Clonidine patch drug release system and device thereof

Abstract

The invention discloses a clonidine patch drug release system and a device thereof, and belongs to the field of medicines. The storage layer, the controlled release film layer and the pressure-sensitive adhesive layer are sequentially connected from top to bottom, the backing layer is arranged at the upper end of the storage layer, and the protective layer is arranged at the lower end of the pressure-sensitive adhesive layer. The storage layer, the controlled release film layer and the pressure-sensitive adhesive layer are positioned in the round hole, and a plurality of centrosymmetric through holes are formed around the round hole; the expansion layer is fixedly connected to the backing layer and covers the upper end of the circular hole; the expansion layer is provided with two through holes I which are mutually symmetrical and are communicated with the through hole, and the expansion layer is also provided with two through holes II which are mutually symmetrical; an annular connecting ring in sliding fit with the through hole II is arranged in the through hole II; and the connecting ring is fixedly connected with the storage layer. The pressure-sensitive adhesive layer can be effectively prevented from being attached to the same position of the skin of a patient for a long time, irritation to the skin is reduced, the storage layer, the controlled-release film layer and the pressure-sensitive adhesive layer can be effectively wrapped between the backing layer and the expansion layer after use, and pets and children are prevented from swallowing the pressure-sensitive adhesive layer.

Description

Technical Field

[0001] The invention relates to a clonidine patch drug release system and a device thereof, belonging to the field of medicine. Background Art

[0002] When using clonidine patches, care should be taken to avoid sticking them on the same part for a long time to reduce skin irritation. They should be replaced every seven days. After use, the used patches still contain a large amount of clonidine, so they should be properly handled to prevent children and pets from swallowing them by mistake. The old patches should be folded in half and discarded out of reach of children. The current clonidine patches are fixed on the skin after use, which can irritate the skin for a long time. Moreover, after use, the skin secretes oil, which reduces the stickiness of the patches after they are removed. Even after being folded in half, the drug-releasing part may still be exposed due to insufficient stickiness, which is especially easy for pet dogs to swallow by mistake. Therefore, it is necessary to improve them. Summary of the invention

[0003] The purpose of the present invention is to solve the above problems existing in the background technology and to provide a clonidine patch drug release system and device thereof.

[0004] The present invention achieves the above-mentioned purpose by adopting the following technical solutions:

[0005] A clonidine patch drug release system comprises a backing layer, a reservoir layer, a controlled release membrane layer, a pressure-sensitive adhesive layer and a protective layer; the reservoir layer, the controlled release membrane layer and the pressure-sensitive adhesive layer are sequentially connected from top to bottom, the backing layer is arranged at the upper end of the reservoir layer, and the protective layer is arranged at the lower end of the pressure-sensitive adhesive layer.

[0006] A clonidine patch drug release device, the device clonidine patch drug release system also includes an expansion layer; a circular hole is provided at the center of the backing layer, a reservoir layer, a controlled release membrane layer and a pressure-sensitive adhesive layer are located in the circular hole, and a plurality of centrally symmetrical perforations are provided around the circular hole; the expansion layer is fixedly connected to the backing layer and covers the upper end of the circular hole; two mutually symmetrical through holes I are provided on the expansion layer and are connected to the perforations, and two mutually symmetrical through holes II are also provided on the expansion layer; an annular connecting ring that slidably cooperates with the through hole II is provided in the through hole II; the connecting ring is fixedly connected to the reservoir layer.

[0007] Compared with the prior art, the present invention has the following beneficial effects: the present invention can not only effectively prevent the pressure-sensitive adhesive layer from being attached to the same position of the patient's skin for a long time, thereby reducing irritation to the skin, but also, after use, can effectively wrap the reservoir layer, the controlled-release membrane layer and the pressure-sensitive adhesive layer between the backing layer and the expansion layer, thereby preventing pets and children from swallowing them. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] Figure 1 It is a front cross-sectional view of a clonidine patch drug release device of the present invention;

[0009] Figure 2 It is a top view of a backing layer of a clonidine patch drug release device of the present invention;

[0010] Figure 3 It is a schematic diagram of the connection structure between the backing layer and the locking ring of a clonidine patch drug release device of the present invention;

[0011] Figure 4 is a top view of an expansion layer of a clonidine patch drug release device of the present invention;

[0012] Figure 5 It is a cross-sectional view of a locking device of a clonidine patch drug-releasing device of the present invention;

[0013] Figure 6 It is a structural schematic diagram of a connecting ring of a clonidine patch drug release device of the present invention;

[0014] Figure 7 It is a structural schematic diagram of a clonidine patch drug release system of the present invention. DETAILED DESCRIPTION

[0015] The technical solution of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0016] Specific implementation method 1: Figure 1-7 As shown, this embodiment describes a clonidine patch drug release system, including a backing layer 1, a reservoir layer 8, a controlled release membrane layer 7, a pressure-sensitive adhesive layer 6 and a protective layer 2; the reservoir layer 8, the controlled release membrane layer 7 and the pressure-sensitive adhesive layer 6 are connected in sequence from top to bottom, the backing layer 1 is arranged at the upper end of the reservoir layer 8, and the protective layer 2 is arranged at the lower end of the pressure-sensitive adhesive layer 6. Clonidine can be slowly and continuously released into the skin, and then absorbed into the blood circulation to achieve a therapeutic effect. This drug release system ensures the stable release of the drug and improves the patient's medication compliance and therapeutic effect.

[0017] A clonidine patch drug release device, the device comprises the clonidine patch drug release system as claimed in claim 1, and also comprises an expansion layer 3; a circular hole 11 is provided at the center of the backing layer 1, a reservoir layer 8, a controlled release membrane layer 7 and a pressure-sensitive adhesive layer 6 are located in the circular hole 11, and a plurality of centrally symmetrical perforations 12 are provided around the circular hole 11; the expansion layer 3 is fixedly connected to the backing layer 1 and covers the upper end of the circular hole 11; two mutually symmetrical through holes I 31 are provided on the expansion layer 3 and communicate with the perforations 12, and two mutually symmetrical through holes II 33 are also provided on the expansion layer 3; an annular connecting ring 5 is provided in the through hole II 33 and is slidably matched therewith; the connecting ring 5 is fixedly connected to the reservoir layer 8. The connecting ring 5 can drive the reservoir layer 8, the controlled release membrane layer 7 and the pressure-sensitive adhesive layer 6 to move, so that the patient will not always irritate a certain part of the skin when taking the medicine.

[0018] The cross-sectional area of ​​the circular hole 11 is larger than the cross-sectional areas of the reservoir layer 8 , the controlled release membrane layer 7 and the pressure-sensitive adhesive layer 6 , so that the reservoir layer 8 , the controlled release membrane layer 7 and the pressure-sensitive adhesive layer 6 can move in the circular hole 11 .

[0019] The width of the connecting ring 5 is greater than the diameters of the reservoir layer 8 , the controlled release membrane layer 7 and the pressure-sensitive adhesive layer 6 .

[0020] The expansion layer 3 is also provided with a plurality of ventilation holes 32 for ventilation.

[0021] The invention also includes a locking device 4; the locking device 4 includes a locking ring 43, a sleeve ring 42 and a connecting film 41; the locking ring 43 is slidably matched with a plurality of perforations 12, and the upper end of the locking ring 43 is fixedly connected with the sleeve ring 42 through the connecting film 41; the connecting film 41 passes through the through hole Ⅰ31; and the sleeve ring 42 is sleeved on the connecting ring 5. The locking ring 43 passes through the perforations 12 continuously, so that part of the locking ring 43 is located at the upper end of the backing layer 1, and part of the locking ring 43 is located at the lower end of the backing layer 1, and then when the connecting film 41 is pulled, the folds of the peripheral part of the circular hole 11 of the backing layer 1 can be pulled by the locking ring 43 and attached together, so that the reservoir layer 8, the controlled release membrane layer 7 and the pressure-sensitive adhesive layer 6 are sealed between the expansion layer 3 and the folds of the backing layer 1.

[0022] The protective layer 2 is fixedly bonded to the backing layer 1 .

[0023] The backing layer 1 is elastic and adheres to the patient's skin. The backing layer 1 is elastic so that it will not be damaged during sealing, thus preventing the drug from being exposed.

[0024] The expansion layer 3 , the locking device 4 , the connecting ring 5 and the backing layer 1 are made of the same material.

[0025] The working principle of the present invention is as follows: when using the device, the protective layer 2 is peeled off, and then the backing layer 1 is pasted on the patient's skin, and the expansion layer 3 is pressed so that the expansion layer 3 pushes the reservoir layer 8, the controlled release membrane layer 7 and the pressure-sensitive adhesive layer 6 to adhere to the patient's skin. Since the cross-sectional area of ​​the circular hole 11 is larger than the cross-sectional area of ​​the reservoir layer 8, the controlled release membrane layer 7 and the pressure-sensitive adhesive layer 6, when it is necessary to change the position during the trial period, the skin at the position of the circular hole 11 is squeezed to make the skin bulge, thereby facilitating the peeling off of the pressure-sensitive adhesive layer 6, and then the connecting ring 5 is pushed so that the reservoir layer 8, the controlled release membrane layer 7 and the pressure-sensitive adhesive layer 6 fixedly connected under the connecting ring 5 move together in the circular hole 11. After moving to the appropriate position, the expansion layer 3 is pressed again to complete the position exchange, thereby avoiding long-term attachment to one place of the skin to cause irritation.

[0026] After use, the backing layer 1 is peeled off from the skin, and then the connecting film 41 is pulled to move the connecting film 41 away from the backing layer 1, thereby causing the locking ring 43 to deform, and causing the peripheral position of the circular hole 11 on the backing layer 1 to wrinkle and squeeze to one place, so that the wrinkled part of the backing layer 1 and the expansion layer 3 form a sealed airborne storage reservoir layer 8, controlled release membrane layer 7 and pressure-sensitive adhesive layer 6, and then the connecting film 41 is knotted to fix the wrinkled part of the backing layer 1 to prevent the wrinkled part of the backing layer 1 from loosening and causing the reservoir layer 8, controlled release membrane layer 7 and pressure-sensitive adhesive layer 6 to be exposed.

[0027] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other forms of assembly without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered in all respects as exemplary and non-restrictive, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations within the meaning and range of equivalents of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

[0028] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A clonidine patch drug delivery system, characterized in that: The invention comprises a backing layer (1), a reservoir layer (8), a controlled release membrane layer (7), a pressure-sensitive adhesive layer (6) and a protective layer (2); the reservoir layer (8), the controlled release membrane layer (7) and the pressure-sensitive adhesive layer (6) are connected in sequence from top to bottom, the backing layer (1) is arranged at the upper end of the reservoir layer (8), and the protective layer (2) is arranged at the lower end of the pressure-sensitive adhesive layer (6).

2. A clonidine patch drug release device, characterized in that: The device comprises the clonidine patch drug release system as claimed in claim 1, and also comprises an expansion layer (3); a circular hole (11) is provided at the center of the backing layer (1), the reservoir layer (8), the controlled release membrane layer (7) and the pressure-sensitive adhesive layer (6) are located in the circular hole (11), and a plurality of centrally symmetrical perforations (12) are provided around the circular hole (11); the expansion layer (3) is fixedly connected to the backing layer (1) and covers the upper end of the circular hole (11); two mutually symmetrical through holes I (31) are provided on the expansion layer (3) and are connected to the perforations (12), and two mutually symmetrical through holes II (33) are also provided on the expansion layer (3); an annular connecting ring (5) is provided in the through hole II (33) and is slidably matched therewith; the connecting ring (5) is fixedly connected to the reservoir layer (8).

3. A clonidine patch drug release device according to claim 2, characterized in that: The cross-sectional area of ​​the circular hole (11) is larger than the cross-sectional areas of the reservoir layer (8), the controlled release membrane layer (7) and the pressure-sensitive adhesive layer (6).

4. A clonidine patch drug delivery system according to claim 3, characterized in that: The width of the connecting ring (5) is greater than the diameters of the reservoir layer (8), the controlled release membrane layer (7) and the pressure-sensitive adhesive layer (6).

5. A clonidine patch drug release device according to claim 4, characterized in that: The expansion layer (3) is also provided with a plurality of ventilation holes (32).

6. The clonidine patch drug release device according to claim 5, characterized in that: It also includes a locking device (4); the locking device (4) includes a locking ring (43), a sleeve ring (42) and a connecting film (41); the locking ring (43) is slidably matched with a plurality of through holes (12), and the upper end of the locking ring (43) is fixedly connected to the sleeve ring (42) via the connecting film (41); the connecting film (41) passes through the through hole I (31); and the sleeve ring (42) is sleeved on the connecting ring (5).

7. A clonidine patch drug release device according to claim 6, characterized in that: The protective layer (2) is fixedly connected to the backing layer (1).

8. The clonidine patch drug release device according to claim 7, characterized in that: The backing layer (1) is elastic and adheres to the patient's skin.

9. The clonidine patch drug release device according to claim 8, characterized in that: The expansion layer (3), the locking device (4), the connecting ring (5) and the backing layer (1) are made of the same material.

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