A selection valve

Abstract

The application relates to a selection valve, comprising: a stator and a rotor capable of relative rotation around a rotation axis, the stator and the rotor respectively having a first surface and a second surface opposite to each other and dynamically sealed; the first surface is provided with a first inlet and outlet hole, a second inlet and outlet hole, a first stator radial groove, a second stator radial groove and a plurality of pairs of component connecting holes, the component connecting holes comprising a first component connecting hole and a second component connecting hole; the second surface is provided with a rotor internal flow channel inlet, a rotor internal flow channel outlet, a rotor annular groove and a first rotor radial groove; when the rotor rotates relative to the stator, the first stator radial groove and the second stator radial groove can respectively communicate with the rotor internal flow channel outlet and the first rotor radial groove. According to the above scheme, the problems of complex structure and complex operation of the existing chromatography system can be improved, and the flushing of all flow channels in the selection valve can be realized, so that the accuracy of subsequent analysis is not affected due to internal residues of the selection valve.

Description

Technical Field

[0001] The present invention relates to the fields of protein purification, nucleic acid synthesis, liquid chromatography, and the like, and in particular to a selection valve for components such as a synthesis column or a chromatography column. Background Art

[0002] In fields such as protein purification, nucleic acid synthesis, and liquid chromatography, columns (such as synthesis columns or chromatography columns) are essential components for purifying, synthesizing, or differentiating analytes. During experiments, a selector valve (column position valve) is switched to allow the fluid to flow through the column in the forward direction, reverse direction, or without passing through the column, achieving the goal of purifying, synthesizing, or differentiating the analyte.

[0003] To meet more complex process requirements, chromatography systems can include multiple columns. Furthermore, multiple selector valves can be used to coordinate flow paths, enabling the combined operation of multiple columns. This allows liquid to flow through each column in a set sequence, or for each column to independently purify, synthesize, or differentiate different substances. Therefore, the large number of selector valves in complex chromatography systems not only complicates the system structure but also increases operational complexity. Summary of the Invention

[0004] The embodiments of the present application provide at least one selection valve, which can improve the problems of complex structure and operation of existing chromatography systems, and can flush all flow channels inside the selection valve to prevent the selection valve from affecting the accuracy of subsequent analysis due to internal residues.

[0005] An embodiment of the present application provides a selector valve, comprising: a stator and a rotor capable of relative rotation about a rotation axis, the stator and the rotor respectively having a first surface and a second surface facing each other and in dynamic sealing relationship;

[0006] The first surface is provided with a first access hole, a second access hole, a first stator radial slot, a second stator radial slot and a plurality of pairs of component connection holes, the first stator radial slot is connected to the second access hole, the first access hole is located at the rotation axis, the second stator radial slot and the first stator radial slot are symmetrically arranged with respect to the first access hole, each pair of component connection holes includes a first component connection hole and a second component connection hole, and the first component connection hole and the second component connection hole are symmetrically arranged with respect to the first access hole;

[0007] The second surface is provided with a rotor internal flow channel inlet, a rotor internal flow channel outlet, a rotor annular groove and a first rotor radial groove, the rotor internal flow channel inlet is located at the rotation axis to communicate with the first inlet and outlet hole, the rotor internal flow channel outlet and the rotor internal flow channel inlet are communicated with each other through a rotor internal flow channel provided in the rotor, the rotor annular groove is provided around the rotor internal flow channel inlet, the rotor annular groove is communicated with the first stator radial groove and the second stator radial groove, the first rotor radial groove is communicated with the rotor annular groove, and a line connecting the rotor internal flow channel inlet and the rotor internal flow channel outlet and the first stator radial groove is on the same straight line;

[0008] When the rotor rotates relative to the stator, one of the first component connecting hole and the second component connecting hole of the pair of component connecting holes is connected to the first rotor radial slot, and the other is connected to the outlet of the rotor internal flow channel, or one of the first stator radial slot and the second stator radial slot is connected to the first rotor radial slot, and the other is connected to the outlet of the rotor internal flow channel.

[0009] In an optional embodiment, the first stator radial slot and the second stator radial slot both extend from a second radius from the rotation axis to a first radius from the rotation axis, and

[0010] The first component connection hole and the second component connection hole are both located at a first radius from the rotation axis.

[0011] In an optional embodiment, the rotor internal flow channel outlet is located at the first radius from the rotation axis, the rotor annular groove has the rotation axis as the center and the radius as the second radius, and the first rotor radial groove extends from the second radius from the rotation axis to the first radius from the rotation axis.

[0012] In an optional embodiment, each first component connection hole of the multiple pairs of component connection holes is located on one side of a line connecting the first stator radial slot, the second stator radial slot and the first inlet and outlet hole, and each second component connection hole of the multiple pairs of component connection holes is located on the other side of a line connecting the first stator radial slot, the second stator radial slot and the first inlet and outlet hole.

[0013] In an optional embodiment, the first radius is greater than the second radius.

[0014] In an optional embodiment, the rotor is a double-layer structure including a first rotor part and a second rotor part, the first rotor part and the second rotor part respectively having a third surface and a fourth surface, the third surface and the fourth surface are opposite to each other and sealedly connected, one of the third surface and the fourth surface is provided with a second rotor radial groove, and the second rotor radial groove forms the rotor internal flow channel when the third surface and the fourth surface are sealedly connected.

[0015] In an optional embodiment, the rotor is a single-layer structure, and the rotor internal flow channel is formed by driving two intersecting flow channels into the interior of the rotor from the rotor internal flow channel inlet and the rotor internal flow channel outlet on the second surface.

[0016] In an optional embodiment, the second inlet and outlet hole is provided at any position within the length extension range of the first stator radial slot.

[0017] In an optional embodiment, the second inlet and outlet hole is arranged at the first radius away from the rotation axis.

[0018] In an optional embodiment, when the rotor rotates relative to the stator to a position where the first stator radial groove is connected to the first rotor radial groove and the second stator radial groove is connected to the rotor internal flow channel outlet, the liquid introduced into the rotary valve from the first inlet and outlet holes flows sequentially through the rotor internal flow channel inlet, the rotor internal flow channel, the rotor internal flow channel outlet, the second stator radial groove, the rotor annular groove, the first rotor radial groove, the first stator radial groove, and the second inlet and outlet holes, thereby achieving flushing of all flow channels inside the selection valve.

[0019] The above technical solution of this application has the following beneficial technical effects:

[0020] The selection valve of the embodiment of the present application can be connected to multiple columns through multiple component connection holes, that is, the first component connection hole and the second component connection hole of a component connection hole are respectively connected to the forward interface and the reverse interface of a column, and then by rotating the rotor relative to the stator to different positions, the liquid can pass through a column in the forward direction, pass through a column in the reverse direction, or not pass through the column. It can be seen that the selection valve can replace multiple column position valves and realize the function of a combination of multiple column position valves. Therefore, using the selection valve in the chromatography system is conducive to reducing the number of valves and simplifying the structure of the chromatography system. In addition, when the liquid does not pass through the column, the liquid can flow through all the flow channels inside the selection valve to achieve flushing of all the flow channels inside the selection valve, thereby avoiding the selection valve affecting the accuracy of subsequent analysis due to internal residues. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The drawings described herein are used to provide a further understanding of the present disclosure and constitute a part of the present disclosure. The exemplary embodiments of the present disclosure and their descriptions are used to explain the present disclosure and do not constitute an improper limitation of the present disclosure. In the drawings:

[0022] Figure 1 A schematic structural diagram of a selector valve provided in an embodiment of the present application;

[0023] Figure 2 is a schematic diagram of a first surface structure of a stator in some embodiments;

[0024] Figure 3 is a schematic diagram of the back structure of a stator in some embodiments;

[0025] Figure 4 Schematic diagram of various dimensions of the stator in some embodiments;

[0026] Figure 5 is a schematic diagram of the second surface structure of the first rotor part in some embodiments;

[0027] Figure 6 is a schematic diagram of the third surface structure of the first rotor part in some embodiments;

[0028] Figure 7 Schematic diagram of various dimensions of the first rotor part in some embodiments;

[0029] Figure 8 is a schematic diagram of the fourth surface structure of the second rotor portion in some embodiments;

[0030] Figure 9 is a schematic structural diagram of a rotor in some embodiments;

[0031] Figure 10 A schematic diagram of a selector valve provided in an embodiment of the present application in a first rotation position;

[0032] Figure 11 This is a schematic diagram of a chromatography system using the selection valve provided in an embodiment of the present application when the selection valve is in a first rotation position and liquid passes through column A in a forward direction;

[0033] Figure 12 A schematic diagram of a selector valve provided in an embodiment of the present application in a second rotation position;

[0034] Figure 13 This is a schematic diagram of a chromatography system using the selector valve provided in an embodiment of the present application when the selector valve is in a second rotation position and liquid passes through column A in the reverse direction;

[0035] Figure 14A schematic diagram of the selector valve provided in an embodiment of the present application in a third rotation position;

[0036] Figure 15 This is a schematic diagram of a chromatography system using the selection valve provided in an embodiment of the present application, when the selection valve is in a third rotation position and liquid does not pass through the column;

[0037] Reference numerals:

[0038] 100. Selection valve; 110. Stator; 111. First surface; 112. First inlet and outlet hole; 113. Second inlet and outlet hole; 114. First stator radial slot; 115. Second stator radial slot; 116. First component connecting hole; 117. Second component connecting hole; 120. Rotor; 121. First rotor part; 1211. Second surface; 1212. Rotor internal flow channel inlet; 1213. Rotor internal flow channel outlet; 1214. Rotor annular groove; 1215. First rotor radial slot; 1216. Third surface; 1217. Second rotor radial slot; 122. Second rotor part; 1221. Fourth surface. DETAILED DESCRIPTION

[0039] In order to enable those skilled in the art to better understand the technical solution of the present application, the present application is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0040] refer to Figures 1 to 15 The embodiment of the present application provides a selection valve 100, including: a stator 110 and a rotor 120 capable of relative rotation around a rotation axis L, the stator 110 and the rotor 120 respectively having a first surface 111 and a second surface 1211 that are opposite to each other and dynamically sealed.

[0041] A surface of the rotor 120 opposite to the first surface 111 of the stator 110 is a second surface 1211 of the rotor 120 .

[0042] The dynamic sealing connection between the second surface 1211 of the rotor 120 and the first surface 111 of the stator may be that the second surface 1211 of the rotor 120 and the first surface 111 of the stator abut against each other and there is a certain squeezing force between the two.

[0043] For example, the stator 110 and the rotor 120 can each be disc-shaped and of similar size. The rotation axis L of the rotor 120 when it is capable of rotating relative to the stator 110 can pass through the center (center of the circle) of the stator 110 and the rotor 120. Of course, the stator 110 and the rotor 120 can also have other shapes, such as square, prismatic, etc.

[0044] refer to Figure 2 and Figure 4The first surface 111 of the stator 110 is provided with a first access hole 112 and a second access hole 113. The first access hole 112 is located at the rotation axis L. The second access hole 113 is located at a first radius R1 away from the rotation axis L, as shown in Figure 4 .

[0045] The first access hole 112 can be an inlet, and the second access hole 113 can be an outlet; or the first access hole 112 can be an outlet, and the second access hole 113 can be an inlet. In the following description, the first access hole 112 is taken as an inlet (indicated by the letter IN in the drawings), and the second access hole 113 is taken as an outlet (indicated by the letter OUT in the drawings) as an example for description.

[0046] Referring to Figure 2 and Figure 4 , the first surface 111 of the stator 110 is provided with a first stator radial slot 114 and a second stator radial slot 115. The first stator radial slot 114 is in communication with the second access hole 113, and the second stator radial slot 115 is symmetrically arranged with the first stator radial slot 114 about the first access hole 112. Both the first stator radial slot 114 and the second stator radial slot 115 extend from a second radius R2 away from the rotation axis L to the first radius R1 away from the rotation axis L, and R1>R2, as shown in Figure 4 . Since the first access hole 112 is located at the rotation axis L, the second stator radial slot 115 is symmetrically arranged with the first stator radial slot 114 about the rotation axis L. In this context, symmetrically arranged means that the line connecting the second stator radial slot 115 and the first access hole 112 and the line connecting the first stator radial slot 114 and the first access hole 112 are on the same straight line, and the distance between the second stator radial slot 115 and the first access hole 112 is equal to the distance between the first stator radial slot 114 and the first access hole 112.

[0047] Referring to Figure 2 and Figure 4 , the first surface 111 of the stator 110 is provided with a plurality of pairs of component connection holes, each pair of component connection holes including a first component connection hole 116 and a second component connection hole 117. The first component connection hole 116 and the second component connection hole 117 are symmetrically arranged about the first access hole 112, and both the first component connection hole 116 and the second component connection hole 117 are located at the first radius R1 away from the rotation axis L. That is, the distance from the first component connection hole 116 / second component connection hole 117 to the rotation axis L (the first access hole 112) is equal to the distance from the second access hole 113 to the rotation axis L (the first access hole 112).

[0048] Referring to Figure 5 and Figure 7The second surface 1211 of the rotor 120 is provided with a rotor internal flow channel inlet 1212 and a rotor internal flow channel outlet 1213. The rotor internal flow channel inlet 1212 is located at the rotation axis L. That is, when the rotor 120 rotates relative to the stator 110, the rotor internal flow channel inlet 1212 can always be connected to the first inlet and outlet hole 112. The rotor internal flow channel outlet 1213 is located at a first radius R1 from the rotation axis L. That is, when the rotor 120 rotates relative to the stator 110, the rotor internal flow channel outlet 1213 can be connected to the first stator radial slot 114, the second stator radial slot 115, one of the first component connection holes 116, or one of the second component connection holes 117. Of course, when the rotor internal flow channel outlet 1213 is connected to the first stator radial slot 114, the rotor internal flow channel outlet 1213 can also be connected to the second inlet and outlet hole 113 through the first stator radial slot 114. Herein, rotor internal flow channel outlet 1213 and rotor internal flow channel inlet 1212 are openings of the rotor internal flow channel disposed in rotor 120 on second surface 1211 of rotor 120, and a line connecting rotor internal flow channel outlet 1213 and rotor internal flow channel inlet 1212 is collinear with first stator radial slot 114. Herein, the term rotor internal flow channel refers to a rotor flow channel structure located within the rotor and therefore not directly observable from the rotor's exterior.

[0049] refer to Figure 5 and Figure 7 The second surface 1211 of the rotor 120 is provided with a rotor annular groove 1214. Rotor annular groove 1214 is centered on the rotation axis L and has a radius of a second radius R2. In other words, rotor annular groove 1214 is provided around the rotor internal flow passage inlet 1212. When the rotor 120 rotates relative to the stator 110, rotor annular groove 1214 can always communicate with the first stator radial groove 114 and the second stator radial groove 115.

[0050] refer to Figure 5 and Figure 7 The second surface 1211 of the rotor 120 is provided with a first rotor radial slot 1215. The first rotor radial slot 1215 extends from a second radius R2 from the rotation axis L to a first radius R1 from the rotation axis L. In other words, the first rotor radial slot 1215 is connected to the rotor annular slot 1214. Furthermore, when the rotor 120 rotates relative to the stator 110, the first rotor radial slot 1215 can be connected to the first stator radial slot 114, the second stator radial slot 115, one of the first component connection holes 116, or one of the second component connection holes 117. Of course, when the first rotor radial slot 1215 is connected to the first stator radial slot 114, it can also be connected to the second inlet and outlet hole 113 through the first stator radial slot 114.

[0051] The selector valve 100 of the present embodiment can be connected to multiple posts via multiple pairs of component connection holes. Specifically, the first and second component connection holes 116 and 117 of a pair of component connection holes are connected to the forward and reverse ports of a post, respectively. When the rotor 120 rotates relative to the stator 110, one of the first and second component connection holes 116 and 117 can communicate with the first rotor radial slot 1215, while the other can communicate with the rotor internal flow channel outlet 1213. Alternatively, when the rotor 120 rotates relative to the stator 110, one of the first and second stator radial slots 114 and 115 can communicate with the first rotor radial slot 1215, while the other can communicate with the rotor internal flow channel outlet 1213. By rotating the rotor 120 relative to the stator 110 to different positions, the selector valve 100 can cause liquid to flow through a post in the forward direction, through a post in the reverse direction, or not flow through a post at all.

[0052] Exemplary, reference Figure 2 and Figure 3 The first surface 111 is provided with five pairs of component connection holes. The first component connection holes 116 of the five pairs of component connection holes are respectively defined as interface 1, interface 2, interface 3, interface 4, and interface 5. The second component connection holes 117 of the five pairs of component connection holes are respectively defined as interface A, interface B, interface C, interface D, and interface E. Among them, interface 1 and interface A are respectively used to connect to the forward interface and reverse interface of column A, interface 2 and interface B are respectively used to connect to the forward interface and reverse interface of column B, interface 3 and interface C are respectively used to connect to the forward interface and reverse interface of column C, interface 4 and interface D are respectively used to connect to the forward interface and reverse interface of column D, and interface 5 and interface E are respectively used to connect to the forward interface and reverse interface of column E.

[0053] refer to Figures 10 and 11 When the rotor 120 rotates to the first position, the rotor internal flow channel outlet 1213 communicates with port 1, and the first rotor radial slot 1215 communicates with port A, allowing liquid to flow forward through column A. The flow path is specifically as follows: first inlet and outlet hole 112 → rotor internal flow channel inlet 1212 → rotor internal flow channel → rotor internal flow channel outlet 1213 → port 1 → forward port of column A → column 1 → reverse port of column A → port A → first rotor radial slot 1215 → rotor annular slot 1214 → first stator radial slot 114 → second inlet and outlet hole 113.

[0054] refer to Figures 12 to 13When rotor 120 rotates to the second position, rotor internal flow channel outlet 1213 communicates with port A, and first rotor radial slot 1215 communicates with port 1, allowing liquid to flow in the reverse direction through column A. The specific flow direction is: first inlet and outlet hole 112 → rotor internal flow channel inlet 1212 → rotor internal flow channel → rotor internal flow channel outlet 1213 → port A → reverse port of column A → column A → forward port of column A → port 1 → first rotor radial slot 1215 → rotor annular slot 1214 → first stator radial slot 114 → second inlet and outlet hole 113.

[0055] refer to Figures 14 and 15 When rotor 120 rotates to the third position, rotor internal flow channel outlet 1213 connects to second stator radial slot 115, and first rotor radial slot 1215 connects to first stator radial slot 114 and second inlet / outlet hole 113, preventing liquid from passing through the column. The flow path is specifically: first inlet / outlet hole 112 → rotor internal flow channel inlet 1212 → rotor internal flow channel → rotor internal flow channel outlet 1213 → second stator radial slot 115 → rotor annular slot 1214 → first rotor radial slot 1215 → first stator radial slot 114 → second inlet / outlet hole 113.

[0056] Similarly, by rotating the rotor 120 relative to the stator 110 , the fluid can flow forward or backward through one of the pillars B, C, D, and E.

[0057] It can be seen that the selector valve 100 can replace multiple column valves and realize the function of a combination of multiple column valves. Therefore, using the selector valve 100 in a chromatography system is beneficial to reducing the number of valves and simplifying the system structure.

[0058] Furthermore, when the rotor 120 rotates to the third position, liquid can flow through all flow channels within the selector valve 100. Therefore, when the rotor 120 is in the third position, the liquid can be replaced with a cleaning fluid, which can flow through all flow channels within the selector valve 100 to flush all flow channels within the selector valve 100. This can prevent contamination caused by residual liquid within the selector valve 100 and affect the accuracy of subsequent analysis.

[0059] In some embodiments, reference Figure 2 and Figure 3 The first inlet and outlet hole 112, the second inlet and outlet hole 113, the first component connection hole 116 and the second component connection hole 117 are all holes that pass through the stator 110, that is, from Figure 2 The first surface 111 of the stator 110 shown extends through Figure 3 The stator 110 is shown with its back surface facing opposite to the first surface 111 .

[0060] In some embodiments, reference Figure 2 and Figure 5 Both the first surface 111 and the second surface 1211 are circular. When the first surface 111 and the second surface 1211 are sealed together, their centers coincide. Specifically, the first inlet and outlet hole 112 is located at the center of the first surface 111, and the rotor internal flow channel inlet 1212 is located at the center of the second surface 1211. When the second surface 1211 rotates circumferentially relative to the first surface 111, the first inlet and outlet hole 112 and the rotor internal flow channel inlet 1212 remain connected.

[0061] In some embodiments, reference Figure 2 and Figure 5 The first stator radial slots 114 and the second stator radial slots 115 are both arranged along the radial direction of the first surface 111 . The first rotor radial slots 1215 are arranged along the radial direction of the second surface 1211 .

[0062] In some embodiments, reference Figure 3 The first component connection holes 116 and the second component connection holes 117 are arranged at intervals along the circumference of the first access hole 112, and each pair of component connection holes includes the first component connection hole 116 and the second component connection hole 117, respectively, located on opposite sides of the first access hole 112. The angles between adjacent component connection holes can be equal or different. Figure 2 As shown, in this embodiment, each first component connection hole 116 of the multiple pairs of component connection holes is located on one side of a line connecting the first stator radial slot 114, the second stator radial slot 115, and the first inlet and outlet hole 112, while each second component connection hole 117 of the multiple pairs of component connection holes is located on the other side of a line connecting the first stator radial slot 114, the second stator radial slot 115, and the first inlet and outlet hole 112. This arrangement allows the component connection holes to be more centrally located, and a relatively small rotation of the rotor 120 relative to the stator 110 allows fluid to pass through different columns, facilitating operation of the selector valve 100.

[0063] In some embodiments, reference Figure 4 The distance between the first component connecting hole 116 / the second component connecting hole 117 and the first access hole 112 is equal to the distance between the second access hole 113 and the first access hole 112, and the second access hole 113 is located at a first radius R1 from the rotation axis L. With this arrangement, when the rotor 120 rotates to the third position, the distance between the end of the first rotor radial slot 1215 and the first access hole 112 is equal to the distance between the second access hole 113 and the first access hole 112, that is, the second access hole 113 is located at the end of the first rotor radial slot 1215, which facilitates thorough cleaning of the first rotor radial slot 1215.

[0064] It is conceivable that the second access hole 113 does not necessarily need to be located at the first radius R1 from the rotation axis L. The second access hole 113 can be located at any position within the length extension range of the first stator radial slot 114, and the first rotor radial slot 1215 can be effectively cleaned. In other words, the distance between the second access hole 113 and the rotation axis L is less than the first radius R1 and greater than the second radius R2.

[0065] In some embodiments, reference Figure 4 The first stator radial slot 114 and the second stator radial slot 115 are located between the first component connection hole 116 (interfaces 1 to 5) and the second component connection hole 117 (interfaces A to E). Figure 4 As shown, this embodiment shows that the first component connection hole 116 and the second component connection hole 117 of each pair of component connection holes are symmetrically arranged along the center line of the first surface 111, and the first stator radial slot 114 and the second stator radial slot 115 are arranged along the center line of the first surface 111.

[0066] In some embodiments, reference Figure 5 The rotor internal flow channel outlet 1213 and the first rotor radial groove 1215 are located outside the rotor annular groove 1214. In other embodiments, the rotor internal flow channel outlet 1213 and the first rotor radial groove 1215 may be located within the rotor annular groove 1214.

[0067] In some embodiments, reference Figure 1 、 Figure 6 and Figure 8 Rotor 120 has a two-layer structure, including a first rotor portion 121 and a second rotor portion 122. The first rotor portion 121 and the second rotor portion 122 have a third surface 1216 and a fourth surface 1221 facing each other, respectively. Third surface 1216 and fourth surface 1221 are sealed together, and when sealed together, they form a portion of the rotor's internal flow channel. This arrangement facilitates the provision of the rotor's internal flow channel in rotor 120 and reduces the requirements for production equipment. It should be understood that, in specific implementations, the rotor's internal flow channel inlet 1212 and the rotor's internal flow channel outlet 1213 may be holes extending through the thickness of the first rotor portion 121, forming a portion of the rotor's internal flow channel.

[0068] In some embodiments, reference Figure 6 and Figure 8 One of the third surface 1216 and the fourth surface 1221 is provided with a second rotor radial groove 1217, which forms a part of the rotor internal flow channel when the third surface 1216 and the fourth surface 1221 are sealed and connected. Figure 6 、 Figure 7 and Figure 8 As shown, this embodiment shows that a second rotor radial groove 1217 is provided on the third surface 1216. The second rotor radial groove 1217 extends from the rotation axis L to a first radius R1 from the rotation axis L. The fourth surface 1221 is a plane. When the third surface 1216 and the fourth surface 1221 are sealed together, the fourth surface 1221 can close the second rotor radial groove 1217 on the third surface 1216, thereby forming a portion of the rotor internal flow channel. It should be understood that in a specific implementation, the third surface 1216 and the fourth surface 1221 are both parallel to the second surface 1211, and the third surface 1216 and the second surface 1211 can respectively be two side surfaces in the thickness direction of the first rotor portion 121. That is, the third surface 1216 is the back surface of the first rotor portion 121, facing opposite to the second surface 1211.

[0069] In some embodiments, reference Figure 9 The rotor 120 has a single-layer structure, and its internal flow channel is formed by drilling or milling two intersecting flow channels into the rotor from the center of the second surface 1211 (rotation axis L, rotor internal flow channel inlet 1212) and a point at a first radius R1 from the rotation axis L (rotor internal flow channel outlet 1213). The two intersecting flow channels can have one extending longitudinally along the rotation axis and the other extending obliquely at an angle to the rotation axis, or both extending obliquely.

[0070] The above reference Figure 6 and Figure 8 The double-layer rotor described above may have leakage caused by poor sealing between the third surface 1216 and the fourth surface 1221. Although the single-layer rotor of this embodiment has higher manufacturing precision requirements for the two intersecting flow channels, it does not have the sealing problem of the double-layer structure.

[0071] The single-layer rotor can also be manufactured using 3D printing technology. This arrangement can facilitate the formation of a rotor internal flow channel in the rotor 120, which is conducive to reducing the difficulty of producing the rotor 120.

[0072] It should be understood that the rotor internal flow channel can be Figure 9 The V-shaped flow channel shown in the embodiment. Of course, the shape of the flow channel inside the rotor can also be other shapes, such as Figure 1 The U-shaped flow channel or the arc-shaped flow channel shown in the embodiment.

[0073] In addition to the above embodiments, those skilled in the art can also conceive of other forms of rotor internal flow channels, or other methods of processing rotor internal flow channels, as long as a rotor internal flow channel can be formed that bypasses the rotor annular groove 1214 on the second surface 1211 from the inside of the rotor and connects the rotor internal flow channel inlet 1212 and the rotor internal flow channel outlet 1213.

[0074] The selection valve 100 of the embodiment of the present application can be connected to multiple columns through multiple component connection holes, that is, the first component connection hole 116 and the second component connection hole 117 of a component connection hole are respectively connected to the forward interface and the reverse interface of a column, and then by rotating the rotor 120 to different positions relative to the stator 110, it can be achieved that the liquid passes through a column in the forward direction, passes through a column in the reverse direction, or does not pass through the column. It can be seen that the selection valve 100 can replace multiple column position valves and realize the function of a combination of multiple column position valves. Therefore, using the selection valve 100 in a chromatography system is conducive to reducing the number of valves and simplifying the structure of the chromatography system. In addition, when the liquid does not pass through the column, the liquid can flow through all the flow channels inside the selection valve 100 to achieve flushing of all the flow channels inside the selection valve 100, thereby preventing the selection valve 100 from affecting the accuracy of subsequent analysis due to internal residues.

[0075] The embodiment of the present application also provides a chromatography system, comprising: multiple columns and a selection valve 100. The forward interface and reverse interface of a column are respectively connected to the first component connection hole 116 and the second component connection hole 117 of a pair of component connection holes of the selection valve 100. The selection valve 100 can be connected to multiple columns through multiple component connection holes, that is, the first component connection hole 116 and the second component connection hole 117 of a component connection hole are respectively connected to the forward interface and the reverse interface of a column, and then by rotating the rotor 120 relative to the stator 110 to different positions, the liquid can pass through a column in the forward direction, pass through a column in the reverse direction, or not pass through the column. It can be seen that the selection valve 100 can replace multiple column position valves and realize the function of a combination of multiple column position valves. Therefore, using the selection valve 100 in the chromatography system is conducive to reducing the number of valves and simplifying the structure of the chromatography system. In addition, when the liquid does not pass through the column, the liquid can flow through all the flow channels inside the selection valve 100 to flush all the flow channels inside the selection valve 100, thereby preventing the selection valve 100 from affecting the accuracy of subsequent analysis due to internal residue.

[0076] The terms "first" and "second" in the specification and claims of this application may explicitly or implicitly refer to one or more of the features. Throughout the description of this application, unless otherwise specified, "plurality" means two or more. Furthermore, "and / or" in the specification and claims refers to at least one of the connected entities, and the character " / " generally indicates an "or" relationship between the connected entities.

[0077] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0078] In the description of this application, it should be noted that, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "connected" should be understood in a broad sense. For example, they can refer to fixed connections, detachable connections, or integral connections; mechanical connections or electrical connections; direct connections or indirect connections through an intermediate medium; and internal connections between two components. Those skilled in the art will understand the specific meanings of the above terms in this application based on the specific circumstances.

[0079] The one or more embodiments of this specification are intended to cover all such substitutions, modifications, and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of one or more embodiments of this specification shall be included within the scope of protection of this application.

[0080] The above are only specific embodiments of the present application, but the scope of protection of this application is not limited thereto. Any changes or substitutions that can be easily conceived by a person skilled in the art within the technical scope disclosed in this application should be included in the scope of protection of this application. Therefore, the scope of protection of this application should be based on the scope of protection of the claims.

Claims

1. A selector valve, characterized in that: include: A stator and a rotor capable of relative rotation about a rotation axis, the stator and the rotor respectively having a first surface and a second surface facing each other and in dynamic sealing relationship; The first surface is provided with a first access hole, a second access hole, a first stator radial slot, a second stator radial slot and a plurality of pairs of component connection holes, the first stator radial slot is connected to the second access hole, the first access hole is located at the rotation axis, the second stator radial slot and the first stator radial slot are symmetrically arranged with respect to the first access hole, each pair of component connection holes includes a first component connection hole and a second component connection hole, and the first component connection hole and the second component connection hole are symmetrically arranged with respect to the first access hole; The second surface is provided with a rotor internal flow channel inlet, a rotor internal flow channel outlet, a rotor annular groove and a first rotor radial groove, the rotor internal flow channel inlet is located at the rotation axis to communicate with the first inlet and outlet hole, the rotor internal flow channel outlet and the rotor internal flow channel inlet are communicated with each other through a rotor internal flow channel provided in the rotor, the rotor annular groove is provided around the rotor internal flow channel inlet, the rotor annular groove is communicated with the first stator radial groove and the second stator radial groove, the first rotor radial groove is communicated with the rotor annular groove, and a line connecting the rotor internal flow channel inlet and the rotor internal flow channel outlet and the first stator radial groove is on the same straight line; When the rotor rotates relative to the stator, one of the first component connecting hole and the second component connecting hole of the pair of component connecting holes is connected to the first rotor radial slot, and the other is connected to the outlet of the rotor internal flow channel, or one of the first stator radial slot and the second stator radial slot is connected to the first rotor radial slot, and the other is connected to the outlet of the rotor internal flow channel.

2. The selector valve according to claim 1, characterized in that: The first stator radial slot and the second stator radial slot each extend from a second radius from the rotation axis to a first radius from the rotation axis, and The first component connection hole and the second component connection hole are both located at a first radius from the rotation axis.

3. The selector valve according to claim 2, characterized in that: The outlet of the rotor internal flow channel is located at the first radius away from the rotation axis, the rotor annular groove has the rotation axis as the center and the radius is the second radius, and the first rotor radial groove extends from the second radius away from the rotation axis to the first radius away from the rotation axis.

4. The selector valve according to claim 1, wherein: Each first component connection hole of the multiple pairs of component connection holes is located on one side of a line connecting the first stator radial slot, the second stator radial slot and the first inlet and outlet hole, and each second component connection hole of the multiple pairs of component connection holes is located on the other side of a line connecting the first stator radial slot, the second stator radial slot and the first inlet and outlet hole.

5. The selector valve according to claim 3, characterized in that: The first radius is greater than the second radius.

6. The selector valve according to claim 1, characterized in that The rotor has a double-layer structure including a first rotor portion and a second rotor portion, wherein the first rotor portion and the second rotor portion respectively have a third surface and a fourth surface, wherein the third surface and the fourth surface are opposite to each other and are sealedly connected, and one of the third surface and the fourth surface is provided with a second rotor radial groove, and the second rotor radial groove forms the rotor internal flow channel when the third surface and the fourth surface are sealedly connected.

7. The selector valve according to claim 1, characterized in that The rotor has a single-layer structure, and the rotor internal flow channel is formed by driving two intersecting flow channels into the rotor from the rotor internal flow channel inlet and the rotor internal flow channel outlet on the second surface.

8. The selector valve according to claim 2, characterized in that: The second access hole is provided at any position within the length extension range of the first stator radial slot.

9. The selector valve according to claim 8, characterized in that The second inlet and outlet hole is disposed at the first radius from the rotation axis.

10. The selector valve according to claim 1, wherein: When the rotor rotates relative to the stator to a position where the first stator radial groove is connected to the first rotor radial groove and the second stator radial groove is connected to the rotor internal flow channel outlet, the liquid introduced into the rotary valve from the first inlet and outlet holes flows sequentially through the rotor internal flow channel inlet, the rotor internal flow channel, the rotor internal flow channel outlet, the second stator radial groove, the rotor annular groove, the first rotor radial groove, the first stator radial groove, and the second inlet and outlet holes, thereby achieving flushing of all flow channels inside the selection valve.

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