Traditional Chinese medicine plaster for treating gouty arthritis and preparation method thereof

Abstract

The invention relates to the technical field of gouty arthritis, and discloses a traditional Chinese medicine plaster for treating gouty arthritis and a preparation method thereof. The ointment comprises the following materials: 1 part of paniculate swallowwort root, 1 part of asarum, 1 part of borneol, 2 parts of costustoot, 2 parts of earthworm, 3 parts of ligusticum wallichii, 3 parts of radix clematidis, 3 parts of spina gleditsiae, 4 parts of raw rhubarb, 6 parts of mint, a proper amount of vaseline, a proper amount of sesame oil, a medical dressing plaster and a desensitization adhesive tape. According to the traditional Chinese medicine plaster for treating the gouty arthritis and the preparation method of the traditional Chinese medicine plaster, the traditional Chinese medicine plaster directly acts on an affected part, transdermal absorption is achieved, the local treatment effect can be rapidly achieved, pains and inflammations caused by the gouty arthritis are relieved, medicinal materials are smashed into ultra-micro powder of 300 meshes through an ultra-micro powder machine, and the traditional Chinese medicine plaster is prepared into the traditional Chinese medicine plaster for treating the gouty arthritis. Compared with an oral medicine, the external plaster can increase the surface area of the medicine and improve the permeability and absorption efficiency of the medicine, and compared with the oral medicine, the external plaster can reduce the stimulation of the medicine to gastrointestinal tracts and systemic side effects.

Description

Technical Field

[0001] The invention relates to the technical field of gouty arthritis, in particular to a traditional Chinese medicine plaster for treating gouty arthritis and a preparation method thereof. Background Art

[0002] Acute gouty arthritis is caused by abnormal purine metabolism leading to excessive uric acid production or uric acid excretion disorder. The uric acid concentration in the body is too high, and urate crystals are deposited in the joints, stimulating the body's inflammatory factors and causing nonspecific inflammatory reactions such as joint pain and swelling.

[0003] During the acute attack of gout, the treatment goal is to quickly relieve the patient's pain. Modern medicine recommends the use of NSAIDs, colchicine, and glucocorticoids. Although the patient's clinical symptoms can be effectively controlled, the side effects of drugs such as nausea, vomiting, gastrointestinal bleeding, and liver and kidney damage cannot be ignored. Traditional Chinese medicine has the characteristics of multi-pathway, multi-level, and multi-target in acute gouty arthritis, and is generally safe and effective with low side effects.

[0004] Therefore, it is particularly important to seek a traditional Chinese medicine treatment method that is effective, safe, and simple and easy to use. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention provides a Chinese medicine plaster for external use for treating acute gouty arthritis and a preparation method thereof. The method is simple to operate, is not absorbed through the gastrointestinal tract, has high patient acceptance and good safety.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] A traditional Chinese medicine plaster for treating gouty arthritis and a preparation method thereof. The material composition of the plaster is 1 part of Cynanchum cyrtonema, 1 part of Asarum, 1 part of Borneolum, 2 parts of Aucklandia lappa, 2 parts of Pheretima, 3 parts of Chuanxiong, 3 parts of Clematidis, 3 parts of Gleditsia sinensis, 4 parts of Rhubarb, 6 parts of Menthus, an appropriate amount of Vaseline, an appropriate amount of sesame oil, a medical dressing and a desensitizing adhesive tape.

[0008] As a further solution of the present invention: the preparation process includes crushing medicinal materials, making ointments, preparing plasters, fixing and applying them.

[0009] As a further solution of the present invention: in the process of crushing the medicinal materials, a new airflow ultrafine powder machine TR-25 is required to mix the above medicinal materials in a ratio of 1:1:1:2:2:3:3:3:4:6, and then crush them through a 300-mesh sieve to make ultrafine powder.

[0010] As a further solution of the present invention: the specific configuration of the new airflow superfine powder machine TR-25 is as follows:

[0011] Speed: 23000RPM;

[0012] Horsepower: 2.5HP.

[0013] As a further solution of the present invention: in the ointment preparation process, the ultrafine powder prepared above needs to be taken, and appropriate amounts of vaseline and sesame oil are added and stirred evenly until a paste-like substance is formed. The specific ratio of vaseline and sesame oil is as follows:

[0014] The amount of vaseline used accounts for 10%-30% of the total powder weight;

[0015] The amount of sesame oil used accounts for 5%-20% of the total powder weight.

[0016] As a further solution of the present invention: in the preparation of the patch, the prepared paste is evenly applied on the medical dressing, and the thickness thereof is controlled to be 2 mm.

[0017] As a further solution of the present invention: during the fixing and application, the medical dressing coated with the paste substance needs to be applied to the affected area and fixed with a desensitizing tape to ensure that the paste is closely attached to the skin, and each application is for 3 to 4 hours and used 3 times a day;

[0018] Furthermore, before applying the patch, the patient should clean and dry the affected area to remove dirt and grease on the skin surface. This helps to improve the contact quality between the Chinese medicine patch and the skin and enhance the absorption efficiency of the drug. It is appropriate to use warm water for cleaning and avoid using any chemical cleaners that may cause skin irritation;

[0019] Furthermore, for patients who are using the Chinese medicine patch for the first time, it is recommended to monitor skin reactions, rashes, itching, or other discomforts after the first application, and the monitoring results should be recorded to facilitate the healthcare provider to evaluate the suitability of the patch and make necessary adjustments;

[0020] Furthermore, it is recommended to use medical dressings and desensitizing tapes that are breathable and hypoallergenic to the skin to reduce the risk of allergic reactions and improve the comfort of application. It is necessary to ensure that the selected materials comply with national or international safety standards for medical supplies.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] (1) The Chinese medicine plaster of the present invention acts directly on the affected part and is absorbed through the skin, and can quickly exert a local therapeutic effect to relieve the pain and inflammation caused by gouty arthritis. By using an ultrafine powder machine to crush the medicinal materials into ultrafine powder with a 300-mesh sieve, the surface area of ​​the drug can be increased, and the permeability and absorption efficiency of the drug can be improved. Compared with oral drugs, the external plaster can reduce the stimulation of the drug to the gastrointestinal tract and systemic side effects, and is more suitable for patients with sensitive gastrointestinal tract or other contraindications. By adjusting the ratio of vaseline and sesame oil, an ointment with suitable viscosity and good spreadability can be prepared, which is convenient for patients to use. It can be used 3 times a day, each time for 3 to 4 hours, which can ensure continuous drug effects and help stabilize and recover from the disease.

[0023] (2) In the present invention, the rhubarb and earthworm in the prescription are cold and clear, and have the effects of clearing heat and purging fire, cooling blood and detoxifying, and promoting menstruation and relieving pain. They are all the main drugs. The radix cyrtonemae is pungent and warm, and has the functions of relieving pain, dispelling wind, reducing swelling, and promoting blood circulation and detoxifying. "Simple Herbal Medicine" says: "It treats injuries from falls and pain in the tendons and bones." The radix clematis has a strong ability to move and move, and is good at removing rheumatism, promoting meridians, and relieving pain. The radix sylvestris is pungent, dispersing, warming and unblocking, and has a good nature of opening and relieving. It has a sharp medicinal effect and is a dispersing agent. It is commonly used for promoting blood circulation and reducing swelling, supporting toxins and draining pus. The three drugs are used together to remove dampness, dredge the meridians, and promote blood circulation and reduce swelling. They are all the ministerial drugs. Chuanxiong and costus root are pungent, warm and fragrant, which can not only promote blood circulation and dissipate blood stasis, but also promote qi and relieve pain, and also have the function of drying dampness; "Compendium of Materia Medica" says "Asarum... has the strongest fragrance, and its qi rises directly", and Asarum has a strong pungent and dispersing power, a thick smell, and a penetrating fragrance, which can dredge the meridians and joints inside, and penetrate the pores and orifices outside to penetrate the skin; they are all adjuvants with pungent, dispersing, warming and unblocking properties, promoting qi, dissipating blood stasis and relieving pain. Mint and borneol have the functions of cooling, pungent and dispersing, and are used as guiding drugs, and are commonly used transdermal enhancers, which can lead all drugs to penetrate directly into the subcutaneous tissue. DETAILED DESCRIPTION

[0024] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below.

[0025] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein, and those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0026] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The term "in one embodiment" that appears in different places in this specification does not necessarily refer to the same embodiment, nor does it refer to a separate or selective embodiment that is mutually exclusive with other embodiments.

[0027] Example 1

[0028] The first embodiment of the present invention provides a Chinese medicine plaster for treating gouty arthritis and a preparation method thereof, and the specific steps are as follows:

[0029] Step 1: Crush the medicinal materials: Use the new airflow ultrafine powder machine TR-25 to mix 1 part of Cynanchum chinense, 1 part of Asarum, 1 part of Borneolum, 2 parts of Aucklandia lappa, 2 parts of Pheretima, 3 parts of Chuanxiong, 3 parts of Clematidis, 3 parts of Gleditsia sinensis, 4 parts of Rhubarb, and 6 parts of Menthus in a ratio of 1:1:1:2:2:3:3:3:4:6, and crush the mixed medicinal materials through a 300-mesh sieve to make ultrafine powder;

[0030] Step 2, preparing an ointment: taking the ultrafine powder prepared above, adding appropriate amounts of vaseline and sesame oil according to the ratio of vaseline accounting for 20% of the total weight of the powder and sesame oil accounting for 10% of the total weight of the powder, and fully stirring the medicinal powder with vaseline and sesame oil until a uniform ointment is formed;

[0031] Step 3: Preparation of plaster: evenly apply the prepared paste on the medical dressing, and control the thickness of the paste to be 2 mm;

[0032] Step 4. Fix and apply: Apply the medical dressing coated with paste to the affected area of ​​gouty arthritis patients, fix it with desensitizing tape, ensure that the patch fits tightly to the skin, apply for 3 hours each time, and use 3 times a day.

[0033] Example 2

[0034] The second embodiment of the present invention changes the dosage of vaseline and sesame oil and makes adjustments in the application time, as follows:

[0035] Step 1: Crush the medicinal materials: Use the new airflow ultrafine powder machine TR-25 to mix Cynanchum cyrtonema, Asarum, Borneolum, Aucklandia lappa, Pheretima, Chuanxiong, Clematis, Gleditsia sinensis, Rhubarb, and Mentha in a ratio of 1:1:1:2:2:3:3:3:4:6, and crush through a 300-mesh sieve to make ultrafine powder;

[0036] Step 2, preparing an ointment: taking the ultrafine powder prepared above, adding appropriate amounts of vaseline and sesame oil according to the ratio of vaseline accounting for 15% of the total weight of the powder and sesame oil accounting for 7% of the total weight of the powder, and fully stirring the medicinal powder with vaseline and sesame oil until a uniform ointment is formed;

[0037] Step 3: Preparation of plaster: evenly apply the prepared paste on the medical dressing, and control the thickness of the paste to be 2 mm;

[0038] Step 4. Fix and apply: Apply the medical dressing coated with paste to the affected area of ​​gouty arthritis patients, fix it with desensitizing tape, ensure that the patch fits tightly to the skin, apply it for 4 hours each time, and use it 3 times a day.

[0039] In summary, a fixed ratio of medicinal materials and a specific ultrafine grinding technology (TR-25 ultrafine powder machine) are used in the embodiments, which helps to ensure the uniformity of the drug ingredients in the ointment and the consistency of the therapeutic effect. In the ointment making process, the ratio of vaseline and sesame oil can be adjusted as needed, which shows that the viscosity and spreadability of the ointment can be personalized according to the specific circumstances of the patient. Through different application times and frequencies, this shows that the treatment plan can be adjusted according to the patient's response and condition to achieve the best therapeutic effect. Using a desensitizing tape to fix the ointment can reduce skin irritation, reduce the risk of allergic reactions, and improve the patient's comfort.

[0040] The above is a preferred embodiment of the present application. It should be pointed out that, for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present application.

Claims

1. A Chinese medicine plaster for treating gouty arthritis and a preparation method thereof, characterized in that: The material composition is 1 part of Cynanchum chinense, 1 part of Asarum, 1 part of Borneolum, 2 parts of Aucklandia lappa, 2 parts of Pheretima, 3 parts of Chuanxiong, 3 parts of Clematidis, 3 parts of Gleditsia sinensis, 4 parts of Rhubarb, 6 parts of Mint, appropriate amount of Vaseline, appropriate amount of sesame oil, medical dressing and desensitizing tape.

2. A Chinese medicine plaster for treating gouty arthritis and a preparation method thereof according to claim 1, characterized in that: The preparation process includes medicinal material crushing, ointment making, plaster preparation, fixing and applying.

3. A Chinese medicine plaster for treating gouty arthritis and a preparation method thereof according to claim 2, characterized in that: In the process of crushing the medicinal materials, a new airflow ultrafine powder machine TR-25 is required to mix the above medicinal materials in a ratio of 1:1:1:2:2:3:3:3:4:6, and then crush them through a 300-mesh sieve to make ultrafine powder.

4. A Chinese medicine plaster for treating gouty arthritis and a preparation method thereof according to claim 3, characterized in that: The specific configuration of the new airflow superfine powder machine TR-25 is as follows: Speed: 23000RPM; Horsepower: 2.5HP.

5. A Chinese medicine plaster for treating gouty arthritis and a preparation method thereof according to claim 2, characterized in that: In the ointment preparation process, the prepared ultrafine powder is taken, and appropriate amounts of vaseline and sesame oil are added and stirred evenly until a paste is formed. The specific ratio of vaseline and sesame oil is as follows: The amount of vaseline used accounts for 10%-30% of the total powder weight; The amount of sesame oil used accounts for 5%-20% of the total powder weight.

6. A Chinese medicine plaster for treating gouty arthritis and a preparation method thereof according to claim 2, characterized in that: In the preparation of the patch, the prepared paste is evenly applied on the medical dressing, and the thickness thereof is controlled to be 2 mm.

7. A Chinese medicine plaster for treating gouty arthritis and a preparation method thereof according to claim 2, characterized in that: During the fixing and application, the medical dressing coated with the paste substance needs to be applied to the affected area and fixed with a desensitizing tape to ensure that the paste fits the skin tightly. The application should be for 3 to 4 hours each time and used 3 times a day.