Compound externally-applied gel medicine for treating acne by combining traditional Chinese medicine and western medicine

Abstract

The invention discloses a compound external application gel combining traditional Chinese medicine and western medicine, which is specially designed for treating acne. The medicine integrates traditional Chinese medicine wisdom and modern western medicine efficacy, and aims to quickly relieve acne, regulate body balance, reduce relapse and reduce side effects. Western medicine components comprise malechlorpheniramine, oryzanol, dexamethasone acetate and vitamin B12, and cooperate with traditional Chinese medicine extracts such as artificial musk and pearl to achieve the comprehensive curative effects of resisting inflammation and allergy, improving endocrine and promoting skin repair. The unique preparation process ensures high purity and low toxicity of the medicine, and is suitable for patients of wide age groups. Clinical verifications show that Xinjiaoqing shows debridement speed and user satisfaction superior to those of a conventional therapy in patients of different age groups, especially in young patient groups, the Xinjiaoqing remarkably improves acne symptoms, reduces treatment cycle, improves life quality and treatment compliance, and marks an innovative breakthrough in the field of acne treatment.

Description

Technical Field

[0001] The present invention relates to the field of medicine, and in particular to a compound medicine for treating acne by combining traditional Chinese medicine with modern Western medicine ingredients and a preparation method thereof, aiming to provide a comprehensive treatment method that can not only quickly relieve acne symptoms, but also regulate the balance in the body and reduce the recurrence rate.

[0002] Background technology and innovations

[0003] Acne, as a common skin disease, is especially prevalent among adolescents, causing appearance problems and psychological pressure on patients. Existing treatments include topical antibiotics, retinoids, and oral isotretinoin and other Western medicines. Although effective, long-term use may be accompanied by side effects, such as dry skin, increased photosensitivity, and abnormal liver function. In contrast, traditional Chinese medicine has become the preferred auxiliary treatment for acne due to its overall conditioning and fewer side effects. However, single therapy is often difficult to meet the needs of existing patients. Therefore, it is particularly important to combine the advantages of Chinese and Western medicines to develop a new compound drug for the treatment of acne. Summary of the invention

[0004] The main purpose of the present invention is to provide a compound medicine combining Chinese and Western medicine for treating acne, overcoming the limitations of existing therapies, achieving the effects of rapid disease control, anti-inflammatory effects on the body surface, acting on nerves, reducing recurrence rates, and reducing side effects.

[0005] Technical Solution

[0006] The compound medicine of the present invention comprises the following active ingredients:

[0007] 1. Western medicine ingredients:

[0008] Malechlorpheniramine: A classic antiallergic drug, belonging to the first generation of H1 receptor antagonists. Its main effect is antiallergic effect.

[0009] Oryzanol: Oryzanol is a natural substance extracted from rice bran oil. Its main component is a mixture of triterpenoid (ene) alcohol ferulic acid esters. Its main effects are: improving endocrine balance disorders, sleep disorders, and various syndromes caused by endocrine disorders.

[0010] Dexamethasone acetate: a synthetic adrenal cortex hormone drug with a wide range of pharmacological effects. In this drug, it mainly plays an anti-inflammatory and anti-allergic role. It also reduces the occurrence of autoimmune diseases by inhibiting immune cells.

[0011] Vitamin B12 (cobalamin): An essential component of the human body, it strongly supports the activities of connective tissue and participates in the normal maintenance of the immune system. In this product, it is mainly reflected in the maintenance of the nervous system and the formation of myelin sheaths of nerve fibers.

[0012] 2. Chinese herbal medicine extracts:

[0013] Artificial musk: A medicinal material used in this product to invigorate the mind, promote blood circulation and dredge collaterals, reduce swelling, relieve pain, and have antibacterial and anti-inflammatory effects.

[0014] Pearl: As a traditional Chinese medicinal material, it plays the role of using SOD (superoxide dismutase) in this medicine to remove free radicals, delay aging, detoxify and regenerate muscles, promote the ulceration and healing of acne wounds, and promote tissue regeneration.

[0015] Calamine powder: a commonly used external medicine, in this product it can relieve swelling and pain of contact dermatitis and promote the regeneration and repair of damaged skin and mucous membranes.

[0016] Borax (Na2B4O7·10H2O): A multifunctional chemical substance, it plays a role in reducing swelling, removing toxins and increasing viscosity in this variety.

[0017] Amber: As a traditional Chinese medicinal material, it has a wide range of medicinal value. In this variety, it mainly plays the role of promoting blood circulation and dispersing blood stasis, calming the mind and relieving nervous tension caused by anxiety.

[0018] Sulfur: A toxic multifunctional Chinese medicine. In this product, it mainly plays the role of healing sores and detoxifying, and is used in trace amounts.

[0019] Lanolin: A natural oil extracted from wool that has skin-nourishing properties and acts as an oil-in-water emulsifier to help drugs pass through the skin, thereby promoting drug absorption.

[0020] 3. Other ingredients:

[0021] Calcium bicarbonate, dextrin, sucrose. Mainly used to adjust pH value and thicken.

[0022] Preparation method

[0023] Step 1: Evenly mix the western medicine ingredients in a certain proportion and prepare them into a form for topical application on the skin (face).

[0024] Step 2: The Chinese herbal medicine extract is processed and purified and concentrated using a suitable water-alcohol solvent. The solid powder is mixed and ground. The matrix oil is heated and refined while ensuring the fineness of the paste. After dehydration, resin substances are added to adjust the solidification state.

[0025] Step 3: Mix the western medicine ingredients and the Chinese medicine extracts in a specific proportion, perform secondary extraction, and add appropriate proportions of dextrin and calcium bicarbonate to adjust its paste viscosity.

[0026] Step 4: Add the mixed medicine into the oil to form a uniform paste, cool it to a suitable temperature and then aseptically package it (aluminum tube)

[0027] Step 5: Finally, quality inspection is carried out to determine the appropriate packaging.

[0028] To further describe the above technical solution, the preparation method of dexamethasone acetate and chlorpheniramine maleate comprises the following steps:

[0029] Preparation of dexamethasone acetate

[0030] 10g of the reaction raw material dexamethasone was added to 30g of the dimethyl sulfoxide reaction solvent, and 10g of sodium carbonate was added while stirring to adjust the pH of the reaction solvent to 7. The temperature of the reaction solvent was lowered to 0°C, and 10g of acetic anhydride was slowly added dropwise. The reaction was carried out at a temperature below 15°C for 2-3h. No raw material point was detected by TLC. The reaction was completed. Dexamethasone acetate was added to a water separation bucket. During the process, the temperature was controlled below 10°C to reduce the content of dexamethasone acetate in dimethyl sulfoxide. Finally, the dexamethasone acetate was separated by centrifugation and dried to obtain 10.5g of crude dexamethasone acetate.

[0031] Preparation of chlorpheniramine maleate

[0032] 1. Raw material preparation: Use p-chlorophenylacetonitrile and 2-bromopyridine as starting materials.

[0033] 2. Generation of intermediate 1: Under the action of sodium amide, the two raw materials react to generate the first intermediate.

[0034] 3. Formation of intermediate 2: Add N,N-dimethylethyl chloride hydrochloride to the reaction solution of the first step to form the second intermediate.

[0035] 4. Generation of chlorpheniramine: The intermediate obtained in the second step is converted into chlorpheniramine under strong alkaline conditions.

[0036] 5. Formation of maleate: Chlorpheniramine is reacted with maleic acid in anhydrous ethanol to obtain the final product, chlorpheniramine maleate.

[0037] Beneficial effects and innovative significance

[0038] The compound medicine of the present invention can not only quickly eliminate acne symptoms through the synergistic effect of Chinese and Western medicines, but also regulate endocrine from the root, improve skin microenvironment, and reduce acne recurrence. The addition of Chinese medicine ingredients significantly reduces the side effects of Western medicine, improves patient compliance and treatment satisfaction, and is an important innovation in the field of acne treatment. In terms of preparation, high conversion and high purity are achieved, the use of heavy metal catalysts is avoided, and the negative impact of industrial products on the human body is reduced. It has high economic benefits.

[0039] Specific implementation method of the drug

[0040] Implementation: Prepare a topical gel combining Chinese and Western medicine, in which Western medicine ingredients account for 5%, Chinese medicine extracts account for 60%, and other ingredients account for 35%. For details of the specific operation, see the preparation method

[0041] Claims

[0042] 1. A compound medicine for treating acne by combining Chinese and Western medicine, characterized in that it contains Western medicine ingredients and Chinese medicine extracts, wherein the Western medicine ingredients include chlorpheniramine maleate, oryzanol, dexamethasone acetate, vitamin B12 (cobalamin)

[0043] Chinese herbal extracts include artificial musk, pearl, calamine powder, borax, amber, sulfur, and lanolin.

[0044] Other ingredients include calcium bicarbonate, dextrin, sucrose

[0045] 2. The compound medicine according to claim 1, characterized in that it is in the form of external application, and the drug components are mixed in a specific ratio.

[0046] 3. The method for preparing the compound medicine according to claim 1, comprising the steps of extracting Chinese medicine components, mixing Western medicine components, and making the final product through pharmaceutical technology.

[0047] According to this patent, 50 facial patients were sampled for experimental verification, among which 20 patients were aged 10-20, 20 were aged 20-50, and 10 were aged 50-70. They were respectively treated with the above-mentioned product, Zoliqing, topical antibiotics, retinoic acid drugs, oral isotretinoin and other western medicines alone, and no drugs were taken.

[0048] The figure below shows the number of people in three age groups corresponding to the three situations.

[0049]

[0050]

[0051] After applying the topical medication, 11 people aged 15-20 years old had their wounds cleaned within one week, 4 people had their wounds cleaned within two weeks, and all of them had their wounds cleaned successfully within 2 days. In addition, 14 people gave high evaluations on the efficacy of the drug, and the anti-acne effect was very good. After applying the topical medication, 10 people aged 20-35 years old had their wounds cleaned within one week, and all of them had their wounds cleaned successfully after 3 weeks, and 6 people had very good functional evaluations.

[0052] After applying the drug externally in the 35-50 age group, 3 people had their wounds debrided within 1 week, and 3 people had their wounds debrided within 2 weeks. All of them had their wounds debrided successfully within 2 weeks, and 6 people were very satisfied with the comfort of the drug.

[0053] As for the comparison patients who took topical medications, most of them had their wounds debrided within two weeks, a few within three weeks, and a very few after taking doxycycline hydrochloride. This shows that the anti-acne and anti-inflammatory effects of Zuoliqing are better than those of ordinary anti-acne drugs on the market.

[0054] This product not only combines the mechanism of Chinese and Western medicine, promotes the spirit of traditional Chinese medicine inheritance, but also retains the therapeutic effect of medicine. It is very suitable for young people who are under great work pressure at this stage. Compared with current acne-clearing drugs, it has significant advantages, is less dependent on drugs, and has a better therapeutic effect on neurological acne and inflammation.

[0055] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A compound external application gel medicine for treating acne, characterized in that: The medicine contains: -(a) Western medicine ingredients: chlorpheniramine maleate, oryzanol, dexamethasone acetate and vitamin B12 (cobalamin); -(b) Chinese herbal medicine extracts: artificial musk, pearl, calamine powder, borax, amber, sulfur and lanolin; -(c) Other ingredients: calcium bicarbonate, dextrin and sucrose, which are used to adjust the properties and stability of the paste; the Western medicine ingredients and Chinese medicine extracts work synergistically to quickly relieve acne symptoms, regulate the body's balance and reduce recurrence.

2. The compound medicine according to claim 1, characterized in that: The medicine is in the form of gel and is suitable for topical external use on the face. The medicine comprises: 5% by weight of western medicine ingredients, 60% by weight of Chinese medicine extracts, and 35% by weight of other ingredients.

3. The compound medicine according to claim 1, characterized in that: The Chinese medicine extract is purified and concentrated by a water-alcohol solvent, and is mixed with Western medicine ingredients in a specific ratio, and the stability and bioavailability of the drug are ensured through a sophisticated preparation process.

4. The method for preparing the compound medicine according to claim 1, characterized in that: The following steps are involved: -(a) preparing active ingredients of western medicines, in particular, dexamethasone acetate is prepared from dexamethasone through a specific chemical reaction, and chlorpheniramine maleate is obtained through a specific synthetic route; -(b) After the Chinese medicine raw materials are processed, the effective ingredients are extracted and concentrated using a suitable solvent; -(c) mixing the western medicine ingredients and the Chinese medicine extracts in proportion, and adding other ingredients to adjust the viscosity of the paste; -(d) The mixture is heated and refined, then cooled and aseptically packaged in aluminum tubes to ensure the sterility and portability of the final product.

5. The compound medicine according to any one of claims 1 to 4, characterized in that: Through clinical verification, it has demonstrated the effects of rapid debridement, high-efficiency anti-inflammatory and improved patient satisfaction for acne patients of different age groups ranging from 10 to 70 years old, especially in the age group of 15 to 20 years old, with the debridement rate reaching a significant level within one week.

6. The use of the compound medicine according to claims 1 to 5, characterized in that: Used to treat various types of acne caused by endocrine disorders, imbalance of skin microenvironment and other factors, including but not limited to common acne, neurological acne and inflammatory acne, providing a comprehensive treatment plan, reducing dependence on single therapy, and enhancing the safety and effectiveness of treatment.

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