White light compensation method of targeted light source for treating depression and application

Abstract

The invention relates to the field of depression adjuvant therapy, in particular to a white light compensation method of a targeted light source for treating depression and application. According to the invention, the natural attribute characteristics of the targeted spectrum of the LED light source are adjusted and applied to the adjustment of the biological rhythm and seasonal affective disorder symptoms of the depression, so that a spectrum technical scheme is provided for an auxiliary means of drug therapy for treating the depression. Aiming at the special targeted spectrum and application, firstly, intelligent control and adjustment of illumination wavelength, illumination measurement, optimal action mode and natural attribute characteristics of the targeted spectrum of an LED light source technology are integrated in a phototherapy instrument or device for adjusting the biological rhythm of depression; on the basis of the phototherapy instrument or device for adjusting the biological rhythm of the depression, a targeted spectrum setting and blue light prevention white light compensation method is carried out, so that the instrument or device for adjusting the biological rhythm of the depression can provide more accurate light formula requirements.

Description

Technical Field

[0001] The present invention relates to the field of auxiliary treatment of depression, and in particular to a white light compensation method and application of a targeted light source for treating depression. Background Art

[0003] The method of using artificial or natural light sources to prevent and treat diseases. Since the 1980s, some scholars have tried to use light to treat seasonal depression. Currently, the means of treating depression include drug therapy, psychotherapy and physical therapy, but they all have limitations to varying degrees. For example, drug therapy has side effects, slow onset, and may not be effective for all patients. As a form of physical therapy, light therapy has been shown in clinical trials to relieve different types of depressive symptoms. Researchers have found that reduced daylight disrupts the physiological rhythm that controls the secretion of melatonin, leading to biological clock disorders and causing mood and sleep problems. However, these symptoms can disappear in some patients after receiving 15 to 30 minutes of special wavelength artificial strong light exposure every day. In the Chinese Guidelines for the Treatment of Depression Disorders, light therapy is an important means of physical therapy, which can correct the disrupted biological rhythm of patients with depression and adjust the serotonin and catecholamine systems, and it is stated that the treatment is usually effective within 1-3 weeks. Light therapy has attracted wide attention for its advantages of being non-invasive, having few side effects, and having rapid efficacy, and it provides new possibilities for regulating symptoms such as biorhythms of depression and sleep disorders. Light signals are projected to the depressed brain area through retinal ganglion cells to participate in non-visual imaging functions, activate nerve cell activities, secrete neurotransmitters to cause physiological changes in neural pathways, and regulate the circadian rhythm, mood, and sleep of the biological body, thereby achieving the purpose of improving depressive behavior. The wavelength, dosage, and optimal mode of action of light are closely related to the therapeutic effect, but the side effects of the current application mode and spectrum of light therapy on the body of patients with depression cannot be completely avoided and there are still discussions and studies. In order to comprehensively promote the application of light therapy in the field of life sciences and clinical practice, the present invention provides a spectral technology solution for auxiliary means of drug treatment of depression by adjusting the natural property characteristics of the targeted spectrum of the LED light source and applying it to regulate the biorhythms of depression and seasonal affective disorder symptoms.

[0004] The basic principle of LED light therapy for depression: using non-imaging visual function methods to treat depression. In addition to participating in the formation of vision, light therapy also has non-imaging visual functions, such as improving mood, enhancing memory, and relieving pain. Light therapy converts light signals into electrical signals through the retina and then transmits them to the central nervous system to exert its effects. Intrinsic photosensitive ganglion cells (ipRGC) play an important role in the visual non-imaging system and participate in the regulation of circadian rhythms, emotions, cognition and other functions. Light therapy exerts antidepressant effects through photosensitive neural circuits, such as the ipRGC-lateral geniculate body-lateral stiff nucleus pathway. Light therapy improves depression by regulating monoamine neurotransmitters, such as reducing the function of 5-HT transporters, reducing the reuptake of 5-HT, and increasing the level of 5-HT in the synaptic cleft. Light therapy can inhibit the pineal gland by activating ipRGCs, reduce the synthesis and release of melatonin during the day, and restore the biological clock to homeostasis.

[0005] LED light therapy for depression treatment methods and technical means: Most clinical studies use full-spectrum white light, and a few other studies use monochromatic light such as blue light and green light for treatment. Blue light (460-480nm) is the most powerful synchronizer of the circadian rhythm system. Blue light therapy can significantly improve the depressive symptoms of patients with seasonal depression. White light with high color temperature contains more short-wave components and has a more significant impact on human emotions. ipRGCs are more sensitive to short-wavelength blue light. Bright light therapy (BLT) can play a significant antidepressant effect on both seasonal and non-seasonal depression. Light exerts its antidepressant effect in a dose-dependent manner. With 30-120 minutes of light per day and a treatment cycle lasting 2-5 weeks, the patient's depression can be significantly improved. Taking advantage of the adjustable and intelligent LED spectrum, different dimensions of light are integrated according to the needs of different occasions and time periods, bringing people a comfortable experience and creating a light environment that is conducive to physical and mental health. These methods and technical means for treating depression constitute the technical means of LED light therapy for depression, providing a new treatment option for patients with depression. Summary of the invention

[0006] Based on this, the purpose of the present invention is to provide a white light compensation method and application of a targeted light source for treating depression, which is specifically applied to a physical light therapy instrument or device that can exert a significant antidepressant effect on seasonal or non-seasonal depression through bright light therapy (BLT). The advantages of LED spectrum being adjustable and intelligent are utilized to integrate targeted spectra of different dimensions according to the needs of different occasions and time periods.

[0007] The present invention adopts the following technical solution:

[0008] A white light compensation method for a targeted light source for treating depression, the compensation method using a physical light therapy instrument or device for treating depression, the compensation method further comprising the following steps:

[0009] S1. Targeted spectrum design for visual training based on myopia suppression: The physical phototherapy instrument or device includes a light source, the spectrum of which includes a blue light spectrum with a peak wavelength of 460-480nm, a green light spectrum with a peak wavelength of 530-560nm, a red light spectrum with a peak wavelength of 680-710nm, and a white light mixed spectrum with a peak wavelength of 380-780nm;

[0010] The technology uses blue light spectrum plus green light spectrum to excite yellow phosphor to produce white light, and then mixes a certain proportion of red light spectrum. Based on the principle of spectral superposition, LED mixed arrays with different proportions of blue light spectrum, green light spectrum and red light spectrum are used. By adjusting the proportion of different LED components, the mixed output spectrum can be controlled to establish a suitable targeted light source, while reducing or eliminating the blue light spectrum in white light that is harmful to the body of patients with depression;

[0011] S2. Design and production of a physical light therapy instrument or device for targeted spectrum treatment of depression: The physical light therapy instrument or device uses a combination of a constant current power supply and a light homogenizer to disperse light energy while maintaining a stable energy output; the physical light therapy instrument or device uses Android studio as the development environment, a quad-core ARM Cortex-A53 architecture chip development board as the host computer, and combines blue, green, red, and white light LED light source modules to achieve control of the targeted spectrum for treating depression. A pulse width modulation ESP32 chip is used for communication with the LED light source module. After the user logs in, the user information is transmitted to the device screen for display, and the training records in the device are uploaded to the server at the same time, so as to achieve cloud storage of depression treatment records;

[0012] S3. The light source of the instrument or device for targeted spectral treatment of depression consists of: red light zone, white light zone, blue light zone, and green light zone; the red light zone is composed of red light LED lamps with a wavelength range of 680-710nm; the white light zone is composed of LED lamps with a luminous color temperature of 6000-12000K; the blue light zone is composed of blue light LED lamps with a wavelength range of 460-480nm; the green light zone is composed of green light LED lamps with a wavelength range of 530-560nm;

[0013] S4. The light source sets targeted performance indicators. Based on the technology of monochromatic blue light LED compensating white light LED, the joint state density function of photons in two-dimensional space is used as the spectral radiation model of monochromatic LED to establish an LED simulation database.

[0014] A further improvement to the above technical solution is that the integral value of the luminous intensity of the light of the blue light spectrum with a peak wavelength of 460-480nm is recorded as A; the integral value of the luminous intensity of the light of the green light spectrum with a peak wavelength of 530-560nm is recorded as B; the integral value of the luminous intensity of the light of the red light spectrum with a peak wavelength of 680-710nm is recorded as C; the integral value of the luminous intensity of the light of the white light mixed spectrum with a peak wavelength of 380-780nm is recorded as D; the typical ratio of the integral values ​​is A:B:C:D=30:5:15:50.

[0015] A further improvement to the above technical solution is that, in the spectrum of the targeted light source, in the range of 380-780nm, 45-55% presents white light emission in the range of 512-616nm, 25-35% presents blue light emission in the range of 460-480nm, 5% presents green light emission in the range of 530-560nm, and 10-20% presents red light emission in the range of 680-710nm; the light emission is white light, and its color coordinates are set to X=0.265-0.285, Y=0.275-0.295.

[0016] A further improvement to the above technical solution is that the physical light therapy instrument or device for treating depression includes a power supply module, a control module, a first drive module, a second drive module, a third drive module, a red light emitting module, a white light emitting module and a blue light emitting module.

[0017] A further improvement to the above technical solution is to set the illumination parameters of the white light area, blue light area and red light area, including illumination and illumination timing: the illumination of the red light area is set to 300Lx, and it is continuously bright; the illumination of the white light area is set to 10000Lx and 5000Lx, and the illumination timing is alternating between 10000Lx for 30 minutes and 5000Lx for 60 minutes; the illumination of the blue light area is set to 100Lx, and it is continuously bright.

[0018] A further improvement to the above technical solution is that the light source sets a targeted performance index, where the illumination intensity of the LED light source is reduced to 50% of the maximum intensity, and the illumination time of the light source to reach the illumination guide value is doubled. This linear relationship can be applied to determine the time for a combination of multiple light sources to reach the illumination guide value at different intensities; where, at an illumination measurement distance of 40 inches, the power density of the blue LED spectrum of 460-480nm and 27nm half-peak bandwidth is ≥100μW / cm 2 The guidance value of radiation exposure for the visual effect of targeted light sources on patients with depression is 12-18 J / cm 2 .

[0019] A further improvement to the above technical solution is to establish a mathematical model of the spectrum of a monochromatic LED using the photon joint state density function in a two-dimensional space based on the energy distribution in the semiconductor material, and the expression is as follows:

[0020]

[0021] Among them, λ represents the wavelength of light, S(λ) value represents the spectral radiation intensity, and A, λc1, λc2, ω1, and ω2 are fitting parameters.

[0022] A further improvement to the above technical solution is to use a white light LED mixed with three monochromatic lights, blue light, green light and red light, to simulate the visible light part of the spectrum of the targeted light source, and its spectral distribution can be expressed by the following formula:

[0023]

[0024] where Φ s (λ) represents the spectral energy distribution in the visible light range of the targeted light source spectrum, Φ(λ) represents the spectral energy distribution of the white light LED of the targeted light source, Φ i (λ)(i=1, 2, 3, ..., n) represents the energy distribution of the blue, green and red monochromatic LED spectrum, k i =a i ·n i ((i=1, 2, 3, ..., n), n i Indicates the number of i-th LEDs required for the simulation results of the targeted light source, a i is the conversion coefficient between the LED spectral radiation intensity and the driving current. In the simulation process, all LEDs are assumed to work at the rated voltage, so a i = 1. Therefore, if the absolute spectral distribution is used, k i =n i It can be used to represent the number of the i-th type of LEDs required, and the generalized solution of the coefficient matrix k can be obtained through least squares programming. LED (i) An LED spectrum matrix constructed by mixing white light LEDs and monochromatic LEDs.

[0025] A further improvement to the above technical solution is to select the relevant index R in the simulation design and experiment. 2 As a parameter for evaluating the effect of different combinations of blue, green and red monochromatic LEDs on the spectrum fitting of the targeted light source, it is calculated as follows:

[0026]

[0027] In the formula, y is the target value, y e is the estimated value, n is the number of data points, R 2≤1. The closer its value is to 1, the better the fit between the estimated value and the target value.

[0028] The invention discloses an application of a white light compensation method for a targeted light source for treating depression, wherein the compensation method is applied to regulating or intervening in the biological rhythm of depression and the symptoms of seasonal affective disorder.

[0029] The beneficial effects of the present invention are:

[0030] The luminous spectrum of the luminous source radiation light of the present invention, based on strong light phototherapy, can increase the content of 5-HT between synapses by improving the transport efficiency of 5-HT transporter, and play an antidepressant effect. The non-visual effect of light shows that illumination, especially short-wave blue light near 460-480nm, stimulates 5-HT neurons by ipRGC to affect its neurotransmitter secretion, thereby affecting the striatum and amygdala in the prefrontal cortex area, and then affects biological rhythm and seasonal affective disorder depression symptoms adjustment. Meanwhile, weak light irradiation such as red spectrum (especially the red spectrum of 680-710nm) can significantly reduce Aβ plaque volume and quantity in cerebral cortex and hippocampus, effectively alleviates adverse reactions such as memory and cognitive impairment, emotional instability, loss of function, and also has certain significant effect on regulating depression biological rhythm and seasonal affective disorder depression symptoms.

[0031] The targeted light source compensation method for treating depression adopts dynamic adjustment of spectral distribution, real-time monitoring of spectral output, intelligent compensation algorithm, and balanced optimization of blue light stimulation intensity. The key technologies of the targeted light source for treating depression are precise spectral control, physiological feedback monitoring, and personalized spectral matching.

[0032] In the instrument or device based on regulating or intervening biological rhythms and seasonal affective disorder depressive symptoms, in the spectrum model of the targeted light source for treating depression, light therapy is performed under white light (5000-10000Lux, CCT=6000-12000K) by exciting yellow phosphor and blue light (460-480nm) plus green light (530-560nm). Blue light and broad-spectrum strong light are effective in improving short-light cycle-induced depression behavior, and ipRGC participates in the antidepressant effect of photobiological regulation. Among them, the light with a wavelength of 460nm has the most obvious inhibitory effect on melatonin in the body, while still maintaining the effectiveness of treatment. However, the illumination time, illumination intensity, frequency, etc. of strong light and blue light have not reached the target light source standard of consistency. The side effects caused by improper parameter selection to the body of patients with depression cannot be completely avoided. White light contains a spectrum that is harmful to the body of patients with depression, and patients may feel uncomfortable and produce adverse reactions such as eye fatigue. Therefore, the present invention filters the harmful spectrum in white light through the white light compensation method of the targeted light source, thereby avoiding adverse reactions to patients with depression. For blue light therapy, harmful blue light in white light, especially 440-455nm blue light, can penetrate the lens directly to the retina, and produce free radicals in the retina, causing retinal pigment epithelial cell decay, so that the light-sensitive area lacks nutrients and photosensitive cells die, leading to fundus lesions, decreased vision, temporary blindness of the eyes, etc., and mild mania occurs in blue light therapy, including other common side effects mainly including eye fatigue, nausea, excitement and migraine induction. Therefore, the precise selection of the wavelength and spectral properties of the targeted light source of the present invention and the adaptability of the light intensity are key factors in regulating the biorhythm of depression and the depressive symptoms of seasonal affective disorder.

[0033] The light sources in the instruments or devices for regulating or intervening in the biorhythms of depression and the depressive symptoms of seasonal affective disorder need to set targeted performance indicators. Based on the technology of monochromatic blue light LED compensating white light LED, the joint state density function of photons in two-dimensional space is used as the spectral radiation model of monochromatic LED to establish an LED simulation database. Based on the light therapy spectrum requirements that affect the adjustment of biorhythms and seasonal affective disorder symptoms, the blue light spectrum plus the green light spectrum is used to excite the yellow phosphor to produce white light technology, and then a certain proportion of the red spectrum is mixed. Based on the principle of spectral superposition, LED mixed arrays with different proportions of blue light spectrum, green light spectrum and red light spectrum are used. By adjusting the proportions of different LED components, the control of the mixed output spectrum can be achieved, and a suitable targeted light source is established to regulate or intervene in the biorhythms of depression and the depressive symptoms of seasonal affective disorder, while reducing or eliminating the blue light spectrum contained in white light that is harmful to the body of patients with depression. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1A schematic diagram of the light source targeting spectrum for treating depression according to the present invention;

[0035] Figure 2 It is a schematic diagram of the spectrum of ordinary LED and natural light of the present invention.

[0036] Description of reference numerals:

[0037] A. Blue light spectrum (460-480nm peak wavelength spectrum);

[0038] B. Green light spectrum (530-560nm peak wavelength spectrum);

[0039] C, red light spectrum (680-710nm peak wavelength spectrum);

[0040] D. White light spectrum (380-780nm white light mixed spectrum). DETAILED DESCRIPTION

[0041] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0042] In the description of the present invention, it should be noted that the terms "vertical direction", "up", "down", "horizontal", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, "first", "second", "third", and "fourth" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0043] In the description of the present invention, it is also necessary to explain that, unless otherwise clearly specified and limited, the terms "set", "install", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection, it can be a mechanical connection, it can be an electrical connection, it can be a direct connection, it can be connected through an intermediate medium, and it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0044] like Figure 1 to Figure 2As shown, an embodiment of the present invention relates to a white light compensation method of a targeted light source for treating depression. The compensation method uses a physical light therapy instrument or device for treating depression. The compensation method also includes the following steps:

[0045] S1. Targeted spectrum design for visual training based on myopia suppression: The physical phototherapy instrument or device includes a light source, the spectrum of which includes a blue light spectrum with a peak wavelength of 460-480nm, a green light spectrum with a peak wavelength of 530-560nm, a red light spectrum with a peak wavelength of 680-710nm, and a white light mixed spectrum with a peak wavelength of 380-780nm;

[0046] The technology uses blue light spectrum plus green light spectrum to excite yellow phosphor to produce white light, and then mixes a certain proportion of red light spectrum. Based on the principle of spectral superposition, LED mixed arrays with different proportions of blue light spectrum, green light spectrum and red light spectrum are used. By adjusting the proportion of different LED components, the mixed output spectrum can be controlled to establish a suitable targeted light source, while reducing or eliminating the blue light spectrum in white light that is harmful to the body of patients with depression;

[0047] S2. Design and production of a physical light therapy instrument or device for targeted spectrum treatment of depression: The physical light therapy instrument or device uses a combination of a constant current power supply and a homogenizer to disperse light energy while maintaining a stable energy output; the physical light therapy instrument or device uses Android studio as the development environment, a quad-core ARM Cortex-A53 architecture chip development board as the host computer, and combines blue, green, red, and white light LED light source modules to achieve control of the targeted spectrum for treating depression, uses a pulse width modulation ESP32 chip for communication with the LED light source module, transmits user information to the device screen for display after the user logs in, and simultaneously uploads the training records in the device to the server to achieve cloud storage of depression treatment records; the main depression treatment function in the LED light source module of this device is realized by normalizing the spectrum of blue, green, red, and white light, adopts the constant current principle method to use a constant current power supply as the driving unit, and places a homogenizer in front of the LED light source module, and the homogenizer diffuses the light spot in the LED light source module while uniformly outputting the spectral photon energy;

[0048] S3. The light source of the instrument or device for targeted spectral treatment of depression is composed of: a red light zone, a white light zone, a blue light zone, and a green light zone; the red light zone is composed of red light LED lamps with a wavelength range of 680-710nm; the white light zone is composed of LED lamps with a luminous color temperature of 6000-12000K; the blue light zone is composed of blue light LED lamps with a wavelength range of 460-480nm; the green light zone is composed of green light LED lamps with a wavelength range of 530-560nm; the targeted spectrum for depression treatment used in the present invention meets the national standards of my country for spectral irradiation of the human retina.

[0049] S4. The light source sets targeted performance indicators. Based on the technology of monochromatic blue light LED compensating white light LED, the joint state density function of photons in two-dimensional space is used as the spectral radiation model of monochromatic LED to establish an LED simulation database.

[0050] The ratio of the absolute value of the difference between the target spectrum and the simulated spectrum to the target spectrum. The parameter ratio can be used to evaluate the effect of the light source simulating the spectrum. The smaller the ratio, the higher the similarity of the two spectra.

[0051] Furthermore, the integral value of the luminous intensity of the light of the blue light spectrum with a peak wavelength of 460-480nm is recorded as A; the integral value of the luminous intensity of the light of the green light spectrum with a peak wavelength of 530-560nm is recorded as B; the integral value of the luminous intensity of the light of the red light spectrum with a peak wavelength of 680-710nm is recorded as C; the integral value of the luminous intensity of the light of the white light mixed spectrum with a peak wavelength of 380-780nm is recorded as D; and the typical ratio of the integral values ​​is A:B:C:D=30:5:15:50.

[0052] Furthermore, in the spectrum of the targeted light source, in the range of 380-780nm, 45-55% presents white light emission in the range of 512-616nm, 25-35% presents blue light emission in the range of 460-480nm, 5% presents green light emission in the range of 530-560nm, and 10-20% presents red light emission in the range of 680-710nm; the luminescent light is white light, and its color coordinates are set to X=0.265-0.285, Y=0.275-0.295.

[0053] Furthermore, the physical light therapy instrument or device for treating depression includes a power supply module, a control module, a first driving module, a second driving module, a third driving module, a red light emitting module, a white light emitting module and a blue light emitting module. The control module is used to execute the irradiation method, and each light-emitting module is controlled by the main control chip, display unit, decoder and clock signal generating module; in each light-emitting module, the white light zone and the blue light zone mainly provide targeted lighting brightness for treating depression and realize specific functional spectrum; the red light zone provides color temperature adjustment, scene atmosphere and white light compensation; the connection relationship of each light-emitting module adopts parallel connection to ensure independent control of each light zone, and is respectively connected in series with the power supply module for unified power management, and the signal bus of each light zone is connected to realize linkage and coordinated control; the drive design scheme adopts constant current drive chip, PWM dimming technology, integrated over-temperature protection circuit, and reserved independent adjustment interface at the hardware level; at the software level, the partition independent control algorithm, brightness gradient smoothing processing, multi-mode scene switching, and communication protocol compatibility design are adopted; by adopting STM32 / ESP32 microcontroller, I2C / SPI communication interface, and TI / SILICON drive chip, the characteristics of the whole system are realized, and the characteristics of modular design, high reliability and intelligent linkage are realized.

[0054] Furthermore, the illumination parameters of the white light area, blue light area and red light area are set, including illumination and illumination timing: the illumination of the red light area is set to 300Lx, and it is continuously bright; the illumination of the white light area is set to 10000Lx and 5000Lx, and the illumination timing is alternating between 10000Lx for 30 minutes and 5000Lx for 60 minutes; the illumination of the blue light area is set to 100Lx, and it is continuously bright.

[0055] Furthermore, the light source sets a targeted performance index, where the illumination intensity of the LED light source is reduced to 50% of the maximum intensity, and the illumination time of the light source to reach the illumination guide value is doubled. This linear relationship can be applied to determine the time for a combination of multiple light sources to reach the illumination guide value at different intensities; where, at an illumination measurement distance of 40 inches, the power density of the blue LED spectrum of 460-480nm and 27nm half-peak bandwidth is ≥100μW / cm 2 The guidance value of radiation exposure for the visual effect of targeted light sources on patients with depression is 12-18 J / cm 2 .

[0056] Furthermore, in order to optimize the results of the targeted light source simulation for depression treatment, the present invention proposes a targeted spectrum simulation method based on white light LED compensation technology, which uses a white light LED and a mixture of three monochromatic LEDs with spectral energy distributions of blue light (460-480nm), green light (530-560nm) and red light (680-710nm) and adjusts the number of different LEDs lit to achieve the output of the simulated targeted light source spectrum, and achieves the use of blue light (460-480nm) to excite phosphors and a combination of green light (530-560nm) and red light (680-710nm) to reproduce the spectrum of the targeted light source to varying degrees, which has certain guiding significance for practice. In order to fully characterize the spectral distribution characteristics of monochromatic LEDs, the present invention selects the joint state density function of photons in two-dimensional space established based on the energy distribution in semiconductor materials as the mathematical model of the spectrum of monochromatic LEDs, and its expression is as follows:

[0057]

[0058] Among them, λ represents the wavelength of light, S(λ) value represents the spectral radiation intensity, and A, λc1, λc2, ω1, and ω2 are fitting parameters.

[0059] Furthermore, a white light LED is mixed with three monochromatic lights, blue light, green light and red light, to simulate the visible light part of the spectrum of the targeted light source. Its spectral distribution can be expressed by the following formula:

[0060]

[0061] where Φ s (λ) represents the spectral energy distribution in the visible light range of the targeted light source spectrum, Φ(λ) represents the spectral energy distribution of the white light LED of the targeted light source, Φ i (λ)(i=1, 2, 3, ..., n) represents the energy distribution of the blue, green and red monochromatic LED spectrum, k i =a i ·n i ((i=1, 2, 3, ..., n), n i Indicates the number of i-th LEDs required for the simulation results of the targeted light source, a i is the conversion coefficient between the LED spectral radiation intensity and the driving current. In the simulation process, all LEDs are assumed to work at the rated voltage, so a i = 1. Therefore, if the absolute spectral distribution is used, k i =n i It can be used to represent the number of the i-th type of LEDs required, and the generalized solution of the coefficient matrix k can be obtained through least squares programming. LED (i) An LED spectrum matrix constructed by mixing white light LEDs and monochromatic LEDs.

[0062] Furthermore, in the simulation design and experiment, the correlation index R is selected 2 As a parameter for evaluating the effect of different combinations of blue, green and red monochromatic LEDs on the spectrum fitting of the targeted light source, it is calculated as follows:

[0063]

[0064] In the formula, y is the target value, y e is the estimated value, n is the number of data points, R 2 ≤1, the closer the value is to 1, the better the fit between the estimated value and the target value. LED is used to simulate the target light source spectrum of the required light source. Spectral matching is to use LEDs with different peak wavelengths and half-width to match the target spectrum of the required light source. It is also the inversion of the spectrum. The light emitted by a certain number of LED arrays with different monochromatic colors is fully mixed, and the proportion of the corresponding monochromatic light in the mixed light is changed by adjusting the radiation flux of the LED to simulate the design of the targeted spectrum for the treatment of depression.

[0065] The invention discloses an application of a white light compensation method for a targeted light source for treating depression, wherein the compensation method is applied to regulating or intervening in the biological rhythm of depression and the symptoms of seasonal affective disorder.

[0066] The present invention proposes an optimization combination technology for achieving target spectrum matching by using a spectrum matching algorithm based on the requirements of engineering practice, and uses monochromatic LEDs with different peak wavelengths and half-widths and a targeted spectrum for depression treatment to calculate the optimal LED combination ratio. Using simulation experiment results and design, the technology of using blue light spectrum plus green light spectrum to excite yellow phosphor to produce white light, and then mixing a certain proportion of red spectrum, the fitting errors are relatively small. The simulation experiment results and design illustrate that the monochromatic LED is fully capable of quantitatively matching the targeted spectrum of the required light source. The data of the known targeted spectrum can infer the numerical ratio of monochromatic LEDs of different wavelengths. The light radiation emitted by a certain number of LEDs of different monochromatic colors can also be fully mixed, and the mixed spectrum can be compared with the targeted spectrum and fitted to achieve the adjustment of the radiant brightness of the LED, thereby changing the ratio of the corresponding monochromatic light in the mixed light, and finally changing the spectrum of the mixed light. The method of the invention is simple and easy to operate, has a fast running speed, high fitting efficiency, small mismatch error, high accuracy, etc., and provides a brand-new method for the development of lamps for treating depression based on LED light sources.

[0067] The above only expresses the preferred technical solution of the present invention, and its description is relatively specific and detailed, but it cannot be understood as limiting the scope of the invention patent. It should be pointed out that for ordinary technicians in this field, several modifications and improvements can be made without departing from the concept of the present invention, and the present invention is also intended to include these modifications and modifications.

Claims

1. A white light compensation method for a targeted light source for treating depression, characterized in that: The compensation method uses a physical light therapy instrument or device for treating depression, and the compensation method also includes the following steps: S1. Targeted spectrum design for visual training based on myopia suppression: The physical phototherapy instrument or device includes a light source, the spectrum of which includes a blue light spectrum with a peak wavelength of 460-480nm, a green light spectrum with a peak wavelength of 530-560nm, a red light spectrum with a peak wavelength of 680-710nm, and a white light mixed spectrum with a peak wavelength of 380-780nm; The technology uses blue light spectrum plus green light spectrum to excite yellow phosphor to produce white light, and then mixes a certain proportion of red light spectrum. Based on the principle of spectral superposition, LED mixed arrays with different proportions of blue light spectrum, green light spectrum and red light spectrum are used. By adjusting the proportion of different LED components, the mixed output spectrum can be controlled to establish a suitable targeted light source, while reducing or eliminating the blue light spectrum in white light that is harmful to the body of patients with depression; S2. Design and production of a physical light therapy instrument or device for targeted spectrum treatment of depression: The physical light therapy instrument or device uses a combination of a constant current power supply and a light homogenizer to disperse light energy while maintaining a stable energy output; the physical light therapy instrument or device uses Android studio as the development environment, a quad-core ARM Cortex-A53 architecture chip development board as the host computer, and combines blue, green, red, and white light LED light source modules to achieve control of the targeted spectrum for treating depression. A pulse width modulation ESP32 chip is used for communication with the LED light source module. After the user logs in, the user information is transmitted to the device screen for display, and the training records in the device are uploaded to the server at the same time, so as to achieve cloud storage of depression treatment records; S3. The light source of the instrument or device for targeted spectral treatment of depression consists of: red light zone, white light zone, blue light zone, and green light zone; the red light zone is composed of red light LED lamps with a wavelength range of 680-710nm; the white light zone is composed of LED lamps with a luminous color temperature of 6000-12000K; the blue light zone is composed of blue light LED lamps with a wavelength range of 460-480nm; the green light zone is composed of green light LED lamps with a wavelength range of 530-560nm; S4. The light source sets targeted performance indicators. Based on the technology of monochromatic blue light LED compensating white light LED, the joint state density function of photons in two-dimensional space is used as the spectral radiation model of monochromatic LED to establish an LED simulation database.

2. The white light compensation method of the targeted light source for treating depression according to claim 1, characterized in that: The integral value of the luminous intensity of the light of the blue light spectrum with a peak wavelength of 460-480nm is recorded as A; the integral value of the luminous intensity of the light of the green light spectrum with a peak wavelength of 530-560nm is recorded as B; the integral value of the luminous intensity of the light of the red light spectrum with a peak wavelength of 680-710nm is recorded as C; the integral value of the luminous intensity of the light of the white light mixed spectrum with a peak wavelength of 380-780nm is recorded as D; the typical ratio of the integral values ​​is A:B:C:D=30:5:15:

50.

3. The white light compensation method of the targeted light source for treating depression according to claim 1, characterized in that: In the spectrum of the targeted light source, in the range of 380-780nm, 45-55% presents white light emission in the range of 512-616nm, 25-35% presents blue light emission in the range of 460-480nm, 5% presents green light emission in the range of 530-560nm, and 10-20% presents red light emission in the range of 680-710nm; the light emission is white light, and its color coordinates are set to X=0.265-0.285, Y=0.275-0.

295.

4. The white light compensation method of the targeted light source for treating depression according to claim 1, characterized in that: The physical light therapy instrument or device for treating depression includes a power supply module, a control module, a first driving module, a second driving module, a third driving module, a red light emitting module, a white light emitting module and a blue light emitting module.

5. The white light compensation method of the targeted light source for treating depression according to claim 1, characterized in that: Set the illumination parameters of the white light area, blue light area and red light area, including illumination and illumination timing: the illumination of the red light area is set to 300Lx, and it is continuously bright; the illumination of the white light area is set to 10000Lx and 5000Lx, and the illumination timing is alternating between 10000Lx for 30 minutes and 5000Lx for 60 minutes; the illumination of the blue light area is set to 100Lx, and it is continuously bright.

6. The white light compensation method of the targeted light source for treating depression according to claim 1, characterized in that: The light source sets the targeted performance index, where the illumination intensity of the LED light source is reduced to 50% of the maximum intensity, and the illumination time of the light source to reach the illumination guide value is doubled. This linear relationship can be applied to determine the time for the combination of multiple light sources to reach the illumination guide value at different intensities; where, at an illumination measurement distance of 40 inches, the power density of the blue LED spectrum of 460-480nm and 27nm half-peak bandwidth is ≥100μW / cm 2 The guidance value of radiation exposure for the visual effect of targeted light sources on patients with depression is 12-18 J / cm 2 .

7. The white light compensation method of the targeted light source for treating depression according to claim 1, characterized in that: The mathematical model of the spectrum of a monochromatic LED is established based on the energy distribution of photons in semiconductor materials and the joint state density function in two-dimensional space. The expression is as follows: Among them, λ represents the wavelength of light, S(λ) value represents the spectral radiation intensity, and A, λc1, λc2, ω1, and ω2 are fitting parameters.

8. The white light compensation method of the targeted light source for treating depression according to claim 1, characterized in that: The visible light part of the spectrum of the targeted light source is simulated by mixing white light LED with three monochromatic lights: blue light, green light and red light. Its spectral distribution can be expressed by the following formula: where Φ s (λ) represents the spectral energy distribution in the visible light range of the targeted light source spectrum, Φ(λ) represents the spectral energy distribution of the white light LED of the targeted light source, Φ i (λ)(i=1, 2, 3, ..., n) represents the energy distribution of the blue, green and red monochromatic LED spectrum, k i =a i ·n i ((i=1, 2, 3, ..., n), n i Indicates the number of i-th LEDs required for the simulation results of the targeted light source, a i is the conversion coefficient between the LED spectral radiation intensity and the driving current. In the simulation process, all LEDs are assumed to work at the rated voltage, so a i = 1. Therefore, if the absolute spectral distribution is used, k i =n i It can be used to represent the number of the i-th type of LEDs required, and the generalized solution of the coefficient matrix k can be obtained through least squares programming. LED (i) An LED spectrum matrix constructed by mixing white light LEDs and monochromatic LEDs.

9. The white light compensation method of the targeted light source for treating depression according to claim 1, characterized in that: In simulation design and experiments, the correlation index R is selected 2 As a parameter for evaluating the effect of different combinations of blue, green and red monochromatic LEDs on the spectrum fitting of the targeted light source, it is calculated as follows: In the formula, y is the target value, y e is the estimated value, n is the number of data points, R 2 ≤1. The closer its value is to 1, the better the fit between the estimated value and the target value.

10. An application of a white light compensation method for a targeted light source for treating depression, characterized in that: The compensation method as described in any one of claims 1 to 9 is used to regulate or intervene in the biorhythms of depression and seasonal affective disorder symptoms.

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