Dressing capable of reducing scars and preparation method thereof

Abstract

The invention discloses a dressing capable of reducing scars and a preparation method thereof. The preparation method specifically comprises the following steps: preparing a polyoxyethylene aqueous solution A; dissolving polyethylene glycol and glycerin in water to prepare a solution, and then adding cyclodextrin to obtain a mixed aqueous solution B; uniformly stirring the polyoxyethylene aqueous solution A and the mixed aqueous solution B in proportion to obtain a solution C; dipping a non-woven fabric in the solution C, drying, and taking the film to obtain a film A; soaking the dried membrane in a tannic acid ethanol / water mixed solution; drying after soaking, and stretching and fumigating and cross-linking after drying to obtain a membrane B; soaking the film B in an absolute ethyl alcohol solution of polyvinylpyrrolidone, and drying to obtain a shrinkable layer; and compounding the viscous substrate, the shrinkable layer, the water absorption layer and the release paper to obtain the dressing capable of reducing scars. According to the dressing capable of reducing the scars, the skin can be shrunk immediately after the dressing makes contact with wound exudate, and the scars are reduced.

Description

Technical Field

[0001] The invention relates to the technical field of biomedicine, and in particular to a dressing capable of reducing scar formation. Background Art

[0002] After surgery, the skin near the wound needs to be sutured and then a dressing should be used to protect the wound. Scars will form during the healing process, affecting the appearance. Common treatment methods to reduce scars include using medical elastic bandages with rolled bands and pulling the wound with ordinary medical tape. However, medical elastic bandages do not have the function of absorbing wound exudate and are more suitable for wounds that are close to healing; ordinary tapes are not sticky and have limited effects. They are not very effective for postoperative wounds or ordinary wounds. Summary of the invention

[0003] The object of the present invention is to provide a dressing capable of reducing scar formation and a preparation method thereof, so as to overcome the deficiencies in the prior art.

[0004] To achieve the above object, the present invention provides the following technical solutions: The present application discloses a method for preparing a dressing capable of reducing scar formation, which specifically comprises the following steps: S1, prepare 2%~4% polyethylene oxide aqueous solution A; S2, dissolving polyethylene glycol and glycerol in water to prepare a solution with a concentration of 2% to 4%, then adding cyclodextrin, mixing and stirring to obtain a mixed aqueous solution B; S3, stirring the polyethylene oxide aqueous solution A of step S1 and the mixed aqueous solution B of step S2 in proportion to obtain a solution C; S4, take a non-woven fabric with a spandex content greater than 10% and immerse it in solution C, and after drying, take out the film to obtain film A; wherein the ratio of the area of ​​the non-woven fabric to the mixed solution C is 1cm 2 : 0.2~2g; S5, taking the dried film in step S4, soaking it in a tannic acid ethanol / water mixed solution; drying it at 40-60°C after soaking, and stretching and fumigating and cross-linking it at a temperature of 40-60°C after drying, to obtain film B S6, soaking the film B in step S5 in an anhydrous ethanol solution of polyvinyl pyrrolidone, and drying at 40° C. to 60° C. to obtain a shrinkable layer; S7. Compounding the adhesive base, the shrinkable layer, the water-absorbing layer and the release paper to obtain the dressing capable of reducing scar formation.

[0005] Preferably, the molecular weight of the polyethylene oxide in step S1 is 500,000-2,000,000; and the molecular weight of the polyethylene glycol in step S2 is 800-2,000.

[0006] Preferably, in step S2, the masses of polyethylene glycol and glycerol are equal; the mass of cyclodextrin is 10 times that of polyethylene oxide.

[0007] Preferably, the mixing and stirring in step S2 is carried out at a temperature of 35-65° C. and for a time of 10-30 min.

[0008] Preferably, in step S3, the ratio of the polyethylene oxide aqueous solution A to the mixed aqueous solution B is 1:3-1:5.

[0009] Preferably, in step S4, the nonwoven fabric is immersed in solution C in a stretched state, wherein the stretching ratio is 2-3; and the drying temperature is 40-60°C.

[0010] Preferably, in step S5, the stretching ratio is 1-2; the cross-linking method is formaldehyde fumigation cross-linking, the time is 1 hour, and the formaldehyde concentration is 4%.

[0011] Preferably, in step S5, the tannic acid concentration is 2-10%, the solution is a 50-70% ethanol aqueous solution, the soaking temperature is room temperature, and the soaking time is 25-35 minutes.

[0012] Preferably, in step S6, the concentration of polyvinyl pyrrolidone is 2% to 4%, the solvent is anhydrous ethanol, the immersion temperature is room temperature, and the immersion time is 25 to 35 minutes.

[0013] The present invention also discloses a dressing capable of reducing scar formation, which is prepared by the preparation method of the dressing capable of reducing scar formation as described above; The dressing shrinks when exposed to water / exudate, and the shrinkage ratio is >70%; The product structure is a sticky substrate, a shrinkable layer D, a water-absorbing layer and a release paper; The dressing can shrink the skin near the wound and reduce the generation of scars.

[0014] Beneficial effects of the present invention: 1. The present invention provides a dressing that can reduce the formation of scars. The dressing can shrink the skin immediately after contacting the wound exudate, thereby reducing the formation of scars. 2. The shrinkable layer of the dressing of the present invention is sticky and can be tightly adhered to the water-absorbing layer and the adhesive layer, thereby preventing the layers from falling off and not shrinking during use; 3. The shrinkable layer of the dressing of the present invention is reinforced with polymer, so that it can shrink simultaneously with the tape, avoiding the situation where it cannot move other parts; 4. The elastic nonwoven fabric of the shrinkable layer of the present invention absorbs water simultaneously with the water-absorbing layer, so that the thickness of the water-absorbing layer can be thinner, and the shrinkage is easier while meeting the water absorption ratio; 5. The presence of tannic acid in the dressing of the present invention makes the product have excellent bactericidal properties.

[0015] The features and advantages of the present invention will be described in detail through embodiments in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 Example 1 contraction schematic diagram; Figure 2 Schematic diagram of product healing rate comparison; Figure 3 is a schematic diagram of sample preparation for bonding strength test; DETAILED DESCRIPTION In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below through the accompanying drawings and embodiments. However, it should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the scope of the present invention. In addition, in the following description, the description of known structures and technologies is omitted to avoid unnecessary confusion of the concept of the present invention.

[0017] Embodiment 1: S1: Dissolve 1 g of polyethylene oxide 500000 in 49 g of water at 60°C to obtain a 2% polyethylene oxide aqueous solution A; S2: Dissolve 1.5g PEG800 and 1.5g glycerol in 147g water to obtain a 2% solution. Dissolve 10g cyclodextrin in the above solution at 60°C and stir for 30min to obtain a mixed aqueous solution B; S3: Take 10g of polyethylene oxide aqueous solution A and 30g of mixed aqueous solution B and mix them evenly to obtain solution C; S4: Take a non-woven fabric with a spandex content of 11% and stretch it twice (using a tensile testing machine to stretch it, with an area of ​​10cm 2 ) Add 2g of mixed solution C and spread evenly, and dry at 40℃; obtain film A S5: Take 2g of tannic acid and dissolve it in 98g of 50% ethanol / water solution. Take the dried film A in step S4, soak it in the solution for 30min and then dry it at 40℃. Stretch the dried film 1 times at 40℃ (stretched using a tensile testing machine) and then fumigate it in 4% formaldehyde solution for 1h; obtain film B; S6: Soak the film B after step S5 in anhydrous ethanol solution of 2% polyvinyl pyrrolidone for 30 minutes and dry at 40°C to obtain a shrinkable layer. S7: sequentially compounding the adhesive substrate, the shrinkable layer, the water-absorbing layer and the release paper to obtain a final product; The sticky base is made of adhesive tape, and the absorbent layer is ordinary absorbent cotton.

[0018] Stick the product to wet skin and observe the contraction state ( Figure 1 ); Embodiment 2: S1: Dissolve 2 g of polyethylene oxide 2000000 in 48 g of water at 60°C to obtain a 4% polyethylene oxide aqueous solution A; S2: Dissolve 3g PEG 2000 and 3g glycerol in 144g water to obtain a 4% solution. Dissolve 20g cyclodextrin in the above solution at 60°C and stir for 30min to obtain a mixed aqueous solution B; S3: Take 10g of solution A and 50g of solution B and mix them evenly to obtain solution C; S4: Take a non-woven fabric with a spandex content of 11% and stretch it 3 times (using a tensile testing machine to stretch it, with an area of ​​10cm 2 ) Add 20g of mixed solution C and spread evenly, and dry at 60℃ to obtain film A S5: Dissolve 10g of tannic acid in 90g of 75% ethanol / water solution. Take the dried film A in step S4, soak it in the solution for 30min and then dry it at 60℃. Stretch the dried film 2 times at 60℃ (stretched using a tensile testing machine) and then fumigate it in 4% formaldehyde solution for 1h to obtain film B. S6: Soak the film after step S5 in anhydrous ethanol solution of 4% polyvinyl pyrrolidone for 30 minutes and dry at 60°C to obtain a shrinkable layer. S7: sequentially compounding the adhesive substrate, the shrinkable layer, the water-absorbing layer and the release paper to obtain a final product; Embodiment 3: S1: Dissolve 1.5 g of polyethylene oxide 1000000 in 48.5 g of water at 60°C to obtain a 3% polyethylene oxide aqueous solution A; S2: Dissolve 2.25g PEG 1000 and 2.25g glycerol in 145.5g water to obtain a 3% solution. Dissolve 15g cyclodextrin in the above solution at 60°C and stir for 30min to obtain a mixed aqueous solution B; S3: Take 10g of polyethylene oxide solution A and 40g of the mixed aqueous solution and mix them evenly to obtain solution C; S4: Take a non-woven fabric with a spandex content of 11% and stretch it 2.5 times (stretched using a tensile testing machine with an area of ​​10cm 2 ) Add 10g of mixed solution C and spread evenly, and dry at 50℃; obtain film A S5: Dissolve 6g of tannic acid in 94g of 65% ethanol / water solution. Take the dried film A in step S4, soak it in the solution for 30min and then dry it at 50℃. Stretch the dried film 1.5 times at 50℃ (stretched using a tensile testing machine) and fumigate it in 4% formaldehyde solution for 1h to obtain film B. S6: soaking the film B after step S5 in a 3% polyvinyl pyrrolidone anhydrous ethanol solution for 30 minutes and drying at 60° C. to obtain a shrinkable layer; S7: sequentially compounding the adhesive substrate, the shrinkable layer, the water-absorbing layer and the release paper to obtain a final product; Comparative Example 1: The difference between this comparative example and Example 1 is that: Step S1 is to dissolve 0.5 g of polyethylene oxide 500000 in 49.5 g of water at 60° C. to obtain a 1% polyethylene oxide aqueous solution A; Comparative Example 2: The difference between this comparative example and Example 1 is that: Step S1 is to dissolve 2.5 g of polyethylene oxide 500000 in 47.5 g of water at 60° C. to obtain a 5% polyethylene oxide aqueous solution A; Comparative Example 3: The difference between this comparative example and Example 1 is that: Step S1 is to dissolve 1 g of polyethylene oxide 100000 in 49 g of water at 60° C. to obtain a 2% polyethylene oxide aqueous solution A; Comparative Example 4: The difference between this comparative example and Example 1 is that: Step S1 is to dissolve 1 g of polyethylene oxide 3000000 in 49 g of water at 60° C. to obtain a 2% polyethylene oxide aqueous solution A; Comparative Example 5: The difference between this comparative example and Example 1 is that: Step S2 is to dissolve 0.75 g of PEG 2000 and 0.75 g of glycerol in 148.5 g of water to obtain a 1% solution, dissolve 20 g of cyclodextrin in the above solution at 60° C., and stir for 30 min to obtain a mixed aqueous solution B; Comparative Example 6: The difference between this comparative example and Example 1 is that: Step S2 is to take 3.75g PEG 2000 and 3.75g glycerol and dissolve them in 142.5g water to obtain a 5% solution, take 20g cyclodextrin and dissolve it in the above solution at 60°C, and stir for 30min to obtain a mixed aqueous solution B; Comparative Example 7: The difference between this comparative example and Example 1 is that: Step S2 is to take 1.5g PEG 200 and 1.5g glycerol and dissolve them in 147g water to obtain a 2% solution, take 10g cyclodextrin and dissolve it in the above solution at 60°C, and stir for 30min to obtain a mixed aqueous solution B; Comparative Example 8: The difference between this comparative example and Example 1 is that: Step S3 is to take 20g of polyethylene oxide aqueous solution A and 20g of mixed aqueous solution B and mix them evenly to obtain solution C; Comparative Example 9: The difference between this comparative example and Example 1 is that: Step S3 is to take 5g of polyethylene oxide aqueous solution A and 35g of mixed aqueous solution B and mix them evenly to obtain solution C; Comparative Example 10: The difference between this comparative example and Example 1 is that: Step S4 is to take a non-woven fabric with a spandex content of 11% and stretch it by 1 times (area 10cm 2 ) Add 2g of mixed solution C and spread evenly, and dry at 40℃; Comparative Example 11: The difference between this comparative example and Example 1 is that: Step S4 is to take a non-woven fabric with a spandex content of 11% and stretch it 5 times (area 10cm 2 ) Add 2 g of mixed solution C and spread evenly, and dry at 40°C to obtain film A; Comparative Example 12: The difference between this comparative example and Example 1 is that: Step S4 is to take a non-woven fabric with a spandex content of 11% and stretch it 5 times (area 10cm 2 ) Add 1 g of mixed solution C and spread evenly, and dry at 40°C to obtain film A; Comparative Example 13: The difference between this comparative example and Example 1 is that: Step S4 is to take a non-woven fabric with a spandex content of 11% and stretch it 5 times (area 10cm 2 ) add 25g of mixed solution C and spread evenly, and dry at 40°C to obtain film A; Comparative Example 14: The difference between this comparative example and Example 1 is that: Step S5 is to dissolve 2 g of tannic acid in 98 g of 50% ethanol / water solution, soak the dried film A in the solution for 30 min and then dry it at 40° C., stretch the dried film 0.5 times at 40° C. and then fumigate it in 4% formaldehyde solution for 1 h to obtain film B; Comparative Example 15: The difference between this comparative example and Example 1 is that: Step S5 is to dissolve 2 g of tannic acid in 98 g of 50% ethanol / water solution, soak the dried film A in the solution for 30 min and then dry it at 40° C., stretch the dried film 3 times at 40° C. and then fumigate it in 4% formaldehyde solution for 1 h to obtain film B; Comparative Example 16: The difference between this comparative example and Example 1 is that: Step S5 is to dissolve 1 g of tannic acid in 99 g of 50% ethanol / water solution, soak the dried film in step S4 for 30 min and then dry it at 40° C., stretch the dried film by 1 times at 40° C. and then fumigate it in 4% formaldehyde solution for 1 h to obtain film B; Comparative Example 17: The difference between this comparative example and Example 1 is that: Step S5 is to dissolve 15 g of tannic acid in 85 g of 50% ethanol / water solution, soak the dried film A in the solution for 30 min and then dry it at 40° C., stretch the dried film by 1 times at 40° C. and then fumigate it in 4% formaldehyde solution for 1 h to obtain film B; Comparative Example 18: The difference between this comparative example and Example 1 is that: Step S5 is to dissolve 2 g of tannic acid in 98 g of 40% ethanol / water solution, soak the dried film A in the solution for 30 min and then dry it at 40° C., stretch the dried film by 1 times at 40° C. and then fumigate it in 4% formaldehyde solution for 1 h to obtain film B; Comparative Example 19: The difference between this comparative example and Example 1 is that: Step S5 is to dissolve 2 g of tannic acid in 98 g of 80% ethanol / water solution, soak the dried film A in the solution for 30 min and then dry it at 40° C., stretch the dried film by 1 times at 40° C. and then fumigate it in 4% formaldehyde solution for 1 h to obtain film B; Comparative Example 20: The difference between this comparative example and Example 1 is that: Step S6 is to soak the membrane B after Step S5 in an anhydrous ethanol solution of 1% polyvinyl pyrrolidone for 30 minutes and dry it at 40°C; Comparative Example 21: The difference between this comparative example and Example 1 is that: Step S5 is to dissolve 2 g of tannic acid in 98 g of 50% ethanol / water solution, soak the dried film A in the solution for 30 min, and then dry it at 40° C. The dried film is stretched by 1 times at 40° C. (stretched using a tensile testing machine), to obtain film B; Product performance test: 1. Tensile strength / elongation at break test: The overall shrinkage performance of the product is determined by the shrinkable layer, so only its tensile strength and rate are tested.

[0019] Take the film from step S6 and cut it into a 50 mm × 10 mm strip, and measure the strip thickness D (in mm); fix the two ends of the strip on the fixture of the universal material testing machine, with a distance of 20 mm between the fixtures. Then stretch the strip at a rate of 50 mm / min until the strip breaks, and record the maximum force F (in N) during this process. The tensile strength T is calculated as follows: Where: W is the width of the specimen, 10 mm.

[0020] 2. Shrinkage strength / shrinkage ratio test: The overall shrinkage performance of the product is determined by the shrinkable layer, so only its shrinkage strength and ratio are tested.

[0021] Take the film from step S6 and cut it into a 50 mm × 10 mm strip, and measure the strip thickness D (in mm); fix the two ends of the strip on the fixture of the universal material testing machine, with a distance of 20 mm between the fixtures. Then spray water on the strip, and record the data and length of the retraction of the testing machine.

[0022] The data calculation is consistent with the tensile strength, and the shrinkage rate is the percentage of length change before and after shrinkage.

[0023] 3. Adhesion strength test: Viscosity determines whether the product will fall off when it encounters liquid, so the adhesion strength between the shrinkable layer and the adhesive base is tested. Figure 3 Prepare the sample, the overlapping part has a length and width of 1cm*1cm. Use a tensile testing machine to clamp the base layer and the shrinkable layer of the sample, and record the maximum value (N) at a constant rate of stretching.

[0024] 4. Weight loss rate: The longest usage time of the dressing is 24 hours, so the product limit requirement is to maintain 24-hour contraction force and controllable weight loss.

[0025] Take 2.0 g of the membrane on the surface of step S6, soak it in PBS buffer at 37° C. for 24 h, and record the percentage of weight change before and after as the weight loss rate.

[0026] 5. Scar reduction: Anesthetize the rats with 10% chloral hydrate (0.3 ml / kg), shave the hair on the back of the rats with a razor, disinfect with iodine, draw a 1 cm circle with sterile dye, cut off the full thickness skin within the circle with ophthalmic scissors, and apply the dressings of the experimental group and the control group to the skin. The experimental group is the dressing prepared in Example 1, and the control group is the commercially available sterile dressing. The dressing is changed every 8 hours. The wound healing is measured on days 0, 3, 7, 10 and 14, the healing rate is calculated, and the scar formation is observed (see Figure 2 ).

[0027] The experimental results of Example 1 and Comparative Example 1 show that when the concentration of polyethylene oxide is low, the film formed on the surface of step S6 is easily soluble in water; The results of Comparative Example 2 show that polyethylene oxide is extremely difficult to dissolve in water, and it is difficult to obtain a 5% aqueous solution; The results of Comparative Example 3 show that low molecular weight polyethylene oxide is easily soluble in water after film formation and cannot be used; The results of Comparative Example 4 show that high molecular weight polyethylene oxide is difficult to dissolve in water. If it needs to be dissolved, it needs to be dissolved at a very low concentration and then evaporated at a high temperature; The results of Comparative Example 5 show that when the concentration of plasticizer is low, the film is brittle; the results of Comparative Example 6 show that when there is too much plasticizer, there will be excess precipitation on the surface of the product, which is oily and affects the appearance; The results of Comparative Example 7 show that the speed-increasing effect of low molecular weight PEG is limited; The results of comparative example 8 show that the low ratio of mixed solute between solutions is low, the film is thin and easily soluble in water; The results of Comparative Example 9 show that the performance of the product obtained after high-ratio mixing between solutions is consistent with that of the embodiment. Considering the cost, this parameter is not selected; The results of Comparative Examples 10 and 11 show that the stretch ratio of the stretch fabric has a certain influence on the shrinkage of the finished product; the lower the ratio, the smaller the shrinkage force; but the shrinkage of the product mainly depends on the surface film (Comparative Examples 14 and 15); The results of Comparative Examples 12 and 13 show that if the film-laying ratio is too low, the surface cannot form a film; if it is too thick, it will break when stretched; The results of Comparative Examples 16 and 17 show that the concentration of tannic acid affects the viscosity of the product. The performance does not change qualitatively when the concentration is higher than the claimed range, so this parameter is not considered. In comparative example 18, water accounted for too much, and the uncrosslinked membrane was dissolved in water; in comparative example 19, water accounted for too much, and tannic acid could not be used; The results of Comparative Example 20 show that polyvinyl pyrrolidone has the effect of enhancing mechanical properties at a certain ratio; The results of Comparative Example 21 show that the product is not cross-linked and is easily soluble in water; By comparing the healing rates of mice in the examples with those of commercially available sterile dressings, it can be seen that this product has a healing-promoting effect.

[0028] Unless otherwise specified, all solutions are aqueous solutions. This patent invents a dressing that absorbs wound exudate through chemical action and then automatically shrinks to reduce scars. It includes a sticky base, a shrinkable layer, a water-absorbing layer, and a release paper layer. After the product is adhered to the skin surface, the product absorbs the exudate to maintain a moist environment while the liquid enters the shrinkable layer, causing the product to shrink as a whole to promote wound healing and reduce scar formation.

[0029] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the protection scope of the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A method for preparing a dressing capable of reducing scar formation, characterized in that: The specific steps include: S1, prepare 2%~4% polyethylene oxide aqueous solution A; S2, dissolving polyethylene glycol and glycerol in water to prepare a solution with a concentration of 2% to 4%, then adding cyclodextrin, mixing and stirring to obtain a mixed aqueous solution B; S3, stirring the polyethylene oxide aqueous solution A of step S1 and the mixed aqueous solution B of step S2 in proportion to obtain a solution C; S4, taking a non-woven fabric with a spandex content greater than 10% and immersing it in solution C, and taking a film after drying to obtain film A; The ratio of the area of ​​the nonwoven fabric to the mixed solution C is 1 cm 2 : 0.2~2g; S5, taking the dried film in step S4, soaking it in a tannic acid ethanol / water mixed solution; drying it at 40-60°C after soaking, and stretching and fumigating and cross-linking it at a temperature of 40-60°C after drying, to obtain film B S6, soaking the film B in step S5 in an anhydrous ethanol solution of polyvinyl pyrrolidone, and drying at 40° C. to 60° C. to obtain a shrinkable layer; S7. Compounding the adhesive base, the shrinkable layer, the water-absorbing layer and the release paper to obtain the dressing capable of reducing scar formation.

2. The method for preparing a dressing capable of reducing scar formation as claimed in claim 1, characterized in that: The molecular weight of the polyethylene oxide in step S1 is 500,000-2,000,000; the molecular weight of the polyethylene glycol in step S2 is 800-2,000.

3. The method for preparing a dressing capable of reducing scar formation according to claim 1, characterized in that: In step S2, the masses of polyethylene glycol and glycerol are equal; the mass of cyclodextrin is 10 times that of polyethylene oxide.

4. The method for preparing a dressing capable of reducing scar formation according to claim 1, characterized in that: The mixing and stirring in step S2 is performed at a temperature of 35-65° C. and for a time of 10-30 min.

5. The method for preparing a dressing capable of reducing scar formation according to claim 1, characterized in that: In step S3, the ratio of the polyethylene oxide aqueous solution A to the mixed aqueous solution B is 1:3 to 1:

5.

6. The method for preparing a dressing capable of reducing scar formation according to claim 1, characterized in that: In step S4, the nonwoven fabric is immersed in solution C in a stretched state, wherein the stretching ratio is 2-3; and the drying temperature is 40-60°C.

7. The method for preparing a dressing capable of reducing scar formation according to claim 1, characterized in that: In step S5, the stretching ratio is 1-2; the cross-linking method is formaldehyde fumigation cross-linking, the time is 1 hour, and the formaldehyde concentration is 4%.

8. The method for preparing a dressing capable of reducing scar formation according to claim 1, characterized in that: In step S5, the concentration of tannic acid is 2-10%, the solution is 50-70% ethanol aqueous solution, the soaking temperature is room temperature, and the soaking time is 25-35 minutes.

9. The method for preparing a dressing capable of reducing scar formation according to claim 1, characterized in that: In step S6, the concentration of polyvinyl pyrrolidone is 2% to 4%, the solvent is anhydrous ethanol, the immersion temperature is room temperature, and the immersion time is 25 to 35 minutes.

10. A dressing capable of reducing scar formation, characterized in that: The dressing is prepared by the method for preparing a dressing capable of reducing scar formation as described in any one of claims 1 to 9.

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