Liquid chromatograph convenient to operate

Abstract

The invention belongs to the technical field of liquid chromatographs, and particularly relates to a liquid chromatograph convenient to operate, which comprises a chromatograph body, a bearing assembly and a liquid storage assembly, the bearing assembly comprises a base; the upper side of the base is fixedly connected with a supporting cylinder; the top of the supporting cylinder is fixedly connected with a trumpet-shaped bracket; the liquid storage assembly comprises a reagent bottle; a liquid inlet bottle opening is formed in the top of the reagent bottle, and a liquid outlet bottle opening is formed in the bottom; the interior of the liquid inlet bottle opening is in threaded connection with a plugging block; the reagent bottle is supported through the bearing assembly, the stability of the reagent bottle during placement is improved through mutual cooperation of the supporting cylinder and the bracket, the reagent bottle is used for storing a mobile phase solvent, after the solvent in the reagent bottle is used up, the plugging block can be screwed out upwards, and then the mobile phase solvent is added into the reagent bottle through the liquid inlet bottle opening; therefore, the reagent bottle does not need to be detached and replaced, the solvent adding step is simplified, and the operation process is convenient.

Description

Technical Field

[0001] The invention belongs to the technical field of liquid chromatographs, in particular to a liquid chromatograph which is easy to operate. Background Art

[0002] High performance liquid chromatography can separate and analyze various compounds, such as drugs, natural products, food additives, environmental pollutants, etc. It provides powerful tools and technical support for scientific research and quality control, and is widely used in pharmaceutical, food safety, environmental monitoring, biomedicine, chemical analysis and other fields. The structure of high performance liquid chromatography usually consists of several parts such as liquid reservoir, pump, injector, chromatographic column, detector, recorder, etc. Among them, the liquid reservoir is usually a solvent bottle for storing mobile phase solvent. The mobile phase in the liquid reservoir is pumped into the detection system by a high pressure pump, and the sample solution enters the mobile phase through the injector and is loaded into the chromatographic column by the mobile phase, thereby achieving separation and analysis of sample components.

[0003] A patent of Chinese patent application CN207882222U discloses a high performance liquid chromatograph, the technical scheme of which is as follows: it includes a drug placement tank, a solvent medicine bottle is arranged at the top of the drug placement tank, a detector is arranged at the lower end of the drug placement tank, the detector includes a high pressure pump, the high pressure pump is connected to the controller, the lower end of the controller is connected to a number of mobile compatibilizer beakers through a shunt interface, the two ends of the shunt interface are respectively provided with control screws, the controller is provided with tightening screws, the controller is connected to the drug inlet tank, a drug inlet port is arranged on one side of the drug inlet tank, the lower end of the drug inlet tank is respectively connected to a liquid beaker and a liquid test tube, the drug inlet tank is connected to a chromatographic column through a pressure gauge, the chromatographic column is connected to a display through an analysis unit, and the display is connected to a waste liquid beaker through an analysis unit. This technology can conduct further in-depth analysis after the analysis of the drug, saves manpower, reduces costs, brings convenience to pharmaceutical manufacturers, has a reasonable design, and improves practicality.

[0004] However, the above technology often has the following defects: when using an existing high-performance liquid chromatograph, the solvent bottle is usually placed directly on the top of the chromatograph, and then connected to the delivery pump with a catheter. Not only is the stability low and easy to overturn and tip over, but the solvent bottle is usually packaged in small capacity and needs to be replaced when the solvent inside is used up. The operation is cumbersome and inconvenient to use. Especially when facing large-scale analysis work, the solvent bottle needs to be replaced frequently and the catheter needs to be reconnected, which seriously reduces the working efficiency of the liquid chromatograph.

[0005] To this end, the present invention provides a liquid chromatograph that is easy to operate. Summary of the invention

[0006] In order to make up for the deficiencies of the prior art, at least one technical problem raised in the background technology is solved.

[0007] The technical solution adopted by the present invention to solve the technical problem is as follows: the liquid chromatograph which is easy to operate in the present invention comprises a chromatograph body, a supporting component and a liquid storage component; The supporting assembly is provided with a group and is fixedly connected to the upper side of the chromatograph body; the supporting assembly includes a base; a support tube is fixedly connected to the upper side of the base; a trumpet-shaped bracket is fixedly connected to the top of the support tube; The liquid storage component is provided in a group and is placed on the upper side of the supporting component respectively; the liquid storage component includes a reagent bottle; the top of the reagent bottle is provided with a liquid inlet, and the bottom of the reagent bottle is provided with a liquid outlet; the liquid inlet is internally threadedly connected with a blocking block; the upper side of the blocking block is fixedly connected with a twist plate.

[0008] Preferably, a mounting plate is fixedly connected inside the support tube; a connecting sleeve is fixedly connected to the upper side of the mounting plate; the liquid outlet bottle mouth is threadedly connected to the inside of the connecting sleeve; a liquid outlet pipe is connected to the bottom of the connecting sleeve, and the liquid outlet pipe passes through the mounting plate; the liquid outlet pipe is connected to the delivery pump inside the chromatograph body.

[0009] Preferably, a sealing gasket is provided between the bottom of the liquid outlet bottle and the mounting plate.

[0010] Preferably, a trumpet-shaped liquid adding funnel is fixedly connected to the top of the liquid inlet bottle.

[0011] Preferably, a water supply pipe and a drainage pipe are provided on one side of the chromatograph body; a water inlet is provided on the top of the reagent bottle; a water supply branch pipe is connected between the water inlet and the water supply pipe; a drainage branch pipe is connected between the bottom of the connecting sleeve and the drainage pipe, and the drainage branch pipe passes through the mounting plate; valve bodies are provided on both the water supply pipe and the drainage pipe.

[0012] Preferably, the reagent bottle is designed to be cylindrical; the water inlet is tangent to the top of the reagent bottle.

[0013] Preferably, a support is fixedly connected to the top of the reagent bottle via a connecting rod; a rotating wheel is rotatably connected to the lower side of the support; a group of blades are evenly distributed on the circumference of the rotating wheel surface, and the blades are at the same height as the water inlet; a brush strip is fixedly connected to the end of the blade; and the brush strip fits against the inner wall of the reagent bottle.

[0014] Preferably, a boss is fixedly connected to the outer wall surface of the reagent bottle; and a label plate is provided on the surface of the boss.

[0015] Preferably, the top and bottom of the boss are both provided with a slide groove; a scraper is slidably connected inside the slide groove; the inner side of the scraper and the label plate are in contact with each other, and a shift block is fixedly connected to the outer side of the scraper.

[0016] Preferably, the boss and the blade are at the same height; a connecting plate is fixedly connected to one side of the boss; an elastic member is fixedly connected between the scraper and the connecting plate; the blade or the shift block is magnetic, and the blade and the shift block attract each other when they are close to each other.

[0017] The beneficial effects of the present invention are as follows: 1. The present invention discloses an easy-to-operate liquid chromatograph, which supports the reagent bottle by arranging a supporting assembly, and utilizes the cooperation between the support tube and the bracket to improve the stability of the reagent bottle when placed. The reagent bottle is reusable and is used to store mobile phase solvent. When the solvent inside the reagent bottle is used up, the sealing block can be screwed out upward by a twist plate, so that the liquid inlet bottle mouth is in an open state, and then the mobile phase solvent can be added to the inside of the reagent bottle through the liquid inlet bottle mouth, thereby eliminating the need to remove and replace the reagent bottle, greatly simplifying the solvent addition steps, and the operation process is more convenient.

[0018] 2. The easy-to-operate liquid chromatograph described in the present invention, during the initial installation, the bottom of the reagent bottle is placed inside the bracket and the bracket, the reagent bottle is twisted and the liquid outlet bottle mouth is screwed into the connecting sleeve to further fix the reagent bottle to prevent it from tipping over during use, and after being screwed in, the liquid outlet pipe is automatically connected to the liquid outlet bottle mouth, and there is no need to manually perform complicated catheter connection work, which further improves the convenience of operation of the chromatograph, and then the liquid inlet bottle mouth is opened and the solvent is added. In subsequent use, the mobile phase solvent in the reagent bottle can be input into the chromatograph body through the liquid outlet pipe by using the delivery pump inside the chromatograph body, thereby realizing separation and analysis of sample components. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The present invention will be further described below in conjunction with the accompanying drawings.

[0020] Figure 1 is a stereogram of the present invention; Figure 2 It is a schematic diagram of the structure of the supporting component and the liquid storage component in the present invention; Figure 3 yes Figure 2 A partial enlarged view of the middle part; Figure 4 yes Figure 2 A partial enlarged view of point B in the middle; Figure 5 yes Figure 2 A partial enlarged view of point C in the middle; Figure 6 It is a schematic diagram of the structure of the blades and brush strips in the present invention.

[0021] In the figure: chromatograph body 1, supporting assembly 2, liquid storage assembly 3, base 4, bracket 5, bracket 6, reagent bottle 7, liquid inlet bottle mouth 8, liquid outlet bottle mouth 9, blocking block 10, twist plate 11, mounting plate 12, connecting sleeve 13, liquid outlet pipe 14, sealing gasket 15, liquid adding bucket 16, water supply main pipe 17, drainage main pipe 18, water inlet 19, water supply branch pipe 20, drainage branch pipe 21, connecting rod 22, support 23, runner 24, blade 25, brush strip 26, boss 27, label plate 28, slide 29, scraper 30, shift block 31, connecting plate 32, elastic member 33. DETAILED DESCRIPTION

[0022] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0023] like Figures 1 to 6 As shown, the liquid chromatograph which is easy to operate according to the present invention comprises a chromatograph body 1, a supporting component 2 and a liquid storage component 3; The support assembly 2 is provided with a group and is fixedly connected to the upper side of the chromatograph body 1; the support assembly 2 includes a base 4; a support tube 5 is fixedly connected to the upper side of the base 4; a trumpet-shaped bracket 6 is fixedly connected to the top of the support tube 5; The liquid storage component 3 is provided with a group and is placed on the upper side of the supporting component 2 respectively; the liquid storage component 3 includes a reagent bottle 7; a liquid inlet port 8 is provided on the top of the reagent bottle 7, and a liquid outlet port 9 is provided on the bottom of the reagent bottle 7; the liquid inlet port 8 is internally threadedly connected to a blocking block 10, the inner side of the liquid inlet port 8 is provided with an internal thread, and the outer side of the blocking block 10 is provided with an external thread; a twist plate 11 is fixedly connected to the upper side of the blocking block 10.

[0024] When using a liquid chromatograph in the prior art, a solvent bottle is usually placed directly on the top of the chromatograph, and then connected to a delivery pump with a conduit. Not only is the stability low and easy to tip over, but the solvent bottle is usually packaged in small volumes and needs to be replaced when the solvent inside is used up. The operation is cumbersome and inconvenient to use. Especially when facing large-scale analysis work, the solvent bottle needs to be replaced frequently and the conduit needs to be reconnected, which seriously reduces the working efficiency of the liquid chromatograph.

[0025] The present invention supports the reagent bottle 7 by providing a supporting component 2, and utilizes the support tube 5 and the bracket 6 to cooperate with each other to improve the stability of the reagent bottle 7 when it is placed. The reagent bottle 7 is reusable and is used to store mobile phase solvent. When the solvent inside the reagent bottle 7 is used up, the blocking block 10 can be screwed out upwards through the twist plate 11, so that the liquid inlet bottle mouth 8 is in an open state, and then the mobile phase solvent can be added to the inside of the reagent bottle 7 through the liquid inlet bottle mouth 8, so there is no need to remove and replace the reagent bottle 7, which greatly simplifies the solvent adding steps and the operation process is more convenient. In addition, in order to facilitate the observation of the liquid level position, the reagent bottle 7 should be made of a transparent material or an observation window should be provided on its surface.

[0026] The inside of the bracket 5 is fixedly connected with a mounting plate 12; the upper side of the mounting plate 12 is fixedly connected with a connecting sleeve 13; the liquid outlet bottle mouth 9 is threadedly connected to the inside of the connecting sleeve 13, the inner side of the connecting sleeve 13 is provided with an internal thread, and the outer side of the liquid outlet bottle mouth 9 is provided with an external thread; the bottom of the connecting sleeve 13 is connected with a liquid outlet pipe 14, and the liquid outlet pipe 14 passes through the mounting plate 12; the liquid outlet pipe 14 is connected to the delivery pump inside the chromatograph body 1; during the initial installation, the bottom of the reagent bottle 7 is placed inside the bracket 6 and the bracket 5, the reagent bottle 7 is twisted and the liquid outlet bottle 9 is placed. The opening 9 is screwed into the connecting sleeve 13 to further fix the reagent bottle 7 to prevent it from tipping over during use, and after being screwed in, the liquid outlet pipe 14 is automatically connected to the liquid outlet bottle opening 9, without the need for manual complicated catheter connection work, further improving the convenience of operation of the chromatograph, and then the liquid inlet bottle opening 8 is opened and the solvent is added. In subsequent use, the delivery pump inside the chromatograph body 1 can be used to input the mobile phase solvent in the reagent bottle 7 into the chromatograph body 1 through the liquid outlet pipe 14, thereby realizing the separation and analysis of the sample components.

[0027] A sealing gasket 15 is provided between the bottom of the liquid outlet bottle opening 9 and the mounting plate 12; by providing the sealing gasket 15, the sealing gasket 15 is compressed when the liquid outlet bottle opening 9 is screwed into the connecting sleeve 13 to improve the sealing between the liquid outlet bottle opening 9 and the connecting sleeve 13 to prevent solvent leakage.

[0028] A trumpet-shaped liquid adding hopper 16 is fixedly connected to the top of the liquid inlet bottle opening 8; by providing the liquid adding hopper 16, it is convenient to add solvent into the liquid inlet bottle opening 8, and the solvent is prevented from spilling out during the adding process.

[0029] As a preferred embodiment of the present invention, a water supply pipe 17 and a drainage pipe 18 are provided on one side of the chromatograph body 1. The water supply pipe 17 can be connected to an external clean water source, such as a tap water pipeline, and the drainage pipe 18 can be connected to a waste liquid tank or a waste liquid treatment pool; a water inlet 19 is provided on the top of the reagent bottle 7; a water supply branch pipe 20 is connected between the water inlet 19 and the water supply pipe 17; a drainage branch pipe 21 is connected between the bottom of the connecting sleeve 13 and the drainage pipe 18, and the drainage branch pipe 21 passes through the mounting plate 12; valve bodies are provided on the water supply pipe 17 and the drainage pipe 18; when the reagent bottle 7 is used for a long time, , a layer of dirt may adhere to the inner wall surface, or when other types of solvents need to be replaced, the inside of the reagent bottle 7 needs to be cleaned. By opening the valve bodies of the water supply main pipe 17 and the drainage main pipe 18, clean water flows along the water supply main pipe 17 into the multiple water supply branch pipes 20, and then flows into the multiple reagent bottles 7 through the water inlet 19 to rinse the reagent bottles 7 to remove dirt or prevent different types of solvents from affecting each other's purity. There is no need to disassemble the reagent bottle 7 and clean it manually, which further improves the working efficiency of the chromatograph. The cleaned sewage flows along the liquid outlet bottle 9 and the drainage branch pipe 21 into the drainage main pipe 18 and flows to the discharge point.

[0030] The reagent bottle 7 is designed to be cylindrical; the water inlet 19 is tangent to the top of the reagent bottle 7; when clean water enters the reagent bottle 7 through the water inlet 19, a spiral downward water flow can be formed at the inner wall of the reagent bottle 7, thereby making the flushing effect on the inner wall of the reagent bottle 7 more uniform, so as to fully remove the dirt or residual solvent inside the reagent bottle 7.

[0031] As a preferred embodiment of the present invention, a support 23 is fixedly connected to the top of the reagent bottle 7 through a connecting rod 22; a rotating wheel 24 is rotatably connected to the lower side of the support 23; a group of blades 25 are evenly distributed on the circumference of the surface of the rotating wheel 24, and the blades 25 are at the same height as the water inlet 19; a brush strip 26 is fixedly connected to the end of the blade 25; the brush strip 26 and the inner wall of the reagent bottle 7 are in contact with each other; when water flows into the reagent bottle 7 through the water inlet 19, it will impact the surface of the blade 25, driving the rotating wheel 24 and multiple blades 25 to move Rotates, so part of the water flow forms a spiral vortex at the inner wall of the reagent bottle 7, and the other part of the water collides with the blades 25 and breaks, rebounds, and splashes, forming a large number of water droplets with different directions inside the reagent bottle 7, thereby flushing the reagent bottle 7 in all directions and at different angles, especially for the top inner wall of the reagent bottle 7, and the blade 25 can drive the brush bar 26 to rotate together, causing the brush bar 26 to rub on the inner wall surface of the reagent bottle 7, further scraping off the stubborn residue, and improving the cleaning efficiency of the reagent bottle 7.

[0032] As a preferred embodiment of the present invention, a boss 27 is fixedly connected to the outer wall surface of the reagent bottle 7; a label plate 28 is provided on the surface of the boss 27, and the label plate 28 can be an electronic display screen, or a handwritten label paper that is then pasted on the surface of the label plate 28, or a handwritten label card that is then inserted into the interlayer of the label plate 28; by setting the label plate 28, data information such as the type, composition, concentration, and usage time of the solvent in the reagent bottle 7 can be set on the label plate 28, which is convenient for the staff to check in time.

[0033] The top and bottom of the boss 27 are both provided with a slide groove 29; a scraper 30 is slidably connected inside the slide groove 29; the inner side of the scraper 30 and the label plate 28 are in contact with each other, and a shift block 31 is fixedly connected to the outer side of the scraper 30; if there is water vapor, dust or other dirt on the label plate 28, the scraper 30 can be slid left and right to wipe off the dirt on the surface of the label plate 28 with the scraper 30 to keep it clean and prevent the dirt from blocking the information on the label plate 28.

[0034] In order to improve the wiping effect, a layer of flexible material, such as cotton cloth, rubber strip, sponge, etc., can be arranged inside the scraper 30 to enhance its decontamination ability and prevent the label plate 28 from being scratched.

[0035] The boss 27 is at the same height as the blade 25; a connecting plate 32 is fixedly connected to one side of the boss 27; an elastic member 33 is fixedly connected between the scraper 30 and the connecting plate 32, and the elastic member 33 can be a spring, an elastic rope, a rubber band, etc.; the blade 25 or the shift block 31 is magnetic, and the blade 25 and the shift block 31 attract each other when they are close to each other; during the rotation of the blade 25, when the blade 25 rotates to a position close to the boss 27, the magnetic attraction can be used to attract the shift block 31 and drive the scraper 30 to move together, so that the scraper 30 slides in the direction away from the connecting plate 32 inside the slide groove 29, and when the blade 25 is away from the boss 27, the elastic member 33 pulls the scraper 30 to slide and reset, and multiple blades 25 intermittently pass over the boss 27, thereby driving the scraper 30 to continuously reciprocate left and right and wipe the surface of the label plate 28, so that in the process of cleaning the inside of the reagent bottle 7, the label plate 28 can also be automatically cleaned, further improving the cleaning efficiency of the device.

[0036] The above-mentioned front, back, left, right, top and bottom are all based on the figures in the specification. Figure 1 As a benchmark, according to the person's observation perspective, the side of the device facing the observer is defined as the front, the left side of the observer is defined as the left, and so on.

[0037] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the scope of protection of the present invention.

[0038] The above shows and describes the basic principles, main features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A liquid chromatograph that is easy to operate, characterized in that: It comprises a chromatograph body (1), a supporting component (2) and a liquid storage component (3); The support assembly (2) is provided with a group and is fixedly connected to the upper side of the chromatograph body (1); the support assembly (2) comprises a base (4); a support tube (5) is fixedly connected to the upper side of the base (4); a trumpet-shaped bracket (6) is fixedly connected to the top of the support tube (5); The liquid storage assembly (3) is provided with a group and is respectively placed on the upper side of the supporting assembly (2); the liquid storage assembly (3) comprises a reagent bottle (7); the top of the reagent bottle (7) is provided with a liquid inlet (8), and the bottom of the reagent bottle (7) is provided with a liquid outlet (9); the liquid inlet (8) is internally threadedly connected to a blocking block (10); the upper side of the blocking block (10) is fixedly connected to a twisting plate (11).

2. A liquid chromatograph that is easy to operate according to claim 1, characterized in that: The interior of the support tube (5) is fixedly connected to a mounting plate (12); the upper side of the mounting plate (12) is fixedly connected to a connecting sleeve (13); the liquid outlet bottle mouth (9) is threadedly connected to the interior of the connecting sleeve (13); the bottom of the connecting sleeve (13) is connected to a liquid outlet pipe (14), and the liquid outlet pipe (14) passes through the mounting plate (12); the liquid outlet pipe (14) is connected to a delivery pump inside the chromatograph body (1).

3. A liquid chromatograph that is easy to operate according to claim 2, characterized in that: A sealing gasket (15) is provided between the bottom of the liquid outlet bottle opening (9) and the mounting plate (12).

4. The liquid chromatograph that is easy to operate according to claim 1, characterized in that: A trumpet-shaped liquid adding hopper (16) is fixedly connected to the top of the liquid inlet bottle opening (8).

5. The liquid chromatograph that is easy to operate according to claim 1, characterized in that: A water supply pipe (17) and a drainage pipe (18) are provided on one side of the chromatograph body (1); a water inlet (19) is provided on the top of the reagent bottle (7); a water supply branch pipe (20) is connected between the water inlet (19) and the water supply pipe (17); a drainage branch pipe (21) is connected between the bottom of the connecting sleeve (13) and the drainage pipe (18), and the drainage branch pipe (21) passes through the mounting plate (12); valve bodies are provided on both the water supply pipe (17) and the drainage pipe (18).

6. A liquid chromatograph that is easy to operate according to claim 5, characterized in that: The reagent bottle (7) is designed to be cylindrical; the water inlet (19) is tangent to the top of the reagent bottle (7).

7. A liquid chromatograph that is easy to operate according to claim 6, characterized in that: A support (23) is fixedly connected to the top of the reagent bottle (7) via a connecting rod (22); a rotating wheel (24) is rotatably connected to the lower side of the support (23); a group of blades (25) are evenly distributed on the circumference of the surface of the rotating wheel (24), and the blades (25) are at the same height as the water inlet (19); a brush strip (26) is fixedly connected to the end of the blade (25); the brush strip (26) and the inner wall of the reagent bottle (7) are in contact with each other.

8. The liquid chromatograph easy to operate according to claim 7, characterized in that: A boss (27) is fixedly connected to the outer wall surface of the reagent bottle (7); and a label plate (28) is provided on the surface of the boss (27).

9. A liquid chromatograph that is easy to operate according to claim 8, characterized in that: The top and bottom of the boss (27) are both provided with a slide groove (29); a scraper (30) is slidably connected inside the slide groove (29); the inner side of the scraper (30) and the label plate (28) are in contact with each other, and a shifting block (31) is fixedly connected to the outer side of the scraper (30).

10. The liquid chromatograph easy to operate according to claim 9, characterized in that: The boss (27) and the blade (25) are at the same height; a connecting plate (32) is fixedly connected to one side of the boss (27); an elastic member (33) is fixedly connected between the scraper (30) and the connecting plate (32); the blade (25) or the shifting block (31) is magnetic, and the blade (25) and the shifting block (31) attract each other when they are close to each other.

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