Breathable hot-melt sealing coating film and medical packaging material

Abstract

The invention relates to a breathable hot-melt sealing coating film and a medical packaging material. The present invention provides an air-permeable hot-melt sealing coating film comprising: a polyolefin spun-bonded non-woven fabric base material; the water-based hot melt adhesive coating is coated on the polyolefin spun-bonded non-woven fabric base material and comprises a plurality of holes; wherein the coating weight of the water-based hot melt adhesive coating is between 6 g / m < 2 > and 35 g / m < 2 >, and the surface hole proportion is between 0.5% and 6.0%. The breathable hot-melt sealing coating film provided by the invention has good breathability, and has reliable sealing strength and peelability after being sealed with a flexible sheet or a blister container at the periphery.

Description

Technical Field

[0001] The present invention relates to a hot melt sealing coating for medical packaging materials, in particular to a breathable hot melt sealing coating with good air permeability. The breathable hot melt sealing coating for medical product packaging of the present invention can provide appropriate air permeability and sealing strength. Background Art

[0002] Medical supplies need to be sealed and sterilized after packaging. Therefore, the packaging material needs to form a bacteria-proof protective layer on the outside of the medical supplies to keep the medical devices sterile before use. The sterilization procedures for medical supplies after packaging usually use steam sterilization, ethylene oxide (EO) gas sterilization, electron beam sterilization, plasma sterilization and gamma radiation sterilization. During steam sterilization and EO gas sterilization, water vapor or EO gas needs to be introduced into the package to sterilize the medical supplies. Therefore, part of the packaging material must use materials with good air permeability. In the prior art, the most widely used materials that have both good microbial barrier effects and air permeability can be medical paper or a porous polyethylene non-woven fabric made by meltblowing, such as Tyvek produced by DuPont in the United States.

[0003] Such medical breathable materials, such as medical paper or porous polyethylene non-woven fabrics, are usually coated with heat-sealing adhesives to facilitate heat-sealing with various flexible sheets or plastic packaging trays. In addition to good air permeability, this medical packaging material must also have good heat-sealing strength and peelability. Insufficient heat-sealing strength will result in poor sealing of medical product packaging, which may cause bag breakage due to high gas pressure during sterilization, while excessive heat-sealing strength will make it difficult for users to tear open the package or cause dust to stick to the medical products due to pulling the fibers when tearing. Summary of the invention

[0004] The present invention provides a breathable hot-melt sealing coating film for medical packaging materials, which has good air permeability for use in steam sterilization or EO gas sterilization processes, and has reliable sealing strength and peelability after being sealed at the periphery with a flexible sheet or a plastic packaging tray.

[0005] The breathable hot melt sealing coating of the present invention comprises a polyolefin spunbond nonwoven fabric substrate; and a water-based hot melt adhesive coating coated on the polyolefin spunbond nonwoven fabric substrate, which comprises a plurality of holes. The coating amount of the water-based hot melt adhesive coating is between 6 g / m 2 Up to 35g / m 2 The surface pore ratio is between 0.5% and 6.0%.

[0006] The air permeable hot melt sealing coating of the present invention has an air permeability of less than 120 seconds / 100cc (TAPPI T-460) and a sealing strength of greater than 220g / 15mm (ASTM F-88).

[0007] The average size of the pores in the water-based hot melt adhesive coating of the breathable hot melt sealing coating of the present invention is between 2 μm 2 Up to 150μm 2 between.

[0008] The ratio (P / W) of the surface pore ratio (P) of the water-based hot melt adhesive coating of the breathable hot melt sealing coating of the present invention to the coating weight (W) is between 0.03 and 0.50.

[0009] The breathable hot melt sealing coating of the present invention comprises a water-based hot melt adhesive coating comprising 40wt% to 75wt% of a water-based adhesive resin, 15wt% to 35wt% of wax particles and 15wt% to 35wt% of tackifier particles, wherein the total amount of the wax particles and the tackifier particles accounts for between 30wt% and 60wt% of the total weight of the water-based hot melt adhesive coating.

[0010] In the breathable hot-melt sealing coating of the present invention, the weight ratio of the wax particles to the tackifier particles in the water-based hot-melt adhesive coating is between 0.6:1 and 1.5:1.

[0011] In the breathable hot-melt sealing coating of the present invention, the particle sizes of the wax particles and the tackifier particles of the water-based hot-melt adhesive coating are between 3 μm and 35 μm.

[0012] The breathable hot-melt sealing coating of the present invention, the water-based adhesive resin comprises at least one water-based polyolefin resin, and the water-based polyolefin resin can be, for example, at least one of water-based polyethylene resin, water-based polypropylene resin, water-based polybutylene resin, water-based oxidized polyethylene resin, and water-based ethylene-(meth)acrylic acid copolymer, or a combination thereof.

[0013] In the breathable hot-melt sealing coating of the present invention, the water-based adhesive resin may optionally further include a water-based ionomer, which may be, for example, at least one of a water-based polyethylene ionomer, a water-based polypropylene ionomer, a water-based polybutylene ionomer, a water-based oxidized polyethylene ionomer, or a combination thereof. The water-based ionomer may account for between 2wt% and 20wt% of the total weight of the water-based adhesive resin.

[0014] The air-permeable hot-melt sealing coating of the present invention, the aqueous hot-melt adhesive coating may selectively further contain 1wt% to 10wt% of aqueous paraffin.

[0015] The breathable hot-melt sealing coating of the present invention has a surface root mean square height (Sq) of the water-based hot-melt adhesive coating between 3.0 μm and 11 μm, a maximum height (Sz) between 30 μm and 100 μm, an arithmetic mean height (Sa) between 2.5 μm and 6.5 μm, a root mean square gradient (SΔq) between 1.00 and 3.80, and an expanded specific surface area (Sdr) between 30% and 110%.

[0016] The present invention further provides a medical packaging material, which is made by heat-sealing the above-mentioned breathable hot-melt sealing coating film and a polymer film or a polymer rigid blister.

[0017] In the medical packaging material of the present invention, the materials of the polymer film and the polymer rigid blister are polyethylene terephthalate (PET), polyethylene terephthalateco-1,4-cylclohexylenedimethylene terephthalate (PETG), polyvinyl chloride (PVC), amorphous polyethylene terephthalate (APET), polystyrene (PS), polypropylene (PP), polycarbonate (PC), polyethylene (PE) or nylon.

[0018] In the medical packaging material of the present invention, the heat-sealing strength of the breathable hot-melt sealing coating and the polymer film or polymer rigid blister is between 250g / 15mm and 450g / 15mm.

[0019] The above invention content is intended to provide a simplified description of the content of the present disclosure so that readers can have a basic understanding of the content of the present disclosure. This invention content is not a complete overview of the content of the present disclosure, and its intention is not to point out the important / key elements of the embodiments of the present invention or to define the scope of the present invention. After referring to the following embodiments, those with ordinary knowledge in the technical field to which the present invention belongs can easily understand the basic spirit of the present invention and the technical means and implementation patterns adopted by the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a scanning electron microscope image of the surface of the air-permeable hot-melt sealing coating film of Example 4 of the present invention at a magnification of 400.

[0021] Figure 2This is a scanning electron microscope image of the surface of the air-permeable hot-melt sealing coating film of Example 5 of the present invention at a magnification of 400.

[0022] Figure 3 This is a scanning electron microscope image of the surface of the air-permeable hot-melt sealing coating film of Example 6 of the present invention at a magnification of 400.

[0023] Figure 4 This is a scanning electron microscope image of the surface of the air-permeable hot-melt sealing coating film of Example 7 of the present invention at a magnification of 400.

[0024] Explanation of symbols

[0025] 100: Breathable hot melt sealing coating DETAILED DESCRIPTION

[0026] In order to make the description of the disclosure of the present invention more detailed and complete, the following is an illustrative description of the implementation and specific embodiments of the present invention; however, this is not the only form of implementing or using the specific embodiments of the present invention. The embodiments disclosed below can be combined or replaced with each other under beneficial circumstances, and other embodiments can be added to each embodiment without further recording or explanation.

[0027] The advantages, features and technical methods achieved by the present invention will be described in more detail with reference to exemplary embodiments so as to be more easily understood, and the present invention may be implemented in different forms, so it should not be understood as being limited to the embodiments described herein. On the contrary, for those with ordinary knowledge in the relevant technical field, the provided embodiments will make the present disclosure more thorough and comprehensive and completely convey the scope of the present invention, and the present invention will only be defined by the appended claims.

[0028] Unless otherwise defined, all terms (including technical and scientific terms) and proper nouns used in the following text have essentially the same meaning as generally understood by technical personnel in the field to which the present invention belongs. For example, those terms defined in commonly used dictionaries should be understood to have meanings consistent with the content of the relevant field, and unless clearly defined in the following text, they will not be understood in an overly idealized or overly formal sense.

[0029] The "air permeability" mentioned herein refers to the air resistance of gas passing through a breathable sheet, which is measured according to TAPPI T-460 standard as the air resistance of 100cc of gas passing through a circular area of ​​about 1 square inch at a pressure difference of 1.22 kPa.

[0030] The "seal strength" referred to herein refers to the tensile force required to separate two sealed flexible sheets, which is measured in a "T-separation" test at a tensile speed of 200 mm / min according to ASTM F88.

[0031] The "surface hole ratio (%)" mentioned in this article refers to the surface hole ratio (%) of the water-based hot melt adhesive coating of the breathable hot melt sealing coating. The calculation is to cut the breathable hot melt sealing coating into an appropriate size and stick it on a carrier. After electroplating the sample with a platinum target, the carrier is placed in a Hitachi S-4300 cold field emission scanning electron microscope (CFE-SEM) and measured at a magnification of 60 times to obtain an image map of 1280x960 pixels (length 2133μm and width 1600μm). The image analysis software ImageJ (developed by the National Institutes of Health NIH of the United States) is used to select the hole shadow by the difference in image depth, and the ratio of the hole shadow area to the overall image map area is calculated to obtain the surface hole ratio (%).

[0032] The "coating amount" mentioned in this article refers to the weight of the coating applied on each square meter of substrate (g / m 2 ).

[0033] The breathable hot melt sealing coating disclosed in the present invention has good air permeability, so that the breathable hot melt sealing coating and the flexible sheet or blister container can be sterilized by steam or EO gas after the periphery is heat-sealed, so as to meet the appropriate sterilization requirements of the contents of the medical packaging, and there will be no problem of fiber shedding and dust pollution of the equipment when the packaging is torn off. The breathable hot melt sealing coating of the present invention comprises a polyolefin-based spunbond nonwoven fabric substrate; and a water-based hot melt adhesive coating coated on the substrate, and the coating amount of the water-based hot melt adhesive coating can be between 6g / m 2 Up to 35g / m 2 and the surface pore ratio can be between 0.5% and 6.0%.

[0034] The water-based hot melt adhesive coating of the breathable hot melt sealing coating of the present invention contains a high total amount of particles so that the coating has appropriate interstices while still providing the expected sealing strength and adhesion to the non-woven fabric substrate. The air permeability of the breathable hot melt sealing coating of the present invention can be less than 120 seconds / 100cc (TAPPI T-460), preferably less than 100 seconds / 100cc, and the sealing strength can be greater than 220g / 15mm (ASTM F-88), preferably greater than 250g / 15mm.

[0035] The average size of the pores in the water-based hot melt adhesive coating of the breathable hot melt sealing coating of the present invention can be between 2 μm 2 Up to 150μm 2 between.

[0036] The water-based hot melt adhesive coating of the breathable hot melt sealing coating of the present invention preferably has a water-based hot melt adhesive coating weight (W) of between 6 g / m 2 Up to 30g / m 2 and the ratio (P / W) of the surface pore ratio (P) to the coating amount (W) of the water-based hot melt adhesive coating is preferably between 0.03 and 0.50.

[0037] The polyolefin spunbond nonwoven fabric substrate suitable for the breathable hot melt sealing coating of the present invention can be selected from the base weight of 40 g / m2 widely used in medical packaging. 2 Up to 80g / m 2 DuPont For example 1073B, 1059B, 2FS, etc., but not limited to.

[0038] The breathable hot melt sealing coating of the present invention comprises a water-based hot melt adhesive coating comprising 40wt% to 75wt% of a water-based adhesive resin, 15wt% to 35wt% of wax particles and 15wt% to 35wt% of tackifier particles, wherein the total amount of the wax particles and the tackifier particles accounts for between 30wt% and 60wt% of the total weight of the water-based hot melt adhesive coating.

[0039] In the breathable hot-melt sealing coating of the present invention, the weight ratio of the wax particles to the tackifier particles in the water-based hot-melt adhesive coating is between 0.6:1 and 1.5:1.

[0040] In the breathable hot melt sealing coating of the present invention, the particle sizes of the wax particles and the tackifier particles of the water-based hot melt adhesive coating are between 3 μm and 35 μm, preferably between 3 μm and 30 μm.

[0041] The particle components contained in the water-based hot melt adhesive coating of the breathable hot melt sealing coating of the present invention can maintain the coating with appropriate gaps to achieve air permeability without affecting the stability of the coating surface. When the breathable hot melt sealing coating is sealed with a flexible sheet or a blister container to package medical devices, if the roughness of the water-based hot melt adhesive coating of the breathable hot melt sealing coating is too high, the strength of the coating surface will be insufficient, and the surface of the breathable hot melt sealing coating will be easily detached by the water-based hot melt adhesive coating due to the movement of the medical device, thereby contaminating the medical device.

[0042] The breathable hot melt sealing coating of the present invention has a surface roughness of a water-based hot melt adhesive coating having a root mean square height (Sq) between 3.0 μm and 11 μm, a maximum height (Sz) between 30 μm and 100 μm, an arithmetic mean height (Sa) between 2.5 μm and 6.5 μm, a root mean square gradient (SΔq) between 1.00 and 3.80, and an expanded specific surface area (Sdr) between 30% and 110%. In a preferred embodiment, the surface roughness of the water-based hot melt adhesive coating has a root mean square height (Sq) between 4.0 μm and 11 μm, a maximum height (Sz) between 35 μm and 100 μm, an arithmetic mean height (Sa) between 3.0 μm and 6.5 μm, a root mean square gradient (SΔq) between 1.30 and 3.80, and an expanded specific surface area (Sdr) between 40% and 110%.

[0043] Furthermore, the breathable hot melt sealing coating of the present invention can provide good thermal adhesion and peelability. After being sealed at the periphery with a flexible sheet or a blister container, it has the required heat sealing strength. When the packaging material is torn open, the packaging material will be stably disconnected from the adhesive layer at the heat sealing position of the water-based hot melt adhesive to maintain the heat sealing stability and reduce the pollution caused by the shedding of the substrate fibers. It will not affect the expected sealing strength between the breathable hot melt sealing coating and the flexible sheet or blister container and the adhesion between the non-woven fabric.

[0044] The water-based adhesive resin of the water-based hot melt adhesive coating of the breathable hot melt sealing coating of the present invention may include but is not limited to water-based polyolefin resins. The water-based polyolefin resin that can be used may be a hydrophilically modified polyolefin resin. The applicable water-based polyolefin resin may be, for example, water-based polyethylene resin, water-based polypropylene resin, water-based polybutylene resin, water-based oxidized polyethylene resin, water-based ethylene-(meth)acrylic acid copolymer, etc. or a combination thereof, but is not limited thereto, and the water-based hot melt adhesive coating may use one or more water-based polyolefin resins.

[0045] The water-based polyolefin resin suitable for the water-based hot melt adhesive of the present invention can be commercially available, such as ALTRIX WPE-09838 purchased from Taiwan Gonglong Chemical Company, China; SB-1030N from Japan Unitika Arrowbase Co., Ltd.; HME-118-B from the United States MICA Company, etc., but not limited thereto.

[0046] In another embodiment of the present invention, the aqueous adhesive resin may optionally further include an aqueous ionomer, such as but not limited to an aqueous polyethylene ionomer, an aqueous polypropylene ionomer, an aqueous polybutylene ionomer, an aqueous oxidized polyethylene ionomer, or the like or a combination thereof. Suitable aqueous ionomers may be commercially available, such as CHEMIPEARL purchased from Mitsui Chemicals, Inc. TMS300, S500. The aqueous ion polymer may account for 2 wt% to 20 wt% of the total weight of the aqueous adhesive resin.

[0047] The wax particles in the water-based hot melt adhesive coating are used to reduce the melt viscosity and surface viscosity of the water-based hot melt adhesive coating, but will not significantly reduce the adhesive properties of the water-based hot melt adhesive. The water-based hot melt adhesive coating of the present invention contains 15wt% to 35wt% of wax particles, and preferably between 15wt% and 30wt%. Furthermore, in order to help the water-based hot melt adhesive coating of the present invention to form a coating on a polyolefin-based spunbond non-woven fabric substrate with good air permeability, the particle size (D50) of the wax particles can be between 3μm and 35μm, and preferably between 3μm and 30μm, and especially between 5μm and 20μm.

[0048] Applicable wax particles include, for example, commercially available Fischer-Tropsch synthetic powder wax, polypropylene powder wax, polyethylene powder wax, oxidized polyethylene powder wax, microcrystalline wax, or a combination thereof, but are not limited thereto. Applicable Fischer-Tropsch synthetic powder wax may be, for example, Sasolwax Spray 30-G, Spray 30G-M, Spray 30G-EF, Spray 105, Spray 105-G, Spray 105G-EF, Sasolwax Aqua30-G, Aqua 30G-EF, etc., obtained from Sasol Chemicals Pacific Ltd. of South Africa; Applicable polypropylene powder wax may be, for example, BYK's 913, 914. Germany's Münzing Chemie MP2120, etc.; Suitable polyethylene powder waxes can be, for example, BYK 925, 929N, Münzing Chemie of Germany MO4715, etc., but not limited thereto.

[0049] The water-based hot melt adhesive coating of the present invention uses tackifier particles to increase the content of the particle component, so that the water-based hot melt adhesive coating has appropriate gaps but can still provide the expected sealing strength and adhesion between the non-woven fabric as a whole. The water-based hot melt adhesive coating of the present invention contains 15wt% to 35wt% of tackifier particles and preferably between 15wt% and 30wt%.

[0050] In order to make the water-based hot melt adhesive coating of the present invention have good air permeability and sealing strength, the particle size (D50) of the tackifier particles used in the coating is similar to the particle size (D50) of the wax particles, which can be between 3μm and 35μm, preferably between 5μm and 30μm. In the water-based hot melt adhesive coating of the present invention, the amount of tackifier particles used can be adjusted according to the amount of wax particles used, so that the total amount of particle components in the water-based hot melt adhesive coating, that is, the total amount of tackifier particles and wax particles is between 30wt% and 60wt% of the total weight of the water-based hot melt adhesive coating, and preferably between 45wt% and 60wt%. In the water-based hot melt adhesive coating, the amount of wax particles used will affect the sealing strength, so the weight ratio of wax particles to tackifier particles can be between 0.6:1 and 1.5:1, and preferably between 0.8:1 and 1.2:1.

[0051] The tackifier particles suitable for the water-based hot melt adhesive coating of the present invention can be petroleum resin powder or hydrogenated petroleum resin powder, such as C5 petroleum resin powder, C9 petroleum resin powder, C5 / C9 copolymerized petroleum resin powder, hydrogenated C9 petroleum resin powder or a combination thereof. For example, the commercially available Cray Valley Company of the United States 95. 98. STS, Extra, W-90, W-110, W-120, W-140, Regalite provided by Synthomer, UK TM R1090, Regalite TM R1125, YL-90, YL-120H etc. provided by Yuan Liang Industrial Co., Ltd., Taiwan, China, but not limited thereto.

[0052] In another embodiment of the present invention, the water-based hot melt adhesive coating may optionally further include water-based paraffin wax to improve the peelability of the breathable hot melt sealing coating film to further reduce the pollution problem of dust adhering to medical supplies caused by tearing the package and pulling the fibers. The water-based paraffin wax may account for between 1wt% and 10wt% of the total weight of the water-based hot melt adhesive coating.

[0053] The water-based hot melt adhesive coating of the breathable hot melt sealing coating of the present invention may further include other additives, such as wetting dispersants, defoamers, thickeners, etc. that are beneficial to the coating processability of the water-based hot melt adhesive; antioxidants, UV stabilizers, antibacterial agents, antistatic agents, etc. that can increase the functionality of the water-based hot melt adhesive. The types and amounts of these additives can be selected by those skilled in the art according to actual needs. The water-based hot melt adhesive coating of the breathable hot melt sealing coating of the present invention can be coated by coating methods widely used in this technical field, such as roller coating, blade coating, roller coating, spin coating, spray coating, slit coating, and air knife coating, but is not limited thereto.

[0054] The present invention further provides a medical packaging material, which is made by heat-sealing the aforementioned breathable hot-melt sealing coating and a polymer film or a polymer rigid blister. The polymer film or polymer rigid blister suitable for sealing with the breathable hot-melt sealing coating of the present invention may be made of, for example, polyethylene terephthalate (PET), polyethylene terephthalate-1,4-cyclohexanedimethanol (PETG), polyvinyl chloride (PVC), amorphous polyethylene terephthalate (APET), polystyrene (PS), polypropylene (PP), polyethylene (PE), polycarbonate (PC) or nylon, but is not limited thereto.

[0055] The breathable hot-melt sealing coating of the present invention can be thermally bonded to another packaging substrate, such as the aforementioned polymer film or polymer blister, at a temperature of 90°C to 150°C. The sealing strength after bonding is greater than 220g / 15mm, preferably between 250g / 15mm and 450g / 15mm.

[0056] The following examples are used to further illustrate the present invention, but the present invention is not limited thereto.

[0057] Example

[0058] The materials used in the embodiments of the present invention are as follows:

[0059] WPE-09838: polyethylene latex, melting point 145°C, glass transition temperature (Tg) -120°C, solid content 25%, solvent water, purchased from Taiwan Gonglong Chemical Co., Ltd., China;

[0060] Chemipearl TM S500: polyolefin ionomer latex, solid content 42%, solvent water, purchased from Mitsui Chemicals Inc. (Japan);

[0061] Chemipearl TMS300: polyolefin ionomer latex, solid content 35%, solvent water, purchased from Mitsui Chemicals Inc. (Japan);

[0062] AQUACER 497: aqueous paraffin emulsion, solid content 50%, solvent is water, melting point 60°C, purchased from BYK, Germany;

[0063] Sasolwax Spray 30G-M: Fischer-Tropsch synthetic wax, melting point 96-100°C, glass transition temperature (Tg) about -120°C, average particle size 9 to 11 μm, purchased from Sasol Limited of South Africa;

[0064] W-140: C9 petroleum resin, softening point of 140°C, glass transition temperature (Tg) of 90°C, average molecular weight (Mn) of 1200 g / mol, average particle size of 5 to 10 μm, purchased from Cray Valley Chemical Co., Ltd., USA;

[0065] BYK-3450: polyether modified siloxane wetting and dispersing agent, purchased from BYK, Germany;

[0066] BYK-025: polysiloxane defoamer, solid content 18.5%, solvent dipropylene glycol monomethyl ether, purchased from BYK, Germany;

[0067] AS1125: acrylic thickener, solid content 25%, solvent is water, purchased from BASF SE, Germany

[0068] 2FS: high-density polyethylene spunbond nonwoven fabric substrate, purchased from DuPont, USA.

[0069] Example 1.

[0070] 100 parts by weight of polyethylene latex (WPE-09838), 12.6 parts by weight of Fischer-Tropsch wax (SasolwaxSpray 30G-M), 12.6 parts by weight of C9 petroleum resin ( W-140), 0.2 parts by weight of a polyether-modified siloxane surfactant (BYK-3450), 0.13 parts by weight of a polysiloxane defoamer (BYK-025), 4.8 parts by weight of an acrylic thickener ( AS1125) and 127.5 parts by weight of deionized water were mixed and stirred for 1 hour to make them uniformly dispersed to form an aqueous hot melt adhesive solution.

[0071] The hot melt adhesive solution is applied to the 2FS polyethylene spunbond nonwoven fabric substrate, and then dried at 80℃ The coating amount formed on the 2FS substrate is 9.6g / m 2 hot melt adhesive coating to produce a breathable hot melt sealing coating.

[0072] The obtained breathable hot-melt seal coating was subjected to air permeability test, surface hole ratio calculation, heat seal strength measurement, surface roughness measurement and coating peeling evaluation according to the methods described below. The test results are shown in Table 1 below.

[0073] Example 2.

[0074] The aqueous hot melt adhesive solution prepared in Example 1 was applied to 2FS substrate, and then dried at 80℃. The coating amount formed on the 2FS substrate is 22.6g / m 2 hot melt adhesive coating to produce a breathable hot melt sealing coating.

[0075] The obtained breathable hot-melt seal coating was subjected to air permeability test, surface hole ratio calculation, heat seal strength measurement, surface roughness measurement and coating peeling evaluation according to the methods described below. The test results are shown in Table 1 below.

[0076] Example 3.

[0077] 100 parts by weight of polyethylene latex (WPE-09838), 12.6 parts by weight of Fischer-Tropsch wax (SasolwaxSpray 30G-M), 12.6 parts by weight of C9 petroleum resin ( W-140), 0.2 parts by weight of a polyether-modified siloxane surfactant (BYK-3450), 0.13 parts by weight of a polysiloxane defoamer (BYK-025), 6.0 parts by weight of an acrylic thickener ( AS1125) and 127.5 parts by weight of deionized water were mixed and stirred for 1 hour to make them uniformly dispersed to form an aqueous hot melt adhesive solution.

[0078] The hot melt adhesive solution is applied to the 2FS polyethylene spunbond nonwoven fabric substrate, and then dried at 80℃ The coating amount formed on the 2FS substrate is 13.3g / m 2 hot melt adhesive coating to produce a breathable hot melt sealing coating.

[0079] The obtained breathable hot-melt seal coating was subjected to air permeability test, surface hole ratio calculation, heat seal strength measurement, surface roughness measurement and coating peeling evaluation according to the methods described below. The test results are shown in Table 1 below.

[0080] Example 4.

[0081] 100 parts by weight of polyethylene latex (WPE-09838), 1.7 parts by weight of aqueous paraffin emulsion (AQUACER497), 9.1 parts by weight of Fischer-Tropsch wax (Sasolwax Spray 30G-M), 9.1 parts by weight of C9 petroleum resin ( W-140), 0.15 parts by weight of a polyether-modified siloxane surfactant (BYK-3450), 0.1 parts by weight of a polysiloxane defoamer (BYK-025), 4.7 parts by weight of an acrylic thickener ( AS1125) and 101.9 parts by weight of deionized water were mixed and stirred for 1 hour to make them uniformly dispersed to form an aqueous hot melt adhesive solution.

[0082] The hot melt adhesive solution is applied to the 2FS polyethylene spunbond nonwoven fabric substrate, and then dried at 80℃ The coating amount formed on the 2FS substrate is 18.5g / m 2 The hot melt adhesive coating is formed to obtain a breathable hot melt sealing coating film 100.

[0083] The surface of the obtained breathable hot-melt sealing coating film 100 is shown in a scanning electron microscope image at 400 times magnification. Figure 1 The obtained breathable hot melt sealing coating film 100 was subjected to air permeability test, surface hole ratio calculation, heat sealing strength measurement, surface roughness measurement and coating peeling evaluation according to the methods described below. The test results are shown in Table 1 below.

[0084] Example 5.

[0085] 100 parts by weight of polyethylene latex (WPE-09838), 3.4 parts by weight of aqueous polyolefin ionomer latex (Chemipearl TM S500), 7.2 parts by weight of aqueous paraffin emulsion (AQUACER 497), 8.4 parts by weight of Fischer-Tropsch wax (Sasolwax Spray 30G-M), 8.4 parts by weight of C9 petroleum resin ( W-140), 0.13 parts by weight of a polyether-modified siloxane surfactant (BYK-3450), 0.09 parts by weight of a polysiloxane defoamer (BYK-025), 5.3 parts by weight of an acrylic thickener ( AS1125) and 107.6 parts by weight of deionized water were mixed and stirred for 1 hour to make them uniformly dispersed to form an aqueous hot melt adhesive solution.

[0086] The hot melt adhesive solution is applied to the 2FS polyethylene spunbond nonwoven fabric substrate, and then dried at 80℃ The coating amount formed on the 2FS substrate is 17.5g / m 2 The hot melt adhesive coating is formed to obtain a breathable hot melt sealing coating film 100.

[0087] The surface of the obtained breathable hot-melt sealing coating film 100 is shown in a scanning electron microscope image at 400 times magnification. Figure 2 The obtained breathable hot melt sealing coating film 100 was subjected to air permeability test, surface hole ratio calculation, heat sealing strength measurement, surface roughness measurement and coating peeling evaluation according to the methods described below. The test results are shown in Table 1 below.

[0088] Example 6.

[0089] 100 parts by weight of polyethylene latex (WPE-09838), 6.0 parts by weight of aqueous polyolefin ionomer latex (Chemipearl TM S300), 4.3 parts by weight of aqueous paraffin emulsion (AQUACER 497), 11.7 parts by weight of Fischer-Tropsch wax (Sasolwax Spray 30G-M), 11.7 parts by weight of C9 petroleum resin ( W-140), 0.19 parts by weight of a polyether-modified siloxane surfactant (BYK-3450), 0.12 parts by weight of a polysiloxane defoamer (BYK-025), 6.0 parts by weight of an acrylic thickener ( AS1125) and 130.4 parts by weight of deionized water were mixed and stirred for 1 hour to make them uniformly dispersed to form an aqueous hot melt adhesive solution.

[0090] The hot melt adhesive solution is applied to the 2FS polyethylene spunbond nonwoven fabric substrate, and then dried at 80℃ The coating amount formed on the 2FS substrate is 18.5g / m 2 The hot melt adhesive coating is formed to obtain a breathable hot melt sealing coating film 100.

[0091] The surface of the obtained breathable hot-melt sealing coating film 100 is shown in a scanning electron microscope image at 400 times magnification. Figure 3The obtained breathable hot melt sealing coating film 100 was subjected to air permeability test, surface hole ratio calculation, heat sealing strength measurement, surface roughness measurement and coating peeling evaluation according to the methods described below. The test results are shown in Table 1 below.

[0092] Example 7.

[0093] 100 parts by weight of polyethylene latex (WPE-09838), 3.1 parts by weight of aqueous polyolefin ionomer latex (Chemipearl TM S300), 4.2 parts by weight of aqueous paraffin emulsion (AQUACER 497), 11.6 parts by weight of Fischer-Tropsch wax (Sasolwax Spray 30G-M), 11.6 parts by weight of C9 petroleum resin ( W-140), 0.19 parts by weight of a polyether-modified siloxane surfactant (BYK-3450), 0.12 parts by weight of a polysiloxane defoamer (BYK-025), 5.9 parts by weight of an acrylic thickener ( AS1125) and 127.8 parts by weight of deionized water were mixed and stirred for 1 hour to make them uniformly dispersed to form an aqueous hot melt adhesive solution.

[0094] The hot melt adhesive solution is applied to the 2FS polyethylene spunbond nonwoven fabric substrate, and then dried at 80℃ The coating amount formed on the 2FS substrate is 18.5g / m 2 The hot melt adhesive coating is formed to obtain a breathable hot melt sealing coating film 100.

[0095] The surface of the obtained breathable hot-melt sealing coating film 100 is shown in a scanning electron microscope image at 400 times magnification. Figure 4 The obtained breathable hot melt sealing coating film 100 was subjected to coating coating amount measurement, air permeability test, surface hole ratio calculation, heat sealing strength measurement, surface roughness measurement and coating peeling evaluation according to the methods described below. The test results are shown in Table 1 below.

[0096] Coating weight measurement, air permeability test, surface hole ratio calculation, heat seal strength measurement, surface roughness measurement and coating peeling evaluation method.

[0097] Coating weight measurement: Using a circular cutter (Sample Cutter 240 / 100, purchased from Hans Schmidt & Co GmbH, Germany), according to the test standard of EN ISO 536, the weight of the aforementioned water-based hot melt adhesive coated non-woven fabric and the polyethylene spunbond non-woven fabric substrate before coating were measured respectively. The weight of the water-based hot melt adhesive coating was obtained by subtracting the two. The unit is grams per square meter (g / m2).2 (gsm).

[0098] Air permeability test: using an air permeability tester (Gurley type Densometer Model 4980-D, purchased from Liansheng Instrument Co., Ltd., Taiwan, China), according to the test standard of TAPPI T-460, the average number of seconds required for 100cc of air to pass through the aforementioned breathable hot-melt sealing coating film was measured.

[0099] Measurement of sealing strength: Using a heat sealing tester BS-25 (purchased from Daba Precision Machinery Industrial Co., Ltd., Taiwan, China), set the upper plate temperature to 123 degrees, the lower plate temperature to room temperature, the heat sealing pressure to 1.5 kg and the pressing seconds to 1.5 seconds, the breathable hot-melt sealing coating film covered with a transparent HDPE film and Teflon cloth in sequence on the top is heat-pressed, and the resulting sealed product is cut into 15 mm wide strip specimens. Using a tensile testing machine AI-3000 (purchased from Taiwan High Speed ​​Rail Technology Co., Ltd., China), the maximum tensile value is measured according to the description of ASTM F-88, which is the sealing strength.

[0100] Calculation of surface hole ratio (%) and average hole size: The breathable hot-melt sealing film was cut into appropriate sizes and pasted on a carrier. After platinum target material was used to electroplate the sample, the carrier was placed in a Hitachi S-4300 cold field emission scanning electron microscope (CFE-SEM) and measured at 60 times magnification to obtain an image map of 1280x960 pixels (length 2,133μm and width 1,600μm). The image analysis software ImageJ (developed by the National Institutes of Health, NIH, USA) was used to select the hole shadow by the difference in image depth, and the ratio of the hole shadow area to the overall image map area was calculated to obtain the surface hole ratio (%), and the area used for counting (count) is the average hole size (μm 2 ).

[0101] Surface roughness measurement: OLYMPUS LEXT OLS5000-SAF 3D laser confocal microscope and MPLAPON20xLEXT objective lens 640╳640μm 2 The surface roughness of the surface was measured by taking three 3D surface roughness images of an area of ​​​​the surface. According to the surface roughness description of ISO 25178-2:2012, the root mean square height (Sq), arithmetic mean height (Sa), maximum height (Sz), root mean square gradient (inclination angle) (SΔq) and developed surface area ratio (Sdr) were measured. Each test was performed 3 times and the average value was taken.

[0102] Evaluation of coating peeling: 3M 810 tape was adhered to the coating surface of the breathable hot-melt sealing film, and the tape was removed after lightly pressing back and forth with the fingertips to observe whether the coating peeled off on the tape surface. If no coating residue was found on the tape surface, it was evaluated as "excellent" (0); if coating residue was found on the tape surface, it was evaluated as "poor" (×).

[0103] Table 1: Test results of embodiments and comparative examples

[0104]

[0105]

[0106] It can be seen from Table 1 that the breathable hot-melt sealing coating films prepared in Examples 1 to 7 not only have good air permeability, but also have sufficient sealing strength after being heat-sealed with the HDPE film. Figures 1 to 4 4 is a scanning electron microscope image of the surface of the air-permeable hot-melt sealing coating film 100 of Examples 4 to 7 at a magnification of 400.

[0107] Although the present invention has been disclosed as above by way of embodiments, it is not intended to limit the present invention. Anyone skilled in the art may make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the protection scope of the present invention shall be determined by the definition of the appended claims.

Claims

1. A breathable hot-melt sealing coating film, comprising: Polyolefin-based spunbond nonwoven fabric substrate; and A water-based hot melt adhesive coating coated on the polyolefin-based spunbond nonwoven fabric substrate, the coating comprising a plurality of holes; The coating amount of the water-based hot melt adhesive coating is between 6g / m 2 Up to 35g / m 2 and the surface pore ratio is between 0.5% and 6.0%.

2. The breathable hot-melt sealing coating according to claim 1, wherein the air permeability of the breathable hot-melt sealing coating is less than 120 seconds / 100cc and the sealing strength is greater than 220g / 15mm.

3. The breathable hot melt sealing coating according to claim 1, wherein the average size of the pores of the water-based hot melt adhesive coating is between 2 μm and 2 Up to 150μm 2 between.

4. The breathable hot-melt sealing coating according to claim 1, wherein the ratio of the surface pore ratio to the coating amount of the water-based hot-melt adhesive coating is between 0.03 and 0.

50.

5. The breathable hot-melt sealing coating according to claim 1, wherein the surface root mean square height of the water-based hot-melt adhesive coating is between 3.0 μm and 11 μm, the maximum height is between 30 μm and 100 μm, the arithmetic mean height is between 2.5 μm and 6.5 μm, the root mean square gradient is between 1.00 and 3.80, and the developed specific surface area is between 30% and 110%.

6. The breathable hot-melt sealing coating according to claim 1, wherein the water-based hot-melt adhesive coating comprises 40wt% to 75wt% of a water-based adhesive resin, 15wt% to 35wt% of wax particles and 15wt% to 35wt% of tackifier particles, wherein the total amount of the wax particles and the tackifier particles accounts for between 30wt% and 60wt% of the total weight of the water-based hot-melt adhesive coating.

7. The breathable hot-melt sealing coating according to claim 6, wherein the weight ratio of the wax particles to the tackifier particles in the water-based hot-melt adhesive coating is between 0.6:1 and 1.5:

1. 8 . The breathable hot-melt sealing coating according to claim 6 , wherein the particle sizes of the wax particles and the tackifier particles in the water-based hot-melt adhesive coating are between 3 μm and 35 μm.

9. The breathable hot-melt sealing coating according to claim 6, wherein the water-based adhesive resin comprises at least one water-based polyolefin resin, and the water-based polyolefin resin is at least one selected from the group consisting of water-based polyethylene resin, water-based polypropylene resin, water-based polybutylene resin, water-based oxidized polyethylene resin, and water-based ethylene-(meth)acrylic acid copolymer, or a combination thereof.

10. The breathable hot-melt sealing coating according to claim 9, wherein the water-based adhesive resin further comprises a water-based ionomer, and the water-based ionomer is at least one selected from the group consisting of water-based polyethylene ionomer, water-based polypropylene ionomer, water-based polybutylene ionomer and water-based oxidized polyethylene ionomer or a combination thereof.

11. The breathable hot-melt sealing coating according to claim 10, wherein the aqueous ion polymer accounts for between 2 wt% and 20 wt% of the total weight of the aqueous adhesive resin.

12. The breathable hot melt sealing coating according to claim 6, wherein the aqueous hot melt adhesive coating further comprises 1 wt% to 10 wt% of aqueous paraffin.

13. A medical packaging material, which is made by heat-sealing the breathable hot-melt sealing coating film according to claim 1 and a polymer film or a polymer rigid blister.

14. The medical packaging material according to claim 13, wherein the material of the polymer film and the polymer rigid blister is polyethylene terephthalate, polyethylene terephthalate-1,4-cyclohexanedimethanol ester), polyvinyl chloride, non-crystallized polyethylene terephthalate, polystyrene, polypropylene, polyethylene film, polycarbonate or nylon.

15. The medical packaging material according to claim 13, wherein the heat-sealing strength between the breathable hot-melt sealing coating and the polymer film or the polymer rigid blister is between 250g / 15mm and 450g / 15mm.

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