Disinfectant and preparation method thereof

Abstract

The invention discloses a disinfectant and a preparation method thereof, and belongs to the field of disinfection products. The disinfectant is prepared from the following components in percentage by mass: 1 to 3 percent of hydrogen peroxide, 10 to 30 percent of alcohol, 0.1 to 2 percent of stabilizer, 0.1 to 0.5 percent of synergist, 0.1 to 1 percent of surfactant and the balance of water, according to the disinfectant, by adding the stabilizer, the decomposition speed of hydrogen peroxide is remarkably reduced, so that the storage stability of hydrogen peroxide is improved; a silver bromide synergist which is chelated by chitosan is added, and the silver bromide synergist and hydrogen peroxide form a synergistic effect, so that the sterilization efficiency of the disinfectant is remarkably improved; meanwhile, through chelation treatment on the silver bromide, the hydrogen peroxide can be stored in a dark place and has very good stability, so that the storage stability of the hydrogen peroxide cannot be influenced; the disinfectant has better storage stability and sterilization energy efficiency under the condition that the content of hydrogen peroxide is not increased, and is more suitable for large-scale popularization and application.

Description

Technical Field

[0001] The invention relates to the technical field of disinfectant products, and in particular to a disinfectant and a preparation method thereof. Background Art

[0002] In our daily life, disinfection products, as a common product, play a very important role. People pay more and more attention to the disinfection of viruses and bacteria in the environment. Therefore, disinfection products are also getting more and more attention. There are various disinfection products on the market, among which hydrogen peroxide aqueous solution is very popular because it has no residue after use and good disinfection and sterilization effect. It is one of the most widely used disinfection products.

[0003] Hydrogen peroxide aqueous solution is a liquid with two hydrogen atoms and two oxygen atoms in each molecule. It has strong permeability and oxidation, and can form free hydroxyl groups and active derivatives with strong oxidation ability in water. During its decomposition process, it releases extremely active new ecological oxygen [O], which can destroy the cell membrane and protoplasm of microorganisms to achieve the purpose of inactivation. Hydrogen peroxide has strong oxidation ability and a wide bactericidal spectrum. It can kill intestinal pathogens, pyogenic cocci, pathogenic yeasts, common bacteria in hospital infections, human tuberculosis mycobacterium and common bacteria in the air. It is also suitable for environmental surface disinfection and general object surface disinfection in medical institutions, public places, and homes, as well as air disinfection.

[0004] Hydrogen peroxide is an environmentally friendly disinfectant that eventually decomposes into oxygen and water, causing no pollution to the environment. However, hydrogen peroxide also has the disadvantages of being highly corrosive at high concentrations and having poor stability and bactericidal efficacy at low concentrations, which seriously limits the scope of application of hydrogen peroxide disinfectants. Summary of the invention

[0005] The purpose of the present invention is to overcome the defects of poor stability and poor bactericidal efficacy of the existing hydrogen peroxide disinfectant, and to provide a disinfectant and a preparation method thereof.

[0006] A disinfectant comprises the following components in percentage by mass: 1-3% hydrogen peroxide, 10-30% alcohol, 0.1-2% stabilizer, 0.1-0.5% synergist, 0.1-1% surfactant, and the balance is water; wherein the synergist is a chelate of chitosan and silver bromide.

[0007] The disinfectant of the present invention not only significantly reduces the decomposition speed of hydrogen peroxide by adding a stabilizer, thereby improving the storage stability of hydrogen peroxide; but also adds a silver bromide synergist that has been chelated with chitosan, so that when the disinfectant is used, the silver bromide synergist can be quickly decomposed under light conditions to release silver ions and chitosan monomers, and form a synergistic effect with hydrogen peroxide, thereby significantly improving the bactericidal efficiency of the disinfectant; at the same time, through the chelation treatment of silver bromide, the disinfectant can have good stability when stored in a dark place, thereby not affecting the storage stability of hydrogen peroxide; the disinfectant can significantly improve the storage stability and bactericidal energy efficiency of the disinfectant without increasing the content of hydrogen peroxide, and is more suitable for large-scale promotion and application.

[0008] Preferably, the alcohol is at least one of methanol, ethanol, isopropanol or butanol.

[0009] Among them, preferably, the stabilizer is at least one of organic phosphonic acid or maleic acid-acrylic acid copolymer.

[0010] Preferably, the organic phosphonic acid is one of pyridine dicarboxylic acid, hydroxyethylidene diphosphonic acid, dihexylene triamine penta methylene phosphonic acid, 8-hydroxyquinoline, ethylenediamine tetra methylene phosphonic acid, hexamethylene diamine tetra methylene phosphonic acid, diethylene triamine penta methylene phosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, amino trimethylene phosphonic acid pyrophosphate, hydroxytoluene diphosphate, inositol hexaphosphate, and polyphosphoric acid.

[0011] More preferably, the stabilizer is maleic acid-acrylic acid copolymer (MA / AA); the carboxyl group (-COOH) in MA / AA can form a stable complex with the oxygen atom in hydrogen peroxide, thereby significantly reducing the decomposition rate of hydrogen peroxide; at the same time, MA / AA can also complex with metal ions, thereby reducing the content of metal ions in the disinfectant, avoiding metal ions catalyzing the decomposition of hydrogen peroxide, and better improving the stability of the aqueous hydrogen peroxide solution.

[0012] Further preferably, the molecular weight of the maleic acid-acrylic acid copolymer is not greater than 400; if the molecular weight is too large, the solubility and complexing ability are reduced, which is not conducive to improving the stability of the disinfectant.

[0013] Among them, preferably, in the enhancer, the molar ratio of chitosan to silver ions is 2-4:1; if the chitosan content is too low, the silver ions cannot be effectively shielded, and free silver ions will be generated during storage. If the chitosan content is too high, the silver ions will be excessively shielded and it will be difficult to dissolve. When used, it is not easy to release silver ions, which is beneficial to improve the bactericidal effect of the disinfectant.

[0014] Preferably, the preparation method of the synergist comprises: adding chitosan to a silver bromide solution, stirring and dissolving, and then reacting at 80-90° C. for 0.5-2 h to obtain a chelate of chitosan and silver bromide.

[0015] Preferably, the concentration of the silver bromide solution is 0.1-0.5 mol / L.

[0016] Among them, preferably, the surfactant is at least one of a cationic surfactant and an anionic surfactant.

[0017] More preferably, the surfactant is at least one of benzalkonium chloride, benzalkonium bromide, didecyldimethylammonium chloride, disoctyldimethylammonium chloride, octyl sulfonate, octyl sulfate, and octyl succinate.

[0018] Furthermore, the present invention also provides a method for preparing a disinfectant, comprising the following steps:

[0019] (1) adding alcohol and a stabilizer to an aqueous hydrogen peroxide solution, stirring and mixing to obtain a mixed solution A;

[0020] (2) adding a synergist and a surfactant to the mixed solution A and stirring the mixture to obtain a mixed solution B;

[0021] (3) Add water to the mixed solution B to adjust the concentration to obtain a disinfectant solution.

[0022] In the production process of the disinfectant, low-speed stirring is continuously performed, which is beneficial to the dissolution and mixing of the components, reduces energy consumption, and is conducive to large-scale production; preferably, the stirring speed is 50-100r / min.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] (1) The disinfectant of the present invention significantly reduces the decomposition rate of hydrogen peroxide by adding a stabilizer, thereby improving the storage stability of hydrogen peroxide.

[0025] (2) The disinfectant of the present invention adds a silver bromide enhancer that has been chelated with chitosan, so that when the disinfectant is used, the silver bromide enhancer can be quickly decomposed under light conditions to release silver ions and chitosan monomers, and form a synergistic effect with hydrogen peroxide, thereby significantly improving the bactericidal efficacy of the disinfectant.

[0026] (3) The disinfectant of the present invention has good stability when stored in a dark place by chelating silver bromide, thereby improving the bactericidal efficacy without affecting the storage stability of hydrogen peroxide.

[0027] (4) The disinfectant of the present invention can significantly improve the storage stability and sterilization efficiency of the disinfectant without increasing the hydrogen peroxide content.

[0028] (5) The preparation method of the disinfectant of the present invention is simple, reliable, has a wide range of applications, is low in cost, and is suitable for large-scale promotion and application. DETAILED DESCRIPTION

[0029] The present invention is further described in detail below in conjunction with test examples and specific implementation methods. However, this should not be understood as the scope of the above subject matter of the present invention being limited to the following embodiments, and all technologies realized based on the content of the present invention belong to the scope of the present invention.

[0030] Example 1

[0031] A disinfectant comprising the following components in percentage by mass: 2% hydrogen peroxide, 20% alcohol (isopropyl alcohol), 1% stabilizer (maleic acid-acrylic acid copolymer), 0.25% synergist, 0.5% surfactant (sodium octyl sulfate), and the balance water;

[0032] The preparation method of the synergist includes: adding chitosan to a silver bromide solution (0.2 mol / L) and stirring to dissolve, and then reacting at 80°C for 1 hour to obtain a chelate of chitosan and silver bromide (the molar ratio of chitosan to silver ion is 3:1).

[0033] Example 2

[0034] A disinfectant comprises the following components in percentage by mass: 3% hydrogen peroxide, 10% alcohol (isopropyl alcohol), 2% stabilizer (hydroxyethylidene diphosphonic acid), 0.1% synergist, 1% surfactant (benzalkonium chloride), and the balance is water;

[0035] The preparation method of the synergist includes: adding chitosan to a silver bromide solution (0.2 mol / L) and stirring to dissolve, and then reacting at 85°C for 1 hour to obtain a chelate of chitosan and silver bromide (the molar ratio of chitosan to silver ion is 2:1).

[0036] Example 3

[0037] A disinfectant, comprising the following components in percentage by mass: 1% hydrogen peroxide, 30% alcohol (ethanol), 0.1% stabilizer (maleic acid-acrylic acid copolymer), 0.5% synergist, 0.1% surfactant (bisoctyl dimethyl ammonium chloride), and the balance is water;

[0038] The preparation method of the synergist includes: adding chitosan to a silver bromide solution (0.5 mol / L) and stirring to dissolve, and then reacting at 90°C for 0.5 h to obtain a chelate of chitosan and silver bromide (the molar ratio of chitosan to silver ion is 4:1).

[0039] Example 4

[0040] A disinfectant comprising the following components in percentage by mass: 2% hydrogen peroxide, 20% alcohol (isopropyl alcohol), 1% stabilizer (diethylenetriamine penta (methylenephosphonic acid), 0.25% synergist, 0.5% surfactant (sodium octyl sulfate), and the balance water;

[0041] The preparation method of the synergist includes: adding chitosan to a silver bromide solution (0.2 mol / L) and stirring to dissolve, and then reacting at 80°C for 2 hours to obtain a chelate of chitosan and silver bromide (the molar ratio of chitosan to silver ion is 3:1).

[0042] Example 5

[0043] A disinfectant comprising the following components in percentage by mass: 2% hydrogen peroxide, 20% alcohol (isopropyl alcohol), 1% stabilizer (maleic acid-acrylic acid copolymer), 0.3% synergist, 0.3% surfactant (sodium octyl succinate), and the balance water;

[0044] The preparation method of the synergist includes: adding chitosan to a silver bromide solution (0.1 mol / L) and stirring to dissolve, and then reacting at 80°C for 2 hours to obtain a chelate of chitosan and silver bromide (the molar ratio of chitosan to silver ion is 1:1).

[0045] Example 6

[0046] A disinfectant comprising the following components in percentage by mass: 2% hydrogen peroxide, 20% alcohol (isopropyl alcohol), 1% stabilizer (maleic acid-acrylic acid copolymer), 0.3% synergist, 0.3% surfactant (sodium octyl succinate), and the balance water;

[0047] The preparation method of the synergist includes: adding chitosan to a silver bromide solution (0.1 mol / L) and stirring to dissolve, and then reacting at 80°C for 2 hours to obtain a chelate of chitosan and silver bromide (the molar ratio of chitosan to silver ion is 5:1).

[0048] Comparative Example 1

[0049] A disinfectant comprising the following components in percentage by mass: 2% hydrogen peroxide, 20% alcohol (isopropyl alcohol), 1% stabilizer (maleic acid-acrylic acid copolymer), 0.6% synergist, 0.3% surfactant (sodium octyl succinate), and the balance water;

[0050] Among them, the preparation method of the enhancer includes: adding chitosan to a silver bromide solution (0.1 mol / L) and stirring to dissolve, and then reacting at 80°C for 2 hours to obtain a chelate of chitosan and silver bromide (the molar ratio of chitosan to silver ion is 3:1).

[0051] Comparative Example 2:

[0052] A disinfectant comprising the following components in percentage by mass: 2% hydrogen peroxide, 20% alcohol (isopropyl alcohol), 2.5% stabilizer (maleic acid-acrylic acid copolymer), 0.25% synergist, 0.5% surfactant (sodium octyl sulfate), and the balance water;

[0053] The preparation method of the synergist includes: adding chitosan to a silver bromide solution (0.2 mol / L) and stirring to dissolve, and then reacting at 80°C for 1 hour to obtain a chelate of chitosan and silver bromide (the molar ratio of chitosan to silver ion is 3:1).

[0054] Comparative Example 3

[0055] A disinfectant comprising the following components in percentage by mass: 4% hydrogen peroxide, 20% alcohol (isopropyl alcohol), 1% stabilizer (maleic acid-acrylic acid copolymer), 0.25% synergist, 0.5% surfactant (sodium octyl sulfate), and the balance water;

[0056] The preparation method of the synergist includes: adding chitosan to a silver bromide solution (0.2 mol / L) and stirring to dissolve, and then reacting at 80°C for 1 hour to obtain a chelate of chitosan and silver bromide (the molar ratio of chitosan to silver ion is 3:1).

[0057] Comparative Examples 4-7

[0058] In Comparative Examples 4-7, compared with Example 1, the difference is that the ingredients of the components in the disinfectant are different, and the specific ingredients are as follows:

[0059] Group No. Disinfectant Comparative Example 4 The synergist is a mixture of chitosan and silver bromide in a molar ratio of 3:1 Comparative Example 5 Chitosan Comparative Example 6 Silver bromide Comparative Example 7 The synergist is a chelate of chitosan and silver nitrate in a molar ratio of 3:1.

[0060] Comparative Example 8

[0061] The disinfectant in Example 1 of patent CN115474610B: hydrogen peroxide aqueous solution: 10%, deacylated chitosan: 6.5%, hydroquinone: 0.065%, sodium stannate; 0.01%, BP-4: 0.0%, and the balance is acidic aqueous solution, forming a hydrogen peroxide disinfectant with a hydrogen peroxide weight content of 0.3% and a pH value of 3.5.

[0062] Comparative Example 9

[0063] The disinfectant in Example 1 of Patent CN114747575B: Agent A: 1918.8 mL of hydrogen peroxide, 246 mL of hydroxyethylidene diphosphonic acid, 123 g of aminotriacetic acid, 75.2 g of ethylenediaminetetramethylenephosphonic acid pentasodium, 97.0 g of benzotriazole, 1230 mL of potassium salt of polyether phosphate H-66, 710 mL of propylene glycol and 520 mL of polypropylene glycol-200; Agent B: 25.58 mL of N-acetylcaprolactam, 6.40 mL of N-acetyloctanolactam, 2.0 mL of 2-amino-2-methyl-1-propanol, 2.1 mL of N,N,N-triethylamine, 25.72 mL of propylene glycol, 5.1 mL of isopropanol and polyether 50-HB-660 15.1mL, prepare Agent A and Agent B according to the above proportions respectively, add Agent B into Agent A, the volume ratio of Agent B to Agent A is 1:60, mix for 5 minutes at room temperature, and you can get a peracetic acid disinfectant with a mass concentration of 0.3%.

[0064] Experimental example:

[0065] 1. Sterilization effect detection

[0066] Experimental bacteria: Escherichia coli 8099, Staphylococcus aureus ATCC6538.

[0067] Bacterial culture: The above-mentioned strains were inoculated into beef extract peptone medium and cultured at 37°C for 24 hours.

[0068] Experimental method: The disinfectants in Examples 1-6 and Comparative Examples 1-9 of the present invention were used as the experimental group, and ordinary physiological saline was used as the blank group. Five parallel experiments were conducted in each group, and 20 ml was taken from each group and placed in a sterile culture dish; a small amount of bacteria cultured in the culture dish was picked up with an inoculation loop and placed in a test tube containing sterile physiological saline, and shaken to form a bacterial suspension; 0.2 ml of the prepared bacterial suspension was placed in the culture dishes containing the disinfectants in the experimental group and the blank group, respectively, mixed evenly, and placed outdoors, and the bactericidal effect was observed at 1 min, 5 min, and 10 min. The experiment adopted colony count, and the experimental data of 5 groups were averaged, and the calculation results are shown in Table 1.

[0069] 2. Decrease rate of hydrogen peroxide

[0070] 10 ml of hydrogen peroxide disinfectant in Examples 1-6 and Comparative Examples 1-9 were taken, and 2 ml of an aqueous solution containing 1 mg / L of iron ions was added respectively, and placed in a black plastic bottle. The bottle mouth was tightly covered with a flip-top rubber stopper. After being placed outdoors at normal temperature and pressure for 5 months, the hydrogen peroxide content of the hydrogen peroxide disinfectant before and after placement was determined using the potassium permanganate method, and the decrease rate of hydrogen peroxide in the disinfectant was calculated by ((hydrogen peroxide content before storage-hydrogen peroxide content after storage) / hydrogen peroxide content before storage). Each group was tested 5 times in parallel, and the average value was removed. The measurement results are shown in Table 1.

[0071]

[0072]

[0073] From the experimental results in Table 1, it can be seen that by adding stabilizers and synergists of specific components to the disinfectant of the present invention, the stability and bactericidal effect of the disinfectant can be significantly improved, and the disinfectant is suitable for large-scale promotion and application.

Claims

1. A disinfectant, characterized in that: The invention comprises the following components in mass percentage: 1-3% hydrogen peroxide, 10-30% alcohol, 0.1-2% stabilizer, 0.1-0.5% synergist, 0.1-1% surfactant, and the balance is water; wherein the synergist is a chelate of chitosan and silver bromide.

2. The disinfectant according to claim 1, characterized in that: The alcohol is at least one of methanol, ethanol, isopropanol or butanol.

3. The disinfectant according to claim 1, characterized in that: The stabilizer is at least one of an organic phosphonic acid or a maleic acid-acrylic acid copolymer.

4. The disinfectant according to claim 3, characterized in that: The organic phosphonic acid is one of pyridine dicarboxylic acid, hydroxyethylidene diphosphonic acid, dihexylene triamine penta methylene phosphonic acid, 8-hydroxyquinoline, ethylenediamine tetra methylene phosphonic acid, hexamethylene diamine tetra methylene phosphonic acid, diethylene triamine penta methylene phosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, amino trimethylene phosphonic acid pyrophosphate, hydroxytoluene diphosphate, inositol hexaphosphate, and polyphosphoric acid.

5. The disinfectant according to claim 3, characterized in that: The stabilizer is maleic acid-acrylic acid copolymer.

6. The disinfectant according to claim 5, characterized in that: The molecular weight of the maleic acid-acrylic acid copolymer is not greater than 400.

7. The disinfectant according to claim 1, characterized in that: In the synergist, the molar ratio of chitosan to silver ions is 2-4:

1.

8. The disinfectant according to claim 1, characterized in that: The preparation method of the synergist comprises: adding chitosan into a silver bromide solution, stirring and dissolving, and then reacting at 80-90° C. for 0.5-2 hours to obtain a chelate of chitosan and silver bromide.

9. The disinfectant according to claim 1, characterized in that: The surfactant is at least one of a cationic surfactant and an anionic surfactant.

10. A method for preparing the disinfectant according to any one of claims 1 to 9, characterized in that: The following steps are involved: (1) adding alcohol and a stabilizer to an aqueous hydrogen peroxide solution, stirring and mixing to obtain a mixed solution A; (2) adding a synergist and a surfactant to the mixed solution A and stirring the mixture to obtain a mixed solution B; (3) Add water to the mixed solution B to adjust the concentration to obtain a disinfectant solution.

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