Water-locking magnet containing saccharide isomeride and preparation method of water-locking magnet

Abstract

The invention relates to the field of water-locking magnets, and provides a water-locking magnet containing saccharide isomeride and a preparation method thereof, the water-locking magnet comprises the following raw materials by weight: 55-70 parts of saccharide isomeride, 4-10 parts of tartaric acid, 0.5-3 parts of modified ellagic acid, and 40-60 parts of deionized water. The water-locking magnet containing the saccharide isomeride provided by the invention has the characteristics of efficient moisturizing and allergy resistance.

Description

Technical Field

[0001] The invention relates to the field of water-locking magnets, and in particular to a water-locking magnet containing sugar isomers and a preparation method thereof. Background Art

[0002] Saccharide isomerate is a sugar isomer, a natural moisturizer extracted from sugarcane sugar complex, which can be used as a water retainer and emollient, and has the function of repairing epidermal cells and improving the skin's ability to replenish water to achieve a moisturizing effect. It is called a water-locking magnet because it can bind to the ε amino acid functional group on the skin, just like a magnet, and can maintain the water magnetic field ability of the skin for a long time. Due to its unique moisturizing ingredients, water-locking magnets have begun to be widely used in moisturizing and emollient cosmetics. Currently, some mainstream cosmetics contain this ingredient. Some R&D staff have also conducted some research on the development of multifunctional water-locking magnets and the use of water-locking magnets in cosmetics.

[0003] Although water-locking magnets already have the above-mentioned excellent properties, their moisturizing properties still have a lot of room for improvement based on sugar substances alone. In addition, ordinary water-locking magnets only have water-retaining and moisturizing properties, and do not have anti-allergic and antioxidant properties, and still have great application limitations.

[0004] Patent CN 113876613 A discloses a water-locking magnet containing lactobionic acid, and its preparation method and application, which contains the following components by mass: 50-60% carbohydrate isomers, 30-40% water, and 1-10% lactobionic acid. It has good water-locking ability, can improve the moisture balance of the skin, make the skin softer and smoother without making the skin feel greasy, protect the skin, prevent the skin from itching or roughness due to dryness, and also has good safety, no irritation, and no cytotoxicity. However, the water-locking magnet is limited to some extent in some high-moisturizing fields by the moisturizing effect of sugar substances alone. Although the water-locking magnet is non-toxic and safe, it does not have anti-allergic properties and may be unfriendly to people with sensitive skin, which limits its application scope to some extent.

[0005] Therefore, there is an urgent need in the market for a water-locking magnet containing sugar isomers with high-efficiency moisturizing and anti-allergic properties. Summary of the invention

[0006] In view of the problems existing in the prior art, the present invention uses sugar isomers and fruit acid as main ingredients, and designs to add modified ellagic acid and anti-allergic plant extracts to synthesize a water-locking magnet containing sugar isomers, which has efficient moisturizing and anti-allergic properties.

[0007] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0008] On one hand, the present invention provides a water-locking magnet containing carbohydrate isomers, which comprises the following raw materials: 55-70 parts of carbohydrate isomers, 4-10 parts of fruit acid, 0.5-3 parts of modified ellagic acid, and 40-60 parts of deionized water.

[0009] In some embodiments of the present invention, the carbohydrate isomers are a mixture of D-galactose, D-glucose, D-fructose, D-trehalose and D-mannose.

[0010] In some embodiments of the present invention, the mass ratio of D-galactose, D-glucose, D-fructose, D-trehalose and D-mannose is 1:(20-30):(25-35):(2.0-3.0):(2.5-3.5).

[0011] Preferably, the mass ratio of D-galactose, D-glucose, D-fructose, D-trehalose and D-mannose is 1:22:27:2.5:3.

[0012] In some embodiments of the present invention, the fruit acid is at least one of lactobionic acid, maltobionic acid, and gluconic acid.

[0013] In some embodiments of the present invention, the method for preparing the modified ellagic acid comprises the following steps:

[0014] Add ellagic acid to polyethylene glycol, stir, then add to aqueous sodium hydroxide solution, stir, add β-cyclodextrin, stir, distill under reduced pressure, add aqueous hydrochloric acid solution to adjust pH to 0.5-1.5, let stand at 2-6°C, filter, wash, and dry to obtain modified ellagic acid.

[0015] In some embodiments of the present invention, the mass ratio of ellagic acid to β-cyclodextrin is 1:(14-16).

[0016] Preferably, the mass ratio of ellagic acid to β-cyclodextrin is 1:15.

[0017] Ellagic acid is a natural polyphenol diester component, which is widely present in a variety of plant tissues. Due to its unique chemical and physiological activities, it has excellent properties such as moisturizing, anti-oxidation, anti-aging, anti-ultraviolet and whitening, which gives it good application prospects in the field of cosmetics. However, ellagic acid has poor water solubility and fat solubility, which greatly limits its effective improvement of the moisturizing, anti-oxidation and other properties of the water-locking magnet when added to the water-locking magnet.

[0018] The applicant first selected polyethylene glycol, which has good solubility for ellagic acid, as a solvent. Furthermore, the applicant used β-cyclodextrin as the object and ellagic acid as the host, and included ellagic acid with β-cyclodextrin to obtain modified ellagic acid. The hydrophobic inner cavity and surface hydrophilic structure of β-cyclodextrin enable it to not only stably combine with ellagic acid, but also effectively improve the water solubility of ellagic acid, so that ellagic acid has good solubility in the water-locking magnet system, thereby effectively improving the moisturizing and antioxidant properties of the water-locking magnet.

[0019] In some embodiments of the present invention, 1-4 parts of anti-allergic plant extracts are further included by weight.

[0020] In some embodiments of the present invention, the method for preparing the anti-allergic plant extract comprises the following steps:

[0021] (1) Drying and crushing cactus, sophora flavescens and ophiopogon japonicus respectively, and sieving to obtain cactus powder, sophora flavescens powder and ophiopogon japonicus powder for later use;

[0022] (2) Add the Sophora flavescens powder and Ophiopogon japonicus powder of step (1) into deionized water, stir at 90-100° C. for 1-2 h, cool to 40-50° C., add the cactus powder of step (1), stir, cool to room temperature, coarse filter, centrifuge, take the supernatant, fine filter, concentrate, and freeze-dry to obtain an anti-allergic plant extract.

[0023] In some embodiments of the present invention, in step (2), the mass ratio of Sophora flavescens powder, Ophiopogon japonicus powder and Opuntia cactus powder is 1:(2-4):(6.5-7.5).

[0024] Preferably, in step (2), the mass ratio of Sophora flavescens powder, Ophiopogon japonicus powder and Opuntia cochinchinensis powder is 1:3:7.

[0025] Ordinary water-locking magnets on the market only have the function of moisturizing, that is, they have the limitation of single performance. For example, they do not have anti-allergic properties. Therefore, for people with sensitive skin, water-locking magnets cannot be used alone without worry. Therefore, it is very important to add a certain amount of anti-allergic substances to the water-locking magnets.

[0026] The applicant selected natural, environmentally friendly, mild and non-irritating plant ingredients to prepare anti-allergic plant extracts, and unexpectedly found that using three plant ingredients, namely cactus, sophora flavescens and ophiopogon japonicus, as raw materials and controlling the mass ratio between the three can play a highly efficient and synergistic anti-allergic role.

[0027] Another aspect of the present invention further provides a method for preparing the water-locking magnet containing carbohydrate isomers as described in the above technical solution, comprising the following steps:

[0028] Add sugar isomers, fruit acid, modified ellagic acid and anti-allergic plant extract into deionized water, stir, stir at 75-90° C. for 10-20 minutes, and cool to room temperature to obtain a water-locking magnet containing sugar isomers.

[0029] Compared with the prior art, the present invention has the following beneficial effects:

[0030] (1) The present invention uses carbohydrate isomers and fruit acid as main ingredients, adds modified ellagic acid and anti-allergic plant extracts to synthesize a water-locking magnet containing carbohydrate isomers. Through the synergistic effect of the components, the water-locking magnet has high-efficiency moisturizing and anti-allergic properties.

[0031] (2) The present invention first selects polyethylene glycol with good solubility for ellagic acid as a solvent, and then encapsulates ellagic acid with β-cyclodextrin to obtain modified ellagic acid, thereby effectively improving the water solubility of ellagic acid, thereby effectively promoting the moisturizing and antioxidant properties of the water-locking magnet.

[0032] (3) The present invention uses natural, environmentally friendly, mild and non-irritating plant ingredients to prepare anti-allergic plant extracts, and unexpectedly found that using the plant ingredients of cactus, sophora flavescens and ophiopogon as raw materials and controlling the mass ratio between the three can play a synergistic anti-allergic role.

[0033] (4) The water-locking magnet prepared by the present invention has high-efficiency moisturizing and anti-allergic properties, can be widely used in the field of cosmetics, and has good commercial application value. DETAILED DESCRIPTION

[0034] The present invention will be described below in conjunction with specific embodiments. It should be noted that the following embodiments are examples of the present invention and are only used to illustrate the present invention, but not to limit the present invention. Other combinations and various modifications within the concept of the present invention may be performed without departing from the spirit or scope of the present invention.

[0035] In the following examples and comparative examples, except for modified ellagic acid and anti-allergic plant extracts, the other compound monomers and related reagents used can be purchased from the market, among which the polyethylene glycol is PEG400 purchased from Jinan Yuanlian Chemical Co., Ltd.

[0036] Preparation Example 1

[0037] The synthetic method of modified ellagic acid A comprises the following steps:

[0038] Add 3 g of ellagic acid to 40 ml of polyethylene glycol, stir for 20 min, then add to 30 ml of 1 mol / L sodium hydroxide aqueous solution, stir for 30 min, add 45 g of β-cyclodextrin, stir for 5 h, distill under reduced pressure, add 6 mol / L hydrochloric acid aqueous solution to adjust the pH to 1, let stand at 4 ° C for 12 h, filter, wash with deionized water 3 times, and vacuum dry at 45 ° C for 24 h to obtain modified ellagic acid A.

[0039] Preparation Example 2

[0040] The specific implementation manner of modified ellagic acid B is the same as that of modified ellagic acid A, except that the mass of β-cyclodextrin is replaced with 40 g.

[0041] Preparation Example 3

[0042] The specific implementation manner of modified ellagic acid C is the same as that of modified ellagic acid A, except that the mass of β-cyclodextrin is replaced with 50 g.

[0043] Preparation Example 5

[0044] The synthesis method of the anti-allergic plant extract A comprises the following steps:

[0045] (1) 20 g of cactus was naturally air-dried at 25° C., 20 g of Sophora flavescens and 20 g of Ophiopogon japonicus were dried at 60° C. for 8 h, respectively, and ground, and passed through a 20-mesh sieve to obtain cactus powder, Sophora flavescens powder and Ophiopogon japonicus powder for later use;

[0046] (2) Add 2 g of Sophora flavescens powder and 6 g of Ophiopogon japonicus powder from step (1) to 100 ml of deionized water, stir at 95° C. for 1.5 h, cool to 45° C., add 14 g of cactus powder from step (1), stir for 1 h, cool to room temperature, coarsely filter with a 100-mesh filter, centrifuge, take the supernatant, fine filter with a 1 μm filter rod, concentrate under reduced pressure to 10% of the volume, and freeze-dry at -40° C. for 12 h to obtain antiallergic plant extract A.

[0047] Preparation Example 6

[0048] The specific implementation method of anti-allergic plant extract B is the same as that of anti-allergic plant extract A, except that in step (2), the mass of Ophiopogon japonicus powder is replaced with 3.5 g.

[0049] Preparation Example 7

[0050] The specific implementation method of anti-allergic plant extract C is the same as that of anti-allergic plant extract A, except that in step (2), the mass of cactus powder is replaced with 12 g.

[0051] Example 1

[0052] A water-locking magnet containing sugar isomers. The water-locking magnet comprises the following raw materials: 60 parts of sugar isomers, 7 parts of fruit acid, 2 parts of modified ellagic acid A, 2.5 parts of anti-allergic plant extract A, and 50 parts of deionized water.

[0053] The carbohydrate isomers are a mixture of D-galactose, D-glucose, D-fructose, D-trehalose and D-mannose with a mass ratio of 1:22:27:2.5:3.

[0054] Fruit acid is a mixture of lactobionic acid, maltobionic acid and gluconic acid in a mass ratio of 1:1:1.

[0055] The preparation method of the water-locking magnet containing carbohydrate isomers in this embodiment comprises the following steps:

[0056] Add sugar isomers, fruit acid, modified ellagic acid A and anti-allergic plant extract A into deionized water, stir for 30 minutes, stir at 80°C for 15 minutes, and cool to room temperature to obtain a water-locking magnet containing sugar isomers.

[0057] Example 2

[0058] A water-locking magnet containing sugar isomers. The water-locking magnet comprises the following raw materials: 55 parts of sugar isomers, 4 parts of lactobionic acid, 0.5 parts of modified ellagic acid A, 1 part of anti-allergic plant extract A, and 40 parts of deionized water.

[0059] The carbohydrate isomers are a mixture of D-galactose, D-glucose, D-fructose, D-trehalose and D-mannose with a mass ratio of 1:20:25:2:2.5.

[0060] The preparation method of the water-locking magnet containing carbohydrate isomers in this embodiment comprises the following steps:

[0061] Add sugar isomers, lactobionic acid, modified ellagic acid A and anti-allergic plant extract A into deionized water, stir for 30 minutes, stir at 75°C for 20 minutes, and cool to room temperature to obtain a water-locking magnet containing sugar isomers.

[0062] Example 3

[0063] A water-locking magnet containing sugar isomers. The water-locking magnet comprises the following raw materials: 70 parts of sugar isomers, 10 parts of fruit acid, 3 parts of modified ellagic acid A, 4 parts of anti-allergic plant extract A, and 60 parts of deionized water.

[0064] The carbohydrate isomers are a mixture of D-galactose, D-glucose, D-fructose, D-trehalose and D-mannose with a mass ratio of 1:23:26:2.5:3.5.

[0065] Fruit acid is a mixture of lactobionic acid and maltobionic acid in a mass ratio of 1:1.

[0066] The preparation method of the water-locking magnet containing carbohydrate isomers in this embodiment comprises the following steps:

[0067] Add sugar isomers, fruit acid, modified ellagic acid A and anti-allergic plant extract A into deionized water, stir for 30 minutes, stir at 90° C. for 10 minutes, and cool to room temperature to obtain a water-locking magnet containing sugar isomers.

[0068] Example 4

[0069] A water-locking magnet containing sugar isomers. The water-locking magnet comprises the following raw materials: 60 parts of sugar isomers, 7 parts of fruit acid, 2 parts of modified ellagic acid A, and 50 parts of deionized water.

[0070] The sugar isomers and fruit acids are the same as those in Example 1.

[0071] The preparation method of the water-locking magnet containing carbohydrate isomers in this embodiment comprises the following steps:

[0072] Add sugar isomers, fruit acid and modified ellagic acid A into deionized water, stir for 30 minutes, stir at 90° C. for 10 minutes, and cool to room temperature to obtain a water-locking magnet containing sugar isomers.

[0073] Example 5

[0074] This embodiment provides a water-locking magnet containing sugar isomers and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that modified ellagic acid A is replaced by modified ellagic acid B in equal amounts.

[0075] Example 6

[0076] This embodiment provides a water-locking magnet containing sugar isomers and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that modified ellagic acid A is replaced by modified ellagic acid C in equal amounts.

[0077] Example 7

[0078] This embodiment provides a water-locking magnet containing sugar isomers and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the anti-allergic plant extract B is used to replace the anti-allergic plant extract A in equal amounts.

[0079] Example 8

[0080] This embodiment provides a water-locking magnet containing sugar isomers and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the anti-allergic plant extract A is replaced by an equal amount of the anti-allergic plant extract C.

[0081] Comparative Example 1

[0082] This comparative example provides a water-locking magnet containing sugar isomers and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that ellagic acid is used to replace modified ellagic acid A in equal amounts.

[0083] Performance Testing

[0084] The moisturizing and anti-allergic properties of the water-locking magnets containing carbohydrate isomers described in Examples 1-8 and Comparative Example 1 were tested, and the test results are shown in Table 1.

[0085] (1) Moisturizing properties

[0086] Specific test method: 20 volunteers were coated with the water-locking magnets of Examples 1-8 and Comparative Example 1 on their unilateral forearms and legs, with the coating amount being about 2 mg / cm 2 , twice a day for 4 weeks, and then measurements were taken on the 4th and 6th days after stopping the use of the formula for 3 days. The skin's hydration status was measured by a goniometer to determine the skin's water holding capacity. The increase in skin hydration compared to pre-treatment hydration is expressed as a percentage. The higher the increase in hydration, the better the moisturizing property.

[0087] (2) Anti-allergic properties

[0088] After using the water-locking magnet on human skin for 24 hours, observe whether there are allergic symptoms. If the skin has no itching, redness or swelling, it is "no allergic symptoms"; if the skin has itching, slight redness and swelling, but no obvious redness or swelling, erythema, or edema, it is "mild allergic symptoms"; if the skin has obvious erythema, edema, papules, large (small) blisters, it is "allergic symptoms".

[0089] Table 1

[0090] Group Hydration increase (%) Do you have allergic symptoms? Example 1 40 No allergic symptoms Example 2 38 No allergic symptoms Example 3 35 No allergic symptoms Example 4 32 Have mild allergic symptoms Example 5 26 No allergic symptoms Example 6 25 No allergic symptoms Example 7 30 Have mild allergic symptoms Example 8 31 Have mild allergic symptoms Comparative Example 1 22 No allergic symptoms

[0091] It can be seen from the data in Table 1 that the water-locking magnets in Examples 1-3 of the present invention have good moisturizing and anti-allergic properties as a whole. Among them, Examples 5-6 change the ratio between ellagic acid and β-cyclodextrin in the synthesis process of modified ellagic acid, so that the water solubility of modified ellagic acid is not well improved, which leads to a decrease in the moisturizing performance of the water-locking magnet, but does not affect the anti-allergic performance; Examples 7-8 change the addition ratio of Ophiopogon powder and cactus powder in the synthesis process of anti-allergic plant extracts, so that the synergistic anti-allergic performance between anti-allergic plant extracts decreases, thereby causing the anti-allergic performance of the water-locking magnet to decrease to a certain extent, but does not affect the moisturizing performance; Comparative Example 1 and Example 4 are respectively ellagic acid replacing modified ellagic acid A in equal amounts and no anti-allergic plant extract A is added. Tests found that the moisturizing performance of the water-locking magnet in Comparative Example 1 showed poor results, and the anti-allergic performance of the water-locking magnet in Example 4 showed poor results.

[0092] The above implementation modes are only for illustrating the technical concept and features of the present invention, and their purpose is to enable people familiar with this technology to understand the content of the present invention and implement it, and they cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the protection scope of the present invention.

Claims

1. A water-locking magnet containing sugar isomers, characterized in that: The water-locking magnet comprises the following raw materials in parts by weight: 55-70 parts of saccharide isomers, 4-10 parts of fruit acid, 0.5-3 parts of modified ellagic acid, and 40-60 parts of deionized water.

2. The water-locking magnet containing carbohydrate isomers according to claim 1, characterized in that: The saccharide isomers are a mixture of D-galactose, D-glucose, D-fructose, D-trehalose and D-mannose.

3. The water-locking magnet containing carbohydrate isomers according to claim 2, characterized in that: The mass ratio of D-galactose, D-glucose, D-fructose, D-trehalose and D-mannose is 1:(20-30):(25-35):(2.0-3.0):(2.5-3.5).

4. The water-locking magnet containing carbohydrate isomers according to claim 1, characterized in that: The fruit acid is at least one of lactobionic acid, maltobionic acid and gluconic acid.

5. The water-locking magnet containing carbohydrate isomers according to claim 1, characterized in that: The preparation method of the modified ellagic acid comprises the following steps: Add ellagic acid to polyethylene glycol, stir, then add to aqueous sodium hydroxide solution, stir, add β-cyclodextrin, stir, distill under reduced pressure, add aqueous hydrochloric acid solution to adjust pH to 0.5-1.5, let stand at 2-6°C, filter, wash, and dry to obtain modified ellagic acid.

6. The water-locking magnet containing carbohydrate isomers according to claim 5, characterized in that: The mass ratio of ellagic acid to β-cyclodextrin is 1:(14-16).

7. The water-locking magnet containing carbohydrate isomers according to claim 1, characterized in that: By weight, the invention also comprises 1-4 parts of anti-allergic plant extracts.

8. The water-locking magnet containing carbohydrate isomers according to claim 7, characterized in that: The preparation method of the anti-allergic plant extract comprises the following steps: (1) Drying and crushing cactus, sophora flavescens and ophiopogon japonicus respectively, and sieving to obtain cactus powder, sophora flavescens powder and ophiopogon japonicus powder for later use; (2) Add the Sophora flavescens powder and Ophiopogon japonicus powder of step (1) into deionized water, stir at 90-100° C. for 1-2 h, cool to 40-50° C., add the cactus powder of step (1), stir, cool to room temperature, coarse filter, centrifuge, take the supernatant, fine filter, concentrate, and freeze-dry to obtain an anti-allergic plant extract.

9. The water-locking magnet containing carbohydrate isomers according to claim 8, characterized in that: In the step (2), the mass ratio of Sophora flavescens powder, Ophiopogon japonicus powder and Opuntia cactus powder is 1:(2-4):(6.5-7.5).

10. A method for preparing a water-locking magnet containing carbohydrate isomers according to any one of claims 7 to 9, characterized in that: The following steps are involved: Add sugar isomers, fruit acid, modified ellagic acid and anti-allergic plant extract into deionized water, stir, stir at 75-90° C. for 10-20 minutes, and cool to room temperature to obtain a water-locking magnet containing sugar isomers.