Composition with instant tightening and long-acting anti-wrinkle functions as well as preparation method and application of composition

Abstract

The invention relates to an instant tightening and long-acting anti-wrinkle composition as well as a preparation method and application thereof. The anti-aging composition is prepared from collagen, microprotein and coated hyaluronic acid in a mass ratio of (0.00001-0.5): (0.00001-3): (0.01-5). Compared with the prior art, the firming and anti-wrinkle composition has the advantages that the collagen, the micro-protein and the wrapped hyaluronic acid are combined for use, the formed firming and anti-wrinkle composition better achieves the effects of immediate firming and long-acting wrinkle resistance from different action targets, can be used as an anti-wrinkle active component, and is high in permeability and safety when being applied to cosmetic preparation and use; the anti-wrinkle effect is good.

Description

Technical Field

[0001] The invention relates to the field of cosmetics, and in particular to a composition with instant firming and long-lasting wrinkle resistance, and a preparation method and application thereof. Background Art

[0002] Aging is accompanied by the gradual loss of multiple organs, structures and functions, among which the skin is the largest organ in the human body. The structure of the skin mainly includes the epidermis, dermis and subcutaneous tissue. The structure and function of the epidermis and dermis are closely related to skin aging. The epidermis provides the first line of defense and provides an important barrier function; the dermis is the innermost structural layer of the skin, which participates in the homeostatic regulation, sensory perception, temperature maintenance and other functions of the skin, while maintaining the elasticity and toughness of the skin. The main components are the extracellular matrix including collagen and elastin. Collagen occupies more than 70% of the space in the dermis of the skin, has a strong contraction ability and thus maintains the firmness and elasticity of the skin. Elastin and collagen coexist to give the tissue elastic fibers and resistance to war. At the same time, the dermis also contains many water-retaining ingredients such as hyaluronic acid and polysaccharides.

[0003] The skin is affected not only by internal aging processes, but also by various external stressors that can lead to significant structural changes that affect not only the skin's appearance but also its various physiological functions. Skin aging is mainly due to changes in the extracellular matrix in the dermis, with different changes occurring in the epidermis and dermis during skin aging. Natural intrinsic aging manifests itself as fine lines, gradual thinning of the skin, loss of adipose tissue, and gradual drying of the skin as a whole. Aging caused by external factors, primarily sunlight, often results in rough, dry skin with the appearance of coarse wrinkles and irregular pigmentation.

[0004] Different anti-aging methods are needed to target different structural changes of the skin during aging. The technical deficiencies of existing anti-aging skin care products include: single anti-aging target, poor penetration of active ingredients, and difficulty in achieving both immediate and long-term anti-wrinkle effects. Summary of the invention

[0005] The purpose of the present invention is to overcome the defects of the above-mentioned prior art and provide a composition with instant firming and long-lasting anti-wrinkle effect and its preparation method and application, which has strong permeability, mildness and clear target of action.

[0006] The object of the present invention can be achieved by the following technical scheme: an anti-aging composition with instant firming and long-lasting anti-wrinkle effects, characterized in that the anti-aging composition comprises collagen, microprotein and encapsulated hyaluronic acid in a mass ratio of (0.00001-0.5): (0.00001-3): (0.01-5).

[0007] Furthermore, the mass ratio of the collagen, microprotein and encapsulated hyaluronic acid is (0.01-0.2):(0.01-3):(1-4).

[0008] Furthermore, the collagen is type III small molecule collagen;

[0009] The microprotein is an arginine / lysine polypeptide;

[0010] The encapsulated hyaluronic acid is microcapsule-encapsulated HA.

[0011] Furthermore, the molecular weight of the type III small molecule collagen is less than or equal to 3KDa, and contains a haploid 483-512 core fragment; the arginine / lysine polypeptide is a commercially available wrinkle eraser cono peptide.

[0012] The present invention also provides a skin care product containing the anti-aging composition, wherein the weight percentage of the anti-aging composition in the skin care product is 0.1-9%.

[0013] Furthermore, the anti-aging skin care products include lotions, creams, masks, freeze-dried powders or skin care water.

[0014] Furthermore, the anti-aging skin care product also contains matrix excipients, and the matrix excipients are selected from one or more of water, emulsifiers, emollients, thickeners, pH regulators, moisturizers, antioxidants, preservatives or fragrances.

[0015] Furthermore, the anti-aging skin care product is a facial mask, comprising the following components in percentage by weight:

[0016] The anti-aging composition is 0.1-9%, the emulsifier is 0.1-3%, the emollient is 0.5-10%, the thickener is 0.05-1%, the moisturizer is 1-10%, the antioxidant is 0.01-0.5%, the preservative is 0.3-1%, the pH regulator is 0.05-1%, the essence is 0.0001-0.2%, and the balance is water.

[0017] Further, the emulsifier is selected from one or more of polyglyceryl-6 distearate, jojoba esters, polyglyceryl-3 beeswax ester, polyglyceryl-4 laurate, polyglyceryl-6 laurate, sodium subtilisin, or hydrogenated lecithin;

[0018] The emollient is selected from one or more of jojoba seed oil, caprylic / capric triglyceride, squalane, avocado butter, meadowfoam seed oil, coconut oil caprylate / caprate or hydrogenated coconut oil glyceride;

[0019] The thickener is selected from one or more of sodium polyacrylate, carbomer, xanthan gum or acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer;

[0020] The moisturizer is selected from one or more of glycerin, butylene glycol, 1,3-propylene glycol, sodium hyaluronate, phytosterols or ceramide;

[0021] The pH regulator is one or more of arginine, tromethamine or sodium hydroxide;

[0022] The antioxidant is selected from one or more of tocopherol (vitamin E), sunflower seed oil or tocopherol acetate;

[0023] The preservative is selected from one or more of 1,2-hexanediol, p-hydroxyacetophenone or phenoxyethanol;

[0024] The fragrance is selected from one or more daily-use fragrances.

[0025] The present invention also provides a method for preparing an anti-aging skin care product with instant firming and long-lasting anti-wrinkle effects, comprising the following steps:

[0026] 1) Add emulsifier, emollient and antioxidant into oil pan, heat to 70-75°C, and stir until all dissolved;

[0027] 2) Add deionized water to the emulsifier, add the thickener under stirring at 20-30 rpm, and after it is evenly dispersed, add the moisturizer ingredients, heat to 70-75°C, and keep the temperature constant for 10-20 minutes;

[0028] 3) Under stirring conditions of 20-30 rpm, the ingredients in the oil pan of step 1) are pumped into the emulsifying pan of step 2), and high-speed homogenization is started at 2500-3500 rpm for 5-15 minutes, and then cooling circulating water is started to stir and cool down;

[0029] 4) When the temperature of the material obtained in step 3) drops to 65-70° C., add a pH regulator and continue stirring to cool down;

[0030] 5) When the temperature of the material obtained in step 4) drops to 40-45° C., add the anti-aging composition, preservative and flavor, and continue stirring to cool down;

[0031] 6) When the temperature of the material obtained in step 5) drops to 35-40° C., the machine is stopped and the material is discharged for random inspection, thereby obtaining a facial mask containing the anti-aging composition.

[0032] Compared with the prior art, the present invention has the following beneficial effects:

[0033] 1. The instant firming and long-lasting anti-wrinkle composition provided by the present invention comprises type III small molecule collagen, microprotein and encapsulated HA. Type III small molecule collagen can be absorbed through the skin and directly replenish type III collagen for the skin; microprotein is an instant wrinkle remover with a dual mechanism of action, targeting voltage-gated NaV1.4 channels and nicotinic acetylcholine receptors at the same time. + The inflow is blocked, acetylcholine is antagonized to its receptor, and the formation of muscle action potential is blocked. It can effectively relax the facial muscles without completely paralyzing the nerves, and instantly and effectively remove the expression lines, but it will not make the expression stiff and unnatural; the encapsulated HA contains high molecular weight hyaluronic acid (1-1.4MDa), which is called The microcapsules are encapsulated with the microencapsulation technology, which can penetrate deep into the epidermis and release hyaluronic acid in a targeted manner to fill wrinkles.

[0034] 2. The composition of the present invention has a clear mechanism of action and can achieve instant firming and long-lasting anti-wrinkle effects from different targets at the same time. Compared with the existing firming and anti-wrinkle ingredients on the market, it has better permeability and more obvious effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 This is a quantitative comparison chart of permeability of experimental groups 1 and 2;

[0036] Figure 2 This is a quantitative comparison chart of permeability of experimental groups 3-4;

[0037] Figure 3 This is a quantitative comparison chart of permeability of experimental groups 5-6;

[0038] Figure 4 This is a rendering of the C-Cube facial mask prepared using Example 5. DETAILED DESCRIPTION

[0039] The present invention is described in detail below with reference to specific embodiments.

[0040] The present invention selects a specific ratio of type III small molecule collagen, microprotein and microcapsule-encapsulated HA to be used in combination in a facial mask product to achieve a synergistic anti-aging effect. The specific description is as follows:

[0041] 1. Collagen

[0042] The collagen of the present invention adopts commercially available type III small molecule collagen, which is an important part of opening up the idea of ​​direct skin care. The core fragment of type III collagen is screened by scientific exhaustive method, 100% of which is homologous to human type III. Type III small molecule collagen with a molecular weight less than or equal to 3KDa is selected, and the type III small molecule collagen has only a haploid 483-512 core fragment, which solves the problem of non-humanized heterologous stimulation and rejection, has many integrin sites, and has both a stable triple helix structure and excellent transdermal effect. It can quickly penetrate into the deep layer of the skin and exert an anti-aging effect.

[0043] 2. Microprotein

[0044] The microprotein of the present invention adopts commercially available arginine / lysine polypeptide, which is an artificially synthesized peptide imitating conotoxin, namely wrinkle-erasing cono peptide. Different from arginine / lysine polypeptides from other sources (such as imitating red scorpion toxin) that achieve muscle relaxation by inhibiting the release of nerve choline, the commercially available wrinkle-erasing cono peptide selected by the present invention can selectively inhibit the sodium ion signal pathway, effectively penetrate into the skin, and help reshape facial contours and relieve wrinkles in a short time.

[0045] 3. Microcapsule-encapsulated HA

[0046] Encapsulated HA contains high molecular weight hyaluronic acid (1-1.4 MDa) and is called The product is encapsulated with patented microencapsulation technology (including patents WO9319735 A1, WO9519707 A1 and WO9518601 A1). The microcapsules can penetrate deep into the epidermis and release hyaluronic acid in a targeted manner to fill wrinkles.

[0047] 4. Synergy

[0048] The present invention combines type III small molecule collagen, microprotein, and encapsulated hyaluronic acid in skin care products to achieve a synergistic anti-aging effect. Collagen can restore skin elasticity, reconstruct collagen fiber scaffolds, and improve skin elasticity; microprotein is an advanced mini growth factor that selectively inhibits the sodium ion signaling pathway and can effectively penetrate the skin to help reshape facial contours and relieve wrinkles in a short period of time; encapsulated HA penetrates into the bottom layer of the skin, and then continuously releases hyaluronic acid in the target area to exert an immediate and long-lasting function. The firming and anti-wrinkle composition formed by the combination of the three can better achieve the effects of instant firming and long-lasting anti-wrinkle from different targets, and can be used as an anti-wrinkle active component. When it is applied to the preparation and use of cosmetics, it has strong permeability, high safety, and good anti-wrinkle effect.

[0049] The following is a detailed description through specific examples. The raw materials and detection methods involved in the present invention are commonly used raw materials and detection methods in the art unless otherwise specified.

[0050] Examples 1-5 and Comparative Examples 1-5

[0051] An anti-aging facial mask with instant firming and long-lasting anti-wrinkle effects, comprising the formula described in Table 1-2 below:

[0052] Table 1 Raw material composition formula of Examples 1-5 (weight percentage %)

[0053]

[0054]

[0055] Table 2 Comparative Examples 1-5 Raw Material Components Formula (Weight Percentage %)

[0056]

[0057]

[0058] (2) According to the dosage of each component of Examples 1-5 and Comparative Examples 1-5 in Table 1-2, an anti-aging mask was prepared by the following method:

[0059] 1) Add emulsifier, emollient and antioxidant into oil pan, heat to 70-75°C, and stir until all dissolved;

[0060] 2) Add deionized water to the emulsifier, add the thickener under stirring at 20-30 rpm, and after it is evenly dispersed, add the moisturizer ingredients, heat to 70-75°C, and keep the temperature constant for 10-20 minutes;

[0061] 3) Under stirring conditions of 20-30 rpm, the ingredients in the oil pan of step 1) are pumped into the emulsifying pan of step 2), and high-speed homogenization is started at 2500-3500 rpm for 5-15 minutes, and then cooling circulating water is started to stir and cool down;

[0062] 4) When the temperature of the material obtained in step 3) drops to 65-70° C., add a pH regulator and continue stirring to cool down;

[0063] 5) When the temperature of the material obtained in step 4) drops to 40-45° C., add the anti-aging composition, preservative and flavor, and continue stirring to cool down;

[0064] 6) When the temperature of the material obtained in step 5 drops to 35-40° C., the machine is stopped and the material is discharged for random inspection, and a facial mask containing the anti-aging composition is obtained.

[0065] Performance testing of the products obtained in the embodiments and comparative examples

[0066] (1) Irritation evaluation test

[0067] The finished products of the facial masks of Examples 1-5 and Control Examples 1-5 were subjected to human skin patch tests according to the "2022 Cosmetic Safety Technical Specifications";

[0068] Test method: 50 suitable subjects were selected, including 30 females and 20 males, and divided into 10 groups, with 5 people in each group. Qualified spot test equipment with an area not exceeding 50mm and a depth of about 1mm was selected. The test sample was placed in the small chamber of the spot tester, and the amount was about 0.020-0.025g. The spot tester with the test sample was applied to the curved side of the subject's forearm with low-allergenic tape, and gently pressed with the palm of the hand to evenly apply it to the skin for 24 hours. Observe the skin reaction according to the standards in Table 3 30 minutes (after the indentation disappears), 24 hours and 48 hours after removing the test sample spot tester, and record the observation results. The results are shown in Table 4.

[0069] Table 3 Skin reaction grading standards for skin occlusive patch test

[0070] grade symbol Identification criteria 0 - Negative reaction: no irritation, no erythema 1 ± Suspected reaction: Mild erythema 2 + Weak positive reaction: erythema 3 ++ Strong positive reaction: erythema, papules, blisters 4 +++ Very strong positive reaction: severe edema, large blisters

[0071] Table 4 Class paste test results

[0072] sample 30min 24h 48h Example 1 Level 0 Level 0 Level 0 Example 2 Level 0 Level 0 Level 0 Example 3 Level 0 Level 0 Level 0 Example 4 Level 0 Level 0 Level 0 Example 5 Level 0 Level 0 Level 0 Comparative Example 1 Level 0 Level 0 Level 0 Comparative Example 2 Level 0 Level 0 Level 0 Comparative Example 3 Level 0 Level 0 Level 0 Comparative Example 4 Level 0 Level 0 Level 0 Comparative Example 5 Level 0 Level 0 Level 0

[0073] It can be seen from the patch results in Table 4 that the compositions of Examples 1-5 and Comparative Examples 1-5 achieved the expected effects, and all were negative reactions. In terms of the most basic safety of cosmetics, Examples 1-5 and Comparative Examples 1-5 all meet the requirements for human safety, and are feasible to a certain extent, meet the basic requirements of cosmetics, and also illustrate the safety of the combination of the components of the composition.

[0074] (2) Transdermal permeability test

[0075] To further verify the penetration effect, experimental groups 1-6 were set up for transdermal absorption tests. Using pig skin as a model, an in vitro skin penetration test was conducted using a Franz diffusion cell to detect the permeability of type III small molecule collagen, microprotein, and encapsulated HA in the composition at various time points, thereby evaluating the skin permeability of each component in the composition. Specifically:

[0076] Experimental group 1: Type III small molecule collagen was dissolved in deionized water to prepare a 0.2% aqueous solution as the test sample;

[0077] Experimental group 2: Collagen (commercially available 164.88 type III macromolecular collagen with 16-fold repeats of the 483-512 core fragment) was dissolved in deionized water to prepare a 0.2% aqueous solution as the test sample;

[0078] Experimental group 3: The microprotein was dissolved in deionized water to prepare a 0.2% aqueous solution as the sample to be tested;

[0079] Experimental group 4: The commercially available red scorpion toxin (arginine / lysine polypeptide, a peptide artificially synthesized by imitating red scorpion toxin, whose mechanism of action is to competitively inhibit the formation of SNARE complexes and reduce the release of acetylcholine (ACh), thereby achieving muscle relaxation) was dissolved in deionized water to prepare a 0.2% aqueous solution as the test sample;

[0080] Experimental group 5: The encapsulated HA was dissolved in deionized water to prepare a 2% aqueous solution as the sample to be tested;

[0081] Experimental group 6: 4D hyaluronic acid was dissolved in deionized water to prepare a 2% aqueous solution as the test sample;

[0082] Table 5 Sample plan for epidermal permeability test

[0083] Group Samples to be tested Dosage Experimental Group 1 Type III small molecule collagen 0. 2g Experimental Group 2 Collagen (164.88) 0.2% aqueous solution 2g Experimental Group 3 Microprotein 0.2% aqueous solution 2g Experimental Group 4 Commercial version of red scorpion toxin (arginine / lysine polypeptide) 0.2% aqueous solution 2g Experimental Group 5 Encapsulated HA 2% aqueous solution 2g Experimental Group 6 4D Hyaluronic Acid 2% Aqueous Solution 2g

[0084] Figure 1 This is a quantitative comparison chart of the permeability of experimental groups 1 and 2. Figure 1 It can be seen that, compared with experimental groups 1-2, the transdermal permeability of the type III small molecule collagen in the composition of the present invention is much better than that of other types of type III collagen on the market; Figure 2 This is a quantitative comparison chart of the permeability of experimental groups 3-4. Figure 2 It can be seen that, compared with experimental groups 3-4, the microprotein in the composition of the present invention is able to penetrate the skin due to its small molecular weight and the ability to fold into a stable 3D structure, and has better permeability than the commercially available red scorpion toxin; Figure 3 This is a quantitative comparison chart of the permeability of experimental groups 5 and 6. Figure 3 It can be seen that compared with experimental groups 5-6, the encapsulated HA has better permeability.

[0085] (3) Human efficacy test

[0086] Test equipment: Antera 3D Skin Analyzer, Pixience C Cube

[0087] Test principle:

[0088] Antera 3D Skin Analyzer uses a camera for image acquisition and is equipped with corresponding software. It can capture any part of the human body, with a shooting area of ​​3136mm 2(56x56mm). Use light-emitting diodes with different wavelengths to illuminate the skin for image acquisition and skin analysis. It can obtain three-dimensional images of the skin through innovative optical methods and mathematical algorithms, and perform skin texture and spectral analysis. It can accurately measure the skin's texture, smoothness, fine lines, wrinkle length, depth, width and other data, and can accurately monitor changes in skin condition at any time.

[0089] Pixience C Cube multifunctional skin imaging system is a lightweight and portable integrated system that performs 3D measurements through photometric stereometry. Instruments such as the French company Pixience's multifunctional skin imaging and analysis system C-Cube provide 2D and 3D spectral analysis data for the epidermis and dermis. Using intelligent positioning and matching technology, it can automatically match two or more images of the same part before and after the use of cosmetics. It can quickly, stably, accurately and reliably measure parameters such as skin texture and wrinkles.

[0090] 1) Analysis of changes in skin roughness over time

[0091] Subjects: 50 subjects, including 30 females and 20 males, were divided into 10 groups, with 5 subjects in each group.

[0092] Test method: A series of tests were conducted on the volunteers using a variety of instruments, and the volunteers were self-evaluated to find that their faces were rough, loose and lacked elasticity, and that there was no obvious redness or scars on the face; under the guidance of the staff, they washed their faces, bound their hair, and sat in a constant temperature and humidity environment for 30 minutes, and after the sitting time, Antera 3D image acquisition was performed (the left cheek was photographed); then the facial masks of Examples 1-5 and Control Examples 1-5 were applied to the faces of the volunteers, and they sat in a constant temperature and humidity environment for 15 minutes; after the sitting time, the facial masks were removed, the face was washed, and they sat in a constant temperature and humidity environment for 30 minutes, and Antera 3D image acquisition was performed (the left cheek was photographed).

[0093] Antera 3D Skin Analyzer can accurately measure the average roughness Ra of the skin through skin texture analysis. The smaller the average roughness Ra of the subject's skin, the better the nourishing effect, the more delicate the skin, and the greater the change rate, which means that the wrinkle area ratio is reduced to a greater extent, and the anti-aging and anti-wrinkle effect is better. Among them, Ra1 represents the roughness value measured for the first time, Ra2 is the roughness value measured for the second time, and the change rate = (Ra2-Ra1) / Ra1. The specific results are shown in the following table (average value of each group of subjects).

[0094] Table 6 Changes in average skin roughness

[0095]

[0096] As can be seen from Table 6, the higher the content of type III small molecule collagen, microprotein and microcapsule-encapsulated HA in Examples 1-5, the greater the Ra change rate;

[0097] Compared with Comparative Examples 1-2, Example 2 shows that the anti-wrinkle effect of using both type III small molecule collagen and microprotein is better than that of using only one of them.

[0098] Compared with Example 2 and Comparative Example 3, the anti-wrinkle performance of Comparative Example 3, which only contains type III small molecule collagen and microprotein but does not contain microcapsule-encapsulated HA, is far inferior to that of Example 2; this proves that the anti-wrinkle effect can be greatly improved after the encapsulated HA works synergistically with the other two components, proving that the three components of the present invention have a synergistic effect.

[0099] The anti-wrinkle compositions of Comparative Examples 4-5 use one of them, and the sum of the amounts used is the same as that of Example 2. It can be seen that the anti-wrinkle effects are far inferior to those of Example 2 and Comparative Examples 1-3.

[0100] Therefore, compared with Comparative Examples 1-5, after the subjects used the facial masks in Examples 1-5, the skin roughness of the subjects was generally lower than that of the other groups, and the above results show that under the test conditions of this test, Examples 1-5 can significantly improve skin roughness and achieve immediate anti-wrinkle effect.

[0101] 2) Changes in the proportion of wrinkle area of ​​subjects over time

[0102] Test method: A series of tests were conducted on volunteers using a variety of instruments, and the self-assessment showed that the face was rough, loose and lacked elasticity, and there was no obvious redness or scars on the face; volunteers who continuously used the masks of Examples 1-5 and Control Examples 1-5 were subjected to C-Cube image acquisition (taking pictures of the left corner of the eye) at different time stages under the guidance of staff.

[0103] C-Cube can quantitatively evaluate the changes in wrinkle indicators, so as to obtain the skin images of each subject between each embodiment and the control example. After the skin images are digitally processed, the skin wrinkle area ratio value can be obtained. The change rate refers to the degree of reduction in the skin wrinkle area ratio. The greater the change rate, the greater the degree of reduction in the wrinkle area ratio, and the better the anti-aging and anti-wrinkle effect. The specific results are as follows:

[0104] Table 7 Average wrinkle area change rate (%)

[0105]

[0106] As shown in Table 7, compared with Comparative Examples 1-5, after the subjects used the facial masks in Examples 1-5, the wrinkle areas of the subjects were generally reduced compared with the other groups, and the above results show that under the test conditions, Examples 1-5 can significantly reduce the wrinkle areas and achieve long-term anti-wrinkle effects. At the same time, by comparing Examples 1-5 with Comparative Examples 1-5, it is found that the composition of the present invention has a dose effect, that is, within the allowable range, as the amount of the composition added increases, the long-term anti-wrinkle effect is more obvious, and the effect of type III small molecule collagen and arginine / lysine polypeptide in the composition is stronger than that of encapsulated HA.

[0107] After the above instrument data processing and analysis, it can be known that compared with comparative examples 1-5, the anti-wrinkle and anti-aging effects on the skin of the subjects after using the products in Examples 1-5 are more obvious, and the products in Examples 1-5 all have both immediate and long-lasting anti-wrinkle and anti-aging dual effects, especially the facial masks prepared in Examples 4 and 5 have better immediate firming and long-lasting anti-wrinkle effects.

[0108] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0109] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. An anti-aging composition with instant firming and long-lasting anti-wrinkle effect, characterized in that: The anti-aging composition comprises collagen, microprotein and encapsulated hyaluronic acid in a mass ratio of (0.00001-0.5):(0.00001-3):(0.01-5).

2. The composition with instant firming and long-lasting anti-wrinkle effect according to claim 1, characterized in that: The mass ratio of the collagen, microprotein and encapsulated hyaluronic acid is (0.01-0.2): (0.01-3): (1-4).

3. The composition with instant firming and long-lasting anti-wrinkle effect according to claim 1, characterized in that: The collagen is type III small molecule collagen; The microprotein is an arginine / lysine polypeptide; The encapsulated hyaluronic acid is microcapsule-encapsulated HA.

4. The composition with instant firming and long-lasting anti-wrinkle effect according to claim 3, characterized in that: The molecular weight of the type III small molecule collagen is less than or equal to 3KDa, and contains a single 483-512 core fragment; the arginine / lysine polypeptide is a commercially available wrinkle eraser cono peptide.

5. A skin care product containing the anti-aging composition according to any one of claims 1 to 4, characterized in that: The weight percentage of the anti-aging composition in the skin care product is 0.1-9%.

6. The anti-aging skin care product with instant firming and long-lasting anti-wrinkle properties according to claim 5, characterized in that: The anti-aging skin care products include lotions, creams, masks, freeze-dried powders or skin care water.

7. The anti-aging skin care product with instant firming and long-lasting anti-wrinkle properties according to claim 5, characterized in that: The anti-aging skin care product further contains matrix auxiliary materials, which are selected from one or more of water, emulsifiers, emollients, thickeners, pH regulators, moisturizers, antioxidants, preservatives or fragrances.

8. The anti-aging skin care product with instant firming and long-lasting anti-wrinkle properties according to claim 6, characterized in that: The anti-aging skin care product is a facial mask, comprising the following components in percentage by weight: The anti-aging composition is 0.1-9%, the emulsifier is 0.1-3%, the emollient is 0.5-10%, the thickener is 0.05-1%, the moisturizer is 1-10%, the antioxidant is 0.01-0.5%, the preservative is 0.3-1%, the pH regulator is 0.05-1%, the essence is 0.0001-0.2%, and the balance is water.

9. The anti-aging skin care product with instant firming and long-lasting anti-wrinkle properties according to claim 8, characterized in that: The emulsifier is selected from one or more of polyglyceryl-6 distearate, jojoba esters, polyglyceryl-3 beeswax ester, polyglyceryl-4 laurate, polyglyceryl-6 laurate, sodium subtilisin, or hydrogenated lecithin; The emollient is selected from one or more of jojoba seed oil, caprylic / capric triglyceride, squalane, avocado butter, meadowfoam seed oil, coconut oil caprylate / caprate or hydrogenated coconut oil glyceride; The thickener is selected from one or more of sodium polyacrylate, carbomer, xanthan gum or acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer; The moisturizer is selected from one or more of glycerin, butylene glycol, 1,3-propylene glycol, sodium hyaluronate, phytosterols or ceramide; The pH regulator is one or more of arginine, tromethamine or sodium hydroxide; The antioxidant is selected from one or more of tocopherol (vitamin E), sunflower seed oil or tocopherol acetate; The preservative is selected from one or more of 1,2-hexanediol, p-hydroxyacetophenone or phenoxyethanol; The fragrance is selected from one or more daily-use fragrances.

10. A method for preparing the anti-aging skin care product with instant firming and long-lasting anti-wrinkle properties as claimed in claim 8, characterized in that: The following steps are involved: 1) Add emulsifier, emollient and antioxidant into oil pan, heat to 70-75°C, and stir until all dissolved; 2) Add deionized water to the emulsifier, add the thickener under stirring at 20-30 rpm, and after it is evenly dispersed, add the moisturizer ingredients, heat to 70-75°C, and keep the temperature constant for 10-20 minutes; 3) Under stirring conditions of 20-30 rpm, the ingredients in the oil pan of step 1) are pumped into the emulsifying pan of step 2), and high-speed homogenization is started at 2500-3500 rpm for 5-15 minutes, and then cooling circulating water is started to stir and cool down; 4) When the temperature of the material obtained in step 3) drops to 65-70° C., add a pH regulator and continue stirring to cool down; 5) When the temperature of the material obtained in step 4) drops to 40-45° C., add the anti-aging composition, preservative and flavor, and continue stirring to cool down; 6) When the temperature of the material obtained in step 5) drops to 35-40° C., the machine is stopped and the material is discharged for random inspection, thereby obtaining a facial mask containing the anti-aging composition.

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