Capsule for improving memory containing omega 3 and method for preparing the same

Abstract

The application discloses a capsule containing Omega 3 and capable of improving memory and a preparation method thereof, and belongs to the field of health-care food. The capsule comprises the following components: a composition containing Omega 3, polyglycerol polyricinoleate, tocopherol acetate and pure water, wherein the composition containing Omega 3 comprises Omega 3, sophora extract, sophora flower extract and khorasan milkvetch extract. The composition containing Omega 3 provided by the application is prepared by compounding the raw materials, thereby achieving the effect of significantly improving memory.

Description

Technical Field

[0001] The present invention relates to the field of health-care foods, and in particular to a capsule containing Omega 3 for improving memory and a preparation method thereof. Background Art

[0002] With the accelerating pace of modern society and the increasing aging of the population, memory loss has become a widespread concern. Memory, as an essential component of human cognitive function, is crucial for daily life, learning, and work. However, the causes of memory loss are diverse, including aging, unhealthy lifestyle habits, psychological stress, and brain and systemic diseases. These factors not only affect an individual's quality of life but may also indicate more serious cognitive impairments, such as neurodegenerative diseases like Alzheimer's disease.

[0003] The need to improve memory is self-evident. Good memory is key to maintaining independence and social participation, and is also an important preventative measure against cognitive decline and dementia. Furthermore, maintaining memory is crucial for improving work efficiency and academic achievement.

[0004] In the search for methods to improve memory, combinations of animal and plant extracts have shown great potential and value. Traditional Chinese Medicine believes that memory loss is related to heart-kidney disharmony and brain marrow malnutrition. Animals and plants, through their abundant natural active ingredients such as peptides, fatty acids, flavonoids, terpenes, and polyphenols, can effectively improve memory. Modern pharmacological research has also confirmed that certain active ingredients in animal and plant extracts, such as fatty acids, flavonoids, phenols, and alkaloids, can improve learning and memory by increasing antioxidant enzyme activity in brain tissue and reducing lipid peroxidation products. These combinations of animal and plant extracts not only have neuroprotective effects but may also work by regulating neurotransmitters and increasing cerebral blood flow.

[0005] Based on this, it is urgent to develop a composition comprising animal / plant extracts that can improve memory for consumers to choose. Summary of the Invention

[0006] The purpose of the present invention is to provide a capsule containing Omega 3 for improving memory and a preparation method thereof, wherein the capsule containing Omega 3 for improving memory includes a composition containing Omega 3, and the composition is compounded with natural active ingredients and has a significant effect of improving memory.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] In a first aspect, the present invention provides a composition containing Omega 3, comprising the following ingredients: Omega 3, sophora bean extract, sophora flower extract, and jujube extract.

[0009] Preferably, the composition containing Omega 3 comprises the following raw materials in parts by weight:

[0010] Omega3: 4-6 servings;

[0011] Sophora bean extract: 10-13 parts;

[0012] Sophora japonica flower extract: 5-7 parts;

[0013] Ziziphus jujuba extract: 20-25 parts.

[0014] Most preferably, the composition containing Omega 3 comprises the following raw materials in parts by weight:

[0015] Omega3: 5 parts;

[0016] Sophora bean extract: 12 parts;

[0017] Sophora japonica flower extract: 6 parts;

[0018] Ziziphus jujuba extract: 23 parts.

[0019] In a second aspect, the present invention provides a use of the composition containing Omega 3 described in the first aspect in preparing a health product.

[0020] Preferably, the health product is a health product containing Omega 3 for improving memory.

[0021] Preferably, the health product dosage form is any one of capsules, tablets, and granules.

[0022] In a third aspect, the present invention provides a capsule containing Omega 3 for improving memory, wherein the capsule comprises capsule contents and a capsule shell, wherein the capsule contents include the following components in percentage by mass:

[0023] 80-90 wt% of the Omega 3-containing composition of the first aspect;

[0024] Polyglycerol polyricinoleate 4-5wt%;

[0025] Tocopheryl acetate 1-3 wt%;

[0026] Complete with drinking water.

[0027] Preferably, the capsule shell is a soft capsule shell or a hard capsule shell.

[0028] More preferably, the capsule shell is a soft capsule shell.

[0029] In a fourth aspect, the present invention provides a method for preparing the capsule according to the third aspect, the method comprising the following steps:

[0030] S1: Mixing the Sophora bean extract, Sophora flower extract, and Ziziphus jujuba extract with drinking water to obtain a mixed solution A;

[0031] S2: Ultrasonic mixing of Omega-3, polyglycerol ricinoleate, and tocopheryl acetate to obtain a mixed solution B;

[0032] S3: Mixing the mixed solution A and the mixed solution B, and performing ultrasonic vibration to obtain the contents of the capsule;

[0033] S4: Place the capsule contents in a capsule shell to prepare a capsule preparation, sterilize, seal, and store at room temperature away from light.

[0034] Preferably, the capsule preparation in step S4 is a soft capsule preparation.

[0035] Compared with the prior art, the present invention has the following beneficial effects: the present invention provides a capsule containing Omega3 for improving memory and a preparation method thereof, the capsule comprising the following components: a composition containing Omega3, polyglycerol polyricinoleate, tocopheryl acetate, and purified water, wherein the composition containing Omega3 is compounded by Omega3, sophora bean extract, sophora flower extract, and jujube extract, wherein the sophora flower extract is rich in flavonoids and has significant antioxidant capacity; Omega3 fatty acids, especially DHA and EPA, also have strong antioxidant properties, which can reduce the damage of oxidative stress to the brain, enhance the brain's antioxidant defense system, and protect nerve cells; the active ingredients in the sophora flower extract and the jujube extract can also enhance cognitive function by regulating neurotransmitters and protecting nerve cells, thereby improving memory; the sophora bean extract, sophora flower extract, and jujube extract have strong anti-inflammatory activity, which can help reduce neuroinflammation and improve memory; Omega3 fatty acids, together with the alkaloids and flavonoids contained in the sophora bean and sophora flower, can effectively improve nerve cell function and signal transmission, further enhancing neural metabolism and cognitive function. Therefore, the combined use of Omega3, Sophora japonica flower extract, Sophora japonica bean extract, and Ziziphus jujuba extract can work together through multiple mechanisms such as anti-oxidation, neuroprotection, anti-inflammation, and improvement of neural metabolism, thereby playing a synergistic role in improving memory. DETAILED DESCRIPTION

[0036] In order to better understand the present invention, the present invention is further described below in conjunction with specific examples. The terms used in the examples are for describing specific embodiments and do not constitute a limitation on the scope of protection of the present invention.

[0037] The experimental methods in the following examples, where specific conditions are not specified, are generally based on conventional conditions or conditions recommended by the manufacturer. Unless otherwise specified, percentages and parts are calculated by weight.

[0038] Some of the raw materials and their sources are as follows:

[0039] Omega3: purchased from Cargill Grain and Oil (Nantong) Co., Ltd.

[0040] Sophora bean extract: purchased from Shaanxi Xinyanghe Biotechnology Co., Ltd., product number: XYHHJ-001.

[0041] Sophora japonica flower extract: purchased from Yuanpeptide Biotechnology (Tianjin) Co., Ltd.

[0042] Ziziphus jujuba extract: purchased from Xi'an Beijinuo Biotechnology Co., Ltd., product number: BJN89793.

[0043] Polyglycerol polyricinoleate: purchased from Hefei Tianjian Chemical Co., Ltd., CAS: 29894-35-7.

[0044] Tocopherol acetate: purchased from Jiangsu Plus Biotechnology Co., Ltd.

[0045] The raw materials and weight percentages of a composition containing Omega 3 are as follows:

[0046] Composition 1: Omega 3: 5 parts, Sophora japonica extract: 12 parts, Sophora japonica flower extract: 6 parts, Ziziphus jujuba extract: 23 parts.

[0047] Composition 2: Omega 3: 4 parts, Sophora japonica extract: 10 parts, Sophora japonica flower extract: 5 parts, Ziziphus jujuba extract: 20 parts.

[0048] Composition 3: Omega 3: 6 parts, Sophora japonica extract: 13 parts, Sophora japonica flower extract: 7 parts, Ziziphus jujuba extract: 25 parts.

[0049] Composition ①: The difference from composition 1 is that the locust bean extract is missing, and the reduced mass fraction thereof is distributed proportionally to other raw materials.

[0050] Composition ②: The difference from composition 1 is that the Sophora japonica flower extract is missing, and its reduced mass fraction is distributed proportionally to other raw materials.

[0051] Composition ③: The difference from composition 1 is that the jujube extract is missing, and the reduced mass portion is distributed to other raw materials in proportion.

[0052] Composition ④: The difference from composition 1 is that Omega 3 is missing, and its reduced mass fraction is distributed proportionally to other raw materials.

[0053] Composition ⑤: Omega 3: 12 parts, Sophora japonica extract: 5 parts, Sophora japonica flower extract: 23 parts, Ziziphus jujuba extract: 6 parts.

[0054] A capsule containing Omega 3 for improving memory, comprising a gelatin soft capsule shell and capsule contents, wherein the mass percentages of the components in the capsule contents are as follows:

[0055] Capsule content 1: 85 wt% of a composition containing Omega 3 (composition 1); 5 wt% of polyglycerol polyricinoleate; 2 wt% of tocopherol acetate, supplemented with drinking water.

[0056] Capsule content 2: 90 wt% of the composition containing Omega 3 (composition 1); 4 wt% of polyglycerol polyricinoleate; 1 wt% of tocopherol acetate, supplemented with drinking water.

[0057] Capsule content 3: 80 wt% of the composition containing Omega 3 (composition 1); 4 wt% of polyglycerol polyricinoleate; 3 wt% of tocopherol acetate, supplemented with drinking water.

[0058] Capsule content ①: The difference from capsule content 1 is that glyceryl monostearate is used instead of polyglyceryl ricinoleate.

[0059] The preparation method of capsule 1 is as follows:

[0060] S1: Mixing the Sophora bean extract, Sophora flower extract, and Ziziphus jujuba extract with drinking water to obtain a mixed solution A;

[0061] S2: Ultrasonic mixing of Omega-3, polyglycerol ricinoleate, and tocopheryl acetate to obtain a mixed solution B, wherein the ultrasonic frequency is 40 kHz, the ultrasonic temperature is room temperature, and the ultrasonic time is 10 min;

[0062] S3: Mixing the mixed solution A and the mixed solution B, and ultrasonically vibrating them to obtain capsule content 1, wherein the ultrasonic frequency is 40 kHz, the ultrasonic temperature is room temperature, and the ultrasonic time is 10 min;

[0063] S4: Place the capsule contents 1 in a gelatin soft capsule shell to prepare a soft capsule preparation, sterilize, seal, and store at room temperature away from light.

[0064] The preparation method of capsule 2 is different from that of capsule 1 in that capsule content 1 is replaced by capsule content 2, and the remaining steps are the same.

[0065] The preparation method of capsule 3 is different from that of capsule 1 in that capsule content 1 is replaced by capsule content 3, and the remaining steps are the same.

[0066] Preparation method of capsule ①:

[0067] The preparation method is the same as that of capsule 1. The difference from capsule 1 is that capsule content 1 is replaced by capsule content ①, and the remaining steps are the same.

[0068] Memory improvement test

[0069] Experimental animals: SPF grade SD rats, 8 weeks old, half male and half female, adapted for 1 week.

[0070] Animal modeling: Cognitive dysfunction model: A cognitive dysfunction model was established by chronic scopolamine (Scop) treatment (Deng, G., Wu, C., Rong, X., Li, S., Ju, Z., Wang, Y., Ma, C., Ding, W., Guan, H., Chen, X., Liu, W., Wang, C., 2019. Ameliorative effect of deoxyvasicine on scopolamine-induced cognitive dysfunction by restoration of cholinergic function in mice. Phytomedicine 63, 153007.). In the present invention, except for the normal control group, all other groups received chronic Scop modeling. Scop (CAS number: 51-34-3; MedChemExpress) was intraperitoneally injected daily for 1 week at a dose of 1 mg / kg to establish cognitive dysfunction in mice.

[0071] Experimental Animal Grouping: Rats were randomly divided into eight experimental groups, one model control group, and one normal control group. The experimental and model control groups were model rats, and the normal control group was normal rats, with nine rats in each group. The normal and model control groups were gavaged with the same volume of normal saline, while the experimental groups were gavaged with the corresponding sample at 0.8 g / kg for 14 consecutive days, once daily.

[0072] Drug concentration: Compositions 1-3 and compositions ①-⑤ were prepared into 85 wt% aqueous solutions using drinking water and then administered orally. Capsules 1-3 and capsule ① were administered orally without dilution. The sample mass of compositions 1-3 and compositions ①-⑤ was the mass of the aqueous solution of the composition, and the sample mass of capsules 1-3 and capsule ① was the mass of the capsule contents.

[0073] Water maze setup: The Morris water maze has a diameter of 1.65 m, with black inner walls and bottom. The water maze is divided into four quadrants. A 12-cm-diameter black platform is placed 2 cm below the water surface in the center of the second quadrant. After each water change in the water maze test, a certain amount of black dye is added to make the water black and opaque. The water temperature is maintained at 20 ± 2°C during the test.

[0074] Experimental training: From the 2nd to the 14th day after drug administration, a positioning navigation test was conducted. During the positioning navigation test, each rat was trained 4 times a day with an interval of 10 minutes. During training, a water entry point was randomly selected and the rat was placed in the water facing the pool wall. The rat entered the water from 4 different water entry points for 4 training sessions. The time required for each rat to enter the water from four different points until it found the underwater platform was recorded. If the rat could not find the platform within 120 seconds, the experimenter would take it to the platform to rest for 15 seconds before the next test. The training was conducted 4 times a day with an interval of 120 minutes between each training session.

[0075] Space Exploration Experiments:

[0076] Experimental method: On the 15th day, the rats were placed into the water from three randomly selected water entry points. The timing started from each entry into the water and stopped when the rats found the original platform position. The latency period was the average of the time taken to find the original platform position three times.

[0077] During the water maze test, reference objects such as lights around the water maze remained unchanged to avoid environmental interference.

[0078] The experimental data were rounded to two decimal places.

[0079] Table 1 Data on the effect of the composition on improving memory

[0080]

[0081]

[0082] Note: “*” indicates comparison with model control group, p < 0.05; “#” indicates comparison with composition 1, p < 0.05; “&” indicates comparison with capsule 1, p < 0.05.

[0083] According to the experimental results in Table 1, compositions 1-3 have significant effects on improving memory. By comparing composition 1 with compositions ①-④, it can be seen that in the composition containing Omega3 of the present invention, there is a certain synergistic effect between Omega3, sophora bean extract, sophora flower extract, and jujube extract; by comparing the results of composition 1 with composition ⑤, it can be seen that Omega3, sophora bean extract, sophora flower extract, and jujube extract in the present invention have better effects when used in a specific mass ratio; by comparing capsules 1-3 with composition 1, it can be seen that the encapsulation of polyglycerol ricinoleate, tocopheryl acetate and soft capsules helps to promote the absorption of the composition containing Omega3. By comparing capsule 1 with capsule ①, it can be seen that polyglycerol ricinoleate can more significantly promote the absorption of the composition containing Omega3 than glyceryl monostearate.

[0084] The embodiments described above are some embodiments of the present invention, rather than all embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but merely represents selected embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection claimed by the present invention.

Claims

1. A composition containing Omega 3, characterized in that The composition is composed of the following raw materials in parts by mass: Omega3: 4-6 servings; Sophora bean extract: 10-13 parts; Sophora japonica flower extract: 5-7 parts; Ziziphus jujuba extract: 20-25 parts.

2. The composition according to claim 1, characterized in that The composition is composed of the following raw materials in parts by mass: Omega3: 5 parts; Sophora bean extract: 12 parts; Sophora japonica flower extract: 6 parts; Ziziphus jujuba extract: 23 parts.

3. Use of the composition as claimed in claim 1 or 2 in the preparation of health care products.

4. The application according to claim 3, characterized in that The health care product is a health care product containing Omega 3 and improving memory.

5. The application according to claim 4, characterized in that: The health care product dosage form is any one of capsules, tablets, and granules.

6. A capsule containing Omega 3 for improving memory, characterized in that: The capsule comprises capsule contents and a capsule shell, wherein the capsule contents include the following components in mass percentage: 80-90 wt % of the Omega 3 composition according to claim 1 or 2; Polyglycerol polyricinoleate 4-5wt%; Tocopheryl acetate 1-3wt%; Complete with drinking water.

7. A method for preparing the capsule according to claim 6, characterized in that: The preparation method comprises the following steps: S1: Mixing the Sophora bean extract, Sophora flower extract, and Ziziphus jujuba extract with drinking water to obtain a mixed solution A; S2: Ultrasonic mixing of Omega-3, polyglycerol ricinoleate, and tocopheryl acetate to obtain a mixed solution B; S3: Mixing the mixed solution A and the mixed solution B, and performing ultrasonic vibration to obtain the contents of the capsule; S4: Place the capsule contents in a capsule shell to prepare a capsule preparation, sterilize, seal, and store at room temperature away from light.

8. The method for preparing the capsule according to claim 7, characterized in that: The capsule preparation in step S4 is a soft capsule preparation.

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