations in the detection of the internal quality of the feed box 404, and the accuracy of the detection cannot be guaranteed. The setting of the detection mechanism can effectively prevent this problem from occurring, and the accuracy of the internal quality detection of the feed box 404 can be guaranteed while ensuring the fluidity of the feed box 404.

[0045] It should be noted that the reference Figure 5 , wherein the material pushed inside the feed box 404 and applying pressure to the feed box 404 is the pressurized material 6, and the material between the first electrically-controlled valve 402 and the surface of the pressurized material 6 is the falling material 601 that does not apply gravity to the feed box 404, and the material pushed on the first electrically-controlled valve 402 is the retained material 602 that cannot fall after the first electrically-controlled valve 402 is closed. When the material inside the feed box 404 reaches the specified pressure, the first electrically-controlled valve 402 is immediately closed. At this time, the falling material 601 is redundant material. When the material inside the feed box 404 is output, this part of the falling material 601 needs to be separated separately, so as to ensure the accuracy of the material ratio.

[0046] In this embodiment, the proportioning mechanism includes a collecting box 423 slidably installed on both sides of the feed box 404, and two pulleys 424 are rotatably installed in the collecting box 423. A transmission belt 425 is sleeved on the two pulleys 424, and a plurality of feeding plates 426 are fixedly installed on the transmission belt 425. A fourth motor 427 is fixedly installed on the collecting box 423, and the output shaft of the fourth motor 427 is coaxially fixedly connected to one of the pulleys 424. By starting the fourth motor 427, the pulley 424 can be driven to rotate, and the rotating pulley 424 will drive the transmission belt 425 to rotate, and the rotating transmission belt 425 will drive the plurality of feeding plates 426 to rotate. Through the L-shaped setting of the feeding plate 426, the feeding plate 426 can be used to feed the material inside the feed box 404, thereby preventing the excess material inside the feed box 404 from flowing out, and ensuring the accuracy of the proportioning.

[0047] It is worth noting that the material taking plate 426 in one of the collection boxes 423 is larger than the material taking plate 426 in the other collection box 423, and a lifting and adjusting assembly is installed in the support box 401 to control the bottom of the collection box 423 to contact the surface of the material inside the feed box 404. The mass of the material taken out by the larger material taking plate 426 at a time will be greater than the mass of the material taken out by the smaller material taking plate 426 at a time. When accurately proportioning, the larger material taking plate 426 needs to be rotated first, and the excess material is first taken out by the larger material taking plate 426, and then the rotation of the larger material taking plate 426 is stopped, and the smaller material taking plate 426 is rotated. The mass of the material can be accurately adjusted by the smaller material taking plate 426, and the larger material taking plate 426 and the smaller material taking plate 426 are used in combination to ensure the material taking accuracy and improve the material taking efficiency.

[0048] Furthermore, the lifting and adjusting assembly includes two third oil barrels 428 fixedly installed in the support box 401, and a third pressure rod 429 is slidably installed in the third oil barrel 428. The third pressure rod 429 corresponds to the collecting box 423 one by one and is fixedly connected. A first connecting pipe 430 is fixedly installed on the third oil barrel 428. Two pump bodies 431 and a water tank 432 are fixedly installed in the support box 401. The pump body 431 corresponds to the first connecting pipe 430 one by one. The output end of the pump body 431 is connected to the first connecting pipe 430, and the input end of the pump body 431 is connected to the water tank 432. A second connecting pipe 433 is fixedly installed on the third oil barrel 428, a one-way valve 434 is fixedly installed on the second connecting pipe 433, a second electrically-controlled valve 435 is fixedly installed on the one-way valve 434, and the second electrically-controlled valve 435 is connected to the water tank 432 through a third connecting pipe 436. The inside of the water tank 432 and the third oil barrel 428 are both filled with hydraulic oil. When the collecting box 423 needs to be raised, the hydraulic oil inside the water tank 432 needs to be transported to the inside of the third oil barrel 428 through the pump body 431. At this time, the third pressure rod 429 will be driven to rise under the action of the hydraulic oil, and then the collecting box 423 can be driven to rise through the third pressure rod 429. At this time, the second electrically controlled valve 435 is in a closed state, and the one-way valve 434 only allows the hydraulic oil to flow one way from the inside of the third oil barrel 428 to the inside of the water tank 432.

[0049] When it is necessary to take out the excess material inside the feed box 404, it is first necessary to make the bottom of the collecting box 423 contact with the surface of the material inside the feed box 404. At this time, the second electrically-controlled valve 435 is opened, so that the hydraulic oil inside the third oil barrel 428 will flow into the water tank 432 through the second electrically-controlled valve 435 under the action of gravity. At this time, the collecting box 423 can be lowered. When the bottom of the collecting box 423 contacts the material inside the feed box 404, the feed box 404 will be unable to move. At this time, the second electrically-controlled valve 435 is closed. At this time, the collecting box 423 is supported by the third pressure rod 429, and the collecting box 423 will not exert pressure on the feed box 404, so that the quality of the material inside the feed box 404 can be accurately adjusted. After the material is discharged from the feed box 404 and the multiple sealing plates 407 seal the feed box 404 , the transmission belt 425 can continue to rotate or reverse the transmission belt 425 to discharge the material inside the material taking plate 426 into the feed box 404 .

[0050] In this embodiment, two connecting boxes 5 are fixedly installed on the support box 401, and a vibration motor 501 is installed in the connecting box 5. An eccentric block 502 is eccentrically fixedly installed on the output shaft of the vibration motor 501. The eccentric block 502 is driven by the vibration motor 501 to rotate, so that the support box 401 and the feed box 404 can be vibrated, which can improve the smooth flow of materials when the materials enter the feed box 404 and when the materials flow out of the feed box 404, and can make the materials inside the feed box 404 in a flat state.

[0051] The working principle of this embodiment is as follows: when stirring is required, the first motor 203 is started to drive the two stirring blades 207 to rotate, and then the stirring blades are used to mix the flower-shaped lactose excipients and the active pharmaceutical ingredients inside the stirring chamber 1. The second motor 210 can drive the worm 211 to rotate, and the rotating worm 211 can drive the turbine 212 to rotate, and the rotating turbine 212 can drive the support frame 201 to rotate, and then the two stirring blades 207 can be driven to rotate and turn around at the same time, thereby effectively improving the stirring efficiency and effect of the flower-shaped lactose excipients and the active pharmaceutical ingredients.

[0052] By controlling the opening and closing of the first electric control valve 402, it is possible to control whether the material can enter the feed box 404. When the material in the feed box 404 gradually increases, the overall mass of the feed box 404 will gradually increase. At this time, the feed box 404 will gradually squeeze the first spring 414 and move downward. The downwardly moved feed box 404 will drive the first pressure rod 416 to move downward. The hydraulic oil in the first oil barrel 415 will be squeezed by the first pressure rod 416. At this time, the squeezed hydraulic oil will enter the bottom of the second oil barrel 417 through the oil pipe. At this time, the hydraulic oil that will enter the second oil barrel 417 will drive the second pressure rod 418 to rise, and then the second spring 420 can be squeezed through the first connecting plate 419, and then the quality of the material in the feed box 404 can be detected by the pressure sensor.

[0053] Further starting the fourth motor 427 can drive the pulley 424 to rotate, and the rotating pulley 424 will drive the transmission belt 425 to rotate, and the rotating transmission belt 425 will drive multiple feeding plates 426 to rotate. Through the L-shaped setting of the feeding plate 426, the feeding plate 426 can take the material inside the feed box 404, thereby preventing the excess material inside the feed box 404 from flowing out, and ensuring the accuracy of the ratio.

[0054] Then, the third motor 411 can drive the multiple sealing plates 407 to expand. When the multiple sealing plates 407 expand with each other, gaps will appear between two adjacent sealing plates 407, and the materials can flow out through the gaps.

[0055] The above specific embodiments are only several optional embodiments of the present invention. Based on the technical solutions of the present invention and the relevant inspirations of the above embodiments, those skilled in the art can make various alternative improvements and combinations to the above specific embodiments.

Claims

1. A device for mixing flower-shaped lactose excipients and active pharmaceutical ingredients, comprising a stirring chamber (1) and a stirring component (2) installed inside the stirring chamber (1), wherein the stirring chamber (1) is provided with a plurality of feed ports (3), characterized in that: Also includes: A feeding component (4) is installed on the mixing bin (1) and located on the feeding port (3), the feeding component (4) comprising a feeding box (404) for containing materials, the feeding component (4) controls the mass of materials flowing out of the feeding box (404) at a time, the feeding component (4) comprises a valve assembly for controlling whether the upper and lower sides of the feeding box (404) are flowing, and the feeding component (4) comprises a detection mechanism for detecting the mass of materials in the feeding box (404) and a proportioning mechanism for collecting excess materials in the feeding box (404).

2. The device for mixing flower-shaped lactose excipients and active pharmaceutical ingredients according to claim 1, characterized in that: The stirring component (2) comprises a support frame (201) rotatably mounted in the stirring chamber (1), a driving shaft (202) rotatably mounted in the support frame (201), a first motor (203) fixedly mounted on the stirring chamber (1), an output shaft of the first motor (203) being coaxially fixedly connected to the driving shaft (202), two transmission shafts (204) rotatably mounted in the support frame (201), a first bevel gear (205) fixedly mounted at the bottom end of the driving shaft (202), and the stirring chamber (1) being fixedly mounted with a first motor (203). A second bevel gear (206) is fixedly mounted on one end of the transmission shaft (204), and the second bevel gear (206) is meshed with the first bevel gear (205). A stirring blade (207) is rotatably mounted on both ends of the support frame (201). A third bevel gear (208) is fixedly mounted on one end of the transmission shaft (204), and a fourth bevel gear (209) is fixedly mounted on one end of the stirring blade (207), and the third bevel gear (208) is meshed with the fourth bevel gear (209).

3. The device for mixing flower-shaped lactose excipients and active pharmaceutical ingredients according to claim 2, characterized in that: A second motor (210) is fixedly mounted on the support frame (201), a worm (211) is rotatably mounted inside the support frame (201), a turbine (212) is fixedly mounted on the support frame (201), an output shaft of the second motor (210) is coaxially fixedly connected to the worm (211), and the worm (211) and the turbine (212) are meshed with each other.

4. The device for mixing flower-shaped lactose excipients and active pharmaceutical ingredients according to claim 1, characterized in that: The feeding component (4) includes a supporting box (401) fixedly mounted on the feeding port (3), a first electrically controlled valve (402) fixedly mounted on the supporting box (401), a flow guide cover (403) fixedly mounted on the first electrically controlled valve (402), the feeding box (404) slidably mounted inside the supporting box (401), and the feeding box (404) is connected to the first electrically controlled valve (402) via a telescopic tube (405).

5. The device for mixing flower-shaped lactose excipients and active pharmaceutical ingredients according to claim 4, characterized in that: The valve assembly includes a first electrically controlled valve (402), and the valve assembly also includes a flow hole arranged at the bottom of a feed box (404). A plurality of support rods (406) are fixedly installed on the feed box (404), and a sealing plate (407) is slidably installed on the support rods (406). The plurality of sealing plates (407) are arranged in a circular array, and the sealing plates (407) are inclined. The valve assembly also includes a power assembly for controlling the plurality of sealing plates (407) to gather or spread together.

6. The device for mixing flower-shaped lactose excipients and active pharmaceutical ingredients according to claim 5, characterized in that: The power assembly includes a plurality of connecting rods (408) fixedly mounted on a feed box (404), a driving ring (409) being rotatably mounted on the plurality of connecting rods (408), a plurality of connecting rods (410) being rotatably mounted on the driving ring (409), the connecting rods (410) corresponding one to one with the sealing plate (407) and being rotatably connected, a third motor (411) being fixedly mounted on the feed box (404), a driving gear (412) being fixedly mounted on the output shaft of the third motor (411), a driven gear (413) being fixedly mounted on the driving ring (409), and the driving gear (412) and the driven gear (413) being meshed with each other.

7. The device for mixing flower-shaped lactose excipients with active pharmaceutical ingredients according to claim 6, characterized in that: The detection mechanism includes a plurality of first springs (414) fixedly installed in a support box (401), the other end of the first spring (414) being fixedly connected to the feed box (404), a plurality of first oil barrels (415) being fixedly installed on the support box (401), a first pressure rod (416) being slidably installed in the first oil barrel (415), a sealing treatment being provided between the first pressure rod (416) and the first oil barrel (415), the first pressure rod (416) passing through the top of the first oil barrel (415) and being fixedly connected to the feed box (404).

8. The device for mixing flower-shaped lactose excipients with active pharmaceutical ingredients according to claim 7, characterized in that: The detection mechanism also includes a second oil barrel (417) fixedly mounted on the support box (401), a second pressure rod (418) being slidably mounted in the second oil barrel (417), a sealing treatment being provided between the second pressure rod (418) and the second oil barrel (417), the second pressure rod (418) passing through the top of the second oil barrel (417) and fixedly mounted with a first connecting disk (419), a second spring (420) being fixedly mounted on the first connecting disk (419), a second connecting disk (421) being fixedly mounted on the other end of the second spring (420), a pressure sensor (422) being fixedly mounted on the output shaft of the support box (401), the pressure sensor (422) being fixedly connected to the second connecting disk (421), and the upper and lower ends of the plurality of first oil barrels (415) and the upper and lower ends of the second oil barrels (417) being connected through oil pipes.

9. The device for mixing flower-shaped lactose excipients and active pharmaceutical ingredients according to claim 8, characterized in that: The proportioning mechanism comprises a collecting box (423) slidably mounted on both sides of the feed box (404), two pulleys (424) being rotatably mounted in the collecting box (423), a transmission belt (425) being sleeved on the two pulleys (424), a plurality of feeding plates (426) being fixedly mounted on the transmission belt (425), a fourth motor (427) being fixedly mounted on the collecting box (423), an output shaft of the fourth motor (427) being coaxially fixedly connected to one of the pulleys (424), a feeding plate (426) in one of the collecting boxes (423) being larger than a feeding plate (426) in another of the collecting boxes (423), and a lifting and adjusting component for controlling the bottom of the collecting box (423) to contact the surface of the material inside the feed box (404) being mounted in the supporting box (401).

10. The device for mixing flower-shaped lactose excipients and active pharmaceutical ingredients according to claim 9, characterized in that: The lifting and adjusting assembly comprises two third oil barrels (428) fixedly installed in the support box (401), a third pressure rod (429) is slidably installed in the third oil barrels (428), the third pressure rod (429) corresponds to the collection box (423) one by one and is fixedly connected, a first connecting pipe (430) is fixedly installed on the third oil barrel (428), two pump bodies (431) and a water tank (432) are fixedly installed in the support box (401), the pump body (431) corresponds to the first connecting pipe (430) one by one, the output end of the pump body (431) is connected to the first connecting pipe (430), and the input end of the pump body (431) is connected to the water tank (432); A second connecting pipe (433) is fixedly mounted on the third oil barrel (428), a one-way valve (434) is fixedly mounted on the second connecting pipe (433), a second electrically controlled valve (435) is fixedly mounted on the one-way valve (434), and the second electrically controlled valve (435) is connected to the water tank (432) via a third connecting pipe (436).

Images