Extraction device and extraction process for extracting beta-nicotinamide mononucleotide
By designing an extraction device containing extraction, purification and crystallization mechanism, the problem of toxic substances in the catalytic reaction is solved, the extraction efficiency and purity of β-nicotinamide single nucleotides is improved, and the uniformity of crystalline particles and easy packaging and storage are ensured.
Patent Information
- Application Number
- CN202510148298.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-11
- Publication Date
- 2025-03-14
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The existing extraction devices and extraction processes for extracting β-nicotinamide single nucleotides will produce toxic substances in the catalytic reaction, resulting in a reduced catalytic efficiency of the equipment and a different size of the crystalline particles, making it difficult to package and store.
An extraction device including an extraction mechanism, a purification mechanism and a crystallization mechanism is designed. The toxic substances are adsorbed through the storage box, and the resin separation column is purified. The crystal barrel is combined with the crystallization improvement agent box to improve the crystallization effect.
It effectively removes toxic substances generated in the catalytic reaction, improves the extraction efficiency and purity of β-nicotinamide single nucleotides, ensures the uniformity of crystalline particles and is easy to package and store.
Smart Images

Figure CN119607700A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of β-nicotinamide mononucleotide, and in particular to an extraction device and an extraction process for extracting β-nicotinamide mononucleotide. Background Art
[0002] β-Nicotinamide mononucleotide is the product of the nicotinamide phosphoribosyltransferase reaction and is one of the key prerequisites for NAD+ synthesis. NAD+ is a key coenzyme in cellular energy metabolism and adaptive responses to oxidative stress. The NAD+-centered theory of mammalian aging believes that NAD+ levels determine the speed and extent of aging. NAD+ is present in all cells of the human body and is an important cofactor or cosubstrate that can be used in a variety of enzymatic processes, including glycolysis, TCA cycle, oxidative phosphorylation, DNA repair, and protein deacetylation. NAD+ levels are important for maintaining mitochondrial homeostasis, the metabolism of organisms, the normal function of organs and tissues, and delaying aging.
[0003] In the existing extraction device and extraction process for extracting β-nicotinamide mononucleotide, toxic substances will appear when the β-nicotinamide mononucleotide raw material reacts with the catalytic enzyme, and the staff needs to use other equipment to detoxify it, which reduces the catalytic efficiency of the equipment. At the same time, the β-nicotinamide mononucleotide solution is directly dried after crystallization, and the produced β-nicotinamide mononucleotide crystal particles are of different sizes and are not easy to package and store.
[0004] To this end, the present invention provides an extraction device and an extraction process for extracting β-nicotinamide mononucleotide to solve the above problems. Summary of the invention
[0005] In view of the deficiencies in the prior art, the present invention provides an extraction device and an extraction process for extracting β-nicotinamide mononucleotide, which solve the above problems.
[0006] To achieve the above objectives, the present invention is implemented by the following technical scheme: an extraction device for extracting β-nicotinamide mononucleotide, comprising: An extraction mechanism, the extraction mechanism is used to extract β-nicotinamide mononucleotide, and a carrying tray arranged at the bottom of the extraction mechanism; A purification mechanism, the purification mechanism is used to purify the β-nicotinamide mononucleotide solution; A crystallization mechanism, the crystallization mechanism is used to crystallize a β-nicotinamide mononucleotide solution; The top of the carrying tray is fixedly connected to the bottom of the extraction mechanism, the bottom of the purification mechanism is fixedly connected to the top of the carrying tray, the bottom of the crystallization mechanism is fixedly connected to the top of the carrying tray, the side wall of the extraction mechanism is connected to one end of the purification mechanism, and the bottom of the purification mechanism is connected to one end of the crystallization mechanism; Wherein, the extraction mechanism comprises: An extraction cylinder, and a feed pipe and a catalytic enzyme feed pipe arranged on the top of the extraction cylinder; A liquid discharge ring, and a liquid storage ring arranged at the bottom of the liquid discharge ring; A driving motor and a transmission shaft arranged at the bottom of the driving motor; A stirring blade, and a temperature controller arranged on the side wall of the stirring blade; The bottom of the liquid storage ring is fixedly connected to the top of the carrying tray, the top of the liquid storage ring is fixedly connected to the bottom of the extraction cylinder, the bottom of the extraction cylinder is communicated with the top of the liquid discharge ring, the top of the extraction cylinder is fixedly connected to a drive motor, the output end of the drive motor is fixedly connected to a transmission shaft, the side wall of the transmission shaft is fixedly connected to a stirring blade, the side wall of the stirring blade is fixedly connected to a temperature controller, the top of the extraction cylinder is communicated with the bottom of the feed pipe, and the top of the extraction cylinder is communicated with the bottom of the catalytic enzyme inlet pipe.
[0007] Preferably: the extraction mechanism also includes a discharge pipe, the bottom of the extraction cylinder is connected to the discharge pipe, the discharge pipe is provided with a first solenoid valve, the top of the extraction cylinder is fixedly connected to a storage box, the inside of the extraction cylinder is fixedly connected to a filter screen, the inside of the extraction cylinder is fixedly connected to a rotating sealing plate, and the top of the inner wall of the extraction cylinder is fixedly connected to a first annular slide rail.
[0008] Preferably: the first annular slide rail is slidably connected to the rotating sealing plate via an electronic slider, the top of the rotating sealing plate is rotatably connected to the inner wall of the extraction cylinder, the side wall of the stirring blade is rotatably connected to the inner wall of the filter screen, and the side wall of the filter screen is rotatably connected to the inner wall of the rotating sealing plate.
[0009] Preferably: the purification mechanism includes a liquid extraction tube, the side wall of the liquid storage ring is connected to one end of the liquid extraction tube, the other end of the liquid extraction tube is connected to a water pump, the other side of the water pump is connected to a liquid outlet pipe, the bottom of the water pump is fixedly connected to a purification cylinder, the inner wall of the purification cylinder is connected to a fixed vertical pipe, the top of the inner wall of the purification cylinder is fixedly connected to a first electric push rod, the bottom of the fixed vertical pipe is connected to a first sealing cylinder, the bottom of the purification cylinder is connected to an infusion tube, the bottom of the purification cylinder is connected to a waste liquid discharge pipe, the bottom of the inner wall of the purification cylinder is fixedly connected to a second annular slide rail, the second annular slide rail is slidably connected to a resin separation column through an electronic slider, the bottom of the purification cylinder is fixedly connected to a first connecting rod, the top of the inner wall of the purification cylinder is fixedly connected to a regeneration agent storage box, the bottom of the regeneration agent storage box is connected to a telescopic vertical pipe, the bottom of the telescopic vertical pipe is connected to a second sealing cylinder, and the bottom of the regeneration agent storage box is fixedly connected to a second electric push rod.
[0010] Preferably: the bottom of the second electric push rod is fixedly connected to the top of the second sealing tube, the bottom of the first electric push rod is fixedly connected to the top of the first sealing tube, the inner wall of the first sealing tube is movably connected to the side wall of the resin separation column, the inner wall of the second sealing tube is movably connected to the side wall of the resin separation column, the bottom of the liquid outlet pipe is connected to the top of the fixed vertical pipe, and the bottom of the first connecting rod is fixedly connected to the top of the supporting tray.
[0011] Preferably: the crystallization mechanism includes a connecting hose, the bottom of the infusion tube is connected to one end of the connecting hose, the other end of the connecting hose is connected to a crystallization cylinder, the bottom of the crystallization cylinder is fixedly connected to a second connecting rod, the top of the crystallization cylinder is fixedly connected to a crystal habit improver box, the bottom of the crystal habit improver box is connected to a conveying pipe, the inner wall of the crystallization cylinder is fixedly connected to a heating plate, the top of the heating plate is fixedly connected to a third annular slide rail, the third annular slide rail is slidably connected to a rotating circular plate through an electronic slider, the top of the rotating circular plate is fixedly connected to a temperature monitor, the side wall of the crystallization cylinder is connected to a drawing pipe, and the drawing pipe is provided with a second solenoid valve.
[0012] Preferably, the bottom of the second connecting rod is fixedly connected to the top of the carrying tray, the side wall of the rotating circular plate is rotatably connected to the inner wall of the crystallization cylinder, and the conveying pipe passes through the crystallization cylinder.
[0013] An extraction process for extracting β-nicotinamide mononucleotide comprises the following steps: S1. The staff inputs the β-nicotinamide mononucleotide raw material and the catalytic enzyme into the extraction tube and performs a catalytic reaction to extract the β-nicotinamide mononucleotide solution; S2, starting the storage box to inject activated carbon into the extraction cylinder to remove toxic substances produced during the extraction process of the β-nicotinamide mononucleotide solution; S3, the β-nicotinamide mononucleotide solution enters the first sealed cylinder, and the resin separation column purifies the β-nicotinamide mononucleotide solution; S4, the β-nicotinamide mononucleotide solution enters the crystallization cylinder for crystallization, and the crystal habit modifier box is started to inject the crystal habit modifier into the β-nicotinamide mononucleotide crystals to improve the crystallization effect of the β-nicotinamide mononucleotide.
[0014] The present invention provides an extraction device and extraction process for extracting β-nicotinamide mononucleotide. Compared with the prior art, it has the following beneficial effects: (1) The extraction device and extraction process for extracting β-nicotinamide mononucleotide can improve the catalytic reaction rate of β-nicotinamide mononucleotide raw material and catalytic enzyme through the cooperation of the storage box, the driving motor, the transmission shaft, the stirring blade, the filter screen, the rotating sealing plate, the first annular slide rail and the extraction cylinder, and can also adsorb the toxic substances generated during the extraction of β-nicotinamide mononucleotide solution, without the need for staff to use other equipment to detoxify it later.
[0015] (2) The extraction device and extraction process for extracting β-nicotinamide mononucleotide can purify the β-nicotinamide mononucleotide solution through the cooperation of the first electric push rod, the first sealing cylinder, the resin separation column, the second annular slide rail, the regeneration agent storage box, the telescopic vertical tube, the second electric push rod and the second sealing cylinder to prevent the impurities inside the solution from affecting the subsequent crystallization, and the regeneration agent can be injected into the resin separation column for maintenance to prevent the resin separation column from working for a long time and reducing the purification effect, thereby extending the service life of the resin separation column.
[0016] (3) The extraction device and extraction process for extracting β-nicotinamide mononucleotide can ensure that the internal temperature of the crystallization cylinder is always within the optimal temperature range for drying β-nicotinamide mononucleotide crystals through the cooperation of the crystallization cylinder, the crystal habit modifier box, the conveying pipe, the heating plate, the third annular slide rail and the rotating circular plate, and the crystal habit modifier can be introduced into the β-nicotinamide mononucleotide crystals, so that the β-nicotinamide mononucleotide crystal particles have a higher density, are less likely to generate static electricity, and are easy to store and package. BRIEF DESCRIPTION OF THE DRAWINGS
[0017] Figure 1 It is a schematic structural diagram of an extraction device and an extraction process for extracting β-nicotinamide mononucleotide according to the present invention; Figure 2 It is a structural schematic diagram of the extraction mechanism of the present invention; Figure 3 It is a schematic diagram of the position structure of the discharge pipe of the present invention; Figure 4 It is a schematic diagram of the structure of the purification mechanism of the present invention; Figure 5 It is a schematic diagram of the structure of the crystallization mechanism of the present invention; Figure 6 It is a schematic diagram of the position structure of the material extraction pipe of the present invention.
[0018] In the figure: 1, carrier tray; 2, extraction mechanism; 3, purification mechanism; 4, crystallization mechanism; 20, liquid storage ring; 21, extraction cylinder; 211, feed pipe; 212, catalytic enzyme feed pipe; 213, discharge ring; 214, discharge pipe; 215, first solenoid valve; 22, drive motor; 23, transmission shaft; 24, stirring blade; 25, temperature controller; 26, filter screen; 27, rotating sealing plate; 28, first annular slide rail; 29, storage box; 30, liquid extraction pipe; 301, water pump; 302, liquid outlet pipe; 31, purification cylinder; 311, first connection Rod; 312, infusion tube; 313, waste liquid discharge pipe; 32, fixed vertical pipe; 33, first electric push rod; 34, first sealing cylinder; 35, resin separation column; 36, second annular slide rail; 37, regeneration agent storage box; 371, telescopic vertical pipe; 38, second electric push rod; 39, second sealing cylinder; 40, connecting hose; 41, crystallization cylinder; 42, crystal habit improver box; 43, delivery pipe; 44, heating plate; 45, third annular slide rail; 46, rotating circular plate; 47, temperature monitor; 48, second connecting rod; 49, extraction pipe; 491, second solenoid valve. DETAILED DESCRIPTION
[0019] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0020] Embodiment 1: See also Figure 1-Figure 3 , an extraction device for extracting β-nicotinamide mononucleotide, comprising: An extraction mechanism (2), the extraction mechanism (2) being used to extract β-nicotinamide mononucleotide, and a carrying tray (1) arranged at the bottom of the extraction mechanism (2); A purification mechanism (3), the purification mechanism (3) is used to purify the β-nicotinamide mononucleotide solution; A crystallization mechanism (4), the crystallization mechanism (4) is used to crystallize a β-nicotinamide mononucleotide solution; The top of the carrying tray (1) is fixedly connected to the bottom of the extraction mechanism (2), the bottom of the purification mechanism (3) is fixedly connected to the top of the carrying tray (1), the bottom of the crystallization mechanism (4) is fixedly connected to the top of the carrying tray (1), the side wall of the extraction mechanism (2) is connected to one end of the purification mechanism (3), and the bottom of the purification mechanism (3) is connected to one end of the crystallization mechanism (4); Wherein, the extraction mechanism (2) comprises: An extraction cylinder (21), and a feed pipe (211) and a catalytic enzyme feed pipe (212) arranged at the top of the extraction cylinder (21); A liquid discharge ring (213), and a liquid storage ring (20) arranged at the bottom of the liquid discharge ring (213); A driving motor (22), and a transmission shaft (23) arranged at the bottom of the driving motor (22); A stirring blade (24), and a temperature controller (25) arranged on a side wall of the stirring blade (24); The bottom of the liquid storage ring (20) is fixedly connected to the top of the carrying tray (1), the top of the liquid storage ring (20) is fixedly connected to the bottom of the extraction cylinder (21), the bottom of the extraction cylinder (21) is connected to the top of the liquid discharge ring (213), the top of the extraction cylinder (21) is fixedly connected to a drive motor (22), the output end of the drive motor (22) is fixedly connected to a transmission shaft (23), the side wall of the transmission shaft (23) is fixedly connected to a stirring blade (24), the side wall of the stirring blade (24) is fixedly connected to a temperature controller (25), the top of the extraction cylinder (21) is connected to the bottom of the feed pipe (211), and the top of the extraction cylinder (21) is connected to the bottom of the catalytic enzyme inlet pipe (212); The extraction mechanism (2) further comprises a discharge pipe (214), the bottom of the extraction cylinder (21) is connected to the discharge pipe (214), the discharge pipe (214) is provided with a first solenoid valve (215), the top of the extraction cylinder (21) is fixedly connected to a storage box (29), the interior of the extraction cylinder (21) is fixedly connected to a filter screen (26), the interior of the extraction cylinder (21) is fixedly connected to a rotating sealing plate (27), the top of the inner wall of the extraction cylinder (21) is fixedly connected to a first annular slide rail (28), the first annular slide rail (28) and the rotating sealing plate (27) are slidably connected via an electronic slider, the top of the rotating sealing plate (27) is rotatably connected to the inner wall of the extraction cylinder (21), the side wall of the stirring blade (24) is rotatably connected to the inner wall of the filter screen (26), and the side wall of the filter screen (26) is rotatably connected to the inner wall of the rotating sealing plate (27); It should be noted that the staff inputs the β-nicotinamide mononucleotide raw material and the catalytic enzyme into the extraction cylinder 21 through the feed pipe 211 and the catalytic enzyme inlet pipe 212 respectively, starts the temperature controller 25 to adjust the internal ambient temperature of the extraction cylinder 21 to a temperature suitable for the catalytic reaction of the β-nicotinamide mononucleotide raw material, starts the drive motor 22, and the drive motor 22 drives the stirring blade 24 to rotate through the transmission shaft 23 to stir and mix the β-nicotinamide mononucleotide raw material and the catalytic enzyme, thereby further improving the catalytic reaction efficiency of the equipment. The catalytic reaction between the β-nicotinamide mononucleotide raw material and the catalytic enzyme will produce toxic substances, and starts the storage box 29. The storage box 29 inputs the internal activated carbon into the extraction cylinder 21 and mixes with the activated carbon. The β-nicotinamide mononucleotide solution is mixed to adsorb and separate the toxic substances inside it. When the reaction of the β-nicotinamide mononucleotide solution is completed, the first annular slide rail 28 is started, and the first annular slide rail 28 drives the rotating sealing plate 27 to rotate and open the filter screen 26. When the stirring blade 24 rotates, it drives the β-nicotinamide mononucleotide solution and the activated carbon particles to rotate. The β-nicotinamide mononucleotide solution is thrown out of the filter screen 26 under the action of centrifugal force. Under the influence of gravity, the β-nicotinamide mononucleotide solution enters the liquid storage ring 20 through the liquid discharge ring 213. When the β-nicotinamide mononucleotide solution is discharged, the first solenoid valve 215 is started, and the activated carbon particles are discharged through the discharge pipe 214.
[0021] Embodiment 2: See also Figure 4, an extraction device for extracting β-nicotinamide mononucleotide, the purification mechanism (3) comprising a liquid extraction tube (30), the side wall of the liquid storage ring (20) being connected to one end of the liquid extraction tube (30), the other end of the liquid extraction tube (30) being connected to a water pump (301), the other side of the water pump (301) being connected to a liquid outlet tube (302), the bottom of the water pump (301) being fixedly connected to a purification cylinder (31), the inner wall of the purification cylinder (31) being connected to a fixed vertical pipe (32) The top of the inner wall of the purification cylinder (31) is fixedly connected to a first electric push rod (33), the bottom of the fixed vertical pipe (32) is connected to a first sealing cylinder (34), the bottom of the purification cylinder (31) is connected to a liquid infusion tube (312), the bottom of the purification cylinder (31) is connected to a waste liquid discharge tube (313), the bottom of the inner wall of the purification cylinder (31) is fixedly connected to a second annular slide rail (36), and the second annular slide rail (36) is slidably connected to a resin separation column via an electronic slider. (35), the bottom of the purification cylinder (31) is fixedly connected to a first connecting rod (311), the top of the inner wall of the purification cylinder (31) is fixedly connected to a regeneration agent storage box (37), the bottom of the regeneration agent storage box (37) is connected to a telescopic vertical pipe (371), the bottom of the telescopic vertical pipe (371) is connected to a second sealing cylinder (39), the bottom of the regeneration agent storage box (37) is fixedly connected to a second electric push rod (38), the bottom of the second electric push rod (38) is fixedly connected to the top of the second sealing cylinder (39), the bottom of the first electric push rod (33) is fixedly connected to the top of the first sealing cylinder (34), the inner wall of the first sealing cylinder (34) is movably connected to the side wall of the resin separation column (35), the inner wall of the second sealing cylinder (39) is movably connected to the side wall of the resin separation column (35), the bottom of the liquid outlet pipe (302) is connected to the top of the fixed vertical pipe (32), and the bottom of the first connecting rod (311) is fixedly connected to the top of the supporting tray (1); It should be noted that the water pump 301 is started, and the water pump 301 extracts the β-nicotinamide mononucleotide solution inside the liquid storage ring 20 through the liquid extraction tube 30 and inputs it into the first sealing cylinder 34 through the liquid outlet tube 302 and the fixed vertical tube 32. The β-nicotinamide mononucleotide solution flows into the resin separation column 35 under the influence of gravity. The resin separation column 35 adsorbs and purifies the impurities inside the β-nicotinamide mononucleotide solution. After the β-nicotinamide mononucleotide solution is purified, it flows into the infusion tube 312 under the influence of gravity. When the resin separation column 35 purifies the β-nicotinamide mononucleotide solution for a long time, the cleaning effect of the resin separation column 35 gradually becomes poor, and the first electric push rod 33 and the second electric push rod are started. 38. The first electric push rod 33 and the second electric push rod 38 respectively drive the first sealing cylinder 34 and the second sealing cylinder 39 to rise away from the resin separation column 35, and start the second annular slide rail 36. The second annular slide rail 36 drives the two resin separation columns 35 to rotate and exchange positions. The first electric push rod 33 and the second electric push rod 38 drive the first sealing cylinder 34 and the second sealing cylinder 39 to reset, and start the regeneration agent storage box 37. The regeneration agent storage box 37 inputs the regeneration agent into the second sealing cylinder 39 through the telescopic vertical pipe 371 to repair the resin separation column 35, thereby increasing the service life of the resin separation column 35. While maintaining the resin separation column 35, it will not affect the normal operation of the equipment, thereby improving the purification efficiency of the device.
[0022] Embodiment three: See also Figure 5-Figure 6 , an extraction device for extracting β-nicotinamide mononucleotide, the crystallization mechanism (4) comprising a connecting hose (40), the bottom of the infusion tube (312) being connected to one end of the connecting hose (40), the other end of the connecting hose (40) being connected to a crystallization cylinder (41), the bottom of the crystallization cylinder (41) being fixedly connected to a second connecting rod (48), the top of the crystallization cylinder (41) being fixedly connected to a crystal habit modifier box (42), the bottom of the crystal habit modifier box (42) being connected to a delivery pipe (43), the inner wall of the crystallization cylinder (41) being fixedly connected to a heating plate (44), the heating plate ( 44) A third annular slide rail (45) is fixedly connected to the top, the third annular slide rail (45) is slidably connected to a rotating circular plate (46) through an electronic slider, the top of the rotating circular plate (46) is fixedly connected to a temperature monitor (47), the side wall of the crystallization cylinder (41) is connected to a pumping pipe (49), the pumping pipe (49) is provided with a second solenoid valve (491), the bottom of the second connecting rod (48) is fixedly connected to the top of the carrying tray (1), the side wall of the rotating circular plate (46) is rotatably connected to the inner wall of the crystallization cylinder (41), and the conveying pipe (43) passes through the crystallization cylinder (41); It should be noted that the β-nicotinamide mononucleotide solution in the infusion tube 312 is input into the crystallization cylinder 41 through the connecting hose 40, and the β-nicotinamide mononucleotide solution gradually crystallizes in the crystallization cylinder 41. When the β-nicotinamide mononucleotide solution is initially crystallized, the crystal habit modifier box 42 is started, and the crystal habit modifier box 42 inputs the crystal habit modifier into the crystallization cylinder 41 through the conveying tube 43 to mix with the β-nicotinamide mononucleotide crystals. The third annular slide 45 is started, and the third annular slide 45 drives the rotating circular plate 46 to rotate, so as to increase the reaction between the crystal habit modifier and the β-nicotinamide mononucleotide crystals, so that the β-nicotinamide mononucleotide crystal particles have a higher density, are less likely to generate static electricity, and are easy to store and package. The β-nicotinamide mononucleotide crystals can be dried by the cooperation of the heating plate 44 and the temperature monitor 47 without damaging the β-nicotinamide mononucleotide crystals. The second solenoid valve 491 is opened, and the extraction pipe 49 is started to extract the dried β-nicotinamide mononucleotide crystals, thereby improving the automation of the device.
[0023] Embodiment 4: See also Figure 1-Figure 6 , an extraction process for extracting β-nicotinamide mononucleotide, comprising the following steps: S1. The staff inputs the β-nicotinamide mononucleotide raw material and the catalytic enzyme into the extraction cylinder 21 and performs a catalytic reaction to extract the β-nicotinamide mononucleotide solution; S2, starting the storage box 29 to inject activated carbon into the extraction cylinder 21 to remove toxic substances produced in the β-nicotinamide mononucleotide solution during the extraction process; S3, the β-nicotinamide mononucleotide solution enters the first sealing cylinder 34, and the resin separation column 35 purifies the β-nicotinamide mononucleotide solution; S4, the β-nicotinamide mononucleotide solution enters the crystallization cylinder 41 for crystallization, and the crystal habit modifier box 42 is started to inject the crystal habit modifier into the β-nicotinamide mononucleotide crystals to improve the crystallization effect of the β-nicotinamide mononucleotide.
[0024] Meanwhile, the contents not described in detail in this specification belong to the prior art known to those skilled in the art.
[0025] During operation, the staff feeds the β-nicotinamide mononucleotide raw material and the catalytic enzyme into the extraction cylinder 21 through the feed pipe 211 and the catalytic enzyme feed pipe 212 respectively, starts the temperature controller 25 to adjust the internal ambient temperature of the extraction cylinder 21 to a temperature suitable for the catalytic reaction of the β-nicotinamide mononucleotide raw material, starts the drive motor 22, and the drive motor 22 drives the stirring blade 24 to rotate through the transmission shaft 23 to stir and mix the β-nicotinamide mononucleotide raw material and the catalytic enzyme, thereby further improving the catalytic reaction efficiency of the equipment. The catalytic reaction between the β-nicotinamide mononucleotide raw material and the catalytic enzyme will produce toxic substances, and starts the storage box 29. The storage box 29 inputs the internal activated carbon into the extraction cylinder 21 and mixes with the β-nicotinamide mononucleotide raw material. -nicotinamide mononucleotide solution is mixed to adsorb and separate the toxic substances inside it. When the reaction of the β-nicotinamide mononucleotide solution is completed, the first annular slide rail 28 is started, and the first annular slide rail 28 drives the rotating sealing plate 27 to rotate and open the filter screen 26. When the stirring blade 24 rotates, it drives the β-nicotinamide mononucleotide solution and the activated carbon particles to rotate. The β-nicotinamide mononucleotide solution is thrown out of the filter screen 26 under the action of centrifugal force. Under the influence of gravity, the β-nicotinamide mononucleotide solution enters the liquid storage ring 20 through the liquid discharge ring 213. When the β-nicotinamide mononucleotide solution is discharged, the first electromagnetic valve 215 is started, and the activated carbon particles are discharged through the discharge pipe 214; The water pump 301 is started. The water pump 301 extracts the β-nicotinamide mononucleotide solution in the liquid storage ring 20 through the liquid extraction pipe 30 and inputs it into the first sealing cylinder 34 through the liquid outlet pipe 302 and the fixed vertical pipe 32. The β-nicotinamide mononucleotide solution flows into the resin separation column 35 under the influence of gravity. The resin separation column 35 adsorbs and purifies the impurities in the β-nicotinamide mononucleotide solution. After the β-nicotinamide mononucleotide solution is purified, it flows into the infusion pipe 312 under the influence of gravity. When the resin separation column 35 purifies the β-nicotinamide mononucleotide solution for a long time, the cleaning effect of the resin separation column 35 gradually becomes poor. The first electric push rod 33 and the second electric push rod 38 are started. The first electric push rod 33 and the second electric push rod 38 respectively drive the first sealing cylinder 34 and the second sealing cylinder 39 to rise away from the resin separation column 35, and start the second annular slide rail 36. The second annular slide rail 36 drives the two resin separation columns 35 to rotate and exchange positions. The first electric push rod 33 and the second electric push rod 38 drive the first sealing cylinder 34 and the second sealing cylinder 39 to reset, and start the regeneration agent storage box 37. The regeneration agent storage box 37 inputs the regeneration agent into the resin separation column 35 inside the second sealing cylinder 39 through the telescopic vertical pipe 371 to repair it, thereby increasing the service life of the resin separation column 35. While maintaining the resin separation column 35, it will not affect the normal operation of the equipment, thereby improving the purification efficiency of the device; The β-nicotinamide mononucleotide solution in the infusion tube 312 is input into the crystallization cylinder 41 through the connecting hose 40, and the β-nicotinamide mononucleotide solution gradually crystallizes in the crystallization cylinder 41. When the β-nicotinamide mononucleotide solution is initially crystallized, the crystal habit modifier box 42 is started, and the crystal habit modifier box 42 inputs the crystal habit modifier into the crystallization cylinder 41 through the conveying tube 43 to mix with the β-nicotinamide mononucleotide crystals. The third annular slide 45 is started, and the third annular slide 45 drives the rotating circular plate 46 to rotate, so as to increase the reaction between the crystal habit modifier and the β-nicotinamide mononucleotide crystals, so that the β-nicotinamide mononucleotide crystal particles have a higher density, are less likely to generate static electricity, and are easy to store and package. The β-nicotinamide mononucleotide crystals can be dried by the cooperation of the heating plate 44 and the temperature monitor 47 without damaging the β-nicotinamide mononucleotide crystals. The second solenoid valve 491 is opened, and the extraction pipe 49 is started to extract the dried β-nicotinamide mononucleotide crystals, thereby improving the automation of the device.
[0026] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.
[0027] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. An extraction device for extracting β-nicotinamide mononucleotide, characterized in that: include: An extraction mechanism (2), the extraction mechanism (2) being used to extract β-nicotinamide mononucleotide, and a carrying tray (1) arranged at the bottom of the extraction mechanism (2); A purification mechanism (3), the purification mechanism (3) is used to purify the β-nicotinamide mononucleotide solution; A crystallization mechanism (4), the crystallization mechanism (4) is used to crystallize a β-nicotinamide mononucleotide solution; The top of the carrying tray (1) is fixedly connected to the bottom of the extraction mechanism (2), the bottom of the purification mechanism (3) is fixedly connected to the top of the carrying tray (1), the bottom of the crystallization mechanism (4) is fixedly connected to the top of the carrying tray (1), the side wall of the extraction mechanism (2) is connected to one end of the purification mechanism (3), and the bottom of the purification mechanism (3) is connected to one end of the crystallization mechanism (4); Wherein, the extraction mechanism (2) comprises: An extraction cylinder (21), and a feed pipe (211) and a catalytic enzyme feed pipe (212) arranged at the top of the extraction cylinder (21); A liquid discharge ring (213), and a liquid storage ring (20) arranged at the bottom of the liquid discharge ring (213); A driving motor (22), and a transmission shaft (23) arranged at the bottom of the driving motor (22); A stirring blade (24), and a temperature controller (25) arranged on a side wall of the stirring blade (24); The bottom of the liquid storage ring (20) is fixedly connected to the top of the carrying tray (1), the top of the liquid storage ring (20) is fixedly connected to the bottom of the extraction cylinder (21), the bottom of the extraction cylinder (21) is connected to the top of the liquid discharge ring (213), the top of the extraction cylinder (21) is fixedly connected to a drive motor (22), the output end of the drive motor (22) is fixedly connected to a transmission shaft (23), the side wall of the transmission shaft (23) is fixedly connected to a stirring blade (24), the side wall of the stirring blade (24) is fixedly connected to a temperature controller (25), the top of the extraction cylinder (21) is connected to the bottom of the feed pipe (211), and the top of the extraction cylinder (21) is connected to the bottom of the catalytic enzyme feed pipe (212).
2. The extraction device for extracting β-nicotinamide mononucleotide according to claim 1, characterized in that: The extraction mechanism (2) further comprises a discharge pipe (214), the bottom of the extraction cylinder (21) is connected to the discharge pipe (214), a first solenoid valve (215) is provided on the discharge pipe (214), the top of the extraction cylinder (21) is fixedly connected to a storage box (29), the interior of the extraction cylinder (21) is fixedly connected to a filter screen (26), the interior of the extraction cylinder (21) is fixedly connected to a rotating sealing plate (27), and the top of the inner wall of the extraction cylinder (21) is fixedly connected to a first annular slide rail (28).
3. The extraction device for extracting β-nicotinamide mononucleotide according to claim 2, characterized in that: The first annular slide rail (28) is slidably connected to the rotating sealing plate (27) via an electronic slider, the top of the rotating sealing plate (27) is rotatably connected to the inner wall of the extraction cylinder (21), the side wall of the stirring blade (24) is rotatably connected to the inner wall of the filter screen (26), and the side wall of the filter screen (26) is rotatably connected to the inner wall of the rotating sealing plate (27).
4. The extraction device for extracting β-nicotinamide mononucleotide according to claim 1, characterized in that: The purification mechanism (3) comprises a liquid extraction tube (30), the side wall of the liquid storage ring (20) is connected to one end of the liquid extraction tube (30), the other end of the liquid extraction tube (30) is connected to a water pump (301), the other side of the water pump (301) is connected to a liquid outlet tube (302), the bottom of the water pump (301) is fixedly connected to a purification cylinder (31), the inner wall of the purification cylinder (31) is connected to a fixed vertical pipe (32), the top of the inner wall of the purification cylinder (31) is fixedly connected to a first electric push rod (33), the bottom of the fixed vertical pipe (32) is connected to a first sealing cylinder (34), the bottom of the purification cylinder (31) is connected to a liquid infusion tube (312), and the purification cylinder (31) is connected to a liquid infusion tube (312). The bottom of the cylinder (31) is connected to a waste liquid discharge pipe (313); the bottom of the inner wall of the purification cylinder (31) is fixedly connected to a second annular slide rail (36); the second annular slide rail (36) is slidably connected to a resin separation column (35) via an electronic slider; the bottom of the purification cylinder (31) is fixedly connected to a first connecting rod (311); the top of the inner wall of the purification cylinder (31) is fixedly connected to a regeneration agent storage box (37); the bottom of the regeneration agent storage box (37) is connected to a telescopic vertical pipe (371); the bottom of the telescopic vertical pipe (371) is connected to a second sealing cylinder (39); the bottom of the regeneration agent storage box (37) is fixedly connected to a second electric push rod (38).
5. The extraction device for extracting β-nicotinamide mononucleotide according to claim 4, characterized in that: The bottom of the second electric push rod (38) is fixedly connected to the top of the second sealing cylinder (39), the bottom of the first electric push rod (33) is fixedly connected to the top of the first sealing cylinder (34), the inner wall of the first sealing cylinder (34) is movably connected to the side wall of the resin separation column (35), the inner wall of the second sealing cylinder (39) is movably connected to the side wall of the resin separation column (35), the bottom of the liquid outlet pipe (302) is connected to the top of the fixed vertical pipe (32), and the bottom of the first connecting rod (311) is fixedly connected to the top of the supporting tray (1).
6. The extraction device for extracting β-nicotinamide mononucleotide according to claim 4, characterized in that: The crystallization mechanism (4) comprises a connecting hose (40), the bottom of the infusion tube (312) is connected to one end of the connecting hose (40), the other end of the connecting hose (40) is connected to a crystallization cylinder (41), the bottom of the crystallization cylinder (41) is fixedly connected to a second connecting rod (48), the top of the crystallization cylinder (41) is fixedly connected to a crystal habit modifier box (42), the bottom of the crystal habit modifier box (42) is connected to a delivery pipe (43), the inner wall of the crystallization cylinder (41) is fixedly connected to a heating plate (44), the top of the heating plate (44) is fixedly connected to a third annular slide rail (45), the third annular slide rail (45) is slidably connected to a rotating circular plate (46) via an electronic slider, the top of the rotating circular plate (46) is fixedly connected to a temperature monitor (47), the side wall of the crystallization cylinder (41) is connected to a material extraction pipe (49), and the material extraction pipe (49) is provided with a second solenoid valve (491).
7. The extraction device for extracting β-nicotinamide mononucleotide according to claim 6, characterized in that: The bottom of the second connecting rod (48) is fixedly connected to the top of the carrying tray (1), the side wall of the rotating circular plate (46) is rotatably connected to the inner wall of the crystallization cylinder (41), and the conveying pipe (43) passes through the crystallization cylinder (41).
8. An extraction process for extracting β-nicotinamide mononucleotide, applied to an extraction device for extracting β-nicotinamide mononucleotide as claimed in any one of claims 1 to 7, characterized in that: The following steps are involved: S1. A staff member inputs a β-nicotinamide mononucleotide raw material and a catalytic enzyme into an extraction cylinder (21) and performs a catalytic reaction to extract a β-nicotinamide mononucleotide solution; S2, starting the storage box (29) to inject activated carbon into the extraction cylinder (21) to remove toxic substances produced in the β-nicotinamide mononucleotide solution during the extraction process; S3, the β-nicotinamide mononucleotide solution enters the first sealed cylinder (34), and the resin separation column (35) purifies the β-nicotinamide mononucleotide solution; S4, the β-nicotinamide mononucleotide solution enters the crystallization cylinder (41) for crystallization, and the crystal habit modifier box (42) is started to inject the crystal habit modifier into the β-nicotinamide mononucleotide crystals to improve the crystallization effect of the β-nicotinamide mononucleotide.
Citation Information
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