Negative pressure sealing drainage dressing and wound surface treatment device

Abstract

The invention relates to the technical field of medical instruments, and provides a vacuum sealing drainage dressing and a wound surface treatment device.The vacuum sealing drainage dressing comprises a sealing layer and a dressing layer which are sequentially arranged in a stacked mode from top to bottom, and further comprises a drainage assembly; the drainage assembly comprises a sucker and a drainage tube, the sucker is arranged at the adsorption opening of the sealing layer, and the drainage tube is connected to the sucker; the dressing layer is of a porous structure, hole walls are communicated with one another to form a continuous channel, the dressing layer is provided with a flexible plasma patch, the flexible plasma patch is suitable for generating plasma acting on a wound surface, and the flexible plasma patch is provided with through holes communicated with pores. The flexible plasma patch is integrally arranged on the dressing layer, negative pressure drainage and wound sterilization and disinfection combined healing promoting treatment can be achieved, the wound or wound treatment process can be simplified, inconvenience caused by frequent dressing change is reduced, and the faster and better healing effect is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a negative pressure sealing drainage dressing and a wound treatment device. Background Art

[0002] Negative pressure sealing drainage dressing is a wound treatment technology that forms a negative pressure closed cavity by covering biological materials and films, and uses an external drainage tube to attract drainage from the wound. It provides a moist environment for the wound and can fully drain and reduce edema. Generally, negative pressure sealing drainage is divided into intermittent negative pressure drainage and short-term continuous negative pressure drainage according to the condition of the wound.

[0003] A one-time negative pressure drainage can maintain effective negative pressure for 5 to 7 days, and is usually removed or replaced after 7 days. For large areas of exposed bones and tendons, a one-time negative pressure drainage can maintain effective negative pressure for 3 to 4 days. During the dressing period, no other treatment can be performed on the wound, the treatment cycle is longer, and the treatment cost increases. Summary of the invention

[0004] The present invention provides a negative pressure sealed drainage dressing and a wound treatment device to solve the above-mentioned technical defects in the prior art. By integrating a flexible plasma patch in the dressing layer, the wound treatment process can be simplified, and negative pressure drainage and wound sterilization and disinfection combined with healing promotion treatment can be achieved, reducing the inconvenience caused by frequent dressing changes and achieving faster and better healing effects.

[0005] A first aspect of the present invention provides a negative pressure sealing drainage dressing, comprising a sealing layer and a dressing layer stacked in sequence from top to bottom, and a drainage component; The drainage component comprises a suction cup and a drainage tube, the suction cup is arranged at the adsorption port of the sealing layer, and the drainage tube is connected to the suction cup; The dressing layer is a porous structure, and the pore walls are interconnected to form a continuous channel. The dressing layer is provided with a flexible plasma patch, which is suitable for generating plasma acting on the wound surface, and the flexible plasma patch is provided with through holes connected to the pores.

[0006] According to the negative pressure sealing drainage dressing provided by the present invention, the dressing layer comprises a first sub-dressing layer and a second sub-dressing layer which are stacked, and the flexible plasma patch is arranged between the first sub-dressing layer and the second sub-dressing layer; The plasma generated by the flexible plasma patch is suitable for acting on the wound surface through the second sub-dressing layer.

[0007] According to the negative pressure sealing drainage dressing provided by the present invention, an adsorption layer is provided on the second sub-dressing layer, and the adsorption layer is used to absorb exudate from the wound surface; Alternatively, an absorption layer is integrated inside the second sub-dressing layer, and the absorption layer is used to absorb exudate from the wound surface.

[0008] According to the negative pressure sealing drainage dressing provided by the present invention, a drug delivery layer is provided on the second sub-dressing layer, the drug delivery layer is arranged toward the wound surface, and the drug delivery layer is coated with drugs or pre-loaded with biodegradable drug microcapsules.

[0009] According to the negative pressure sealing drainage dressing provided by the present invention, the second sub-dressing layer is integrated with a detection layer, the detection layer is provided with a flexible circuit board, and the flexible circuit board is provided with at least one of a temperature and humidity sensor, an oxygen sensor, a pH sensor and a biometric sensor.

[0010] According to the negative pressure sealing drainage dressing provided by the present invention, a signal isolation layer is provided on the outer side of the detection layer to isolate electromagnetic interference or discharge interference of the flexible plasma patch.

[0011] According to the negative pressure sealing drainage dressing provided by the present invention, the outer side of the detection layer is wrapped with a biological barrier coating, and the biological barrier coating is used to protect the flexible circuit board and each sensor arranged on the flexible circuit board.

[0012] According to the negative pressure sealing drainage dressing provided by the present invention, the flexible plasma patch comprises a first dielectric barrier layer, an electrode layer and a second dielectric barrier layer stacked in sequence from top to bottom, and the electrode layer is suitable for connecting a power module; The first dielectric barrier layer is provided with first through holes at intervals, and the first through holes are arranged corresponding to the gaps of the electrode layer; the second dielectric barrier layer is provided with second through holes at intervals, and the positions of the second through holes correspond to the positions of the first through holes, and the first through holes, the gaps of the electrode layer and the second through holes constitute the through holes.

[0013] According to the negative pressure sealing drainage dressing provided by the present invention, the electrode layer includes a substrate, a positive electrode and a negative electrode, the positive electrode and the negative electrode are coplanarly arranged on the substrate, and the positive electrode and the negative electrode are both suitable for connecting to a power module.

[0014] The second aspect of the present invention provides a wound treatment device, comprising a negative pressure device, a power module and any one of the negative pressure sealing drainage dressings, wherein the negative pressure device is suitable for providing negative pressure to the negative pressure sealing drainage dressing, and the power module is electrically connected to the flexible plasma patch of the negative pressure sealing drainage dressing.

[0015] The negative pressure sealing drainage dressing provided by the present invention integrates a flexible plasma patch in the dressing layer, and the flexible plasma patch can adapt to the bending of the wound surface during negative pressure suction with the dressing layer, and the flexible plasma patch is provided with a through hole. When the negative pressure sealing drainage dressing is performing negative pressure suction, the wound exudate passes through the pores of the dressing layer and the through holes of the flexible plasma patch, enters the drainage tube to complete the negative pressure drainage treatment; when the negative pressure sealing drainage dressing is not performing negative pressure suction, the dressing layer or part of the dressing layer supports the flexible plasma patch, and there is no need to additionally set up a gasket or other structure, so that there is a fixed air gap between the flexible plasma patch and the wound surface for the working gas to flow in. When the negative pressure sealing drainage dressing is used for plasma therapy, the flexible plasma patch generates microplasma on the side close to the wound, and its active particles and other components penetrate the dressing layer to reach the wound to exert a bactericidal effect, thereby achieving therapeutic effects such as promoting tissue regeneration. In addition, liquid is input through the flushing tube, or the exudative wound and the dressing layer itself can form a moist environment. Active particles such as active nitrogen oxides can react with water to form plasma-activated water, which contains unique active substances such as hydroxide and hydrogen peroxide, which can further enhance the bactericidal effect on the wound.

[0016] In other words, the negative pressure sealed drainage dressing provided in the embodiment of the present invention can simplify the wound treatment process by integrating a flexible plasma patch in the dressing layer, realize negative pressure drainage and wound sterilization and disinfection combined with healing promotion treatment, reduce the inconvenience caused by frequent dressing changes, and achieve faster and better healing effects.

[0017] The wound treatment device provided by the present invention has all the above advantages because it includes the above negative pressure sealing drainage dressing. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0019] Figure 1 It is a schematic diagram of the structure of a negative pressure sealing drainage dressing provided in an embodiment of the present invention.

[0020] Figure 2 It is one of the structural schematic diagrams of the second sub-dressing layer in the negative pressure sealing drainage dressing provided in an embodiment of the present invention.

[0021] Figure 3 This is the second structural schematic diagram of the second sub-dressing layer in the negative pressure sealing drainage dressing provided in an embodiment of the present invention.

[0022] Figure 4It is a schematic diagram of the structure of a flexible plasma patch in a negative pressure sealing drainage dressing provided in an embodiment of the present invention.

[0023] Figure 5 yes Figure 4 A top view of the flexible plasmonic patch is shown.

[0024] Figure 6 yes Figure 4 Schematic diagram of the structural breakdown of the flexible plasma patch shown.

[0025] Reference numerals: 100, sealing layer; 200, dressing layer; 210, first sub-dressing layer; 220, second sub-dressing layer; 221, adsorption layer; 222, drug delivery layer; 300, flexible plasma patch; 310, first dielectric barrier layer; 311, first through hole; 320, electrode layer; 321, positive electrode; 322, negative electrode; 330, second dielectric barrier layer; 331, second through hole; 340, through hole; 350, adapter; 400, drainage assembly; 410, suction cup; 420, drainage tube. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be clearly and completely described below in conjunction with the drawings of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] In the description of the embodiments of the present application, it should be noted that, unless otherwise clearly specified and limited, the terms "connected" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms in the embodiments of the present application can be understood according to specific circumstances.

[0028] In the embodiments of the present application, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being "above", "above" or "above" a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being "below", "below" or "below" a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0029] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the embodiments of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, without contradiction.

[0030] Figure 1 It is a schematic diagram of the structure of the negative pressure sealing drainage dressing provided in an embodiment of the present invention.

[0031] See also Figure 1 The embodiment of the present invention provides a negative pressure sealing drainage dressing, which effectively removes the wound surface and the exudate in the wound by creating a local negative pressure environment, and promotes the healing of the wound tissue. The negative pressure sealing drainage dressing includes a sealing layer 100 and a dressing layer 200 stacked in sequence from top to bottom, and a drainage component 400.

[0032] The drainage assembly 400 includes a suction cup 410 and a drainage tube 420. The suction cup 410 is provided at the suction port of the sealing layer 100, that is, a hollow suction port is provided near the center of the sealing layer 100. The suction cup 410 completely covers the suction port and is bonded and fixed to the sealing layer 100. The drainage tube 420 is connected to the suction cup 410. Compared with the adsorption method of embedding the drainage tube 420 in the dressing layer 200, the adsorption method of the suction cup 410 has a more uniform pressure distribution on the tissue. The adsorption of the suction cup 410 no longer relies on complex positioning and fixation, which shortens the preparation time and reduces the technical difficulty.

[0033] The dressing layer 200 has a porous structure, and the pore walls are interconnected to form a continuous channel. The dressing layer 200 is provided with a flexible plasma patch 300, which is suitable for generating plasma to act on the wound surface. The flexible plasma patch 300 is provided with a through hole 340 along the thickness direction, and the through hole 340 is connected to the pores of the dressing layer 200.

[0034] The size of the sealing layer 100 is larger than that of the dressing layer 200, and the size of the dressing layer 200 can be larger than that of the flexible plasma patch 300. The sealing layer 100 is attached to the outer surface of the dressing layer 200 and the skin around the wound surface, so that the negative pressure sealing drainage dressing and the wound surface form a closed space to maintain a negative pressure environment, ensure a continuous and stable negative pressure state, promote blood flow, and accelerate tissue repair. The sealing layer 100 is also used to prevent bacteria, dust and other pollutants from invading the wound, reduce the risk of infection, and allow moderate exchange of oxygen and carbon dioxide to support cell metabolism without completely blocking air circulation.

[0035] The sealing layer 100 can be made of medical grade silicone or elastic polymer, which has good flexibility and good air permeability, and can closely fit various wound shapes. The sealing layer 100 is self-adhesive, does not require additional bandages, and is easy to apply and remove quickly.

[0036] The dressing layer 200 may be a sponge or a foam. The dressing layer 200 absorbs and guides wound secretions to flow toward the drainage tube 420, while providing a certain amount of support to relieve local pressure. The sponge may be a porous sponge. The porous sponge is made of a medical-grade hydrophilic material and has good permeability. It can absorb excessive exudate, keep the wound dry and clean, and provide a moist healing environment. The foam may be a polyurethane foam, which is soft and has a high porosity and can adapt to a variety of wound shapes.

[0037] The flexible plasma patch 300 is highly flexible and can fit tightly to irregular wounds and wound surfaces. The flexible plasma patch 300 is an integrated micro plasma generator attached to a porous sponge. It generates low-temperature plasma by exciting the working gas (air or inert gas) through high-frequency alternating current. It has the functions of sterilization, anti-inflammatory, and wound healing. In addition, the bactericidal and disinfecting properties of the plasma itself can continuously fight bacteria and other pathogens, reduce the chance of secondary infection, and make it possible to wear it for a long time without immediate replacement without causing the wound to deteriorate. The flexible plasma patch is set inside the dressing, and plasma wound treatment and negative pressure drainage can be performed sequentially in situ, without the need to repeatedly change the dressing, to ensure the consistency and effectiveness of the therapeutic effect.

[0038] During use, after the wound surface is treated, the porous sponge can be used as a dressing layer 200 to gently cover the wound surface, ensuring that the entire injured area is completely wrapped without leaving gaps, and the flexible plasma patch 300 is spread on the porous sponge, or clamped inside the porous sponge, and the position of the flexible plasma patch 300 is adjusted so that the electrode of the flexible plasma patch 300 is aligned with the main lesion, ensuring that the flexible plasma patch 300 is flat and wrinkle-free. A medical film is used as a sealing layer 100 to be pasted on the outer surface of the dressing layer 200 and the skin around the wound surface, and a circular hole is cut in the center of the medical film, and the suction cup 410 is completely covered and pasted on the circular hole of the medical film, and the suction cup 410 is fixed. One end of the drainage hose is sealed and connected to the suction cup 410, and the other end is connected to the negative pressure source to establish a continuous negative pressure environment, assist in extracting excess fluid, promote blood circulation and tissue regeneration. The power supply of the flexible plasma patch 300 is turned on, and appropriate parameters are set to start plasma sterilization and promote healing.

[0039] In order to improve the sealing of the negative pressure closure drainage dressing, sealing stickers or special adhesives can also be used to fix the edges to create a closed chamber.

[0040] Equivalently, the negative pressure sealed drainage dressing provided in the embodiment of the present invention can simplify the wound treatment process by integrating the flexible plasma patch 300 in the dressing layer 200, realize the combined treatment of negative pressure drainage and wound sterilization and disinfection, reduce the inconvenience caused by frequent dressing changes, and achieve faster and better healing effects.

[0041] It can be understood that the negative pressure sealing drainage dressing provided by the embodiment of the present invention, by integrating the flexible plasma patch 300 in the dressing layer 200, the flexible plasma patch 300 can adapt to the bending of the wound surface with the dressing layer 200 during negative pressure suction, and the flexible plasma patch 300 is provided with a through hole 340. When the negative pressure sealing drainage dressing is performing negative pressure suction, the wound exudate passes through the pores of the dressing layer 200 and the through hole 340 of the flexible plasma patch 300, enters the drainage tube 420 to complete the negative pressure drainage treatment; when the negative pressure sealing drainage dressing is not performing negative pressure suction, the dressing layer 200 or part of the dressing layer 200 supports the flexible plasma patch 300, and there is no need to set up additional structures such as gaskets, so that there is a fixed air gap between the flexible plasma patch 300 and the wound surface for the working gas to flow in. When the negative pressure sealing drainage dressing is used for plasma therapy, the flexible plasma patch 300 generates micro plasma on the side close to the wound surface, and its active particles and other components penetrate the dressing layer 200 to reach the wound surface to exert a bactericidal effect, thereby achieving therapeutic effects such as promoting tissue regeneration.

[0042] In addition, liquid is input through the flushing tube, or the exudative wound and the dressing layer 200 form a moist environment, and active particles such as active nitrogen oxides react with water to form plasma-activated water, which contains unique active substances such as hydroxide and hydrogen peroxide, which can further enhance the wound sterilization effect.

[0043] Continue reading Figure 1 In some embodiments of the present invention, the dressing layer 200 includes a first sub-dressing layer 210 and a second sub-dressing layer 220 which are stacked, and the flexible plasma patch 300 is arranged between the first sub-dressing layer 210 and the second sub-dressing layer 220; the plasma generated by the flexible plasma patch 300 is suitable for acting on the wound surface through the second sub-dressing layer 220.

[0044] This is equivalent to providing sub-dressing layers 200 composed of porous sponges on the upper and lower layers of the flexible plasma patch 300, that is, the first sub-dressing layer 210 and the second sub-dressing layer 220 are both porous structures, and the lower second sub-dressing layer 220 can not only be filled into the wound cavity to ensure full contact with the bottom without excessive pressure to avoid obstruction of blood flow, but also can provide good support for the flexible plasma patch 300, so that a fixed gap is formed between the flexible plasma patch 300 and the wound surface, thereby ensuring the entry of the working gas of the flexible plasma patch 300.

[0045] Moreover, the exudative wound surface and the second sub-dressing layer 220 below form a moist environment. During plasma therapy, the negative pressure sealed drainage dressing can generate ion-activated water at the wound surface, which contains unique active substances such as hydroxide and hydrogen peroxide, further enhancing the sterilization effect on the wound surface.

[0046] Figure 2 It is one of the structural schematic diagrams of the second sub-dressing layer 220 in the negative pressure sealing drainage dressing provided in an embodiment of the present invention.

[0047] See also Figure 2 In some embodiments of the present invention, an absorption layer 221 is provided on the second sub-dressing layer 220, and the absorption layer 221 is used to absorb exudate from the wound surface; or, an absorption layer 221 is integrated inside the second sub-dressing layer 220, and the absorption layer 221 is used to absorb exudate from the wound surface.

[0048] This is equivalent to setting an adsorption layer 221 on the surface or inside of the second sub-dressing layer 220. The adsorption layer 221 can be set at the location of hypertonic fluid according to the wound surface conditions to enhance the liquid absorption capacity of the negative pressure sealing drainage dressing and avoid local hypoxia caused by excessive soaking of the sponge (second sub-dressing layer 220).

[0049] Among them, the adsorption layer 221 is composed of highly hygroscopic components such as calcium alginate and sodium carboxymethyl cellulose. For example, calcium alginate and sodium carboxymethyl cellulose can be mixed in a sponge, or a sponge can be independently set as a carrier and mixed with highly hygroscopic components such as calcium alginate and sodium carboxymethyl cellulose.

[0050] Figure 3 This is the second structural schematic diagram of the second sub-dressing layer 220 in the negative pressure sealing drainage dressing provided in an embodiment of the present invention.

[0051] See also Figure 3 In some embodiments of the present invention, a drug delivery layer 222 is provided on the second sub-dressing layer 220, and the drug delivery layer 222 is arranged toward the wound surface. The drug delivery layer 222 is coated with drugs or pre-loaded with biodegradable drug microcapsules.

[0052] Since the plasma released by the flexible plasma patch 300 has the effects of sterilization, cell activation, and accelerated tissue repair in wound treatment, in the case of a large amount of pus or severe infection, the use of plasma alone may not be sufficient to deal with the problem of bacterial reproduction. In this case, the combined drug delivery layer 222 is used to treat the wound surface, which can achieve better treatment effects and significantly improve the healing rate of complex wounds.

[0053] This is equivalent to using plasma and drugs to synergistically treat wounds, further improving the wound treatment effect and shortening the wound treatment cycle. Since plasma can destroy the outer membrane of pathogens, drugs can more easily enter the pathogens, achieving good treatment effects. At the same time, drugs make up for the limitation that plasma cannot solve deep infections.

[0054] By designing the drug formulation and plasma release parameters, it is possible not only to promote the resolution of wound inflammation, but also to activate the self-healing mechanism, thereby reducing the treatment cycle and the occurrence of subsequent complications.

[0055] The drug delivery layer 222 can preload the drug in the biodegradable polymer and slowly release it over time to achieve the purpose of long-term concentration control. The drug delivery layer 222 can also use active carriers such as liposomes, microcapsules, and nanoparticles to carry the drug to enhance penetration and targeting.

[0056] The drugs carried by the drug delivery layer 222 can be selected according to the condition of the wound surface, such as antibiotics, growth factors, guaiacol, etc.

[0057] In some embodiments of the present invention, the second sub-dressing layer 220 is integrated with a detection layer, the detection layer is provided with a flexible circuit board, and the flexible circuit board is provided with at least one of a temperature and humidity sensor, an oxygen sensor, a pH sensor and a biometric sensor.

[0058] That is, according to the condition of the wound, any one of the temperature and humidity sensors, oxygen sensors, pH sensors and biometric sensors can be set on the flexible circuit board; according to the condition of the wound, any two or any three of the temperature and humidity sensors, oxygen sensors, pH sensors and biometric sensors can be set on the flexible circuit board; according to the condition of the wound, any temperature and humidity sensors, oxygen sensors, pH sensors and biometric sensors can be set on the flexible circuit board.

[0059] Among them, the temperature and humidity sensors are used to monitor the temperature and humidity near the wound surface. When the temperature and humidity near the wound surface are too high or too low, the dressing permeability or humidification is adjusted in time to prevent infection or dryness.

[0060] Oxygen sensors use oxygen-sensitive membranes, such as zinc oxide, palladium and other materials, to monitor oxygen tension in tissues (i.e., local tissue oxygen partial pressure) in real time. Because the normal metabolism and regeneration process of human tissues require adequate oxygen supply. Oxygen is involved in multiple links such as energy generation, enzyme activity regulation, and immune cell function, and is especially important for angiogenesis and collagen synthesis. Therefore, monitoring oxygen tension can intuitively reflect the blood flow conditions and physiological stress levels at the wound. By analyzing oxygen tension fluctuations, local hypoxia can be detected early, indicating possible blood circulation disorders, aggravated infection or other complications. Continuous monitoring helps to grasp the effectiveness of therapeutic interventions and adjust treatment plans in a timely manner, such as adjusting negative pressure drainage parameters or drug dosages.

[0061] The pH sensor is used to measure the pH value near the wound surface, reflecting the health of the wound environment and supporting the indirect assessment of the bacterial survival status.

[0062] Biometric sensors can detect the presence of inflammation-related biomarkers such as interleukins and C-reactive proteins, providing early indications of infection risks.

[0063] In some embodiments of the present invention, a signal isolation layer is provided on the outer side of the detection layer, and the isolation layer is used to isolate electromagnetic interference or discharge interference of the flexible plasma patch 300 .

[0064] By setting up a signal isolation layer, it can be ensured that the signals of each sensor are clear, unaffected by electromagnetic interference or plasma discharge in the body, and thus maintain accuracy and stability.

[0065] In some embodiments of the present invention, the outer side of the detection layer is wrapped with a biological barrier coating, and the biological barrier coating is used to protect the flexible circuit board and each sensor arranged on the flexible circuit board.

[0066] By providing a biological barrier coating, each sensor can be protected from corrosion by body fluids and the service life of each sensor can be extended. The biological barrier coating uses an inert polymer to reduce immune rejection reactions.

[0067] Figure 4 Schematic diagram of the structure of the flexible plasma patch 300 in the negative pressure sealing drainage dressing provided in an embodiment of the present invention. Figure 5 yes Figure 4 A top view of the flexible plasma patch 300 is shown. Figure 6 yes Figure 4 The flexible plasma patch 300 is shown as a schematic diagram of structural decomposition.

[0068] See also Figures 4 to 6 In some embodiments of the present invention, the flexible plasma patch 300 includes a first dielectric barrier layer 310, an electrode layer 320, and a second dielectric barrier layer 330 stacked in sequence from top to bottom, and the electrode layer 320 is suitable for connecting a power module to generate plasma.

[0069] The first dielectric barrier layer 310 is provided with first through holes 311 at intervals, and the first through holes 311 are arranged corresponding to the gaps of the electrode layer 320; the second dielectric barrier layer 330 is provided with second through holes 331 at intervals, and the positions of the second through holes 331 correspond to the positions of the first through holes 311, and the positions of the first through holes 311 and the second through holes 331 both correspond to the positions of the pores.

[0070] In other words, the through hole 340 of the flexible plasma patch 300 is composed of the first through hole 311 , the second through hole 331 and the gap provided in the electrode layer 320 . The positions of the first through hole 311 , the second through hole 331 and the gap correspond to each other and are interconnected.

[0071] With this arrangement, when the negative pressure sealing drainage dressing is performing negative pressure suction, the wound exudate passes through the pores of the dressing layer 200, the second through hole 331 of the flexible plasma patch 300, the gap between the electrode layer 320 and the first through hole 311, and enters the drainage tube 400 to complete the negative pressure drainage treatment.

[0072] Continue reading Figure 5 and Figure 6 In some embodiments of the present invention, the electrode layer 320 includes a positive electrode 321, an insulating dielectric layer and a negative electrode 322 stacked in sequence from top to bottom. The positive electrode 21, the insulating dielectric layer and the negative electrode 22 are stacked to form a dielectric barrier discharge similar to a "sandwich" structure.

[0073] Dielectric barrier discharge (DBD discharge) does not require the electrode to directly contact the gas. Instead, it uses an insulating medium to isolate the electrode and the gas, which can prevent electrode corrosion and extend the life of the equipment.

[0074] In some embodiments of the present invention, the electrode layer 320 includes a substrate, a positive electrode 321 and a negative electrode 322 , wherein the positive electrode 321 and the negative electrode 322 are coplanarly disposed on the substrate, and both the positive electrode 321 and the negative electrode 322 are suitable for connecting to a power module.

[0075] Compared with other discharge methods, the flexible plasma patch 300 uses coplanar electrodes to achieve stable and consistent energy transfer over a wider range, avoiding the formation of hot spots and ensuring uniform heating of the treatment area. It is conducive to the generation of a large number of reactive oxygen species (ROS), reactive nitrogen species (RNS) and other charged particles, effectively promoting biological effects such as wound healing, anti-inflammatory and analgesia.

[0076] It should be noted that the discharge electrode is not limited to a comb-teeth electrode, a spiral electrode, a mesh electrode, or a honeycomb electrode.

[0077] The grid-like electrode is usually composed of a series of interwoven metal wires or strips, which alternately serve as positive and negative electrodes to form multiple intersections and gaps. When the external power module applies the potential to the positive and negative electrodes 322, respectively, a strong electric field is established in the gaps of the grid. Under the action of the electric field, the electrons in the gas molecules are pulled and begin to separate from the atoms or molecules to form free electrons. The free electrons are accelerated by the electric field and collide with more gas molecules to form new electron-ion pairs. As the electron density continues to increase, the local electric field becomes extremely strong, enough to completely break down the gas medium to form a discharge. The discharge path spreads along the gaps of the grid to form a large number of dispersed but connected small discharge channels, which increases the effective area covered by the plasma. In the discharge channel, a large number of electrons, positive ions and excited molecules gather to form a dense plasma cloud. The generated plasma diffuses from the discharge channel to achieve the sterilization and disinfection function of the plasma.

[0078] The honeycomb electrode generally includes a set of central electrodes (usually positive electrodes) and an annular or hexagonal negative electrode 322 surrounding it. The gap in the middle is filled with gas medium. When the high-voltage power supply applies voltage between the central electrode and the peripheral electrode, a non-uniform electric field is formed between the two. Due to the unique arrangement of the electrodes, the electric field is very concentrated inside each unit of the honeycomb, especially near the central electrode, forming a highly concentrated electric field gradient. The central electrode attracts free electrons and other charged particles in the surrounding space to move toward it. At the same time, the negative electrode 322 repels these charged particles, causing charges to accumulate around the central electrode. When the electric field strength is large enough, it causes the gas medium to be ionized to form charge carriers (electrons and positive ions). The medium after breakdown forms a discharge channel. The high-energy particles in the discharge channel continue to interact with other molecules to form a large number of ions, electrons and active species, namely plasma. The plasma is not only confined to the discharge channel, but will spread to the target area to sterilize and disinfect the target area.

[0079] When a high voltage AC or DC voltage is applied between the comb-shaped electrode (positive electrode) and the ground (or negative electrode), a strong electric field will be formed between the electrodes. When the electric field strength exceeds the breakdown electric field of the gas molecules (about 10^6 V / m), the molecules in the air of the target area will be strongly ionized and decomposed into charged particles (electrons, positive ions and free radicals). The charged particles move faster under the action of the electric field, collide with other neutral molecules, and further produce more charged particles, forming an avalanche-like chain reaction. As the electron density increases, the local current increases sharply, forming a discharge channel. The high temperature and high-energy electrons in the discharge channel cause the gas molecules to be completely ionized, forming a plasma composed of ions, electrons and excited molecules. The plasma propagates outward from the discharge area through electrodynamics and thermal diffusion, and efficiently sterilizes the target area to achieve the purpose of treatment.

[0080] Among them, the edge or tip of the comb-tooth electrode has a small radius of curvature, and the electric field strength is greatly enhanced, which can lead to electric field concentration. In other words, the sharp tip of the comb-tooth electrode can locally amplify the electric field, reducing the voltage required for discharge, so that plasma discharge can be achieved at a lower energy input, thereby reducing thermal damage to surrounding tissues. In addition, the multi-tooth arrangement can form a dense discharge lattice, achieving uniform coverage over a larger area, which is suitable for scenarios such as large-area wound treatment or surface processing.

[0081] When the spiral discharge electrode provides high voltage electricity, it will generate an electromagnetic field in a spiral direction. Under the combined action of the strong magnetic field and electric field, the gas molecules are ionized, and the electrons are stripped from the atoms to form electrons and ions. The structure of the spiral electrode guides the electrons and ions to move along the spiral path. The charge accumulation on the spiral path triggers discharge. During the discharge process, the gas molecules are transformed into a plasma state due to ionization and heating, forming a stable plasma cloud. The plasma cloud is affected by the spiral magnetic field and propels along the spiral axis, showing a spiral or vortex motion.

[0082] Among the above-mentioned electrodes, the fine tooth edges of the comb-tooth electrode can focus the electric field, which is suitable for the treatment of local lesions, with less damage to normal tissues around the wound, suitable for the treatment of deep skin infections, and can effectively kill bacteria without damaging healthy tissues. Since the honeycomb electrode can provide a more uniform discharge distribution and a wide plasma coverage area, it is suitable for the treatment of larger sinus tracts. Since the grid electrode has strong permeability, it is suitable for treatment deep inside the tissue or in complex morphological areas, which is conducive to the treatment that needs to penetrate into the deep tissue and can achieve deep purification and repair. Since the spiral electrode uses the spiral discharge characteristics and directional plasma flow, it can form a directional treatment effect in deep tissues. The ability to deliver plasma in a directional manner enhances the accuracy and safety of treatment and is suitable for targeted treatment.

[0083] Continue reading Figure 3 and Figure 4 In some embodiments of the present invention, the flexible plasma patch 300 further includes a transition component 350, the transition component 350 is integrally connected with the electrode line of the electrode layer 320, and the transition component 350 is suitable for connecting to a power module.

[0084] The flexible plasma patch 300 is conveniently connected to the power module by providing the adapter component 350. The adapter component 350 can be provided with a standardized plug and socket, allowing the flexible plasma patch 300 to quickly access the power module, which is convenient for maintenance and connection.

[0085] The present invention also provides a wound treatment device, which includes a negative pressure device, a power module and any one of the negative pressure sealing drainage dressings. The negative pressure device is suitable for providing negative pressure to the negative pressure sealing drainage dressing, and the power module is electrically connected to the flexible plasma patch 300 of the negative pressure sealing drainage dressing.

[0086] During the use of the wound treatment device, first thoroughly clean the wound and surrounding skin, remove grease and foreign matter, and create a sterile environment; then cut the sealing layer 100 so that the size of the sealing layer 100 is larger than the area of ​​the wound, and ensure that the edges of the sealing layer 100 have sufficient overlapping area. Place the negative pressure closed drainage dressing with the flexible plasma patch 300, press along the edge with your fingers, so that the sealing layer 100 fits tightly to the skin to form a seamless barrier. Use the palm of your hand to pat to check whether the sealing layer 100 is firm and there is no sign of looseness, and at the same time confirm that the negative pressure device (negative pressure pump) is connected correctly and the power module is connected normally.

[0087] When the negative pressure device is turned on for negative pressure suction, the wound exudate passes through the pores of the dressing layer 200 and the through hole 340 of the flexible plasma patch 300, and enters the drainage tube 400 to complete the negative pressure drainage treatment. When the negative pressure suction is stopped, the dressing layer 200 or part of the dressing layer 200 supports the flexible plasma patch 300, and there is no need to set up additional structures such as gaskets, so that there is a fixed air gap between the flexible plasma patch 300 and the wound surface for the working gas to flow in.

[0088] When the negative pressure sealing drainage dressing is used for plasma therapy, the flexible plasma patch 300 generates micro plasma on the side close to the wound surface, and sterilizes by generating active nitrogen oxides, active particles, ultraviolet rays and other substances. The active particles and other components reach the wound surface through the through holes of the dressing layer 200 to exert a sterilizing effect, thereby achieving therapeutic effects such as promoting tissue regeneration. In addition, the exudative wound surface and the dressing layer 200 form a moist environment, and active particles such as active nitrogen oxides react with water to form plasma-activated water, which contains unique active substances such as hydroxide and hydrogen peroxide, and can further enhance the sterilization effect of the wound surface.

[0089] In the wound treatment device provided by the embodiment of the present invention, the negative pressure sealing drainage dressing is integrated with a flexible plasma patch 300. The plasma is rich in high-energy particles and free radicals, which can directly destroy the cell membrane and DNA of bacteria to achieve antibacterial effects, that is, coupled plasma technology, which can effectively deal with multi-drug resistant strains, reduce the infection rate, and create a purer healing environment for the wound. The active substances in the plasma (such as ROS, RNS) can not only eliminate pathogens, but also stimulate cell metabolism, promote the release of growth factors, accelerate angiogenesis and epithelial cell migration, and thus speed up tissue repair. Compared with the traditional negative pressure sealing drainage (VSD) technology, it is difficult to achieve the same effect by relying solely on negative pressure drainage.

[0090] In addition, plasma can adjust the pH value, maintain a suitable redox state, and optimize tissue regeneration conditions. At the same time, plasma has antibacterial properties and can continue to work even in a closed state, reducing the chance of cross-contamination caused by repeated changes of dressings. Therefore, it is possible to achieve sequential treatment of negative pressure drainage and wound sterilization and disinfection to promote healing without changing dressings.

[0091] Plasma therapy can help regulate the level of inflammatory factors, reduce fibrin deposition, and guide the correct arrangement of collagen fibers. Combined with the mechanical stretching effect of negative pressure closed drainage (VSD) technology, it can reduce scar area and improve healing quality.

[0092] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A negative pressure sealing drainage dressing, characterized in that: It includes a sealing layer and a dressing layer stacked in sequence from top to bottom, and a drainage component; The drainage component comprises a suction cup and a drainage tube, the suction cup is arranged at the adsorption port of the sealing layer, and the drainage tube is connected to the suction cup; The dressing layer is a porous structure, and the pore walls are interconnected to form a continuous channel. The dressing layer is provided with a flexible plasma patch, which is suitable for generating plasma acting on the wound surface, and the flexible plasma patch is provided with through holes connected to the pores.

2. The negative pressure sealing drainage dressing according to claim 1, characterized in that: The dressing layer comprises a first sub-dressing layer and a second sub-dressing layer which are stacked, and the flexible plasma patch is arranged between the first sub-dressing layer and the second sub-dressing layer; The plasma generated by the flexible plasma patch is suitable for acting on the wound surface through the second sub-dressing layer.

3. The negative pressure sealing drainage dressing according to claim 2, characterized in that: An adsorption layer is provided on the second dressing layer, and the adsorption layer is used to absorb exudate from the wound surface; Alternatively, an absorption layer is integrated inside the second sub-dressing layer, and the absorption layer is used to absorb exudate from the wound surface.

4. The negative pressure sealing drainage dressing according to claim 2, characterized in that: A drug delivery layer is arranged on the second sub-dressing layer, and the drug delivery layer is arranged toward the wound surface. The drug delivery layer is coated with drugs or pre-loaded with biodegradable drug microcapsules.

5. The negative pressure sealing drainage dressing according to claim 2, characterized in that: The second sub-dressing layer is integrated with a detection layer, the detection layer is provided with a flexible circuit board, and the flexible circuit board is provided with at least one of a temperature and humidity sensor, an oxygen sensor, a pH sensor and a biometric sensor.

6. The negative pressure sealing drainage dressing according to claim 5, characterized in that: The outer side of the detection layer is wrapped with a signal isolation layer for isolating electromagnetic interference or discharge interference of the flexible plasma patch.

7. The negative pressure sealing drainage dressing according to claim 5, characterized in that: The outer side of the detection layer is wrapped with a biological barrier coating, and the biological barrier coating is used to protect the flexible circuit board and each sensor arranged on the flexible circuit board.

8. The negative pressure sealing drainage dressing according to any one of claims 1 to 7, characterized in that: The flexible plasma patch comprises a first dielectric barrier layer, an electrode layer and a second dielectric barrier layer stacked in sequence from top to bottom, wherein the electrode layer is suitable for connecting to a power module; The first dielectric barrier layer is provided with first through holes at intervals, and the first through holes are arranged corresponding to the gaps of the electrode layer; the second dielectric barrier layer is provided with second through holes at intervals, and the positions of the second through holes correspond to the positions of the first through holes, and the first through holes, the gaps of the electrode layer and the second through holes constitute the through holes.

9. The negative pressure sealing drainage dressing according to claim 8, characterized in that: The electrode layer comprises a substrate, a positive electrode and a negative electrode. The positive electrode and the negative electrode are coplanarly arranged on the substrate. Both the positive electrode and the negative electrode are suitable for connecting to a power module.

10. A wound treatment device, characterized in that: It comprises a negative pressure device, a power module and the negative pressure sealing drainage dressing according to any one of claims 1 to 9, wherein the negative pressure device is suitable for providing negative pressure to the negative pressure sealing drainage dressing, and the power module is electrically connected to the flexible plasma patch of the negative pressure sealing drainage dressing.

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