Multi-index time-resolved fluorescence immunochromatography kidney injury detection kit
By designing a multi-index time-resolved fluorescence immunochromatography renal injury detection kit, multiple sets of reagent strips and driving components are used to achieve flexible movement of reagent strips, solving the problem that multi-index detection cannot be completed simultaneously in a single sample solution in the prior art, improving the accuracy and specificity of the detection, and simplifying the operation process.
Patent Information
- Application Number
- CN202510052428.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-14
- Publication Date
- 2025-03-11
AI Technical Summary
The existing renal injury detection kits are difficult to complete multi-indicator testing in a single sample solution at the same time, and it is inconvenient to obtain and detect multiple reagent strips, which increases operational complexity and time cost.
A multi-index time-resolved fluorescent immunochromatography renal injury detection kit is designed, which includes multiple sets of first reagent strips and second reagent strips. The flexible movement and detection of reagent strips are achieved through the driving assembly and the dropping table, allowing the detection of multiple key markers to be quickly completed in the same sample.
It realizes the simultaneous completion of multi-indicator testing in a single sample fluid, improves the accuracy and specificity of the detection, simplifies the operation process, reduces the detection cost, and supports early diagnosis and condition monitoring.
Smart Images

Figure CN119595892A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of kidney injury detection kits, in particular to a multi-index time-resolved fluorescent immunochromatography kidney injury detection kit. Background Art
[0002] Acute Kidney Injury (AKI) is a syndrome frequently encountered in clinical settings, characterized by rapid deterioration of kidney function and accumulation of metabolic waste in the body. Traditionally, the diagnosis of AKI mainly relies on the increase in serum creatinine (Scr) concentration and the decrease in urine volume as indicators. With the development of medical technology, the incidence of AKI has increased year by year, especially in hospitalized patients, especially those in intensive care units, whose risk of death has increased significantly. In view of this severe situation, it is particularly important to develop more efficient and accurate diagnostic tools.
[0003] The kidney injury detection kits currently on the market have limited internal filtration structures or membrane selective permeability, making it difficult to efficiently and selectively separate specific components from the sample solution for accurate testing. This limitation not only affects the detection accuracy of the kit for a single analyte, but also limits its ability to simultaneously complete multi-index detection in a single sample solution. Therefore, in order to evaluate different biomarkers, it is often necessary to use a variety of dedicated reagent strips for separate testing. However, it is inconvenient to take and test a variety of reagent strips, which easily increases the complexity and time cost of the operation, and also increases the overall testing cost. Summary of the invention
[0004] In view of the above problems or problems existing in the prior art, the present invention is proposed.
[0005] Therefore, the purpose of the present invention is to provide a multi-index time-resolved fluorescent immunochromatographic renal injury detection kit, which can solve the problem of the inability to simultaneously complete multi-index detection in a single sample liquid and the problem of the inconvenience of taking and testing multiple reagent strips.
[0006] In order to solve the above technical problems, the present invention provides the following technical solutions: a multi-index time-resolved fluorescent immunochromatographic renal injury detection kit, comprising a box body, including a storage end, a detection end arranged at one side of the storage end, a driving slot arranged at both sides of the detection end, a driving cap arranged at one side of the driving slot, and a sealing cover arranged at the end of the storage end;
[0007] The detection unit includes a plurality of first reagent strips arranged on the inner side of the storage end, a second reagent strip arranged on one side of the first reagent strip, a mounting plate arranged on the inner side of the detection end, a driving assembly slidably arranged on the inner side of the mounting plate, and a dripping table snap-fitted to the end of the detection end.
[0008] As a preferred embodiment of the multi-index time-resolved fluorescent immunochromatographic renal injury detection kit of the present invention, the storage end includes a first storage room arranged on one side thereof, and a second storage room arranged on the other side thereof;
[0009] The first reagent strip is arranged inside the first storage room; and the second reagent strip is arranged inside the second storage room.
[0010] As a preferred embodiment of the multi-indicator time-resolved fluorescent immunochromatographic renal injury detection kit of the present invention, the driving groove includes a transverse groove arranged on one side thereof, a limiting groove arranged at the upper end of the transverse groove, and an inclined groove arranged at the end of the limiting groove.
[0011] As a preferred embodiment of the multi-indicator time-resolved fluorescent immunochromatographic renal injury detection kit of the present invention, the dripping platform includes a plurality of dripping holes arranged through the end thereof, and an extraction groove opened on one side of the end thereof.
[0012] As a preferred embodiment of the multi-index time-resolved fluorescent immunochromatographic renal injury detection kit of the present invention, the sealing cover comprises a spring arranged at the bottom thereof, and a lower pressing plate arranged at the bottom of the spring;
[0013] The first storage room includes a first elastic sheet arranged at the bottom thereof, and a second elastic sheet arranged at the bottom of the second storage room.
[0014] As a preferred embodiment of the multi-indicator time-resolved fluorescent immunochromatographic renal injury detection kit of the present invention, the mounting plate comprises a middle driving plate arranged on the inner side thereof, and vertical plates arranged on both sides of the driving plate;
[0015] The driving assembly includes a first transport member mounted on the end of the driving plate and a second transport member arranged on both sides of the vertical plate.
[0016] As a preferred embodiment of the multi-index time-resolved fluorescent immunochromatographic renal injury detection kit of the present invention, the vertical plate includes a chute running through one side thereof, and a transport chute opened at the end of the chute;
[0017] The second transport member includes a second adsorption plate connected to the bottom of the second reagent strip, and connecting rods arranged on both sides of the second adsorption plate;
[0018] The connecting rod is slidably connected in the transport groove.
[0019] As a preferred solution of the multi-indicator time-resolved fluorescent immunochromatographic renal injury detection kit described in the present invention, the first transport member includes a moving plate slidably connected to the end of the driving plate, a moving member arranged on the inner side of the moving plate, and sliding rods arranged on both sides of the moving member.
[0020] As a preferred embodiment of the multi-indicator time-resolved fluorescent immunochromatographic renal injury detection kit of the present invention, the movable part includes a first adsorption plate arranged at the bottom of the first reagent strip, a lifting rod arranged at the bottom of the first adsorption plate, and a roller arranged at the bottom of the lifting rod.
[0021] As a preferred embodiment of the multi-indicator time-resolved fluorescent immunochromatographic renal injury detection kit of the present invention, a moving groove is provided on the driving plate, and the moving groove includes oblique grooves on both sides thereof and a low groove arranged on the inner side of the oblique groove.
[0022] Beneficial effects of the present invention: The two sets of drive caps in this device respectively drive the roller and the connecting rod to slide along the specified path, which simplifies the operation process and allows the tester to flexibly adjust the position of the reagent strip as needed. The tester can use the adsorption tube to drip the sample liquid on the dripping hole in turn, and let the sample liquid chromatograph on the corresponding reagent strip for detection. By comparing the indicators on the dripping table, the scope of damage can be judged more accurately. When the test results show that further verification is required, the reagent strip can be easily replaced through the extraction slot, thereby achieving repeated detection within the range of different markers and ensuring the reliability of the results. BRIEF DESCRIPTION OF THE DRAWINGS
[0023] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.
[0024] Figure 1 It is the overall structure diagram of the present invention.
[0025] Figure 2 It is a cross-sectional view of the internal structure of the box body of the present invention.
[0026] Figure 3 It is a schematic diagram of the structure of the detection unit in the present invention.
[0027] Figure 4 It is an exploded schematic diagram of the detection unit structure of the present invention.
[0028] Figure 5 It is a partial cross-sectional schematic diagram of the drive assembly structure of the present invention.
[0029] Figure 6 This is a diagram showing the movement trajectories of the first reagent strip and the second reagent strip of the present invention.
[0030] In the figure: 1, box body; 11, storage end; 12, detection end; 13, drive slot; 14, drive cap; 15, sealing cover; 2, detection unit; 21, first reagent strip; 22, second reagent strip; 23, mounting plate; 24, drive assembly; 25, dropper; 111, first storage room; 112, second storage room; 131, horizontal slot; 132, limit slot; 133, inclined slot; 151, spring; 152, lower pressure plate; 231, drive plate; 232, vertical plate; 241, first transport Part; 242, second transport part; 251, drip hole; 252, extraction groove; 1111, first spring piece; 1121, second spring piece; 2311, moving groove; 2321, slide groove; 2322, transport groove; 2411, moving plate; 2412, moving part; 2413, slide rod; 2421, second adsorption plate; 2422, connecting rod; 24121, first adsorption plate; 24122, lifting rod; 24123, roller; 23111, oblique groove; 23112, low groove. DETAILED DESCRIPTION
[0031] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the accompanying drawings.
[0032] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein, and those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.
[0033] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The term "in one embodiment" that appears in different places in this specification does not necessarily refer to the same embodiment, nor is it a separate or selective embodiment that is mutually exclusive with other embodiments.
[0034] Example 1
[0035] Reference Figure 1 to Figure 6 , which is the first embodiment of the present invention, and provides a multi-index time-resolved fluorescent immunochromatographic renal injury detection kit, which includes a box body 1, including a storage end 11, a detection end 12 arranged at one side of the storage end 11, a driving slot 13 arranged at both sides of the detection end 12, a driving cap 14 arranged at one side of the driving slot 13, and a sealing cover 15 arranged at the end of the storage end 11;
[0036] The detection unit 2 includes a plurality of first reagent strips 21 arranged on the inner side of the storage end 11, a second reagent strip 22 arranged on one side of the first reagent strip 21, a mounting plate 23 arranged on the inner side of the detection end 12, a driving assembly 24 slidably arranged on the inner side of the mounting plate 23, and a dripping table 25 snap-fitted to the end of the detection end 12.
[0037] Furthermore, the storage end 11 includes a first storage room 111 disposed on one side thereof, and a second storage room 112 disposed on the other side thereof;
[0038] The first reagent bar 21 is arranged inside the first storage room 111 ; and the second reagent bar 22 is arranged inside the second storage room 112 .
[0039] Furthermore, the driving slot 13 includes a transverse slot 131 disposed on one side thereof, a limiting slot 132 disposed at an upper end of the transverse slot 131 , and an inclined slot 133 disposed at an end of the limiting slot 132 .
[0040] Furthermore, the dripping platform 25 includes a plurality of dripping holes 251 penetratingly disposed at the end thereof, and a withdrawal groove 252 opened at one side of the end thereof.
[0041] Furthermore, the sealing cover 15 includes a spring 151 disposed at the bottom thereof, and a lower pressing plate 152 disposed at the bottom of the spring 151;
[0042] The first storage room 111 includes a first elastic sheet 1111 disposed at the bottom thereof, and a second elastic sheet 1121 disposed at the bottom of the second storage room 112 .
[0043] It should be noted that the box body 1 is an L-shaped box body, and is divided into two spaces. The rectangular slot column convexly arranged at the end position of the box body 1 is a storage end 11, and different types of reagent strips can be stored and placed in its inner side, avoiding physical contact and cross interference between the reagent strips. And the bottom of the storage end 11 is a detection end 12, and the detection end 12 can slide the different types of reagent strips from the inner side of the storage end 11 to the bottom of the dripping platform 25, so that the detection personnel can drip the kidney sample liquid on different reagent strips at the same time. In addition, two groups of symmetrically arranged drive grooves 13 are opened on the side walls of the detection end 12, and the drive groove 13 is fixedly connected to the drive assembly 24 inside the drive cap 14 to provide active limited space. And the end snap-on connection sealing cover 15 at the storage end 11.
[0044] Preferably, the storage end 11 has two storage spaces separated on its inner side, the outer side of which is the first storage room 111 for storing the first reagent strip 21; the inner side is the second storage room 112 for storing the second reagent strip 22. The first reagent strip 21 and the second reagent strip 22 have different internal filtration structures or membrane selective permeabilities, and can perform chromatographic detection on the renal sample fluid respectively, and each reagent strip is optimized specifically for a group of specific biomarkers to achieve more efficient detection. Among them, the first reagent strip 21 can detect early acute kidney injury AKI markers, such as neutrophil gelatinase-associated lipocalin, renal injury molecules, and interleukins; the second reagent strip 22 can detect comprehensive renal function assessment markers, such as serum creatinine, cystatin, urine microalbumin, α1-microglobulin and β2-microglobulin β, and retinol binding protein. This grouping detection method not only improves the accuracy of the detection, but also makes clinical application more flexible and can better meet the needs of different scenarios. It can avoid possible cross reactions between different markers and improve detection specificity. It also allows for rapid testing of multiple key markers in the same sample, thereby providing more accurate and timely diagnostic information.
[0045] Preferably, the bottom of the sealing cover 15 is fixedly connected with a plurality of groups of springs 151, and a group of lower pressing plates 152 are fixedly connected to the bottom of the springs 151. The lower pressing plates 152 act on the first reagent strips 21 and the second reagent strips 22, so as to always press down the first reagent strips 21 arrayed inside the first storage room 111 and the second reagent strips 22 arrayed inside the second storage room 112, so as to facilitate the delivery of the reagent strips to the detection end 112.
[0046] Preferably, the first storage room 111 has a first spring piece 1111 protruding from the bottom thereof, and the second storage room 112 also has a second spring piece 1121 protruding from the bottom thereof. The first spring piece 1111 and the second spring piece 1121 can lift the first reagent strip 21 and the second reagent strip 22 at their upper ends. The first spring piece 1111 and the second spring piece 1121 are respectively arranged on one side of the first storage room 111 and the second storage room 112, and the reagent strips are wrapped and lifted upward by the four sides of the first storage room 111 and the second storage room 112, so that the reagent strips can be taken out from the side where no spring piece is arranged.
[0047] Preferably, the driving groove 13 is provided through the side walls of the detection end 12, and is in the shape of a transverse groove 131 provided through the bottom, and the transverse groove 131 is used to drive the first reagent strip 21 inside the detection end 12 to move. A limiting groove 132 is provided at the end of the transverse groove 131, and an oblique groove 133 is provided at the end of the limiting groove 132; wherein the limiting groove 132 and the oblique groove 133 are used to move the second reagent strip 22 inside the detection end 12.
[0048] Preferably, the dripping platform 25 is a detection table, and the kidney sample liquid can be dripped on the dripping platform 25. The dripping platform 25 is fixedly mounted on the end face of the detection end 12 by the side wall buckle mode. On the surface of the dripping platform 25, there are multiple groups of dripping holes 251 that match the first reagent strip 21 and the second reagent strip 22 at its bottom, and the surface also has sample standard marks, and the sample standard marks of the first reagent strip 21 and the second reagent strip 22 and its corresponding upper end are compared and analyzed. And a withdrawal groove 252 is provided on one side of the dripping platform 25, and the withdrawal groove 252 can be avoided, so that the detection personnel directly contact the first reagent strip 21 and the second reagent strip 22 at its bottom, and the first reagent strip 21 and the second reagent strip 22 are taken away by pressing the withdrawal mode, which is convenient for the next detection and use.
[0049] In summary, the classified detection of the first reagent strip 21 and the second reagent strip 22 of the device can improve the accuracy of the detection, reduce the cross-reaction between different markers, and improve the detection specificity. It also allows the rapid completion of the detection of multiple key markers in the same sample, thereby providing more accurate and timely diagnostic information, supporting early diagnosis and disease monitoring. It improves the efficiency and accuracy of multi-index time-resolved fluorescence immunochromatography renal injury detection, and greatly enhances the convenience and flexibility of operation, providing strong support for clinical diagnosis.
[0050] Example 2
[0051] Reference Figure 1 to Figure 6 , which is the second embodiment of the present invention, and which is different from the first embodiment in that: the mounting plate 23 also includes a driving plate 231 disposed in the middle of the inner side thereof, and vertical plates 232 disposed on both sides of the driving plate 231;
[0052] The driving assembly 24 includes a first transporting member 241 mounted on an end of the driving plate 231 and a second transporting member 242 disposed on both sides of the vertical plate 232 .
[0053] Furthermore, the vertical plate 232 includes a slide groove 2321 extending through one side thereof, and a transport groove 2322 provided at the end of the slide groove 2321;
[0054] The second transport member 242 includes a second adsorption plate 2421 connected to the bottom of the second reagent strip 22 and connecting rods 2422 disposed on both sides of the second adsorption plate 2421;
[0055] The connecting rod 2422 is slidably connected in the transport groove 2322 .
[0056] Furthermore, the first transporting member 241 includes a moving plate 2411 slidably engaged with the end of the driving plate 231 , a moving member 2412 disposed on the inner side of the moving plate 2411 , and sliding rods 2413 disposed on both sides of the moving member 2412 .
[0057] Furthermore, the moving member 2412 includes a first adsorption plate 24121 disposed at the bottom of the first reagent strip 21 , a lifting rod 24122 disposed at the bottom of the first adsorption plate 24121 , and a roller 24123 disposed at the bottom of the lifting rod 24122 .
[0058] Furthermore, a moving groove 2311 is formed on the driving plate 231 , and the moving groove 2311 includes oblique grooves 23111 on both sides thereof and a low groove 23112 disposed inside the oblique groove 23111 .
[0059] It should be noted that the mounting plate 23 is fixedly connected to the bottom of the detection end 12. The mounting plate 23 is in the shape of a channel steel, and the vertical plates arranged on both sides thereof provide the required trajectory for the movement of the device. The vertical plate in the middle of the mounting plate 23 is a driving plate 231, and a moving groove 2311 is provided on the driving plate 231 to move the first reagent strip 21; the vertical plates are arranged in a fixed array on both sides of the driving plate 231 to hold the first reagent strip 21 and the second reagent strip 22 above the mounting plate 23. In addition, the outer side of the mounting plate 23 is a vertical plate 232, and a slide groove 2321 and a transport groove 2322 are also arranged on the vertical plate 232. The transport groove 2322 can provide a motion trajectory for the movement of the second reagent strip 22.
[0060] Preferably, a first transport member 241 is slidably disposed inside the moving groove 2311 on the driving plate 231, and a second transport member 242 is slidably connected inside the transport groove 2322 on the vertical plate 232. The movement of the first transport member 241 and the movement of the second transport member 242 do not interfere with each other, so that the testing personnel can call the first reagent strip 21 or the second reagent strip 22 separately according to the testing requirements.
[0061] Preferably, the first transport member 241 is composed of a moving plate 2411 slidably connected to the end of the driving plate 231, a moving member 2412 arranged inside the moving groove 2311, and a slide bar 2413 slidably connected to both sides of the moving member 2412. The moving plate 2411 is connected to the side of the driving plate 231 by slidingly connecting the notches on the lower side of the plate body. Two groups of through grooves are provided on the moving plate 2411, and the rod body of the lifting rod 24122 in the moving member 2412 is slidably connected in the through grooves. The lifting rod 24122 is divided into two groups, and the lower end thereof is hinged on both sides of the roller 24123, and the roller 24123 is hinged to the inner side of the moving groove 2311. The sliding rod 2413 is fixedly connected to the outer side of the lifting rod 24122 by means of a rod neck sleeve. A set of first adsorption plates 24121 are fixedly connected to the end of the lifting rod 24122. The first adsorption plates 24121 adsorb the first reagent strip 21 by magnetic attraction. Similarly, the second adsorption plates 2421 also adsorb the second reagent strip 22 by magnetic attraction.
[0062] Preferably, the roller 24123 is made of rubber and is slidably connected to the inner side of the moving groove 2311, and the lifting rod 24122 is a two-section plastic cylindrical structure, the bottom of which is an arc rod with a smaller rod diameter hinged on both sides of the roller 24123, and the upper end is a straight rod with a larger rod diameter, and the two are plugged together. The rod diameter of the sliding rod 2413 is sleeved on the lifting rod 24122, and its sleeve end is a three-way pipe sleeve, which is convenient for sliding sleeved on the lifting rod 24122.
[0063] Preferably, the second transport member 242 is composed of a second adsorption plate 2421 and a connecting rod 2422 fixedly connected to both sides of the second adsorption plate 2421. The connecting rod 2422 is slidably connected to the transport groove 2322, and the outer wall of the vertical plate 232 is attached to the inner wall of the detection end 12, and the slot path of the transport groove 2322 is consistent with the slot path of the limit groove 132 and the inclined groove 133. The connecting rod 2422 extends outward from the outside of the inclined groove 133 and is connected to the driving cap 14. The driving cap 14 is a special structure, one end of which is connected to the limit groove 132 and the other side is connected to the connecting rod 2422. Under the cooperation of the driving cap 14, the limit groove 132 and the inclined groove 133, the second adsorption plate 2421 cannot be flipped during the movement, thereby maintaining the second reagent strip 22 at the upper end of the second adsorption plate 2421 stable.
[0064] Among them, the moving groove 2311 is composed of three sections of slot paths, and the one facing the bottom of the first reagent strip 21 group is an oblique groove 23111 at one end, and the slope of the oblique groove 23111 is relatively large, which can make the roller 24123 slide downward quickly to avoid motion interference with the second reagent strip 22 inside the second storage room 112; and one side of the oblique groove 23111 is a low-level groove 23112, which is located directly below the second storage room 112. When the roller 24123 moves to the low-level groove 23112 section, it will pass under the second storage room 112 and will not interfere with the second transport member 242 in motion. The rear half of the low-level groove 23112 is also an oblique groove 23111, which can transport the roller 24123 from the bottom to the upper position. When the roller 24123 moves from the oblique slot 23111 to the low slot 23112 and then to the oblique slot 23111, it will pass through the following process: Figure 6The abc interval shown in the figure can move the first reagent strip 21 inside the first storage room 111 to the lower part of the outermost side of the dripping table 25. The transport groove 2322 on the vertical plate 232 is a path of an oblique groove first and then a straight groove, which can move the second reagent strip 22 inside the second storage room 112 to the lower part of the inner side of the dripping table 25. The horizontal position of the first spring piece 1111 is lower than the horizontal position of the second spring piece 1121, so that the first reagent strip 21 on the upper side of the first spring piece 1111 follows the roller 24123 at the bottom thereof along the oblique groove 23111 without being interfered by the second storage room 112, and the second reagent strip 22 on the second spring piece 1121 follows the movement of the second adsorption plate 2421 without being affected.
[0065] When in use, the inspector first pushes the two sets of drive caps 14 in the drive slot 13, so that one set of drive caps 14 drives the roller 24123 to move along the moving slot 2311, and the slide bar 2413 slides along the transverse slot 131; the other set of drive caps 14 slides along the limit slot 132 and the inclined slot 133, and then drives the inner connecting rod 2422 to slide along the transport slot 2322. The first reagent strip 21 and the second reagent strip 22 are moved to the bottom of the dripping table 25 as required, and the inspector can use the adsorption tube to drop the kidney sample liquid on the dripping hole 251 in turn, and let the sample liquid be chromatographed on the first reagent strip 21 and the second reagent strip 22 respectively, and the damage range can be judged by comparing the indicators on the dripping table 25.
[0066] When a test result is different from the marker resolution range on the first reagent strip 21 but is within the marker resolution range of the second reagent strip 22, the second reagent strip 22 can be removed from the removal slot 252 so that the second reagent strip 22 can be replaced and re-tested, and vice versa.
[0067] In summary, the device has two sets of drive caps 14 that respectively drive the roller 24123 and the connecting rod 2422 to slide along the specified path, which simplifies the operation process and allows the tester to flexibly adjust the position of the reagent strip as needed. The tester can use the adsorption tube to drip the sample liquid on the dripping hole 251 in sequence, and let the sample liquid chromatograph on the corresponding reagent strip for detection. By comparing the indicators on the dripping table, the scope of damage can be judged more accurately. When the test results show that further verification is required, the reagent strip can be easily replaced through the extraction slot 252, thereby achieving repeated detection within the range of different markers and ensuring the reliability of the results.
[0068] It is important to note that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.
Claims
1. A multi-index time-resolved fluorescence immunochromatography renal injury detection kit, characterized in that: include, A box body (1) comprises a storage end (11), a detection end (12) arranged at one side of the storage end (11), a driving groove (13) arranged at both sides of the detection end (12), a driving cap (14) arranged at one side of the driving groove (13), and a sealing cover (15) arranged at the end of the storage end (11); The detection unit (2) comprises a plurality of first reagent strips (21) arranged inside the storage end (11), a second reagent strip (22) arranged on one side of the first reagent strips (21), a mounting plate (23) arranged inside the detection end (12), a driving assembly (24) slidably arranged inside the mounting plate (23), and a dripping table (25) clamped and arranged at the end of the detection end (12).
2. The multi-index time-resolved fluorescence immunochromatography renal injury detection kit according to claim 1, characterized in that: The storage end (11) comprises a first storage room (111) arranged on one side thereof, and a second storage room (112) arranged on the other side thereof; The first reagent bar (21) is arranged inside the first storage room (111); and the second reagent bar (22) is arranged inside the second storage room (112).
3. The multi-index time-resolved fluorescence immunochromatography renal injury detection kit according to claim 2, characterized in that: The driving groove (13) comprises a transverse groove (131) arranged on one side thereof, a limiting groove (132) arranged at the upper end of the transverse groove (131), and an inclined groove (133) arranged at the end of the limiting groove (132).
4. The multi-index time-resolved fluorescence immunochromatography renal injury detection kit according to claim 3, characterized in that: The liquid dripping platform (25) comprises a plurality of dripping holes (251) penetratingly arranged at its end, and a withdrawal groove (252) opened at one side of its end.
5. The multi-index time-resolved fluorescence immunochromatography renal injury detection kit according to claim 4, characterized in that: The sealing cover (15) comprises a spring (151) arranged at the bottom thereof, and a lower pressing plate (152) arranged at the bottom of the spring (151); The first storage room (111) comprises a first elastic sheet (1111) arranged at the bottom thereof, and a second elastic sheet (1121) arranged at the bottom of the second storage room (112).
6. The multi-index time-resolved fluorescence immunochromatography renal injury detection kit according to claim 5, characterized in that: The mounting plate (23) comprises a driving plate (231) arranged in the middle of the inner side thereof, and vertical plates (232) arranged on both sides of the driving plate (231); The driving assembly (24) comprises a first transport member (241) mounted on the end of the driving plate (231) and a second transport member (242) arranged on both sides of the vertical plate (232).
7. The multi-index time-resolved fluorescence immunochromatography renal injury detection kit according to claim 6, characterized in that: The vertical plate (232) includes a slide groove (2321) penetratingly arranged on one side thereof, and a transport groove (2322) opened at the end of the slide groove (2321); The second transport member (242) comprises a second adsorption plate (2421) connected to the bottom of the second reagent strip (22), and connecting rods (2422) arranged on both sides of the second adsorption plate (2421); The connecting rod (2422) is slidably connected in the transport groove (2322).
8. The multi-index time-resolved fluorescence immunochromatography renal injury detection kit according to claim 7, characterized in that: The first transport member (241) comprises a moving plate (2411) slidably engaged with the end of the driving plate (231), a moving member (2412) disposed inside the moving plate (2411), and sliding rods (2413) disposed on both sides of the moving member (2412).
9. The multi-index time-resolved fluorescence immunochromatography renal injury detection kit according to claim 8, characterized in that: The moving member (2412) includes a first adsorption plate (24121) disposed at the bottom of the first reagent strip (21), a lifting rod (24122) disposed at the bottom of the first adsorption plate (24121), and a roller (24123) disposed at the bottom of the lifting rod (24122).
10. The multi-attribute time-resolved fluorescence immunochromatography renal injury detection kit according to claim 9, characterized in that: The driving plate (231) is provided with a moving groove (2311), and the moving groove (2311) includes oblique grooves (23111) on both sides thereof and a low groove (23112) arranged inside the oblique groove (23111).
Citation Information
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