Laser detection and treatment integrated machine and laser output control method

Abstract

Embodiments of the present disclosure disclose a laser detection and treatment integrated machine and a laser output control method. A specific embodiment of the laser detection and treatment integrated machine comprises a Raman detection information acquisition device, a semiconductor laser output treatment device, and a touch screen processing device. The Raman detection information acquisition device comprises a Raman excitation light output device, an excitation light transmission optical fiber, a collimating mirror, a Raman pump light narrow band filter, a replaceable focusing mirror, a reflecting mirror, a Raman signal light transmission optical fiber, a first replaceable dichroic mirror, a second replaceable dichroic mirror, a third replaceable dichroic mirror, a first charge-coupled device camera, a second charge-coupled device camera, a third charge-coupled device camera, a host computer connection, and an analog-to-digital converter. The Raman detection information acquisition device is configured to acquire Raman spectrum data of a subject to be measured. The touch screen processing device is configured to perform a tissue abnormality detection and laser output step. The embodiment improves the laser treatment effect and reduces the operation treatment time.

Description

TECHNICAL FIELD

[0001] Embodiments of the present disclosure relate to the field of laser technology, in particular to a laser detection and treatment all-in-one machine and a laser output control method. BACKGROUND

[0002] With the aggravation of social aging and the change of lifestyle, the incidence of human tissue lesions or carcinogenesis (such as skin tumors, oral cancer) is gradually increasing worldwide. Laser output devices are applied to the treatment of various types of tissue lesions and carcinogenesis (such as skin tumors, oral cancer), which promotes the growth of market demand. At present, the existing laser output device for laser treatment is usually a traditional laser output device.

[0003] However, the above-mentioned traditional laser output device often has the following technical problems:

[0004] The function of the traditional laser output device is to destroy or excise the lesion and cancerous human tissue, and does not have the function of detecting abnormal human tissue (for example, lesion detection, cancer detection). When the traditional laser output device is used to excise abnormal tissue, the laser output device without detection function is limited to the emission of laser, and cannot detect the target tissue in real time or immediately, which increases the damage to normal tissue and the poor effect of laser treatment. In order to accurately and completely excise abnormal tissue, multiple abnormal detections of abnormal tissue are required, and in the case of using other detection devices (for example, X-ray tomography (CT) device) to detect abnormal tissue, more time is required to prepare the device, position the patient, and the detection operation steps are numerous, which increases the operation time.

[0005] The above information disclosed in this BACKGROUND section is only for the purpose of enhancing the understanding of the background of the present inventive concepts, and therefore, it can contain information that is not prior art known to those of ordinary skill in the art. SUMMARY

[0006] The summary of the present disclosure is intended to introduce the concepts in a simplified form, which will be described in detail in the specific embodiments section. The summary of the present disclosure is not intended to identify key or essential features of the claimed technical solutions, nor is it intended to limit the scope of the claimed technical solutions.

[0007] Some embodiments of the present disclosure propose a laser detection and treatment all-in-one machine and a laser output control method to solve one or more of the technical problems mentioned in the background section.

[0008] In a first aspect, some embodiments of the present disclosure provide a laser detection and treatment integrated machine, comprising: a Raman detection information acquisition device, a semiconductor laser output treatment device, a touch screen processing device; the Raman detection information acquisition device comprises a Raman excitation light output device, an excitation light transmission optical fiber, a collimating mirror, a Raman pump light narrow band filter, a replaceable focusing mirror, a reflecting mirror, a Raman signal light transmission optical fiber, a first replaceable dichroic mirror, a second replaceable dichroic mirror, a third replaceable dichroic mirror, a first charge coupled device camera, a second charge coupled device camera, a third charge coupled device camera, a host computer connection, and an analog-to-digital converter; the Raman excitation light output device is connected to the excitation light transmission optical fiber through a coaxial radio frequency connector; the Raman detection information acquisition device is used to collect Raman spectrum data of a to-be-tested object, and transmit the collected Raman spectrum data to the touch screen processing device, wherein the Raman spectrum data comprises a plurality of Raman spectrum sub-data, and each Raman spectrum sub-data comprises first Raman spectrum data, second Raman spectrum data and third Raman spectrum data; the touch screen processing device is configured to perform the following steps of tissue abnormality detection and laser output: receiving the Raman spectrum data transmitted by the Raman detection information acquisition device; based on the Raman spectrum data, performing tissue abnormality detection on the to-be-tested object to control the semiconductor laser output treatment device to output laser corresponding to the Raman spectrum data to a region where the to-be-tested object is located.

[0009] Optionally, the Raman pump light narrow band filter is replaced through a pluggable slot.

[0010] Optionally, the replaceable focusing mirror is replaced through a pluggable replacement mode or a threaded replacement mode.

[0011] Optionally, the excitation light output by the Raman excitation light output device reaches the collimating mirror through the excitation light transmission fiber, and then the excitation light is collimated by the collimating mirror, and then the collimated excitation light reaches the object to be measured through the replaceable focusing mirror, wherein the replaceable focusing mirror focuses the collimated excitation light to the area where the object to be measured is located; the object to be measured emits Raman scattered light under the action of the excitation light; the replaceable focusing mirror focuses the Raman scattered light to the Raman pump light narrow band pass filter, and enters the Raman signal light transmission fiber through the reflection of the Raman pump light narrow band pass filter and the reflecting mirror, and then reaches the first replaceable dichroic mirror through the Raman signal light transmission fiber, and the first replaceable dichroic mirror reflects the Raman scattered light of the first preset wavelength range from the Raman scattered light to the first charge coupled device camera, to obtain the first analog electrical signal corresponding to the Raman scattered light of the first preset wavelength range; the Raman scattered light after the Raman scattered light of the first preset wavelength range is separated by the first replaceable dichroic mirror, the Raman scattered light of the second preset wavelength range contained in the Raman scattered light is separated and reflected to the second charge coupled device camera through the second replaceable dichroic mirror, to obtain the second analog electrical signal corresponding to the Raman scattered light of the second preset wavelength range; the Raman scattered light after the Raman scattered light of the first preset wavelength range and the Raman scattered light of the second preset wavelength range are separated by the first replaceable dichroic mirror and the second replaceable dichroic mirror, the Raman scattered light of the third preset wavelength range is reflected to the third charge coupled device camera through the third replaceable dichroic mirror, to obtain the third analog electrical signal corresponding to the Raman scattered light of the third preset wavelength range.

[0012] Optionally, the first analog electrical signal, the second analog electrical signal and the third analog electrical signal are transmitted to the analog-to-digital converter through the host computer connection line; the analog-to-digital converter is configured to convert the first analog electrical signal into first Raman spectrum data; the analog-to-digital converter is configured to convert the second analog electrical signal into second Raman spectrum data; and the analog-to-digital converter is configured to convert the third analog electrical signal into third Raman spectrum data.

[0013] Optionally, the touch screen processing device is further configured to perform tissue abnormality detection on the object to be detected based on the above-mentioned Raman spectrum data to control the semiconductor laser output treatment device to output laser corresponding to the Raman spectrum data to the area where the object to be detected is located by the following steps: obtaining incident wavelength information of excitation light corresponding to the Raman spectrum data; for each of the Raman spectrum sub-data included in the Raman spectrum data, performing the following Raman detection processing: based on the incident wavelength information and the Raman spectrum sub-data, generating a set of Raman spectrum data point information corresponding to the Raman spectrum sub-data; generating a Raman spectrum diagram corresponding to the Raman spectrum sub-data based on the set of Raman spectrum data point information; performing spectral diagram analysis processing on the Raman spectrum diagram to obtain Raman tissue detection information corresponding to the object to be detected; displaying each of the obtained Raman tissue detection information on a preset detection page; in response to detecting that at least one of the Raman tissue detection information represents an abnormality, displaying a laser output control, a start time input box and an end time input box on the detection page; in response to detecting an input operation acting on the start time input box, determining the input information corresponding to the output start time input box as start time information; in response to detecting an input operation acting on the end time input box, determining the input corresponding to the end time input box as end time information; in response to detecting a selection operation acting on the laser output control, controlling the semiconductor laser output treatment device to output laser corresponding to the at least one Raman tissue detection information representing an abnormality to the area where the object to be detected is located during a time period corresponding to the start time information and the end time information.

[0014] In a second aspect, some embodiments of the present disclosure provide a laser output control method applied to a touch screen processing device included in the above-mentioned laser detection and treatment all-in-one machine, comprising: receiving Raman spectrum data transmitted by the above-mentioned Raman detection information acquisition device; based on the above-mentioned Raman spectrum data, performing tissue abnormality detection on the object to be detected to control the semiconductor laser output treatment device to output laser corresponding to the Raman spectrum data to the area where the object to be detected is located.

[0015] The above various embodiments of the present disclosure have the following beneficial effects: the laser detection and treatment all-in-one machine of some embodiments of the present disclosure improves the laser treatment effect and reduces the operation treatment time. Specifically, the reason for poor laser treatment effect and long operation treatment time is that the traditional laser output device has the function of destroying or resecting the abnormal human tissue, and does not have the function of detecting the abnormal human tissue (for example, lesion detection, cancer detection). When the traditional laser output device is used to resect the abnormal tissue, the laser output device without detection function is limited to the emission of laser, and cannot detect the target tissue in real time or instantaneously, which increases the damage to normal tissue and reduces the laser treatment effect. In order to accurately and completely resect the abnormal tissue, multiple abnormality detections of the abnormal tissue are required, and in the case of using other detection devices (for example, X-ray tomography (CT) device) to detect the abnormal tissue, more time is required to prepare the device, position the patient, and the detection operation steps are numerous, which increases the operation treatment time. Based on this, the laser detection and treatment all-in-one machine of some embodiments of the present disclosure includes a Raman detection information acquisition device, a semiconductor laser output treatment device, and a touch screen processing device. The Raman detection information acquisition device includes a Raman excitation light output device, an excitation light transmission optical fiber, a collimating mirror, a Raman pump light narrow band filter, a replaceable focusing mirror, a reflecting mirror, a Raman signal light transmission optical fiber, a first replaceable dichroic mirror, a second replaceable dichroic mirror, a third replaceable dichroic mirror, a first charge-coupled device camera, a second charge-coupled device camera, a third charge-coupled device camera, a host computer connection, and an analog-to-digital converter. The Raman excitation light output device is connected to the excitation light transmission optical fiber through a coaxial radio frequency connector. Thus, the Raman detection information acquisition device can be used to collect the Raman spectrum data of the object to be detected in real time. The Raman detection information acquisition device is used to collect the Raman spectrum data of the object to be detected, and transmit the collected Raman spectrum data to the touch screen processing device. The Raman spectrum data includes various Raman spectrum sub-data, and the various Raman spectrum sub-data includes first Raman spectrum data, second Raman spectrum data, and third Raman spectrum data. The touch screen processing device is configured to perform the following steps of tissue abnormality detection and laser output: receiving the Raman spectrum data transmitted by the Raman detection information acquisition device; based on the Raman spectrum data, detecting the tissue abnormality of the object to be detected to control the semiconductor laser output treatment device to output laser corresponding to the Raman spectrum data to the area where the object to be detected is located. Thus, the touch screen processing device included in the laser detection and treatment all-in-one machine can be used to analyze the Raman spectrum data in real time to control the semiconductor laser output treatment device to output laser. The laser detection and treatment all-in-one machine can collect the Raman spectrum data of the object to be detected (such as human tissue) in real time through the Raman detection information acquisition device to detect the tissue abnormality.The Raman detection information can be collected in real time, and the abnormal tissue detection can be performed by the touch screen processing device to control the semiconductor laser output treatment device to output the laser corresponding to the Raman spectrum data, so as to reduce the damage to normal tissues, improve the laser treatment effect, and simplify the detection operation steps and shorten the operation time. BRIEF DESCRIPTION OF DRAWINGS

[0016] The above and other features, advantages, and aspects of embodiments of the present disclosure will become more apparent by describing in detail some embodiments thereof with reference to the attached drawings. The same or similar components have the same or similar reference numbers throughout the drawings. It should be understood that the drawings are schematic and elements and features are not necessarily to scale.

[0017] Figure 1 is a structural schematic diagram of some embodiments of the Raman detection information collection device according to the present disclosure;

[0018] Figure 2 is a structural schematic diagram of some embodiments of the semiconductor laser output treatment device according to the present disclosure;

[0019] Figure 3 is a flowchart of some embodiments of the laser output control method suitable for implementing the present disclosure;

[0020] Figure 4 is a structural schematic diagram of some embodiments of the laser detection and treatment all-in-one machine according to the present disclosure;

[0021] Figure 5 is a physical diagram of the internal test product of the laser detection and treatment all-in-one machine according to the present disclosure. DETAILED DESCRIPTION

[0022] Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although some embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure can be implemented in various forms, and should not be interpreted as being limited to the embodiments set forth herein. On the contrary, these embodiments are provided to make the present disclosure more thorough and complete. It should be understood that the drawings and embodiments of the present disclosure are only for exemplary purposes, and are not intended to limit the scope of protection of the present disclosure.

[0023] It should also be noted that, for the convenience of description, only the parts related to the present application are shown in the drawings. The embodiments in the present disclosure and the features in the embodiments can be combined with each other without conflict.

[0024] It should be noted that the terms "first", "second", and the like in the present disclosure are merely intended to distinguish different devices, modules or units, and do not imply the sequence of execution of the functions of these devices, modules or units or the mutual dependency of these devices, modules or units.

[0025] It should be noted that the terms "one", "multiple" in the present disclosure are illustrative rather than restrictive, and those skilled in the art should understand that "one" or "multiple" should be understood as "one or more" unless otherwise explicitly indicated in the context.

[0026] The names of the messages or information exchanged between the plurality of devices in the embodiments of the present disclosure are merely for illustrative purposes, and are not intended to limit the scope of the messages or information.

[0027] The present disclosure will be described in detail below with reference to the accompanying drawings and in conjunction with embodiments.

[0028] First, please refer to Figure 1 and Figure 4 , Figure 4 shows the structural schematic diagram of some embodiments of the laser detection and treatment all-in-one machine of the present disclosure. The above laser detection and treatment all-in-one machine includes a Raman detection information acquisition device 401, a semiconductor laser output treatment device 403, and a touch screen processing device 402. Figure 1 shows the structural schematic diagram of some embodiments of the Raman detection information acquisition device 401 of the present disclosure. The above Raman detection information acquisition device 401 includes a Raman excitation light output device 101, an excitation light transmission optical fiber 102, a collimating mirror 103, a Raman pump light narrow band filter 104, a replaceable focusing mirror 105, a reflecting mirror 107, a Raman signal light transmission optical fiber 108, a first replaceable dichroic mirror 109, a second replaceable dichroic mirror 110, a third replaceable dichroic mirror 111, a first charge-coupled device camera 1121, a second charge-coupled device camera 1122, a third charge-coupled device camera 1123, a host computer connection 112, and an analog-to-digital converter. The above Raman excitation light output device 101 is connected with the above excitation light transmission optical fiber 102 through a coaxial radio frequency connector.

[0029] The Raman excitation light output device 101 can be a device for outputting Raman excitation light. The Raman excitation light can be light for exciting a target object (e.g., human tissue) to generate a Raman scattering signal. For example, the Raman excitation light output device 101 can be a Raman laser. The excitation light transmission optical fiber 102 can be an optical fiber (e.g., a handpiece optical fiber) for transmitting Raman excitation light. The Raman pump light narrowband filter 104 can be a reflective filter for transmitting Raman excitation light and reflecting Raman scattering light. The replaceable focusing lens 105 can be a focusing lens for focusing Raman excitation light onto the target object 106. The Raman signal light transmission optical fiber 108 can be an optical fiber for transmitting Raman scattering light. The first replaceable dichroic mirror 109 can be a dichroic mirror for separating light in the Raman scattering light that satisfies a first predetermined wavelength band to the first charge-coupled device camera 1121. The second replaceable dichroic mirror 110 can be a dichroic mirror for separating light in the Raman scattering light that satisfies a second predetermined wavelength band to the second charge-coupled device camera 1122. The third replaceable dichroic mirror 111 can be a dichroic mirror for separating light in the Raman scattering light that satisfies a third predetermined wavelength band to the third charge-coupled device camera 1123. The first charge-coupled device camera 1121, the second charge-coupled device camera 1122, and the third charge-coupled device camera 1123 can be CCD cameras. For example, the first charge-coupled device camera 1121 can be an ultraviolet CCD camera. The second charge-coupled device camera 1122 can be a visible light CCD camera. The third charge-coupled device camera 1123 can be a near-infrared CCD camera.

[0030] The Raman detection information acquisition device 401 is configured to acquire Raman spectrum data of the target object 106 and transmit the acquired Raman spectrum data to the touch screen processing device 402. The Raman spectrum data includes a plurality of Raman spectrum sub-data, and each Raman spectrum sub-data includes first Raman spectrum data, second Raman spectrum data, and third Raman spectrum data. The touch screen processing device 402 is configured to perform the following steps of tissue abnormality detection and laser output: receiving the Raman spectrum data transmitted by the Raman detection information acquisition device 401. Based on the Raman spectrum data, the target object 106 is detected for tissue abnormalities to control the semiconductor laser output treatment device 403 to output laser corresponding to the Raman spectrum data to the area 228 where the target object 106 is located. The touch screen processing device 402 can control the Raman detection information acquisition device 401 to acquire Raman spectrum data in real time before or after the semiconductor laser output treatment device 403 outputs laser to control the semiconductor laser output treatment device 403 to output or re-output laser corresponding to the Raman spectrum data to the area 228 where the target object 106 is located through a timing task.

[0031] The Raman detection information collection device 401 can be connected to the touch screen processing device 402 (such as a touch screen computing device) through a USB line or other high-speed data transmission line (such as an Ethernet line). The touch screen processing device 402 can communicate through a serial communication interface (such as RS-232, RS-485, etc.), an Ethernet interface, or other high-speed communication interfaces to control the semiconductor laser output treatment device 403 to output laser corresponding to the Raman spectrum data to the area 228 where the object 106 to be detected is located.

[0032] Optionally, the Raman pump light narrow band filter 104 is replaced through a pluggable slot.

[0033] Optionally, the replaceable focusing mirror 105 is replaced through a pluggable replacement or a threaded replacement.

[0034] Optionally, the excitation light output by the Raman excitation light output device 101 reaches the collimating mirror 103 through the excitation light transmission optical fiber 102, and then the excitation light is collimated by the collimating mirror 103, and then the collimated excitation light reaches the object to be measured 106 through the replaceable focusing mirror 105. The replaceable focusing mirror 105 focuses the collimated excitation light to the area 228 where the object to be measured 106 is located. The object to be measured 106 emits Raman scattered light under the action of the excitation light. The replaceable focusing mirror 105 focuses the Raman scattered light to the Raman pump light narrow band pass filter 104, and the Raman scattered light enters the Raman signal light transmission optical fiber 108 through the reflection of the Raman pump light narrow band pass filter 104 and the reflecting mirror 107, and then reaches the first replaceable dichroic mirror 109 through the Raman signal light transmission optical fiber 108. The first replaceable dichroic mirror 109 reflects the Raman scattered light in the first preset wavelength range from the Raman scattered light to the first charge coupled device camera 1121, and obtains the first analog electrical signal corresponding to the Raman scattered light in the first preset wavelength range. The Raman scattered light after the Raman scattered light in the first preset wavelength range is separated by the first replaceable dichroic mirror 109 is reflected to the second charge coupled device camera 1122 by the second replaceable dichroic mirror 110, and the second analog electrical signal corresponding to the Raman scattered light in the second preset wavelength range is obtained. The Raman scattered light after the Raman scattered light in the first preset wavelength range and the Raman scattered light in the second preset wavelength range are separated by the first replaceable dichroic mirror 109 and the second replaceable dichroic mirror 110 is reflected to the third charge coupled device camera 1123 by the third replaceable dichroic mirror 111, and the third analog electrical signal corresponding to the Raman scattered light in the third preset wavelength range is obtained.

[0035] Optionally, the first analog electrical signal, the second analog electrical signal and the third analog electrical signal are transmitted to the analog-to-digital converter through the host computer connection. The analog-to-digital converter is configured to convert the first analog electrical signal into first Raman spectrum data. The analog-to-digital converter is configured to convert the second analog electrical signal into second Raman spectrum data. The analog-to-digital converter is configured to convert the third analog electrical signal into third Raman spectrum data.

[0036] In the process of using the technical solutions to solve the problems mentioned in the background, the following problems are often accompanied:

[0037] Generally, the laser output by the existing semiconductor laser output treatment equipment is usually single laser. When treating abnormal tissues (for example, lesions or cancer), due to the difference in the absorption characteristics of different tissues to the laser, the wavelength of the single laser is usually fixed, and the applicable range of the laser treatment is small. At the same time, the same tissue may face multiple lesion conditions, and the single laser may not be able to accurately treat the lesion tissue with multiple lesions, resulting in poor laser treatment effect of the semiconductor laser output treatment equipment.

[0038] In view of the above technical problems, the inventors decided to adopt the following solutions:

[0039] Further reference is made to Figure 2 , Figure 2A structural diagram of some embodiments of the semiconductor laser output treatment device 403 of the present disclosure is shown. The above semiconductor laser output treatment device 403 comprises a first laser diode 201, a second laser diode 202, a third laser diode 203, a fourth laser diode 204, a fifth laser diode 205, a sixth laser diode 206, a seventh laser diode 207, a first volume Bragg grating 208, a second volume Bragg grating 209, a third volume Bragg grating 210, a first slow-axis collimator 211, a second slow-axis collimator 201, a third slow-axis collimator 213, a fourth slow-axis collimator 214, a fifth slow-axis collimator 215, a sixth slow-axis collimator 216, a seventh slow-axis collimator 217, a mirror 218, a first dichroic mirror 219, a second dichroic mirror 220, a third dichroic mirror 221, a fourth dichroic mirror 222, a fifth dichroic mirror 223, a sixth dichroic mirror 224, an aspheric focusing lens 225, a laser output window 226, a coupler dustproof window 227. Among them, each of the above first laser diode 201, the above second laser diode 202, the above third laser diode 203, the above fourth laser diode 204, the above fifth laser diode 205, the above sixth laser diode 206, and the above seventh laser diode 207 can be a laser diode for generating a preset wavelength or a preset wavelength range. Each of the above first volume Bragg grating 208, the above second volume Bragg grating 209, and the above third volume Bragg grating 210 can be used to stabilize the laser output wavelength and narrow the linewidth. Each of the above first volume Bragg grating 208, the second volume Bragg grating 209, the third volume Bragg grating 210, the first slow-axis collimator 211, the second slow-axis collimator 201, the third slow-axis collimator 213, the fourth slow-axis collimator 214, the fifth slow-axis collimator 215, the sixth slow-axis collimator 216, and the seventh slow-axis collimator 217 can be a slow-axis collimator located at a preset position of a corresponding one of the above first laser diode 201, the above second laser diode 202, the above third laser diode 203, the above fourth laser diode 204, the above fifth laser diode 205, the above sixth laser diode 206, and the above seventh laser diode 207. For example, the first laser diode 201 corresponds to the first slow-axis collimator 211.

[0040] The first preset wavelength laser emitted by the first laser diode 201 passes through the first slow axis collimation mirror 211, is reflected by the reflector 218, and passes through the first dichroic filter 219, the second dichroic filter 220, the third dichroic filter 221, the fourth dichroic filter 222, the fifth dichroic filter 223, the sixth dichroic filter 224, and reaches the aspheric focusing mirror 225. The aspheric focusing mirror 225 focuses the first laser to the laser output window 226, and then outputs to the laser treatment area 228 through the coupler dustproof window 227, wherein the laser treatment area 228 can be Figure 1The laser beam of the second predetermined wavelength emitted by the second laser diode passes through the second slow-axis collimator, is reflected by the first dichroic filter, and then passes through the second, third, fourth, fifth, and sixth dichroic filters 222 and 224 to reach the aspheric focusing mirror 225. The aspheric focusing mirror 225 focuses the second laser beam onto the laser output window 226, which is then output to the laser treatment area 228 through the coupler dustproof window 227. The laser beam of the third predetermined wavelength emitted by the third laser diode passes through the first volume Bragg grating and the third slow-axis collimator, is reflected by the second dichroic filter, and then passes through the third, fourth, fifth, and sixth dichroic filters to reach the aspheric focusing mirror 225. The aspheric focusing mirror 225 focuses the third laser beam onto the laser output window 226, which is then output to the laser treatment area 228 through the coupler dustproof window 227. The laser light of the fourth predetermined wavelength emitted by the fourth laser diode passes through the second volume Bragg grating and the fourth slow-axis collimator, is reflected by the third dichroic filter, passes through the fourth dichroic filter 222, the fifth dichroic filter, and the sixth dichroic filter, and arrives at the aspheric focusing mirror 225. The aspheric focusing mirror 225 focuses the third laser light onto the laser output window 226, which is then output to the laser treatment area 228 through the coupler dustproof window 227. The laser light of the fifth predetermined wavelength emitted by the fifth laser diode passes through the third volume Bragg grating and the fifth slow-axis collimator, is reflected by the fourth dichroic filter 222, passes through the fifth dichroic filter and the sixth dichroic filter, and arrives at the aspheric focusing mirror 225. The aspheric focusing mirror 225 focuses the fifth laser light onto the laser output window 226, which is then output to the laser treatment area 228 through the coupler dustproof window 227. The laser beam of the sixth preset wavelength emitted by the sixth laser diode passes through the sixth slow-axis collimator, is reflected by the fifth dichroic filter, passes through the sixth dichroic filter, and reaches the aspheric focusing mirror 225. The aspheric focusing mirror 225 focuses the fifth laser beam onto the laser output window 226, which is then output to the laser treatment area 228 through the coupler dustproof window 227. The laser beam of the seventh preset wavelength emitted by the seventh laser diode passes through the seventh slow-axis collimator, is reflected by the sixth dichroic filter, and reaches the aspheric focusing mirror 225. The aspheric focusing mirror 225 focuses the seventh laser beam onto the laser output window 226, which is then output to the laser treatment area 228 through the coupler dustproof window 227.

[0041] The multi-laser diode configuration structure of the semiconductor laser output treatment device 403 and the optical path design between the various optical elements included therein are related content as one of the application points of the embodiments of the present disclosure, which solves the technical problem of "smaller application range and poorer laser treatment effect of laser treatment of the semiconductor laser output treatment device". The factors that cause the smaller application range and poorer laser treatment effect of laser treatment of the semiconductor laser output treatment device are often as follows: the laser output by the existing semiconductor laser output treatment device is usually single laser, and when treating abnormal tissues (for example, lesions or cancer), due to the difference in absorption characteristics of different tissues to laser, the wavelength of the single laser is usually fixed, and the application range of laser treatment is small. At the same time, the same tissue may face multiple pathological conditions, and the single laser may not be able to accurately treat the pathological tissue with multiple pathological conditions, resulting in poorer laser treatment effect of the semiconductor laser output treatment device. If the above factors are solved, the application range of laser treatment of the semiconductor laser output treatment device can be widened and the laser treatment effect can be improved. In order to achieve this effect, the present disclosure adopts the multi-laser diode configuration structure of the semiconductor laser output treatment device and the optical path design between the various optical elements included therein. Specifically, the semiconductor laser output treatment device of the present disclosure can be built-in with multiple laser diodes in parallel during production. Here, the first laser diode, the second laser diode, the third laser diode, the fourth laser diode, the fifth laser diode, the sixth laser diode, and the seventh laser diode are built-in in the semiconductor laser output treatment device. In this way, multi-band laser can be generated to solve the problem of difference in absorption characteristics of different tissues to laser, thereby widening the application range of laser treatment. At the same time, different laser diodes in the above-mentioned various laser diodes can be designed to emit laser of different wavelengths, and by combining multiple laser diodes, multi-wavelength laser can be simultaneously output to the area where the pathological tissue with multiple pathological conditions is located based on the optical path design between the various optical elements (for example, Bragg grating, slow-axis collimator, mirror, dichroic filter, and aspheric focusing lens) included in the semiconductor laser output treatment device, thereby combining multiple wavelengths of laser to accurately treat the tissue with multiple pathological conditions, thereby improving the laser treatment effect of the semiconductor laser output treatment device.

[0042] Optionally, in some embodiments, the above-mentioned touch screen processing device can be further configured to perform tissue abnormality detection on the above-mentioned object to be tested based on the above-mentioned Raman spectrum data to control the above-mentioned semiconductor laser output treatment device to output laser corresponding to the Raman spectrum data to the area where the above-mentioned object to be tested is located.

[0043] In the first step, the touch screen processing device obtains the incident wavelength information of the excitation light corresponding to the Raman spectrum data. In practice, the touch screen processing device can obtain the incident wavelength information of the excitation light corresponding to the Raman spectrum data from a preset storage file (for example, a preset Word file). The incident wavelength information can represent the wavelength of the Raman excitation light. For example, the incident wavelength information can be “532 nm”.

[0044] In the second step, the touch screen processing device performs the following Raman detection processing on each of the Raman spectrum sub-data included in the Raman spectrum data:

[0045] In the first sub-step, the touch screen processing device generates a set of Raman spectrum data point information corresponding to the Raman spectrum sub-data based on the incident wavelength information and the Raman spectrum sub-data. The Raman spectrum sub-data can include each Raman scattered light data point information. Each Raman scattered light data point information includes a scattered light wavelength and an intensity. For example, the Raman spectrum sub-data can be “(wavelength: 600 nm, intensity: 100), (wavelength: 700 nm, intensity: 120), (wavelength: 800 nm, intensity: 150)”. In practice, for each of the Raman scattered light data point information included in the Raman spectrum sub-data, the touch screen processing device can determine a first value as the ratio of a preset value to the wavelength corresponding to the incident wavelength information. Then the touch screen processing device can determine a second value as the ratio of the preset value to the wavelength included in the Raman scattered light data point information. After that, the touch screen processing device can determine a Raman scattered light offset as the difference between the first value and the second value. Next, the touch screen processing device can determine a Raman spectrum data point information as the Raman scattered light offset and the intensity included in the Raman scattered light data point information. Finally, the touch screen processing device can determine the generated each Raman spectrum data point information as the set of Raman spectrum data point information corresponding to the Raman spectrum sub-data.

[0046] In the second sub-step, the touch screen processing device generates a Raman spectrum graph corresponding to the Raman spectrum sub-data based on the set of Raman spectrum data point information. In practice, the touch screen processing device can call a drawing tool (for example, Matplotlib (Python library)) to generate a curve graph corresponding to the set of Raman spectrum data point information as the Raman spectrum graph.

[0047] A third sub-step is performed to analyze the Raman spectrum and obtain Raman tissue detection information corresponding to the object to be detected. In practice, the touch screen processing device can compare the Raman spectrum with each pre-stored spectrum in a pre-constructed spectrum database to obtain each analysis similarity. The pre-constructed spectrum database can be a database for storing spectra and abnormal information corresponding to the spectra. Each analysis similarity can be represented by a cosine similarity. Then, in response to determining that at least one analysis similarity is greater than a preset value, the touch screen processing device can determine the analysis similarity with the maximum value as a target analysis similarity. Then, the touch screen processing device can determine the abnormal information corresponding to the target analysis similarity as the Raman tissue detection information. The Raman tissue detection information can be text information, for example, the Raman tissue detection information can be “abnormal detection, the frequency and intensity of amide I and amide III bands of protein have changed compared with normal tissue”. In response to determining that there is no analysis similarity greater than the preset value, the touch screen processing device can determine text information representing normal detection as the Raman tissue detection information.

[0048] A third step is performed to display each Raman tissue detection information obtained in the first step on a preset detection page. The preset detection page can be a page for displaying Raman tissue detection information and controlling the semiconductor laser output treatment device to output laser.

[0049] A fourth step is performed to display a laser output control, a start time input box and an end time input box on the detection page in response to detecting that at least one Raman tissue detection information in the Raman tissue detection information represents abnormal detection. The laser output control can be a page interactive element for controlling the semiconductor laser output treatment device to output laser. The start time input box can be a page interactive element for inputting a start time of laser output. The end time input box can be a page interactive element for inputting an end time of laser output.

[0050] A fifth step is performed to determine input information corresponding to the start time input box as start time information in response to detecting an input operation acting on the start time input box.

[0051] A sixth step is performed to determine input information corresponding to the end time input box as end time information in response to detecting an input operation acting on the end time input box.

[0052] In the seventh step, in response to detecting the selection operation on the laser output control, the semiconductor laser output treatment device is controlled to output laser corresponding to the at least one Raman tissue detection information representing the abnormality to the region where the object is located during the time period corresponding to the start time information and the end time information.

[0053] Reference will now be made to the following description Figure 3 , Figure 3 A laser output control method applied to a laser detection and treatment all-in-one machine according to the present disclosure is shown. The laser output control method comprises the following steps:

[0054] In step 301, Raman spectrum data transmitted by a Raman detection information acquisition device is received.

[0055] In some embodiments, the execution subject of the laser output control method (such as a touch screen processing device) can receive the Raman spectrum data transmitted by the Raman detection information acquisition device.

[0056] In step 302, based on the Raman spectrum data, tissue abnormality detection is performed on the object to be tested to control the semiconductor laser output treatment device to output laser corresponding to the Raman spectrum data to the region where the object to be tested is located.

[0057] In some embodiments, the execution subject can perform tissue abnormality detection on the object to be tested based on the Raman spectrum data to control the semiconductor laser output treatment device to output laser corresponding to the Raman spectrum data to the region where the object to be tested is located.

[0058] The above various embodiments of the present disclosure have the following beneficial effects: the laser detection and treatment all-in-one machine of some embodiments of the present disclosure improves the laser treatment effect and reduces the operation treatment time. Specifically, the reason for poor laser treatment effect and long operation treatment time is that the traditional laser output device has the function of destroying or resecting the abnormal human tissue, and does not have the function of detecting the abnormal human tissue (for example, lesion detection, cancer detection). When the traditional laser output device is used to resect the abnormal tissue, the laser output device without detection function is limited to the emission of laser, and cannot detect the target tissue in real time or instantaneously, which increases the damage to normal tissue and reduces the laser treatment effect. In order to accurately and completely resect the abnormal tissue, multiple abnormality detections of the abnormal tissue are required, and in the case of using other detection devices (for example, X-ray tomography (CT) device) to detect the abnormal tissue, more time is required to prepare the device, position the patient, and the detection operation steps are numerous, which increases the operation treatment time. Based on this, the laser detection and treatment all-in-one machine of some embodiments of the present disclosure includes a Raman detection information acquisition device, a semiconductor laser output treatment device, and a touch screen processing device. The Raman detection information acquisition device includes a Raman excitation light output device, an excitation light transmission optical fiber, a collimating mirror, a Raman pump light narrow band filter, a replaceable focusing mirror, a reflecting mirror, a Raman signal light transmission optical fiber, a first replaceable dichroic mirror, a second replaceable dichroic mirror, a third replaceable dichroic mirror, a first charge-coupled device camera, a second charge-coupled device camera, a third charge-coupled device camera, a host computer connection, and an analog-to-digital converter. The Raman excitation light output device is connected to the excitation light transmission optical fiber through a coaxial radio frequency connector. Thus, the Raman detection information acquisition device can be used to collect the Raman spectrum data of the object to be detected in real time. The Raman detection information acquisition device is used to collect the Raman spectrum data of the object to be detected, and transmit the collected Raman spectrum data to the touch screen processing device. The Raman spectrum data includes various Raman spectrum sub-data, and the various Raman spectrum sub-data includes first Raman spectrum data, second Raman spectrum data, and third Raman spectrum data. The touch screen processing device is configured to perform the following steps of tissue abnormality detection and laser output: receiving the Raman spectrum data transmitted by the Raman detection information acquisition device; based on the Raman spectrum data, detecting the tissue abnormality of the object to be detected to control the semiconductor laser output treatment device to output the laser corresponding to the Raman spectrum data to the area where the object to be detected is located. Thus, the touch screen processing device included in the laser detection and treatment all-in-one machine can be used to analyze the Raman spectrum data in real time to control the semiconductor laser output treatment device to output the treatment laser. The laser detection and treatment all-in-one machine can collect the Raman spectrum data of the object to be detected (such as human tissue) in real time through the Raman detection information acquisition device to detect the tissue abnormality.The Raman detection information collected in real time can be used to detect tissue abnormalities through a touch screen processing device, so as to control the semiconductor laser output treatment device to output laser corresponding to the Raman spectrum data, reduce the damage to normal tissues, improve the laser treatment effect, and at the same time, without the need for more time to prepare the device and position the patient, the detection operation steps are simplified, and the operation treatment time is shortened.

[0059] The above description is only some of the preferred embodiments of the present disclosure and an explanation of the principles of the technology used. Those skilled in the art should understand that the scope of the application involved in the embodiments of the present disclosure is not limited to the technical solutions formed by the specific combination of technical features, and should also cover other technical solutions formed by any combination of technical features or their equivalent features without departing from the inventive concept. For example, the technical solutions formed by replacing the features with the technical features disclosed in the embodiments of the present disclosure (but not limited to) having similar functions with each other.

Claims

1. A laser detection and treatment all-in-one machine, characterized in that: include: Raman detection information acquisition equipment, semiconductor laser output treatment equipment, touch screen processing equipment; The Raman detection information acquisition device includes a Raman excitation light output device, an excitation light transmission fiber, a collimating mirror, a Raman pump light narrow bandpass filter, a replaceable focusing mirror, a reflector, a Raman signal light transmission fiber, a first replaceable dichroic filter, a second replaceable dichroic filter, a third replaceable dichroic filter, a first charge-coupled device camera, a second charge-coupled device camera, a third charge-coupled device camera, a host computer connection, and an analog-to-digital converter, wherein the Raman pump light narrow bandpass filter is a reflective filter for transmitting Raman excitation light and reflecting Raman scattered light; The Raman excitation light output device is connected to the excitation light transmission optical fiber via a coaxial radio frequency connector; The Raman detection information acquisition device is used to acquire Raman spectrum data of the object to be detected, and transmit the acquired Raman spectrum data to the touch screen processing device, wherein the Raman spectrum data includes various Raman spectrum sub-data, and the various Raman spectrum sub-data include first Raman spectrum data, second Raman spectrum data, and third Raman spectrum data; The touch screen processing device is configured to perform the following tissue abnormality detection and laser output steps: Receiving Raman spectrum data transmitted by the Raman detection information acquisition device; Based on the Raman spectral data, tissue abnormality detection is performed on the object to be measured to control the semiconductor laser output treatment device to output laser light corresponding to the Raman spectral data to the area where the object to be measured is located, wherein the semiconductor laser output treatment device includes a first laser diode, a second laser diode, a third laser diode, a fourth laser diode, a fifth laser diode, a sixth laser diode, a seventh laser diode, a first volume Bragg grating, a second volume Bragg grating, a third volume Bragg grating, a first slow-axis collimator, a second slow-axis collimator, a third slow-axis collimator, a fourth slow-axis collimator, a fifth slow-axis collimator, a sixth slow-axis collimator, a seventh slow-axis collimator, a reflecting mirror, a first dichroic plate, a second dichroic plate, a third dichroic plate, a fourth dichroic plate, a fifth dichroic plate, a sixth dichroic plate, an aspheric focusing mirror, a laser output window, and a coupler dust-proof window.

2. The integrated laser detection and treatment device according to claim 1, characterized in that: include: The Raman pump light narrow bandpass filter is replaced through a pluggable slot.

3. The integrated laser detection and treatment device according to claim 1, characterized in that: include: The replaceable focusing lens is replaced by a pluggable replacement method or a threaded replacement method.

4. The integrated laser detection and treatment device according to claim 1, characterized in that: include: The excitation light output by the Raman excitation light output device reaches the collimator through the excitation light transmission optical fiber, and then the excitation light is collimated by the collimator. Thereafter, the collimated excitation light reaches the object to be measured through the replaceable focusing lens, wherein the replaceable focusing lens focuses the collimated excitation light onto the area where the object to be measured is located; The object to be measured emits Raman scattered light under the action of the excitation light; The replaceable focusing mirror focuses the Raman scattered light onto the Raman pump light narrow bandpass filter, and the Raman scattered light enters the Raman signal light transmission optical fiber after being reflected by the Raman pump light narrow bandpass filter and the reflector. Thereafter, the Raman scattered light reaches the first replaceable dichroic filter through the Raman signal light transmission optical fiber. The first replaceable dichroic filter separates the Raman scattered light in a first preset wavelength range from the Raman scattered light and reflects the Raman scattered light to the first charge-coupled device camera, thereby obtaining a first analog electrical signal corresponding to the Raman scattered light in the first preset wavelength range. The Raman scattered light is separated by the first replaceable dichroic filter from the Raman scattered light in the first preset wavelength range, and the Raman scattered light is separated by the second replaceable dichroic filter from the Raman scattered light in the second preset wavelength range and reflected to the second charge-coupled device camera to obtain a second analog electrical signal corresponding to the Raman scattered light in the second preset wavelength range. After the first replaceable dichroic filter and the second replaceable dichroic filter separate the Raman scattered light in the first preset wavelength range and the Raman scattered light in the second preset wavelength range, the Raman scattered light in the third preset wavelength range is reflected to the third charge-coupled device camera through the third replaceable dichroic filter, thereby obtaining a third analog electrical signal corresponding to the Raman scattered light in the third preset wavelength range.

5. The integrated laser detection and treatment device according to claim 4, characterized in that: include: The first analog electrical signal, the second analog electrical signal and the third analog electrical signal are transmitted to the analog-to-digital converter via the host computer connection; The analog-to-digital converter is used to convert the first analog electrical signal into first Raman spectrum data; The analog-to-digital converter is used to convert the second analog electrical signal into second Raman spectrum data; The analog-to-digital converter is used to convert the third analog electrical signal into third Raman spectrum data.

6. The integrated laser detection and treatment device according to claim 1, wherein: The touch screen processing device is further configured to perform tissue abnormality detection on the object to be tested based on the Raman spectrum data through the following steps, so as to control the semiconductor laser output treatment device to output laser light corresponding to the Raman spectrum data to the area where the object to be tested is located, including: Acquiring incident wavelength information of the excitation light corresponding to the Raman spectrum data; The following Raman detection processing is performed on each Raman spectrum sub-data in each Raman spectrum sub-data included in the Raman spectrum data: generating a Raman spectrum data point information set corresponding to the Raman spectrum sub-data based on the incident wavelength information and the Raman spectrum sub-data; generating a Raman spectrum graph corresponding to the Raman spectrum sub-data based on the Raman spectrum data point information set; Performing spectrum analysis on the Raman spectrum to obtain Raman tissue detection information corresponding to the object to be tested; Display the obtained Raman tissue detection information on the preset detection page; In response to detecting that at least one of the Raman tissue detection information indicates a detection abnormality, displaying a laser output control, a start time input box, and an end time input box on the detection page; In response to detecting an input operation acting on the start time input box, determining the input information corresponding to the output start time input box as the start time information; In response to detecting an input operation acting on the end time input box, determining the input corresponding to the end time input box as end time information; In response to detecting a selection operation acting on the laser output control, the semiconductor laser output treatment device is controlled to output a laser corresponding to at least one Raman tissue detection information characterizing an abnormality to the area where the object to be measured is located during a time period corresponding to the start time information and the end time information.

Images