Beast repelling liquid and application thereof

Abstract

The invention discloses beast repelling liquid and application thereof, and belongs to the technical field of security and protection. The beast expelling liquid comprises the following components: a thermal pain agonist, a cold pain agonist, a polar solvent, a non-polar solvent, a thickening adhesive and a surfactant, the expelling liquid disclosed by the invention can generate strong burning and pricking feelings after being inhaled or contacted with the skin for 5-10 seconds, so that the aims of expelling beast and protecting the safety of the beast are fulfilled. The repelling liquid is particularly suitable for being used by related workers in field grazing, construction, hiking, exploration, scientific investigation and the like to protect themselves from being attacked by wild animals.

Description

Technical Field

[0001] The invention relates to the technical field of security, and in particular to a wild animal repellent liquid and application thereof. Background Art

[0002] As humans develop the ability to improve their habitats (for example, the rise of agriculture and industry), they have had a profound impact on wildlife. Human-animal conflict arises when humans or wild animals cause adverse effects or harm to each other due to competition for space or natural resources. The most common cases are wild animals stealing and destroying farmers' crops, preying on herders' livestock, destroying houses and infrastructure, and even attacking humans, causing personal injury or death. In particular, in recent years, outdoor tourism has become a travel method that more and more people yearn for, and travelers are often attacked by wild animals in the wild. Because people often face economic losses or even personal injuries caused by wild animals, they may be hostile to wild animals to a certain extent, and then capture, poison or even kill wild animals in retaliation, affecting the smooth development of nature conservation work. Therefore, the problem of human-animal conflict is one of the most common and difficult problems faced by biological conservationists. Human-animal conflict is a global problem and has become an important problem that conservation biologists around the world urgently need to solve.

[0003] Among cats, dogs, bears and hyenas, some species are more likely to come into conflict with humans. The larger the carnivore and the closer it is to human settlements, the more likely it is to conflict. For example, in Sanjiangyuan, human-animal conflicts are specifically manifested in snow leopards, brown bears, wolves and other animals harming livestock, humans and destroying houses. In Yunnan, wild elephants have broken into villages in many places. In the Qinling Mountains, wild boars frequently appear in the mountains, not only destroying the crops that farmers have worked hard to grow, but also injuring people and livestock from time to time. Developing safe and efficient repellents for wild animals is an effective way to prevent and control hazards.

[0004] Tear gas spray originated in Canada. In order to reduce the harm of dogs to postmen, the Canadian postal department specially equipped postmen with anti-dog tear gas spray, which was then gradually used by various countries. Historically, there are three types of tear gas: xylene bromide, 2-chloroacetophenone and o-chlorobenzylidene malononitrile, but their use is restricted due to their high toxicity. In addition, some other preparations have also been widely used in recent years, such as pure natural capsicum oleoresin (OC for short), which has the advantages of low toxicity, weak sensory stimulation reaction and low harm. OC was first isolated from pepper in 1876 and can only be effective when it comes into direct contact with the skin and mucous membranes (eyes, nose, and mouth). If the skin is stained with it, a burning sensation will appear immediately; if the eyes touch it, it will burn, tear, swell, and temporarily impair vision; after inhalation through the mouth and nose, it will cause swelling of the mucous membrane on the surface of the respiratory tract, causing coughing and temporary breathing difficulties. When the liquid is sprayed on the face, it strongly stimulates the peripheral sensory system, causing severe facial pain, tearing, involuntary eye closure, and loss of resistance.

[0005] Transient receptor potential (TRP) proteins are non-selective cation channel proteins found in recent years to exist on cell membranes or intracellular organelle membranes. It is now clear that the proteins they encode are widely distributed in mammals, including humans. The functions they participate in mainly include temperature and pain sensation, mechanical sensation, taste, mediating phospholipase C-dependent calcium influx, and maintaining the ion state of cells. As an important cell receptor, TRP transmits information inside and outside the cell, and is also regulated by receptors, ligands, temperature changes, osmotic pressure and voltage-dependent changes from inside and outside the cell. The reason why OC can cause sensory stimulation to people or animals that come into contact with it is that capsaicin is an agonist of transient receptor potential vanilloid subtype 1 (TRPV1) protein. Under natural conditions, this protein receptor will cause cells to respond to ambient temperatures greater than 43 degrees Celsius and tell the brain a "pain" signal, that is, a thermal pain signal. Similarly, this protein receptor, which exists in large quantities in the human skin, will also react in the same way after being stimulated by capsaicin, causing the senses to experience burning and tingling. In addition to being sensitive to capsaicin, TRPV1 can also be activated by Euphorbiaceae gum lipid toxins, piperine, noxious heat stimulation (>43°C), acid (pH<5.3), inflammatory mediators, changes in extracellular osmotic pressure, and intracellular redox state. In addition, there are cold pain receptors in the human sensory organs. The receptor potential cation channel subfamily M member 8 (TRPM8) protein is a cold-sensitive receptor that is activated by temperatures around 25°C. It is one of the cold-sensitive channels discovered so far. Similarly, the TRPM8 channel can be activated by external aids such as menthol, eucalyptol, spearmint and other coolants to produce cold and tingling sensations. Studies have shown that some cold and hot Chinese patent medicines can activate TRPM8 or TRPV1, and this stimulant effect is stronger under heat load or cold load. In addition, menthol can also activate the receptor potential cation channel subfamily V member 3 (TRPV3), which contributes to menthol-induced sensitization to warm stimuli, which can explain why eating peppers and mint together can make people feel more spicy.

[0006] In view of this, in order to invent an efficient wild animal repellent suitable for outdoor grazing, construction, hiking, exploration, scientific research and other related workers to protect themselves from wild animal attacks, while not harming wild animals, especially the state protected animals such as Siberian tigers, snow leopards, and brown bears, it is particularly important to screen high-efficiency and low-toxic natural substances and combinations. In addition, natural extracts or analog repellents need to be optimized and used in combination with the body structure and activity patterns of the wild animals themselves, such as thick skin and flesh, insensitive sensory nerves on the skin, being able to twist the body to shake off moisture attached to the hair, being extremely retaliatory and easy to counterattack, etc. These characteristics also require the repellent to be wind-resistant, easy to penetrate hair, and have strong adhesion. Summary of the invention

[0007] In order to solve the above problems, the present invention provides a wild animal repellent liquid and application thereof.

[0008] The present invention firstly provides a wild animal repellent liquid, which comprises the following components: a thermal pain agonist, a cold pain agonist, a polar solvent, a non-polar solvent, a thickening adhesive and a surfactant.

[0009] The above-mentioned wild animal repellent liquid is composed of a thermal pain agonist, a cold pain agonist, a polar solvent, a non-polar solvent, a thickening adhesive and a surfactant.

[0010] In the above-mentioned beast repellent liquid, the thermal pain agonist is a substance that can activate transient receptor potential vanilloid subtype 1 (TRPV1) protein; the thermal pain agonist is an electrophilic agonist or a non-electrophilic agonist; specifically, the electrophilic agonist is at least one of capsaicin, AITC, allicin, cinnamaldehyde, diallyl disulfide, chloroacetophenone and lidocaine; the non-electrophilic agonist is at least one of arachidonic acid, capsaicin structural analogs, cinnamon oil and mustard oil; more specifically, it can be capsaicin, the chemical name is trans-8-methyl-N-vanillyl-6-nonenamide, the chemical formula is C 18 H 27 NO3;

[0011] The cold pain agonist is a substance that can activate the receptor potential cation channel subfamily M member 8 (TRPM8) protein; specifically, the cold pain agonist is at least one of menthol, WS-3 (N-ethyl-p-menthyl-3-carboxamide), WS-23 (2-isopropyl-N,2,3-trimethylbutyramide) and menthone glycerol acetal; more specifically, it can be menthol, the chemical formula of which is C 10 H 20 O.

[0012] In the above-mentioned beast repelling liquid, the polar solvent is water;

[0013] The non-polar solvent is a solvent that can dissolve both the heat pain agonist and the cold pain agonist and is miscible with water. Specifically, the non-polar solvent is at least one of anhydrous ethanol, isopropanol, methylene glycol and dimethyl sulfoxide (DMSO).

[0014] In the above-mentioned beast repellent liquid, the thickening adhesive is at least one of glycerin, gelatin, sodium caseinate, gum arabic, tamarind polysaccharide gum, sesbania gum, agar, sodium alginate, sodium alginate, algin, carrageenan, pectin, xanthan gum, β-cyclodextrin, sodium carboxymethyl cellulose (CMC-Na), sodium starch phosphate (sodium starch phosphate), sodium carboxymethyl starch, hydroxypropyl starch and propylene glycol alginate (PGA); specifically, it can be glycerin;

[0015] The surfactant is at least one of sodium dodecyl sulfate, sodium stearate, potassium stearate, sodium oleate, sodium dodecyl sulfate, hexadecyl sulfated castor oil, fatty acid glycerides, sucrose fatty acid esters, fatty acid sorbitan, polysorbate, benzyl alcohol, benzyl alcohol and poloxamer; specifically, it can be sodium dodecyl sulfate.

[0016] In the above-mentioned beast repellent liquid, based on the total volume of the polar solvent, the non-polar solvent and the thickening adhesive, the volume percentage of the polar solvent is 30-45%; the volume percentage of the non-polar solvent is 45-50%; and the volume percentage of the thickening adhesive is 5-25%.

[0017] Specifically, based on the total volume of the polar solvent, the non-polar solvent and the thickening adhesive, the volume percentage of the polar solvent is 35%; the volume percentage of the non-polar solvent is 45%; and the volume percentage of the thickening adhesive is 20%;

[0018] Based on the total mass of the beast repelling liquid, the mass percentage of the thermal pain agonist is 2-5%; the mass percentage of the cold pain agonist is 1-4%; and the mass percentage of the surfactant is 2-5%.

[0019] Specifically, based on the total mass of the beast repelling liquid, the mass percentage of the thermal pain agonist is 3%; the mass percentage of the cold pain agonist is 1%; and the mass percentage of the surfactant is 2%.

[0020] The present invention further provides a method for preparing the above-mentioned beast repelling liquid, comprising the following steps: dissolving the thermal pain agonist and the cold pain agonist in a non-polar solvent, dissolving the surfactant in a polar solvent, and then mixing the two, adding a thickening adhesive, and mixing well to obtain the beast repelling liquid.

[0021] The use of the above-mentioned beast repelling liquid in repelling beasts also falls within the protection scope of the present invention.

[0022] The results of animal experiments show that, compared with the repelling liquid without adding a surfactant, the repelling liquid of the present invention is easier to penetrate the hair to contact the skin or directly adhere to the hair; compared with the repelling liquid without adding a thickening adhesive, the repelling liquid of the present invention is easier to adhere to the face, skin and hair of animals, and is not easy to be removed; compared with the repelling liquid with a single capsaicin formula, the repelling liquid with a combination of capsaicin + menthol produces a stronger burning and stinging sensation at the same concentration, or makes a low concentration of capsaicin + menthol produce a burning sensation of the same intensity.

[0023] The present invention has the following beneficial effects:

[0024] The present invention uses a combination of capsaicin + menthol to simultaneously activate heat pain receptors and cold pain receptors, i.e., TRPV1 and TRPM8. The activation of the two receptor proteins will not only not be interfered with by capsaicin and menthol, but will provide heat load and cold load at the same time after activating heat pain receptors and cold pain receptors respectively; under these two loads, TRPV1 and TRPM8 receptor protein expression and activation degree are higher, and individuals feel stronger burning pain, itching and tingling. Compared with the repellent of a single capsaicin formula, the repellent of the formula combination of capsaicin + menthol produces a stronger burning and tingling sensation at the same concentration, or makes a low concentration of capsaicin + menthol produce a burning sensation of equal intensity. This design can provide stronger sensory stimulation for beasts with thick skin or stronger resistance, and effectively repel. At the same time, this design can also be used under low concentrations of capsaicin, reducing the damage of capsaicin to beasts under the premise of ensuring high efficiency, especially for endangered wild animals.

[0025] The repellent liquid of the present invention is designed for wild animals. The surfactant and thickening adhesive assist the repellent to better eliminate the interference of grease on the animal fur, so that the repellent liquid can better penetrate the hair and contact the skin. At the same time, it is easier to adhere to the hair and skin, not easy to be removed, and exerts the sensory cold and hot stimulation effect for a longer time. The repellent liquid is thrown on the target animal with the help of a compressed air spray can, a high-pressure water gun, a spray pot, an electronic water spray gun, etc., and is used to repel large dogs, foxes, wolves, bears, jackals and other wild beasts. The repellent liquid is particularly suitable for use by relevant personnel in field grazing, construction, hiking, exploration, scientific research, etc. to protect themselves from wild beast attacks. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 The physical and chemical properties of high pressure sprinkler irrigation;

[0027] Figure 2 This is the measured effect diagram of high-pressure sprinkler irrigation;

[0028] Figure 3 This is the actual picture after the trigger sprinkler irrigation is installed;

[0029] Figure 4 This is the measured effect diagram of trigger sprinkler irrigation.

[0030] Figure 5 This is a diagram showing the measured effect of trigger sprinkler irrigation on the return of brown bears. DETAILED DESCRIPTION

[0031] The present invention is further described in detail below in conjunction with specific embodiments. The given examples are only for illustrating the present invention, rather than for limiting the scope of the present invention.

[0032] The experimental methods in the following examples are all conventional methods unless otherwise specified.

[0033] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0034] The ethanol used in the following examples is anhydrous ethanol.

[0035] The Brandt's voles used in the following examples were 3-month-old adult mice with an average body length of 12 cm, an average weight of 31 g, and a fur length of 6-8 mm. They were captured in the wild and bred in the laboratory.

[0036] Example 1

[0037] Group A reagents: non-polar solvent ethanol (45% volume fraction) + polar solvent water (35% volume fraction) + thickening adhesive glycerol (20% volume fraction); the preparation method is as follows: taking the preparation of 1000mL Group A reagents as an example, measure 450mL of anhydrous ethanol and 200mL of glycerol into a 1000mL volumetric flask, and add water to make up to 1000mL.

[0038] Group B reagents: non-polar solvent ethanol (45% volume fraction) + polar solvent water (35% volume fraction) + thickening adhesive glycerol (20% volume fraction) + surfactant sodium dodecyl sulfate (2% mass fraction); the preparation method is as follows: taking the preparation of 1000mL of Group B reagents as an example, measure 450mL of anhydrous ethanol and 200mL of glycerol and place them in a 1000mL volumetric flask, weigh 20g of sodium dodecyl sulfate and dissolve it in 350mL of water, then place all the aqueous solutions in a 1000mL volumetric flask and add water to 1000mL.

[0039] The mass percentage of sodium dodecyl sulfate refers to its percentage of the total mass of group B reagents.

[0040] Reagents in group A and group B were separately canned in manual spray bottles, and sprayed on the back and head of the experimental Brandt's vole 5-8 times to ensure that the spraying amount of reagents in group A and group B was consistent. Photos were taken to record the wetting effect of each group of reagents on the fur and skin of the Brandt's vole, and a balance was used to weigh the weight change of the Brandt's vole before and after spraying to calculate the weight of each group of reagents remaining on the body surface of the mouse.

[0041] Brandt's voles have dense hair and oil on it. Under natural conditions, water vapor and water droplets will be blocked by the hydrophobic hair, so they cannot wet the hair and skin. The photos and video records taken during the experiment showed that after spraying the A group reagent and the B group reagent, the A group reagent did not contain a surfactant. After spraying the hair on the back of the Brandt's voles, most of the water vapor gathered into water droplets, and then flowed along the hydrophobic hair. The water vapor wetted the hair and then contacted the skin due to the hydrophobic effect of ethanol and glycerol. The weight change of the Brandt's voles was weighed before and 1 minute after spraying, and the weight of the reagent retained in their hair was calculated. The average weight gain of the Brandt's voles in group A was 0.15g. Since the B group reagent contains a surfactant, most of the water vapor will wet the hair and skin due to the lipophilic effect. The weight changes of Brandt's voles in Group B were weighed before and 1 minute after spraying, and the weight of the reagent retained in their hair was calculated. The average weight gain was 0.42 g, which was significantly different from the weight gain of Brandt's voles after the reagent in Group A acted on them (Table 1).

[0042] Table 1 Statistics of weight changes of Brandt's voles before and after the action of group A and group B reagents

[0043] Mouse number 1 2 3 4 5 6 7 8 9 10 average Group A (g) 0.15 0.14 0.12 0.17 0.08 0.15 0.13 0.10 0.18 0.16 0.153 Group B (g) 0.42 0.45 0.46 0.5 0.32 0.40 0.60 0.28 0.30 0.47 0.42

[0044] Example 2

[0045] In the embodiment, two sets of drive-off liquid base liquids are configured as follows:

[0046] Group A reagents: non-polar solvent ethanol (45% volume fraction) + polar solvent water (55% volume fraction) + surfactant sodium dodecyl sulfate (2% mass fraction); the preparation method is as follows: taking the preparation of 1000mL Group A reagents as an example, measure 450mL of anhydrous ethanol and place it in a 1000mL volumetric flask, weigh 20g of sodium dodecyl sulfate and dissolve it in 550mL of water, then place all the aqueous solutions in a 1000mL volumetric flask, and add water to 1000mL.

[0047] Group B reagents: non-polar solvent ethanol (45% volume fraction) + polar solvent water (35% volume fraction) + thickening adhesive glycerol (20% volume fraction) + surfactant sodium dodecyl sulfate (2% mass fraction); the preparation method is as follows: taking the preparation of 1000mL of Group B reagents as an example, measure 450mL of anhydrous ethanol and 200mL of glycerol and place them in a 1000mL volumetric flask, weigh 20g of sodium dodecyl sulfate and dissolve it in 350mL of water, then place all the aqueous solutions in a 1000mL volumetric flask and add water to 1000mL.

[0048] The mass percentage of sodium dodecyl sulfate refers to its percentage of the total mass of the prepared reagents.

[0049] Reagents of group A and group B were canned in manual spray bottles respectively, and sprayed on the back and head of the experimental Brandt's vole 5-8 times to ensure that the spraying amount of reagents of group A and group B was consistent. Photos were taken after 5 minutes and 30 minutes to record the wetting of the fur and skin of Brandt's vole by each group of reagents, and the weight changes of Brandt's vole before spraying and 5 minutes and 30 minutes after spraying were weighed using a balance to calculate the weight of each group of reagents remaining on the body surface of Brandt's vole.

[0050] The photographs and video records show the adhesion effect after spraying the reagents in Group A and Group B. When the animal's body surface is stained with water and other debris, they generally shake their hair or use their claws to remove foreign matter. Similarly, when the reagents in Group A and Group B are sprayed on the back of Brandt's voles, the Brandt's voles will shake and dry their hair. Since the reagent in Group A does not contain a thickening adhesive, after spraying the hair on the back of the Brandt's voles, the Brandt's voles will then shake and dry their bodies. After 5 minutes, the bodies are basically dried. After 30 minutes, as the hair is dried and the liquid evaporates, the weight of the Brandt's voles is the same as before spraying the reagents. However, since the reagent in Group B contains a thickening adhesive, the adhesive adheres to the hair and skin. Although the Brandt's voles immediately begin to dry their hair after spraying, a large amount of liquid is still adhered to the fur after 5 minutes. After 30 minutes, it can still be seen that there is obvious liquid residue on the fur, which has not been completely removed. The amount of residual liquid was calculated by weighing the body weight change before and after spraying. The reagent in group A had 0.13 g residual after 5 minutes and 0 g residual after 30 minutes, while the reagent in group B had 0.3 g residual after 5 minutes and 0.2 g residual after 30 minutes (Table 2).

[0051] Table 2 Statistics of body weight changes of Brandt's voles before and after the action of group A and group B reagents

[0052]

[0053] Example 3

[0054] In this embodiment, two sets of drive-off liquid base liquids are configured as follows:

[0055] Group A reagents: non-polar solvent ethanol (45% volume fraction) + polar solvent water (55% volume fraction) + surfactant sodium dodecyl sulfate (2% mass fraction) + thermal pain agonist capsaicin (0.5% mass fraction) + cold pain agonist menthol (0.3% mass fraction); the preparation method is as follows: taking the preparation of 1000mL Group A reagents as an example, weigh 5g capsaicin and 3g menthol, dissolve them in 450mL anhydrous ethanol and place them in a 1000mL volumetric flask, weigh 20g sodium dodecyl sulfate and dissolve it in 500mL water, then place all the aqueous solutions in a 1000mL volumetric flask, and add water to 1000mL.

[0056] Group B reagents: non-polar solvent ethanol (45% volume fraction) + polar solvent water (55% volume fraction) + surfactant sodium dodecyl sulfate (2% mass fraction) + thermal pain agonist capsaicin (1% mass fraction);

[0057] The preparation method is as follows: taking the preparation of 1000mL of group B reagent as an example, weigh 10g of capsaicin, dissolve it in 450mL of anhydrous ethanol and place it in a 1000mL volumetric flask, weigh 20g of sodium dodecyl sulfate and dissolve it in 500mL of water, then place all the aqueous solutions in a 1000mL volumetric flask and add water to 1000mL.

[0058] Group C reagents: non-polar solvent ethanol (45% volume fraction) + polar solvent water (55% volume fraction) + surfactant sodium dodecyl sulfate (2% mass fraction) + thermal pain agonist capsaicin (0.5% mass fraction); the preparation method is as follows: taking the preparation of 1000mL Group C reagents as an example, weigh 5g of capsaicin, dissolve it in 450mL of anhydrous ethanol and place it in a 1000mL volumetric flask, weigh 20g of sodium dodecyl sulfate and dissolve it in 500mL of water, then place all the aqueous solutions in a 1000mL volumetric flask, and add water to 1000mL.

[0059] The mass percentages of sodium dodecyl sulfate, capsaicin and menthol all refer to their percentages in the total mass of the prepared reagents.

[0060] The reagents of groups A, B and C were respectively canned in manual spray bottles and evenly applied to the back of Brandt's voles, whose back hair had been removed in advance, in the shape of 2*2cm 2 Then, photos were taken to record the sensory stimulation of each group of reagents on Brandt's voles and their abnormal reactions. The scratching frequency of Brandt's voles and the time when redness and swelling appeared and subsided were counted.

[0061] The abnormal reactions of Brandt's voles were recorded by taking photos. It was shown that after the A-group reagent (containing 0.5% mass fraction of capsaicin + 0.3% menthol) acted on the skin of Brandt's voles, 3-5 seconds later, the Brandt's voles quickly developed scratching and discomfort, but the skin was slightly red and swollen; after the B-group reagent (containing 1% mass fraction of capsaicin) acted on the skin of Brandt's voles, 3-5 seconds later, the Brandt's voles quickly developed scratching and discomfort, and the skin was obviously red and swollen; after the repellent of the C-group reagent (containing 0.5% mass fraction of capsaicin) acted on the skin of Brandt's voles, the Brandt's voles had a slight discomfort and the skin was slightly red and swollen.

[0062] Table 3 is the statistics of the scratching frequency of Brandt's voles at different time points after being smeared with reagents in groups A, B, and C. Compared with Brandt's voles treated with reagents in groups A and B, the scratching frequency of the two groups of Brandt's voles was consistent within 0-5 minutes after being smeared with the reagents. After 5 minutes, as time went on, the thermal pain receptors of Brandt's voles treated with reagents in group A became desensitized, and the scratching frequency gradually decreased. For Brandt's voles treated with reagents in group B, the desensitization time of thermal pain receptor proteins was extended to 17 minutes later. Compared with Brandt's voles treated with reagents in groups A and C, Brandt's voles treated with reagents in group A had a higher frequency of scratching within 0-5 minutes after being smeared with the reagents. As the thermal pain receptors became desensitized, the scratching frequencies of the two groups tended to be consistent after 5 minutes.

[0063] Table 4 shows the time when redness and swelling appeared on the skin after applying the reagents in groups A, B, and C, and the time when the redness and swelling subsided. The Brandt's voles immediately developed redness and swelling after being treated with the reagents in groups A, B, and C. The Brandt's voles developed slight redness and swelling after being treated with the reagents in groups A and C, and the swelling gradually subsided after 20 minutes, while the redness and swelling gradually subsided after 40 minutes after being treated with the reagents in group B.

[0064] Table 3 Statistics of scratching frequency of Brandt's voles before and after the action of reagents in groups A, B and C

[0065]

[0066] Table 4 Statistics of the time for redness and swelling to subside before and after the action of reagents in groups A, B and C on Brandt's voles

[0067]

[0068] Example 5: The application of the repellent liquid in the spraying device can effectively repel Tibetan brown bears

[0069] 1. The composition of the drive-out liquid is as follows:

[0070] Non-polar solvent ethanol (45% volume fraction) + polar solvent water (35% volume fraction) + adhesive glycerol (20% volume fraction) + surfactant sodium dodecyl sulfate (2% mass fraction) + thermal pain agonist capsaicin (3% mass fraction) + cold pain agonist menthol (1% mass fraction).

[0071] The mass percentages of sodium lauryl sulfate, capsaicin and menthol all refer to their percentages in the total mass of the repelling solution.

[0072] 2. The preparation method of the drive-out liquid is as follows:

[0073] Taking the preparation of 1000mL of expelling liquid as an example, weigh 30g of capsaicin and 10g of menthol, dissolve them in 450mL of anhydrous ethanol and place them in a 1000mL volumetric flask, weigh 20g of sodium dodecyl sulfate and dissolve it in 300mL of water and place all the aqueous solutions in a 1000mL volumetric flask, add 200mL of glycerol to the volumetric flask and add water to 1000mL.

[0074] 3. The compressed air can spray and high-pressure water gun spray were prepared to verify the repellent effect on brown bears in the wild. It was confirmed that (1) the repellent liquid has good solubility and uniformity, and is not easy to precipitate, agglomerate, or clog the nozzle. The effective spray distance of the compressed air can spray was 5-10m in the field, and the 470mL spray could be used continuously for 100-120s, with good wind resistance. The physical and chemical properties and measured effects of high-pressure sprinkler irrigation are shown in Figure 1 and Figure 2 (2) By preparing a trigger-type and remote-controlled high-pressure expellant spraying device, the actual installation diagram of the device is shown in Figure 3 Combined with real-time monitoring equipment, it is confirmed that the repellent and repellent equipment can effectively repel brown bears within 3-5 seconds, and the repellent rate is less than 20%. Figure 4 and Figure 5 .Depend on Figure 4 It can be seen that after the brown bear triggered the switch, it quickly fled, and had a brief period of rapid breathing and coughing, which subsided after a short time. Figure 5 It can be seen that when the brown bears that were driven away passed through the passage again, they hesitated and wandered around before returning. According to statistics, the return rate of the driven bears is less than 20%.

Claims

1. A wild animal repellent liquid, comprising the following components: a thermal pain agonist, a cold pain agonist, a polar solvent, a non-polar solvent, a thickening adhesive and a surfactant.

2. The animal repellent liquid according to claim 1, characterized in that: The thermal pain agonist is a substance that activates transient receptor potential vanilloid subtype 1 protein; The cold pain agonist is a substance that can activate the receptor potential cation channel subfamily M member 8 protein.

3. The animal repellent liquid according to claim 1, characterized in that: The thermal pain agonist is at least one of capsaicin, AITC, allicin, cinnamaldehyde, diallyl disulfide, chloroacetophenone, lidocaine, arachidonic acid, capsaicin structural analogs, cinnamon oil and mustard oil; The cold pain agonist is at least one of menthol, WS-3 (N-ethyl-p-menthyl-3-carboxamide), WS-23 (2-isopropyl-N,2,3-trimethylbutyramide) and menthone glycerol acetal.

4. The animal repellent liquid according to claim 3, characterized in that: The thermal pain agonist is capsaicin; The cold pain agonist is menthol.

5. The animal repellent liquid according to any one of claims 1 to 4, characterized in that: The polar solvent is water; The non-polar solvent is a solvent that can dissolve both the thermal pain agonist and the cold pain agonist and is miscible with water.

6. The animal repellent liquid according to claim 5, characterized in that: The non-polar solvent is at least one of anhydrous ethanol, isopropanol, methylene glycol and dimethyl sulfoxide.

7. The animal repellent liquid according to any one of claims 1 to 4, characterized in that: The thickening adhesive is at least one of glycerin, gelatin, sodium caseinate, gum arabic, tamarind polysaccharide gum, sesbania gum, agar, sodium alginate, sodium alginate, algin, carrageenan, pectin, xanthan gum, β-cyclodextrin, sodium carboxymethyl cellulose, sodium starch phosphate, sodium carboxymethyl starch, hydroxypropyl starch and propylene glycol alginate; The surfactant is at least one of sodium lauryl sulfate, sodium stearate, potassium stearate, sodium oleate, sodium lauryl sulfate, hexadecyl sulfated castor oil, fatty acid glyceride, sucrose fatty acid ester, fatty acid sorbitan, polysorbate, benzyl alcohol, benzyl alcohol and poloxamer.

8. The animal repellent liquid according to any one of claims 1 to 7, characterized in that: In the beast repellent liquid, based on the total volume of the polar solvent, the non-polar solvent and the thickening adhesive, the volume percentage of the polar solvent is 30-45%; the volume percentage of the non-polar solvent is 45-50%; and the volume percentage of the thickening adhesive is 5-25%. Based on the total mass of the beast repelling liquid, the mass percentage of the thermal pain agonist is 2-5%; the mass percentage of the cold pain agonist is 1-4%; and the mass percentage of the surfactant is 2-5%.

9. The method for preparing the animal repellent liquid as described in any one of claims 1 to 8 comprises the following steps: dissolving the thermal pain agonist and the cold pain agonist in a non-polar solvent, dissolving the surfactant in a polar solvent, and then mixing the two, adding a thickening adhesive, and mixing well to obtain the animal repellent liquid.

10. Use of the wild animal repellent liquid according to any one of claims 1 to 8 in repelling wild animals.

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