Nicotine-ion exchange resin compound, preparation method and application

Abstract

The invention discloses a nicotine-ion exchange resin compound, a preparation method and application. The preparation method of the nicotine-ion exchange resin compound comprises the following steps: dissolving nicotine in an auxiliary solvent to obtain a first mixed solution; adding acidic ion exchange resin into the first mixed solution, and stirring to obtain a second mixed solution; and filtering the auxiliary solvent in the second mixed solution to obtain a wet material, and carrying out vacuum drying on the wet material to obtain the powdery nicotine-ion exchange resin compound. According to the technical scheme, the preparation process of the powdery nicotine-ion exchange resin compound is simple, and the cost is low. The ion exchange resin serving as a nicotine carrier has the effects of slow release, taste masking, nicotine stability enhancing and nicotine dissolution promoting, so that in the buccal cigarette application, the buccal cigarette can be comfortable in mouth and good in taste, nicotine can be uniformly and slowly released in a human body for a long time, and long-acting and mild physiological satisfaction is provided for consumers.

Description

Technical Field

[0001] The present application relates to the technical field of nicotine product production, and in particular to a nicotine-ion exchange resin complex, a preparation method and an application thereof. Background Art

[0002] Currently, nicotine used in new nicotine products mostly exists in the form of nicotine extracts, free nicotine, liquid nicotine salts, etc. When using such products, nicotine is released too quickly and too violently, which will cause certain oral and gastrointestinal irritation and cause physical discomfort. The problem is that the initial force of the cigarette is too strong and the later force is too weak, and the smoke taste fades quickly during the entire mouth-holding process.

[0003] In order to release nicotine evenly, slowly and persistently in the oral cavity, provide consumers with long-lasting and peaceful physiological satisfaction, and effectively reduce irritation to the digestive tract, solid nicotine salts need to be developed. In order to achieve the effective and slow release of nicotine in oral non-tobacco products, most researchers currently use tobacco extracts in the form of simple microencapsulation to effectively control nicotine. This method has a complex process and a low yield. Summary of the invention

[0004] The present application provides a nicotine-ion exchange resin complex, a preparation method and an application thereof, aiming to solve the problem of complex preparation process and low yield of solid nicotine salt in the prior art.

[0005] To achieve the above-mentioned purpose, the present application proposes a method for preparing a nicotine-ion exchange resin complex. The preparation method comprises the following steps:

[0006] dissolving nicotine in an auxiliary solvent to obtain a first mixed solution;

[0007] adding an acidic ion exchange resin to the first mixed solution, and stirring to obtain a second mixed solution;

[0008] The auxiliary solvent in the second mixed solution is filtered to obtain a wet material, and the wet material is vacuum dried to obtain a powdery nicotine-ion exchange resin complex.

[0009] In some embodiments, the added mass ratio of the nicotine to the auxiliary solvent is 1:15-160.

[0010] In some embodiments, the auxiliary solvent is at least one of ethanol, water and ethyl acetate.

[0011] In some embodiments, the added mass ratio of the nicotine to the acidic ion exchange resin is 1:0.5-5.

[0012] In some embodiments, the acidic ion exchange resin includes at least one of a strongly acidic cation exchange resin and a weakly acidic cation exchange resin;

[0013] The strong acid cation exchange resin includes styrene strong acid ion exchange resin and macroporous strong acid ion exchange resin; the weak acid cation exchange resin includes isobutyric acid ion exchange resin, acrylic acid ion exchange resin and 724 weak acid ion exchange resin.

[0014] In some embodiments, the stirring speed after adding the acidic ion exchange resin to the first mixed solution is 250 to 350 r / min, and the stirring time is 1 to 12 hours.

[0015] In some embodiments, the stirring time is 1 to 5 hours.

[0016] In some embodiments, the vacuum drying has a drying temperature of 40 to 50° C. and a drying time of 2.5 to 4 hours.

[0017] The present application also provides a nicotine-ion exchange resin complex, which is prepared by the preparation method of the nicotine-ion exchange resin complex as described above.

[0018] The present application also proposes an application of the above-mentioned nicotine-ion exchange resin complex in oral cigarettes.

[0019] The technical scheme of the present application proposes a nicotine-ion exchange resin complex, a preparation method and an application. The preparation method comprises: dissolving nicotine in an auxiliary solvent to obtain a first mixed solution; adding an acidic ion exchange resin to the first mixed solution, stirring to obtain a second mixed solution; filtering the auxiliary solvent in the second mixed solution to obtain a wet material, and vacuum drying the wet material to obtain a powdered nicotine-ion exchange resin complex. The technical scheme of the present application adopts the process steps of dissolving nicotine-adding an acidic ion exchange resin and stirring-filtering the auxiliary solvent and drying to obtain a powdered nicotine-ion exchange resin complex, which has a simple process and economical cost. In the complex, the ion exchange resin acts as a carrier of nicotine, has the functions of sustained release, taste masking, enhancing the stability of nicotine and promoting the dissolution of nicotine. Therefore, in the further application of oral cigarettes, the oral cigarettes can be made comfortable to the mouth and taste good, and nicotine can be released evenly, slowly and persistently in the human body, providing consumers with a long-lasting and peaceful physiological satisfaction. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the prior art descriptions are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative work, among which:

[0021] Figure 1 This is a schematic diagram of the preparation process of a nicotine-ion exchange resin complex according to an embodiment of the present application;

[0022] Figure 2 This is a comparison curve diagram of the in vitro release effect of the nicotine-ion exchange resin complex according to an embodiment of the present application. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0024] See also Figure 1 As shown, the present application proposes a method for preparing a nicotine-ion exchange resin complex. The preparation method comprises:

[0025] Step S10, dissolving nicotine in an auxiliary solvent to obtain a first mixed solution.

[0026] This step aims to dissolve nicotine in the auxiliary solvent to ensure that nicotine is dispersed in the solution, thereby facilitating the subsequent combination with the ion exchange resin.

[0027] In the process of preparing the first mixed solution, the dissolution of nicotine can be promoted by stirring or heating. Alternatively, the nicotine raw material can be properly processed, such as crushing, grinding, etc., to increase the contact area between nicotine and the auxiliary solvent and improve the dissolution rate.

[0028] In the preparation of the first mixed solution, the mass ratio of nicotine to the auxiliary solvent is 1:15 to 160. In this way, the relative addition amounts of nicotine and the auxiliary solvent can be adjusted as needed to prepare first mixed solutions with different nicotine concentrations.

[0029] Furthermore, the auxiliary solvent is at least one of ethanol, water, and ethyl acetate. Ethanol, water, and ethyl acetate are all common solvents with low prices and are easy to obtain and store. This can reduce the complexity of the operation during the dissolution of nicotine and save process raw materials and preparation costs.

[0030] Step S20, adding an acidic ion exchange resin into the first mixed solution, and stirring to obtain a second mixed solution.

[0031] This step aims to make the acidic ion exchange resin fully react with the nicotine in the first mixed solution, so that the nicotine is adsorbed onto the acidic ion exchange resin through the action of the ion exchange resin.

[0032] Furthermore, the added mass ratio of nicotine to acidic ion exchange resin is 1:0.5-5. That is, one mass of nicotine can correspond to 0.5-5 mass of acidic ion exchange resin to efficiently adsorb nicotine. Among them, the acidic ion exchange resin includes at least one of a strong acidic cation exchange resin and a weak acidic cation exchange resin; further, the strong acidic cation exchange resin includes styrene strong acidic ion exchange resin and macroporous strong acidic ion exchange resin, and the weak acidic cation exchange resin includes isobutyric acid ion exchange resin, acrylic acid ion exchange resin and 724 weak acidic ion exchange resin.

[0033] After the acidic ion exchange resin is added to the first mixed solution, stirring can be performed to ensure sufficient mixing and contact between nicotine and the ion exchange resin, thereby improving the reaction efficiency. In some embodiments, the stirring speed is 250 to 350 r / min, and the stirring time is 1 to 12 hours. Preferably, the stirring time is 1 to 5 hours.

[0034] Step S30, filtering the auxiliary solvent in the second mixed solution to obtain a wet material, and vacuum drying the wet material to obtain a powdery nicotine-ion exchange resin complex.

[0035] It can be understood that after step S20, the second mixed solution contains nicotine ion exchange resin complex and auxiliary solvent, which are filtered and dried in sequence to completely remove the auxiliary solvent and water, leaving a powdery nicotine-ion exchange resin complex product.

[0036] Among them, the auxiliary solvent in the second mixed solution can be filtered by vacuum filtration. Exemplarily, the second mixed solution is poured into the filtering device, and the switch of the vacuum device is turned on to form a negative pressure inside the filtering device, thereby accelerating the filtration speed of the solution, and finally obtaining the filtrate and the wet material respectively. The vacuum drying operation of the wet material can be carried out in a vacuum drying oven. In some embodiments, the drying temperature of the vacuum drying is 40 to 50°C, and the drying time is 2.5 to 4 hours, so as to dry for a period of time within a suitable temperature range to ensure the adequacy of the drying.

[0037] At this point, the nicotine-ion exchange resin complex is prepared through the above preparation steps. It can be understood that the acidic ion exchange resin is a network skeleton structure polymer with a long molecular main chain and cross-linked cross chains, which can exchange ions in the solution. Among them, the ion exchange equilibrium reaction between the acidic ion exchange resin and the basic nicotine is as follows:

[0038] R-SO3H+B-NH2←→R-SO3+H3N-B

[0039] In the formula, R-SO3H represents acidic ion exchange resin, and B-NH2 represents alkaline nicotine. This formula is a reversible reaction, the forward direction represents nicotine loading, and the reverse direction represents nicotine release. After nicotine is loaded on the resin, it is called nicotine-ion exchange resin complex.

[0040] Therefore, based on the reversibility of ion exchange, when the complex enters the oral cavity, it will undergo a reverse ion exchange reaction with the physiological ions in the oral cavity, thereby continuously and slowly releasing alkaline nicotine. At the same time, based on the acidic ion exchange resin as a carrier, the complex is insensitive to the alkaline nicotine in the saliva with a pH value of 6.8, achieving a taste masking effect; and after the complex is formed, the alkaline nicotine is dispersed in the polymer skeleton and exists in an amorphous form, thereby further enhancing the stability of nicotine and promoting the dissolution of nicotine.

[0041] The present application proposes the following specific embodiments of nicotine-ion exchange resin complex:

[0042] Example 1

[0043] 1 g of nicotine was dissolved in 30 mL of anhydrous ethanol to obtain a first mixed solution, 0.5 g of weakly acidic ion exchange resin was added to the first mixed solution, and the mixture was stirred at 300 r / min for 1 h to obtain a second mixed solution, the auxiliary solvent in the second mixed solution was filtered out to obtain a wet material, and the wet material was placed in a vacuum oven and dried at 45° C. for 3 h to obtain a powdered nicotine-ion exchange resin complex.

[0044] Example 2

[0045] 1 g of nicotine was dissolved in 30 mL of anhydrous ethanol to obtain a first mixed solution, 3 g of weakly acidic ion exchange resin was added to the first mixed solution, and the mixture was stirred at 300 r / min for 1 h to obtain a second mixed solution, the auxiliary solvent in the second mixed solution was filtered out to obtain a wet material, and the wet material was placed in a vacuum oven and dried at 45° C. for 3 h to obtain a powdered nicotine-ion exchange resin complex.

[0046] Example 3

[0047] 1 g of nicotine was dissolved in 30 mL of anhydrous ethanol to obtain a first mixed solution, 5 g of weakly acidic ion exchange resin was added to the first mixed solution, and the mixture was stirred at 300 r / min for 1 h to obtain a second mixed solution, the auxiliary solvent in the second mixed solution was filtered out to obtain a wet material, and the wet material was placed in a vacuum oven and dried at 45° C. for 3 h to obtain a powdered nicotine-ion exchange resin complex.

[0048] Example 4

[0049] 1 g of nicotine was dissolved in an auxiliary solvent composed of 15 mL of anhydrous ethanol and 15 mL of water to obtain a first mixed solution, 3 g of a weakly acidic ion exchange resin was added to the first mixed solution, and the mixture was stirred at 300 r / min for 1 hour to obtain a second mixed solution, the auxiliary solvent in the second mixed solution was filtered out to obtain a wet material, and the wet material was placed in a vacuum oven and dried at 45° C. for 3 hours to obtain a powdered nicotine-ion exchange resin complex.

[0050] Example 5

[0051] 1 g of nicotine was dissolved in an auxiliary solvent composed of 10 mL of anhydrous ethanol, 10 mL of water and 10 mL of ethyl acetate to obtain a first mixed solution, 3 g of weakly acidic ion exchange resin was added to the first mixed solution, and the mixture was stirred at 300 r / min for 1 hour to obtain a second mixed solution, the auxiliary solvent in the second mixed solution was filtered out to obtain a wet material, and the wet material was placed in a vacuum oven and dried at 45° C. for 3 hours to obtain a powdered nicotine-ion exchange resin complex.

[0052] Example 6

[0053] 1 g of nicotine was dissolved in 90 mL of anhydrous ethanol to obtain a first mixed solution, 3 g of weakly acidic ion exchange resin was added to the first mixed solution, and the mixture was stirred at 300 r / min for 1 h to obtain a second mixed solution, the auxiliary solvent in the second mixed solution was filtered out to obtain a wet material, and the wet material was placed in a vacuum oven and dried at 45° C. for 3 h to obtain a powdered nicotine-ion exchange resin complex.

[0054] Example 7

[0055] 1 g of nicotine was dissolved in 150 mL of anhydrous ethanol to obtain a first mixed solution, 3 g of weakly acidic ion exchange resin was added to the first mixed solution, and the mixture was stirred at 300 r / min for 1 h to obtain a second mixed solution, the auxiliary solvent in the second mixed solution was filtered out to obtain a wet material, and the wet material was placed in a vacuum oven and dried at 45° C. for 3 h to obtain a powdered nicotine-ion exchange resin complex.

[0056] Example 8

[0057] 1 g of nicotine was dissolved in 30 mL of anhydrous ethanol to obtain a first mixed solution, 3 g of a strongly acidic ion exchange resin was added to the first mixed solution, and the mixture was stirred at 300 r / min for 1 h to obtain a second mixed solution, the auxiliary solvent in the second mixed solution was filtered out to obtain a wet material, and the wet material was placed in a vacuum oven and dried at 45° C. for 3 h to obtain a powdered nicotine-ion exchange resin complex.

[0058] Example 9

[0059] 1 g of nicotine was dissolved in 30 mL of anhydrous ethanol to obtain a first mixed solution, 5 g of acidic ion exchange resin (including 2.5 g of strong acidic ion exchange resin and 2.5 g of weak acidic ion exchange resin) was added to the first mixed solution, and the mixture was stirred at 300 r / min for 1 hour to obtain a second mixed solution, the auxiliary solvent in the second mixed solution was filtered out to obtain a wet material, and the wet material was placed in a vacuum oven and dried at 45° C. for 3 hours to obtain a powdered nicotine-ion exchange resin complex.

[0060] Example 10

[0061] 1 g of nicotine was dissolved in 30 mL of anhydrous ethanol to obtain a first mixed solution, 5 g of acidic ion exchange resin (including 4 g of strong acid ion exchange resin and 1 g of weak acid ion exchange resin) was added to the first mixed solution, and the mixture was stirred at 300 r / min for 1 h to obtain a second mixed solution, the auxiliary solvent in the second mixed solution was filtered out to obtain a wet material, and the wet material was placed in a vacuum oven and dried at 45° C. for 3 h to obtain a powdered nicotine-ion exchange resin complex.

[0062] Embodiment 11

[0063] 1 g of nicotine was dissolved in 30 mL of anhydrous ethanol to obtain a first mixed solution, 5 g of acidic ion exchange resin (including 1 g of strong acid ion exchange resin and 4 g of weak acid ion exchange resin) was added to the first mixed solution, and the mixture was stirred at 300 r / min for 1 h to obtain a second mixed solution, the auxiliary solvent in the second mixed solution was filtered out to obtain a wet material, and the wet material was placed in a vacuum oven and dried at 45° C. for 3 h to obtain a powdered nicotine-ion exchange resin complex.

[0064] Example 12

[0065] 1 g of nicotine was dissolved in 30 mL of anhydrous ethanol to obtain a first mixed solution, 1 g of acidic ion exchange resin (including 0.5 g of strong acid ion exchange resin and 0.5 g of weak acid ion exchange resin) was added to the first mixed solution, and the mixture was stirred at 300 r / min for 1 hour to obtain a second mixed solution, the auxiliary solvent in the second mixed solution was filtered out to obtain a wet material, and the wet material was placed in a vacuum oven and dried at 45° C. for 3 hours to obtain a powdered nicotine-ion exchange resin complex.

[0066] Embodiment 13

[0067] 1 g of nicotine was dissolved in 30 mL of anhydrous ethanol to obtain a first mixed solution, 3 g of acidic ion exchange resin (including 1.5 g of strong acid ion exchange resin and 1.5 g of weak acid ion exchange resin) was added to the first mixed solution, and the mixture was stirred at 300 r / min for 1 hour to obtain a second mixed solution, the auxiliary solvent in the second mixed solution was filtered out to obtain a wet material, and the wet material was placed in a vacuum oven and dried at 45° C. for 3 hours to obtain a powdered nicotine-ion exchange resin complex.

[0068] The above embodiments are only some embodiments of the present application, and various parameters can be selected within the scope of protection of the present application to achieve sufficient dissolution of nicotine in the auxiliary solvent, sufficient stirring after the acidic ion exchange resin is added to the first mixed solution, and sufficient drying of the prepared wet material, so as to obtain the final nicotine-ion exchange resin complex.

[0069] The present application further measures the nicotine content and nicotine utilization in the nicotine-ion exchange resin complex prepared in the above embodiment. The determination method includes: placing 30 mg of nicotine-ion exchange resin complex in a flask, adding 10 mL of 1M ammonium hydroxide, then adding 5 mL of 1M acetic acid solution, diluting with water to 25 mL, ultrasonically shaking for 30 minutes, centrifuging at 12000 r / min for 10 minutes, taking 5 mL of supernatant, and determining the nicotine content by HPLC. Then calculate the nicotine utilization rate (E,%) in the equilibrium stage. The formula is:

[0070] E = nicotine content in the resin complex / input amount*100;

[0071] The calculation results of each embodiment are sorted out to obtain the following Table 1.

[0072] Table 1

[0073] Nicotine utilization rate (E,%) Example 1 84.82 Example 2 90.36 Example 3 93.12 Example 4 90.34 Example 5 91.94 Example 6 91.45 Example 7 91.80 Example 8 93.71 Example 9 95.25 Example 10 96.48 Embodiment 11 92.45 Example 12 85.61 Embodiment 13 91.77

[0074] It can be seen from Table 1 that in the nicotine-ion exchange resin complex prepared by the preparation method proposed in the present application, the nicotine utilization rate is between 84.82% and 96.48%, thereby reducing the residual rate of nicotine and obtaining a better effect.

[0075] The present application further tests the in vitro release effect of the nicotine-ion exchange resin complex prepared by the preparation method of the present application.

[0076] For example, 10 mg of each of the nicotine-ion exchange resin complex, tartrate and nicotine benzoate prepared in Example 1 are taken in equal amounts, the above different nicotine salt powders are placed in a test tube, 10 mL of a 9 mg / mL NaCL aqueous solution is added and the temperature is raised to 37°C, shaken, and the filtrate is filtered. 1 mL of the above filtrate is placed in a 25 mL volumetric flask, and then diluted to 25 mL with a 0.1 mol / L HCl solution. The release rate of nicotine at different time lengths is measured using a UV spectrophotometer, and the following is obtained: Figure 2 The curve graph described.

[0077] from Figure 2 As shown, the nicotine-ion exchange resin complex prepared in the present application has the longest and most gentle release rate, while nicotine tartrate and nicotine benzoate are relatively fast. When the nicotine release reaches 80%, the nicotine released from the nicotine-ion exchange resin will not cause excessive irritation to the human body, such as dizziness and gastrointestinal discomfort caused by excessive strength in the early stage of oral administration.

[0078] The present application also proposes the application of the prepared nicotine-ion exchange resin complex in oral cigarettes, including the preparation of oral cigarette pouches based on the nicotine-ion exchange resin complex. In one example, the preparation method of the oral cigarette pouch is: the prepared nicotine-ion exchange resin complex is mixed with microcrystalline cellulose, cellulose derivatives, propylene glycol, glycerol, sodium chloride, sodium carbonate, aspartame and glucose at a stirring speed of 300r / min, sealed and refrigerated at 5°C for 24h, sterilized by ultraviolet for 3 hours, and then packaged to obtain the finished product. Among them, the mass proportions of nicotine-ion exchange resin complex and microcrystalline cellulose, cellulose derivatives, propylene glycol, glycerol, sodium chloride, sodium carbonate, aspartame and glucose are 2%, 63%, 8%, 4%, 4%, 5%, 5%, 3% and 6% respectively, and finally a nicotine oral cigarette pouch containing 12mg / g is obtained. Among them, based on the nicotine-ion exchange resin complex prepared in Examples 1-13 of the present application, the corresponding oral tobacco pouch prepared in Examples 1-13 can be obtained.

[0079] The oral tobacco pouches of Examples 1-13 can be further tested. To improve the difference from the existing oral tobacco strips, the present application also provides comparative examples, including:

[0080] Comparative Example 1

[0081] Calculated by mass percentage, nicotine 2%, microcrystalline cellulose 63%, cellulose derivative 7%, propylene glycol 5%, glycerol 4%, sodium chloride 5%, sodium carbonate 5%, aspartame 3%, glucose 6%, the materials are stirred at 300r / min, sealed and refrigerated at 5°C for 24h, sterilized by ultraviolet for 3 hours, and then packaged into the finished product (oral tobacco pouch).

[0082] Comparative Example 2

[0083] Calculated by mass percentage, 5% of commercially available nicotine benzoate of nicotine, 63% of microcrystalline cellulose, 7% of cellulose derivatives, 3% of propylene glycol, 3% of glycerol, 5% of sodium chloride, 5% of sodium carbonate, 3% of aspartame, and 6% of glucose are stirred and mixed at 300 r / min, sealed and refrigerated at 5°C for 24 hours, sterilized by ultraviolet light for 3 hours, and then packaged into the finished product (oral tobacco pouch).

[0084] Comparative Example 3

[0085] Calculated by mass percentage, 4% of commercially available nicotine tartrate of nicotine, 63% of microcrystalline cellulose, 7% of cellulose derivatives, 4% of propylene glycol, 13% of glycerol, 5% of sodium chloride, 5% of sodium carbonate, 3% of aspartame, and 6% of glucose are stirred at 300 r / min, sealed and refrigerated at 5°C for 24 hours, sterilized by ultraviolet light for 3 hours, and then packaged into the finished product (oral tobacco pouch).

[0086] The actual testing process includes: using the subjective smoking method to score various smoking indicators of Examples 1-13 and Comparative Examples 1-3. The smoking team has 15 people, all of whom have more than 3 years of experience in using traditional cigarettes and smokeless nicotine products, and have been nicotine-free for 10 hours before the experiment.

[0087] Each person is given a quality evaluation form, and the oral tobacco pouch with added nicotine-ion exchange resin complex is tasted by a secret evaluation method. The smoking method is: different embodiments and comparative examples are randomly coded by 3-digit numbers. The evaluators start the test at 10 am and 3 pm, and taste one sample every half day. The specific tasting process is: place the oral tobacco pouch between the upper gum and the lips. After the smoking is completed, the evaluator will score and evaluate the feeling of the head, throat hit and satisfaction through this smoking method based on the physiological feelings of the evaluator within 15 minutes (1-10 points). The scoring and evaluation are carried out according to the evaluation indicators in Table 2, and the test results are shown in Table 3 (the scoring value is the average scoring value).

[0088] Table 2

[0089]

[0090] Table 3

[0091] Headache Satisfaction Duration Example 1 powerful powerful 30-45min Example 2 Strong Strong 45-60min Example 3 Very strong Very strong 45-60min Example 4 powerful powerful 30-45min Example 5 Strong Strong 30-45min Example 6 Strong Strong 15-30min Example 7 Strong Strong 45-60min Example 8 Very strong Very strong 30-45min Example 9 Very strong Very strong 30-45min Example 10 Very strong Very strong 45-60min Embodiment 11 Very strong Very strong 30-45min Example 12 powerful powerful 45-60min Embodiment 13 Strong Strong 55-65min Comparative Example 1 Strong weak 0-15min Comparative Example 2 powerful Weaker 15-30min Comparative Example 3 Weaker powerful 15-30min

[0092] In the effects obtained from the above sensory tests, in Comparative Example 1, pure nicotine has a strong irritation that causes poor suction, resulting in a weaker feeling of being high than other salts, and a shorter duration, and a weaker sense of satisfaction; the duration of the nicotine-ion exchange resin complex is longer than that of nicotine tartrate and nicotine benzoate, and can be released evenly, slowly and persistently in the human body, providing consumers with a long-lasting and peaceful physiological satisfaction.

[0093] Further analysis shows that the amount of ion exchange resin added in Examples 1-3 is increased to ensure that the acidic ion exchange resin can fully adsorb nicotine, thereby improving the utilization rate of nicotine and enhancing the duration of nicotine release.

[0094] Compared with Example 2, Example 4 and Example 5 have different components of the auxiliary solvent, thereby increasing the solubility of nicotine in the auxiliary solvent, thereby achieving the effect of increasing the utilization rate of nicotine;

[0095] Compared with Example 2, Example 6 and Example 7 have the addition of the auxiliary solvent in the first mixed solvent, so that the free state of nicotine increases, and more impurities are dissolved and separated, thereby having the effect of improving the utilization rate of nicotine.

[0096] The difference between Example 8 and Example 2 is that the weak acid exchange resin is replaced by a strong acid exchange resin. The ions of the strong acid exchange resin are more active, thereby inhibiting the reverse change of the nicotine-ion exchange resin complex. Therefore, the stability of the nicotine-ion exchange resin complex is better, and the nicotine utilization rate is higher and more stable.

[0097] The invention of Examples 9-11 is that a strong acid ion exchange resin and a weak acid ion exchange resin are mixed and added, and the strong acid ion exchange resin and the weak acid ion exchange resin have different ratios, so that as the proportion of the strong acid ion exchange resin increases, the stability of the nicotine-ion exchange resin complex is better.

[0098] In Example 9 and Examples 12 and 13, the strong acid ion exchange resin and the weak acid ion exchange resin are added in equal amounts in an incremental manner, and the stability of the nicotine-ion exchange resin complex is better and the nicotine utilization rate is higher; and compared with the addition of a single acid ion exchange resin in Example 2, the nicotine utilization rate is higher.

[0099] The above description is only a partial or preferred embodiment of the present application. Neither the text nor the drawings can limit the scope of protection of the present application. All equivalent structural changes made using the contents of the present application specification and drawings under the overall concept of the present application, or direct / indirect application in other related technical fields are included in the scope of protection of the present application.

Claims

1. A method for preparing a nicotine-ion exchange resin complex, characterized in that: The preparation method comprises the steps of: dissolving nicotine in an auxiliary solvent to obtain a first mixed solution; adding an acidic ion exchange resin to the first mixed solution, and stirring to obtain a second mixed solution; The auxiliary solvent in the second mixed solution is filtered to obtain a wet material, and the wet material is vacuum dried to obtain a powdery nicotine-ion exchange resin complex.

2. The method for preparing the nicotine-ion exchange resin complex according to claim 1, characterized in that: The added mass ratio of the nicotine to the auxiliary solvent is 1:15-160.

3. The method for preparing the nicotine-ion exchange resin complex according to claim 2, characterized in that: The auxiliary solvent is at least one of ethanol, water and ethyl acetate.

4. The method for preparing the nicotine-ion exchange resin complex according to claim 1, characterized in that: The added mass ratio of the nicotine to the acidic ion exchange resin is 1:0.5-5.

5. The method for preparing the nicotine-ion exchange resin complex according to claim 4, characterized in that: The acidic ion exchange resin includes at least one of a strongly acidic cation exchange resin and a weakly acidic cation exchange resin; The strong acid cation exchange resin includes styrene strong acid ion exchange resin and macroporous strong acid ion exchange resin; the weak acid cation exchange resin includes isobutyric acid ion exchange resin, acrylic acid ion exchange resin and 724 weak acid ion exchange resin.

6. The method for preparing the nicotine-ion exchange resin complex according to claim 4, characterized in that: After the acidic ion exchange resin is added to the first mixed solution, the stirring speed is 250 to 350 r / min, and the stirring time is 1 to 12 hours.

7. The method for preparing the nicotine-ion exchange resin complex according to claim 6, characterized in that: The stirring time is 1 to 5 hours.

8. The method for preparing the nicotine-ion exchange resin complex according to claim 1, characterized in that: The vacuum drying has a drying temperature of 40 to 50° C. and a drying time of 2.5 to 4 hours.

9. A nicotine-ion exchange resin complex, characterized in that: The nicotine-ion exchange resin complex is prepared by the preparation method of any one of claims 1 to 8.

10. Use of the nicotine-ion exchange resin complex according to claim 9 in buccal tobacco.

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