An integrated sampling and detection device and its sampler

Abstract

The present invention belongs to the technical field of sampling and testing equipment, and specifically relates to an integrated sampling and detection device and a sampler thereof. The integrated sampling and detection device includes a sampler, a solution tube, a detection tube, and a base. Both ends of the detection tube are provided with openings, and the diameter of the detection tube gradually increases from top to bottom. The sampler includes a holding part, a coupling part, a sampling rod, and a collection part connected in sequence from top to bottom. The interior of the collection part is hollowed out to form an installation space. At least one partition is arranged in the installation space along the width direction of the collection part, and the at least one partition divides the installation space into at least two accommodation cavities. With the above structure, the present application comprehensively provides a self-test device that can stably collect various forms of samples and prevent them from tipping over.

Description

Technical Field

[0001] The present invention belongs to the technical field of sampling and testing equipment, and particularly relates to an integrated sampling and detection device and a sampler thereof. Background Art

[0002] Conventional medical tests (including human and veterinary medicine) sample types mainly include blood, urine, feces, saliva, vaginal secretions, etc. Among them, fecal detection, as a non-invasive detection method, is simple and easy to obtain. During the fecal detection process, it is usually necessary to use a collection spoon / sampling rod to collect feces samples, and then put the collection spoon / rod after collecting the samples into a disposable storage tube body that matches it, and seal it for subsequent detection operations.

[0003] For example, the Chinese invention patent with the application number 2017103195448 discloses an independent fecal sampling head, which includes a main body. The main body has a spiked part and a brush part. One end of the spiked part is a pointed structure, and the other end of the spiked part is connected to one end of the brush part; the circumferential direction of the brush part has bristles, and a storage area is formed between the bristles and the other end of the spiked part as a place to store the collected samples.

[0004] The above sampling head can basically achieve the collection of samples. However, for samples with different properties, including liquid, solid, and viscous samples, it is difficult for the above sampling head to ensure the sampling volume. Moreover, especially for feces, its collection, preservation, and transportation requirements are relatively high. Some detection indicators are less stable in feces and need to be freshly collected. However, people who go to the hospital for physical examinations do not have the urge to defecate or it is not easy to defecate in the hospital environment, resulting in low coverage and participation rates for many detections, and they cannot be detected in time, which may delay the progress of the disease.

[0005] Therefore, the Chinese invention patent with the publication number CN117129671A discloses an integrated fecal sample collection and detection device, which includes a detection bottle and a sampling rod; the detection bottle is a three-layer nested structure connected by a card slot, from the inside to the outside are a sample treatment liquid bottle, a test paper holder, and an outer bottle; for another example, the Chinese utility model patent with the publication number CN220795049U discloses an integrated detection tube, including: a sampling rod, the sampling rod includes a hand-held part for holding and a sampling tube for sampling, and the hand-held part is connected to the sampling tube; a container tube, the container tube has openings at both ends and is hollow inside, and the sampling tube of the sampling rod is embedded in the container tube; a collection cavity, a guiding groove is arranged in the collection cavity, and at least part of the container tube is embedded in the collection cavity; wherein, an aluminum foil is arranged at the opening at one end of the container tube away from the hand-held part.

[0006] The above-mentioned devices are all composed of multiple straight tube components "nested layer by layer" from top to bottom, and their stability is difficult to guarantee. In order to prevent tipping, the existing technology usually increases its stability by additional independent auxiliary components, such as counterweight structures, clamping structures, adsorption devices, etc. However, the above methods will inevitably increase the complexity of the equipment.

[0007] Therefore, there is an urgent need for a sampling and detection device with a simple structure, good sampling effect, and both stability and sealing. Summary of the Invention

[0008] The object of the present invention is to provide an integrated sampling and detection device and a sampler thereof, so as to partially alleviate or solve the above-mentioned problems.

[0009] In order to solve the above-mentioned technical problems, the present invention specifically adopts the following technical solutions:

[0010] The present application provides an integrated sampling and detection device, comprising: a sampler, a solution tube, a detection tube, and a base; both ends of the detection tube are provided with openings, and the diameter of the detection tube gradually increases from the top to the bottom; at least a portion of the solution tube is sleeved within the detection tube, at least a portion of the sampler is sleeved within the solution tube, and the base cooperates with the opening at the bottom of the detection tube;

[0011] The base includes a bottom cover, and an enclosure and a puncture portion arranged on the bottom cover, the outer wall of the enclosure fits with the inner wall of the detection tube, the puncture portion is located in the enclosure space formed by the enclosure, and the inner diameter of the top of the enclosure decreases from top to bottom, so that the top of the enclosure forms a transition slope; a slot is provided on one side of the enclosure, and a detection space for accommodating a test strip is provided on the detection tube, and an opening connected to the slot is provided at the bottom of the detection space, so that the first end of the test strip can extend from the opening and pass through the slot into the enclosure space.

[0012] As an improvement, the enclosure includes a first baffle and a second baffle arranged in sequence from the outside to the inside, the height of the second baffle is lower than the height of the first baffle, the first end of the first baffle is connected to the first end of the second baffle through a third baffle, and the transition slope is formed on the first surface of the third baffle; the outer wall of the first baffle is in contact with the inner wall of the detection tube; the first baffle, the second baffle, the third baffle and the bottom cover enclose a cavity.

[0013] As an improvement, the side of the enclosure close to the opening is recessed downward along its height direction to form the slot, and the parts of the enclosure located on both sides of the slot are respectively recessed inward to form slots communicating with the enclosure space, and the slots are arranged along the height direction of the enclosure;

[0014] When the first end of the test strip is extended out of the opening hole and the first end of the test strip is inserted into the enclosure space along the card slot, both sides of the first end of the test strip are clamped into the card slot for fixation.

[0015] As an improvement, the solution tube includes an integrally formed bottom plate and a tube body. The bottom plate is arranged at the bottom of the tube body, and an opening cooperating with the sampler is arranged at the top of the solution tube; a puncture groove cooperating with the tip of the puncture part is arranged on the bottom plate, and the thickness of the puncture groove is less than the thickness of the bottom plate.

[0016] As an improvement, a sample scraping structure is arranged inside the solution tube. The sample scraping structure includes a solution exchange area, a collection area and a sample scraping area which are arranged in sequence from top to bottom. At least one exchange hole is arranged in the solution exchange area, and at least two sample scraping protrusions are arranged in the sample scraping area. A sample scraping groove is formed between two adjacent sample scraping protrusions;

[0017] The inner diameters of the exchange area and the collection area gradually decrease from top to bottom, and the inner diameter of the sample scraping area is the same along the height direction of the solution tube, so that the sample scraping structure is in a funnel shape.

[0018] The present application also provides a sampler, including: a holding part, a combining part, a sampling rod and a collection part which are connected in sequence from top to bottom. The inside of the collection part is hollowed out to form an installation space. At least one partition plate is arranged in the installation space along the width direction of the collection part, and the at least one partition plate divides the installation space into at least two accommodation cavities; a pointed structure is arranged at the first end of the collection part, and the pointed structure includes a first surface, a second surface, a third surface and a fourth surface which are connected in sequence. The first surface, the second surface, the third surface and the fourth surface are arranged circumferentially along the pointed structure; wherein, the first surface and the third surface respectively recess inwards to form a guiding area with a first inclination degree.

[0019] As an improvement, a plurality of anti-slip protrusions and / or a plurality of recessed parts are arranged on the partition plate, and adjacent anti-slip protrusions cooperate with the partition plate to form a limiting structure, so as to divide the accommodation cavity into a plurality of accommodation areas.

[0020] As an improvement, a plurality of partition plates are arranged, and the plurality of partition plates are uniformly arranged in the installation space, so that the heights of the plurality of accommodation cavities are the same.

[0021] As an improvement, a plurality of partition plates are arranged, and the plurality of partition plates are non-uniformly arranged in the installation space to form a plurality of accommodation cavities with different heights.

[0022] As an improvement, the second end of the installation space extends towards the second end of the collection part to form a transition area with a second inclination.

[0023] The principle and beneficial technical effects of the present invention are as follows:

[0024] Completely different from the way of "nested layer by layer" from top to bottom using multiple straight tube components in the prior art, the present application provides a semi-wrapped anti-tipping device installed from bottom to top with the test strip inside. The device with the above structure has greatly improved stability, simple structure and convenient installation.

[0025] First of all, by concentrating the center of gravity of the self-test device at the bottom of the device, the present application can largely prevent tipping. Moreover, the test strip in the test tube is directly introduced into the enclosure space during the installation process and directly contacts the solution dissolved with the sample in the enclosure space, and the solution does not need to enter the test tube or the gap between the test tube and the enclosure. That is to say, in the non-tipping state, the solution is always located in the enclosure space, thus avoiding the leakage of the solution from the gap between the test tube and the enclosure; specifically, the base and the test tube in the present application are both designed in a frustum shape, and the base is matched with the test tube through the opening at the bottom of the test tube. It adopts an "installation method from bottom to top", and the installed base is located in the lower half of the test tube, which is convenient and fast to install; that is to say, the present application provides a sampling and detection integrated device with simple installation, greatly improved stability while preventing liquid leakage.

[0026] Furthermore, even if tipping occurs, the enclosure is closely arranged against the inner wall of the test tube, and a transition inclined plane is arranged at the top of the enclosure and further sealed through the limiting structure at its bottom, so that the solution is difficult to leak out of the test tube. And after the self-test device is righted, the solution above the enclosure can quickly flow back into the enclosure space under the guiding action of the transition inclined plane, further avoiding the occurrence of liquid leakage.

[0027] Even further, for samples with different volumes / quantities, the present application provides a solution that can "quantitatively" dissolve the sample into the solution. Specifically, by adjusting the height of the sample scraping structure, excessive samples are excluded from the solution, and a smaller sample volume can be dissolved in the solution as much as possible. That is to say, whether it is a sample with a larger volume (such as feces) or a sample with a smaller quantity and / or volume (such as virus), the present device can stably collect and detect it, thus ensuring the reliability of the detection result.

[0028] In addition, in view of the sampling requirements for samples of different forms, the present application comprehensively provides a sampler with a "guided semi-closed accommodating cavity". By arranging a plurality of "semi-closed" accommodating cavities in the collection part and respectively arranging guiding structures on both sides of the collection part, it is possible to collect and stably store samples of different forms, and to a certain extent prevent the problem of samples falling off the sampler. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to actual scale. Obviously, the following-described drawings are some embodiments of the present invention. For those of ordinary skill in the art, without creative effort, other drawings can also be obtained based on these drawings.

[0030] Figure 1 It is a three-dimensional view of the integrated sampling and detection device in the initial state in the embodiment of the present invention;

[0031] Figure 2 It is a three-dimensional view of the integrated sampling and detection device in the detection state in the embodiment of the present invention;

[0032] Figure 3 It is an exploded view of the integrated sampling and detection device in the embodiment of the present invention;

[0033] Figure 4 It is a cross-sectional view of the integrated sampling and detection device in the initial state in the embodiment of the present invention;

[0034] Figure 5 It is an enlarged schematic view of part B of the integrated sampling and detection device in the embodiment of the present invention;

[0035] Figure 6 It is a cross-sectional view of the integrated sampling and detection device from another angle in the initial state in the embodiment of the present invention;

[0036] Figure 7 It is a cross-sectional view of the integrated sampling and detection device when sampling in the embodiment of the present invention;

[0037] Figure 8 It is a cross-sectional view of the integrated sampling and detection device after sampling and inserting the sampler back into the solution tube in the embodiment of the present invention;

[0038] Figure 9 It is a cross-sectional view of the integrated sampling and detection device after removing the limiting member in the embodiment of the present invention;

[0039] Figure 10Cross-sectional view during the detection process after the solution tube and the sampler are pressed down in the integrated sampling and detection device according to the embodiment of the present invention;

[0040] Figure 11 Stereogram of the base in the embodiment of the present invention;

[0041] Figure 12 Front view of the sampler in the embodiment of the present invention;

[0042] Figure 13 Side view of the sampler in the embodiment of the present invention;

[0043] Figure 14 Stereogram of the sampler in the embodiment of the present invention;

[0044] Figure 15 For Figure 12 Enlarged schematic view of part A in;

[0045] Figure 16 An example of the sampler size in the embodiment of the present invention;

[0046] Figure 17 An example of the sampler size in the embodiment of the present invention;

[0047] Figure 18 Stereogram of the solution tube in the embodiment of the present invention;

[0048] Figure 19 Top view of the partition in the embodiment of the present invention;

[0049] Figure 20 Schematic diagram of the detection tube in the embodiment of the present invention;

[0050] Figure 21 Schematic diagram of the sampling rod in the fourth embodiment of the present invention;

[0051] Figure 22 Schematic diagram of the upper cover in the fourth embodiment of the present invention;

[0052] Figure 23 Schematic diagram of the scraping structure in the fifth embodiment of the present invention;

[0053] Figure 24 Cross-sectional view of the integrated sampling and detection device in the initial state in the fifth embodiment of the present invention;

[0054] Figure 25 Cross-sectional view of the integrated sampling and detection device during sampling in the fifth embodiment of the present invention;

[0055] Figure 26 Cross-sectional view when the scraping structure is above the liquid level in the fifth embodiment of the present invention;

[0056] Figure 27 Schematic diagram of another form of scraping sample structure in the fifth embodiment of the present invention.

[0057] Markings in the figure: 1. Sampler; 11. Holding part; 111. Anti-slip groove; 12. Coupling part; 13. Sampling rod; 131. First groove; 132. Second groove; 14. Collection part; 141. Pointed structure; 142. Guiding area; 143. Transition area; 144. Partition; 401. Anti-slip protrusion; 402. Accommodating area; 145. Accommodating cavity; 2. Solution tube; 21. Bottom plate; 211. Puncture groove; 22. Tube body; 23. Guiding part; 24. Anti-slip strip; 25. Storage groove; 26. Solution; 3. Detection tube; 31. Detection space; 32. Opening; 33. Test strip mounting groove; 34. Limiting step; 4. Base; 41. Bottom cover; 42. Enclosure; 421. First baffle; 422. Second baffle; 423. Third baffle; 424. Cavity; 425. Card slot; 43. Puncture part; 44. Transition slope; 45. Groove; 46. Enclosure space; 47. Limiting protrusion; 5. Limiting part; 6. Test strip; 7. Fixing part; 71. Display hole; 8. Protection plate; 9. Sealing ring; 10. Upper cover; 20. Scraping sample structure; 201. Solution exchange area; 202. Collection area; 203. Scraping sample area; 204. Scraping protrusion; 205. Scraping groove; 206. Exchange hole; 207. Support part; 208. Through hole. Detailed implementation manners

[0058] To make the objectives, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Apparently, the described embodiments are some but not all of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0059] In this article, suffixes such as "module", "component" or "unit" used to represent elements are only for the convenience of describing the present invention, and have no specific meaning in themselves. Therefore, "module", "component" or "unit" can be used interchangeably. In this article, terms such as "upper", "lower", "inner", "outer", "front", "rear", "one end", "the other end", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be construed as a limitation of the present invention. In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0060] In this text, unless otherwise clearly stipulated and defined, terms such as "installation", "equipped with", "connection", etc. shall be understood in a broad sense. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, a direct connection, or an indirect connection through an intermediate medium, and can also be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances. In this text, "a plurality" means two or more, that is, it includes two, three, four, five, etc.

[0061] Embodiment 1

[0062] This embodiment is basically as shown in the appended Figures 12 - 17 and Figure 19 figures:

[0063] This embodiment provides a sampler. Refer to Figure 12 and Figure 13 , which includes a holding part 11, a coupling part 12, a sampling rod 13, and a collection part 14 that are connected in sequence from top to bottom.

[0064] Refer to Figure 15 , the interior of the collection part is hollowed out to form an installation space. At least one partition 144 is arranged in the installation space along the width direction of the collection part. The at least one partition 144 divides the installation space into at least two accommodation cavities 145; a pointed structure 141 is arranged at the first end of the collection part. The pointed structure 141 includes a first surface, a second surface, a third surface, and a fourth surface that are connected in sequence. The first surface, the second surface, the third surface, and the fourth surface are arranged along the circumferential direction of the pointed structure 141; wherein, the first surface and the third surface respectively recess inward to form a guiding area 142 with a first inclination.

[0065] In some embodiments, the first surface and the third surface are oppositely arranged, and the second surface and the fourth surface are oppositely arranged. That is to say, two of the sides of the pointed structure form a bevel shape after cutting (i.e., the guiding area 142), so that the width of the pointed structure increases sequentially from bottom to top, and then smoothly transitions to the installation space. Thus, when the sampler is inserted into the sample, the sample can enter the accommodation cavity along the guiding area.

[0066] In some embodiments, the middle part of the cross-section of the installation space is rectangular, and the two width sides of the rectangle extend towards both ends to form an arc shape.

[0067] In some embodiments, the tip part of the pointed structure is a blunt end.

[0068] Refer to Figure 19, a plurality of anti-slip protrusions 401 and / or a plurality of recessed portions are provided on the partition plate. Adjacent anti-slip protrusions 401 and the partition plate cooperate to form a limiting structure, thereby dividing the accommodation cavity into a plurality of accommodation areas 402. Through the cooperation of the anti-slip protrusions and the surface of the partition plate, when the sample enters the accommodation area, the adjacent anti-slip protrusions cooperate to limit the sample in the width direction (radial direction), and the adjacent two partition plates limit the sample in the height direction, so that the sample can be stably stored inside the accommodation area.

[0069] In some embodiments, a plurality of partition plates are provided, and the plurality of partition plates are evenly arranged in the installation space, so that the heights of the plurality of accommodation cavities are the same.

[0070] In other embodiments, a plurality of partition plates are provided, and the plurality of partition plates are unevenly arranged in the installation space to form a plurality of accommodation cavities with different heights.

[0071] In some embodiments, the partition plate is a circular partition plate, the sampling rod is a cylindrical shape, and the diameter of the partition plate is less than or equal to the diameter of the sampling rod.

[0072] In some embodiments, the second end of the installation space extends towards the second end of the collection part to form a transition area 143 with a second inclination.

[0073] In some embodiments, two guiding areas and the transition area 143 are both provided, and they are axisymmetric about the center of the sampling rod.

[0074] In some embodiments, see Figure 14 , a first groove 131 and a second groove 132 are circumferentially provided on the sampling rod, and sealing rings are provided in both the first groove 131 and the second groove 132.

[0075] In some embodiments, see Figure 14 , the holding part is spherical, and the inner diameter of the holding part gradually increases and then decreases from the first end to the second end, and a plurality of anti-slip grooves 111 are circumferentially provided on the holding part.

[0076] In some specific embodiments, the anti-slip grooves are a plurality of grooves formed by the surface of the spherical holding part being recessed inward in the width direction.

[0077] In some embodiments, the plurality of grooves are evenly distributed on the spherical holding part.

[0078] By setting a spherical holding part, it is convenient for the user to apply force when pressing the holding part and pulling out the sampler from the self-test device. In addition, the holding part adopts a hollow structure (anti-slip groove). On the one hand, it can save production costs. On the other hand, it can reduce the weight of the holding part and prevent the sampler from being "top-heavy" and tipping over when cooperating with the self-test device.

[0079] In some embodiments, the volume of the installation space is 50mm 3 -200mm 3 (preferably 73mm 3 ).

[0080] Exemplarily, referring to Figure 16 and Figure 17 , an example of a sampler is given in the figure. Specifically, the total length of the sampler is 90.1mm, the width of the joint part is 15mm, the height of the holding part and the joint part is 37.7mm, the height of the collection part is 18.3mm, the height of the installation space is 11.8mm, the number of accommodation cavities is 6, the height of 5 accommodation cavities is 1.1mm, and the height of the other accommodation cavity is 2.25mm; the width of the sampling rod is 3.9mm, and the width of the collection part is 3.7mm.

[0081] In summary, the present application can collect and stably store samples of different forms by setting a plurality of "semi-closed" accommodation cavities in the collection part and respectively arranging guiding structures on both sides of the collection part, and can prevent the problem of samples falling off the sampler to a certain extent.

[0082] First, the accommodation cavity in the present application is formed by enclosing the inner wall of the installation space (i.e., the side wall of the collection part) and the partition board. During use, the two side walls of the collection part can limit the sample in the accommodation cavity in the width direction, and adjacent two partition boards, or a partition board and the bottom wall or top wall of the installation space can limit the sample in the accommodation cavity in the height direction, so that the sample is in a "semi-closed" space. And after sampling, and during the process of inserting the sampler into the self-test device, the sampler always maintains an upright state. Thus, by synchronously limiting the sample in the width and height directions through the above structure, it can effectively prevent the sample from falling out of the accommodation cavity.

[0083] Furthermore, by respectively arranging "guiding structures" on both sides of the collection part, it can enable the sampler to collect as many samples as possible during the process of inserting and pulling out the sample; specifically, a guiding area is set on the pointed structure at the first end of the collection part. During the process of inserting the sampler into the sample, the sample can enter the accommodation cavity along the guiding area. At the same time, during the process of pulling out the sampler from the sample, due to the resistance of the sample, the sample above the accommodation cavity can enter the accommodation cavity along the transition area.

[0084] Furthermore, for different samples, partitions with uniform or non-uniform settings can be selected respectively. For example, for liquid feces samples, partitions with uniform settings can be selected. In this way, the samples can enter the accommodation cavity evenly. Further, the density of the partitions can be increased, that is, the interval between the partitions can be reduced, so that the height of the accommodation cavity is lower and it is easier to store samples. For solid feces samples, partitions with non-uniform settings can be selected. In this way, accommodation spaces at different heights can collect solid feces with different particle sizes respectively, and samples with different particle sizes can be respectively stuck into different accommodation spaces.

[0085] Embodiment 2

[0086] This embodiment provides a self-test device, see Figure 1 and Figure 20 , including a solution tube 2, a detection tube 3 and a base 4.

[0087] Both ends of the detection tube are provided with openings, and the diameter of the detection tube gradually increases from top to bottom, that is, the cross-sectional shape of the detection tube is trapezoidal. At least a part of the solution tube is sleeved inside the detection tube, and the base is matched with the opening at the bottom of the detection tube.

[0088] In some embodiments, the diameter of the part of the solution tube extending into the detection tube is smaller than the inner diameter of the opening at the top of the detection tube, so that the solution tube can extend into the detection tube from the top of the solution tube, and the base is installed at the bottom of the detection tube from the opening at the bottom of the detection tube.

[0089] In some embodiments, see Figure 5 , a limiting protrusion 47 is provided at the bottom of the base, and a limiting step 34 is provided at the bottom of the detection tube. When the base is installed inside the detection tube, the limiting protrusion 47 abuts against the limiting step 34, thereby limiting the base and further ensuring the sealing between the two to prevent the solution from leaking out from the connection between the two.

[0090] See Figure 4 , Figure 5 and Figure 11, the base includes a bottom cover 41, as well as a retaining wall 42 and a puncturing part 43 provided on the bottom cover. The outer wall of the retaining wall 42 fits against the inner wall of the test tube, that is, the base is also trapezoidal in structure. The puncturing part 43 is located within the retaining space 46 formed by the retaining wall 42. The inner diameter of the top of the retaining wall 42 decreases sequentially from top to bottom, so that a transition slope 44 is formed at the top of the retaining wall 42. A slot 45 is provided on one side of the retaining wall. A test space 31 for accommodating a test strip is provided on the test tube. An opening 32 communicating with the slot 45 is provided at the bottom of the test space 31, so that the first end of the test strip can extend out from the opening 32 and pass through the slot 45 into the retaining space 46.

[0091] In some embodiments, the height of the retaining wall is less than the height of the test tube, and the top of the retaining wall is located in the lower half of the test tube.

[0092] Compared with the straight tube structure in the prior art and the installation method of "nested layer by layer" from top to bottom, the present application provides an anti-tipping self-test device by providing a frustum-shaped test tube and adopting a "semi-wrapping" cooperation method of the test tube and the base from bottom to top.

[0093] Specifically, the base is matched with the test tube through the opening at the bottom of the test tube, and the installation method of "from bottom to top" is adopted, so that the installed base is located in the lower half of the test tube. On the one hand, it can make the center of gravity of the self-test device concentrated at the bottom of the device. Cooperating with the frustum-shaped test tube, it can prevent tipping to a certain extent. On the other hand, the test strip in the test tube can be directly introduced into the retaining space during the installation process, which is convenient and fast, and there is no need to install an additional test strip accommodating structure.

[0094] Furthermore, a transition slope is provided at the top of the retaining wall. Even if tipping occurs, since the retaining wall is closely attached to the inner wall of the test tube, the solution is difficult to leak out of the test tube. After the self-test device is righted, the solution above the retaining wall can flow back into the retaining space through the transition slope, further avoiding the situation of liquid leakage.

[0095] In some embodiments, see Figure 4 , the retaining wall includes a first retaining piece 421 and a second retaining piece 422 arranged in sequence from outside to inside. The height of the second retaining piece 422 is lower than the height of the first retaining piece 421. The first end of the first retaining piece 421 is connected to the first end of the second retaining piece 422 through a third retaining piece 423, and the transition slope is formed on the first surface of the third retaining piece 423. The outer wall of the first retaining piece 421 fits against the inner wall of the test tube 3. The first retaining piece 421, the second retaining piece 422, the third retaining piece 423 and the bottom cover enclose a cavity 424.

[0096] In some embodiments, referring to Figure 11 , on one side of the retaining wall 42 close to the opening, a slot 45 is formed by being recessed downward along the height direction thereof. On both sides of the slot of the retaining wall 42, parts are respectively recessed inward to form clamping slots 425 communicating with the retaining wall space. The slot 45 is arranged along the height direction of the retaining wall 42;

[0097] When the first end of the test strip is extended out from the opening and the first end of the test strip is extended into the retaining wall space along the slot, both sides of the first end of the test strip are clamped and fixed in the clamping slots; wherein, the first end of the test strip refers to the end of the test strip that contacts the liquid.

[0098] Fixing the first end of the test strip through the clamping slots can prevent the test strip from warping after being bent by the opening and slot structures, so that the end of the test strip is always located at the bottom of the retaining wall space to realize liquid absorption.

[0099] In some embodiments, referring to Figure 5 , the solution tube includes an integrally formed bottom plate 21 and a tube body. The bottom plate is arranged at the bottom of the tube body, and an opening is arranged at the top of the solution tube.

[0100] In some embodiments, a puncture groove 211 is arranged on the bottom plate 21 and is matched with the tip of the puncture part. The thickness of the puncture groove 211 is smaller than the thickness of the bottom plate 21.

[0101] In some embodiments, the solution tube is made of plastic.

[0102] Compared with the solution tube with upper and lower openings in the prior art, and then an aluminum film is arranged at the bottom of the solution tube to achieve sealing, in the present application, by designing an integrally formed solution tube with a puncture groove, the production process can be simplified, the cost can be reduced, and the puncture difficulty will not be increased. During the puncture process, the bottom of the solution tube is broken along the puncture groove. That is to say, the solution enters the retaining wall space through the crack formed after the puncture groove cracks, which can avoid large particles in the solution from entering the retaining wall space and directly contacting the test strip, thereby causing the problem of inaccurate measurement results.

[0103] In some embodiments, the limiting member is detachably arranged outside the solution tube. In some specific embodiments, the limiting member includes an elastic snap ring with an open end and a pull ring located on the opposite side of the opening. During use, when the snap ring is clamped on the solution tube, the height of the solution tube can be limited to prevent the bottom plate at the bottom of the solution tube from contacting the puncture part and being punctured; when the pull ring is pulled to remove the snap ring from the solution tube and the solution tube is pressed downward, the bottom plate can be made to contact the puncture part and be punctured by it.

[0104] In some embodiments, referring to Figure 3, a display area is provided on the detection tube. Inside the display area, a test strip mounting groove 33 is provided along the height direction of the detection tube. The test strip mounting groove 33 communicates with the opening. The test strip is fixed in the test strip mounting groove by a fixing member 7. A display hole 71 is provided on the fixing member, and a transparent protection plate 8 is further provided outside the fixing member.

[0105] In some embodiments, referring to Figure 18 , a guiding portion 23 is provided on the outer wall of the solution tube. The outer diameter of the guiding portion 23 gradually increases from its first end to its second end, and the first end of the guiding portion 23 is smoothly transitioned with the solution tube. Herein, the first end is the end of the guiding portion close to the bottom plate of the solution tube, and the second end is the end of the guiding portion close to the opening of the solution tube. By providing the guiding portion, it can make the process of pressing down the solution tube more effortless and avoid jamming.

[0106] In some embodiments, a plurality of anti-slip strips 24 are formed by extending the second end of the guiding portion along the height direction of the solution tube.

[0107] In some embodiments, a storage groove 25 is formed by extending the top of the solution tube upward. The cross-sectional shape of the storage groove is an inverted trapezoid. By providing the inverted trapezoid storage groove, on the one hand, it can play a guiding role when inserting the sampler into the solution tube, and on the other hand, this structure can collect the excess sample. Specifically, during the user's operation, the user usually holds the detection tube with one hand and holds the holding portion with the other hand to insert the sampler back into the detection tube. During this process, the sample may drip from the sampler, and the storage groove can collect the dripping sample to prevent the sample from dripping onto the user's hand.

[0108] In some embodiments, the storage groove and the solution tube are integrally formed. In some specific embodiments, the storage groove is made of plastic.

[0109] In summary, in this embodiment, by providing a frustum-shaped detection tube and adopting a "semi-wrapping" cooperation method between the detection tube and the base, an anti-tipping self-test device is comprehensively provided.

[0110] Embodiment III

[0111] This embodiment is basically as shown in the appendix Figures 1 - 20 as follows:

[0112] This embodiment provides a sampling and detection integrated device, including a sampler 1 and a self-test device. The self-test device includes a solution tube 2, a detection tube 3, and a base 4. Among them, the structure of the sampler 1 can refer to the sampler 1 structure in Embodiment I, and the structure of the self-test device can adopt the structure of the self-test device in Embodiment II.

[0113] In some embodiments, the integrated sampling and detection device includes: a sampler 1, a solution tube 2, a detection tube 3, and a base 4; both ends of the detection tube 3 are provided with openings, and the diameter of the detection tube 3 gradually increases from top to bottom. At least a part of the solution tube 2 is sleeved inside the detection tube 3, at least a part of the sampler 1 is sleeved inside the solution tube 2, and the base 4 is matched with the opening at the bottom of the detection tube 3;

[0114] The base 4 includes a bottom cover 41, and a retaining wall and a puncture part 43 provided on the bottom cover 41. The outer wall of the retaining wall fits with the inner wall of the detection tube 3. The puncture part 43 is located in a retaining space 46 formed by the retaining wall. The inner diameter of the top of the retaining wall gradually decreases from top to bottom, so that a transition slope 44 is formed at the top of the retaining wall; a slot 45 is provided on one side of the retaining wall. A detection space 31 for accommodating a test strip is provided on the detection tube 3, and an opening 32 communicating with the slot 45 is provided at the bottom of the detection space 31, so that the first end of the test strip can extend out from the opening 32 and pass through the slot 45 into the retaining space 46.

[0115] In some embodiments, the retaining wall includes a first retaining piece 421 and a second retaining piece 422 arranged in sequence from outside to inside. The height of the second retaining piece 422 is lower than that of the first retaining piece 421. The first end of the first retaining piece 421 is connected to the first end of the second retaining piece 422 through a third retaining piece 423, and the transition slope 44 is formed on the first surface of the third retaining piece 423; the outer wall of the first retaining piece 421 fits with the inner wall of the detection tube 3; the first retaining piece 421, the second retaining piece 422, the third retaining piece 423, and the bottom cover 41 enclose to form a cavity 424.

[0116] In some embodiments, the retaining wall is recessed downward along its height direction on the side close to the opening 32 to form the slot 45. The parts of the retaining wall on both sides of the slot 45 are respectively recessed inward to form a card slot 425 communicating with the retaining space 46. The card slot 425 is arranged along the height direction of the retaining wall; when the first end of the test strip is extended out from the opening 32 and the first end of the test strip is extended into the retaining space 46 along the card slot 425, both sides of the first end of the test strip are clamped into the card slot 425 for fixation.

[0117] In some embodiments, the solution tube 2 includes a bottom plate 21 and a tube body 22 integrally formed. The bottom plate 21 is arranged at the bottom of the tube body 22, and an opening for cooperating with the sampler 1 is provided at the top of the solution tube 2.

[0118] In some embodiments, an installation part with a first inner diameter and a solution chamber with a second inner diameter are sequentially arranged inside the solution tube from top to bottom. When the sampler is inserted into the solution chamber, the joint part of the sampler is located inside the installation part, and the collection part is located inside the solution chamber.

[0119] In some embodiments, a puncture groove 211 that cooperates with the tip of the puncture part 43 is provided on the bottom plate 21, and the thickness of the puncture groove 211 is less than the thickness of the bottom plate 21.

[0120] When this device is specifically used, refer to Figures 6 - 10 , Figure 6 which shows a schematic diagram of the device in its initial state. When in use, first hold the holding part, pull out the sampler from the solution tube, and then insert the collection part of the sampler into the sample to achieve sampling (refer to Figure 7 ), and then insert the sampler back into the solution tube so that the sample in the collection part contacts the solution in the solution tube (refer to Figure 8 ); then remove the limiting part located on the solution tube (refer to Figure 9 ), press the holding part downward so that the holding part drives the solution tube to move downward, and then the bottom plate at the bottom of the solution tube contacts and is punctured by the tip part of the puncture part (refer to Figure 10 ). The liquid with the sample dissolved in the solution tube passes through the gap formed by the puncture groove part of the bottom plate and flows into the enclosure space to contact the first end of the test strip, and finally the running plate is realized, and the test result is displayed in the display area outside the solution tube. During this process, the liquid level of the solution in the enclosure is always below the opening, that is to say, in the normal upright state, the solution will not enter the test tube, thus avoiding solution leakage.

[0121] The integrated fecal sampling and detection device with the above structure provides an anti-tipping self-test device by setting a frustum-shaped test tube, and the test tube and the base adopt a "semi-wrapping" matching method, and by setting a "semi-hollow" holding part.

[0122] Specifically, the base is matched with the test tube through the opening at the bottom of the test tube, and is installed in a "from bottom to top" installation method, so that the installed base is located in the lower half of the test tube. On the one hand, it can make the center of gravity of the self-test device concentrate at the bottom of the device, and cooperate with the frustum-shaped test tube to prevent tipping to a certain extent. On the other hand, the test strip located in the test tube can be directly introduced into the enclosure space during the installation process, which is convenient and fast, and there is no need to install an additional test strip accommodating structure.

[0123] Furthermore, a transition slope is provided at the top of the enclosure. Even if the enclosure topples over, since the enclosure is closely attached to the inner wall of the test tube, it is difficult for the solution to leak out of the test tube. After the self-test device is righted, the solution above the enclosure can flow back into the enclosure space through the transition slope, further preventing liquid leakage.

[0124] Furthermore, by providing a spherical holding part, it is convenient for the user to apply force when pressing the holding part and when pulling out the sampler from the self-test device. In addition, the holding part adopts a hollow structure (anti-slip groove). On the one hand, it can save production costs, and on the other hand, it can reduce the weight of the holding part, preventing the sampler from being "top-heavy" and toppling over when cooperating with the self-test device.

[0125] Embodiment 4

[0126] Different from Embodiment 3, refer to Figure 21 , in this embodiment, the sampler 1 is an independent sampling structure, such as a swab; refer to Figure 22 , the self-test device further includes an independent upper cover 10, the upper cover 10 is detachably arranged in the opening at the top of the solution tube, and the upper cover 10 is used to cooperate with the solution tube to seal the solution inside the solution tube within the solution tube.

[0127] In some embodiments, the upper cover 10 includes a holding part 11 and a coupling part 12 connected in sequence from top to bottom.

[0128] In some embodiments, refer to Figure 14 , the holding part is spherical, and the inner diameter of the holding part gradually increases and then decreases from the first end to the second end, and a plurality of anti-slip grooves 111 are circumferentially arranged on the holding part.

[0129] In some specific embodiments, the anti-slip grooves are a plurality of grooves formed by the surface of the spherical holding part being recessed inward along the width direction.

[0130] In some embodiments, the plurality of grooves are evenly distributed on the spherical holding part.

[0131] In some embodiments, a sealing ring 9 is provided on the coupling part 12.

[0132] By providing a spherical holding part, it is convenient for the user to apply force when pressing the holding part and when pulling out the sampler from the self-test device. In addition, the holding part adopts a hollow structure (anti-slip groove). On the one hand, it can save production costs, and on the other hand, it can reduce the weight of the holding part, preventing the sampler from being "top-heavy" and toppling over when cooperating with the self-test device.

[0133] The sampling and detection integrated device with the above structure has the following usage process:

[0134] See Figure 24 , the figure shows a schematic diagram of the device in its initial state. When in use, first, an independent sampling structure (preferably a swab) is used for sampling. Then, hold the holding part, remove the upper cap from the solution tube, and immediately insert the swab into the solution tube for dissolution (see Figure 25 ). Then, take out the swab from the solution tube, re-cover the upper cap onto the solution tube, then remove the limiting member located on the solution tube, press down the holding part, so that the holding part drives the solution tube to move downward, thereby making the bottom plate of the solution tube contact and be punctured by the tip part of the puncturing part. The liquid in the solution tube containing the dissolved sample flows into the surrounding space and contacts the first end of the test strip, finally realizing the running of the test strip, and the test result is displayed in the display area outside the solution tube.

[0135] Example Five

[0136] Different from Examples One to Four, see Figure 23 , a scraping structure 20 is provided inside the solution tube. The scraping structure 20 includes a collection area 202 and a scraping area 203 arranged in sequence from top to bottom. At least two scraping protrusions 204 are provided in the scraping area 203, and a scraping groove 205 is formed between two adjacent scraping protrusions 204. In some embodiments, the inner diameters of the exchange area and the collection area 202 gradually decrease from top to bottom, and the inner diameter of the scraping area 203 is the same along the height direction of the solution tube, so that the scraping structure 20 is in a funnel shape.

[0137] In some embodiments, the scraping structure 20 can be fixedly arranged inside the solution tube. In other embodiments, the scraping structure 20 can also be movably arranged inside the solution tube, similar to the structure of a piston.

[0138] It should be noted that the scraping structure is tightly connected to the solution tube. Even if the scraping structure is movably arranged inside the solution tube, when the sampling structure (sampler or swab) passes through the scraping structure, the scraping structure will not be driven to move.

[0139] For samples with a relatively large volume, such as feces (especially solid feces), the scraping structure 20 can be arranged in the upper half of the solution tube, that is, above the liquid level in the solution tube. When the sampler (specific structure see Example One) is inserted into the solution tube, when the collection part of the sampler passes through the scraping structure 20, the larger-particle samples (such as solid feces) fall off from the sampler under the action of the scraping structure 20 and are collected in the collection area 202, so as to prevent the sample from dissolving too much into the solution in the solution tube and prevent large-particle samples from entering the surrounding space and directly contacting the test strip, resulting in inaccurate measurement results.

[0140] That is to say, in the present application, by imposing a double restriction on the large-particle sample (first restricting it to the collection area, and even if the large-particle sample accidentally falls below the scraping structure, it is also restricted above the bottom plate with a relatively small gap after tearing), it effectively prevents the sample from entering the "open" enclosure space and directly contacting the test strip built therein, thus avoiding the problem of inaccurate measurement results. Herein, "open" means that there is no obstruction above the enclosure space and it is connected to the internal space of the test tube.

[0141] In some embodiments, at least one exchange hole 206 is provided at the top of the collection area 202 to form a solution exchange area 201 at the top of the collection area.

[0142] In some embodiments, a plurality of the exchange holes 206 are arranged circumferentially along the solution exchange area 201, and all of the plurality of exchange holes 206 are located at the top of the solution exchange area 201, that is, on the side where the solution exchange area 201 is connected to the solution tube.

[0143] For samples with a small quantity and / or volume, such as viruses, the scraping structure 20 can be arranged in the lower half of the solution tube so that it is immersed in the solution in the solution tube. When the swab is inserted into the solution tube, by scraping the swab on the scraping protrusion 204, the sample can be fully dissolved into the solution; and during the scraping process, the solution on the upper and lower sides of the scraping structure 20 can also achieve solution exchange through the exchange hole 206 under the agitation of the swab, as well as through the gap between the sampler and the scraping structure 20, so as to wash the sample on the scraping structure, making the sample in the solution more evenly distributed. And even if the sample or the swab completely blocks the scraping area 203, the exchange hole 206 can still meet the solution exchange requirement, thereby preventing the situation of difficult removal of the sampler caused by negative pressure.

[0144] In some embodiments, referring to Figure 27 , the scraping structure further includes a support portion 207, the inner diameter of the support portion 207 increases sequentially from top to bottom, the top of the support portion 207 is connected to the bottom of the scraping area, and the bottom of the support portion 207 abuts against the inner wall of the tube body. That is to say, both ends of the scraping structure are provided in a flared shape.

[0145] In some embodiments, at least one through hole 208 is provided on the support portion 207, and the through hole 208 communicates with the exchange hole 206.

[0146] In some embodiments, the outer diameter of the scraping structure is the same from top to bottom, and the outer wall of the scraping structure is tightly connected to the inner wall of the tube body. At least one exchange channel is provided inside the scraping structure, and the exchange hole and the through hole are communicated through the exchange channel.

[0147] The swabbing structure with the above structure can guide the swab and scrape the sample on the swab. First, the solution below the swabbing structure and the solution above the swabbing structure can be exchanged through the sequentially connected exchange holes, exchange channels and through holes, so that the samples in the solution are more evenly distributed. In addition, even if the swab is offset in the solution tube, it can move up and down without obstruction under the guiding action of the horn-shaped support part and the collection area, avoiding the situation where the swab is stuck and unable to move or be taken out in the swabbing structure. In addition, the outer wall of the swabbing structure is tightly connected to the inner wall of the tube. On the one hand, it can improve the connection strength between the movable swabbing structure and the tube. On the other hand, the larger swabbing structure can fill the internal space of the solution tube, thereby reducing the filling amount of the solution, saving production costs and making the sample concentration in the solution higher.

[0148] In summary, for samples of different volumes / quantities, the present application provides a solution that can make the samples "quantitatively" dissolved in the solution. Specifically, by adjusting the height of the swabbing structure, excessive samples are excluded from the solution, and a smaller sample volume can be dissolved in the solution as much as possible, and to ensure that it has a high sample concentration. That is, whether it is a sample with a large volume (such as feces) or a sample with a small quantity and / or volume (such as a virus), this device can stably collect and detect it, thus ensuring the reliability of the detection results.

[0149] It should be noted that in this article, the term "including", "comprising" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "including a..." does not exclude the existence of another identical element in the process, method, article or device including that element.

[0150] The embodiments of the present invention have been described above in conjunction with the accompanying drawings, but the present invention is not limited to the above specific embodiments. The above specific embodiments are merely illustrative and not restrictive. Under the inspiration of the present invention, those of ordinary skill in the art can also make many forms without departing from the spirit and scope protected by the present invention and the claims. These all fall within the protection scope of the present invention.

Claims

1. An integrated sampling and detection device, characterized in that Comprising: A sampler (1), a solution tube (2), a detection tube (3), and a base (4); both ends of the detection tube (3) are provided with openings, and the diameter of the detection tube (3) gradually increases from top to bottom. At least a part of the solution tube (2) is sleeved inside the detection tube (3), at least a part of the sampler (1) is sleeved inside the solution tube (2), and the base (4) cooperates with the opening at the bottom of the detection tube (3). The base (4) includes a bottom cover (41), as well as a retaining wall (42) and a puncturing part (43) provided on the bottom cover (41). The outer wall of the retaining wall fits with the inner wall of the detection tube (3). The puncturing part (43) is located inside the retaining space (46) formed by the retaining wall (42). The height of the retaining wall (42) is less than the height of the detection tube (3). The inner diameter of the top of the retaining wall (42) gradually decreases from top to bottom, so that a transition slope (44) is formed at the top of the retaining wall (42), and the solution above the retaining wall (42) can flow back into the retaining space (46) through the transition slope (44). A slot (45) is provided on one side of the retaining wall. The liquid level of the solution inside the retaining wall (42) is always below the slot (45). A detection space (31) for accommodating a test strip (6) is provided on the detection tube (3). An opening (32) communicating with the slot (45) is provided at the bottom of the detection space (31), so that the first end of the test strip (6) can extend out from the opening (32) and pass through the slot (45) into the retaining space (46).

2. The integrated sampling and detection device according to claim 1, characterized in that, The retaining wall includes a first baffle (421) and a second baffle (422) arranged successively from outside to inside. The height of the second baffle (422) is lower than the height of the first baffle (421). The first end of the first baffle (421) is connected to the first end of the second baffle (422) through a third baffle (423), and the transition slope (44) is formed on the first surface of the third baffle (423). The outer wall of the first baffle (421) fits with the inner wall of the detection tube (3). The first baffle (421), the second baffle (422), the third baffle (423), and the bottom cover (41) enclose to form a cavity (424).

3. The integrated sampling and detection device according to claim 2, wherein The retaining wall is recessed downward along its height direction near the opening (32) to form the slot (45). The parts of the retaining wall on both sides of the slot (45) are respectively recessed inward to form card slots (425) communicating with the retaining space (46). The card slots (425) are arranged along the height direction of the retaining wall. When the first end of the test strip is extended out from the opening (32) and the first end of the test strip is extended into the retaining space (46) along the card slot (425), both sides of the first end of the test strip are clamped into the card slot (425) for fixation.

4. The integrated sampling and detection device according to claim 1, characterized in that The solution tube (2) includes an integrally formed bottom plate (21) and a tube body (22). The bottom plate (21) is disposed at the bottom of the tube body (22). An opening for mating with the sampler (1) is provided at the top of the solution tube (2). A puncture groove (211) for mating with the tip of the puncture portion (43) is provided on the bottom plate (21), and the thickness of the puncture groove (211) is less than the thickness of the bottom plate (21).

5. The integrated sampling and detection device according to claim 1, wherein, A scraping structure (20) is provided inside the solution tube (2). The scraping structure (20) includes a solution exchange area (201), a collection area (202), and a scraping area (203) arranged in sequence from top to bottom. At least one exchange hole (206) is provided in the solution exchange area (201). At least two scraping protrusions (204) are provided in the scraping area (203), and a scraping groove (205) is formed between adjacent two scraping protrusions (204). The inner diameters of the exchange area and the collection area (202) gradually decrease from top to bottom, and the inner diameter of the scraping area (203) is the same along the height direction of the solution tube, so that the scraping structure (20) is in a funnel shape.

6. The integrated sampling and detection device according to any one of claims 1-5, characterized in that The sampler (1) includes: a holding portion (11), a coupling portion (12), a sampling rod (13), and a collection portion (14) connected in sequence from top to bottom. An installation space is formed by hollowing out the inside of the collection portion (14). At least one partition (144) is provided in the installation space along the width direction of the collection portion (14), and the at least one partition (144) divides the installation space into at least two accommodation cavities (145). A pointed structure (141) is provided at the first end of the collection portion (14). The pointed structure (141) includes a first surface, a second surface, a third surface, and a fourth surface connected in sequence. The first surface, the second surface, the third surface, and the fourth surface are arranged circumferentially along the pointed structure (141). Among them, the first surface and the third surface respectively form a guiding area (142) with a first inclination degree by inward depression.

7. The integrated sampling and detection device according to claim 6, wherein, A plurality of anti-slip protrusions (401) and / or a plurality of recessed portions are provided on the partition (144). The adjacent anti-slip protrusions (401) cooperate with the partition (144) to form a limiting structure, thereby dividing the accommodation cavity (145) into a plurality of accommodation areas (402).

8. The integrated sampling and detection device according to claim 6, characterized in that A plurality of partitions (144) are provided, and the plurality of partitions (144) are evenly arranged in the installation space, so that the heights of the plurality of accommodation cavities (145) are the same.

9. The integrated sampling and detection device according to claim 6, wherein A plurality of partitions (144) are provided, and the plurality of partitions (144) are unevenly arranged in the installation space to form a plurality of accommodation cavities (145) with different heights.

10. The integrated sampling and detection device according to claim 6, wherein, The second end of the installation space extends towards the second end of the collection portion (14) to form a transition area (143) with a second inclination degree.

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