Portable traditional Chinese medicine drenching and soaking fast disintegration and mixing effervescent tablet and preparation method thereof

Abstract

The invention relates to a portable traditional Chinese medicine drenching and soaking rapidly disintegrated and mixed effervescent tablet and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The invention provides an effervescent tablet for treating eczematous dermatitis. The effervescent tablet is prepared from the following components in parts by mass: 10 to 40 parts of extract powder, 20 to 30 parts of citric acid, 15 to 25 parts of sodium bicarbonate, 1 to 3 parts of polyvinylpyrrolidone absolute ethyl alcohol solution, 1 to 9 parts of polyethylene glycol 6000, 15 to 30 parts of lactose and 3 to 7 parts of sodium carboxymethyl cellulose. The effervescent tablet obtained by the preparation method is convenient to use, convenient to carry and store, short in disintegration time, proper in pH value, large in foaming amount, smooth in appearance and clear in solution after disintegration, and the superfine powder for preparing the extract powder can improve the drug wall breaking rate, promote dissolution of effective components, improve the bioavailability and the treatment effect, improve the resource utilization rate and reduce the production cost. The invention provides a brand new dosage form of external medicine for treating eczematous dermatitis.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine preparations, and in particular to a portable Chinese medicine soaked, fast-disintegrating and mixed effervescent tablet and a preparation method thereof. Background Art

[0002] Dermatitis and eczema are the most common diseases in dermatology, characterized by recurrent eczematous skin lesions and severe itching, often accompanied by comorbidities such as food allergies, asthma, and allergic rhinitis. Currently, most people suffer from dermatitis and eczema, which leads to itching, sleep loss, dietary restrictions, and psychosocial disorders, which seriously affect the quality of life of patients. The pathogenesis of dermatitis and eczema is complex and there is no cure. Although modern medicine has made breakthrough progress in targeted monoclonal antibodies and small molecule antagonists in recent years, it still fails to solve the problems of skin lesion recurrence and itching.

[0003] Traditional Chinese medicine has a unique understanding of dermatitis and eczema. Previous studies have confirmed that traditional Chinese medicine can effectively regulate the activity of immune cells, inhibit the release of inflammatory factors and promote the recovery of skin barrier function. Traditional Chinese medicine compound has a significant therapeutic effect on dermatitis and eczema. However, the traditional method of using topical drugs requires decocting, filtering the liquid medicine, and waiting for the liquid medicine to cool to a suitable temperature for the human body before topical application. This method is time-consuming and labor-intensive. It is inconvenient to use for migrant workers, students, and tourists on business trips. The medicine is large in size and inconvenient to carry. The application occasions are limited, and the medicinal ingredients are not well extracted. It takes multiple decoctions to completely release the effective ingredients. If the twice-decocted medicine is not stored properly, it is easy to mold and damp, and it is difficult to preserve. The extraction efficiency of medicinal materials is poor, and the utilization rate of medicinal materials is low.

[0004] Based on this, the present invention is proposed. Summary of the invention

[0005] The purpose of the present invention is to provide a portable Chinese medicine soaked and rapidly disintegrating effervescent tablet and a preparation method thereof, so as to solve the problems of low drug loading, inconvenient operation during use, easy cross infection, inconvenient carrying and storage, poor component extraction efficiency and low utilization rate existing in traditional water decoctions in the prior art.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The present invention provides an effervescent tablet for treating dermatitis and eczema, comprising the following components in parts by weight:

[0008] 10-40 parts of extract powder, 20-30 parts of citric acid, 15-25 parts of sodium bicarbonate, 1-3 parts of polyvinyl pyrrolidone anhydrous ethanol solution, 1-9 parts of polyethylene glycol 6000, 15-30 parts of lactose and 3-7 parts of sodium carboxymethyl cellulose.

[0009] Preferably, the mass volume ratio of polyvinyl pyrrolidone to anhydrous ethanol in the polyvinyl pyrrolidone anhydrous ethanol solution is 3-7 g:100 mL.

[0010] Preferably, the extract powder comprises the following components in parts by weight:

[0011] 2-4 parts of raw Sanguisorba officinalis, 2-4 parts of Sophora flavescens, 2-4 parts of Phellodendron chinense, 2-4 parts of Portulaca oleracea, 1-3 parts of Atractylodes lancea, and 1-3 parts of Alum.

[0012] Preferably, the method for preparing the extract powder comprises the following steps:

[0013] 1) Mix raw Sanguisorba officinalis, Sophora flavescens, Phellodendron amurense, Portulaca oleracea, Atractylodes lancea and Alum, and grind to obtain ultrafine powder;

[0014] 2) Mix the ultrafine powder with water, reflux and extract for 10 to 20 minutes, and filter to obtain a filtrate;

[0015] 3) concentrating, drying and crushing the filtrate to obtain extract powder;

[0016] The particle size of the crushed particles in step 1) is 350-450 mesh;

[0017] In step 2), the mass ratio of the ultrafine powder to water is 1:4-6, and the temperature of the reflux extraction is 90-110°C;

[0018] The drying method in step 3) is vacuum drying, the drying temperature is 54-62° C., and the crushed particle size is 75-85 mesh.

[0019] The present invention provides a method for preparing the effervescent tablet, comprising the following steps:

[0020] (1) mixing citric acid with 1 / 2 mass parts of extract powder, 1 / 2 mass parts of lactose, and 1 / 2 mass parts of polyvinyl pyrrolidone anhydrous ethanol solution, drying, crushing, and granulating to obtain acid granules;

[0021] (2) mixing sodium bicarbonate with 1 / 2 mass parts of extract powder, 1 / 2 mass parts of lactose, and 1 / 2 mass parts of polyvinyl pyrrolidone anhydrous ethanol solution, drying, crushing, and granulating to obtain alkali particles;

[0022] (3) The acid particles, the alkali particles, polyethylene glycol 6000 and sodium carboxymethyl cellulose are mixed and tableted to obtain an effervescent tablet.

[0023] Preferably, the drying temperatures in step (1) and step (2) are independently 54-62°C.

[0024] Preferably, the drying time in step (1) and step (2) is independently 0.5 to 1.5 hours.

[0025] Preferably, the particle size of the crushed particles in step (1) and step (2) is independently 28 to 32 meshes.

[0026] The present invention has the following technical effects and advantages:

[0027] The present invention provides a portable Chinese medicine soaked fast disintegrating mixed effervescent tablet and a preparation method thereof, which provides a new dosage form of external medicine for the treatment of dermatitis and eczema. First of all, the effervescent tablet has the advantages of dosage form, convenient use, convenient carrying and storage, and stable properties; at the same time, the product has excellent quality, can be quickly disintegrated, has a good mixing effect, and has a good disintegration time and effervescent effect; in addition, the ultrafine powder used to prepare the extract powder can increase the drug wall breaking rate, promote the dissolution of the drug's effective ingredients, improve bioavailability, enhance the efficacy, reduce the amount of medicinal materials under the same effect, and improve resource utilization. The quality inspection, disintegration time limit inspection and hardness inspection of the present invention are all within the scope of national standards, and are also easy to transport, store, carry, and are conducive to industrial production. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 represents the content of active ingredients in medicinal powders with different particle sizes, wherein A represents the content of atractylodesin in medicinal powders with different particle sizes, B represents the content of gallic acid in medicinal powders with different particle sizes, and C represents the content of oxymatrine in medicinal powders with different particle sizes. DETAILED DESCRIPTION

[0029] The present invention provides an effervescent tablet for treating dermatitis and eczema, comprising the following components in parts by weight:

[0030] 10-40 parts of extract powder, 20-30 parts of citric acid, 15-25 parts of sodium bicarbonate, 1-3 parts of polyvinyl pyrrolidone anhydrous ethanol solution, 1-9 parts of polyethylene glycol 6000, 15-30 parts of lactose and 3-7 parts of sodium carboxymethyl cellulose;

[0031] The extract powder is preferably 15 to 30 parts, more preferably 20 parts; the citric acid is preferably 25 parts; the sodium bicarbonate is preferably 20 parts; the polyvinyl pyrrolidone anhydrous ethanol solution is preferably 2 parts; the polyethylene glycol 6000 is preferably 3 to 7 parts, more preferably 5 parts; the lactose is preferably 20 to 30 parts, more preferably 28 parts; the sodium carboxymethyl cellulose is preferably 4 to 6 parts, more preferably 5 parts.

[0032] In the present invention, the mass volume ratio of polyvinyl pyrrolidone to anhydrous ethanol in the polyvinyl pyrrolidone anhydrous ethanol solution is 3-7 g:100 mL, preferably 5 g:100 mL.

[0033] In the present invention, the extract powder comprises the following components in parts by weight:

[0034] 2-4 parts of raw Sanguisorba officinalis, 2-4 parts of Sophora flavescens, 2-4 parts of Phellodendron amurense, 2-4 parts of Portulaca oleracea, 1-3 parts of Atractylodes lancea, and 1-3 parts of Alum;

[0035] The raw Sanguisorba officinalis is preferably 3 parts; the Sophora flavescens is preferably 3 parts; the Phellodendron chinense is preferably 3 parts; the Portulaca oleracea is preferably 3 parts; the Atractylodes lancea is preferably 2 parts; and the Alum is preferably 2 parts.

[0036] In the present invention, the preparation method of the extract powder comprises the following steps:

[0037] 1) Mix raw Sanguisorba officinalis, Sophora flavescens, Phellodendron amurense, Portulaca oleracea, Atractylodes lancea and Alum, and grind to obtain ultrafine powder;

[0038] 2) mixing the ultrafine powder with water, reflux extraction for 10 to 20 minutes, and filtering to obtain a filtrate, wherein the reflux extraction time is preferably 15 minutes, and the filtration method is vacuum filtration;

[0039] 3) concentrating, drying and crushing the filtrate to obtain extract powder, wherein the concentrating method is to place the filtrate in a water bath and concentrate it into a thick paste;

[0040] The particle size of the crushed material in step 1) is 350-450 mesh, preferably 400 mesh;

[0041] In step 2), the mass ratio of the ultrafine powder to water is 1:4-6, preferably 1:5; the temperature of the reflux extraction is 90-110° C., preferably 100° C.;

[0042] The drying method in step 3) is vacuum drying, the drying temperature is 54-62°C, preferably 56-60°C, and more preferably 58°C; the particle size of the crushed product is 75-85 mesh, preferably 80 mesh.

[0043] The present invention provides a method for preparing the effervescent tablet, comprising the following steps:

[0044] (1) mixing citric acid with 1 / 2 mass parts of extract powder, 1 / 2 mass parts of lactose, and 1 / 2 mass parts of polyvinyl pyrrolidone anhydrous ethanol solution, drying, crushing, and granulating to obtain acid granules;

[0045] (2) mixing sodium bicarbonate with 1 / 2 mass parts of extract powder, 1 / 2 mass parts of lactose, and 1 / 2 mass parts of polyvinyl pyrrolidone anhydrous ethanol solution, drying, crushing, and granulating to obtain alkali particles;

[0046] (3) The acid particles, the alkali particles, polyethylene glycol 6000 and sodium carboxymethyl cellulose are mixed and tableted to obtain an effervescent tablet.

[0047] In the present invention, the drying temperatures in step (1) and step (2) are independently 54 to 62°C, preferably 56 to 60°C, and more preferably 58°C.

[0048] In the present invention, the drying time in step (1) and step (2) is independently 0.5 to 1.5 hours, preferably 1 hour.

[0049] In the present invention, the particle size of the pulverized particles in step (1) and step (2) is independently 28 to 32 meshes, preferably 30 meshes.

[0050] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0051] Example 1

[0052] Preparation of extract powder

[0053] 1) Weigh 30g of Radix Sanguisorbae Officinalis, 30g of Sophora flavescens, 30g of Cortex Phellodendri, 30g of Portulaca Oleracea, 20g of Atractylodes macrocephala, and 20g of Alum, place the weighed raw medicine in the grinding disk of a vibration mill, set the rated power to 1.5kW, the speed to 1400rpm, grind for 5min, take out the powder and pass it through a 400-mesh sieve to obtain ultrafine powder;

[0054] 2) Mix the ultrafine powder and water in a mass ratio of 1:5, reflux and extract at 100° C. for 15 min, and filter using a vacuum filter to obtain a filtrate;

[0055] 3) The filtrate was concentrated in a water bath to a thick paste, dried in a vacuum oven at 58°C, and then crushed through an 80-mesh sieve to obtain an extract powder.

[0056] Example 2

[0057] 5 g of polyvinyl pyrrolidone was dissolved in 100 mL of anhydrous ethanol to obtain an anhydrous ethanol solution of polyvinyl pyrrolidone with a concentration of 5%.

[0058] Effervescent tablet formula: 200 g of the extract powder prepared in Example 1, 200 g of citric acid, 200 g of sodium bicarbonate, 20 g of polyvinyl pyrrolidone anhydrous ethanol solution, 50 g of polyethylene glycol 6000, 280 g of lactose and 50 g of sodium carboxymethyl cellulose.

[0059] Preparation method:

[0060] (1) 200 g of citric acid, 100 g of extract powder and 140 g of lactose are mixed, and 10 g of polyvinyl pyrrolidone anhydrous ethanol solution is sprayed to obtain a mixture, the mixture is vacuum dried at 58° C. for 1 h, crushed through a 30-mesh sieve, and then granulated to obtain acid granules;

[0061] (2) 200 g of sodium bicarbonate was mixed with 100 g of extract powder and 140 g of lactose, and 10 g of polyvinyl pyrrolidone anhydrous ethanol solution was sprayed to obtain a mixture, the mixture was dried at 58° C. for 1 h, crushed through a 30-mesh sieve, and then granulated to obtain alkali particles;

[0062] (3) The acid particles, the alkali particles, 50 g of polyethylene glycol 6000, and 50 g of sodium carboxymethyl cellulose are uniformly mixed, and then tableted to obtain an effervescent tablet.

[0063] Example 3

[0064] Effervescent tablet formula: 200 g of the extract powder prepared in Example 1, 250 g of citric acid, 200 g of sodium bicarbonate, 20 g of the polyvinyl pyrrolidone anhydrous ethanol solution prepared in Example 2, 50 g of polyethylene glycol 6000, 280 g of lactose and 50 g of sodium carboxymethyl cellulose.

[0065] The preparation method is the same as that in Example 2.

[0066] Example 4

[0067] Effervescent tablet formula: 200 g of the extract powder prepared in Example 1, 278 g of citric acid, 222 g of sodium bicarbonate, 20 g of the polyvinyl pyrrolidone anhydrous ethanol solution prepared in Example 2, 50 g of polyethylene glycol 6000, 180 g of lactose and 50 g of sodium carboxymethyl cellulose.

[0068] The preparation method is the same as that in Example 2.

[0069] Comparative Example 1

[0070] Weigh 30g of raw Sanguisorba officinalis, 30g of Sophora flavescens, 30g of Phellodendron chinense, 30g of Portulaca oleracea, 20g of Atractylodes macrocephala, and 20g of Alum, place the weighed raw drugs on the grinding disk of the vibration mill, set the rated power to 1.5kW, the speed to 1400rpm, grind for 15s, take out the powder and pass it through an 80-mesh sieve to obtain the powder.

[0071] Comparative Example 2

[0072] Weigh 30 g of raw Sanguisorba officinalis, 30 g of Sophora flavescens, 30 g of Phellodendron chinense, 30 g of Portulaca oleracea, 20 g of Atractylodes macrocephala, and 20 g of Alum, place the weighed raw drugs on the grinding disk of the vibration mill, set the rated power to 1.5 kW, the speed to 1400 rpm, crush for 1.5 min, take out the powder and pass it through a 300-mesh sieve to obtain the powder.

[0073] Test Example 1: Medicinal properties of powders with different particle sizes

[0074] 1. Particle size test

[0075] The particle size distribution of the ultrafine powder obtained in step 1) of Example 1, the drug powder of Comparative Example 1 and Comparative Example 2 was tested by using a laser particle size analyzer. The results are shown in Table 1.

[0076] Table 1 Particle size of different mesh powders

[0077] Mesh 80 mesh (Comparative Example 1) 300 mesh (Comparative Example 2) 400 mesh (Example 1) VMD(μm) 46.04 22.55 18.65

[0078] According to Table 1, the VMD of the ultrafine powder through the 400 mesh sieve of Example 1 is 18.65 μm, the VMD of the powder through the 80 mesh sieve of Comparative Example 1 is 46.04 μm, and the VMD of the powder through the 300 mesh sieve of Comparative Example 2 is 22.55 μm. The VMD of the ultrafine powder through the 400 mesh sieve of the present invention is lower than that of Comparative Examples 1 and 2.

[0079] 2. Determination of active ingredient content

[0080] Take 10g of each of the ultrafine powder obtained in step 1) of Example 1, the powders of Comparative Example 1 and Comparative Example 2, add 50g of deionized water, and boil at 100°C for 15min to obtain water extracts of the powders of Example 1, Comparative Example 1 and Comparative Example 2, respectively. Take 10mL of each of the three water extracts, and use ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry (UPLC-QQQ-MS) to determine the contents of the three effective ingredients of oxymatrine, gallic acid and atractylodesin in the water extracts of the powders of Example 1, Comparative Example 1 and Comparative Example 2. The results are as follows: Figure 1 As shown, A represents the content of atractylodesin in medicinal powders with different particle sizes, B represents the content of gallic acid in medicinal powders with different particle sizes, and C represents the content of oxymatrine in medicinal powders with different particle sizes.

[0081] according to Figure 1 It can be seen that as the particle size decreases, the contents of oxymatrine and gallic acid increase, and the content of atractylodesin first decreases and then increases. When the VMD reaches 18.65 μm, the contents of the three active ingredients are the highest.

[0082] Mix 3g of raw Sanguisorba officinalis, 3g of Sophora flavescens, 3g of Phellodendron amurense, 3g of Portulaca oleracea, 2g of Atractylodes lancea, and 2g of Alum, grind them through a 10-mesh sieve, then add 80mL of deionized water, boil at 100°C for 15min, and obtain the original drug aqueous extract.

[0083] The contents of three active ingredients, namely oxymatrine, atractylodesin and gallic acid, in the original drug and the water extract of the ultrafine powder obtained in step 1) of Example 1 were determined. The results are shown in Table 2.

[0084] Table 2 Active ingredient content in original drug and ultrafine powder water extract

[0085]

[0086] According to Table 2, when the VMD of the ultrafine powder passing through a 400-mesh sieve is 18.65 μm, the content of oxymatrine in the water extract is 295573.70 ng / mL, the content of gallic acid is 84616.06 ng / mL, and the content of atractylodesin is 424.81 ng / mL. The content of oxymatrine in the water extract of the original drug is 261348.44 ng / mL, the content of gallic acid is 65676.10 ng / mL, and the content of atractylodesin is 172.35 ng / mL. The content of oxymatrine in the water extract of the ultrafine powder passing through a 400-mesh sieve is 1.13 times that of the original drug, the content of gallic acid is 1.28 times that of the original drug, and the content of atractylodesin is 2.46 times that of the original drug. It is shown that the ultrafine Chinese medicine powder obtained by the process of the present invention can maximize the content of the effective ingredients in the Chinese medicine compound, and the content is significantly improved compared with the original drug.

[0087] Test Example 2: Performance test of effervescent tablets

[0088] The effervescent tablets of Examples 2 to 4 were used as experimental objects to measure their disintegration time, pH value, and foaming amount, and to observe their appearance and solution clarity. The determination methods of disintegration time, pH value, and foaming amount are as follows:

[0089] Disintegration time determination: Add 200 mL of water to a 250 mL beaker and control the water temperature at 20°C, then add one effervescent tablet. When the gas around the tablet or fragment stops escaping, the tablet should dissolve, and the time when there is no more gas escaping from the solution is the disintegration time of the effervescent tablet.

[0090] pH value determination: Take 2 effervescent tablets, add 25 mL of water, and after the bubbles stop being produced, use a pH meter to determine the pH.

[0091] Determination of foaming amount: Take 10 50mL stoppered graduated test tubes, accurately add 2mL of water to each, place in a 37℃ water bath for 5 minutes, then put one effervescent tablet into each tube, stopper it tightly, and observe the volume of the maximum foaming amount within 20 minutes. The average foaming volume is taken as the foaming amount indicator.

[0092] The test results of the effervescent tablets of Examples 2 to 4 are shown in Table 3.

[0093] Table 3 Performance test of effervescent tablets of Examples 2 to 4

[0094] Grouping Disintegration time / s pH Foaming volume / mL Appearance Solution clarity Example 2 232 4.7 22 smooth Clearer Example 3 160 4.8 24 The smoothest clarify Example 4 150 4.5 21 smooth clarify

[0095] According to the provisions of the Chinese Pharmacopoeia, the disintegration time of the effervescent tablet should be within 5 minutes, and the foaming amount should be more than 6 ml. The pH value is preferably maintained between 4.5 and 5.5, and being in a weakly acidic environment helps promote the healing of the skin barrier. According to Table 3, the various indicators of the three effervescent tablets prepared in Examples 2 to 4 meet the prescribed standards for effervescent tablets in the Chinese Pharmacopoeia. By comparing the disintegration time, pH value, foaming amount, appearance and solution clarity of the effervescent tablets of Examples 2 to 4, it is known that the effervescent tablets obtained by the preparation method of the present invention have the characteristics of short disintegration time, suitable pH, large foaming amount, smooth appearance without cracks, and clear solution after disintegration. Comprehensive comparison, the effervescent tablet prepared in Example 3 has the best performance.

[0096] As can be seen from the above embodiments, the present invention provides a portable Chinese medicine soaked fast disintegrating mixed effervescent tablet and its preparation method. The effervescent tablet prepared according to the method of the present invention has the characteristics of short disintegration time, suitable pH, large foaming volume, smooth appearance without cracks and clear solution after disintegration, breaking the traditional dosage form of existing conventional Chinese medicine for external use. After modern technology processing, the external Chinese medicine for treating dermatitis and eczema is convenient to use, easy to carry and store, and the ingredients are stable. In addition, the ultrafine powder used to prepare the extract powder can increase the drug wall breaking rate, promote the dissolution of the active ingredients of the drug, improve the bioavailability, enhance the efficacy, reduce the amount of medicinal materials under the same effect, and improve the resource utilization rate. The quality inspection, disintegration time limit detection and hardness detection of the present invention are all within the scope of national standards, and are also easy to transport, store, carry, and are conducive to industrial production.

[0097] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. An effervescent tablet for treating dermatitis and eczema, characterized in that: The composition includes the following components in parts by weight: 10-40 parts of extract powder, 20-30 parts of citric acid, 15-25 parts of sodium bicarbonate, 1-3 parts of polyvinyl pyrrolidone anhydrous ethanol solution, 1-9 parts of polyethylene glycol 6000, 15-30 parts of lactose and 3-7 parts of sodium carboxymethyl cellulose.

2. The effervescent tablet according to claim 1, characterized in that The mass volume ratio of polyvinyl pyrrolidone to anhydrous ethanol in the polyvinyl pyrrolidone anhydrous ethanol solution is 3-7 g:100 mL.

3. The effervescent tablet according to claim 1, characterized in that The extract powder includes the following components in parts by weight: 2-4 parts of raw Sanguisorba officinalis, 2-4 parts of Sophora flavescens, 2-4 parts of Phellodendron chinense, 2-4 parts of Portulaca oleracea, 1-3 parts of Atractylodes lancea, and 1-3 parts of Alum.

4. The effervescent tablet according to claim 3, characterized in that The preparation method of the extract powder comprises the following steps: 1) Mix raw Sanguisorba officinalis, Sophora flavescens, Phellodendron amurense, Portulaca oleracea, Atractylodes lancea and Alum, and grind to obtain ultrafine powder; 2) Mix the ultrafine powder with water, reflux and extract for 10 to 20 minutes, and filter to obtain a filtrate; 3) concentrating, drying and crushing the filtrate to obtain extract powder; The particle size of the crushed particles in step 1) is 350-450 mesh; In step 2), the mass ratio of the ultrafine powder to water is 1:4-6, and the temperature of the reflux extraction is 90-110°C; The drying method in step 3) is vacuum drying, the drying temperature is 54-62° C., and the crushed particle size is 75-85 mesh.

5. The method for preparing the effervescent tablet according to any one of claims 1 to 4, characterized in that: The steps include: (1) mixing citric acid with 1 / 2 mass parts of extract powder, 1 / 2 mass parts of lactose, and 1 / 2 mass parts of polyvinyl pyrrolidone anhydrous ethanol solution, drying, crushing, and granulating to obtain acid granules; (2) mixing sodium bicarbonate with 1 / 2 mass parts of extract powder, 1 / 2 mass parts of lactose, and 1 / 2 mass parts of polyvinyl pyrrolidone anhydrous ethanol solution, drying, crushing, and granulating to obtain alkali particles; (3) The acid particles, the alkali particles, polyethylene glycol 6000 and sodium carboxymethyl cellulose are mixed and tableted to obtain an effervescent tablet.

6. The preparation method according to claim 5, characterized in that: The drying temperatures in step (1) and step (2) are independently 54-62°C.

7. The preparation method according to claim 5, characterized in that: The drying time in step (1) and step (2) is independently 0.5 to 1.5 hours.

8. The preparation method according to claim 5, characterized in that: The particle sizes of the pulverized particles in step (1) and step (2) are independently 28 to 32 meshes.

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