Ion beam treatment device

Abstract

The invention provides an ion beam treatment device, and relates to the technical field of synchronous accelerators. The ion beam treatment device comprises a synchrotron used for accelerating beam current to obtain preset energy beam current, the synchrotron comprises six unit structures, and each unit structure comprises a dipole magnet, a horizontal focusing quadrupole magnet, a vertical focusing quadrupole magnet and a straight section; wherein the horizontal focusing quadrupole magnet and the vertical focusing quadrupole magnet are arranged on the linear section, and one end of the linear section is connected with the dipole magnet; and the free end of the straight section in each unit structure is connected with the dipolar magnet in the adjacent unit structure, so that the six unit structures form a periodic closed loop.

Description

Technical Field

[0001] The present invention relates to the technical field of synchrotron accelerators, and more particularly to an ion beam therapy device. Background Art

[0002] At present, the synchrotrons used for radiotherapy mainly include proton synchrotrons and heavy ion synchrotrons. These two accelerators play an important role in tumor radiotherapy due to their unique physical properties.

[0003] Proton synchrotrons are mainly used to accelerate protons. The energy of proton beams used for radiotherapy usually does not exceed 230MeV, and the water equivalent range is about 33cm, corresponding to a magnetic rigidity of 2.33Tm. Therefore, when proton synchrotrons used for radiotherapy are used to accelerate other types of ions, they can often only be accelerated to lower energies. For example, for helium ions, when their water equivalent range is about 33cm, the energy must reach 230MeV / u, corresponding to a magnetic rigidity of 4.63Tm; while the energy of helium ions with a magnetic rigidity of 2.33Tm is only 63MeV / u, and the water equivalent range is less than 3.5cm, so their clinical applications are limited.

[0004] Although the existing synchrotrons that can accelerate protons and heavy ions can meet clinical applications, the maximum energy of the accelerated ions is 430MeV / u, and the maximum magnetic stiffness of the accelerated ions is 6.62Tm, the maximum magnetic stiffness of the ions that can be accelerated is high, resulting in a large magnet radius, large size and weight. In addition, when the arrangement of various components is exactly the same, the circumference of the synchrotron is approximately proportional to the maximum magnetic stiffness, which is about 40% longer than the length required for the light ion synchrotron. The space cannot be effectively utilized, and the flexibility and portability of the equipment are limited. Summary of the invention

[0005] In view of this, the present invention provides an ion beam therapy device.

[0006] The present invention provides an ion beam therapy device, comprising a synchrotron, for accelerating a beam to obtain a preset energy beam: the synchrotron comprises six unit structures, each unit structure comprises a dipole magnet, a horizontal focusing quadrupole magnet, a vertical focusing quadrupole magnet and a linear segment; wherein the horizontal focusing quadrupole magnet and the vertical focusing quadrupole magnet are arranged on the linear segment, and one end of the linear segment is connected to the dipole magnet; the free end of the linear segment in a single unit structure is connected to the dipole magnet in an adjacent unit structure, so that the six unit structures form a periodic closed loop.

[0007] According to an embodiment of the present invention, in a periodic closed loop, starting from the beam injection point along the direction of beam transmission, the straight line segments are, in sequence, the injection straight line segment, the post-injection straight line segment, the lead-out front straight line segment, the lead-out straight line segment, the post-lead-out straight line segment, and the front-injection straight line segment; wherein the injection straight line segment and the lead-out straight line segment are symmetrical straight line segments.

[0008] According to an embodiment of the present invention, the synchrotron accelerator further comprises: six sextupole magnets, each sextupole magnet being arranged between the horizontal focusing quadrupole magnet and the dipole magnet; a correction magnet being arranged at one end of the vertical focusing quadrupole magnet on each linear segment away from the dipole magnet and one end of the horizontal focusing quadrupole magnet on the post-injection linear segment, the post-extraction linear segment and the pre-injection linear segment away from the sextupole magnet, for correcting the orbit of the beam; a position probe being arranged at one end of the vertical focusing quadrupole magnet on each linear segment away from the dipole magnet and one end of the horizontal focusing quadrupole magnet on the injection linear segment, the post-injection linear segment, the pre-extraction linear segment, the post-extraction linear segment and the pre-injection linear segment away from the sextupole magnet, for detecting the orbit of the beam.

[0009] According to the embodiments of the present invention, the correction magnets arranged on the injection straight line segment, the straight line segment after injection, the straight line segment before lead-out, and the end of the vertical focusing quadrupole magnet on the lead-out straight line segment away from the dipole magnet are all bidirectional correction magnets; the correction magnets arranged on the end of the vertical focusing quadrupole magnet on the straight line segment after lead-out and the straight line segment before injection away from the dipole magnet are all vertical correction magnets; the position probes under the bidirectional correction magnets on the injection straight line segment and the straight line segment after injection are all vertical position probes; the position probes under the bidirectional correction magnets on the straight line segment before lead-out and the lead-out straight line segment are all bidirectional position probes; the position probes under the vertical correction magnets on the straight line segment after lead-out and the straight line segment before injection are all vertical position probes.

[0010] According to an embodiment of the present invention, the position probes arranged on the end of the horizontal focusing quadrupole magnet away from the sextupole magnet on the injection straight section, the post-injection straight section, the lead-out front straight section, the lead-out rear straight section and the pre-injection straight section are all horizontal position probes; the correction magnets arranged on the end of the horizontal focusing quadrupole magnet away from the sextupole magnet on the post-injection straight section, the lead-out rear straight section and the pre-injection straight section are all horizontal correction magnets.

[0011] According to an embodiment of the present invention, the synchrotron accelerator further comprises: a high-frequency accelerating cavity, which is arranged on the post-extraction straight section and is used to accelerate or decelerate the beam.

[0012] According to an embodiment of the present invention, the synchrotron accelerator further includes: an injection cutting magnet, which is arranged between the horizontal position probe and the vertical position probe on the injection linear section, and is used to introduce the beam into the synchrotron accelerator; an injection electrostatic cutter, which is arranged between the vertical position probe and the injection cutting magnet on the injection linear section, and is used to give the beam a lateral kick angle so that the beam enters the periodic closed loop acceptance; a plurality of injection cam magnets, which are arranged on the injection linear section, the post-injection linear section and the pre-injection linear section, and are used to form a local cam at the injection electrostatic cutter and to complete the beam injection by controlling the strength of a plurality of injection cam magnets.

[0013] According to an embodiment of the present invention, the synchrotron accelerator further includes: an extraction electrostatic cutter, which is arranged between the horizontal position probe and the bidirectional position probe on the extraction front straight section, and is used to provide a lateral kick angle for the preset energy beam so as to cut and separate the preset energy beam; a plurality of extraction cutting magnets, which are arranged at one end of the horizontal focusing quadrupole magnet on the extraction straight section away from the sextupole magnet, and are used to extract the preset energy beam that has been cut and separated.

[0014] According to an embodiment of the present invention, it also includes: an extraction lateral excitation, which is arranged on any one of the straight segments and is used to excite the lateral vibration of the preset energy beam, so that the preset energy beam enters the unstable area to be extracted; a plurality of extraction convex rail magnets, which are arranged on the straight segment after injection, the straight segment before extraction and the extraction straight segment, and are used to form a local convex rail at the extraction electrostatic cutter to make the preset energy beam close to the pole plate of the extraction electrostatic cutter.

[0015] According to an embodiment of the present invention, the ion beam cancer treatment device further includes: an ion source for providing low-energy ions; the ion source includes a proton source, a helium ion source and a carbon ion source.

[0016] According to an embodiment of the present invention, six unit structures are designed to be connected to form a periodic closed loop, so that the influence of nonlinear resonance on the synchrotron accelerator is reduced, thereby reducing beam loss and improving beam stability. At the same time, by optimizing the equipment layout, the utilization rate of the space is effectively improved and the circumference of the synchrotron accelerator is reduced.

[0017] According to the embodiments of the present invention, the ion source can provide protons and heavy ions, solving the existing clinical limitations. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The above and other objects, features and advantages of the present invention will become more apparent through the following description of the embodiments of the present invention with reference to the accompanying drawings, in which:

[0019] Figure 1 The structural diagram of a synchrotron according to an embodiment of the present invention is schematically shown.

[0020] Figure 2 Schematically illustrates an envelope function of a synchrotron according to an embodiment of the present invention;

[0021] Figure 3 Schematically showing the dispersion function of a synchrotron according to an embodiment of the present invention;

[0022] Figure 4 A schematic diagram showing the positions of a position probe and a calibration magnet according to an embodiment of the present invention;

[0023] Figure 5 A beam injection trajectory diagram according to an embodiment of the present invention is schematically shown;

[0024] Figure 6 A beam extraction trajectory diagram according to an embodiment of the present invention is schematically shown;

[0025] Figure 7 Schematically shows a schematic diagram of an ion beam therapy device according to an embodiment of the present invention;

[0026] Description of reference numerals:

[0027] 1-1: injection straight section; 1-2: injection rear straight section; 1-3: extraction front straight section; 1-4: extraction straight section; 1-5: extraction rear straight section; 1-6: injection front straight section; 2: dipole magnet; 3-1, 3-2, 3-3, 3-4, 3-5, 3-6: vertical focusing quadrupole magnet; 4-1, 4-2, 4-3, 4-4, 4-5, 4-6: sextupole magnet; 5-1, 5-2, 5-3, 5-4, 5-5, 5-6: horizontal focusing quadrupole magnet; 6-1, 6-2: fast quadrupole magnet; 7: injection cutting magnet; 8: injection electrostatic cutter; 9-1, 9-2: extraction cutting magnet; 10: extraction electrostatic cutter; 11: high frequency acceleration cavity; 12 : Extraction lateral excitation; 13-1, 13-2, 13-3, 13-4: injection bump magnet; 14-1, 14-2, 14-3: extraction bump magnet; 15-1, 15-2, 15-3, 15-4, 15-5, 15-6, 15-7, 15-8, 15-9: correction magnet; 16-1, 16-2, 16-3, 16-4, 16-5, 16-6, 16-7, 16-8, 16-9, 16-10, 16-11: position probe; 17: ion source; 18: Glasser lens; 19: analysis magnet; 20: solenoid coil; 21: radio frequency quadrupole field accelerator; 22: drift tube linear accelerator; 23: stripping film. DETAILED DESCRIPTION

[0028] Below, embodiments of the present invention will be described with reference to the accompanying drawings. However, it should be understood that these descriptions are exemplary only and are not intended to limit the scope of the present invention. In the following detailed description, for ease of explanation, many specific details are set forth to provide a comprehensive understanding of embodiments of the present invention. However, it is apparent that one or more embodiments may also be implemented without these specific details. In addition, in the following description, descriptions of known structures and technologies are omitted to avoid unnecessary confusion of concepts of the present invention.

[0029] The terms used herein are only for describing specific embodiments and are not intended to limit the present invention. The terms "comprise", "include", etc. used herein indicate the existence of the features, steps, operations and / or components, but do not exclude the existence or addition of one or more other features, steps, operations or components.

[0030] All terms (including technical and scientific terms) used herein have the meanings commonly understood by those skilled in the art unless otherwise defined. It should be noted that the terms used herein should be interpreted as having a meaning consistent with the context of this specification and should not be interpreted in an idealized or overly rigid manner.

[0031] When using expressions such as "at least one of A, B, and C, etc.", they should generally be interpreted according to the meaning of the expression commonly understood by those skilled in the art (for example, "a system having at least one of A, B, and C" should include but is not limited to a system having A alone, B alone, C alone, A and B, A and C, B and C, and / or A, B, C, etc.).

[0032] Figure 1 The structural diagram of a synchrotron according to an embodiment of the present invention is schematically shown.

[0033] Figure 2 The envelope function of a synchrotron according to an embodiment of the present invention is schematically shown.

[0034] Figure 3 The dispersion function of a synchrotron according to an embodiment of the present invention is schematically shown.

[0035] like Figure 1 As shown, the present invention provides an ion beam therapy device, including a synchrotron, for accelerating a beam to obtain a preset energy beam: the synchrotron includes six unit structures, each unit structure includes a dipole magnet, a horizontal focusing quadrupole magnet, a vertical focusing quadrupole magnet and a linear segment; wherein the horizontal focusing quadrupole magnet and the vertical focusing quadrupole magnet are arranged on the linear segment, and one end of the linear segment is connected to the dipole magnet; the free end of the linear segment in a single unit structure is connected to the dipole magnet in an adjacent unit structure, so that the six unit structures form a periodic closed loop.

[0036] In an embodiment of the present invention, the working point It is defined as the value of the transverse motion frequency divided by the cyclotron frequency. In the accelerator, the actual transverse motion frequency of each individual particle will be different from the operating point due to factors such as energy deviation and space charge effect. When the operating point meets certain conditions, that is, there are integer coefficients m, n and , so that When , and there is a high-order field of the corresponding order in the synchronous ring magnet, the motion of the beam will undergo nonlinear resonance, resulting in an increase in the beam emittance and envelope, thus causing beam loss. When the value is an integer multiple of the period of the synchronization ring structure, it is called system resonance, otherwise it is called random resonance. In general, the selection of the working point should avoid system resonance to reduce beam loss and improve beam stability. And from the conditions of system resonance, it can be seen that when the number of synchronization ring periods is more, the system resonance will be less. For a periodic closed loop with a period of 2, it is a system resonance, while for a periodic closed loop with a period of 6, it is a random resonance. Therefore, the periodic closed loop with a period of 6 is less affected by nonlinear resonance.

[0037] At the same time, the extraction system of the medical synchrotron requires that the phase shift between the extraction electrostatic cutter and the extraction cutting magnet is close to 90°, and the working point is required to be set near 1.666, corresponding to a total phase shift of 600°. If the period is 6, the phase shift between the cycles is 100°, and the extraction electrostatic cutter and the extraction cutting magnet are placed in adjacent periods, which can meet the design requirements. However, other period numbers such as 8, 10, etc. are more difficult to meet the design requirements.

[0038] Therefore, the present invention effectively improves the stability of the beam, reduces the loss of the beam, and meets the design requirements by designing six unit structures. At the same time, the circumference of the designed synchrotron accelerator does not exceed 40m, compared with the circumference of the current medical heavy ion accelerators in the world that is greater than 56m, the space utilization is improved.

[0039] like Figure 2 and Figure 3 As shown in the figure, the envelope function and dispersion function of the synchrotron in the horizontal and vertical directions. The envelope function and dispersion function jointly determine the lateral size of the beam in the synchrotron. Among them, the rectangular blocks symmetrically located above and below the horizontal axis are dipole magnets, the blocks located above the horizontal axis are horizontal focusing quadrupole magnets, and the blocks located below the horizontal axis are vertical focusing quadrupole magnets.

[0040] According to an embodiment of the present invention, the angles of the dipole magnets in the six unit structures are all 60°, and the lengths of the straight sections are all equal.

[0041] According to an embodiment of the present invention, in a periodic closed loop, starting from the beam injection point along the direction of beam transmission, the straight line segments are, in sequence, an injection straight line segment 1-1, a straight line segment after injection 1-2, a straight line segment before lead-out 1-3, a straight line segment 1-4, a straight line segment after lead-out 1-5, and a straight line segment before injection 1-6; wherein, the injection straight line segment 1-1 and the lead-out straight line segment 1-4 are symmetrical straight line segments.

[0042] In the embodiment of the present invention, the injection linear segment and the extraction linear segment are designed as symmetrical linear segments, so that the convex track magnets, electrostatic cutters, etc. related to injection and extraction are distributed on different linear segments, and the space is effectively utilized, which is conducive to shortening the length of the linear segment. The injection cutting magnet, extraction electrostatic cutter, extraction cutting magnet of the existing particle accelerator are located on three adjacent linear segments, and the convex track magnets required for the injection and extraction processes are solved, so that the length of the required linear segment is longer. At the same time, the periodic structure of the accelerator also determines that the length of all linear segments must be consistent, so other linear segments must also be lengthened accordingly, which leads to the problem of the overall accelerator circumference becoming longer.

[0043] Figure 4 A diagram schematically illustrates the positions of a position probe and a calibration magnet according to an embodiment of the present invention.

[0044] like Figure 4 As shown, according to an embodiment of the present invention, the synchrotron accelerator also includes: six sextupole magnets 4-1, 4-2, 4-3, 4-4, 4-5 and 4-6, each sextupole magnet being arranged between the horizontal focusing quadrupole magnet and the dipole magnet; a correction magnet being arranged at one end of the vertical focusing quadrupole magnet on each linear segment away from the dipole magnet and one end of the horizontal focusing quadrupole magnet on the post-injection linear segment, the post-extraction linear segment and the pre-injection linear segment away from the sextupole magnet, for correcting the trajectory of the beam; a position probe being arranged at one end of the vertical focusing quadrupole magnet on each linear segment away from the dipole magnet and one end of the horizontal focusing quadrupole magnet on the injection linear segment, the post-injection linear segment, the pre-extraction linear segment, the post-extraction linear segment and the pre-injection linear segment away from the sextupole magnet, for detecting the trajectory of the beam.

[0045] In an embodiment of the present invention, there are one pair of sextupole magnets located on the symmetrical straight line nodes, with a total of three pairs, of which two pairs of sextupole magnets are resonant sextupole magnets, which are used to establish third-order resonance in phase space so that the preset energy beam enters the unstable region from the stable region. The other pair is a chromaticity sextupole magnet, which is used to adjust the chromaticity of the beam so that the beam remains in a stable orbit when the energy fluctuates. When the paired sextupole magnets have the same strength but opposite polarity, beam resonance can be induced without affecting the chromaticity; when the two sextupole magnets have the same strength and the same polarity, the chromaticity can be adjusted without increasing the resonance intensity. By equipping three pairs of sextupole magnets, independent adjustment of chromaticity and resonance intensity can be achieved.

[0046] In the periodic closed loop of the present invention, the maximum value of the track error in the vertical direction is at the vertical focusing quadrupole magnet. By setting a position probe at the vertical focusing quadrupole magnet and correcting the track error detected by the position probe through a correction magnet, the track error at other positions of the periodic closed loop will also reach a minimum value. The arrangement of the correction magnet and the position probe on the vertical focusing quadrupole magnet can effectively reduce the track error in the vertical direction. It also optimizes the layout of the equipment on the linear section, reduces the manufacturing and installation costs of the main components, and at the same time, the compact structure reduces the floor space.

[0047] According to the embodiment of the present invention, the correction magnets 15-1, 15-3, 15-4 and 15-5 arranged on the ends of the vertical focusing quadrupole magnets 3-1, 3-2, 3-3 and 3-4 away from the dipole magnet on the injection straight segment 1-1, the post-injection straight segment 1-2, the lead-out front straight segment 1-3 and the lead-out straight segment 1-4 are all bidirectional correction magnets; the correction magnets 15-1, 15-3, 15-4 and 15-5 arranged on the ends of the vertical focusing quadrupole magnets 3-5 and 3-6 away from the dipole magnet on the lead-out rear straight segment 1-5 and the pre-injection straight segment 1-6 are all bidirectional correction magnets. -7 and 15-9 are both vertical correction magnets; the position probes 16-2 and 16-4 under the bidirectional correction magnets on the injection linear segment 1-1 and the injection rear linear segment 1-2 are both vertical position probes; the position probes 16-6 and 16-7 under the bidirectional correction magnets on the lead-out front linear segment 1-3 and the lead-out linear segment 1-4 are both bidirectional position probes; the position probes 16-9 and 16-11 under the vertical correction magnets on the lead-out rear linear segment 1-5 and the injection front linear segment 1-6 are both vertical position probes.

[0048] In an embodiment of the present invention, the injection straight segment, the lead-out front straight segment and the lead-out straight segment are provided with injection and lead-out related electrostatic cutters, cutting magnets, etc., and the position space of the straight segment is relatively compact. Therefore, a bidirectional position probe and a bidirectional correction magnet are provided to ensure that the horizontal track error is within a smaller range, and the horizontal track error can be assisted in correction by adjusting the field value of the dipole magnet.

[0049] According to an embodiment of the present invention, the position probes 16-1, 16-3, 16-5, 16-8 and 16-10 provided on the ends of the horizontal focusing quadrupole magnets 5-1, 5-2, 5-3, 5-5 and 5-6 on the injection linear segment 1-1, the post-injection linear segment 1-2, the lead-out front linear segment 1-3, the lead-out rear linear segment 1-5 and the pre-injection linear segment 1-6, which are away from the sextuple magnets 4-1, 4-2 and 4-3, 4-5 and 4-6, are all horizontal position probes; the correction magnets 15-2, 15-6 and 15-8 provided on the ends of the horizontal focusing quadrupole magnets 5-2, 5-5 and 5-6 on the post-injection linear segment 1-2, the lead-out rear linear segment 1-5 and the pre-injection linear segment 1-6, which are away from the sextuple magnets 4-2, 4-5 and 4-6, are all horizontal correction magnets.

[0050] In the embodiment of the present invention, the bidirectional position probe and the bidirectional correction magnet mean that the beam trajectory in two directions can be detected or corrected simultaneously.

[0051] According to an embodiment of the present invention, the synchrotron accelerator further comprises: a high-frequency accelerating cavity 11, which is arranged on the post-extraction straight section and is used to accelerate or decelerate the beam.

[0052] In an embodiment of the present invention, the beam in the synchrotron accelerator is first formed into a bunch through high-frequency adiabatic capture. The frequency of the high-frequency accelerating cavity and the magnetic field rising speed are adjusted to keep the periodic motion of the bunch and the periodic change of the accelerating electric field strictly synchronized, so that the bunch can maintain a constant orbit and continue to accelerate or decelerate.

[0053] According to an embodiment of the present invention, the synchrotron further comprises fast quadrupole magnets 6 - 1 and 6 - 2 for rapidly cutting off the beam.

[0054] Figure 5 The beam injection trajectory diagram according to an embodiment of the present invention is schematically shown.

[0055] According to an embodiment of the present invention, the synchrotron accelerator further includes: an injection cutting magnet 7, which is arranged between the horizontal position probe and the vertical position probe on the injection linear section, and is used to introduce the beam into the synchrotron accelerator; an injection electrostatic cutter 8, which is arranged between the vertical position probe and the injection cutting magnet on the injection linear section, and is used to give the beam a lateral kick angle so that the beam enters the periodic closed loop acceptance; a plurality of injection cam magnets, which are arranged on the injection linear section, the post-injection linear section and the pre-injection linear section, and are used to form a local cam at the injection electrostatic cutter and to complete the beam injection by controlling the strength of a plurality of injection cam magnets.

[0056] According to an embodiment of the present invention, the number of the plurality of injection bump magnets is four.

[0057] like Figure 5As shown, in an embodiment of the present invention, a multi-circle injection system is used, including an injection cutting magnet 7, an injection electrostatic cutter 8 and four injection cam magnets 13-1, 13-2, 13-3 and 13-4. The cam magnet forms a local cam in the synchronization ring, and the acceptance of the ring is close to the injection electrostatic cutter. The beam accelerated by the linear accelerator is injected into the synchrotron through the injection cutting iron, and then the injection electrostatic deflection plate gives the beam a lateral kick angle to enter the acceptance of the synchronization ring; with the continuous injection of the beam, the strength of the cam magnet gradually decreases, so that the beam fills the horizontal acceptance of the entire cycle closed loop, thereby completing the beam injection. Among them, the rectangular blocks located above and below the horizontal coordinate are symmetrical are dipole magnets, the blocks located above the horizontal coordinate are horizontal focusing quadrupole magnets, and the blocks located below the horizontal coordinate are vertical focusing quadrupole magnets.

[0058] Figure 6 The diagram schematically shows a beam extraction trajectory diagram according to an embodiment of the present invention.

[0059] According to an embodiment of the present invention, the synchrotron accelerator further includes: an extraction electrostatic cutter 10, which is arranged between the horizontal position probe and the bidirectional position probe on the extraction front straight section, and is used to provide a lateral kick angle for the preset energy beam, so that the preset energy beam is cut and separated; a plurality of extraction cutting magnets, which are arranged at one end of the horizontal focusing quadrupole magnet on the extraction straight section away from the sextupole magnet, and are used to extract the preset energy beam that has been cut and separated.

[0060] According to an embodiment of the present invention, the number of the plurality of lead-out cutting magnets is two, namely 9 - 1 and 9 - 2 .

[0061] like Figure 6 As shown, in an embodiment of the present invention, by designing the positions of the lead-out electrostatic cutter and the lead-out cutting magnet, the working point is close to 1.666 in a periodic closed loop with a period of 6, the phase shift of each period is about 100 degrees, and the phase shift between the lead-out electrostatic cutter and the lead-out cutting magnet is 90 degrees. It can be achieved that the beam has a larger offset at the lead-out cutting magnet, and the installation position is close to the horizontal focusing quadrupole magnet. At this time, the horizontal envelope function β has a maximum value, which is beneficial to the design of the lead-out track and reduces the strength of the electrostatic cutter.

[0062] According to an embodiment of the present invention, it also includes: an extraction lateral excitation 12, which is arranged on any one of the straight segments and is used to excite the lateral vibration of the preset energy beam, so that the preset energy beam enters the unstable area to be extracted; a plurality of extraction cam magnets, which are arranged on the straight segment after injection, the straight segment before extraction and the extraction straight segment, and are used to form a local cam at the extraction electrostatic cutter to make the preset energy beam close to the pole plate of the extraction electrostatic cutter to reduce beam loss.

[0063] According to an embodiment of the present invention, the number of the plurality of lead-out cam magnets is 3, namely 14 - 1 , 14 - 2 and 14 - 3 .

[0064] Figure 7 A schematic diagram of an ion beam therapy device according to an embodiment of the present invention is schematically shown.

[0065] like Figure 7 As shown, according to an embodiment of the present invention, the ion beam cancer treatment device further includes: an ion source 17 for providing low-energy ions; the ion source includes a proton source, a helium ion source and a carbon ion source.

[0066] According to an embodiment of the present invention, the ion source is an electron cyclotron resonance ion source or a laser ion source.

[0067] In an embodiment of the present invention, the ion source can be configured according to demand. When the number of ion sources is 2, it can be configured as a proton source and a helium ion source or a proton source and a carbon ion source. When the number of ion sources is 3, it can be configured as a proton source, a helium ion source and a carbon ion source.

[0068] The ion beam cancer treatment device provided by the present invention can accelerate multiple ions, mainly providing protons and helium ions, and taking into account carbon ions of a certain energy. The energy of the proton beam can reach 230MeV, the energy of the helium ion beam can reach 230MeV / u, and the water equivalent range is about 33cm, which meets the needs of clinical radiotherapy. The energy of the carbon ion beam can reach 230MeV / u, and the water equivalent range is about 10cm, which can cover the radiotherapy of head and neck tumors and shallow tumors in other parts.

[0069] According to an embodiment of the present invention, the ion beam therapy device also includes: a Glasser lens 18, which is used to initially focus the low-energy ions; an analysis magnet 19, which is used to screen the focused low-energy ions to obtain preset ions; and two solenoid coils 20, which are used to perform secondary focusing on the preset ions to meet the linear accelerator's requirements for the initial transverse phase space of the beam.

[0070] According to an embodiment of the present invention, the ion beam therapy device further comprises: a linear accelerator for accelerating low-energy ions to obtain a medium-energy beam.

[0071] According to an embodiment of the present invention, the linear accelerator includes: a radio frequency quadrupole accelerator (RFQ) 21, which is used to accelerate the preset ions after secondary focusing to an energy level of 0.6 MeV / u; a drift tube linear accelerator (DTL) 22, which is used to accelerate the beam accelerated by the radio frequency quadrupole accelerator to an energy level of 4-7 MeV / u again; and the linear accelerator can be configured as RFQ21+DTL22 or RFQ21+DTL22+DTL22 according to different requirements of the beam energy level.

[0072] According to an embodiment of the present invention, the linear accelerator further comprises: 3 quadrupole magnets, arranged between RFQ+DTL or between DTL+DTL, for focusing the accelerated beam to meet the requirements of the transverse phase space of the adjacent linear accelerator below.

[0073] According to an embodiment of the present invention, a stripping film 23 is further provided below the linear accelerator for converting ions accelerated by the linear accelerator into ions actually required for treatment.

[0074] In the embodiment of the present invention, common ions used for treatment such as protons H + 、Helium ions 4 He 2+ Carbon ions 12 C 6+ The charge-to-mass ratio is too different to be accelerated by the same linear accelerator, so the ion source usually produces H3 + , 4 He 2+ , 12 C 4+ Ions with similar charge-to-mass ratios are accelerated and converted into H + and 12 C 6+ ,in 4 He 2+ It is already in a completely peeled state, and the film valence will not change after peeling.

[0075] According to an embodiment of the present invention, the ion beam therapy device also includes a medium-energy beam line, which is arranged between the linear accelerator and the synchrotron accelerator, and is used to transmit the accelerated beam to the synchrotron accelerator; wherein the medium-energy beam line includes a plurality of dipole magnets and a plurality of quadrupole magnets, which can be adjusted and designed according to actual needs.

[0076] According to an embodiment of the present invention, the ion beam therapy device further includes: a high-energy beam transport line, which is composed of a plurality of dipole magnets and a plurality of quadrupole magnets and is used to transmit particles accelerated by a synchrotron to each treatment room, and the shape of which can be adjusted according to the actual layout and needs of the treatment room.

[0077] It will be appreciated by those skilled in the art that the features described in the various embodiments and / or claims of the present invention may be combined and / or coupled in various ways, even if such combinations and / or couplings are not explicitly described in the present invention. In particular, the features described in the various embodiments and / or claims of the present invention may be combined and / or coupled in various ways without departing from the spirit and teachings of the present invention. All of these combinations and / or couplings fall within the scope of the present invention.

[0078] The embodiments of the present invention are described above. However, these embodiments are only for the purpose of illustration, and are not intended to limit the scope of the present invention. Although each embodiment is described above, it does not mean that the measures in each embodiment cannot be used in combination. The scope of the present invention is defined by the attached claims and their equivalents. Without departing from the scope of the present invention, those skilled in the art may make various substitutions and modifications, which should all fall within the scope of the present invention.

Claims

1. An ion beam therapy device, characterized in that: Includes a synchrotron to accelerate the beam to a preset energy beam: The synchrotron includes six unit structures, each of which includes a dipole magnet, a horizontal focusing quadrupole magnet, a vertical focusing quadrupole magnet and a linear segment; wherein the horizontal focusing quadrupole magnet and the vertical focusing quadrupole magnet are arranged on the linear segment, and one end of the linear segment is connected to the dipole magnet; The free end of the linear segment in a single unit structure is connected to the two-pole magnet in an adjacent unit structure, so that the six unit structures form a periodic closed loop.

2. The ion beam therapy device according to claim 1, characterized in that: In the periodic closed loop, along the direction of beam transmission starting from the beam injection point, the straight line segments are, in sequence, an injection straight line segment, a post-injection straight line segment, a pre-lead-out straight line segment, a lead-out straight line segment, a post-lead-out straight line segment, and a pre-injection straight line segment; wherein the injection straight line segment and the lead-out straight line segment are symmetrical straight line segments.

3. The ion beam therapy device according to claim 2, characterized in that: The synchrotron further comprises: Six sextupole magnets, each of the sextupole magnets is disposed between the horizontal focusing quadrupole magnet and the dipolar magnet; A correction magnet is arranged on one end of the vertical focusing quadrupole magnet on each of the linear segments away from the dipole magnet and one end of the horizontal focusing quadrupole magnet on the post-injection linear segment, the post-extraction linear segment and the pre-injection linear segment away from the sextupole magnet, for correcting the trajectory of the beam; A position probe is arranged on one end of the vertical focusing quadrupole magnet on each of the linear segments away from the dipole magnet and on one end of the horizontal focusing quadrupole magnet on the injection linear segment, the post-injection linear segment, the lead-out front linear segment, the lead-out post-linear segment and the pre-injection linear segment away from the sextupole magnet, for detecting the trajectory of the beam.

4. The ion beam therapy device according to claim 3, characterized in that: The correction magnets arranged on the injection straight segment, the post-injection straight segment, the lead-out front straight segment and the end of the vertical focusing quadrupole magnet on the lead-out straight segment away from the dipole magnet are all bidirectional correction magnets; The correction magnets arranged on the ends of the vertical focusing quadrupole magnets on the lead-out rear straight section and the injection front straight section away from the dipole magnets are both vertical correction magnets; The position probes under the bidirectional correction magnets on the injected linear segment and the injected linear segment are both vertical position probes; The position probes under the bidirectional correction magnets on the lead-out front straight section and the lead-out straight section are both bidirectional position probes; The position probes under the vertical correction magnets on the post-extraction linear segment and the pre-injection linear segment are both vertical position probes.

5. The ion beam therapy device according to claim 3, characterized in that: The position probes arranged on the ends of the horizontal focusing quadrupole magnet away from the sextupole magnet on the injection straight segment, the post-injection straight segment, the pre-lead straight segment, the post-lead straight segment and the pre-injection straight segment are all horizontal position probes; The correction magnets arranged at the ends of the horizontal focusing quadrupole magnets on the post-injection straight segment, the lead-out post-injection straight segment and the pre-injection straight segment away from the sextupole magnet are all horizontal correction magnets.

6. The ion beam therapy device according to claim 4, characterized in that: The synchrotron further comprises: The high-frequency accelerating cavity is arranged on the lead-out rear straight section and is used for accelerating or decelerating the beam.

7. The ion beam therapy device according to claim 6, characterized in that: The synchrotron further comprises: An injection cutting magnet, disposed between the horizontal position probe and the vertical position probe on the injection linear section, for introducing a beam into the synchrotron; An injection electrostatic cutter, disposed between the vertical position probe on the injection linear section and the injection cutting magnet, is used to give the beam a lateral kick angle so that the beam enters the periodic closed loop acceptance; A plurality of injection cam magnets are arranged on the injection linear section, the post-injection linear section and the pre-injection linear section, and are used to form a local cam at the injection electrostatic cutter and complete the beam injection by controlling the strength of the plurality of injection cam magnets.

8. The ion beam therapy device according to claim 7, characterized in that: The synchrotron further comprises: An extraction electrostatic cutter is arranged between the horizontal position probe and the bidirectional position probe on the extraction front straight section, and is used to provide a lateral kick angle for reaching the preset energy beam, so that the preset energy beam is cut and separated; A plurality of lead-out cutting magnets are arranged on the lead-out linear segment at one end of the horizontal focusing quadrupole magnet away from the sextupole magnet, and are used to lead out the preset energy beam after cutting and separation.

9. The ion beam therapy device according to claim 8, characterized in that: Also includes: Extraction lateral excitation, arranged on any one of the linear segments, for exciting the lateral vibration of the preset energy beam, so that the preset energy beam enters the unstable region to be extracted; A plurality of lead-out convex track magnets are arranged on the post-injection straight section, the pre-lead-out straight section and the lead-out straight section, and are used to form a local convex track at the lead-out electrostatic cutter to make the preset energy beam close to the pole plate of the lead-out electrostatic cutter.

10. The ion beam therapy device according to claim 1, characterized in that: The ion beam cancer treatment device also includes: an ion source for providing low-energy ions; The ion source includes a proton source, a helium ion source and a carbon ion source.

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