Acoustic coupling Grignard reagent continuous flow preparation equipment

Abstract

The invention discloses acoustic coupling Grignard reagent continuous flow preparation equipment, and relates to the technical field of Grignard reagents, the acoustic coupling Grignard reagent continuous flow preparation equipment comprises a reaction tank, the reaction tank is used for storing Grignard reagent raw materials, and the reaction speed and efficiency are promoted through an internal stirring assembly; the separation box is fixedly mounted below the reaction tank through a support frame, and the reaction tank is used for carrying out liquid-gas separation on the reacted Grignard reagent raw materials; the purification box is arranged on one side of the reaction tank and the separation box, and the purification box is used for purifying the separated gas and liquid and filtering impurities through an impurity removal assembly. According to the Grignard reagent purification device, through mutual cooperation of the pushing assembly, the impurity removal assembly and the heating rod, impurity removal can be conducted on liquid in a Grignard reagent, gas can be purified again, meanwhile, the gas becomes liquid through heating, purified water mist on the inner wall of the purification box is scraped through a scraping plate, waste caused when the Grignard reagent is manufactured can be effectively avoided, and the production efficiency of the Grignard reagent is improved. The production efficiency of the Grignard reagent is improved.

Description

Technical Field

[0001] The invention relates to the technical field of Grignard reagents, and in particular to a continuous flow preparation device for acoustically coupled Grignard reagents. Background Art

[0002] Grignard reagents, also known as Grignard reagents, are a class of organometallic compounds containing magnesium halides. Since they were first prepared by French chemist Grignard in 1901, they have occupied an important position in organic synthesis. This reagent has a wide range of applications in chemistry, chemical engineering, biomedicine and other fields, and is a key raw material for the synthesis of many important compounds. The acoustically coupled Grignard reagent continuous flow preparation equipment introduces ultrasonic or sonic vibration effects to enhance the mass transfer and heat transfer process, thereby promoting the chemical reaction.

[0003] For example, Chinese patent authorization announcement number CN108889261A discloses a device and control method for preparing Grignard reagent, including: a storage container, a drip rate controller, a reaction container, a condenser, a signal monitoring module, a receiving container, a first pipeline, a second pipeline and a connecting pipeline; the storage container and the drip rate controller are connected through the first pipeline, the first pipeline is connected to the second pipeline, and the reaction container is connected to the upper end of the condenser through the second pipeline; the lower end of the condenser is connected to the reaction container through the connecting pipeline, and a signal monitoring module is provided on the connecting pipeline; the receiving container is located downstream of the reaction container and is connected to the reaction container, and the receiving container is located downstream of the condenser and is connected to the condenser. However, the traditional reactor has low production efficiency and poor contact effect of the mixture. At the same time, the Grignard reagent cannot be purified for a second time after the reaction is completed, which easily causes waste in the production process. Summary of the invention

[0004] The purpose of the present invention is to provide an acoustically coupled Grignard reagent continuous flow preparation device to solve the problems raised in the above background technology.

[0005] The purpose of the present invention can be achieved through the following technical solutions:

[0006] An acoustically coupled Grignard reagent continuous flow preparation device comprises a reaction tank, wherein the reaction tank is used to store the raw materials of the Grignard reagent and promote the speed and efficiency of the reaction through an internal stirring component;

[0007] A separation box, the separation box is fixedly installed below the reaction tank through a support frame, and the reaction tank is used to separate liquid and gas from the raw materials of the Grignard reagent after the reaction;

[0008] A purification box is arranged on one side of the reaction tank and the separation box, and is used to purify the separated gas and liquid and filter impurities through a de-impurity component.

[0009] As a further solution of the present invention: a feed channel is fixedly installed on one side of the separation box, and a protective plug is slidably connected in the feed channel. The reaction tank and the separation box are connected through a connecting pipe, and a control valve is fixedly installed on the connecting pipe.

[0010] As a further solution of the present invention: the stirring assembly includes a driving motor, the driving motor is fixed on the reaction tank, the output end of the driving motor is fixedly connected to a rotating shaft 1, and the rotating shaft 1 is fixedly connected to a gear 1, and the gear 1 is meshedly connected to a gear 2, and the middle part of the gear 2 is fixedly connected to the rotating shaft 2;

[0011] A stirring blade 1, wherein the stirring blade 1 is provided in multiple groups and is fixed on a rotating shaft 1;

[0012] The stirring blades are provided in multiple groups and fixed on the rotating shaft.

[0013] As a further solution of the present invention: the gear 1 and the gear 2 are arranged at the gap of the end cover of the reaction tank, and the rotating shaft 2 and the rotating shaft 1 are both movably connected to one side of the reaction tank.

[0014] As a further solution of the present invention: a guide plate is fixed in the separation box, an air pump is fixedly installed on one side of the separation box, and one end of the air pump is fixedly connected to an air pipe, and the side of the air pipe away from the air pump is fixedly installed on the top of the purification box, a water pump is fixedly installed on the other side of the separation box, and one end of the water pump is fixedly connected to a water pipe, and the side of the water pipe away from the water pump is fixed in the purification box.

[0015] As a further solution of the present invention: a guide plate 2 is fixedly installed in the purification box, a water pump 2 is fixedly installed on one side of the purification box, and a discharge pipe is fixedly connected to one end of the discharge pipe, a limit rod is fixedly installed on one side of the purification box, limit rods are fixed on both sides of the purification box, and a pushing assembly is installed on the purification box.

[0016] As a further solution of the present invention: a decontamination component is slidably mounted on one side of the purification box.

[0017] As a further solution of the present invention: the impurity removal assembly includes a connection frame, the connection frame is slidably connected to the limit rod, a sealing plate is fixedly connected to one side of the connection frame, and the sealing plate is slidably connected to one side of the purification box;

[0018] A filter screen, the filter screen is fixed in the connection frame, and the filter screen is used to filter impurities in the liquid in the purification box;

[0019] An activated carbon plate is fixed in the connection frame and arranged below the filter screen, and is used to absorb odor in the purification box.

[0020] As a further solution of the present invention: the pushing assembly includes a bidirectional motor, the bidirectional motor is fixed on the purification box, the output end of the bidirectional motor is fixedly connected to a transmission shaft, and worms are fixed on both sides of the surface of the transmission shaft, and one side of the worm is meshedly connected with a worm wheel, and a reciprocating screw is fixed in the middle of the worm wheel;

[0021] A sliding block, wherein the sliding block is threadedly connected to the surface of the reciprocating screw rod, and a scraper is fixedly connected to one side of the sliding block;

[0022] The limiting plates are provided in two groups and are fixed on both sides of the purification box.

[0023] As a further solution of the present invention: the reciprocating screw is movably connected to one side of the purification box, the worm is movably connected to the middle of the limit plate, the scraper is slidably connected in the purification box, the sliding block slides through the slide grooves opened on both sides of the purification box, and the reciprocating screw is installed in the slide grooves opened on both sides of the purification box.

[0024] Beneficial effects of the present invention:

[0025] (1) In the present invention, the liquid in the Grignard reagent can be decontaminated and the gas can be purified again by the cooperation between the pushing component, the impurity removal component and the heating rod. At the same time, the gas is heated to become a liquid, and the water mist purified on the inner wall of the purification box is scraped by the scraper, which can effectively avoid the waste caused by the production of Grignard reagent and improve the efficiency of Grignard reagent production;

[0026] (2) In the present invention, the stirring assembly and the ultrasonic generator are used to stir and vibrate the raw materials in the reaction tank, thereby promoting the reaction, improving the reaction efficiency and product purity, making the reaction of the Grignard reagent raw materials more efficient, promoting the mixing and contact of the reactants, and accelerating the reaction process, thereby realizing continuous and stable production of the Grignard reagent, improving production efficiency, and reducing production costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] The present invention will be further described below in conjunction with the accompanying drawings.

[0028] Figure 1 The three-dimensional structure of the acoustic coupling Grignard reagent continuous flow preparation device of the present invention is shown in FIG. Figure 1 ;

[0029] Figure 2 The three-dimensional structure of the acoustic coupling Grignard reagent continuous flow preparation device of the present invention is shown in FIG. Figure 2 ;

[0030] Figure 3 It is a schematic cross-sectional structure diagram of the acoustically coupled Grignard reagent continuous flow preparation device of the present invention;

[0031] Figure 4 It is a schematic diagram of the three-dimensional structure of the stirring assembly of the present invention;

[0032] Figure 5 It is a three-dimensional structural schematic diagram of the pushing assembly of the present invention;

[0033] Figure 6 yes Figure 5 The enlarged view of point A in the middle;

[0034] Figure 7 is an exploded view of the impurity removal component of the present invention;

[0035] Figure 8 It is a schematic diagram of the partial internal structure of the purification box of the present invention.

[0036] In the figure: 1, reaction tank; 2, separation box; 3, purification box; 4, stirring assembly; 5, pushing assembly; 6, impurity removal assembly; 7, feed channel; 8, protective plug; 9, support frame; 10, connecting pipe; 11, control valve; 12, air pump; 13, air pipe; 14, water pump 1; 15, water pipe; 16, guide plate 1; 17, guide plate 2; 18, water pump 2; 19, discharge pipe; 20, limit rod; 400, drive motor ; 401, gear one; 402, shaft one; 403, stirring blade one; 404, gear two; 405, shaft two; 406, stirring blade two; 500, bidirectional motor; 501, transmission shaft; 502, worm; 503, worm wheel; 504, reciprocating screw; 505, limit plate; 506, sliding block; 507, scraper; 600, connecting frame; 601, filter screen; 602, activated carbon plate; 603, sealing plate. DETAILED DESCRIPTION

[0037] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0038] Embodiment 1

[0039] See also Figure 1-Figure 8 As shown, the present invention is an acoustically coupled Grignard reagent continuous flow preparation device, comprising a reaction tank 1, the reaction tank 1 is used to store Grignard reagent raw materials and promote the speed and efficiency of the reaction through an internal stirring component 4;

[0040] A separation box 2, the separation box 2 is fixedly installed below the reaction tank 1 through a support frame 9, and the reaction tank 1 is used to perform liquid-gas separation on the raw materials of the Grignard reagent after the reaction;

[0041] The purification box 3 is arranged on one side of the reaction tank 1 and the separation box 2 . The purification box 3 is used to purify the separated gas and liquid and filter the impurities through the impurity removal component 6 .

[0042] It should be noted that a sound wave generator is fixedly installed inside the reaction tank 1 , and the sound wave generator is a prior art and is electrically connected and controlled by external wireless signal transmission. The sound wave generator can generate non-sound wave vibrations on the raw materials of the reaction tank 1 .

[0043] In the present invention, preferably, a feed channel 7 is fixedly installed on one side of the separation box 2, and a protective plug 8 is slidably connected in the feed channel 7. The reaction tank 1 and the separation box 2 are connected through a connecting pipe 10, and a control valve 11 is fixedly installed on the connecting pipe 10.

[0044] It should be noted that one side of the connecting pipe 10 is fixed in the separation box 2, and the other side of the connecting pipe 10 is fixed in the reaction tank 1. The material of the protective plug 8 is rubber material and a groove is provided on one side to prevent the feed channel 7 from being blocked.

[0045] In the present invention, preferably, the stirring assembly 4 includes a driving motor 400, the driving motor 400 is fixed on the reaction tank 1, the output end of the driving motor 400 is fixedly connected to a rotating shaft 1 402, and the rotating shaft 1 402 is fixedly connected to a gear 1 401, and the gear 1 401 is meshedly connected to a gear 2 404, and the middle part of the gear 2 404 is fixedly connected to a rotating shaft 2 405;

[0046] A stirring blade 403, wherein the stirring blade 403 is provided in multiple groups and is fixed on the rotating shaft 402;

[0047] The second stirring blade 406 is provided with multiple groups and is fixed on the second rotating shaft 405 .

[0048] It should be noted that the stirring blade 1 403 and the stirring blade 2 406 are arranged in a staggered manner to avoid interference between the stirring blade 1 403 and the stirring blade 2 406 during rotation.

[0049] In the present invention, preferably, gear one 401 and gear two 404 are arranged at the gap of the end cover of the reaction tank 1, and the second shaft 405 and the first shaft 402 are both movably connected to one side of the reaction tank 1.

[0050] It should be noted that the specific connection relationship between the second rotating shaft 405 , the first rotating shaft 402 and the reaction tank 1 is a rotational connection, and a limiting disk is fixed on one side of the second rotating shaft 405 , and the limiting disk rotates on the reaction tank 1 .

[0051] In the present invention, preferably, a guide plate 16 is fixed in the separation box 2, an air pump 12 is fixedly installed on one side of the separation box 2, and one end of the air pump 12 is fixedly connected to an air pipe 13, and the side of the air pipe 13 away from the air pump 12 is fixedly installed above the purification box 3, and a water pump 14 is fixedly installed on the other side of the separation box 2, and one end of the water pump 14 is fixedly connected to a water pipe 15, and the side of the water pipe 15 away from the water pump 14 is fixed in the purification box 3.

[0052] It should be noted that the guide plate 16 is arranged at an angle, so that the water pump 14 on one side of the separation box 2 is easier to extract. One side of the air pump 12 is connected to the interior of the separation box 2, and one side of the water pump 14 is connected to the interior of the separation box 2.

[0053] To implement the project, first pull the protective plug 8, remove the protective plug 8 along the feed channel 7, put halogenated hydrocarbons, metal magnesium (usually in the form of magnesium chips or magnesium powder), solvents (such as anhydrous ether or tetrahydrofuran) and other raw materials into the reaction tank 1 through the feed channel 7, put the protective plug 8 in the feed channel 7 for protection, set the drive motor 400, the output end of the drive motor 400 rotates with the shaft 1 402, the shaft 1 402 rotates with the gear 1 401, the shaft 1 402 rotates with the stirring blade 1 403, the gear 1 401 rotates with the gear 2 404 along the gap of the reaction tank 1 in the opposite direction, the gear 2 404 rotates with the reverse shaft 2 405, the shaft 2 405 rotates with the reverse stirring blade 2 406, the stirring blade 1 403 rotates forward and the stirring blade 2 406 rotates in the opposite direction. The raw materials in the reaction tank 1 are stirred in both directions, and an ultrasonic generator is set inside the reaction tank 1 to generate vibration inside the reaction tank 1, so that the Grignard reagent raw material reacts more efficiently, promotes the mixing and contact of the reactants, and accelerates the reaction process. After the reaction of the Grignard reagent raw material in the reaction tank 1 is completed, the control valve 11 is opened to allow the Grignard reagent raw material to react and fall into the separation box 2 through the connecting pipe 10. The liquid in the Grignard reagent raw material in the separation box 2 falls to the guide plate 16 due to gravity, and the gas in the Grignard reagent raw material in the separation box 2 rises inside the separation box 2. An air pump 12 is set, and the air pump 12 transports the gas in the separation box 2 into the purification box 3 through the air pipe 13. A water pump 14 is set, and the water pump 14 transports the liquid in the separation box 2 into the purification box 3 through the water pipe 15.

[0054] Embodiment 2

[0055] In the present invention, preferably, a guide plate 17 is fixedly installed in the purification box 3, a water pump 18 is fixedly installed on one side of the purification box 3, and a discharge pipe 19 is fixedly connected to one end of the discharge pipe 19, a limiting rod 20 is fixedly installed on one side of the purification box 3, and limiting rods 20 are fixed on both sides of the purification box 3, and a pushing assembly 5 is installed on the purification box 3.

[0056] It should be noted that the guide plate 17 is arranged at an angle, and the guide plate 17 is convenient for guiding the liquid inside the purification box 3 to the connection between the water pump 18 and the purification box 3. A heating rod is fixedly installed in the purification box 3. The heating rod is a prior art and is electrically connected. The heating rod is controlled by external wireless signal transmission. The heating rod can heat the purification box 3 to heat the internal gas into liquid and then purify it.

[0057] In the present invention, preferably, a de-impurity component 6 is slidably mounted on one side of the purification box 3 .

[0058] In the present invention, preferably, the impurity removal component 6 includes a connection frame 600, the connection frame 600 is slidably connected to the limit rod 20, a sealing plate 603 is fixedly connected to one side of the connection frame 600, and the sealing plate 603 is slidably connected to one side of the purification box 3;

[0059] Filter 601, which is fixed in the connection frame 600 and is used to filter impurities in the liquid in the purification box 3;

[0060] The activated carbon plate 602 is fixed in the connection frame 600 and arranged below the filter screen 601 . The activated carbon plate 602 is used to absorb the odor in the purification box 3 .

[0061] It should be noted that the sealing plate 603 is made of rubber to facilitate blocking one side of the purification box 3, and a hand-pulled groove is provided on one side of the sealing plate 603 for easy pulling, and tiny holes are provided inside the activated carbon plate 602 for easy liquid circulation.

[0062] In the present invention, preferably, the pushing assembly 5 includes a bidirectional motor 500, which is fixed on the purification box 3, and the output end of the bidirectional motor 500 is fixedly connected with a transmission shaft 501, and worms 502 are fixed on both sides of the surface of the transmission shaft 501, and one side of the worm 502 is meshedly connected with a worm wheel 503, and a reciprocating screw 504 is fixed in the middle of the worm wheel 503;

[0063] A sliding block 506, the sliding block 506 is threadedly connected to the surface of the reciprocating screw rod 504, and a scraper 507 is fixedly connected to one side of the sliding block 506;

[0064] The limiting plates 505 are provided in two groups and are fixed on both sides of the purification box 3 .

[0065] It should be noted that the scraper 507 fits closely with the inner wall of the purification box 3 to facilitate scraping the water mist inside the purification box 3.

[0066] In the present invention, preferably, the reciprocating screw 504 is movably connected to one side of the purification box 3, the worm 502 is movably connected to the middle of the limit plate 505, the scraper 507 is slidably connected in the purification box 3, the sliding block 506 slides through the slide grooves opened on both sides of the purification box 3, and the reciprocating screw 504 is installed in the slide grooves opened on both sides of the purification box 3.

[0067] During the implementation process, the liquid entering the purification box 3 falls on the filter screen 601, and after impurities are filtered, it passes through the activated carbon plate 602 for adsorption and then flows out through the small holes. The liquid falls on the guide plate 17 and finally flows to the connection between the water pump 18 and the purification box 3. A heating rod is set in the purification box 3. The heating rod in the purification box 3 heats the inside of the purification box 3 to heat and purify the gas in the purification box 3. The gas in the purification box 3 is heated to become liquid, and passes through the filter screen 601 and the activated carbon plate 602 by gravity to remove impurities and finally flows to the connection between the water pump 18 and the purification box 3. A bidirectional motor 500 is set, and the output end of the bidirectional motor 500 rotates with the transmission shaft 501, and the transmission shaft 501 rotates along the middle of the limit plate 505 with two sets of worms 502, and the worm 502 rotates along the reaction tank 1 with the worm wheel 503. 503 rotates with the reciprocating screw 504, and the rotation of the two groups of reciprocating screws 504 causes the two groups of sliding blocks 506 to move up and down through the limit of the purification box 3 along the reciprocating screw 504 and the slide grooves opened on both sides of the purification box 3, and then scrape the water mist inside the purification box 3 up and down, so that the water mist on the inner wall of the purification box 3 is scraped off and passes through the filter screen 601 and the activated carbon plate 602 for impurity removal, and finally flows to the connection between the water pump 2 18 and the purification box 3, so that the liquid in the Grignard reagent can be impurity-removed and the gas can be purified again, and the scraper 507 is used to scrape the purified water mist on the inner wall of the purification box 3, which can effectively avoid waste during the production of Grignard reagent and improve the efficiency of Grignard reagent production. A water pump 2 18 is set, and the water pump 2 18 extracts the impurity-removed Grignard reagent liquid through the discharge pipe 19, and opens the limit rod 20 to discharge the gas that cannot be purified in the purification box 3.

[0068] The above is a detailed description of an embodiment of the present invention, but the content is only a preferred embodiment of the present invention and cannot be considered to limit the scope of implementation of the present invention. All equivalent changes and improvements made within the scope of the present invention should still fall within the scope of the patent coverage of the present invention.

Claims

1. Acoustically coupled Grignard reagent continuous flow preparation equipment, characterized in that: The invention comprises a reaction tank (1), wherein the reaction tank (1) is used for storing raw materials of a Grignard reagent and promoting the speed and efficiency of the reaction through an internal stirring component (4); A separation box (2), wherein the separation box (2) is fixedly installed below the reaction tank (1) via a support frame (9), and the reaction tank (1) is used to perform liquid-gas separation on the raw material of the Grignard reagent after the reaction; A purification box (3) is arranged on one side of the reaction tank (1) and the separation box (2), and is used to purify the separated gas and liquid and filter impurities through a de-impurity component (6).

2. The acoustically coupled Grignard reagent continuous flow preparation device according to claim 1, characterized in that: A feed channel (7) is fixedly installed on one side of the separation box (2), and a protective plug (8) is slidably connected in the feed channel (7). The reaction tank (1) and the separation box (2) are connected through a connecting pipe (10), and a control valve (11) is fixedly installed on the connecting pipe (10).

3. The acoustically coupled Grignard reagent continuous flow preparation device according to claim 1, characterized in that: The stirring assembly (4) comprises a driving motor (400), the driving motor (400) is fixed on the reaction tank (1), the output end of the driving motor (400) is fixedly connected to a rotating shaft 1 (402), and the rotating shaft 1 (402) is fixedly connected to a gear 1 (401), and the gear 1 (401) is meshedly connected to a gear 2 (404), and the middle part of the gear 2 (404) is fixedly connected to a rotating shaft 2 (405); A stirring blade (403), wherein the stirring blade (403) is provided in multiple groups and is fixed on the rotating shaft (402); A second stirring blade (406), wherein the second stirring blade (406) is provided in multiple groups and is fixed on the second rotating shaft (405).

4. The acoustically coupled Grignard reagent continuous flow preparation device according to claim 3, characterized in that: The gear 1 (401) and the gear 2 (404) are arranged at the gap of the end cover of the reaction tank (1), and the rotating shaft 2 (405) and the rotating shaft 1 (402) are both movably connected to one side of the reaction tank (1).

5. The acoustically coupled Grignard reagent continuous flow preparation device according to claim 1, characterized in that: A guide plate (16) is fixed inside the separation box (2); an air pump (12) is fixedly installed on one side of the separation box (2); one end of the air pump (12) is fixedly connected to an air supply pipe (13); at the same time, the side of the air supply pipe (13) away from the air pump (12) is fixedly installed above the purification box (3); a water pump (14) is fixedly installed on the other side of the separation box (2); one end of the water pump (14) is fixedly connected to a water supply pipe (15); at the same time, the side of the water supply pipe (15) away from the water pump (14) is fixed inside the purification box (3).

6. The acoustically coupled Grignard reagent continuous flow preparation device according to claim 1, characterized in that: A guide plate 2 (17) is fixedly installed in the purification box (3), a water pump 2 (18) is fixedly installed on one side of the purification box (3), and one end of the discharge pipe (19) is fixedly connected to the discharge pipe (19), a limit rod (20) is fixedly installed on one side of the purification box (3), and the limit rods (20) are fixed on both sides of the purification box (3), and a pushing assembly (5) is installed on the purification box (3).

7. The acoustically coupled Grignard reagent continuous flow preparation device according to claim 1, characterized in that: A de-impurity component (6) is slidably mounted on one side of the purification box (3).

8. The acoustically coupled Grignard reagent continuous flow preparation device according to claim 7, characterized in that: The impurity removal component (6) comprises a connection frame (600), the connection frame (600) is slidably connected to the limit rod (20), a sealing plate (603) is fixedly connected to one side of the connection frame (600), and the sealing plate (603) is slidably connected to one side of the purification box (3); A filter screen (601), the filter screen (601) is fixed in the connection frame (600), and the filter screen (601) is used to filter impurities in the liquid in the purification box (3); An activated carbon plate (602), wherein the activated carbon plate (602) is fixed in the connection frame (600) and arranged below the filter screen (601), and the activated carbon plate (602) is used to absorb odor in the purification box (3).

9. The acoustically coupled Grignard reagent continuous flow preparation device according to claim 6, characterized in that: The pushing assembly (5) comprises a bidirectional motor (500), the bidirectional motor (500) is fixed on the purification box (3), the output end of the bidirectional motor (500) is fixedly connected to a transmission shaft (501), and worms (502) are fixed on both sides of the surface of the transmission shaft (501), and one side of the worm (502) is meshedly connected to a worm wheel (503), and a reciprocating screw (504) is fixed in the middle of the worm wheel (503); A sliding block (506), wherein the sliding block (506) is threadedly connected to the surface of the reciprocating screw rod (504), and a scraper (507) is fixedly connected to one side of the sliding block (506); The limiting plates (505) are provided in two groups and are fixed on both sides of the purification box (3).

10. The acoustically coupled Grignard reagent continuous flow preparation device according to claim 9, characterized in that: The reciprocating screw (504) is movably connected to one side of the purification box (3), the worm (502) is movably connected to the middle part of the limit plate (505), the scraper (507) is slidably connected inside the purification box (3), the sliding block (506) slides through the slide grooves opened on both sides of the purification box (3), and the reciprocating screw (504) is installed in the slide grooves opened on both sides of the purification box (3).

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