Medical intermediate crushing and grinding device

Abstract

The invention relates to the technical field of pharmaceutical equipment, in particular to a medical intermediate crushing and grinding device which comprises a leakage bin, a crushing device is detachably connected to the bottom of the leakage bin, a grinding bin fixedly penetrates through the upper surface of the side, away from the leakage bin, of the crushing device, and a centrifugal machine fixedly penetrates through the top of the grinding bin. A powder collector is fixedly arranged on the side, away from the material leakage bin, of the centrifugal machine in a penetrating mode, a feeding roller used for conveying intermediates is arranged at the bottom of the inner side of the material leakage bin, a grinding roller used for grinding the intermediates is arranged in the grinding bin, and a rotary downward-pressing propelling mechanism is arranged on the upper surface of the material leakage bin. And through transverse movement of the rack, the ramming and pressing rod can transversely rotate when moving up and down, so that when intermediates with different sizes are placed in the material leakage bin, the ramming and pressing rod can rotate to push materials downwards, and the intermediates with different sizes can be better dispersed and arranged in the material leakage bin through the rotary extrusion effect of the pressure guide roller.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceutical equipment, in particular to a pharmaceutical intermediate crushing and grinding device. Background Art

[0002] In the rapidly developing pharmaceutical industry, pharmaceutical intermediates are becoming increasingly important as the key link between starting materials and final drug products. Pharmaceutical intermediates are an indispensable part of the drug synthesis process. They are gradually transformed into drug molecules with specific pharmacological activities through a series of complex chemical reactions. The quality and performance of intermediates directly affect the safety of the final drug products. These intermediates often need to be finely crushed and ground to achieve a specific particle size distribution and physical form, so as to ensure that they can participate evenly and efficiently in subsequent synthetic reactions, and ultimately generate high-quality drug products. Existing crushing and grinding devices send the intermediates into a crushing chamber for preliminary crushing, and then send the crushed small pieces of intermediates into a grinding chamber for more refined grinding, and finally obtain the intermediates used in drug fusion.

[0003] It can be seen from the above-mentioned crushing and grinding device that there are still the following defects:

[0004] 1. Pharmaceutical intermediates are produced by chemical reaction crystallization. Due to the morphological differences of raw material particles, the intermediates produced by subsequent crystallization are prone to be inconsistent in size. When these intermediates of inconsistent size are put into the leakage chamber, the uneven falling speed of the intermediates will affect the material feeding speed. When the intermediates put in are relatively large pieces, they are easy to get stuck in the pipeline of the leakage chamber, causing material blockage, affecting the subsequent material flow, and the staff are required to use tools to clear the materials stuck in the pipeline. During the clearing process, the bottom of the tool is easy to be drawn into the equipment, causing equipment damage;

[0005] 2. After the intermediate is ground in the grinding chamber, the blades inside the centrifuge rotate to bring the material out of the grinding chamber. Due to the differences in the physical properties and grinding requirements of different intermediates, when the material that does not require such high grinding precision is ground, the material is large in particle size and heavy in weight, which causes the centrifuge to be unable to bring the material out of the grinding chamber when it rotates, making it easy for the material to be over-ground in the grinding chamber, affecting the final quality of the product, and also causing the size of the intermediate to change, exceeding the specified tolerance range, affecting the assembly and performance of the product;

[0006] Therefore, the present invention provides a pharmaceutical intermediate crushing and grinding device to make up for and improve the deficiencies of the prior art. Summary of the invention

[0007] In view of the defects existing in the prior art, the present invention provides a pharmaceutical intermediate crushing and grinding device, which can effectively solve the corresponding technical problems raised in the above background technology.

[0008] To achieve the above objectives, the present invention is implemented through the following technical solutions:

[0009] The invention discloses a pharmaceutical intermediate crushing and grinding device, comprising a leakage cabin, the bottom of the leakage cabin is detachably connected with a crushing device, the upper surface of the crushing device on the side away from the leakage cabin is fixedly penetrated with a grinding cabin, the top of the grinding cabin is fixedly penetrated with a centrifuge, the side of the centrifuge away from the leakage cabin is fixedly penetrated with a powder collector, the bottom of the inner side of the leakage cabin is provided with a feeding roller for transmitting intermediates, the inside of the grinding cabin is provided with a grinding roller for grinding intermediates, the upper surface of the leakage cabin is provided with a rotating downward pressing and propelling mechanism, and the bottom of the inner side of the grinding cabin is provided with a floating rotating grinding mechanism;

[0010] The rotary downward pressing propulsion mechanism is used to rotate and press the intermediate body downward to send it to the bottom of the leakage cabin;

[0011] The floating rotary grinding mechanism is used to dynamically control the grinding accuracy.

[0012] Preferably, a sealing plate is detachably connected to the upper surface of the leakage bin, an L-shaped plate is fixedly connected to the upper surface of the sealing plate, a trapezoidal slide rail is provided on the side of the L-shaped plate close to the center of the sealing plate, the top of the L-shaped plate away from the center of the sealing plate is rotatably connected to a first rocker arm, the top of the first rocker arm close to the L-shaped plate side passes through the surface of the L-shaped plate and is fixedly connected thereto, the top of the rotating bar away from the first rocker arm side is rotatably connected to a sliding plate, and the outer surface of the sliding plate is slidably connected to a U-shaped ring.

[0013] Preferably, a sliding block is fixedly connected to the center of the bottom of the U-shaped ring, the side of the sliding block close to the L-shaped plate is slidably connected to a trapezoidal sliding groove opened on the surface of the L-shaped plate, and the side of the sliding block away from the L-shaped plate is fixedly connected to a fixing ring.

[0014] Preferably, a tamping rod is clamped on the inner side of the fixed ring, the bottom of the tamping rod passes through the lower surface of the sealing plate, the outer surface of the tamping rod away from the sealing plate is fixedly connected to a gear, the outer surface of the gear is meshed with a rack, the side of the rack away from the gear is slidably connected to the center of the sliding block close to the fixed ring, the inner part of the rack away from the sliding block is slidably connected to a limiting rod, and the top of the limiting rod is fixedly connected to the surface of the fixed ring.

[0015] Preferably, the outer surface of the bottom of the grinding chamber is rotatably connected to a second rocker arm, the outer surface of the second rocker arm close to the grinding chamber is rotatably connected to a fixed frame, the side of the fixed frame away from the second rocker arm is fixedly connected to a servo motor, the output transmission of the servo motor is connected to a synchronous belt, the output shaft of the servo motor is connected to a rotating disk via a synchronous belt transmission, and the interior of the rotating disk is rotatably connected to the outer surface of the top of the fixed frame.

[0016] Preferably, a cylindrical sleeve is symmetrically fixedly connected to the upper surface of the rotating disk, a hammer disk is slidably connected to the interior of the cylindrical sleeve, and the outer surface of the hammer disk fits the interior of the grinding chamber.

[0017] Preferably, the second rocker arm is fixedly connected to a first conical wheel at one end close to the outer surface of the grinding chamber, the outer surface of the first conical wheel is meshed with a second conical wheel, the outer surface of the top of the second conical wheel is rotatably connected to the inner side of the fixed frame, the top of the second conical wheel is fixedly connected to a threaded rod, and the outer surface of the threaded rod is threadedly connected to a square cylinder.

[0018] Preferably, the lower surface of the square tube is in contact with the upper surface of the fixing frame, the upper surface of the square tube is rotatably connected to the center of the lower surface of the hammer disk, the outer surface of the square tube is slidably connected to the support frame, and the bottom of the support frame is fixedly connected to the upper surface of the fixing frame.

[0019] Compared with the known public technology, the technical solution provided by the present invention has the following beneficial effects:

[0020] 1. The present invention drives the tamping rod to move up and down by rotating the first rocker, and moves laterally through the rack, so that the tamping rod can also rotate laterally when moving up and down, so that when intermediates of different sizes are placed in the leakage chamber, the tamping rod can be rotated to push the materials downward, and the rotating extrusion effect of the tamping rod can make the intermediates of different sizes better dispersed and arranged in the leakage chamber, so that the discharge of the leakage chamber is smoother, and for larger materials stuck in the pipeline of the leakage chamber, the extrusion of the tamping rod can cause them to be initially crushed and reduce the particle size, creating more favorable conditions for the subsequent grinding process, which can not only improve the grinding efficiency but also reduce energy consumption.

[0021] 2. The present invention drives the hammer disk to rotate in the grinding chamber by rotating the servo motor, and can also change the height of the hammer disk rotating in the grinding chamber by rotating the second rocker. Therefore, when larger particles of material are needed, the hammer disk can be moved upward, so that the ground materials can be taken out of the grinding chamber faster when the centrifuge rotates, avoiding excessive grinding of the materials in the grinding chamber and affecting the material performance. When processing materials that require smaller particles, the hammer disk can be moved downward to keep the materials away from the centrifuge, so that the materials can be ground more finely inside the grinding chamber and will be taken out of the centrifuge only when the grinding requirements are met. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The invention is further described with reference to the embodiments illustrated with the aid of the following drawings, in which:

[0023] Figure 1 It is a schematic diagram of the main stereoscopic structure of the present invention;

[0024] Figure 2 It is a cross-sectional schematic diagram of the internal structure of the main body of the present invention;

[0025] Figure 3 It is a partial schematic diagram of the rotary downward pressing propulsion mechanism of the present invention;

[0026] Figure 4 It is an overall schematic diagram of the other side of the rotary downward pressing propulsion mechanism of the present invention;

[0027] Figure 5 It is a schematic diagram of the overall structure of the floating rotary grinding mechanism of the present invention;

[0028] Figure 6 It is a schematic diagram of the partial structure of the other side of the floating rotary grinding mechanism of the present invention;

[0029] Figure 7 It is a schematic diagram of another state of the floating rotary grinding mechanism of the present invention.

[0030] The numbers in the figure represent:

[0031] 1. Leakage chamber; 11. Crushing device; 12. Grinding chamber; 13. Centrifuge; 14. Powder collector;

[0032] 2. Rotating downward pressing and pushing mechanism; 21. Sealing plate; 211. L-shaped plate; 212. First rocker; 213. Rotating bar; 214. Sliding plate; 215. U-shaped ring; 22. Sliding block; 221. Fixed ring; 222. Ramming rod; 223. Gear; 224. Rack; 225. Limiting rod;

[0033] 3. Floating rotating grinding mechanism; 31. Second rocker; 311. Fixed frame; 312. Servo motor; 313. Rotating disk; 314. Cylindrical sleeve; 315. Hammering disk; 32. First conical wheel; 321. Second conical wheel; 322. Threaded rod; 323. Square cylinder; 324. Support frame. DETAILED DESCRIPTION

[0034] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] The present invention will be further described below in conjunction with the embodiments.

[0036] Embodiments of the present invention

[0037] refer to Figure 1 and Figure 2 As shown, a pharmaceutical intermediate crushing and grinding device comprises a leakage cabin 1, a crushing device 11 is detachably connected to the bottom of the leakage cabin 1, a grinding cabin 12 is fixedly penetrated on the upper surface of the crushing device 11 on the side away from the leakage cabin 1, a centrifuge 13 is fixedly penetrated on the top of the grinding cabin 12, a powder collector 14 is fixedly penetrated on the side of the centrifuge 13 away from the leakage cabin 1, a feeding roller for conveying intermediates is arranged at the bottom of the inner side of the leakage cabin 1, a grinding roller for grinding intermediates is arranged inside the grinding cabin 12, a rotating downward pressing propulsion mechanism 2 is arranged on the upper surface of the leakage cabin 1, and a floating rotating grinding mechanism 3 is arranged at the bottom of the inner side of the grinding cabin 12;

[0038] The rotary downward pressing and pushing mechanism 2 is used to rotate and press the intermediate body downward to send it to the bottom of the leakage chamber 1;

[0039] The floating rotary grinding mechanism 3 is used to dynamically control the grinding accuracy.

[0040] refer to Figure 3 and Figure 4As shown, a pharmaceutical intermediate crushing and grinding device, the upper surface of the leakage chamber 1 is detachably connected with a sealing plate 21, the upper surface of the sealing plate 21 is fixedly connected with an L-shaped plate 211, a trapezoidal slide rail is provided on the side of the L-shaped plate 211 close to the center of the sealing plate 21, the top of the L-shaped plate 211 away from the center of the sealing plate 21 is rotatably connected with a first rocker 212, the top of the first rocker 212 close to the L-shaped plate 211 side passes through the surface of the L-shaped plate 211 and is fixedly connected with a rotating bar 213, the top of the rotating bar 213 away from the first rocker 212 side is rotatably connected with a sliding plate 214, and the outer surface of the sliding plate 214 is slidably connected with a U-shaped ring 215.

[0041] Among them, a sliding block 22 is fixedly connected to the center of the bottom of the U-shaped ring 215, and the side of the sliding block 22 close to the L-shaped plate 211 is slidably connected to the trapezoidal slide groove opened on the surface of the L-shaped plate 211, and the side of the sliding block 22 away from the L-shaped plate 211 is fixedly connected to the fixing ring 221, and the inner side of the fixing ring 221 is clamped with a tamping rod 222, and the bottom of the tamping rod 222 passes through the lower surface of the sealing plate 21, and the outer surface of the tamping rod 222 away from the sealing plate 21 is fixedly connected to a gear 223, and the outer surface of the gear 223 is meshed with a rack 224, and the side of the rack 224 away from the gear 223 is slidably connected to the center of the sliding block 22 close to the fixing ring 221, and the inner side of the rack 224 away from the sliding block 22 is slidably connected to the limiting rod 225, and the top of the limiting rod 225 is fixedly connected to the surface of the fixing ring 221.

[0042] The effects of this embodiment are as follows: In the prior art, pharmaceutical intermediates are produced by chemical reaction crystallization. Due to the morphological differences in the raw material particles, the intermediates produced by subsequent crystallization are prone to be inconsistent in size. When these intermediates of inconsistent sizes are put into the leakage chamber 1, the uneven falling speed of the intermediates will affect the material discharge speed, and when the intermediates put in are relatively large pieces, they are also easy to get stuck in the pipeline of the leakage chamber 1, causing material blockage, affecting the subsequent material flow. Compared with the prior art, the tamping rod 222 is driven to move up and down by rotating the first rocker 212, and the rack 224 moves horizontally, so that the tamping rod 222 can also rotate horizontally when moving up and down, so that when intermediates of different sizes are put into the leakage chamber 1, the tamping rod 222 can be rotated to push the material downward, and the rotating extrusion action of the tamping rod 222 can make the intermediates of different sizes better dispersed and arranged in the leakage chamber 1, so that the material discharge of the leakage chamber is smoother.

[0043] refer to Figures 5 to 7As shown, a pharmaceutical intermediate crushing and grinding device, the outer surface of the bottom of the grinding chamber 12 is rotatably connected to the second rocker 31, the outer surface of the second rocker 31 close to the grinding chamber 12 is rotatably connected to the fixed frame 311, the fixed frame 311 is fixedly connected to the side away from the second rocker 31 with a servo motor 312, the output transmission of the servo motor 312 is connected to a synchronous belt, the output shaft of the servo motor 312 is connected to a rotating disk 313 through a synchronous belt transmission, the interior of the rotating disk 313 is rotatably connected to the outer surface of the top of the fixed frame 311, the upper surface of the rotating disk 313 is symmetrically fixedly connected to a cylindrical sleeve 314, the interior of the cylindrical sleeve 314 is slidably connected to a hammer disk 315, and the outer surface of the hammer disk 315 fits the interior of the grinding chamber 12.

[0044] Among them, the end of the second rocker arm 31 close to the outer surface of the grinding chamber 12 is fixedly connected to the first conical wheel 32, the outer surface of the first conical wheel 32 is meshed with the second conical wheel 321, the outer surface of the top of the second conical wheel 321 is rotatably connected to the inner side of the fixed frame 311, the top of the second conical wheel 321 is fixedly connected to the threaded rod 322, the outer surface of the threaded rod 322 is threadedly connected to the square cylinder 323, the lower surface of the square cylinder 323 is fitted with the upper surface of the fixed frame 311, the upper surface of the square cylinder 323 is rotatably connected to the center of the lower surface of the hammer disk 315, the outer surface of the square cylinder 323 is slidably connected to the support frame 324, and the bottom of the support frame 324 is fixedly connected to the upper surface of the fixed frame 311.

[0045] The effects of this embodiment are as follows: In the prior art, after the intermediate is ground in the grinding chamber 12, the blades inside the centrifuge 13 rotate to bring the material out of the grinding chamber 12. Due to the differences in the physical properties and grinding requirements of different intermediates, when the material that does not require such a high grinding accuracy is ground, the material is large in particle size and heavy in weight, resulting in the inability of the centrifuge 13 to bring the material out of the grinding chamber 12 when it rotates, making it easy for the material to be over-ground in the grinding chamber 12, affecting the final quality of the product. Compared with the prior art, the hammer disk 315 is driven to rotate in the grinding chamber 12 by the rotation of the servo motor 312, and the height of the hammer disk 315 rotating in the grinding chamber 12 can be changed by rotating the second rocker 31, so that when grinding materials that require larger particles, the hammer disk 315 can be moved upward, so that when the centrifuge 13 rotates, the ground materials can be brought out of the grinding chamber 12 faster, avoiding excessive grinding of the materials in the grinding chamber 12 and affecting the material performance.

[0046] The complete working principle and steps of the above embodiment are as follows:

[0047] Rotate and push forward steps:

[0048] like Figure 3 and Figure 4As shown, when the crushing and grinding equipment is in the initial state, the feed roller at the bottom of the inner side of the leakage chamber 1, the crushing device 11 and the grinding roller inside the grinding chamber 12 are all in a closed state, the sliding plate 214 is slidably connected to the middle part of the inner side of the U-shaped ring 215, the side of the sliding block 22 away from the fixed ring 221 is slidably connected to the top of the trapezoidal groove on the surface of the L-shaped plate 211, the outer surface of the gear 223 is meshed with the side of the rack 224 close to the sliding block 22, and the bottom of the tamping rod 222 is in a retracted state;

[0049] When the staff uses the crushing and grinding device, they first start the feeding roller and crushing device 11 at the bottom inner side of the leakage chamber 1, and then the staff puts the block-shaped intermediate into the upper surface of the leakage chamber 1, and the material will slide to the bottom along the inner side of the leakage chamber 1. When the material is blocked in the pipeline of the leakage chamber 1, the staff can rotate the first rocker 212 connected to the surface of the L-shaped plate 211. As the first rocker 212 rotates 180 degrees, it drives the rotating bar 213 fixedly connected to the top of the first rocker 212 to rotate at the same time. As the rotating bar 213 rotates 180 degrees, it drives the sliding plate 214 connected to the top of the rotating bar 213 to slide on the inner side of the U-shaped ring 215, and drives the U-shaped ring 215 to move downward. The center of the bottom of the U-shaped ring 215 is fixedly connected to the top of the sliding block 22. As the U-shaped ring 215 moves downward, it drives the sliding block 22 to move in the trapezoidal slide groove provided on the surface of the L-shaped plate 211. The inner side of the fixing ring 221 is clamped on the outer surface of the tamping rod 222, and the tamping rod 222 is driven downwardly to make the bottom of the tamping rod 222 extend into the inner side of the leakage chamber 1. The rotation of the first rocker arm 212 can drive the tamping rod 222 to reciprocate inside the leakage chamber 1, so as to prevent the accumulation of materials in the leakage chamber 1, maintain the fluidity of the materials, and speed up the inflow of the materials, which is conducive to the smooth progress of the subsequent processes. The sealing plate 21 detachably connected to the upper surface of the leakage chamber 1 can effectively prevent the dust from floating out when the materials enter the leakage chamber 1. The sealing plate 21 can also effectively isolate the dust and impurities in the external environment from entering the leakage chamber 1, thereby protecting the intermediate from external pollution.

[0050] Compared with the manual dredging in the prior art, when manual dredging is performed with tools, sufficient force is required to push the intermediate body downward, and when the material is squeezed downward, it is easy to cause the tool to be inserted into the bottom of the leakage chamber 1 at the same time, so that the tool is rolled into the bottom of the leakage chamber 1, causing damage to the internal part of the equipment and easily causing danger to the staff. The tamping rod 222 can be continuously connected and reciprocated downward to dredge, and the tamping rod 222 will not be rolled in when it moves to the bottom of the leakage chamber 1, and the sliding block 22 will not cause damage to the outer shell and inner wall of the leakage chamber 1 when it moves up and down. In addition, when the tamping rod 222 moves up and down, there is no need to open the sealing plate 21 to continuously dredge the inside of the leakage chamber 1, which can avoid the dust of the material from floating out during dredging and the entry of harmful impurities.

[0051] Moreover, as the sliding block 22 slides downward, it also drives the rack 224 slidably connected to the inner side of the sliding block 22 to slide simultaneously, and the side of the rack 224 away from the gear 223 is slidably connected to the outer surface of the limiting rod 225, and the limiting rod 225 is in an inclined state. As the rack 224 moves downward, it causes the rack 224 to slide toward the side close to the sliding block 22, and the side of the rack 224 away from the sliding block 22 is meshed with the outer surface of the gear 223. As the rack 224 is pushed toward the side close to the sliding block 22, it causes the rack 224 to drive the gear 223 to rotate, and when the gear 223 rotates, it drives the fixed connection At the same time, the tamping rod 222 inside the gear 223 rotates, causing the tamping rod 222 to rotate and press downward when pressing down. When encountering larger materials stuck in the leakage chamber 1, the rotating extrusion of the tamping rod 222 can cause them to be initially crushed and reduce the particle size, so that the materials can easily pass through the leakage chamber 1, creating more favorable conditions for the subsequent grinding process. This not only improves the grinding efficiency but also reduces energy consumption. At this time, the crushing device 11 and the grinding rollers inside the grinding chamber 12 are started again. At this time, after the materials are initially crushed inside the crushing device 11, they enter the grinding chamber 12 through the pipe on the upper surface of the crushing device 11 for more refined grinding.

[0052] Floating rotation steps:

[0053] like Figures 5 to 7 As shown, when the crushing and grinding equipment is in the initial state, the servo motor 312 is in the off state, the bottom of the hammer plate 315 is slidably connected to the bottom of the inner side of the cylindrical sleeve 314, and the inner side of the support frame 324 is slidably connected to the top of the square cylinder 323;

[0054] As the material is ground by the grinding roller inside the grinding chamber 12, small particles of the material will fall onto the upper surface of the hammer disk 315. At this time, the staff starts the servo motor 312 fixedly connected to the right side of the fixed frame 311. As the servo motor 312 is started, the synchronous belt on the outer surface of the output shaft of the servo motor 312 drives the rotating disk 313 to rotate at the same time, and the upper surface of the rotating disk 313 is fixedly connected to the bottom of the cylindrical sleeve 314. As the rotating disk 313 rotates, the cylindrical sleeve 314 is driven to rotate at the same time. The cylindrical sleeve 314 rotates, and the hammer disc 315 slidably connected to the cylindrical sleeve 314 rotates simultaneously, causing the hammer disc 315 to rotate inside the grinding chamber 12. At this time, since the material is spilled onto the upper surface of the hammer disc 315, the hammer disc 315 will throw the material onto the inner wall of the grinding chamber 12 due to the centrifugal force when the hammer disc 315 rotates. When the centrifuge 13 on the upper surface of the grinding chamber 12 is started, the ground material is sent from the inside of the grinding chamber 12 into the powder collector by the suction of the centrifuge 13. 14, and when the material grinding requires larger particles, the staff can rotate the second rocker 31 on the outer surface of the grinding chamber 12. As the second rocker 31 rotates, the first conical wheel 32 is driven to rotate at the same time. As the first conical wheel 32 rotates, the second conical wheel 321 meshed with the outer surface of the first conical wheel 32 is driven to rotate at the same time on the inner side of the fixed frame 311, and the upper surface of the second conical wheel 321 passes through the top of the fixed frame 311 and is fixedly connected to the bottom of the threaded rod 322. At this time, when the second conical wheel 321 rotates, it will drive the threaded rod 322 to rotate at the same time. When the threaded rod 322 rotates, it will drive the square cylinder 323 threadedly connected to the outer surface of the threaded rod 322 to move toward the top, so that the outer surface of the square cylinder 323 slides toward the top on the inner side of the support frame 324, driving the hammer plate 315 connected to the top of the square cylinder 323 to slide upward at the same time, so that the hammer plate 315 slides upward when it rotates, so that the large particles of material after grinding are more easily taken out by the centrifuge 13.

[0055] When the intermediate needs to obtain larger grinding particles, the hammer disk 315 can be moved upward to make the upper surface of the hammer disk 315 closer to the centrifuge 13, and the volume inside the grinding chamber 12 will gradually decrease. At this time, the centrifuge 13 can drive these materials with larger particle sizes to be discharged from the grinding chamber 12 more quickly to avoid excessive grinding of these materials in the grinding chamber 12 to affect the material performance. When processing intermediates with smaller particle sizes, the hammer disk 315 can be moved downward to make the upper surface of the hammer disk 315 away from the centrifuge 13, and the volume inside the grinding chamber 12 will increase accordingly. Since the distance between the centrifuge 13 and the hammer disk 315 increases, the large particles of material are heavier and will not be driven by the centrifuge 13. Only the materials that meet the grinding requirements will be taken out by the centrifuge 13. By adjusting the height and rotation speed of the hammer disk 315, the flow speed and grinding time of the material inside the grinding chamber 12 can be accurately controlled, thereby achieving fine and precise grinding of materials with different particle size requirements.

[0056] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. Such modifications or replacements will not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A pharmaceutical intermediate crushing and grinding device, comprising a leakage chamber (1), the bottom of the leakage chamber (1) is detachably connected to a crushing device (11), the upper surface of the crushing device (11) on the side away from the leakage chamber (1) is fixedly penetrated by a grinding chamber (12), the top of the grinding chamber (12) is fixedly penetrated by a centrifuge (13), and the side of the centrifuge (13) away from the leakage chamber (1) is fixedly penetrated by a powder collector (14), characterized in that: A feeding roller for conveying the intermediate is arranged at the bottom of the inner side of the leakage chamber (1), a grinding roller for grinding the intermediate is arranged inside the grinding chamber (12), a rotating downward pressing propulsion mechanism (2) is arranged on the upper surface of the leakage chamber (1), and a floating rotating grinding mechanism (3) is arranged at the bottom of the inner side of the grinding chamber (12); The rotary downward pressing and pushing mechanism (2) is used to rotate and push the intermediate body downward into the bottom of the leakage chamber (1); The floating rotary grinding mechanism (3) is used to dynamically control the grinding accuracy.

2. A pharmaceutical intermediate crushing and grinding device according to claim 1, characterized in that: The upper surface of the leakage chamber (1) is detachably connected to a sealing plate (21), and the upper surface of the sealing plate (21) is fixedly connected to an L-shaped plate (211), and a trapezoidal sliding groove is provided on a side of the L-shaped plate (211) close to the center of the sealing plate (21), and a first rocking arm (212) is rotatably connected to the top of the side of the L-shaped plate (211) away from the center of the sealing plate (21), and a rotating bar (213) is fixedly connected to the surface of the L-shaped plate (211) at the top of the side of the first rocking arm (212) close to the L-shaped plate (211), and the rotating bar (213) is rotatably connected to a sliding plate (214) at the top of the side away from the first rocking arm (212), and a U-shaped ring (215) is slidably connected to the outer surface of the sliding plate (214).

3. A pharmaceutical intermediate crushing and grinding device according to claim 2, characterized in that: A sliding block (22) is fixedly connected at the center of the bottom of the U-shaped ring (215); a side of the sliding block (22) close to the L-shaped plate (211) is slidably connected to a trapezoidal sliding groove provided on the surface of the L-shaped plate (211); and a side of the sliding block (22) away from the L-shaped plate (211) is fixedly connected to a fixing ring (221).

4. A pharmaceutical intermediate crushing and grinding device according to claim 3, characterized in that: A tamping rod (222) is clamped on the inner side of the fixing ring (221), the bottom of the tamping rod (222) passes through the lower surface of the sealing plate (21), the outer surface of the tamping rod (222) away from the sealing plate (21) is fixedly connected with a gear (223), the outer surface of the gear (223) is meshed with a rack (224), the side of the rack (224) away from the gear (223) is slidably connected to the center of the sliding block (22) close to the fixing ring (221), the inner side of the rack (224) away from the sliding block (22) is slidably connected to a limiting rod (225), the top of the limiting rod (225) is fixedly connected to the surface of the fixing ring (221).

5. The pharmaceutical intermediate crushing and grinding device according to claim 1, characterized in that: The outer surface of the bottom of the grinding chamber (12) is rotatably connected to a second rocking arm (31); the outer surface of the second rocking arm (31) on a side close to the grinding chamber (12) is rotatably connected to a fixed frame (311); a side of the fixed frame (311) away from the second rocking arm (31) is fixedly connected to a servo motor (312); the output shaft of the servo motor (312) is transmission-connected to a synchronous belt; the output shaft of the servo motor (312) is transmission-connected to a rotating disk (313) via a synchronous belt; the rotating disk (313) is rotationally connected to the outer surface of the top of the fixed frame (311) internally.

6. The pharmaceutical intermediate crushing and grinding device according to claim 5, characterized in that: The upper surface of the rotating disk (313) is symmetrically fixedly connected with a cylindrical sleeve (314), the interior of the cylindrical sleeve (314) is slidably connected with a hammer disk (315), and the outer surface of the hammer disk (315) fits the interior of the grinding chamber (12).

7. The pharmaceutical intermediate crushing and grinding device according to claim 6, characterized in that: One end of the second rocker arm (31) close to the outer surface of the grinding chamber (12) is fixedly connected to the first conical wheel (32); the outer surface of the first conical wheel (32) is meshed with the second conical wheel (321); the outer surface of the top of the second conical wheel (321) is rotatably connected to the inner side of the fixed frame (311); the top of the second conical wheel (321) is fixedly connected to a threaded rod (322); the outer surface of the threaded rod (322) is threadedly connected to a square cylinder (323).

8. The pharmaceutical intermediate crushing and grinding device according to claim 7, characterized in that: The lower surface of the square tube (323) is in contact with the upper surface of the fixing frame (311), the upper surface of the square tube (323) is rotatably connected to the center of the lower surface of the hammer plate (315), the outer surface of the square tube (323) is slidably connected to a support frame (324), and the bottom of the support frame (324) is fixedly connected to the upper surface of the fixing frame (311).

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