Hygienic insecticidal composition and application thereof

Abstract

The invention relates to a sanitary insecticide, in particular to a sanitary insecticidal composition (tolfenpyrad and propoxur) and application thereof. The composition comprises the tetratolfenpyrad and the propoxur, and the weight ratio of the tetratolfenpyrad to the propoxur is (15: 1)-(1: 9). The dosage form of the sanitary insecticidal composition is a suspending agent, an oil suspending agent, a dry suspending agent, wettable powder and water dispersible granules. According to the sanitary insecticidal composition disclosed by the invention, two insecticides with different action mechanisms are compounded for use, cross resistance does not exist, the control effect is improved, in addition, the drug resistance of pests is delayed, and resistance treatment of the pests is facilitated.

Description

Technical Field

[0001] The invention relates to a sanitary insecticide, in particular to a sanitary insecticide composition (tetrazolyl pyraclostrobin and propoxur) and application thereof. Background Art

[0002] In recent years, diamide insecticides have developed rapidly and have become the third largest category of insecticides after neonicotinoids and pyrethroids. Diamide insecticides have a unique mechanism of action, which can act on the nicotinic acid receptors in insects, making them activated for a long time, resulting in excessive release of intracellular calcium ions. Excess calcium ions can bind to troponin in insect muscle cells, causing the insect muscles to contract and eventually paralyze and die.

[0003] However, long-term use of the drug alone may lead to resistance, and therefore a suitable compound composition needs to be selected to improve the efficacy and reduce the dosage. Summary of the invention

[0004] The technical problem to be solved by the present invention is to provide a sanitary insecticide composition (tetrazolyl pyrifos and propoxur) and its application in view of the deficiencies in the prior art.

[0005] In order to achieve the above object, the present invention adopts the following technical solution:

[0006] A sanitary insecticide composition comprises tetrazobactam and propoxur, wherein the weight ratio of tetrazobactam to propoxur is 15:1-1:9.

[0007] An application of the sanitary insecticide composition, wherein the sanitary insecticide composition is used to control sanitary pests in places where sanitary pests are present.

[0008] The sanitary pests are one or more of mosquitoes, flies, fleas, ants, cockroaches, mites, wasps and bedbugs; and the places where the sanitary pests appear are hotels, airplanes, schools, factories, family residences or livestock habitats.

[0009] A sanitary insecticide preparation comprises active ingredients and adjuvants. The active ingredient in the preparation is the composition, and the composition accounts for 2% to 50% of the total weight of the insecticide group.

[0010] The preparation dosage forms are suspension concentrate, oil suspension concentrate, dry suspension concentrate, wettable powder and water dispersible granules.

[0011] The auxiliary agent in the preparation is any one or more of a dispersant, a wetting agent, a disintegrant, a filler, an antifreeze agent, a thickener, a preservative, a defoamer, a solvent, an emulsifier, an encapsulating material, an organic amine and deionized water.

[0012] The auxiliary agent also contains a raw drug adsorbent, and the added amount accounts for 1-15% of the preparation mass; wherein the raw drug adsorbent is water-soluble chitosan.

[0013] When the sanitary insecticide preparation is in the form of a suspension, the dosage forms include, by weight percentage, 1-40% of tetrazobactam, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, 3-7% of an antifreeze agent, 0.3-2% of a preservative, 0.1-1% of a defoamer, 0.5-3% of a thickener, 1-15% of a technical adsorbent, and deionized water is added to 100%.

[0014] When the sanitary insecticide preparation is in the form of an oil suspension, it comprises the following raw materials in weight percentage: 1-40% of tetrazobactam, 1-10% of propoxur, 0.3-3% of a dispersant, 2-6% of an emulsifier, 0.2-5% of a defoamer, 0.2-5% of a thickener, 1-15% of a technical adsorbent, and the solvent is supplemented to 100%.

[0015] When the sanitary insecticide preparation is in the form of a dry suspension, it comprises the following raw materials in percentage by weight: 1-40% of tetrazopyram, 1-15% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, 1-10% of a technical adsorbent, and the filler is supplemented to 100%.

[0016] When the sanitary insecticide preparation is in the form of a wettable powder, it comprises the following raw materials in percentage by weight: 1-40% of tetrazopyram, 1-10% of propoxur, 2-6% of a wetting agent, 7-18% of a dispersant, 1-15% of a technical adsorbent, and the filler is supplemented to 100%.

[0017] When the sanitary insecticide preparation is in the form of water dispersible granules, it comprises the following raw materials in weight percentage: 1-40% of tetrazopyram, 1-10% of propoxur, 2-15% of wetting agent, 5-20% of dispersant, 2-8% of disintegrant, 1-15% of original drug adsorbent, and the filler is supplemented to 100%.

[0018] The original drug adsorbent is water-soluble chitosan.

[0019] The wetting agent is selected from any one of sodium naphthalenesulfonate, pull-opening powder BX, sodium alkyl sulfonate, dodecylbenzenesulfonic acid, sodium dodecyl sulfate, alkylbenzene polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether formaldehyde condensate sodium sulfate, phenethylphenol polyoxyethylene ether phosphate, and alkyl sodium sulfate, or a mixture of two or more in any proportion.

[0020] The dispersant is selected from any one of sodium polycarboxylate, sodium lignin sulfonate, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester, sodium naphthalenesulfonic acid formaldehyde condensate, alkylphenol polyoxyethylene ether formaldehyde condensate, nonionic hydroxy polyethylene oxide block copolymer, glycerol fatty acid ester polyoxyethylene ether, or a mixture of two or more in any proportion.

[0021] The emulsifier is selected from any one of castor oil polyoxyethylene ether, fatty alcohol polyoxyethylene ether, oleic acid polyoxyethylene ether, potassium sorbitan monooleate polyoxyethylene ether, and calcium dodecylbenzene sulfonate, or a mixture of two or more of the above in any proportion.

[0022] The antifreeze agent is selected from any one of ethylene glycol, propylene glycol, glycerol and urea, or a mixture of two or more of them in any proportion.

[0023] The preservative is selected from any one of sodium benzoate, paraformaldehyde, sodium dehydroacetate, potassium sorbate, or a mixture of two or more of the above in any proportion.

[0024] The defoaming agent is selected from any one of polydimethylsiloxane, silicone oil, glyceryl ricinoleate, distearyl ethylenediamine, or a mixture of two or more in any proportion.

[0025] The thickener is selected from any one of xanthan gum, magnesium aluminum silicate, hydroxyethyl cellulose, organic bentonite, and silicon dioxide, or a mixture of two or more of the above in any proportion.

[0026] The filler is selected from any one of kaolin, white carbon black, corn starch, attapulgite, calcium carbonate, light calcium, diatomaceous earth, and montmorillonite, or a mixture of two or more of the above in any proportion.

[0027] The disintegrant is selected from any one of sodium carboxymethyl starch, sodium chloride, ammonium sulfate, and sodium carbonate, or a mixture of two or more of the above in any proportion.

[0028] The dispersion medium is selected from any one of methyl oleate, rosin-based vegetable oil, paraffin oil, soybean oil, and epoxidized soybean oil, or a mixture of two or more of the above in any proportion.

[0029] When the dosage form of the sanitary insecticide preparation is a suspension, oil suspension, dry suspension, water dispersible granules and wettable powder, the weight percentages of tetrazobactam, propoxur and original drug adsorbent are first added into a food processor and mixed evenly, then air flow pulverized and mixed, and then prepared according to conventional methods or existing methods in the art.

[0030] When the sanitary insecticide composition or sanitary insecticide preparation is used to control sanitary pests, a residual spraying method is adopted: the sanitary insecticide composition or sanitary insecticide preparation is diluted 50-300 times with water and then sprayed on surfaces such as walls, doors, windows, ceilings and homes, so that the sanitary insecticide remains on the surfaces of the above objects, thereby knocking down and killing the sanitary pests.

[0031] Compared with the prior art, the composition of the present invention adopts two insecticides with different action mechanisms to improve the prevention effect and delay the generation of resistance, thus providing a new method for preventing and controlling sanitary pests. DETAILED DESCRIPTION

[0032] The specific implementation of the technical solution of the present invention is described in detail below, but the present invention is not limited to the following description:

[0033] The preparation method of the dosage form in each embodiment of the present invention is as follows:

[0034] The composition of the present invention combines tetrazobactam and propoxur. From the perspective of the mechanism of action, the combination of the two can avoid cross-resistance with traditional insecticides, thereby solving the resistance problem of sanitary pests such as mosquitoes, flies and cockroaches, improving the prevention effect and reducing the dosage; at the same time, tetrazobactam and propoxur have low irritation, which improves the safety of the pesticide applicators; furthermore, propoxur, as a lethal agent, itself has good knockdown performance, thereby also improving the prevention effect; at the same time, the two substances have good environmental compatibility, the combination has synergistic effect, is not easy to produce drug resistance and has a long lasting effect. The combination of the two insecticides with different action mechanisms at a specific ratio can also delay the generation of pest resistance.

[0035] The laboratory preparation method of the suspension is as follows: (1) adding the weight percentage of tetrazobactam, propoxur and original drug adsorbent to a food processor and mixing them evenly, and then mixing them by air flow crushing; (2) weighing a wetting agent, a dispersant, an antifreeze agent, a preservative, a defoaming agent and deionized water according to a ratio and adding them to a beaker and mixing them evenly, adding the active ingredient powder obtained in step (1) to the beaker and mixing them evenly, and then transferring it to a sand mill, adding zirconium oxide beads to the sand mill, grinding for 2-3 hours, adding a thickener and continuing to grind for 0.5 hours, and making the particle size D 95 The product can be obtained by controlling the particle size below 5 microns and filtering to remove the zirconium oxide beads.

[0036] The laboratory preparation method of the oil suspension is as follows: (1) adding the weight percentage of tetrazobactam, propoxur and original drug adsorbent to a food processor and mixing them evenly, and then mixing them by air flow crushing; (2) weighing a dispersant, an emulsifier, a defoamer and a dispersion medium according to a ratio and adding them to a beaker and mixing them evenly, adding the active ingredient powder obtained in step (1) to the beaker and mixing them evenly, and then transferring it to a sand mill, adding zirconium oxide beads to the sand mill, grinding for 2-3 hours, adding a thickener and continuing to grind for 0.5 hours, and making the particle size D 95 The product can be obtained by controlling the particle size below 5 microns and filtering to remove the zirconium oxide beads.

[0037] The laboratory preparation method of the dry suspension is as follows: (1) adding the weight percentage of tetrazobactam, propoxur and original drug adsorbent to a food processor and mixing them evenly, and then mixing them by air flow crushing; (2) weighing a wetting agent, a dispersant, a filler and water according to a proportion and adding them to a beaker and mixing them evenly, adding the active ingredient powder obtained in step (1) to the beaker and mixing them evenly, and then transferring it to a sand mill, adding zirconium oxide beads to the sand mill, and grinding for 2-3 hours to make the particle size D 95 The particle size is controlled below 5 microns, the zirconium oxide beads are removed by filtration, and the obtained material is dried by a spray dryer to obtain the product.

[0038] The laboratory preparation method of the wettable powder is as follows: (1) adding the weight percentages of tetrazobactam, propoxur and the original drug adsorbent into a food processor, mixing them evenly, and then mixing them by air flow pulverization; (2) weighing the wetting agent, dispersant, filler and the active ingredient powder obtained in step (1) according to the proportion, adding them into a food processor, mixing them evenly, and then pulverizing them in an air flow pulverizer to obtain the wettable powder.

[0039] The laboratory preparation method of water dispersible granules is as follows: (1) adding the weight percentages of tetrazobactam, propoxur and original drug adsorbent into a food processor, mixing them evenly, and then mixing them by air flow pulverization; (2) weighing a wetting agent, a dispersant, a disintegrant, a filler and the active ingredient powder obtained in step (1) according to a proportion, adding them into a food processor, mixing them evenly, and then pulverizing them in an air flow pulverizer, mixing them again with the food processor, adding an appropriate amount of water, extruding and granulating them with a granulator, and drying them in an oven at 45°C.

[0040] The present invention will be described below in conjunction with specific embodiments:

[0041] Formulation Example 1: 16% tetrazolyl phthalide·propoxur wettable powder: 15% tetrazolyl phthalide, 1% propoxur, 2% sodium naphthalenesulfonate, 18% sodium polycarboxylate, 5% water-soluble chitosan, kaolin is added to make up to 100%.

[0042] Formulation Example 2: 20% tetrazolyl cypermethrin·propoxur wettable powder: 18% tetrazolyl cypermethrin, 2% propoxur, 3% lakai powder BX, 15% sodium lignin sulfonate, 7% water-soluble chitosan, 10% white carbon black, and kaolin is added to make up to 100%.

[0043] Formulation Example 3: 20% tetrazolyl thiamethoxam·propoxur wettable powder: 15% tetrazolyl thiamethoxam, 5% propoxur, 4% sodium alkyl sulfonate, 12% fatty amine polyoxyethylene ether, 6% water-soluble chitosan, and diatomaceous earth is added to make up to 100%.

[0044] Formulation Example 4: 10% tetrazobactam·propoxur wettable powder: 1% tetrazobactam, 9% propoxur, 5% dodecylbenzenesulfonic acid, 9% polyoxyethylene fatty acid ester, 14% water-soluble chitosan, and attapulgite is added to make up to 100%.

[0045] Formulation Example 5: 26% tetrazolin·propoxur wettable powder: 24% tetrazolin, 2% propoxur, 6% sodium lauryl sulfate, 7% sodium naphthalenesulfonic acid formaldehyde condensate, 9% water-soluble chitosan, and calcium carbonate is supplemented to 100%.

[0046] Formulation Example 6: 21% tetrazolin·propoxur wettable powder: 18% tetrazolin, 3% propoxur, 2% alkylbenzene polyoxyethylene ether phosphate, 10% alkylphenol polyoxyethylene ether formaldehyde condensate, 7% water-soluble chitosan, light calcium supplemented to 100%.

[0047] Formulation Example 7: 12% tetrazobactam·propoxur wettable powder: 3% tetrazobactam, 9% propoxur, 2% sodium sulfate of alkylphenol polyoxyethylene ether formaldehyde condensate, 10% non-ionic hydroxy polyethylene oxide block copolymer, 4% water-soluble chitosan, and montmorillonite is supplemented to 100%.

[0048] Formulation Example 8: 16% Tetrazodone Carbendazim·Propoxur Suspension Concentrate

[0049] 15% of tetrazobactam, 1% of propoxur, 1% of sodium alkyl sulfate, 8% of sodium polycarboxylate, 5% of ethylene glycol, 1% of sodium benzoate, 1% of polydimethylsiloxane, 0.5% of xanthan gum, 5% of water-soluble chitosan, and deionized water is added to 100%.

[0050] Formulation Example 9: 20% Tetrazodone Carbendazim·Propoxur Suspension Concentrate

[0051] 18% of tetrazobactam, 2% of propoxur, 5% of phenethylphenol polyoxyethylene ether phosphate, 5% of glycerol fatty acid ester polyoxyethylene ether, 7% of propylene glycol, 2% of polyformaldehyde, 1% of silicone oil, 1% of magnesium aluminum silicate, 7% of water-soluble chitosan, and deionized water is added to 100%.

[0052] Formulation Example 10: 20% Tetrazodone Carbendazim·Propoxur Suspension Concentrate

[0053] 15% of tetrazobactam, 5% of propoxur, 6% of sodium sulfate of alkylphenol polyoxyethylene ether formaldehyde condensate, 4% of glycerol fatty acid ester polyoxyethylene ether, 4% of glycerol, 1.5% of sodium dehydroacetate, 1% of glycerol ricinoleate, 2% of hydroxyethyl cellulose, 6% of water-soluble chitosan, and deionized water is added to 100%.

[0054] Formulation Example 11: 10% Tetrazodone Carbendazim·Propoxur Suspension Concentrate

[0055] 1% of tetrazobactam, 9% of propoxur, 8% of alkylbenzene polyoxyethylene ether phosphate, 1% of sodium naphthalenesulfonic acid formaldehyde condensate, 3% of urea, 0.3% of potassium sorbate, 0.5% of distearyl ethylenediamine, 3% of organic bentonite, 4% of water-soluble chitosan, and deionized water is added to 100%.

[0056] Formulation Example 12: 10% tetrazolin·propoxur oil suspension: 9% tetrazolin, 1% propoxur, 2% non-ionic hydroxypolyethylene oxide block copolymer, 6% castor oil polyoxyethylene ether, 5% silicone oil, 0.2% silicon dioxide, 3% water-soluble chitosan, and methyl oleate is supplemented to 100%.

[0057] Formulation Example 13: 11% tetrazolylcarb·propoxur oil suspension: 10% tetrazolylcarb, 1% propoxur, 3% fatty amine polyoxyethylene ether, 6% fatty alcohol polyoxyethylene ether, 3% distearyl ethylenediamine, 0.5% silicon dioxide, 4% water-soluble chitosan, and rosin-based vegetable oil is supplemented to 100%.

[0058] Formulation Example 14: 4% tetrazobactam·propoxur oil suspension: 3% tetrazobactam, 1% propoxur, 0.7% sodium polycarboxylate, 4% oleic acid polyoxyethylene ether, 2% glycerol ricinoleate, 1% xanthan gum, 1% water-soluble chitosan, and paraffin oil is supplemented to 100%.

[0059] Formulation Example 15: 3% tetrazolin·propoxur oil suspension: 2% tetrazolin, 1% propoxur, 0.5% alkylphenol polyoxyethylene ether formaldehyde condensate, 2% potassium sorbitan monooleate polyoxyethylene ether, 0.5% polydimethylsiloxane, 4% xanthan gum, 1% water-soluble chitosan, and soybean oil is supplemented to 100%.

[0060] Formulation Example 16: 2% tetrazolyl amide·propoxur oil suspension: 1% tetrazolyl amide, 1% propoxur, 0.3% sodium polycarboxylate, 2% calcium dodecylbenzenesulfonate, 0.2% distearyl ethylenediamine, 5% magnesium aluminum silicate, 1% water-soluble chitosan, and epoxidized soybean oil is supplemented to 100%.

[0061] Formulation Example 17: 10% tetrazolin·propoxur dry suspension: 1% tetrazolin, 9% propoxur, 5% alkylbenzene polyoxyethylene ether phosphate, 5% glycerol fatty acid ester polyoxyethylene ether, 3% water-soluble chitosan, kaolin is added to make up to 100%.

[0062] Formulation Example 18: 9% tetrazobactam·propoxur dry suspension: 1% tetrazobactam, 8% propoxur, 8% sodium sulfate of alkylphenol polyoxyethylene ether formaldehyde condensate, 8% sodium lignin sulfonate, 4% water-soluble chitosan, and kaolin is added to make up to 100%.

[0063] Formulation Example 19: 3% tetrazobactam·propoxur dry suspension: 1% tetrazobactam, 2% propoxur, 1% sodium naphthalenesulfonate, 1% sodium polycarboxylate, 1% water-soluble chitosan, and kaolin is added to make up to 100%.

[0064] Formulation Example 20: 4% tetrazobactam·propoxur dry suspension: 1% tetrazobactam, 3% propoxur, 3% sodium alkyl sulfate, 3% fatty amine polyoxyethylene ether, 1% water-soluble chitosan, and kaolin is added to make up to 100%.

[0065] Formulation Example 21: 39% tetrazolin·propoxur water dispersible granules: 36% tetrazolin, 3% propoxur, 2% phenethylphenol polyoxyethylene ether phosphate, 20% fatty acid polyoxyethylene ester, 2% ammonium sulfate, 13% water-soluble chitosan, and corn starch is supplemented to 100%.

[0066] Formulation Example 22: 44% tetrazolin·propoxur water dispersible granules: 40% tetrazolin, 4% propoxur, 12% lakai powder BX, 10% sodium naphthalenesulfonic acid formaldehyde condensate, 2% sodium chloride, 3% sodium carbonate, 14% water-soluble chitosan, and corn starch is supplemented to 100%.

[0067] Formulation Example 23: 50% tetrazolin·propoxur water dispersible granules: 40% tetrazolin, 10% propoxur, 15% sodium alkyl sulfonate, 5% alkylphenol polyoxyethylene ether formaldehyde condensate, 8% sodium carboxymethyl starch, 15% water-soluble chitosan, and corn starch is supplemented to 100%.

[0068] Formulation Example 24: 21% tetrazolin·propoxur wettable powder: 18% tetrazolin, 3% propoxur, 2% alkylbenzene polyoxyethylene ether phosphate, 10% alkylphenol polyoxyethylene ether formaldehyde condensate, light calcium supplemented to 100%.

[0069] Formulation Example 25: 12% tetrazolyl cypermethrin·propoxur wettable powder 3% tetrazolyl cypermethrin, 9% propoxur, 2% sodium sulfate of alkylphenol polyoxyethylene ether formaldehyde condensate, 10% nonionic hydroxy polyethylene oxide block copolymer, montmorillonite is added to 100%. Formulation Example 26: 4% tetrazolyl cypermethrin·propoxur dry suspension 1% tetrazolyl cypermethrin, 3% propoxur, 3% sodium alkyl sulfate, 3% fatty amine polyoxyethylene ether, kaolin is added to 100%.

[0070] Application Example 1: Co-toxicity coefficient of tetrazobactam and propoxur against Culex pipiens pallens Test subject: Culex pipiens pallens (laboratory breeding); Test method: Refer to the first part of the pesticide indoor bioassay test guidelines for pesticides: contact activity test, and use the drip method NY / T1154.1-2006 to carry out activity determination test on Culex pipiens pallens; Data statistics: The co-toxicity coefficient method is used to evaluate the activity of the combination of the two against Culex pipiens pallens. Then the LC of each drug is calculated using DPS statistical software 50 The value is then used to calculate the toxicity index and co-toxicity coefficient of the agent according to the Sun Yunpei method. A co-toxicity coefficient greater than 120 indicates a synergistic effect, a co-toxicity coefficient between 80-120 indicates an additive effect, and a co-toxicity coefficient less than 80 indicates an antagonistic effect. The test results are shown in the following table:

[0071] Table 1 Co-toxicity coefficient of tetrazobactam and propoxur to Culex pipiens pallens

[0072]

[0073] It can be seen from Table 1 that the co-toxicity coefficient of tetrazobactam:propoxur at the ratio of 9:1 to 3:1 is greater than 120, which is a synergistic effect.

[0074] Application Example 2: Experiment on the efficacy of drugs for preventing and controlling mosquitoes and flies

[0075] Test subjects: Culex pipiens and housefly (laboratory reared);

[0076] Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, residual spray test;

[0077] Control sample 1: 16% tetrazopyrim WP

[0078] 16% of tetrazobactam, 2% of sodium naphthalenesulfonate, 18% of sodium polycarboxylate, 5% of water-soluble chitosan, and kaolin is added to 100%.

[0079] Control 2: 16% propoxur WP

[0080] 16% of propoxur, 2% of sodium naphthalenesulfonate, 18% of sodium polycarboxylate, 5% of water-soluble chitosan, and kaolin is added to make up to 100%.

[0081] Control sample 3: 20% tetrazobactam suspension

[0082] 20% tetrazobactam, 5% phenethylphenol polyoxyethylene ether phosphate, 5% glycerol fatty acid ester polyoxyethylene ether, 7% propylene glycol, 2% polyformaldehyde, 1% silicone oil, 1% magnesium aluminum silicate, 7% water-soluble chitosan, and deionized water is added to 100%.

[0083] Control 4: 20% Propoxur SC

[0084] 20% propoxur, 5% phenethylphenol polyoxyethylene ether phosphate, 5% glycerol fatty acid ester polyoxyethylene ether, 7% propylene glycol, 2% polyformaldehyde, 1% silicone oil, 1% magnesium aluminum silicate, 7% water-soluble chitosan, and deionized water is added to 100%.

[0085] Control sample 5: 10% chlorpromazine·propoxur suspension (commercially available)

[0086] Control sample 6: 15% cischlorfenapyr suspension (commercially available)

[0087] Test treatment: The total concentration of active ingredients in the preparation examples and the control agent was diluted to 1000 ppm; Test results:

[0088] Table 2 Residual spraying efficacy test of some formulation examples against Culex pipiens pallens and housefly

[0089]

[0090] As can be seen from Table 2, the combination of tetrazobactam and propoxur has a significant synergistic effect on the knockdown and lethality of mosquitoes and flies, and compared with commercially available products, the knockdown and lethality of the present invention against mosquitoes and flies are higher.

[0091] Application Example 3: Efficacy test of the original drug adsorbent Test target: Culex pipiens pallens, female adults that have not sucked blood on the 3rd to 5th day after emergence;

[0092] Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, residual spray test;

[0093] Control sample 5: 10% chlorpromazine·propoxur suspension (commercially available)

[0094] Control sample 6: 15% cischlorfenapyr suspension (commercially available)

[0095] Test treatment: Preparation examples, diluted to 1000 ppm according to the total concentration of active ingredients;

[0096] Test results:

[0097] Table 3 Sustained-release and sustained-effect test of some formulation examples against mosquitoes and flies

[0098]

[0099] As shown in Table 3, after 15 days of exposure to air, the formulation examples still have a good knockdown effect on mosquitoes and flies, the efficacy decreases slowly, and the duration of efficacy is long, while the efficacy of control samples 5 and 6 (commercially available) decreases rapidly after 15 days, the knockdown rate is significantly slowed down, and the mortality rate is significantly reduced. In addition, after adding the original drug adsorbent to the formula, the efficacy of the 15-day drug decreases more slowly.

[0100] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. A sanitary insecticidal composition, characterized in that: The composition comprises tetrazobactam and propoxur, wherein the weight ratio of tetrazobactam to propoxur is 15:1 to 1:

9.

2. An application of the sanitary insecticide composition according to claim 1, characterized in that: The sanitary insecticide composition is used to prevent and control sanitary pests in places where sanitary pests appear.

3. A sanitary insecticide preparation, active ingredients and adjuvants, characterized in that: The active ingredient in the preparation is the composition according to claim 1, and the composition accounts for 2% to 50% of the total weight of the insecticide group.

4. The sanitary insecticide preparation according to claim 3, characterized in that: The preparation dosage forms are suspension concentrate, oil suspension concentrate, dry suspension concentrate, wettable powder and water dispersible granules.

5. The sanitary insecticide preparation according to claim 3 or 4, characterized in that: The auxiliary agent in the preparation is any one or more of a dispersant, a wetting agent, a disintegrant, a filler, an antifreeze agent, a thickener, a preservative, a defoamer, a solvent, an emulsifier, an encapsulating material, an organic amine and deionized water.

6. The sanitary insecticide preparation according to claim 3, characterized in that: The auxiliary agent also contains a raw drug adsorbent, and the added amount accounts for 1-15% of the preparation mass; wherein the raw drug adsorbent is water-soluble chitosan.

7. The sanitary insecticide preparation according to claim 6, characterized in that: When the sanitary insecticide preparation is in the form of a suspension, the dosage form includes, by weight percentage, 1-40% of tetrazobactam, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, 3-7% of an antifreeze agent, 0.3-2% of a preservative, 0.1-1% of a defoamer, 0.5-3% of a thickener, 1-15% of a technical adsorbent, and deionized water is added to 100%; When the sanitary insecticide preparation is in the form of an oil suspension, it comprises the following raw materials in weight percentage: 1-40% of tetrazobactam, 1-10% of propoxur, 0.3-3% of a dispersant, 2-6% of an emulsifier, 0.2-5% of a defoamer, 0.2-5% of a thickener, 1-15% of a technical adsorbent, and the solvent is supplemented to 100%.

8. The sanitary insecticide preparation according to claim 6, characterized in that: When the dosage form of the sanitary insecticide preparation is a dry suspension, it comprises the following raw materials in weight percentage: 1-40% of tetrazobactam, 1-15% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, 1-10% of a technical adsorbent, and the filler is supplemented to 100%; When the sanitary insecticide preparation is in the form of a wettable powder, it comprises the following raw materials in percentage by weight: 1-40% of tetrazopyram, 1-10% of propoxur, 2-6% of a wetting agent, 7-18% of a dispersant, 1-15% of a technical adsorbent, and the filler is supplemented to 100%.

9. The sanitary insecticide preparation according to claim 6, characterized in that: When the sanitary insecticide preparation is in the form of water dispersible granules, it comprises the following raw materials in weight percentage: 1-40% of tetrazopyram, 1-10% of propoxur, 2-15% of wetting agent, 5-20% of dispersant, 2-8% of disintegrant, 1-15% of original drug adsorbent, and the filler is supplemented to 100%.

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