Preparation method of oxilafluorine
Olaflu was successfully prepared through a four-step reaction process, which solved the problems of long reaction routes, difficult separation and purification, low yield and use of highly toxic raw materials in the existing Olafluorine synthesis method, and achieved high purity and high yield preparation, which was suitable for industrial production.
Patent Information
- Application Number
- CN202411561565.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-04
- Publication Date
- 2025-03-21
AI Technical Summary
The existing olafluoride synthesis method has problems such as long reaction routes, difficult separation and purification, low yields, and poor use of raw materials with highly toxic and stable stability, and is not suitable for industrial production.
A four-step reaction process is adopted: compound (II) reacts with octadecamine to form compound (III), then deprotection forms compound (IV), then hydroxyethylated to form compound (V), and finally reacts with hydrogen fluoride to form olafluoride (I). The raw materials used in this method are cheap and easy to obtain, safe, with high reaction selectivity, and are suitable for industrial production.
It realizes high purity and high yield preparation of olafluor, with simple process operation, environmentally friendly, and suitable for industrial production.