Antibacterial pharmaceutical composition and application thereof in pets

Abstract

The invention belongs to the technical field of veterinary drugs, and relates to an antibacterial pharmaceutical composition and application thereof in pets. The antibacterial pharmaceutical composition is prepared from the following raw materials in parts by weight: 20-30 parts of a purslane extract, 20-30 parts of a cacumen biotae extract, 10-20 parts of a gallnut extract, 13-18 parts of a dandelion extract and 5-10 parts of a schisandra chinensis extract. In-vitro tests show that the antibacterial pharmaceutical composition disclosed by the invention has a remarkable inhibition effect on staphylococcus chromogenes, staphylococcus intermedius and pseudomonas aeruginosa. Animal tests show that the antibacterial pharmaceutical composition has a remarkable treatment effect on dog demodex dermatosis.

Description

Technical Field

[0001] The invention belongs to the technical field of veterinary drugs, and in particular relates to an antibacterial drug composition and application thereof in pets. Background Art

[0002] Canine demodectic mange is common in puppies and occasionally in adult dogs. Canine demodectic mange is mostly parasitic on parts with less hair, such as eyes, ears, nose, lips and joints of limbs. Erythema, papules and dandruff can be seen on the affected areas. Severe cases can develop into systemic infection. If treatment is not timely or care is inadequate, it can cause bacteremia, sepsis, and eventually autointoxication and death.

[0003] To date, there are a variety of treatment options for canine demodicosis, with varying results, such as oral ivermectin, amitraz bathing, external drops of Ivermectin (imidacloprid + moxidectin), oral Nikosin (Afolan), and oral One Tablet of Flurella.

[0004] Bacteria are the culprits of many infectious diseases in pets. Many Chinese medicines have antibacterial effects. Chinese medicines have the advantages of being natural, non-resistant, non-dependent, and low in toxicity and side effects, and suitable for long-term use. It is of great significance to study the treatment of skin diseases in dogs and cats with Chinese medicine. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention provides an antibacterial drug composition, which has a significant inhibitory effect on Staphylococcus aureus, Staphylococcus intermedius and Pseudomonas aeruginosa. Animal experiments have found that the antibacterial drug composition of the present invention has a significant therapeutic effect on canine demodex skin disease.

[0006] To achieve the above purpose, the technical solution adopted by the present invention is: The invention provides an antibacterial drug composition, which is prepared from the following raw materials in parts by weight: 20-30 parts of purslane extract, 20-30 parts of orientalis leaf extract, 10-20 parts of gallnut extract, 13-18 parts of dandelion extract and 5-10 parts of schisandra chinensis extract.

[0007] Furthermore, the antibacterial drug composition is made of the following raw materials in parts by weight: 25 parts of purslane extract, 25 parts of Platycladus orientalis leaf extract, 15 parts of Galla chinensis extract, 15 parts of dandelion extract, and 8 parts of Schisandra chinensis extract.

[0008] Furthermore, the Portulaca oleracea extract and Platycladus orientalis leaf extract are extracts prepared by an alcohol extraction process.

[0009] Furthermore, the Galla chinensis extract, the Taraxacum officinale extract and the Schisandra chinensis extract are extracts prepared by a water extraction process.

[0010] A method for preparing an antibacterial drug composition comprises the following steps: (1) accurately weighing purslane and Platycladus orientalis leaves, adding 5-8 times by weight of 60% ethanol solution respectively, soaking for 1-3 hours, keeping slightly boiling for 70-100 minutes, and refluxing extraction twice; filtering with gauze, combining the two filtrates, recovering ethanol from the alcohol extract, concentrating, and spray drying to obtain extract powder corresponding to the materials; (2) drying gallnut, dandelion, and schisandra chinensis, adding 5-8 times by weight of purified water respectively, soaking for 1-3 hours, boiling over high heat and then simmering over low heat for 20-40 minutes, filtering with gauze, boiling again in the same way, filtering, combining the two liquid medicines, concentrating, and spray drying to obtain extract powder corresponding to the materials; (3) accurately weighing the corresponding materials according to the formula, and fully mixing them for 10-20 minutes using a three-dimensional motion mixer; (4) packaging the mixture obtained in step (3) using an automatic packaging machine to obtain the product.

[0011] Furthermore, the preparation method of the antibacterial drug composition comprises the following steps: (1) accurately weighing purslane and Platycladus orientalis leaves, adding 6 times the weight of 60% ethanol solution respectively, soaking for 2 hours, keeping slightly boiling for 80 minutes, and reflux extraction twice; filtering with gauze, combining the two filtrates, recovering ethanol from the alcohol extract, concentrating, and spray drying to obtain the extract powder corresponding to the material; (2) drying gallnut, dandelion, and schisandra chinensis, adding 8 times the weight of purified water respectively, soaking for 2 hours, boiling over high heat and then simmering over low heat for 30 minutes, filtering with gauze, boiling again in the same way, filtering, combining the two liquid medicines, concentrating, and spray drying to obtain the extract powder corresponding to the material; (3) accurately weighing the corresponding materials according to the formula, and fully mixing them for 15 minutes using a three-dimensional motion mixer; (4) packaging the mixture obtained in step (3) using an automatic packaging machine to obtain the product.

[0012] Furthermore, the antibacterial drug composition is prepared as one of granules, tablets, capsules, ointments, oral liquids, emulsions, and suspensions.

[0013] Furthermore, the antibacterial drug composition is prepared as granules.

[0014] The present invention provides use of the antibacterial drug composition in preparing antibacterial drugs for treating pets.

[0015] Furthermore, the pet is a mammal.

[0016] Furthermore, the pet is a cat or a dog.

[0017] Compared with the prior art, the present invention has the following beneficial effects: The antibacterial composition of the present invention is prepared by extracting natural traditional Chinese medicine, and through scientific formula and proportion, the synergistic effect between various components significantly enhances the antibacterial effect and inhibits the growth of bacteria.

[0018] In vitro tests show that the antibacterial drug composition of the present invention has a significant inhibitory effect on Staphylococcus aureus, Staphylococcus intermedius and Pseudomonas aeruginosa. Animal tests show that the antibacterial drug composition of the present invention has a significant therapeutic effect on canine demodex skin disease. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 To compare the efficacy of each group. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention.

[0021] Example 1 The invention provides an antibacterial drug composition, which is prepared from the following raw materials in parts by weight: 25 parts of purslane extract, 25 parts of oriental arborvitae leaf extract, 15 parts of gallnut extract, 15 parts of dandelion extract and 8 parts of schisandra chinensis extract.

[0022] The preparation method of the antibacterial drug composition comprises the following steps: (1) accurately weighing purslane and Platycladus orientalis leaves, adding 6 times the weight of 60% ethanol solution respectively, soaking for 2 hours, keeping slightly boiling for 80 minutes, and reflux extraction twice; filtering with gauze, combining the two filtrates, recovering ethanol from the alcohol extract, concentrating, and spray drying to obtain the extract powder corresponding to the material; (2) drying gallnut, dandelion, and schisandra chinensis, adding 8 times the weight of purified water respectively, soaking for 2 hours, boiling over high heat and then simmering over low heat for 30 minutes, filtering with gauze, boiling again in the same way, filtering, combining the two liquid medicines, concentrating, and spray drying to obtain the extract powder corresponding to the material; (3) accurately weighing the corresponding materials according to the formula, and fully mixing them for 15 minutes using a three-dimensional motion mixer; (4) packaging the mixture obtained in step (3) using an automatic packaging machine to obtain the product.

[0023] Example 2 An antibacterial drug composition is prepared from the following raw materials in parts by weight: 20 parts of purslane extract, 30 parts of oriental arborvitae leaf extract, 20 parts of gallnut extract, 18 parts of dandelion extract and 5 parts of schisandra chinensis extract.

[0024] A method for preparing an antibacterial drug composition comprises the following steps: (1) accurately weighing purslane and Platycladus orientalis leaves, adding 5 times by weight of 60% ethanol solution respectively, soaking for 2 hours, keeping slightly boiling for 70 minutes, and refluxing extraction twice; filtering with gauze, combining the two filtrates, recovering ethanol from the alcohol extract, concentrating, and spray drying to obtain extract powder corresponding to the materials; (2) drying gallnut, dandelion, and schisandra chinensis, adding 8 times by weight of purified water respectively, soaking for 1 hour, boiling over high heat and then simmering over low heat for 20 minutes, filtering with gauze, boiling again in the same way, filtering, combining the two liquid medicines, concentrating, and spray drying to obtain extract powder corresponding to the materials; (3) accurately weighing the corresponding materials according to the formula, and fully mixing them for 10 minutes using a three-dimensional motion mixer; (4) packaging the mixture obtained in step (3) using an automatic packaging machine to obtain the product.

[0025] Example 3 An antibacterial drug composition is prepared from the following raw materials in parts by weight: 30 parts of purslane extract, 20 parts of oriental arborvitae leaf extract, 10 parts of gallnut extract, 13 parts of dandelion extract and 10 parts of schisandra chinensis extract.

[0026] A method for preparing an antibacterial drug composition comprises the following steps: (1) accurately weighing purslane and Platycladus orientalis leaves, adding 6 times by weight of 60% ethanol solution respectively, soaking for 2 hours, keeping slightly boiling for 90 minutes, and reflux extraction twice; filtering with gauze, combining the two filtrates, recovering ethanol from the alcohol extract, concentrating, and spray drying to obtain extract powder corresponding to the materials; (2) drying gallnut, dandelion, and schisandra chinensis, adding 7 times by weight of purified water respectively, soaking for 3 hours, boiling over high heat and then simmering over low heat for 25 minutes, filtering with gauze, boiling again in the same way, filtering, combining the two liquid medicines, concentrating, and spray drying to obtain extract powder corresponding to the materials; (3) accurately weighing the corresponding materials according to the formula, and fully mixing them for 20 minutes using a three-dimensional motion mixer; (4) packaging the mixture obtained in step (3) using an automatic packaging machine to obtain the product.

[0027] Example 4 An antibacterial drug composition is prepared from the following raw materials in parts by weight: 25 parts of purslane extract, 20 parts of oriental arborvitae leaf extract, 20 parts of gallnut extract, 13 parts of dandelion extract and 10 parts of schisandra chinensis extract.

[0028] A method for preparing an antibacterial drug composition comprises the following steps: (1) accurately weighing purslane and orientalis leaves, adding 8 times by weight of 60% ethanol solution respectively, soaking for 1 hour, keeping slightly boiling for 70 minutes, and refluxing extraction twice; filtering with gauze, combining the two filtrates, recovering ethanol from the alcohol extract, concentrating, and spray drying to obtain extract powder corresponding to the materials; (2) drying gallnut, dandelion, and schisandra chinensis, adding 5 times by weight of purified water respectively, soaking for 3 hours, boiling over high heat and then simmering over low heat for 40 minutes, filtering with gauze, boiling again in the same way, filtering, combining the two liquid medicines, concentrating, and spray drying to obtain extract powder corresponding to the materials; (3) accurately weighing the corresponding materials according to the formula, and fully mixing them for 20 minutes using a three-dimensional motion mixer; (4) packaging the mixture obtained in step (3) using an automatic packaging machine to obtain the product.

[0029] Example 5 An antibacterial drug composition is prepared from the following raw materials in parts by weight: 30 parts of purslane extract, 25 parts of oriental arborvitae leaf extract, 10 parts of gallnut extract, 18 parts of dandelion extract and 5 parts of schisandra chinensis extract.

[0030] A method for preparing an antibacterial drug composition comprises the following steps: (1) accurately weighing purslane and orientalis leaves, adding 8 times by weight of 60% ethanol solution respectively, soaking for 2 hours, keeping slightly boiling for 100 minutes, and reflux extraction twice; filtering with gauze, combining the two filtrates, recovering ethanol from the alcohol extract, concentrating, and spray drying to obtain extract powder corresponding to the materials; (2) drying gallnut, dandelion, and schisandra chinensis, adding 6 times by weight of purified water respectively, soaking for 3 hours, boiling over high heat and then simmering over low heat for 20 minutes, filtering with gauze, boiling again in the same way, filtering, combining the two liquid medicines, concentrating, and spray drying to obtain extract powder corresponding to the materials; (3) accurately weighing the corresponding materials according to the formula, and fully mixing them for 15 minutes using a three-dimensional motion mixer; (4) packaging the mixture obtained in step (3) using an automatic packaging machine to obtain the product.

[0031] Example 6 An antibacterial drug composition is prepared from the following raw materials in parts by weight: 30 parts of purslane extract, 20 parts of oriental arborvitae leaf extract, 15 parts of gallnut extract, 15 parts of dandelion extract and 10 parts of schisandra chinensis extract.

[0032] A method for preparing an antibacterial drug composition comprises the following steps: (1) accurately weighing purslane and Platycladus orientalis leaves, adding 7 times by weight of 60% ethanol solution respectively, soaking for 1 hour, keeping slightly boiling for 80 minutes, and reflux extraction twice; filtering with gauze, combining the two filtrates, recovering ethanol from the alcohol extract, concentrating, and spray drying to obtain extract powder corresponding to the materials; (2) drying gallnut, dandelion, and schisandra chinensis, adding 5 times by weight of purified water respectively, soaking for 2 hours, boiling over high heat and then simmering over low heat for 30 minutes, filtering with gauze, boiling again in the same way, filtering, combining the two liquid medicines, concentrating, and spray drying to obtain extract powder corresponding to the materials; (3) accurately weighing the corresponding materials according to the formula, and fully mixing them for 10 minutes using a three-dimensional motion mixer; (4) packaging the mixture obtained in step (3) using an automatic packaging machine to obtain the product.

[0033] Comparative Example 1 The invention provides an antibacterial drug composition, which is prepared from the following raw materials in parts by weight: 25 parts of purslane extract, 25 parts of oriental arborvitae leaf extract, 15 parts of gallnut extract, 15 parts of dandelion extract and 8 parts of schisandra chinensis extract.

[0034] The preparation method of the antibacterial drug composition comprises the following steps: (1) drying purslane, arborvitae leaves, gallnut, dandelion and schisandra chinensis, adding 8 times the weight of purified water to each of them and soaking them for 2 hours, boiling them over high heat and then simmering them over low heat for 30 minutes, filtering them through gauze, boiling them again in the same way, filtering them, combining the two drug solutions, concentrating and spray drying them to obtain extract powder corresponding to the materials; (2) accurately weighing the corresponding materials according to the formula, and fully mixing them for 15 minutes using a three-dimensional motion mixer; (3) packaging the mixture obtained in step (2) using an automatic packaging machine to obtain the product.

[0035] Comparative Example 2 The invention provides an antibacterial drug composition, which is prepared from the following raw materials in parts by weight: 25 parts of purslane extract, 25 parts of oriental arborvitae leaf extract, 15 parts of gallnut extract, 15 parts of dandelion extract and 8 parts of schisandra chinensis extract.

[0036] The preparation method of the antibacterial drug composition comprises the following steps: (1) accurately weighing purslane, Platycladus orientalis leaves, Galla chinensis, dandelion and Schisandra chinensis, adding 6 times the weight of 60% ethanol solution respectively, soaking for 2 hours, keeping slightly boiling for 80 minutes, and reflux extraction twice; filtering with gauze, combining the two filtrates, recovering ethanol from the alcohol extract, concentrating and spray drying to obtain the extract powder corresponding to the material; (2) accurately weighing the corresponding materials according to the formula, and fully mixing them for 15 minutes using a three-dimensional motion mixer; (3) packaging the mixture obtained in step (2) with an automatic packaging machine to obtain the product.

[0037] Comparative Example 3 The invention provides an antibacterial drug composition, which is prepared from the following raw materials in parts by weight: 25 parts of purslane extract, 25 parts of coptis extract, 15 parts of gallnut extract, 15 parts of sophora flavescens extract and 8 parts of schisandra chinensis extract.

[0038] The preparation method of the antibacterial drug composition comprises the following steps: (1) accurately weighing purslane and coptis root, adding 6 times the weight of 60% ethanol solution respectively, soaking for 2 hours, keeping slightly boiling for 80 minutes, and reflux extraction twice; filtering with gauze, combining the two filtrates, recovering ethanol from the alcohol extract, concentrating, and spray drying to obtain the extract powder corresponding to the material; (2) drying gallnut, sophora flavescens, and schisandra chinensis, adding 8 times the weight of purified water respectively, soaking for 2 hours, boiling over high heat and then simmering over low heat for 30 minutes, filtering with gauze, boiling again in the same way, filtering, combining the two drug solutions, concentrating, and spray drying to obtain the extract powder corresponding to the material; (3) accurately weighing the corresponding materials according to the formula, and fully mixing them for 15 minutes using a three-dimensional motion mixer; (4) packaging the mixture obtained in step (3) using an automatic packaging machine to obtain the product.

[0039] Efficacy Example 1 Study on the antibacterial effect of the antibacterial drug composition of the present invention in vitro 1. Experimental Methods The experimental drugs are as follows: Example 1 Drug: Combine the filtrate obtained by alcohol extraction of Portulaca oleracea and Platycladus orientalis leaves in step (1) of Example 1 with the filtrate obtained by water extraction of Galla chinensis, Taraxacum officinale and Schisandra chinensis in step (2).

[0040] Example 2 Drug: Combine the filtrate obtained by alcohol extraction of Portulaca oleracea and Platycladus orientalis leaves in step (1) of Example 2 with the filtrate obtained by water extraction of Galla chinensis, Taraxacum officinale and Schisandra chinensis in step (2).

[0041] The drug of Example 3: the filtrate obtained by alcohol extraction of Portulaca oleracea and Platycladus orientalis leaves in step (1) of Example 3 and the filtrate obtained by water extraction of Galla chinensis, Taraxacum officinale and Schisandra chinensis in step (2) are combined.

[0042] Comparative Example 1: the drug; the filtrate obtained by water extraction of purslane, Platycladus orientalis leaves, Galla chinensis, Taraxacum officinale and Schisandra chinensis in step (1) of Comparative Example 1.

[0043] Comparative Example 2: medicine; filtrate obtained by alcohol extraction of purslane, Platycladus orientalis leaves, Galla chinensis, dandelion and Schisandra chinensis in step (1) of Comparative Example 2.

[0044] Comparative Example 3 Drug: Combine the filtrate obtained by alcohol extraction of Portulaca oleracea and Coptis chinensis in step (1) of Comparative Example 3 and the filtrate obtained by water extraction of Galla chinensis, Sophora flavescens and Schisandra chinensis in step (2).

[0045] Preparation of drug sensitivity paper: Take a sterilized filter paper with a diameter of 0.6 cm and soak it in each of the above-mentioned drug solutions for 40 minutes, then take it out for use. The drug sensitivity paper method and determination method shall refer to the "Guide to Veterinary Microbiology Experiments".

[0046] Preparation of bacterial solution: First, prepare blood agar medium according to the instructions for making it, inoculate pathogens (Staphylococcus aureus, Staphylococcus intermedius, and Pseudomonas aeruginosa) on it, and culture it at 37°C. Use a blood cell counting plate to adjust the concentration of the bacterial solution to 5-6×10 4 pcs / mL, for future use.

[0047] Inoculation: Use a micropipette to absorb 5 μL of the prepared bacterial solution and evenly spread it on the surface of nutrient agar. Place drug-sensitive paper strips on the plate coated with bacteria, four strips for each drug, and then place the plate in a 37°C incubator for 24 hours. After that, measure the size of the inhibition zone and take the average value. Use the size of the inhibition zone to determine the antibacterial effect.

[0048] 2. Experimental results The drugs in Example 1, Example 2 and Example 3 all have inhibitory effects on various pathogenic bacteria, and the inhibitory effects of the drug in Example 1 on the three pathogenic bacteria are higher than those of the comparative example drug. The results are shown in Table 1.

[0049] Table 1 In vitro antibacterial results of each group of drugs The antibacterial drug composition of the invention has a significant inhibitory effect on chromogenic Staphylococcus aureus, Staphylococcus intermedius and Pseudomonas aeruginosa.

[0050] Efficacy Example 2 Clinical efficacy test of the antibacterial drug composition of the present invention on canine demodectic mange 1. Experimental Methods 1. Diagnosis A total of 20 dogs were diagnosed with simple localized skin infection (mainly on the neck, back, and chest) of demodicosis through microscopic examination in the outpatient clinic.

[0051] 2. Grouping and Dosing Control group: oral ivermectin, the dosage was increased successively, 0.1 mg / kg on the first day, 0.2 mg / kg on the second day, 0.3 mg / kg on the third day, and maintained at 0.4 mg / kg on the fourth day for 2 weeks until the microscopic examination result was negative, and then consolidated medication for 10 days.

[0052] Observation group: took the decoction prepared in Example 1 once a day for 28 days.

[0053] 3. Efficacy evaluation The efficacy is divided into three levels: cured, markedly effective, and ineffective. The evaluation criteria are as follows: 1) Cured: skin symptoms completely subside or only a small amount of pigmentation remains, hair regenerates and becomes shiny, the itching completely disappears, and two consecutive Demodex microscopic examinations are negative; 2) Markedly effective: skin inflammatory lesions subside by >20%, the itching is significantly relieved, some hair begins to grow, and positive Demodex microscopic examinations are rare; 3) Ineffective: skin lesions subside very little, <20% or continue to worsen, the itching has not significantly subsided or is severe, hair loss is severe, and Demodex microscopic examinations are positive.

[0054] Cure rate (%) Number of cured cases / total number of treated cases 100%; Significant efficacy (%) = number of cases with significant efficacy / total number of cases treated 100%; Total effective rate (%) = (number of cured cases + number of markedly effective cases) / total number of treated cases 100%.

[0055] 4. Statistical methods SPSS 22.0 software was used for data processing, and the obtained data were expressed as mean Standard Deviation The data of each group were subjected to normal distribution test and variance homogeneity test, and the inter-group comparison was performed with one-way analysis of variance, with P < 0.05 as the difference being statistically significant.

[0056] 2. Results Comparison of efficacy between the two groups The total effective rate of the observation group was better than that of the control group. The results are shown in Table 2 and Figure 1 .

[0057] Table 2 Comparison of efficacy between the two groups The antibacterial drug composition of the present invention has a significant therapeutic effect on canine demodex skin disease.

[0058] The above embodiments are merely examples for clear explanation and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description, and the obvious changes or modifications derived therefrom are still within the scope of protection of the present invention.

Claims

1. An antibacterial drug composition, characterized in that: The antibacterial drug composition is prepared from the following raw materials in parts by weight: 20-30 parts of purslane extract, 20-30 parts of orientalis leaf extract, 10-20 parts of gallnut extract, 13-18 parts of dandelion extract and 5-10 parts of schisandra chinensis extract.

2. The antibacterial drug composition according to claim 1, characterized in that: The antibacterial drug composition is prepared from the following raw materials in parts by weight: 25 parts of purslane extract, 25 parts of orientalis leaf extract, 15 parts of gallnut extract, 15 parts of dandelion extract and 8 parts of schisandra chinensis extract.

3. The antibacterial drug composition according to claim 1, characterized in that: The purslane extract and the Platycladus orientalis leaf extract are extracts prepared by an alcohol extraction process.

4. The antibacterial drug composition according to claim 1, characterized in that: The gallnut extract, dandelion extract and schisandra chinensis extract are extracts prepared by water extraction process.

5. A method for preparing an antibacterial drug composition, characterized in that: The following steps are involved: (1) Accurately weigh purslane and Platycladus orientalis leaves, add 5-8 times the weight of 60% ethanol solution respectively, soak for 1-3 hours, keep slightly boiling for 70-100 minutes, and reflux extraction twice; filter with gauze, combine the two filtrates, recover ethanol from the alcohol extract, concentrate, and spray dry to obtain the extract powder corresponding to the material; (2) Dry the gallnut, dandelion, and Schisandra chinensis, add 5-8 times the weight of purified water respectively, soak for 1-3 hours, boil over high heat and then simmer over low heat for 20-40 minutes, filter with gauze, boil again in the same way, filter, combine the two liquid medicines, concentrate, and spray dry to obtain the extract powder corresponding to the material; (3) Accurately weigh the corresponding materials according to the formula, and fully mix them for 10-20 minutes using a three-dimensional motion mixer; (4) The mixture obtained in step (3) is packaged by an automatic packaging machine to obtain the product.

6. The method for preparing the antibacterial drug composition according to claim 5, characterized in that: The following steps are involved: (1) Accurately weigh purslane and Platycladus orientalis leaves, add 6 times the weight of 60% ethanol solution respectively, soak for 2 hours, keep slightly boiling for 80 minutes, and reflux extraction twice; filter with gauze, combine the two filtrates, recover ethanol from the alcohol extract, concentrate, and spray dry to obtain the extract powder corresponding to the material; (2) Dry the gallnut, dandelion, and Schisandra chinensis, add 8 times the weight of purified water respectively, soak for 2 hours, boil over high heat and then simmer for 30 minutes, filter with gauze, boil again in the same way, filter, combine the two liquids, concentrate, and spray dry to obtain the extract powder corresponding to the material; (3) Accurately weigh the corresponding materials according to the formula, and fully mix them for 15 minutes using a three-dimensional motion mixer; (4) The mixture obtained in step (3) is packaged by an automatic packaging machine to obtain the product.

7. The method for preparing the antibacterial drug composition according to claim 5, characterized in that: The antibacterial drug composition is prepared in the form of granules, tablets, capsules, ointments, oral liquids, emulsions, and suspensions.

8. The method for preparing the antibacterial drug composition according to claim 7, characterized in that: The antibacterial drug composition is prepared in the form of granules.

9. Use of the antibacterial drug composition according to claim 1 in the preparation of antibacterial drugs for treating pets.

10. The use of the antibacterial pharmaceutical composition according to claim 9, characterized in that: The pet is a cat or a dog.

Images