Voglibose tablet for preventing gastric mucosal injury and preparation process thereof

Abstract

The invention discloses a voglibose tablet for preventing gastric mucosal injury and a preparation process of the voglibose tablet. The voglibose tablet comprises 1-5 parts of codonopsis pilosula, 1-5 parts of cinnamon, 1-5 parts of liquorice, 1-5 parts of caudate sweetleaf leaves, 1-5 parts of elecampane, 1-5 parts of fennel, 1-5 parts of fried caudate sweetleaf leaves, 1-5 parts of sabina chinensis paste, 1-5 parts of liquorice, 1-5 parts of ginger, 1-5 parts of Chinese dates, 1-5 parts of Chinese yam, 1-5 parts of smoked plums, 1-5 parts of hawthorn, 1-5 parts of radix glehniae and 1-5 parts of pericarpium citri reticulatae. The voglibose tablet prepared by the method disclosed by the invention is good in sugar content uniformity and high in dissolution rate, the medicine utilization rate is improved, and the hypoglycemic effect of the voglibose can be better exerted; the Chinese dates, the Chinese yams, the smoked plums and the haws are added into the voglibose tablet, so that the voglibose tablet is slightly fragrant in smell and slightly sweet in taste, the taste experience degree of a user is improved, the gastric mucosa of the user is protected, and the voglibose tablet is high in practicability.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a voglibose tablet for preventing gastric mucosal damage and a preparation process thereof. Background Art

[0002] Voglibose tablets are a commonly used hypoglycemic drug, mainly used to treat type 2 diabetes. Its efficacy and effects include lowering blood sugar, improving insulin sensitivity, reducing weight, reducing the risk of complications and improving the quality of life. The specific analysis is as follows: Voglibose tablets inhibit the activity of α-glucosidase in the intestines and delay the absorption of carbohydrates, thereby reducing postprandial blood sugar levels. This is of great significance for controlling blood sugar fluctuations in patients with type 2 diabetes. Voglibose tablets can improve insulin sensitivity, allowing insulin to work more effectively and lower blood sugar. This has a positive effect on reducing insulin resistance and improving the metabolic status of diabetic patients. Voglibose tablets help lose weight by lowering postprandial blood sugar levels and reducing carbohydrate intake. For diabetic patients, this will help improve metabolic disorders and reduce the risk of complications. Voglibose tablets can lower blood sugar, improve insulin sensitivity, reduce weight and other aspects, thereby reducing the risk of cardiovascular, renal and other complications in diabetic patients. Voglibose tablets can effectively control blood sugar, alleviate symptoms of diabetic patients and improve the quality of life. At the same time, the drug has fewer side effects and is well tolerated by patients, which is conducive to long-term use. As a hypoglycemic drug, voglibose tablets have significant advantages in the treatment of type 2 diabetes. Patients still need to pay attention to lifestyle adjustments such as diet control and exercise during use to achieve better treatment effects. At the same time, patients should monitor their blood sugar regularly and adjust the dosage of medication as prescribed by the doctor to ensure that blood sugar control is met.

[0003] However, traditional voglibose tablets have the following disadvantages:

[0004] Traditional voglibose tablets dissolve slowly, which makes the voglibose tablets take a long time to take effect, affecting the hypoglycemic effect of voglibose tablets to varying degrees. Summary of the invention

[0005] The object of the present invention is to provide a voglibose tablet for preventing gastric mucosal damage and a preparation process thereof, so as to solve the problem that the traditional voglibose tablets proposed in the above background technology dissolve slowly, resulting in a long onset time of the voglibose tablets, which affects the hypoglycemic effect of the voglibose tablets to varying degrees.

[0006] To achieve the above-mentioned object, the present invention provides the following technical scheme: a voglibose tablet for preventing gastric mucosal damage, comprising a voglibose tablet, wherein the voglibose tablet comprises 1-5 parts of codonopsis pilosula, 1-5 parts of cinnamon bark, 1-5 parts of licorice, 1-5 parts of alum leaves, 1-5 parts of elecampane, 1-5 parts of fennel, 1-5 parts of stir-fried alum leaves, 1-5 parts of juniper paste, 1-5 parts of licorice, 1-5 parts of ginger, 1-5 parts of jujube, 1-5 parts of yam, 1-5 parts of ebony, 1-5 parts of hawthorn, 1-5 parts of northern adenophora, 1-5 parts of tangerine peel, 20-30 parts of corn starch, 30-50 parts of voglibose, 10-20 parts of lactose and 10-20 parts of hydroxypropyl cellulose.

[0007] As a preferred technical solution of the present invention, the voglibose tablets include 1 part of codonopsis pilosula, 1 part of cinnamon, 1 part of licorice, 1 part of alum leaf, 1 part of elecampane, 1 part of fennel, 1 part of stir-fried alum leaf, 1 part of juniper paste, 1 part of licorice, 1 part of ginger, 1 part of jujube, 1 part of yam, 1 part of black plum, 1 part of hawthorn, 3 parts of northern adenophora, 3 parts of tangerine peel, 20 parts of corn starch, 30 parts of voglibose, 20 parts of lactose and 10 parts of hydroxypropyl cellulose.

[0008] As a preferred technical solution of the present invention, the voglibose tablets include 1 part of codonopsis pilosula, 1 part of cinnamon, 1 part of licorice, 1 part of alum leaf, 1 part of elecampane, 1 part of fennel, 1 part of stir-fried alum leaf, 1 part of juniper paste, 1 part of licorice, 1 part of ginger, 1 part of jujube, 1 part of yam, 3 parts of ebony, 3 parts of hawthorn, 1 part of northern adenophora, 1 part of tangerine peel, 20 parts of corn starch, 30 parts of voglibose, 10 parts of lactose and 20 parts of hydroxypropyl cellulose.

[0009] As a preferred technical solution of the present invention, the voglibose tablets include 1 part of codonopsis pilosula, 1 part of cinnamon, 1 part of licorice, 1 part of alum leaf, 1 part of elecampane, 1 part of fennel, 1 part of stir-fried alum leaf, 1 part of juniper paste, 1 part of licorice, 1 part of ginger, 3 parts of jujube, 3 parts of yam, 1 part of ebony, 1 part of hawthorn, 1 part of northern adenophora, 1 part of tangerine peel, 30 parts of corn starch, 30 parts of voglibose, 10 parts of lactose and 10 parts of hydroxypropyl cellulose.

[0010] As a preferred technical solution of the present invention, the voglibose tablets include 1 part of codonopsis pilosula, 1 part of cinnamon, 1 part of licorice, 1 part of alum leaf, 1 part of elecampane, 1 part of fennel, 1 part of stir-fried alum leaf, 1 part of juniper paste, 2 parts of licorice, 2 parts of ginger, 2 parts of jujube, 2 parts of yam, 1 part of ebony, 1 part of hawthorn, 1 part of northern adenophora, 1 part of tangerine peel, 20 parts of corn starch, 35 parts of voglibose, 10 parts of lactose and 15 parts of hydroxypropyl cellulose.

[0011] The present invention provides a preparation process of a voglibose tablet for preventing gastric mucosal damage, comprising the following steps:

[0012] Step 1: Slurry preparation: slowly add 10-20 parts of hydroxypropyl cellulose into 60-80°C purified water to prepare a binder solution, start stirring, and after the binder is swollen, dissolved and defoamed, add 30-50 parts of the raw material voglibose, dissolve it, and set aside;

[0013] Step 2, raw material preparation: weigh 1-5 parts of codonopsis pilosula, 1-5 parts of cinnamon, 1-5 parts of licorice, 1-5 parts of alum leaves, 1-5 parts of elecampane, 1-5 parts of fennel, 1-5 parts of stir-fried alum leaves, 1-5 parts of juniper paste, 1-5 parts of licorice, 1-5 parts of ginger, 1-5 parts of jujube, 1-5 parts of yam, 1-5 parts of ebony, 1-5 parts of hawthorn, 1-5 parts of northern adenophora, 1-5 parts of tangerine peel, 20-30 parts of corn starch and 10-20 parts of lactose, and transfer them to a granulator for sieving;

[0014] Step 3: Product granulation: the raw materials prepared in step 2 are transferred into a fluidized bed granulator for premixing, and dry granules are obtained by discharging the materials;

[0015] Step 4: tabletting: the dry granules prepared in step 3 are put into a tablet press to form a finished product.

[0016] As a preferred technical solution of the present invention, the screening in step 2 is specifically performed with a mesh size of 0.8 mm and a controlled rotation speed of 750-1000 rpm.

[0017] As a preferred technical solution of the present invention, the premixing in step three is specifically to open the air volume 20m / h, the fan frequency 40Hz, the inlet air temperature 60-80℃, and when the material temperature rises to 28-43, open the air volume 20-80m / h, the fan frequency 40Hz, and the inlet air temperature 60-80℃.

[0018] As a preferred technical solution of the present invention, the dry particles obtained in step three are continuously sprayed with the slurry prepared in step one and dried at an inlet air temperature of 70° C. The particles are discharged when the moisture content is controlled to be 1%-3%.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] 1. The voglibose tablets prepared by this method have good uniformity of sugar content and high solubility, which improves the drug utilization rate and can better exert the blood sugar lowering effect of voglibose;

[0021] 2. Adding jujube, yam, black plum and hawthorn to the Voglib sugar tablets makes the tablets slightly fragrant and slightly sweet, which increases the user's taste experience and protects the user's gastric mucosa, making it highly practical. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1It is a flow chart of the present invention. DETAILED DESCRIPTION

[0023] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0024] Embodiment 1:

[0025] See also Figure 1 The present invention provides a voglibose tablet for preventing gastric mucosal damage, comprising a voglibose tablet, wherein the voglibose tablet comprises 1-5 parts of codonopsis pilosula, 1-5 parts of cinnamon bark, 1-5 parts of liquorice, 1-5 parts of alum leaves, 1-5 parts of elecampane, 1-5 parts of fennel, 1-5 parts of stir-fried alum leaves, 1-5 parts of juniper paste, 1-5 parts of liquorice, 1-5 parts of ginger, 1-5 parts of jujube, 1-5 parts of yam, 1-5 parts of black plum, 1-5 parts of hawthorn, 1-5 parts of northern adenophora, 1-5 parts of tangerine peel, 20-30 parts of corn starch, 30-50 parts of voglibose, 10-20 parts of lactose and 10-20 parts of hydroxypropyl cellulose.

[0026] The present invention provides a preparation process of a voglibose tablet for preventing gastric mucosal damage, comprising the following steps:

[0027] Step 1: Slurry preparation: slowly add 10-20 parts of hydroxypropyl cellulose into 60-80°C purified water to prepare a binder solution, start stirring, and after the binder is swollen, dissolved and defoamed, add 30-50 parts of the raw material voglibose, dissolve it, and set aside;

[0028] Step 2, raw material preparation: weigh 1-5 parts of codonopsis pilosula, 1-5 parts of cinnamon, 1-5 parts of licorice, 1-5 parts of alum leaves, 1-5 parts of elecampane, 1-5 parts of fennel, 1-5 parts of stir-fried alum leaves, 1-5 parts of juniper paste, 1-5 parts of licorice, 1-5 parts of ginger, 1-5 parts of jujube, 1-5 parts of yam, 1-5 parts of ebony, 1-5 parts of hawthorn, 1-5 parts of northern adenophora, 1-5 parts of tangerine peel, 20-30 parts of corn starch and 10-20 parts of lactose, and transfer them to a granulator for sieving;

[0029] Step 3: Product granulation: the raw materials prepared in step 2 are transferred into a fluidized bed granulator for premixing, and dry granules are obtained by discharging the materials;

[0030] Step 4: tabletting: the dry granules prepared in step 3 are put into a tablet press to form a finished product.

[0031] The sieving in step 2 is specifically performed with a sieve mesh aperture of 0.8 mm and a controlled rotation speed of 750-1000 rpm.

[0032] In step 3, the premixing is specifically to open the air volume at 20m / h, the fan frequency at 40Hz, and the inlet air temperature at 60-80℃. When the material temperature rises to 28-43, open the air volume at 20-80m / h, the fan frequency at 40Hz, and the inlet air temperature at 60-80℃.

[0033] The dry particles obtained in step 3 are continuously sprayed with the slurry prepared in step 1 and dried at an inlet air temperature of 70° C. The particles are discharged when the moisture content is controlled to be 1%-3%.

[0034] Embodiment 2:

[0035] See also Figure 1 The present invention provides a voglibose tablet for preventing gastric mucosal damage, comprising voglibose tablets, which include 1 part of codonopsis pilosula, 1 part of cinnamon bark, 1 part of licorice, 1 part of alum leaf, 1 part of elecampane, 1 part of fennel, 1 part of stir-fried alum leaf, 1 part of juniper paste, 1 part of licorice, 1 part of ginger, 1 part of jujube, 1 part of yam, 1 part of black plum, 1 part of hawthorn, 3 parts of northern adenophora, 3 parts of tangerine peel, 20 parts of corn starch, 30 parts of voglibose, 20 parts of lactose and 10 parts of hydroxypropyl cellulose.

[0036] The present invention provides a preparation process of a voglibose tablet for preventing gastric mucosal damage, comprising the following steps:

[0037] Step 1: Slurry preparation: slowly add 10 parts of hydroxypropyl cellulose into 60-80°C purified water to prepare a binder solution, start stirring, and after the binder is swollen, dissolved and defoamed, add 30 parts of the raw material voglibose, dissolve it, and set aside;

[0038] Step 2, raw material preparation: weigh 1 part of Codonopsis pilosula, 1 part of cinnamon bark, 1 part of licorice, 1 part of Alumensis leaf, 1 part of Inula japonica, 1 part of fennel, 1 part of stir-fried Alumen leaf, 1 part of Sabina paste, 1 part of licorice, 1 part of ginger, 1 part of jujube, 1 part of yam, 1 part of black plum, 1 part of hawthorn, 3 parts of Adenophora adenophora, 3 parts of dried tangerine peel, 20 parts of corn starch and 20 parts of lactose, and transfer them to a granulator for sieving;

[0039] Step 3: Product granulation: the raw materials prepared in step 2 are transferred into a fluidized bed granulator for premixing, and dry granules are obtained by discharging the materials;

[0040] Step 4: tabletting: the dry granules prepared in step 3 are put into a tablet press to form a finished product.

[0041] The sieving in step 2 is specifically performed with a sieve mesh aperture of 0.8 mm and a controlled rotation speed of 750-1000 rpm.

[0042] In step 3, the premixing is specifically to open the air volume at 20m / h, the fan frequency at 40Hz, and the inlet air temperature at 60-80℃. When the material temperature rises to 28-43, open the air volume at 20-80m / h, the fan frequency at 40Hz, and the inlet air temperature at 60-80℃.

[0043] The dry particles obtained in step 3 are continuously sprayed with the slurry prepared in step 1 and dried at an air inlet temperature of 70° C. The particles are discharged when the moisture content is controlled to be 1%-3%.

[0044] Embodiment 3:

[0045] See also Figure 1 The present invention provides a voglibose tablet for preventing gastric mucosal damage, comprising voglibose tablets, which include 1 part of codonopsis pilosula, 1 part of cinnamon bark, 1 part of licorice, 1 part of alum leaf, 1 part of elecampane, 1 part of fennel, 1 part of stir-fried alum leaf, 1 part of juniper paste, 1 part of licorice, 1 part of ginger, 1 part of jujube, 1 part of yam, 3 parts of black plum, 3 parts of hawthorn, 1 part of northern adenophora, 1 part of tangerine peel, 20 parts of corn starch, 30 parts of voglibose, 10 parts of lactose and 20 parts of hydroxypropyl cellulose.

[0046] The present invention provides a preparation process of a voglibose tablet for preventing gastric mucosal damage, comprising the following steps:

[0047] Step 1: Slurry preparation: slowly add 20 parts of hydroxypropyl cellulose into 60-80°C purified water to prepare a binder solution, start stirring, and after the binder is swollen, dissolved and defoamed, add 30 parts of the raw material voglibose, dissolve it, and set aside;

[0048] Step 2, prepare raw materials: 1 part of ginseng, 1 part of cinnamon, 1 part of licorice, 1 part of alum leaf, 1 part of elecampane, 1 part of fennel, 1 part of fried alum leaf, 1 part of juniper paste, 1 part of licorice, 1 part of ginger, 1 part of jujube, 1 part of yam, 3 parts of black plum, 3 parts of hawthorn, 1 part of northern adenophora, 1 part of tangerine peel, 20 parts of corn starch and 10 parts of lactose, transfer to a granulator and sieve;

[0049] Step 3: Product granulation: the raw materials prepared in step 2 are transferred into a fluidized bed granulator for premixing, and dry granules are obtained by discharging;

[0050] Step 4: tabletting: the dry granules prepared in step 3 are put into a tablet press to form a finished product.

[0051] The sieving in step 2 is specifically performed with a sieve mesh aperture of 0.8 mm and a controlled rotation speed of 750-1000 rpm.

[0052] In step 3, the premixing is specifically to open the air volume at 20m / h, the fan frequency at 40Hz, and the inlet air temperature at 60-80℃. When the material temperature rises to 28-43, open the air volume at 20-80m / h, the fan frequency at 40Hz, and the inlet air temperature at 60-80℃.

[0053] The dry particles obtained in step 3 are continuously sprayed with the slurry prepared in step 1 and dried at an inlet air temperature of 70° C. The particles are discharged when the moisture content is controlled to be 1%-3%.

[0054] Embodiment 4:

[0055] See also Figure 1 The present invention provides a voglibose tablet for preventing gastric mucosal damage, comprising voglibose tablets, which include 1 part of codonopsis pilosula, 1 part of cinnamon bark, 1 part of licorice, 1 part of alum leaf, 1 part of elecampane, 1 part of fennel, 1 part of stir-fried alum leaf, 1 part of juniper paste, 1 part of licorice, 1 part of ginger, 3 parts of jujube, 3 parts of yam, 1 part of ebony, 1 part of hawthorn, 1 part of northern adenophora, 1 part of tangerine peel, 30 parts of corn starch, 30 parts of voglibose, 10 parts of lactose and 10 parts of hydroxypropyl cellulose.

[0056] The present invention provides a preparation process of a voglibose tablet for preventing gastric mucosal damage, comprising the following steps:

[0057] Step 1: Slurry preparation: slowly add 10 parts of hydroxypropyl cellulose into 60-80°C purified water to prepare a binder solution, start stirring, and after the binder is swollen, dissolved and defoamed, add 30 parts of the raw material voglibose, dissolve it, and set aside;

[0058] Step 2, raw material preparation: weigh 1 part of Codonopsis pilosula, 1 part of cinnamon bark, 1 part of licorice, 1 part of Alumensis leaf, 1 part of Inula japonica, 1 part of fennel, 1 part of stir-fried Alumen leaf, 1 part of Sabina paste, 1 part of licorice, 1 part of ginger, 3 parts of jujube, 3 parts of yam, 1 part of black plum, 1 part of hawthorn, 1 part of Adenophora adenophora, 1 part of dried tangerine peel, 30 parts of corn starch and 10 parts of lactose, and transfer them to a granulator for sieving;

[0059] Step 3: Product granulation: the raw materials prepared in step 2 are transferred into a fluidized bed granulator for premixing, and dry granules are obtained by discharging the materials;

[0060] Step 4: tabletting: the dry granules prepared in step 3 are put into a tablet press to form a finished product.

[0061] The sieving in step 2 is specifically performed with a sieve mesh aperture of 0.8 mm and a controlled rotation speed of 750-1000 rpm.

[0062] In step 3, the premixing is specifically to open the air volume at 20m / h, the fan frequency at 40Hz, and the inlet air temperature at 60-80℃. When the material temperature rises to 28-43, open the air volume at 20-80m / h, the fan frequency at 40Hz, and the inlet air temperature at 60-80℃.

[0063] The dry particles obtained in step 3 are continuously sprayed with the slurry prepared in step 1 and dried at an air inlet temperature of 70° C. The particles are discharged when the moisture content is controlled to be 1%-3%.

[0064] Embodiment 5:

[0065] See also Figure 1 The present invention provides a voglibose tablet for preventing gastric mucosal damage, comprising voglibose tablets, which include 1 part of codonopsis pilosula, 1 part of cinnamon bark, 1 part of licorice, 1 part of alum leaf, 1 part of elecampane, 1 part of fennel, 1 part of stir-fried alum leaf, 1 part of juniper paste, 2 parts of licorice, 2 parts of ginger, 2 parts of jujube, 2 parts of yam, 1 part of ebony, 1 part of hawthorn, 1 part of northern adenophora, 1 part of tangerine peel, 20 parts of corn starch, 35 parts of voglibose, 10 parts of lactose and 15 parts of hydroxypropyl cellulose.

[0066] The present invention provides a preparation process of a voglibose tablet for preventing gastric mucosal damage, comprising the following steps:

[0067] Step 1: Slurry preparation: slowly add 15 parts of hydroxypropyl cellulose into 60-80°C purified water to prepare a binder solution, start stirring, and after the binder is swollen, dissolved and defoamed, add 35 parts of the raw material voglibose, dissolve it, and set aside;

[0068] Step 2, raw material preparation: weigh 1 part of Codonopsis pilosula, 1 part of cinnamon bark, 1 part of licorice, 1 part of Alumensis leaf, 1 part of Inula japonica, 1 part of fennel, 1 part of stir-fried Alumen leaf, 1 part of Sabina paste, 2 parts of licorice, 2 parts of ginger, 2 parts of jujube, 2 parts of yam, 1 part of black plum, 1 part of hawthorn, 1 part of Adenophora adenophora, 1 part of dried tangerine peel, 20 parts of corn starch and 10 parts of lactose, and transfer them to a granulator for sieving;

[0069] Step 3: Product granulation: the raw materials prepared in step 2 are transferred into a fluidized bed granulator for premixing, and dry granules are obtained by discharging;

[0070] Step 4: tabletting: the dry granules prepared in step 3 are put into a tablet press to form a finished product.

[0071] The sieving in step 2 is specifically performed with a sieve mesh aperture of 0.8 mm and a controlled rotation speed of 750-1000 rpm.

[0072] In step 3, the premixing is specifically to open the air volume at 20m / h, the fan frequency at 40Hz, and the inlet air temperature at 60-80℃. When the material temperature rises to 28-43, open the air volume at 20-80m / h, the fan frequency at 40Hz, and the inlet air temperature at 60-80℃.

[0073] The dry particles obtained in step 3 are continuously sprayed with the slurry prepared in step 1 and dried at an air inlet temperature of 70° C. The particles are discharged when the moisture content is controlled to be 1%-3%.

[0074] In the present invention, 10-20 parts of hydroxypropyl cellulose are slowly added into 60-80° C. purified water to prepare an adhesive solution, stirring is started, and after the adhesive is swollen, dissolved and defoamed, 30-50 parts of voglibose, a raw material drug, is added and dissolved for standby use, and 1-5 parts of codonopsis pilosula, 1-5 parts of cinnamon, 1-5 parts of licorice, 1-5 parts of alum leaves, 1-5 parts of elecampane, 1-5 parts of fennel, 1-5 parts of stir-fried alum leaves, 1-5 parts of juniper paste, 1-5 parts of licorice, 1-5 parts of ginger, 1-5 parts of jujube, 1-5 parts of yam, 1-5 parts of black plum, 1-5 parts of hawthorn, 1-5 parts of northern adenophora, 1-5 parts of tangerine peel, and corn starch are weighed. 20-30 parts of lactose and 10-20 parts of lactose are transferred to a granulator for sieving, the mesh size is 0.8mm, the speed is controlled to be 750-1000rpm, the prepared raw materials are transferred to a fluidized bed granulator for premixing, specifically, the air volume is opened at 20m / h, the fan frequency is 40Hz, and the inlet air temperature is 60-80°C. When the material temperature rises to 28-43, the air volume is opened at 20-80m / h, the fan frequency is 40Hz, and the inlet air temperature is 60-80°C, and the dry granules are discharged, the slurry is continuously sprayed and the inlet air temperature is 70°C for drying, and the moisture content is controlled to be 1%-3%, and the material is discharged, and the dry granules prepared in step 3 are put into a tablet press for tableting to obtain a finished product;

[0075] Codonopsis, cinnamon bark, liquorice, alum leaf, elecampane, fennel, stir-fried alum leaf and juniper paste have the effects of strengthening the spleen and stomach, regulating qi and harmonizing the middle, and are used to treat spleen and stomach weakness, abdominal pain caused by cold, and discomfort caused by ulcerative colitis. After taking them, they can protect the gastric mucosa.

[0076] Ginger and jujube have the effect of warming the middle and harmonizing the stomach. They are used to treat stomach pain and fullness caused by insufficient stomach yang and dampness blocking qi stagnation. Symptoms include dull stomach pain, abdominal distension, vomiting of acid water, loss of appetite, and fatigue in the limbs.

[0077] Chinese yam, black plum, hawthorn, and northern adenophora have the effect of nourishing yin and nourishing the stomach. They are used to treat chronic gastritis with symptoms such as burning in the stomach, dull pain, bloating, dry mouth, bitterness, loss of appetite, and discomfort caused by heat in the five parts of the body, thus protecting the gastric mucosa.

[0078] Codonopsis pilosula strengthens the spleen and stomach. It is a Qi-tonifying medicine that treats spleen and stomach weakness, lung deficiency and phlegm cough, while strengthening the spleen and stomach function and replenishing Qi; cinnamon bark has the effects of replenishing fire and yang, dispelling cold and relieving pain, and promoting blood circulation and menstruation; licorice prevents and relieves gastric ulcers, treats pharyngeal inflammation, relieves the stimulation of inflammatory substances, and makes phlegm easier to cough up; alum leaves are bitter and cold in nature, and belong to the liver, spleen, and stomach meridians. They have the effects of clearing away heat and detoxifying, drying dampness and relieving pain, and stopping diarrhea; turmeric enters the spleen and stomach, has the effect of nourishing the spleen and stomach, and is used to treat indigestion, loss of appetite, food accumulation, abdominal distension, and constipation caused by spleen and stomach disharmony; fennel is a commonly used Chinese herbal medicine that has the effects of strengthening the stomach and digestion, relieving abdominal pain, improving respiratory health, and antibacterial effects; fried alum leaves have the effects of strengthening the spleen and stomach, regulating Qi and middle effect; Juniper paste is a Chinese medicinal material with a cold nature. Clearing away heat and detoxifying is its important effect. It can prevent the accumulation of heat and toxins in the human body and inhibit the body's absorption of heat and toxins; gingerol, cellulose and vitamins in ginger can relieve digestive problems when consumed in moderation, and have a warming effect on the stomach and promote gastrointestinal motility; red dates have the effect of nourishing the stomach and strengthening the spleen; yam has the effect of strengthening the spleen and benefiting the stomach, and is suitable for loss of appetite and pain caused by stomach problems, and also has a positive significance for repairing gastric mucosa; black plum helps gastrointestinal motility, enhances gastrointestinal digestion and absorption capacity, and relieves stomach discomfort; hawthorn contains a variety of organic acids, which can speed up gastrointestinal motility, strengthen the spleen and appetite, digest food and eliminate accumulation, promote protein digestion, and help people with indigestion; Northern Adenophora can nourish stomach yin.

[0079] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A voglibose tablet for preventing gastric mucosal damage, comprising a voglibose tablet, characterized in that: The voglibose tablet comprises 1-5 parts of codonopsis pilosula, 1-5 parts of cinnamon bark, 1-5 parts of liquorice, 1-5 parts of alum leaves, 1-5 parts of elecampane, 1-5 parts of fennel, 1-5 parts of stir-fried alum leaves, 1-5 parts of juniper paste, 1-5 parts of liquorice, 1-5 parts of ginger, 1-5 parts of jujube, 1-5 parts of yam, 1-5 parts of black plum, 1-5 parts of hawthorn, 1-5 parts of northern adenophora, 1-5 parts of tangerine peel, 20-30 parts of corn starch, 30-50 parts of voglibose, 10-20 parts of lactose and 10-20 parts of hydroxypropyl cellulose.

2. The voglibose tablet for preventing gastric mucosal damage according to claim 1, characterized in that: The voglibose tablet comprises 1 part of codonopsis pilosula, 1 part of cinnamon bark, 1 part of liquorice, 1 part of alum leaf, 1 part of elecampane, 1 part of fennel, 1 part of stir-fried alum leaf, 1 part of juniper paste, 1 part of liquorice, 1 part of ginger, 1 part of jujube, 1 part of yam, 1 part of black plum, 1 part of hawthorn, 3 parts of northern adenophora, 3 parts of tangerine peel, 20 parts of corn starch, 30 parts of voglibose, 20 parts of lactose and 10 parts of hydroxypropyl cellulose.

3. The voglibose tablet for preventing gastric mucosal damage according to claim 1, characterized in that: The voglibose tablet comprises 1 part of codonopsis pilosula, 1 part of cinnamon bark, 1 part of liquorice, 1 part of alum leaf, 1 part of elecampane, 1 part of fennel, 1 part of stir-fried alum leaf, 1 part of juniper paste, 1 part of liquorice, 1 part of ginger, 1 part of jujube, 1 part of yam, 3 parts of black plum, 3 parts of hawthorn, 1 part of northern adenophora, 1 part of tangerine peel, 20 parts of corn starch, 30 parts of voglibose, 10 parts of lactose and 20 parts of hydroxypropyl cellulose.

4. The voglibose tablet for preventing gastric mucosal damage according to claim 1, characterized in that: The voglibose tablet comprises 1 part of codonopsis pilosula, 1 part of cinnamon bark, 1 part of liquorice, 1 part of alum leaf, 1 part of elecampane, 1 part of fennel, 1 part of stir-fried alum leaf, 1 part of juniper paste, 1 part of liquorice, 1 part of ginger, 3 parts of jujube, 3 parts of yam, 1 part of ebony, 1 part of hawthorn, 1 part of northern adenophora, 1 part of tangerine peel, 30 parts of corn starch, 30 parts of voglibose, 10 parts of lactose and 10 parts of hydroxypropyl cellulose.

5. The voglibose tablet for preventing gastric mucosal damage according to claim 1, characterized in that: The voglibose tablet comprises 1 part of codonopsis pilosula, 1 part of cinnamon bark, 1 part of liquorice, 1 part of alum leaf, 1 part of elecampane, 1 part of fennel, 1 part of stir-fried alum leaf, 1 part of juniper paste, 2 parts of liquorice, 2 parts of ginger, 2 parts of jujube, 2 parts of yam, 1 part of ebony, 1 part of hawthorn, 1 part of northern adenophora, 1 part of tangerine peel, 20 parts of corn starch, 35 parts of voglibose, 10 parts of lactose and 15 parts of hydroxypropyl cellulose.

6. The preparation process of a voglibose tablet for preventing gastric mucosal damage according to any one of claims 1 to 5, characterized in that: The following steps are involved: Step 1: Slurry preparation: slowly add 10-20 parts of hydroxypropyl cellulose into 60-80°C purified water to prepare a binder solution, start stirring, and after the binder is swollen, dissolved and defoamed, add 30-50 parts of the raw material voglibose, dissolve it, and set aside; Step 2, raw material preparation: weigh 1-5 parts of codonopsis pilosula, 1-5 parts of cinnamon, 1-5 parts of licorice, 1-5 parts of alum leaves, 1-5 parts of elecampane, 1-5 parts of fennel, 1-5 parts of stir-fried alum leaves, 1-5 parts of juniper paste, 1-5 parts of licorice, 1-5 parts of ginger, 1-5 parts of jujube, 1-5 parts of yam, 1-5 parts of ebony, 1-5 parts of hawthorn, 1-5 parts of northern adenophora, 1-5 parts of tangerine peel, 20-30 parts of corn starch and 10-20 parts of lactose, and transfer them to a granulator for sieving; Step 3: Product granulation: the raw materials prepared in step 2 are transferred into a fluidized bed granulator for premixing, and dry granules are obtained by discharging; Step 4: tabletting: the dry granules prepared in step 3 are put into a tablet press to form a finished product.

7. The preparation process of a voglibose tablet for preventing gastric mucosal damage according to claim 6, characterized in that: The sieving in step 2 specifically has a sieve mesh aperture of 0.8 mm and a controlled rotation speed of 750-1000 rpm.

8. The preparation process of the voglibose tablet for preventing gastric mucosal damage according to claim 6, characterized in that: The premixing in step 3 is specifically to open the air volume 20m / h, the fan frequency 40Hz, the inlet air temperature 60-80℃, and when the material temperature rises to 28-43, open the air volume 20-80m / h, the fan frequency 40Hz, and the inlet air temperature 60-80℃.

9. The preparation process of a voglibose tablet for preventing gastric mucosal damage according to claim 6, characterized in that: The dry particles obtained in step 3 are continuously sprayed with the slurry prepared in step 1 and dried at an inlet air temperature of 70° C. The particles are discharged when the moisture content is controlled to be 1%-3%.

Images