Skin cosmetic composition

Abstract

Provided is a selective bactericide having an excellent bactericidal effect on propionibacterium acnes while suppressing a bactericidal effect on Staphylococcus epidermidis. A skin cosmetic composition characterized by containing (A) one or more substances selected from the group consisting of alkanediol having 8-12 carbon atoms and alkyl glyceryl ethers having 8-12 carbon atoms in the alkyl group, and (B) one or more substances selected from the group consisting of (B1)-(B6), and a cosmetic composition for the skin, the cosmetic composition being characterized by containing (A) one or more substances selected from the group consisting of alkanediol having 8-12 carbon atoms and alkyl glyceryl ethers having 8-12 carbon atoms in the alkyl group, and (B) one or more substances selected from the group consisting of (B1)-(B6).

Description

Technical Field

[0001] The present invention relates to a skin cosmetic composition. Background Art

[0002] In recent years, it has been known that reducing Propionibacterium acnes, which is the main cause of acne exacerbation, and maintaining a large amount of Staphylococcus epidermidis on the skin are effective as acne care (for example, see Non-Patent Document 1). For example, an acne external preparation composition containing isopropylmethylphenol has been proposed as an acne external preparation composition (for example, see Patent Document 1).

[0003] However, conventional external preparation compositions for acne, including Patent Document 1, contain isopropylmethylphenol, which has a broad antibacterial spectrum, as a general bactericidal component, and therefore there is a concern that it may sterilize not only Propionibacterium acnes but also Staphylococcus epidermidis. In addition, there is also a concern about the irritation of general bactericides such as isopropylmethylphenol to sensitive skin.

[0004] Therefore, it is desirable to provide a skin cosmetic composition having an excellent bactericidal effect on Propionibacterium acnes while suppressing the bactericidal effect on Staphylococcus epidermidis. [Prior art literature] [Patent Document]

[0005] [Patent Document 1] Japanese Patent Application Publication No. 2011-231082 [Non-patent literature]

[0006] [Non-patent document 1] Jean-Paul C, et al, (2019), Staphylococcus epidermidis A Potential New Player in the Physiopathology of Acne, Dermatology, 235 Summary of the invention [Problems to be Solved by the Invention]

[0007] The present invention aims to solve the above-mentioned problems and achieve the following objectives: Specifically, the present invention aims to provide a skin cosmetic composition having an excellent bactericidal effect against Propionibacterium acnes while suppressing the bactericidal effect against Staphylococcus epidermidis. [Methods for solving the problem]

[0008] The skin cosmetic composition of the present invention contains: (A) one or more selected from alkanediols having 8 to 12 carbon atoms and alkyl glyceryl ethers having 8 to 12 carbon atoms in the alkyl group; and (B) one or more nonionic surfactants selected from the following (B1) to (B6). (B1) Polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 65 or more and 100 or less (B2) a polyglycerol monofatty acid ester having 8 to 18 carbon atoms derived from a fatty acid and an average degree of polymerization of glycerol of 1 to 10 (B3) Polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 30 (B4) polyoxyethylene alkyl ether having an alkyl group with 12 to 18 carbon atoms and an average number of moles of ethylene oxide added of 5 to 30 (B5) a polyethylene glycol fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 30 (B6) Polyoxyethylene sorbitan monofatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average number of moles of ethylene oxide added of 4 to 30

[0009] The present invention is based on the findings of the present inventors, and as means for solving the above-mentioned problems, is as follows. <1> A skin cosmetic composition comprising: (A) at least one selected from alkanediols having 8 to 12 carbon atoms and alkyl glyceryl ethers having an alkyl group having 8 to 12 carbon atoms, and (B) One or more nonionic surfactants selected from the following (B1) to (B6). (B1) Polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 65 or more and 100 or less (B2) a polyglycerol monofatty acid ester having 8 to 18 carbon atoms derived from a fatty acid and an average degree of polymerization of glycerol of 1 to 10 (B3) Polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 30 (B4) polyoxyethylene alkyl ether having an alkyl group with 12 to 18 carbon atoms and an average number of moles of ethylene oxide added of 5 to 30 (B5) a polyethylene glycol fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 30 (B6) Polyoxyethylene sorbitan monofatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average number of moles of ethylene oxide added of 4 to 30 <2> according to <1> The skin cosmetic composition, wherein a mass ratio of the content of the component (A) to the content of the component (B) [(A) / (B)] is 0.37 or more and 1 or less. <3> according to <1> or <2> The skin cosmetic composition, wherein: The content of the component (A) is 0.05% by mass or more and 0.4% by mass or less relative to the total amount of the skin cosmetic composition, The content of the component (B) is 0.3% by mass or more and 4.0% by mass or less based on the total amount of the skin cosmetic composition. <4> according to <1> ~ <3> The skin cosmetic composition according to any one of the preceding claims, wherein the skin cosmetic composition contains (C) at least one selected from the group consisting of panthenol, pantothenyl ethyl ether, and pantothenic acid or a salt thereof. <5> according to <4> The skin cosmetic composition, wherein the content of the component (C) is 0.3% by mass or more and 1.0% by mass or less relative to the total amount of the skin cosmetic composition. <6> according to <1> ~ <5> The skin cosmetic composition according to any one of the preceding claims, wherein the skin cosmetic composition is a rinse-free type. <7> according to <1> ~ <6> The skin cosmetic composition according to any one of the preceding claims, wherein the skin cosmetic composition is a cream. [Effects of the Invention]

[0010] According to the present invention, it is possible to provide a skin cosmetic composition having an excellent bactericidal effect against Propionibacterium acnes while suppressing the bactericidal effect against Staphylococcus epidermidis. DETAILED DESCRIPTION

[0011] (Skin cosmetic composition) The skin cosmetic composition of the present invention contains: (A) one or more selected from alkanediols having 8 to 12 carbon atoms and alkyl glyceryl ethers having 8 to 12 carbon atoms in the alkyl group, and (B) one or more nonionic surfactants selected from the following (B1) to (B6), and may contain (C) one or more selected from panthenol, pantothenol ethyl ether and pantothenic acid or its salts and other ingredients as needed. (B1) Polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 65 or more and 100 or less (B2) a polyglycerol monofatty acid ester having 8 to 18 carbon atoms derived from a fatty acid and an average degree of polymerization of glycerol of 1 to 10 (B3) Polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 30 (B4) polyoxyethylene alkyl ether having an alkyl group with 12 to 18 carbon atoms and an average number of moles of ethylene oxide added of 5 to 30 (B5) a polyethylene glycol fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 30 (B6) Polyoxyethylene sorbitan monofatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average number of moles of ethylene oxide added of 4 to 30

[0012] In the present specification, “(A) one or more selected from alkanediols having 8 to 12 carbon atoms and alkyl glyceryl ethers having 8 to 12 carbon atoms in the alkyl group” may be referred to as “(A)” or “component (A)”. “(B) one or more nonionic surfactants selected from (B1) to (B6)” may be referred to as “(B)” or “(B) component”, “(B1) polyoxyethylene hydrogenated castor oil having an average number of moles of ethylene oxide added of 65 or more and 100 or less” may be referred to as “(B1)” or “(B1) component”, “(B2) polyglycerol monofatty acid ester having 8 or more and 18 or less carbon atoms derived from fatty acids and an average degree of polymerization of glycerol of 1 or more and 10 or less” may be referred to as “(B2)” or “(B2) component”, “(B3) polyoxyethylene sorbitan fatty acid ester having 12 or more and 18 or less carbon atoms derived from fatty acids and an average number of moles of ethylene oxide added of 5 or more and 30 or less” may be referred to as “(B3)” or “(B3) component”, “(B4) alkyl "(B4)" or "component (B4)" may be referred to as "polyoxyethylene alkyl ether having 12 to 18 carbon atoms and an average number of moles of ethylene oxide added of 5 to 30", "(B5) polyethylene glycol fatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average number of moles of ethylene oxide added of 5 to 30" may be referred to as "(B5)" or "component (B5)", "(B6) polyoxyethylene sorbitan monofatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average number of moles of ethylene oxide added of 4 to 30" may be referred to as "(B6)" or "component (B6)", and "(C) at least one selected from panthenol, pantothenol ethyl ether and pantothenic acid or its salts" may be referred to as "(C)" or "component (C)". In the present specification, the term "suppressing the bactericidal effect on Staphylococcus epidermidis" means that the ΔLog described below is less than 2, and the term "excellent bactericidal effect on Propionibacterium acnes" means that the ΔLog described below is 2 or more.

[0013] <(A) one or more selected from alkanediols having 8 to 12 carbon atoms and alkyl glyceryl ethers having an alkyl group having 8 to 12 carbon atoms> The component (A) imparts good bactericidal effect to the skin cosmetic composition.

[0014] -Alkanediol having 8 or more and 12 or less carbon atoms- The alkanediol having 8 to 12 carbon atoms is not particularly limited and may be appropriately selected depending on the intended purpose. However, from the viewpoint of good bactericidal activity, an alkanediol having 8 to 10 carbon atoms is preferred.

[0015] Specific examples of the alkanediol having 8 to 10 carbon atoms include 1,2-octanediol and 1,2-decanediol. These may be used alone or in combination of two or more.

[0016] The alkanediol having 8 to 12 carbon atoms may be an appropriately synthesized product or a commercially available product. Examples of commercially available products of the alkanediol having 8 to 12 carbon atoms include: Hydrolite CG (1,2-octanediol, manufactured by Daedal Industrial Co., Ltd.), 1,2-Decanediol (1,2-decanediol, manufactured by Tokyo Chemical Industry Co., Ltd.), 1,8-octanediol (C8, manufactured by Tokyo Chemical Industry Co., Ltd.), 1,2-nonanediol (C9, manufactured by Tokyo Chemical Industry Co., Ltd.), 1,9-nonanediol (C9, manufactured by Tokyo Chemical Industry Co., Ltd.), 1,10-decanediol (C10, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.), and the like.

[0017] -Alkyl glyceryl ether having an alkyl group with 8 to 12 carbon atoms- The alkyl glyceryl ether having an alkyl group with 8 to 12 carbon atoms is not particularly limited and can be appropriately selected depending on the intended purpose. However, from the viewpoint of good bactericidal activity, an alkyl glyceryl ether having an alkyl group with 8 to 10 carbon atoms is preferred.

[0018] Specific examples of the alkyl glyceryl ethers in which the alkyl group has 8 to 10 carbon atoms include ethylhexyl glycerin.

[0019] As the alkyl glyceryl ether having an alkyl group with 8 to 12 carbon atoms, an appropriately synthesized one may be used, or a commercially available one may be used. Examples of commercially available products of the alkyl glyceryl ethers in which the alkyl group has 8 to 12 carbon atoms include HIDAL-181 (ethylhexylglycerin, manufactured by Daedal Industrial Co., Ltd.) represented by the trade name.

[0020] The content of the component (A) is not particularly limited and may be appropriately selected depending on the purpose. However, from the perspective of a good selective bactericidal effect (high bactericidal activity against Propionibacterium acnes and an effect of suppressing bactericidal activity against Staphylococcus epidermidis), the content is preferably 0.01% by mass to 0.5% by mass, and more preferably 0.05% by mass to 0.4% by mass, relative to the total amount of the skin cosmetic composition. When the content of the component (A) is 0.01% by mass or more based on the total amount of the skin cosmetic composition, the bactericidal activity against Propionibacterium acnes is good. When the content of the component (A) is 0.5% by mass or less based on the total amount of the skin cosmetic composition, the effect of suppressing the bactericidal activity against Staphylococcus epidermidis is good.

[0021] <(B) One or more nonionic surfactants selected from (B1) to (B6)> The component (B) imparts a good selective bactericidal effect to the skin cosmetic composition.

[0022] The component (B) is one or more nonionic surfactants selected from the following components (B1) to (B6). (B1) Polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 65 or more and 100 or less (B2) a polyglycerol monofatty acid ester having 8 to 18 carbon atoms derived from a fatty acid and an average degree of polymerization of glycerol of 1 to 10 (B3) Polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 30 (B4) polyoxyethylene alkyl ether having an alkyl group with 12 to 18 carbon atoms and an average number of moles of ethylene oxide added of 5 to 30 (B5) a polyethylene glycol fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 30 (B6) Polyoxyethylene sorbitan monofatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average number of moles of ethylene oxide added of 4 to 30 Among them, from the viewpoint of good selective sterilization effect, component (B2), component (B3), component (B4), component (B5) and component (B6) are preferred, and component (B5) and component (B6) are more preferred.

[0023] -(B1) Polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 65 or more and 100 or less- The component (B1) is not particularly limited and may be appropriately selected depending on the intended purpose. However, polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 80 to 100 is preferred from the viewpoint of good selective bactericidal effect.

[0024] As the component (B1), a suitably synthesized substance may be used, or a commercially available product may be used. Examples of commercially available products of the component (B1) include: NIKKOL HCO-80 (polyoxyethylene hydrogenated castor oil, average number of moles of ethylene oxide added: 80) and NIKKOL HCO-100 (PEG-100 hydrogenated castor oil, average number of moles of ethylene oxide added: 100) represented by the trade names (each manufactured by Nikko Chemical Co., Ltd.).

[0025] -(B2) a polyglycerol monofatty acid ester having 8 to 18 carbon atoms derived from a fatty acid and an average degree of polymerization of glycerol of 1 to 10- The component (B2) is not particularly limited and can be appropriately selected according to the purpose. However, from the perspective of good selective sterilization effect, polyglycerol monofatty acid esters having a carbon number of 12 to 18 and an average degree of polymerization of glycerol of 1 to 10 are preferred.

[0026] As the component (B2), a product synthesized appropriately or a commercially available product may be used. Examples of commercially available products of the component (B2) include NIKKOL MGS-BV2 (glyceryl stearate, Nikko Chemical Co., Ltd.), NIKKOL Decaglyn 1-SVEX (polyglyceryl stearate-10, manufactured by Nikko Chemical Co., Ltd.), NIKKOL Decaglyn 1-LVEX (polyglyceryl laurate-10, manufactured by Nikko Chemical Co., Ltd.), SUNSOFT Q-81F-C (polyglyceryl caprylate-6, manufactured by Taiyo Chemical Co., Ltd.), SUNSOFT Q-10Y-C (polyglyceryl caprate-10 (C10), manufactured by Taiyo Chemical Co., Ltd.), NIKKOL Decaglyn 1-M (polyglyceryl myristate-10 (C14), manufactured by Nikko Chemical Co., Ltd.), NIKKOL Decaglyn 1-PVEX (polyglyceryl palmitate-10 (C16), manufactured by Nikko Chemical Co., Ltd.), NIKKOL Decaglyn 1-OV (polyglyceryl oleate-10 (C18), manufactured by Nikko Chemical Co., Ltd.), SUNSOFT Q-81F-C (polyglyceryl caprate-6 (C10), manufactured by Taiyo Chemical Co., Ltd.), NIKKOL Hexaglyn 1-M (polyglyceryl myristate-6 (C14), manufactured by Nikko Chemical Co., Ltd.), SY Glyster MO-5S (polyglyceryl oleate-6 (C18), manufactured by Sakamoto Pharmaceutical Co., Ltd.), NIKKOL Hexaglyn 1-SV (polyglyceryl stearate-6 (C18), manufactured by Nikko Chemical Co., Ltd.), SUNSOFT A-12E-C (polyglyceryl laurate-5 (C12), manufactured by Taiyo Chemical Co., Ltd.), SUNSOFT A-14E-C (polyglyceryl myristate-5 (C14), manufactured by Taiyo Chemical Co., Ltd.), SUNSOFT A-17E-C (polyglyceryl oleate-5 (C18), manufactured by Taiyo Chemical Co., Ltd.), SUNSOFT A-18E-C (polyglyceryl stearate-5 (C18), manufactured by Taiyo Chemical Co., Ltd.), SUNSOFT No.750-C (glyceryl laurate (C12), manufactured by Taiyo Chemical Co., Ltd.), NIKKOL MGM (glyceryl myristate (C14), manufactured by Nikko Chemical Co., Ltd.), SUNSOFT O-30S-C (glyceryl oleate (C18), manufactured by Taiyo Chemical Co., Ltd.), etc.

[0027] -(B3) a polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 30 The component (B3) is not particularly limited and can be appropriately selected according to the purpose. However, from the perspective of good selective sterilization effect, polyoxyethylene sorbitan fatty acid esters having a carbon number of 12 to 18 and an average added mole number of ethylene oxide of 5 to 20 are preferred.

[0028] As the component (B3), a product synthesized appropriately or a commercially available product may be used. Examples of commercially available products of the component (B3) include: NONION OT-221R (polyoxyethylene sorbitan monooleate (20 E.O.), manufactured by NOF Corporation), NIKKOL TS-30V (polysorbate 65, manufactured by Nikko Chemical Co., Ltd.), NIKKOL TS-106V (PEG-6 sorbitan stearate, manufactured by Nikko Chemical Co., Ltd.), etc., represented by the trade name.

[0029] -(B4) a polyoxyethylene alkyl ether having an alkyl group with 12 to 18 carbon atoms and an average number of moles of ethylene oxide added of 5 to 30 The component (B4) is not particularly limited and can be appropriately selected according to the purpose. However, from the perspective of improving the selective sterilization effect, polyoxyethylene alkyl ethers having an alkyl group with carbon atoms of 12 to 18 and an average number of moles of ethylene oxide added of 5 to 20 are preferred, and polyoxyethylene alkyl ethers having an alkyl group with carbon atoms of 12 to 18 and an average number of moles of ethylene oxide added of 8 to 20 are more preferred.

[0030] As the component (B4), a product synthesized appropriately or a commercially available product may be used. Examples of commercially available products of the component (B4) include: MONOPOL LAE7 (C12C14 coconut oil EO-5, manufactured by DONGNAM Chemical Co., Ltd.), EMALEX 608 (Steareth-8), EMALEX 610 (Steareth-10), EMALEX 611 (Steareth-11), EMALEX 615 (Steareth-15), EMALEX 620 (Steareth-20), EMALEX 630 (Steareth-30) (all represented by trade names, manufactured by Nippon Emulsion Co., Ltd.), and the like.

[0031] -(B5) a polyethylene glycol fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 30 The component (B5) is not particularly limited and can be appropriately selected according to the purpose. However, from the perspective of improving the selective sterilization effect, polyethylene glycol fatty acid esters having a carbon number of 12 to 18 and an average number of ethylene oxide added of 5 to 11 are preferred, and polyethylene glycol fatty acid esters having a carbon number of 12 to 18 and an average number of ethylene oxide added of 5 to 11 are more preferred.

[0032] Specific examples of the component (B5) include polyethylene glycol monolaurate (average number of moles of EO added: 10), polyethylene glycol monooleate (average number of moles of EO added: 10), polyethylene glycol monooleate (average number of moles of EO added: 6), and the like. Among them, polyethylene glycol monolaurate (average number of added moles of EO: 10) is preferred because it has a good bactericidal activity against Propionibacterium acnes and a good selective bactericidal effect.

[0033] As the component (B5), a product synthesized appropriately or a commercially available product may be used. As commercially available products of the component (B5), for example, there can be mentioned: MYL-10 (polyethylene glycol monolaurate (10EO), manufactured by Nikko Chemical Co., Ltd.), MYO-10V (polyethylene glycol monooleate (10EO), manufactured by Nikko Chemical Co., Ltd.), MYO-6V (polyethylene glycol monooleate (6EO), manufactured by Nikko Chemical Co., Ltd.), etc. represented by the trade names.

[0034] -(B6) a polyoxyethylene sorbitan monofatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 4 to 30 The component (B6) is not particularly limited and can be appropriately selected according to the purpose. However, from the perspective of improving the selective bactericidal effect, it is preferably a polyoxyethylene sorbitan monofatty acid ester in which the number of carbon atoms from the fatty acid is from 12 to 18 and the average number of added moles of ethylene oxide is from 4 to 8.

[0035] As the component (B6), a product synthesized appropriately or a commercially available product may be used. Examples of commercially available products of the component (B6) include GL-1 (polyoxyethylene sorbitan monolaurate (6EO), manufactured by Nikko Chemical Co., Ltd.) represented by the trade name.

[0036] The content of the component (B) is not particularly limited and may be appropriately selected depending on the intended purpose. However, from the viewpoint of achieving a good selective bactericidal effect, it is preferably 0.1% by mass to 5.0% by mass, more preferably 0.3% by mass to 4.0% by mass, based on the total amount of the skin cosmetic composition. When the content of the component (B) is 0.1% by mass or more based on the total amount of the skin cosmetic composition, the bactericidal activity against Propionibacterium acnes is good. When the content of the component (B) is 5.0% by mass or less based on the total amount of the skin cosmetic composition, the effect of suppressing the bactericidal activity against Staphylococcus epidermidis is good.

[0037] <Mass ratio [(A) / (B)]> In the skin cosmetic composition of the present invention, from the viewpoint of the inhibitory effect on the bactericidal activity of Staphylococcus epidermidis and the good bactericidal activity against Propionibacterium acnes, the mass ratio [(A) / (B)] of the content of the component (A) to the content of the component (B) is preferably 0.04 to 1.7, and more preferably 0.37 to 1.0. When the mass ratio [(A) / (B)] is 0.04 or more, the bactericidal activity against Propionibacterium acnes is good. When the mass ratio [(A) / (B)] is 1.7 or less, the effect of suppressing the bactericidal activity against Staphylococcus epidermidis is good.

[0038] <(C) at least one selected from panthenol, panthenol ethyl ether and pantothenic acid or its salt> The component (C) imparts good bactericidal activity against Propionibacterium acnes to the skin cosmetic composition.

[0039] The component (C) is not particularly limited and may be appropriately selected depending on the intended purpose. However, from the viewpoint of obtaining a good bactericidal activity against Propionibacterium acnes, panthenol and pantothenol ethyl ether are preferred.

[0040] As the component (C), a product synthesized appropriately or a commercially available product may be used. Examples of commercially available products of the component (C) include D-Pantothenyl Alcohol (panthenol, manufactured by BASF Japan Ltd.), Pantothenic Acid (Technical Grade, Contains Lactone) (pantothenic acid, manufactured by Toronto Research Chemicals Inc.), Sodium D-Pantothenate (sodium pantothenate, manufactured by Tokyo Chemical Industry Co., Ltd.), and Calcium D-Pantothenate (calcium pantothenate, manufactured by Tokyo Chemical Industry Co., Ltd.).

[0041] The content of the component (C) is not particularly limited and may be appropriately selected depending on the intended purpose. However, from the perspective of having a good bactericidal effect on Propionibacterium acnes, the content is preferably 0.1% by mass to 1.0% by mass, and more preferably 0.3% by mass to 1.0% by mass, relative to the total amount of the skin cosmetic composition. When the content of the component (C) is 0.1% by mass or more based on the total amount of the skin cosmetic composition, the bactericidal activity against Propionibacterium acnes is good. When the content of the component (C) is 1.0% by mass or less based on the total amount of the skin cosmetic composition, the bactericidal activity against Propionibacterium acnes is good.

[0042] <Other ingredients> The skin cosmetic composition of the present invention may contain other components in addition to the above-mentioned components (A) to (C) as needed within a range not impairing the effects of the present invention. Examples of the other ingredients include anti-inflammatory agents, vitamin agents other than the component (C), surfactants other than the component (B), preservatives, water-soluble polymers, oils, silicones, alcohols such as lower or higher alcohols, pH adjusters, antioxidants, metal chelating agents, pigments, fragrances, cooling agents, moisturizers, amino acids, and the like. These may be used alone or in combination of two or more. As the other components, those which are appropriately synthesized may be used, or commercially available products may be used. The content of the other components in the skin cosmetic composition is not particularly limited and may be appropriately selected depending on the intended purpose.

[0043] - Anti-inflammatory Agents - The anti-inflammatory agent is not particularly limited and can be appropriately selected according to the purpose. For example, tranexamic acid, glycyrrhetinic acid, glycyrrhizic acid or pharmaceutically acceptable derivatives thereof or salts thereof (e.g., dipotassium glycyrrhizinate), licorice extract, steroid compounds (hydrocortisone, prednisolone, methylprednisolone, clobetasone, betamethasone, dexamethasone, cortisone, flumethasone, beclomethasone, fluticasone or pharmaceutically acceptable derivatives thereof or salts thereof), indomethacin, ibuprofen, ibuprofen picolide, and the like. piconol), bufexamac, ufenamate, piroxicam, ketoprofen, salicylic acid or its pharmaceutically acceptable derivatives or their salts, dimethyl isopropylazulene, angelica extract, purple root extract, etc.

[0044] - Vitamins other than ingredient (C) - The vitamin agents other than the component (C) are not particularly limited and can be appropriately selected according to the purpose. For example, the vitamin agents include vitamins A, vitamins B6, vitamin C, vitamin E, vitamin B1, vitamin B2, vitamin B3, vitamin B12, biotin, folic acid and pharmaceutically acceptable derivatives or salts thereof, vitamin D, other vitamins, etc.

[0045] Examples of the vitamin A include retinol and pharmaceutically acceptable derivatives thereof or salts thereof (eg, retinyl palmitate, retinyl acetate, retinol, retinal, retinoic acid, retinoids, etc.).

[0046] Examples of the vitamin B6 include pyridoxine and pharmaceutically acceptable derivatives thereof or salts thereof (eg, pyridoxine, pyridoxal, etc.).

[0047] Examples of the vitamin C include ascorbic acid and pharmaceutically acceptable derivatives thereof or salts thereof (e.g., ascorbic acid, sodium ascorbate, magnesium ascorbyl phosphate, trisodium ascorbyl palmitate phosphate, isoascorbic acid, ascorbic acid 2-glucoside, ascorbyl palmitate, etc.).

[0048] As the vitamin E, for example, tocopherol and its pharmaceutically acceptable derivatives or salts thereof (for example, d-α-tocopherol, dl-α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, mixed tocopherols, α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, vitamin E acetate (tocopherol acetate), vitamin E nicotinate, vitamin E succinate, vitamin E linolenate, natural vitamin E, etc.) and the like can be mentioned.

[0049] Examples of the vitamin B1 include thiamine and pharmaceutically acceptable derivatives thereof or salts thereof (eg, thiamine hydrochloride, thiamine nitrate, etc.).

[0050] Examples of the vitamin B2 include riboflavin and pharmaceutically acceptable derivatives thereof or salts thereof (eg, riboflavin phosphate, riboflavin sodium phosphate, riboflavin butyrate, flavin adenine dinucleotide sodium, etc.).

[0051] Examples of the vitamin B3 include nicotinic acid and pharmaceutically acceptable derivatives thereof or salts thereof (nicotinic acid amide, nicotinic acid benzyl ester, etc.).

[0052] Examples of the vitamin B12 include cobalamin and its derivatives and pharmaceutically acceptable derivatives thereof or salts thereof (e.g., cyanocobalamin, mecobalamin, hydroxocobalamin hydrochloride, etc.).

[0053] Examples of the vitamin D include calciferol and pharmaceutically acceptable derivatives thereof or salts thereof (eg, ergocalciferol, cholecalciferol, etc.).

[0054] Examples of the other vitamins include hesperidin, carnitine, ferulic acid, γ-oryzanol, orotic acid, rutin, eriocitrin, inositol, and pharmaceutically acceptable derivatives thereof or salts thereof.

[0055] -Surfactants other than component (B)- The surfactant other than the component (B) is not particularly limited and can be appropriately selected according to the purpose, and examples thereof include ionic surfactants, etc. Examples of the ionic surfactant include N-coconut oil fatty acid acyl-DL-alanine triethanolamine liquid, etc.

[0056] -preservative- The preservative may be included in the skin cosmetic composition, but is preferably not included. From the perspective of selective bactericidal effect, the specific content of the preservative is preferably 0.09 mass % or less, more preferably 0.01 mass % or less, and further preferably 0.001 mass % or less relative to the total amount of the skin cosmetic composition.

[0057] - Cooling agent - The cooling agent is not particularly limited and may be appropriately selected according to the purpose. Examples thereof include l-menthol, camphor, borneol or the like, anise oil, eucalyptus oil, mentha oil, peppermint oil, and spearmint oil.

[0058] - Moisturizer - The moisturizing agent is not particularly limited and can be appropriately selected according to the purpose. For example, polyols (glycerol, 1,3-butylene glycol, 1,2-pentanediol, etc.), sugar alcohols (sorbitol, etc.), hyaluronic acid or its derivatives, heparin analogs, polymer compounds (collagen [protein], chitosan, etc.), amino acids, natural moisturizing factors (sodium lactate, urea, etc.), ceramides, vegetable oils (olive oil, etc.), plant extracts (soybean extract, chamomile extract, aloe extract, etc.), etc. can be mentioned.

[0059] -Amino Acids- The amino acids are not particularly limited and can be appropriately selected according to the purpose. Examples thereof include glutamic acid, aspartic acid, glycine, alanine, serine, aminoethanesulfonic acid (taurine), and pharmaceutically acceptable salts thereof (e.g., ephedrine hydrochloride, methylephedrine hydrochloride, etc.).

[0060] As the above-mentioned other components, in addition to the above-mentioned substances, the following hydrocarbons can be used: vaseline, paraffin, liquid paraffin, squalane, ceresin, gelled hydrocarbons and microcrystalline wax; higher fatty acids such as stearic acid, isostearic acid, myristic acid, palmitic acid, oleic acid and behenic acid; higher fatty alcohols such as cetyl alcohol, stearyl alcohol and behenyl alcohol; fatty acid ester oils such as isopropyl myristate, octyldodecanol myristate, isopropyl palmitate and diisopropyl adipate; triglycerol fatty acid esters such as triisooctanoin and tri(caprylic / capric)glyceryl; polyols such as propylene glycol and polyethylene glycol; organic solvents such as acetone, methyl ethyl ketone and ethyl acetate; diisopropanolamine, triethanolamine, lauric acid diethanolamide (lauric acid diethanolamide) and the like. pH adjusters such as disodium edetate, edetate, edetate, pyrophosphate, hexametaphosphate, citric acid, tartaric acid, gluconic acid, etc.; preservatives such as parabens (methyl paraben, ethyl paraben, butyl paraben), boric acid and borax; cellulose derivatives such as hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose (carmellose), cross-linked carboxymethyl cellulose, ethyl cellulose and methyl cellulose; processed starches such as some alpha starch, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, cross-linked polyvinylpyrrolidone, polyethylene glycol, xanthan gum, caramel Thickeners such as gum, sodium alginate, gum arabic, guar gum, tamarind gum, karaya gum, carob gum, tragacanth gum, locust bean gum, pullulan, gelatin, carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, sodium polyacrylate, hydroxyethyl acrylate / acryloyldimethyl taurate crosspolymer, quince seed (quince), casein, dextrin, sodium pectinate, dimethylacrylamide / acryloyldimethyl taurate crosspolymer, dialkyldimethylammonium cellulose sulfate, bentonite, hectorite, magnesium aluminum silicate, synthetic hectorite (Laponite), anhydrous silicic acid, etc.; blending flavors such as citrus fragrance, floral fragrance, rose fragrance, etc.; essential oils (natural fragrances) such as peppermint oil, eucalyptus oil, bergamot oil, rose oil, rosemary oil, lavender oil and lemon oil, etc.; pearlescent agents such as ethylene glycol distearate, etc.

[0061] The pH of the skin cosmetic composition at 25° C. is not particularly limited and can be appropriately selected according to the purpose, but is preferably 3.0 or more, more preferably 3.5 or more, from the viewpoint of good bactericidal activity against Propionibacterium acnes. In addition, it is preferably 10 or less, more preferably 9 or less, from the viewpoint of good skin irritation resistance. The pH can be measured, for example, based on the Japanese Pharmacopoeia, 18th edition / General Test Methods (measurement temperature: 25° C.).

[0062] The viscosity of the skin cosmetic composition at 30° C. is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 10 Pa·s or more and 200 Pa·s or less.

[0063] The dosage form / properties of the skin cosmetic composition of the present invention are not particularly limited as long as it can be applied transdermally, and may be any of liquid, solid, semisolid (gel, ointment, paste, foam), etc. In addition, the embodiment may be any of the forms of a skin external medicine, a skin external quasi-drug, a skin cleanser (facial lotion, etc.), and a skin cosmetic (lotion, moisturizer, whitening agent, etc.).

[0064] The formulation form of the skin cosmetic composition of the present invention is not particularly limited and can be appropriately selected according to the purpose. For example, the formulation form can include: ointment; cream; lotion; gel; emulsion; liquid; patch; spray spray in mist or foam; aerosol spray in mist, powder, foam or paste; mask; body shampoo; shampoo; conditioner, etc. Among them, ointment, cream, lotion, gel, aerosol, spray, emulsion, and mask are preferred, and cream, lotion, and emulsion are more preferred. The emulsified state of creams or emulsions is not particularly limited, and can be any of water-in-oil type (W / O), oil-in-water type (O / W) and multiple emulsions (W / O / W, O / W / O).

[0065] -Method for producing skin cosmetic composition- The method for producing the skin cosmetic composition of the present invention is not particularly limited and can be appropriately selected depending on the purpose. The composition can be obtained by mixing the component (A), the component (B), the component (C) as required, the other components, and purified water (the remainder is blended so that the entire amount of the skin cosmetic composition becomes 100% by mass).

[0066] The skin cosmetic composition can be prepared using an apparatus. The apparatus is not particularly limited and can be appropriately selected according to the purpose, and examples thereof include a stirring apparatus having a shearing force and a stirring blade capable of mixing the entire composition. The stirring blade is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include a propeller, a turbine, and a disperser.

[0067] -use- The application site and application method of the skin cosmetic composition are not particularly limited and may be appropriately selected depending on the purpose. For example, the composition may be applied to the whole body, face, hands, back, etc. in a conventional application method. The use of the skin cosmetic composition is not particularly limited and can be appropriately selected depending on the purpose. For example, the composition can be used as a moisturizer such as a lotion or cream for acne care. The skin cosmetic composition can be a type that does not need to be rinsed off after application. [Example]

[0068] The present invention is described in detail below with reference to Examples and Comparative Examples, but the present invention is not limited to these Examples. The content of each component described in the Examples and Comparative Examples is expressed in "mass %", the total amount is 100 mass %, and all are values ​​converted to pure components.

[0069] (Examples 1 to 23 and Comparative Examples 1 to 6) The respective components were mixed according to the compositions and contents shown in Examples 1 to 23 and Comparative Examples 1 to 6 to prepare respective skin cosmetic compositions.

[0070] The "bactericidal activity" of each skin cosmetic composition was evaluated and judged as follows. The results are shown in Tables 1 to 5 below.

[0071] <Evaluation of Bactericidal Power> The bactericidal activity was evaluated using the following two types of fungi. Staphylococcus epidermidis: Staphylococcus epidermidis, NBRC 12993 Propionibacterium acnes: Cutibacterium acnes, NBRC 107605 First, each bacterium was cultured in a flat agar medium. For the culture medium of Staphylococcus epidermidis, a flat SCDLP agar medium (398-00265, manufactured by Shiota MSCO., LTD) was used, and for the culture medium of Propionibacterium acnes, a flat GAM agar medium (05420, manufactured by Nissui Pharmaceutical Co., Ltd.) was used. Then, each bacterial solution was prepared to 1.0×10 7 Pieces / mL. 0.1 g of the prepared bacterial solution was added to 10 g of each skin cosmetic composition or 10 g of 3° hard water as a control, and the bacterial mixture was prepared and left to stand at 30°C for 6 hours. Next, 0.3 g of the bacterial mixture was suspended in 2.7 mL of SCDLP medium (398-00265, manufactured by Shioya MS Co., Ltd.), and then diluted in stages to an appropriate bacterial concentration. For the mixed solution containing Staphylococcus epidermidis, 1 mL of the bacterial solution diluted in each stage was evenly applied on the SCDLP plate agar medium and cultured aerobically at 37°C for 1 to 2 days. For the mixed solution containing Propionibacterium acnes, 1 mL of the bacterial solution diluted in each stage was evenly applied on the GAM agar plate medium and cultured anaerobically at 37°C for 2 to 3 days. After cultivation, the number of colonies was counted as the number of viable bacteria. The ΔLog value was calculated according to the following formula, and the bactericidal power of each sample was determined based on the following judgment criteria. It should be noted that "△" or above is qualified. It should be noted that the number of samples was 2, and the average value was used for determination. (Formula) ΔLog = Log (number of viable bacteria when using the control) - Log (number of viable bacteria when using each skin cosmetic composition) -Judgment criteria (bactericidal activity against Propionibacterium acnes)- +++: ΔLog is 4.0 or more ++: ΔLog is 3 or more and less than 4.0 +: ΔLog is greater than 2 and less than 3 -: ΔLog is less than 2 -Judgment criteria (bactericidal activity against Staphylococcus epidermidis)- ++: ΔLog is 2 or more +: ΔLog is greater than 1 and less than 2 -: ΔLog is less than 1 -Judgment Criteria (Selective Sterilization)- ◎◎: The evaluation of the bactericidal activity against Propionibacterium acnes was “+++”, and the evaluation of the bactericidal activity against Staphylococcus epidermidis was “-” ◎: The evaluation of the bactericidal activity against Propionibacterium acnes was “++”, and the evaluation of the bactericidal activity against Staphylococcus epidermidis was “-” ○: The evaluation of the bactericidal activity against Propionibacterium acnes was “+”, and the evaluation of the bactericidal activity against Staphylococcus epidermidis was “-” △: The evaluation of bactericidal activity against Propionibacterium acnes is “++” or “+”, and the evaluation of bactericidal activity against Staphylococcus epidermidis is “+” ×: The bactericidal activity against Propionibacterium acnes was evaluated as “-”, or the bactericidal activity against Staphylococcus epidermidis was evaluated as “++”

[0072] [Table 1]

[0073] [Table 2]

[0074] [Table 3]

[0075] [Table 4]

[0076] [Table 5]

[0077] The details of the components used in Examples 1 to 23 and Comparative Examples 1 to 6 are shown in Table 6 below.

[0078] [Table 6]

[0079] (Prescription Examples 1 to 4) By the same method as in Example 1, a skin cosmetic composition (cream) having the composition and content shown in Table 7 below was prepared.

[0080] [Table 7]

[0081] The details of the components used in Formulation Examples 1 to 4 are shown in Tables 8 and 9 below.

[0082] [Table 8]

[0083] [Table 9] [Industrial Applicability]

[0084] Since the skin cosmetic composition has an excellent bactericidal effect on Propionibacterium acnes while suppressing the bactericidal effect on Staphylococcus epidermidis, it can be suitably used in moisturizers such as acne care lotions and creams, for example.

Claims

1. A skin cosmetic composition, characterized in that contain: A: one or more selected from alkanediols having 8 to 12 carbon atoms and alkyl glyceryl ethers having 8 to 12 carbon atoms in the alkyl group, and B: one or more nonionic surfactants selected from the following B1 to B6: B1: polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 65 or more and 100 or less; B2: a polyglycerol monofatty acid ester having 8 to 18 carbon atoms derived from a fatty acid and an average degree of polymerization of glycerol of 1 to 10; B3: a polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 30; B4: polyoxyethylene alkyl ether having an alkyl group with 12 to 18 carbon atoms and an average number of moles of ethylene oxide added of 5 to 30; B5: a polyethylene glycol fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 30; B6: a polyoxyethylene sorbitan monofatty acid ester in which the number of carbon atoms derived from the fatty acid is 12 to 18 and the average number of moles of ethylene oxide added is 4 to 30.

2. The skin cosmetic composition according to claim 1, wherein The mass ratio [A / B] of the content of the component A to the content of the component B is 0.37 or more and 1 or less.

3. The skin cosmetic composition according to claim 1 or 2, wherein: The content of the component A is 0.05% by mass or more and 0.4% by mass or less relative to the total amount of the skin cosmetic composition, The content of the component B is 0.3% by mass or more and 4.0% by mass or less based on the total amount of the skin cosmetic composition.

4. The skin cosmetic composition according to claim 1 or 2, wherein: contain C: at least one selected from the group consisting of panthenol, panthenol ethyl ether and pantothenic acid or its salts.

5. The skin cosmetic composition according to claim 4, wherein The content of the component C is 0.3% by mass or more and 1.0% by mass or less based on the total amount of the skin cosmetic composition.

6. The skin cosmetic composition according to claim 1 or 2, wherein: The skin cosmetic composition is a leave-on type.

7. The skin cosmetic composition according to claim 1 or 2, wherein: The skin cosmetic composition is a cream.

8. The skin cosmetic composition according to claim 1 or 2, wherein: B1: polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 80 or more and 100 or less; B3: a polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 20; B4: polyoxyethylene alkyl ether having an alkyl group with 12 to 18 carbon atoms and an average number of moles of ethylene oxide added of 5 to 20; B5: a polyethylene glycol fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average number of moles of ethylene oxide added of 5 to 11; B6: a polyoxyethylene sorbitan monofatty acid ester in which the number of carbon atoms derived from the fatty acid is 12 to 18 and the average number of moles of ethylene oxide added is 4 to 8.

9. The skin cosmetic composition according to claim 3, wherein: The content of the component B is 0.3% by mass or more and 3.0% by mass or less based on the total amount of the skin cosmetic composition.

Images