Wearable biomechanical artificial kidney peritoneal dialysis device

Abstract

The invention provides a wearable biomechanical artificial kidney peritoneal dialysis device, and relates to the technical field of peritoneal dialysis. The peritoneal dialysis fluid circulating unit comprises a three-way pipe, a fluid inlet pipe, a fluid outlet pipe, a pre-filtration peritoneal dialysis fluid storage device, a post-filtration peritoneal dialysis fluid storage device and a peritoneal dialysis fluid filter, and two ports of the peritoneal dialysis fluid filter are connected with the pre-filtration peritoneal dialysis fluid storage device and the post-filtration peritoneal dialysis fluid storage device through a first connecting pipe and a second connecting pipe respectively; the in-vitro active kidney circulation unit comprises an active homologous or heterologous in-vitro kidney, a first hose and a second hose, and further comprises a ureter and a urine receiving container. Peritoneal dialysis liquid and exchange liquid in in-vitro kidney circulation can be recycled, a patient does not need to carry a large amount of peritoneal dialysis liquid, the device is convenient to carry, the burden of the peritoneal dialysis patient is effectively relieved, and convenience is brought to the patient; the in-vitro active kidney can remove more toxins in the dialysate; the device is high in practicability, remarkable in effect and worthy of popularization.

Description

Technical Field

[0001] The present invention relates to the technical field of peritoneal dialysis, and in particular to a wearable biomechanical artificial kidney peritoneal dialysis device. Background Art

[0002] Peritoneal dialysis is a dialysis treatment method used to replace kidney function. The treatment injects sterile, heat-free dialysate into the patient's peritoneal cavity. The peritoneum acts as a natural semipermeable membrane, and uremic toxins and various ions diffuse from the patient's bloodstream through the peritoneum into the peritoneal dialysis fluid via an osmotic gradient. The existing peritoneal dialysis process requires a large amount of peritoneal dialysis fluid. According to the conventional peritoneal dialysis, 4 replacements per day, 2L each time, the daily peritoneal dialysis fluid usage is 8L, which brings a serious burden to peritoneal dialysis patients and seriously affects the quality of life, learning and work convenience of patients.

[0003] The wearable peritoneal dialysis equipment with patented designs removes known toxins such as urea from the replaced peritoneal dialysis fluid through enzymes, adsorption, filtration membranes and other modes, but has the following shortcomings: 1. It can only remove some of the currently identified uremic toxins in the peritoneal dialysis fluid, does not have the toxin removal capabilities of biological kidneys, and does not achieve the most effective kidney replacement; 2. The adsorbent has very limited ability and types of toxin removal in the peritoneal dialysis fluid, and the adsorber needs to be replaced regularly and frequently; 3. In addition, the existing portable peritoneal dialysis method will produce a certain amount of waste fluid, and a large amount of peritoneal dialysis fluid still needs to be supplemented during the treatment process to maintain the treatment effect; 4. The existing biological artificial kidneys such as implanted renal tubular epithelial cells are unable to enter clinical application due to technical difficulties such as cell survival, biocompatibility, energy and oxygen supply limitations that have not been overcome.

[0004] Therefore, the patent application of the present invention intends to achieve the purpose of wearable, continuous peritoneal dialysis by integrating a common semipermeable membrane filter, a mechanical circulation device, and a biologically active isolated kidney, thereby solving the current problem. Summary of the invention

[0005] The purpose of the present invention is to provide a wearable biomechanical artificial kidney peritoneal dialysis device that achieves the purpose of wearable and continuous peritoneal dialysis by integrating a common semipermeable membrane filter, a mechanical circulation device, and a biologically active isolated kidney.

[0006] In order to achieve the above-mentioned purpose, the technical solution adopted by the present invention is: a wearable biomechanical artificial kidney peritoneal dialysis device, comprising:

[0007] A peritoneal dialysis tube is placed in the patient's abdomen;

[0008] A peritoneal dialysis fluid circulation unit, comprising a three-way pipe connected to a peritoneal dialysis tube, a liquid inlet pipe and a liquid outlet pipe respectively connected to the other two ports of the three-way pipe, a peritoneal dialysis fluid storage device after filtration and a peritoneal dialysis fluid storage device before filtration respectively connected to the other ends of the liquid inlet pipe and the liquid outlet pipe, and a peritoneal dialysis fluid filter connected between the peritoneal dialysis fluid storage device after filtration and the peritoneal dialysis fluid storage device before filtration, wherein two ports on the side wall of the peritoneal dialysis fluid filter are respectively connected to the peritoneal dialysis fluid storage device before filtration and the peritoneal dialysis fluid storage device after filtration through a first connecting pipe and a second connecting pipe, and the peritoneal dialysis fluid filter is also provided with a blood input port and a blood output port;

[0009] An isolated active kidney circulation unit, wherein both ends of the artery and vein of the isolated active kidney are respectively connected to the blood input port and the blood output port to form an isolated active kidney blood circulation filtration passage;

[0010] Among them, the liquid inlet pipe and the liquid outlet pipe are respectively provided with a pump one, the first connecting pipe and the second connecting pipe are respectively provided with a pump three, and the liquid inlet pipe and the liquid outlet pipe are also respectively provided with a valve.

[0011] The purpose of the present invention and the solution to its technical problems can be further achieved by adopting the following technical measures.

[0012] Furthermore, the isolated active kidney circulation unit comprises an active isolated active kidney, a first hose connected between a venous port of the isolated active kidney and the blood input port, and a second hose connected between an arterial port of the isolated active kidney and the blood output port, and the isolated active kidney further comprises a ureter and a urine receiving container connected to the other end of the ureter;

[0013] The first hose and the second hose are respectively provided with a pump 2.

[0014] Furthermore, a monitoring unit is provided on the second connecting tube, and the monitoring unit includes a monitoring sensor module, a processing module, a display module and an alarm module. The monitoring unit is used for real-time monitoring of ions and biochemical parameters in the peritoneal dialysis fluid.

[0015] Furthermore, the second hose is also provided with an extracorporeal membrane oxygenation device.

[0016] Furthermore, one end of the three-way tube is detachably connected to the outer port of the peritoneal dialysis tube.

[0017] Furthermore, the urine receiving container is a urine storage bag, and the urine storage bag is detachably connected to the ureter.

[0018] Furthermore, the ureter is connected to the patient's bladder fistula tube to drain urine into the bladder for storage.

[0019] Furthermore, it also includes a storage structure with a cavity, and the storage structure is used to load the peritoneal dialysis fluid circulation unit and the isolated active kidney circulation unit.

[0020] Furthermore, the storage structure is a box body or a bag body, and a fixing belt connected to a human body is provided on the outer side of the box body or the bag body.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] 1. The wearable biomechanical artificial kidney peritoneal dialysis device of the present invention is provided with a peritoneal dialysis fluid circulation unit composed of a three-way pipe, a liquid inlet pipe, a liquid outlet pipe, a peritoneal dialysis fluid storage device after filtration, a peritoneal dialysis fluid storage device before filtration, a first connecting pipe, a second connecting pipe and a peritoneal dialysis fluid filter, and a pump is respectively provided on each pipeline, so that the peritoneal dialysis fluid can form a loop in the entire peritoneal dialysis fluid circulation unit, and the peritoneal dialysis fluid containing uremic toxins can be circulated and filtered by the in vitro biologically active kidney, so that the peritoneal dialysis fluid can be recycled, and the patient does not need to carry a large amount of peritoneal dialysis fluid, which effectively reduces the burden of peritoneal dialysis patients and brings convenience to the patients' life, study and work.

[0023] 2. The wearable biomechanical artificial kidney peritoneal dialysis device of the present invention is provided with an isolated active kidney circulation unit, and its two ends are respectively connected to the blood input port and the blood output port to form a blood circulation filtration loop. The blood can take away the toxins in the waste peritoneal dialysis fluid through the peritoneal dialysis fluid filter, and the blood with toxins can remove the toxins through the isolated active kidney circulation unit, and then be returned to the peritoneal dialysis fluid filter for circulation and use; the use of isolated active kidneys in this device to remove toxins has the following advantages over the existing method of removing the replaced peritoneal dialysis fluid through enzymes, adsorption, filtration membranes and other modes: 1. The biological active kidney has the toxin removal ability of the biological kidney, which can effectively remove more toxins in the blood, so that the patient can achieve the most effective dialysis; 2. The biological active kidney has a lasting toxin removal ability in the active state, and it can survive for a long time and be used for a longer time; 3. The peritoneal dialysis fluid and blood in this device can be recycled, and the biological kidney only produces a small amount of waste fluid, namely urine; 4. The in vitro survival technology of biological organs is mature, and the present device is highly practical and effective, and is worthy of promotion.

[0024] 3. The wearable biomechanical artificial kidney peritoneal dialysis device of the present invention can be stored by providing a storage structure, which is easy to carry; further, by providing a fixing belt, such as a shoulder strap, a waist belt, etc., on the box body or the bag body, the device can be worn on the patient, providing convenience for the patient's travel, work and study. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1The overall structure of the wearable biomechanical artificial kidney peritoneal dialysis device provided by the present invention is shown in FIG. Figure 1 ;

[0026] Figure 2 The overall structure of the wearable biomechanical artificial kidney peritoneal dialysis device provided by the present invention is shown in FIG. Figure 2 (Add monitoring unit);

[0027] Figure 3 The overall structure of the wearable biomechanical artificial kidney peritoneal dialysis device provided by the present invention is shown in FIG. Figure 2 (Addition of extracorporeal membrane oxygenation device);

[0028] Figure 4 It is a schematic diagram of the overall structure of the storage structure in the wearable biomechanical artificial kidney peritoneal dialysis device provided by the present invention;

[0029] Description of reference numerals:

[0030] 1. Peritoneal dialysis tube;

[0031] 2. peritoneal dialysis fluid circulation unit; 21. three-way pipe; 22. liquid inlet pipe; 23. liquid outlet pipe; 24. peritoneal dialysis fluid storage after filtration; 25. peritoneal dialysis fluid storage before filtration; 26. pump 1; 27. valve;

[0032] 3. peritoneal dialysis fluid filter; 31. first connecting tube; 32. second connecting tube; 33. blood inlet; 34. blood outlet; 35. pump three;

[0033] 4. Isolated active kidney circulation unit; 41. Isolated active kidney; 42. First hose; 43. Second hose; 44. Ureter; 45. Urine receiving container; 46. Pump 2;

[0034] 5. Monitoring unit;

[0035] 6. Extracorporeal membrane oxygenation device;

[0036] 7. Storage structure; 71. Fixing strap. DETAILED DESCRIPTION

[0037] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0038] See also Figure 1 , a wearable biomechanical artificial kidney peritoneal dialysis device, comprising:

[0039] A peritoneal dialysis tube inserted into the patient's abdominal cavity 1;

[0040] A peritoneal dialysis fluid circulation unit 2, comprising a three-way pipe 21 connected to the peritoneal dialysis tube 1, a liquid inlet pipe 22 and a liquid outlet pipe 23 respectively connected to the other two ports of the three-way pipe 21, a post-filtration peritoneal dialysis fluid reservoir 24 and a pre-filtration peritoneal dialysis fluid reservoir 25 respectively connected to the other ends of the liquid inlet pipe 22 and the liquid outlet pipe 23, and a peritoneal dialysis fluid filter 3 connected between the post-filtration peritoneal dialysis fluid reservoir 24 and the pre-filtration peritoneal dialysis fluid reservoir 25, wherein two ports on the side wall of the peritoneal dialysis fluid filter 3 are respectively connected to the pre-filtration peritoneal dialysis fluid reservoir 25 and the post-filtration peritoneal dialysis fluid reservoir 24 through a first connecting pipe 31 and a second connecting pipe 32, and a blood input port 33 and a blood output port 34 are also provided on the peritoneal dialysis fluid filter 3;

[0041] The isolated active kidney circulation unit 4 has arteriovenous ends of the isolated active kidney connected to the blood input port 33 and the blood output port 34 respectively to form an isolated active kidney blood circulation filtration passage. The liquid in the isolated active kidney circulation is preferably blood or component blood containing red blood cells, or it can be a liquid containing red blood cells, or other liquids with oxygen and carbon dioxide transport capabilities.

[0042] The liquid inlet pipe 22 and the liquid outlet pipe 23 are provided with a pump 1 26 , respectively. The first connecting pipe 31 and the second connecting pipe 32 are provided with a pump 3 35 , respectively. The liquid inlet pipe 22 and the liquid outlet pipe 23 are also provided with a valve 27 .

[0043] In the present invention, when peritoneal dialysis is needed, a certain amount of peritoneal dialysis fluid (including various types of peritoneal dialysis fluid) is stored in the peritoneal dialysis fluid storage 24, the valve 27 and pump 1 26 on the inlet tube 22 are opened, and the peritoneal dialysis fluid is infused from the peritoneal dialysis tube 1 into the patient's abdomen, and then the valve 27 and pump 1 26 on the inlet tube 22 are closed, and then a period of time is waited, and the toxins in the patient's body enter the peritoneal dialysis fluid through the filtration of the peritoneum; then the valve 27 and pump 1 26 on the outlet tube 23 are opened, and the peritoneal dialysis fluid with toxins is drained out and stored in the pre-filtration peritoneal dialysis fluid storage 25, and then the pump 3 35 on the first connecting tube 31 and the second connecting tube 32 is opened, and the isolated active kidney circulation unit 4 is turned on, so that the peritoneal dialysis fluid with toxins is exchanged and removed with the blood of the isolated active kidney circulation unit through the filter 3, and finally returned to the peritoneal dialysis fluid storage 24 for storage, so as to be used for the next peritoneal dialysis fluid exchange. Finally, a circulation exchange is formed to achieve the purpose of continuous peritoneal dialysis. A large amount of peritoneal dialysis fluid is required during the existing peritoneal dialysis process. According to the conventional peritoneal dialysis, 2L is replaced four times a day, and the daily peritoneal dialysis fluid usage is 8L. The filter and the isolated active kidney circuit of the device allow the peritoneal dialysis fluid to be recycled. Patients do not need to carry a large amount of peritoneal dialysis fluid, which effectively reduces the burden on peritoneal dialysis patients and brings convenience to patients' lives, studies and work. Moreover, the method of removing toxins from the dialysate by the isolated active kidney has more advantages than the existing methods of removal through enzymes, adsorption, filtration membranes and other modes, making the device highly practical and effective, and worthy of promotion.

[0044] Preferably, the isolated active kidney circulation unit 4 includes an active isolated active kidney 41, a first hose 42 connected between the venous port of the isolated active kidney 41 and the blood input port 33, and a second hose 43 connected between the arterial port of the isolated active kidney 41 and the blood output port 34. The isolated active kidney 41 also includes a ureter 44 and a urine receiving container 45 connected to the other end of the ureter 44; an extracorporeal circulation is established for the isolated active kidney, and it has the function of transporting oxygen (combined / uncombined oxygen supply equipment: extracorporeal oxygen / carbon dioxide exchange module), nutrition, energy, exchanged toxins and excess water, and has the function of regulating the urine filtration and reabsorption efficiency of the isolated active kidney; and has the function of monitoring the biological activity state of the isolated active kidney. At present, the in vitro survival technology of the isolated active kidney 41 has been maturely applied, and xenogeneic organs can survive for a long time in vitro. The specific storage method can refer to the organ transplantation technology, which is not described in detail in the present invention. It should also be noted that the isolated active kidney circulation unit 4 of the present invention is not limited to the use of xenogeneic kidneys. Under mature technical conditions, homologous kidneys can also be used, as long as the purpose of filtering and circulating blood / liquid containing red blood cells / liquid with oxygen and carbon dioxide transport capabilities can be achieved.

[0045] A second pump 46 is provided on the first hose 42 and the second hose 43 respectively.

[0046] Reference Figure 2 As shown in the figure, a monitoring unit 5 is also provided on the second connecting tube 32, and the monitoring unit 5 includes a monitoring sensor module, a processing module, a display module and an alarm module. The monitoring unit 5 is used to monitor the ions and biochemical parameters in the peritoneal dialysis fluid in real time, such as detecting the acid-base, ion composition, osmotic pressure and other biochemical index parameters of the peritoneal dialysis fluid, and monitoring the working status of the semipermeable membrane and the peritoneal dialysis circulation unit. Specifically, the monitoring sensor module transmits the monitored biochemical index parameters such as acid-base, ion composition, osmotic pressure to the processing module, and the processing module processes the information and transmits it to the display module for display so that the patient can view it in real time, and the processing module can compare the monitored information with its own preset value. If an abnormality occurs, the alarm module is activated to sound an alarm or automatically adjust the operating parameters of the entire system, and the alarm content that requires human intervention is prompted to the patient / medical worker.

[0047] Reference Figure 3 As shown in, the second hose 43 is also provided with an extracorporeal membrane oxygenation device 6, i.e., an oxygen / carbon dioxide exchange unit, which can provide oxygen for the isolated active kidney circulation unit 4. In the present invention, the liquid in the isolated active kidney circulation is preferably blood or component blood containing red blood cells, because it has a good oxygen transport function. Therefore, the use of the extracorporeal membrane oxygenation device 6 can be selected / adjusted according to the parameters of the oxygen content in the blood; wherein, the extracorporeal membrane oxygenation device 6 can refer to the prior art and will not be described in detail here.

[0048] In order to separate or connect the device with the peritoneal dialysis tube 1 as needed, one end of the three-way tube 21 is detachably connected to the outer port of the peritoneal dialysis tube 1. The connection method can be selected from threaded connection, which is more compact and convenient.

[0049] Preferably, the urine receiving container 45 is a urine storage bag, and the urine storage bag is detachably connected to the ureter 44, so as to facilitate replacement of the urine storage bag.

[0050] As another embodiment of urine storage, the ureter 44 is connected to the patient's bladder fistula tube to drain urine into the bladder for storage.

[0051] In order to facilitate patients to carry the device for peritoneal dialysis, a storage structure 7 with a cavity is also included, and the storage structure 7 is used to load the peritoneal dialysis fluid circulation unit 2 and the isolated active kidney circulation unit 4. The cavity in the storage structure 7 is configured to be a cavity that can stably place the peritoneal dialysis fluid circulation unit 2 and the isolated active kidney circulation unit 4, which is convenient for transportation and carrying.

[0052] like Figure 4As shown in the figure, the storage structure 7 is a box body or a bag body, and the outer side of the box body or the bag body is provided with a fixing belt 71 connected to the human body. The fixing belt 71 can make the box body or the bag body worn or carried on the patient. The fixing belt 71 can be a shoulder strap, a waist belt or other fixing belts, so that the device can be worn on the patient, which provides convenience for the patient's travel, work and study.

[0053] The present invention is further described above in conjunction with the embodiments, but the present invention is not limited to the above-mentioned implementation modes, and various changes can be made within the knowledge scope of ordinary technicians in this field without departing from the purpose of the present invention.

Claims

1. A wearable biomechanical artificial kidney peritoneal dialysis device, comprising a peritoneal dialysis tube (1) inserted into the peritoneal cavity of a patient, characterized in that: Also includes: A peritoneal dialysis fluid circulation unit (2), comprising a three-way pipe (21) connected to a peritoneal dialysis tube (1), a liquid inlet pipe (22) and a liquid outlet pipe (23) respectively connected to the other two ports of the three-way pipe (21), a post-filtration peritoneal dialysis fluid storage unit (24) and a pre-filtration peritoneal dialysis fluid storage unit (25) respectively connected to the other ends of the liquid inlet pipe (22) and the liquid outlet pipe (23), and a peritoneal dialysis fluid filter (3) connected between the post-filtration peritoneal dialysis fluid storage unit (24) and the pre-filtration peritoneal dialysis fluid storage unit (25), wherein two ports on the side wall of the peritoneal dialysis fluid filter (3) are respectively connected to the pre-filtration peritoneal dialysis fluid storage unit (25) and the post-filtration peritoneal dialysis fluid storage unit (24) through a first connecting pipe (31) and a second connecting pipe (32), and the peritoneal dialysis fluid filter (3) is also provided with a blood input port (33) and a blood output port (34); An isolated active kidney circulation unit (4), wherein both ends of the artery and vein of the isolated active kidney are respectively connected to the blood input port (33) and the blood output port (34) to form an isolated active kidney blood circulation filtration passage; The liquid inlet pipe (22) and the liquid outlet pipe (23) are respectively provided with a pump one (26), the first connecting pipe (31) and the second connecting pipe (32) are respectively provided with a pump three (35), and the liquid inlet pipe (22) and the liquid outlet pipe (23) are also respectively provided with a valve (27).

2. The wearable biomechanical artificial kidney peritoneal dialysis device according to claim 1, characterized in that: The isolated active kidney circulation unit (4) comprises an active isolated active kidney (41), a first hose (42) connected between the venous port of the isolated active kidney (41) and the blood input port (33), and a second hose (43) connected between the arterial port of the isolated active kidney (41) and the blood output port (34). The isolated active kidney (41) further comprises a ureter (44) and a urine receiving container (45) connected to the other end of the ureter (44). A second pump (46) is provided on the first hose (42) and the second hose (43), respectively.

3. The wearable biomechanical artificial kidney peritoneal dialysis device according to claim 2, characterized in that: The second connecting tube (32) is also provided with a monitoring unit (5), which comprises a monitoring sensor module, a processing module, a display module and an alarm module. The monitoring unit (5) is used to monitor the ions and biochemical parameters in the peritoneal dialysis fluid in real time.

4. The wearable biomechanical artificial kidney peritoneal dialysis device according to claim 2, characterized in that: The second hose (43) is also provided with an extracorporeal membrane oxygenation device (6).

5. The wearable biomechanical artificial kidney peritoneal dialysis device according to claim 2, characterized in that: One end of the three-way tube (21) is detachably connected to the outer port of the peritoneal dialysis tube (1).

6. The wearable biomechanical artificial kidney peritoneal dialysis device according to claim 2, characterized in that: The urine receiving container (45) is a urine storage bag, and the urine storage bag is detachably connected to the ureter (44).

7. The wearable biomechanical artificial kidney peritoneal dialysis device according to claim 2, characterized in that: The ureter (44) is connected to the patient's cystostomy tube to drain urine into the bladder for storage.

8. The wearable biomechanical artificial kidney peritoneal dialysis device according to any one of claims 1 to 7, characterized in that: It also comprises a storage structure (7) having a cavity, wherein the storage structure (7) is used to load the peritoneal dialysis fluid circulation unit (2) and the isolated active kidney circulation unit (4).

9. The wearable biomechanical artificial kidney peritoneal dialysis device according to claim 7, characterized in that: The storage structure (7) is a box body or a bag body, and a fixing belt (71) connected to the human body is provided on the outer side of the box body or the bag body.

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