Carrier cream of radiation shielding particles, radiation shielding cream as well as preparation method and application of radiation shielding cream

Abstract

The invention relates to the field of anti-radiation products, in particular to carrier cream of radiation shielding particles, radiation shielding cream and a preparation method and application of the radiation shielding cream. The carrier cream is prepared from ethylparaben, xanthan gum, cetostearyl alcohol, albolene, lauryl sodium sulfate, phenoxyethanol and deionized water, the mass ratio of the ethylparaben to the xanthan gum to the cetostearyl alcohol to the albolene to the lauryl sodium sulfate to the phenoxyethanol is any one of 1 to (0.4 to 0.6) to (7.5 to 8.5) to (7.5 to 8.5) to (0.9 to 1.1) to (0.9 to 1.1), and the mass fraction of the deionized water is any one of 80.5 percent to 93.5 percent. By adjusting the components and the mass ratio of the carrier cream, the carrier cream can bear high-content radiation shielding particles, so that the corrosion resistance of the radiation shielding cream is improved. And the viscosity of the carrier cream is convenient to adjust, so that the method is suitable for the addition amount of different radiation shielding particles.

Description

Technical Field

[0001] The present invention relates to the field of anti-radiation products, and particularly to a carrier cream for radiation shielding particles, a radiation shielding cream, and a preparation method and application thereof. Background Art

[0002] Ionizing radiation has been widely used in many fields such as medicine, industry, agriculture, energy, scientific research, and national defense. Especially in radiotherapy (RT), ionizing radiation has become one of the important means for treating various malignant tumors. However, while playing a therapeutic role, ionizing radiation may also cause radiation damage to non-target tissues. In particular, the potential harm of low-dose scatter radiation to healthy tissues cannot be ignored. In addition, with the development of the nuclear energy industry, the number of nuclear-related workers is increasing, and the demand for anti-radiation products is rising.

[0003] Currently, some researchers have developed a ray protection agent by uniformly mixing environmentally friendly and non-toxic radiation shielding particles with an ointment base matrix to protect the skin from direct and indirect radiation damage. However, when the content of the radiation shielding particles reaches 50%, the ointment will have problems such as difficulty in maintaining high-temperature stability and high viscosity, making it difficult to coat. Therefore, it is difficult to improve the anti-radiation effect of the cream by increasing the content of the radiation shielding particles or the coating thickness. Summary of the Invention

[0004] The purpose of the present invention is to provide a carrier cream for radiation shielding particles, a radiation shielding cream, and a preparation method and application thereof, which can carry a relatively high content of radiation shielding particles.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A carrier cream for radiation shielding particles, comprising ethylparaben, xanthan gum, cetearyl alcohol, white petrolatum, sodium lauryl sulfate, phenoxyethanol, and deionized water, and the mass ratio of the ethylparaben, the xanthan gum, the cetearyl alcohol, the white petrolatum, the sodium lauryl sulfate, and the phenoxyethanol is any value in 1:(0.4 - 0.6):(7.5 - 8.5):(7.5 - 8.5):(0.9 - 1.1):(0.9 - 1.1), and the mass fraction of the deionized water is any value in 80.5% - 93.5%.

[0007] In a second aspect, the present invention also provides a radiation shielding cream, comprising the above carrier cream and barium sulfate, and the mass of the barium sulfate is any value in 5% - 70% of the total mass.

[0008] In a third aspect, the present invention also provides a preparation method of the above radiation shielding cream, comprising:

[0009] Add the ethyl paraben to deionized water, stir and heat to the first temperature, then add the xanthan gum and continue stirring. After dissolution, an aqueous phase agent is obtained;

[0010] Mix the cetearyl alcohol, white petrolatum and sodium lauryl sulfate, heat to the first temperature and stir until homogeneous to obtain an oil phase agent;

[0011] Mix the aqueous phase agent and the oil phase agent and stir at the first temperature for emulsification and homogenization, then cool in a water bath to the second temperature, add the phenoxyethanol, stir evenly and cool to room temperature to obtain the carrier cream;

[0012] Transfer the carrier cream and the barium sulfate to a homogenizer for homogenization and mixing to obtain the radiation shielding cream.

[0013] Optionally, before mixing the carrier cream with the barium sulfate, add deionized water and stir for dilution.

[0014] Optionally, when diluting the carrier cream, the added deionized water is in a boiling state.

[0015] Optionally, the first temperature is any value between 80°C and 90°C, and the aqueous phase agent is obtained by stirring at a speed of any value between 180 rpm / min and 220 rpm / min, and the oil phase agent is obtained by stirring at a speed of any value between 500 rpm / min and 800 rpm / min.

[0016] Optionally, the stirring speed of the mixture of the aqueous phase agent and the oil phase agent is any value between 500 rpm / min and 800 rpm / min, the time is any value between 25 min and 30 min, and the second temperature is any value between 40°C and 60°C.

[0017] Optionally, the time for homogenization and mixing of the diluted carrier cream and the barium sulfate is any value between 10 min and 15 min.

[0018] Fourthly, the present invention also provides the application of the above radiation shielding cream, which is applied to the physical shielding of X-rays or strontium-90 rays on the skin surface.

[0019] The beneficial effects of the present invention are: by adjusting the components and mass ratio of the carrier cream, the carrier cream can carry a higher content of radiation shielding particles, thereby improving the antiseptic performance of the radiation shielding cream. The carrier cream of the present invention includes a large number of oily components with a relatively high melting point, thereby providing the carrier cream with a higher basic viscosity, ensuring the uniform dispersion and support of the radiation shielding particles. Sodium lauryl sulfate (K12) is a powerful anionic surfactant with good emulsification and dispersing capabilities. Cetearyl (C16-18) alcohol is both an emulsifier stabilizer and can form a liquid crystal structure, which helps to maintain the consistency and uniformity of the emulsion. The stable emulsification system formed by K12 and C16-18 alcohol can stabilize the oil phase, prevent precipitation due to the addition of water, and support radiation shielding particles. Xanthan gum is a hydrophilic polysaccharide as thickener, can be soluble in water and form a network structure, improve the rheological properties of the system, when additionally adding water, the concentration of xanthan gum decreases, but its hydration still exists, can maintain the stability of the emulsion, is not prone to phase separation, and xanthan gum can also improve the thixotropy of the emulsion, so that the system can still maintain a certain consistency after adding water, and water-oil separation will not occur. The water-soluble preservative system, i.e. phenoxyethanol and ethylparaben, is selected in the present invention, which can be evenly distributed in the aqueous phase, and after adding water, the balance of the preservative system will not be destroyed, thereby preventing the emulsion from being destabilized due to microbial contamination. Therefore, the carrier cream in the present invention can obtain different viscosities by regulating the content of water, and still has a higher supporting force when the viscosity is low, so that the radiation shielding particles are kept dispersed in the carrier cream, thereby carrying the larger radiation shielding particles in the water content when the moisture content is high. The carrier cream in the present invention is an oil-in-water (O / W) type as a whole, in which water serves as a continuous phase, and the oil phase components of white vaseline and cetearyl alcohol are stably dispersed in the water phase by an emulsifier. Therefore, by directly adding water, the additional water can be well dissolved and distributed in the water phase of the prepared carrier cream, and the viscosity can be adjusted without the occurrence of water-oil phase separation. This makes it easier for the carrier cream to adjust the viscosity in accordance with different amounts of radiation shielding particles added, reduces the difficulty of operation, and prevents the obtained radiation shielding cream from being too thin and difficult to apply thickly, or too dry and difficult to spread.

[0020] The above description is only an overview of the technical solution of the present invention. In order to more clearly understand the technical means of the present invention and implement it according to the contents of the specification, the following is a detailed description of the preferred embodiments of the present invention in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a flow chart of a method for preparing a radiation shielding cream as shown in Example 1 of the present invention;

[0022] Figure 2 This is an appearance diagram of radiation shielding creams with different barium sulfate contents shown in Example 1 of the present invention;

[0023] Figure 3 Schematic diagram of the number of clone formations in the cell cloning experiment shown in the first embodiment of the present invention;

[0024] Figure 4 Statistical chart of cell survival in the cytotoxicity test shown in the first embodiment of the present invention;

[0025] Figure 5 Schematic diagram of the experimental process and results in the animal experiment shown in the first embodiment of the present invention;

[0026] Figure 6 Result diagram of the cell cloning experiment of radiation shielding creams with different barium sulfate contents shown in the first embodiment of the present invention;

[0027] Figure 7 Result diagram of the cytotoxicity experiment of radiation shielding creams with different barium sulfate contents shown in the first embodiment of the present invention;

[0028] Figure 8 Statistical chart of the radiation shielding rate of radiation shielding creams with different barium sulfate contents in each embodiment of the present invention. Detailed implementation manners

[0029] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art without making creative efforts based on the embodiments of the present invention belong to the scope of protection of the present invention.

[0030] In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention. In addition, the terms "first", "second", "third" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0031] In the description of the present invention, it should be noted that unless otherwise clearly specified and limited, the terms "installed", "connected", "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication of two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.

[0032] In addition, the technical features involved in different embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.

[0033] In the prior art, lead rubber gloves are usually used as a protection means for interventional operations. However, the hardness and thickness of lead rubber gloves are relatively large, resulting in a significant increase in the operation difficulty. To address this technical problem, the inventor mixed environmentally friendly and non-toxic radiation shielding particles with a carrier cream to obtain a cream with radiation shielding function. By applying the cream to the hand and then wearing ordinary rubber gloves, the effect of shielding radiation can be achieved while ensuring the flexibility of the hand.

[0034] However, radiation shielding particles usually have relatively stable physical and chemical properties and are difficult to be evenly dispersed in the cream. Moreover, the addition of radiation shielding particles to the cream will also cause an increase in the viscosity of the cream. Therefore, the ability of the carrier cream to carry radiation shielding particles is usually poor. In the prior art, the particle content of radiation shielding cream is usually difficult to reach 50%, and its stability and ductility will decrease outside the practical range as the particle content increases, resulting in difficulty in further improving the shielding effect by increasing the particle content in the prior art.

[0035] The inventor accidentally discovered during the research that by adjusting the composition and ratio of the carrier cream, the ability of the carrier cream to carry radiation shielding particles can be improved. Based on the above discovery, the inventor developed a carrier cream with a strong ability to carry radiation shielding particles.

[0036] The present invention claims protection for a carrier cream for radiation shielding particles, which includes ethylparaben, xanthan gum, cetearyl alcohol, white petrolatum, sodium lauryl sulfate, phenoxyethanol, and deionized water. The mass ratio of ethylparaben, xanthan gum, cetearyl alcohol, white petrolatum, sodium lauryl sulfate, and phenoxyethanol is any value in the range of 1:(0.4 - 0.6):(7.5 - 8.5):(7.5 - 8.5):(0.9 - 1.1):(0.9 - 1.1), for example, it can be any value in (1:0.5:8:8:1:1), (1:0.4:7.8:8.3:1:1), (1:0.5:8:7.9:1.1:0.9), (1:0.6:8.2:8:1.1:1), and (1:0.5:8.3:7.7:0.9:1). The mass fraction of deionized water is any value in the range of 80.5% - 93.5%, for example, it can be any value in 80.5%, 81%, 85%, 89%, 93%, and 93.5%.

[0037] The carrier cream of the present invention contains a relatively large amount of oily components with a relatively high melting point, thereby providing a relatively high basic viscosity for the carrier cream, ensuring the uniform dispersion and support of the radiation shielding particles. Sodium dodecyl sulfate (K12) is a potent anionic surfactant with good emulsifying and dispersing capabilities. Cetearyl (C16-18) alcohol is both an emulsifying stabilizer and can form a liquid crystal structure, which helps to maintain the consistency and homogeneity of the emulsion. The stable emulsifying system formed by K12 and C16-18 alcohol can stabilize the oil phase and prevent precipitation due to the addition of water. Xanthan gum, as a thickening agent, is a hydrophilic polysaccharide that can dissolve in water and form a network structure, improving the rheological properties of the system. When additional water is added, the concentration of xanthan gum decreases, but its hydration still exists, which can maintain the stability of the emulsion, making it not prone to phase separation. Moreover, xanthan gum can also improve the thixotropy of the emulsion, enabling the system to still maintain a certain consistency after adding water without experiencing water-oil separation. In the present invention, a water-soluble preservative system, namely phenoxyethanol and ethylparaben, is selected, which can be evenly distributed in the water phase. After adding water, it will not disrupt the balance of the preservative system, thereby preventing the emulsion from becoming unstable due to microbial contamination. Therefore, by adjusting the water content, the carrier cream in the present invention can obtain different viscosities and still have a relatively high supporting force even when the viscosity is relatively low, enabling the radiation shielding particles to remain dispersed in the carrier cream, so that a relatively large amount of radiation shielding particles can be carried when the water content is relatively high. The carrier cream in the present invention is generally of the oil-in-water (O / W) type, where water is the continuous phase, and the oil-phase components of white petrolatum and cetearyl alcohol are stably dispersed in the water phase by the emulsifier. Therefore, by directly adding water, the additional water can be well dissolved and distributed in the water phase of the prepared carrier cream, achieving the adjustment of viscosity without occurring water-oil phase separation, facilitating the carrier cream to be able to adjust the viscosity in coordination with different addition amounts of radiation shielding particles, reducing the operation difficulty, and preventing the obtained radiation shielding cream from being too thin to be thickly applied or too dry to be spread.

[0038] In a second aspect, the present invention also provides a radiation shielding cream, comprising the above-mentioned carrier cream and barium sulfate, and the mass of barium sulfate is any value from 5% to 70% of the total mass, for example, it can be any value among 5%, 15%, 25%, 35%, 45%, 55%, 65% and 70%. The barium sulfate raw material has been approved to be legally used as a cosmetic raw material. Using barium sulfate as the radiation shielding particle helps to reduce the damage to the skin. By adjusting the content of barium sulfate, the radiation shielding cream is suitable for different application scenarios.

[0039] In a third aspect, please refer to Figure 1 , the present invention also provides a preparation method of the above-mentioned radiation shielding cream, comprising:

[0040] S1. Add ethyl paraben to deionized water, stir and heat to the first temperature, then add xanthan gum and continue stirring. After dissolution, an aqueous phase agent is obtained.

[0041] S2. Mix cetearyl alcohol, white petrolatum and sodium lauryl sulfate, heat to the first temperature and stir until homogeneous to obtain an oil phase agent.

[0042] S3. Mix the aqueous phase agent and the oil phase agent and stir at the first temperature for emulsification and homogenization, then cool in a water bath to the second temperature, add phenoxyethanol, stir evenly and cool to room temperature to obtain a carrier cream.

[0043] S4. Transfer the carrier cream and barium sulfate to a homogenizer for homogenization and mixing to obtain a radiation shielding cream.

[0044] In some embodiments, before mixing with barium sulfate, add deionized water to the carrier cream and stir to dilute it, which helps to adjust the viscosity of the carrier cream and the radiation shielding cream in accordance with the mass ratio of the carrier cream to barium sulfate.

[0045] In some embodiments, when diluting the carrier cream, the added deionized water is in a boiling state, which is convenient for accelerating the fusion of water and cream and reducing the risk of water-oil separation.

[0046] In some embodiments, the first temperature is any value in the range of 80 °C to 90 °C, and the aqueous phase agent is stirred at a speed of any value in the range of 180 rpm / min to 220 rpm / min, for example, it can be any value among 180 rpm / min, 190 rpm / min, 200 rpm / min, 210 rpm / min and 220 rpm / min. The oil phase agent is stirred at a speed of any value in the range of 500 rpm / min to 800 rpm / min, for example, it can be any value among 500 rpm / min, 600 rpm / min, 700 rpm / min and 800 rpm / min.

[0047] In some embodiments, the stirring speed of the mixture of the aqueous phase agent and the oil phase agent is any value in the range of 500 rpm / min to 800 rpm / min, for example, it can be any value among 500 rpm / min, 600 rpm / min, 700 rpm / min and 800 rpm / min, and the time is any value in the range of 25 min to 30 min, for example, it can be any value among 25 min, 26 min, 27 min, 28 min, 29 min and 30 min. The second temperature is any value in the range of 40 °C to 60 °C, for example, it can be any value among 40 °C, 44 °C, 48 °C, 52 °C, 56 °C and 60 °C.

[0048] In some embodiments, the time for the homogeneous mixing of the diluted carrier cream and barium sulfate is any value from 10 min to 15 min, for example, it can be any value among 10 min, 11 min, 12 min, 13 min, 14 min, and 15 min.

[0049] Fourthly, the present invention also provides the application of the above-mentioned radiation shielding cream, which is applied to the physical shielding of X-rays or strontium-90 rays on the skin surface.

[0050] For details, please refer to the following embodiments.

[0051] Example 1:

[0052] Please refer to Figure 1 , the preparation method of the radiation shielding cream shown in a preferred embodiment of the present application includes:

[0053] S1. Add ethylparaben to deionized water, stir and heat to the first temperature, then add xanthan gum and continue to stir until dissolved to obtain an aqueous phase agent.

[0054] S2. Mix cetearyl alcohol, white petrolatum, and sodium lauryl sulfate, heat to the first temperature and stir until homogeneous to obtain an oil phase agent.

[0055] S3. Mix the aqueous phase agent and the oil phase agent and stir at the first temperature for emulsification and homogenization, then cool to the second temperature in a water bath, add phenoxyethanol, stir evenly and cool to room temperature to obtain a carrier cream.

[0056] S4. Transfer the carrier cream and barium sulfate to a homogenizer for homogeneous mixing to obtain a radiation shielding cream.

[0057] In this embodiment, the mass of ethylparaben is 10 g, and the mass ratio of ethylparaben, xanthan gum, cetearyl alcohol, white petrolatum, sodium lauryl sulfate, phenoxyethanol, and deionized water is (1:0.5:8:8:1:1:80.5), and they are accurately weighed and reserved before preparation.

[0058] In step S1, the first temperature is 85 °C, stir in a water bath environment, and the stirring speed is 200 rpm / min.

[0059] In step S2, stir in a water bath environment, and the stirring speed is 700 rpm / min.

[0060] In step S3, mix the aqueous phase agent and the oil phase agent in a water bath environment at 85 °C, stir at a speed of 700 rpm / min for 30 min, and cool the homogeneous product to 50 °C with circulating water.

[0061] Step S4 includes:

[0062] S410. Add deionized water to the carrier cream obtained in step S3 and stir to mix, obtaining a diluted carrier cream.

[0063] S420. Add barium sulfate particles to the carrier cream obtained in step S420, and use a homogenizing mixer for homogenizing mixing and stirring.

[0064] In step S410, take 500 g of the carrier cream obtained in step S3, and add 1000 g of boiling deionized water, and stir and dilute until homogeneous.

[0065] In step S420, take 55 g of the carrier cream obtained in step S420 and 45 g of barium sulfate particles, and the homogenizing time is 15 min, obtaining a radiation shielding cream with a barium sulfate content of 45%.

[0066] In this embodiment, by adjusting the dosage of the carrier cream and barium sulfate particles in step S420, radiation shielding creams with barium sulfate contents of 45%, 55%, 65%, 70%, 75%, 80% and 85% are respectively prepared. For the appearance of the products, please refer to Figure 2 , it can be seen from the figure that when the content of barium sulfate particles reaches 75% and above, the radiation shielding cream shows the phenomenon of dryness and hardness, its ductility is limited, and it is not easy to apply; when the content of barium sulfate particles reaches 85%, it can no longer be mixed with the base matrix.

[0067] Conduct heat resistance and cold resistance tests on the radiation shielding cream with qualified properties. Among them, for the heat resistance test, refer to the method in QB / T18575.5.2, the National Light Industry Standard of the People's Republic of China - in vanishing cream. Take the radiation shielding cream and place it in an oven at 40°C ± 1°C for 24 h. After taking it out and standing until the temperature reaches room temperature, observe the change in the properties of the protective agent, and it is required that there is no oil-water separation phenomenon. For the heat resistance test, refer to the method in QB / T 18575.6.2. Take the radiation shielding cream and place it in a refrigerator at -5°C to -15°C for 24 h. After taking it out and standing until the temperature reaches room temperature, observe the change in the properties of the protective agent, and it is required that the oil seepage rate is not more than 3%. For the test results, please refer to Table 1 below.

[0068] Table 1:

[0069] Barium sulfate content in the radiation shielding cream Results of heat resistance test Results of cold resistance test 45％ Slightly dehydrated, no water-oil separation No abnormality 55％ Slightly dehydrated, no water-oil separation No abnormality 65％ Slightly dehydrated, no water-oil separation No abnormality 70％ Slightly dehydrated, no water-oil separation No abnormality

[0070] It can be seen from Table 1 that the radiation shielding creams with barium sulfate contents of 45% - 70% in this embodiment have no demulsification and delamination phenomena after high-temperature and low-temperature treatments, and have good property stability.

[0071] Determine the pH value of the radiation shielding cream by the dilution method in "General Test Methods for Cosmetics - Determination of pH Value" (GB / T 13531.1). Weigh 1 g of the radiation shielding cream sample, add 10 g of laboratory water that has been boiled and cooled, heat to 40 °C, and continuously stir until uniform. Then cool to 25 °C. After precipitation and filtration, use a pH meter to detect. The required range of the pH value is 4.0 - 8.5. In this example, the detected values of the radiation shielding cream with a barium sulfate concentration of 45% is 6.4, that with a barium sulfate concentration of 55% is 6.5, that with a barium sulfate concentration of 65% is 5.9, and that with a barium sulfate concentration of 70% is 6.8, all within the qualified range.

[0072] Detect the product safety of the radiation shielding cream through the human skin occlusive patch test. Select 12 volunteers aged between 18 and 60 years old who meet the test requirements as the test subjects, and use four radiation shielding creams with barium sulfate contents of 45% - 70% in this example as the test substances. Select qualified patch test devices with an area of about 50 mm 2 and a depth of about 1 mm. Place the test substance in the small chamber of the patch test device, and control the dosage between 0.020 g and 0.025 g. Apply the patch test device with the test substance on the flexor side of the forearm of the subject with a low-allergy tape, and gently press with the palm to make it evenly adhere to the skin for 24 h. Observe the skin reaction at 30 min, 6 h, 12 h, 24 h, and 48 h after removing the patch test device with the test substance, and observe and record the results based on Table 2 below, that is, the grading standard table of skin adverse reactions.

[0073] Table 2:

[0074]

[0075] In this example, no volunteer had skin adverse reactions such as erythema, papules, and blisters, and all subjects passed the patch test. This shows that the radiation shielding cream provided by the present invention has high safety and no irritation.

[0076] Detect the radiation shielding effect at the cellular level of the radiation shielding cream with a barium sulfate concentration of 45% obtained in this example through in vitro experiments.

[0077] Digest the mouse skin melanoma (B16) cells in the logarithmic growth phase to make a single-cell suspension, count and inoculate each well of the cell culture plate at the same cell density for cell cloning experiments. Coat the outer surface of the lid at the positions corresponding to two wells with the radiation shielding cream and the carrier cream obtained in step S3 respectively. During the culture process, irradiate X-rays into the uncovered well corresponding to one position from the outside to form a blank group sample, and irradiate the same X-rays into the well filled with the radiation shielding cream to form a 45% BaSO 4A group of samples, the same X-rays were irradiated into the wells filled with the carrier cream to form the basic matrix group samples. The wells without irradiation and coating treatment were cultured to obtain the 0 Gy group samples. After the culture was completed, the samples were stained with crystal violet staining solution, and the number of colony formations of each group of samples was detected. For the results, please refer to Figure 3 , it can be seen that the difference in the number of colony formations between the basic matrix group and the blank group is relatively small. For the 45% BaSO 4 group, the difference in the number of colony formations compared with the blank group is relatively large. It can be proved that the carrier cream itself hardly has the effect of reducing the inhibitory ability of X-rays on cell cloning, while the radiation shielding cream can effectively shield X-rays and reduce the inhibitory ability of X-rays on cell cloning.

[0078] B16 cells derived from melanin and immortalized human epidermal (HaCaT) cells were respectively inoculated into cell culture plates for cytotoxicity tests, and the cell densities of the same type of cells inoculated were the same. The wells corresponding to the two types of cells were respectively subjected to the same coating treatment and irradiation treatment as the above experiments to obtain the blank group, 45% BaSO 4 group, the basic matrix group and the 0 Gy group corresponding to the two types of cells. The cell viability was detected 3 days and 5 days after irradiation respectively, and the LDH expression was detected 3 days after irradiation. For the results, please refer to Figure 4 , it can be seen that the radiation shielding cream can effectively isolate the damage of X-rays to skin cells.

[0079] Female mice with a body weight of 18 g ± 2 g were used for animal experiments. After the mice were randomly grouped according to their body weights, they were respectively labeled as the blank group, the basic matrix group and 45% BaSO 4 group. Among them, the skin surface of the mice in the blank group was not smeared, and the mice in the basic matrix group and 45% BaSO 4 group were respectively smeared with the same thickness of the carrier cream and the radiation shielding cream on the skin surface. The mice were irradiated on the legs with an X-ray irradiator, and the mice were irradiated on the back with a mixed ray, that is, the β-ray and γ-ray generated by a strontium-90 radiation source. The irradiation dose was 10 Gy. 17 days after irradiation, the hair growth of the legs and backs of each group of mice was observed. Please refer to Figure 5 , it can be seen that the hair growth rate of the legs and backs of the mice smeared with the radiation shielding cream with 45% barium sulfate powder content is faster than that of the non-smearing group and the group smeared with the basic matrix, while the hair growth rate of the mice smeared with the basic matrix group is faster than that of the non-smearing group. At the animal level, it is proved that the radiation shielding cream with 45% barium sulfate powder content can effectively shield part of the X-rays and the mixed rays generated by the strontium-90 radiation source, and reduce the damage of irradiation to the hair follicles of mice.

[0080] Radiation shielding creams with barium sulfate concentrations of 45%, 55%, 65% and 70% were used for comparative experiments. Cell cloning experiments and cytotoxicity tests were respectively carried out by the same method as the above experiments, and the number of clone formations and cell viability were respectively counted. For the experimental results, please refer to Figure 6 and Figure 7 , it can be seen that the higher the barium sulfate concentration in the radiation shielding cream, the stronger the radiation shielding ability.

[0081] Example Two:

[0082] The difference between this example and Example One is only that in step S410 of this example, 500 g of the carrier cream obtained in step S3 is taken, and 500 g of boiling deionized water is added, and radiation shielding creams with barium sulfate concentrations of 25% and 35% are respectively prepared in step S420.

[0083] Example Three:

[0084] The difference between this example and Example One is only that in this example, step S410 is not included. The carrier cream obtained in step S3 is directly formulated with barium sulfate particles to obtain radiation shielding creams with barium sulfate concentrations of 5% and 15%.

[0085] Physical shielding experiments were carried out on the radiation shielding creams with barium sulfate concentrations of 5% - 55% in each example. Each radiation shielding cream was evenly applied to a culture dish with a diameter of 6 cm, and the application thicknesses were 0.5 mm, 1 mm and 2 mm respectively. Then each group of culture dishes was placed at a position 10 cm away from the strontium-90 radiation source, and a dosimeter was placed on the back of the culture dish to detect the radiation dose. For the experimental results, please refer to Figure 8 . It can be seen from the figure that when the application thickness is relatively thin, the physical shielding rate of the radiation shielding cream for the mixed rays of β-rays and γ-rays increases with the increase of the barium sulfate powder content, and the thicker the application thickness, the higher the physical shielding rate of the radiation shielding cream for the mixed rays. When the application thickness reaches 2 mm, the radiation shielding rate is close to 85%, which proves that the radiation shielding cream containing BaSO 4 powder can effectively shield the mixed rays generated by the strontium-90 radiation source.

[0086] The beneficial effects of the present invention are as follows: A carrier cream for carrying radiation shielding particles is provided. This carrier cream can carry a large number of radiation shielding particles, so as to obtain a radiation shielding cream with a high content of radiation shielding particles. This carrier cream can also obtain a diluted carrier cream with a lower viscosity and homogeneity by adding water to the finished product and simply stirring and mixing, which is convenient for users to adjust the viscosity according to the required concentration and usage scenario when preparing the radiation shielding cream, so as to obtain a radiation shielding cream suitable for the current environment. This carrier cream has a wide application range and high flexibility, and strong practicability.

[0087] The technical features of the above-described embodiments can be combined arbitrarily. For the sake of brevity of description, not all possible combinations of the various technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as falling within the scope described in this specification.

[0088] The above-described embodiments only express several implementation manners of the present invention, and the description thereof is relatively specific and detailed. However, it should not be construed as a limitation on the scope of the invention patent. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can still be made, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the invention patent should be subject to the appended claims.

Claims

1. A carrier cream of radiation shielding particles, characterized in that The invention comprises ethylparaben, xanthan gum, cetearyl alcohol, white vaseline, sodium lauryl sulfate, phenoxyethanol and deionized water, wherein the mass ratio of the ethylparaben, the xanthan gum, the cetearyl alcohol, the white vaseline, the sodium lauryl sulfate and the phenoxyethanol is any value in the range of 1: (0.4-0.6): (7.5-8.5): (7.5-8.5): (0.9-1.1): (0.9-1.1), and the mass fraction of the deionized water is any value in the range of 80.5%-93.5%.

2. A radiation shielding cream as claimed in claim 1, characterized in that: The invention comprises the carrier cream according to claim 1 and barium sulfate, wherein the mass of the barium sulfate is any value between 5% and 70% of the total mass.

3. A method for preparing the radiation shielding cream according to claim 2, characterized in that: include: Adding the ethylparaben to deionized water, stirring and heating to a first temperature, then adding the xanthan gum and continuing to stir, and obtaining an aqueous phase agent after dissolving; Mixing the cetearyl alcohol, the white vaseline and the sodium lauryl sulfate, heating to the first temperature and stirring until homogeneous, to obtain an oil phase agent; The water phase agent and the oil phase agent are mixed and stirred at the first temperature for emulsification and homogenization, and then cooled to a second temperature in a water bath, and the phenoxyethanol is added, stirred evenly and cooled to room temperature to obtain the carrier cream; The carrier cream and the barium sulfate are transferred together to a homogenizer for homogenizing and mixing to obtain the radiation shielding cream.

4. The preparation method according to claim 3, characterized in that: Before mixing the carrier cream with the barium sulfate, deionized water is added and stirred to dilute it.

5. The preparation method according to claim 4, characterized in that: When the carrier cream is diluted, the added deionized water is in a boiling state.

6. The preparation method according to claim 3, characterized in that: The first temperature is any value between 80°C and 90°C, and the aqueous phase agent is obtained by stirring at a speed between 180rpm / min and 220rpm / min, and the oil phase agent is obtained by stirring at a speed between 500rpm / min and 800rpm / min.

7. The preparation method according to claim 3, characterized in that: The stirring speed of the mixture of the water phase agent and the oil phase agent is any value in the range of 500 rpm / min to 800 rpm / min, the stirring time is any value in the range of 25 min to 30 min, and the second temperature is any value in the range of 40° C. to 60° C.

8. The preparation method according to claim 3, characterized in that: The time for homogenously mixing the diluted carrier cream and the barium sulfate is any value between 10 minutes and 15 minutes.

9. An application of the radiation shielding cream as claimed in claim 2, characterized in that: Physical shielding of X-rays or Strontium 90 rays applied to the surface of the skin.

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