Device for uniformly mixing and stirring viral protein and adjuvant

Abstract

The invention discloses a virus protein and adjuvant mixing and stirring device which comprises a base, a telescopic rod is arranged on the side face of the base, a connecting block is rotatably connected to the upper portion of the telescopic rod, a stirring mechanism used for stirring the interior of a stirring barrel is arranged below the connecting block, and the stirring mechanism comprises a stirring cover plate below the connecting block; an on-cover motor is fixedly connected to the upper portion of the stirring cover plate, a ratchet disc is fixedly connected to the output end of the on-cover motor, an under-disc motor is arranged below the ratchet disc, and a connecting disc is fixedly connected to the output end of the under-disc motor. The device has highly-automatic cleaning and stirring processes, and the production efficiency and safety are greatly improved. After stirring is completed, an operator only needs to control the motor push column to contract through the control box, and the device can automatically start a cleaning program. The inner wall of the stirring barrel is efficiently cleaned, so that an operator is prevented from being in direct contact with residual virus protein and adjuvant with biological activity and potential danger, and the health risk is effectively reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of mixing and stirring equipment, and particularly to a virus protein and adjuvant mixing and stirring device. Background Art

[0002] In the production process of vaccines, as a key antigen to stimulate the body's immune response, virus proteins need to be fully mixed with adjuvants to enhance the immune effect. Both virus proteins and adjuvants have special physical and chemical properties. Virus proteins are usually extremely sensitive to factors such as temperature and shear force. Excessive temperature or excessive shear force may cause changes in their spatial structure, thereby losing their immunogenicity. Adjuvants need to be accurately proportioned and evenly dispersed with virus proteins to play their role in enhancing the immune response.

[0003] However, virus proteins and adjuvants may have certain biological activities and potential hazards. During the manual cleaning process, operators may come into contact with residual virus proteins and adjuvants. If the protective measures are improper, it is easy to cause health problems. Moreover, during the cleaning process, due to the uncertainty of manual operation, safety accidents such as collisions and damages to the stirring tank may occur. The speed of manual cleaning may be such that cleaning is not timely, resulting in the stirring tank being unable to be put into the next round of production on time, interrupting the continuity of production. This patent aims to provide a kitchenware storage rack to alleviate the technical problem of inconvenient use of kitchenware storage racks in the prior art. Summary of the Invention

[0004] The purpose of the present invention is to solve the disadvantages existing in the prior art, that is, virus proteins and adjuvants may have certain biological activities and potential hazards. During the manual cleaning process, operators may come into contact with residual virus proteins and adjuvants. If the protective measures are improper, it is easy to cause health problems. Moreover, during the cleaning process, due to the uncertainty of manual operation, safety accidents such as collisions and damages to the stirring tank may occur. The speed of manual cleaning may be such that cleaning is not timely, resulting in the stirring tank being unable to be put into the next round of production on time, interrupting the continuity of production, and to propose a virus protein and adjuvant mixing and stirring device.

[0005] In order to achieve the above purpose, the present invention adopts the following technical solutions: A mixing and stirring device for a virus protein and an adjuvant, comprising a base. A telescopic rod is arranged on the side of the base. A connecting block is rotatably connected above the telescopic rod. A stirring mechanism for the inside of a stirring barrel is arranged below the connecting block. The stirring mechanism includes a stirring cover plate below the connecting block. A cover motor is fixedly connected above the stirring cover plate. The output end of the cover motor is fixedly connected with a ratchet disc. A disc-bottom motor is arranged below the ratchet disc. The output end of the disc-bottom motor is fixedly connected with a connecting disc. First convex columns and second convex columns are arranged on the surface of the connecting disc. The first convex columns and the second convex columns are used to push a corner block and a T-shaped push block. A rotating bearing is arranged on the side of the ratchet disc. The rotating bearing is drivingly connected with a stirring frame. Square grooves are formed on the surface of the stirring frame. The T-shaped push block is fixed inside the square grooves. The corner block is slidably connected with the stirring frame. A ratchet pawl is arranged on the side of the ratchet disc. The ratchet pawl is rotatably connected with an adapter block. The adapter block is fixed on the inner wall of a rotating ring. A push spring is fixedly connected to the side of the ratchet pawl. One side of the push spring away from the ratchet pawl is fixedly connected with the rotating ring. One end of the rotating ring away from the stirring cover plate is fixedly connected with a scraping plate.

[0006] The above technical solution further includes: The corner block is rotatably connected with the ratchet disc. The corner block is slidably connected with an extending block. The extending block is fixed inside the square groove. The square groove is slidably connected with the ratchet disc. The rotating ring is rotatably connected with the corner block. By setting the passive movement of the corner block and the extending block, the left and right movement of the stirring frame is promoted, so as to realize the uniform stirring of the inside of the stirring barrel.

[0007] A control box is fixedly connected to the side of the base. An arc heater is fixedly connected to the side of the control box.

[0008] A plurality of rotating bearings are arranged on the surface of the ratchet disc. The rotating bearings are respectively arranged on both sides of the stirring frame. By arranging multiple groups of bearings on the surface of the ratchet disc, the stability of the stirring frame during the sliding process is ensured.

[0009] A plurality of cleaning strips for cleaning the inner wall of the stirring barrel are arranged on the surface of the connecting disc. By arranging the plurality of cleaning strips on the surface of the connecting disc, the scraping effect of the solution inside the stirring barrel can be well achieved, so as to realize the cleaning treatment.

[0010] A motor push post is fixedly connected to the side of the stirring cover plate away from the cover motor. The motor push post is used to fix the adapter block.

[0011] A conduction layer is arranged inside the stirring barrel. A coating that does not react with the solution is arranged on the inner wall of the stirring barrel. By arranging the conduction layer, the temperature requirement of the solution during heating can be well ensured.

[0012] A liquid outlet valve is provided on the side of the mixing barrel, and the mixing barrel is fixedly connected to a liquid outlet pipe. The outlet of the liquid outlet pipe penetrates through the arc-shaped heater and extends to the outside.

[0013] A receiving barrel is provided on the side of the telescopic rod, and the receiving barrel is used for collecting the solution inside the mixing barrel.

[0014] Buttons are provided on the surface of the control box, and a display screen is also provided on the surface of the control box. By setting the buttons on the surface of the control box, the functions such as heating and stirring of the device can be used well, and the display screen set on the surface of the control box can play a good visual effect, making the situation inside the device clear at a glance.

[0015] The present invention has the following beneficial effects: 0. In the present invention, the device has a highly automated cleaning and stirring process, which greatly improves production efficiency and safety. After the stirring is completed, the operator only needs to control the motor push rod to contract through the control box, and the device can automatically start the cleaning program. Components such as the connecting block, rotating ring, and connecting plate cooperate to efficiently clean the inner wall of the mixing barrel, eliminating the need for manual operation and avoiding direct contact between the operator and the remaining virus proteins and adjuvants with biological activity and potential danger, effectively reducing the health risk. At the same time, the automated cleaning is fast and efficient, and can complete the cleaning work in a short time, ensuring that the mixing barrel can be put into the next round of production on time and guaranteeing the continuity of production.

[0016] 1. In the present invention, during the stirring process, the automated precise control also reduces the uncertainty of manual operation, avoids safety accidents such as collisions and damages of the mixing barrel caused by improper manual operation, makes the entire production process safer and more reliable, greatly improves production efficiency, and reduces production costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is a schematic structural diagram of a virus protein and adjuvant mixing and stirring device proposed by the present invention; Figure 2 is a schematic side view structure of the present invention; Figure 3 is a schematic side view structure of the stirring mechanism of the present invention; Figure 4 is Figure 3 an enlarged schematic view of part A in Figure 5 is a schematic bottom view structure of the stirring mechanism of the present invention; Figure 6 is a schematic top view structure of the present invention.

[0018] In the figure: 1, base; 2, mixing barrel; 3, arc heater; 4, control box; 5, receiving barrel; 6, telescopic rod; 7, connecting block; 8, mixing cover plate; 9, cover motor; 10, liquid outlet valve; 11, liquid outlet pipe; 12, rotating ring; 13, scraping plate; 14, ratchet disc; 15, connecting disc; 16, first convex column; 17, second convex column; 18, corner block; 19, T-shaped push block; 20, rotating bearing; 21, mixing frame; 22, square groove; 23, ratchet pawl; 24, push spring; 25, connecting block; 26, motor push column; 27, motor under the disc; 28, protruding block. Detailed implementation mode

[0019] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0020] Please refer to Figures 1-6 As shown, the present invention is a virus protein and adjuvant mixing and stirring device, including a base 1. A telescopic rod 6 is arranged on the side of the base 1. A connecting block 7 is rotatably connected above the telescopic rod 6. A stirring mechanism for the inside of the mixing barrel 2 is arranged below the connecting block 7. The stirring mechanism includes a mixing cover plate 8 below the connecting block 7. A cover motor 9 is fixedly connected above the mixing cover plate 8. The output end of the cover motor 9 is fixedly connected with a ratchet disc 14. A motor 27 under the disc is arranged below the ratchet disc 14. The output end of the motor 27 under the disc is fixedly connected with a connecting disc 15. The surface of the connecting disc 15 is provided with a first convex column 16 and a second convex column 17 for pushing the corner block 18 and the T-shaped push block 19. A rotating bearing 20 is arranged on the side of the ratchet disc 14. The rotating bearing 20 is drivingly connected with a mixing frame 21. A square groove 22 is opened on the surface of the mixing frame 21. The T-shaped push block 19 is fixed inside the square groove 22. The corner block 18 is slidably connected with the mixing frame 21. A ratchet pawl 23 is arranged on the side of the ratchet disc 14. The ratchet pawl 23 is rotatably connected with a connecting block 25. The connecting block 25 is fixed on the inner wall of the rotating ring 12. A push spring 24 is fixedly connected to the side of the ratchet pawl 23. One side of the push spring 24 away from the ratchet pawl 23 is fixedly connected with the rotating ring 12. One end of the rotating ring 12 away from the mixing cover plate 8 is fixedly connected with a scraping plate 13.

[0021] In one embodiment, for the above-mentioned corner block 18 and protruding block 28, the corner block 18 is rotatably connected with the ratchet disc 14, the corner block 18 is slidably connected with the protruding block 28, the protruding block 28 is fixed inside the square groove 22, the square groove 22 is slidably connected with the ratchet disc 14, and the rotating ring 12 is rotatably connected with the corner block 18.

[0022] In this embodiment, by setting the corner block 18 and the protruding block 28 to move passively, the left and right movement of the stirring frame 21 is promoted, so as to achieve uniform stirring inside the stirring barrel 2.

[0023] In one embodiment, for the above-mentioned control box 4, the control box 4 is fixedly connected to the side of the base 1, and the arc heater 3 is fixedly connected to the side of the control box 4.

[0024] In one embodiment, for the above-mentioned ratchet disc 14, a plurality of rotating bearings 20 are arranged on the surface of the ratchet disc 14, and the rotating bearings 20 are respectively arranged on both sides of the stirring frame 21.

[0025] In this embodiment, by setting multiple groups of bearings on the surface of the ratchet disc 14, the stability of the stirring frame 21 during the sliding process is ensured.

[0026] In one embodiment, for the above-mentioned connecting disc 15, a plurality of cleaning strips for cleaning the inner wall of the stirring barrel 2 are arranged on the surface of the connecting disc 15.

[0027] In this embodiment, by setting multiple groups of cleaning strips on the surface of the connecting disc 15, the scraping effect of the solution inside the stirring barrel 2 can be achieved well, so as to realize the cleaning treatment.

[0028] In one embodiment, for the above-mentioned motor push column 26, the motor push column 26 is fixedly connected to the side of the stirring cover plate 8 away from the motor 9 on the cover, and the motor push column 26 is used for fixing the connecting block 25.

[0029] In this embodiment, by setting the electric push column 26, the service life of the connecting block 25 can be ensured, and the number of maintenance times can be reduced.

[0030] In one embodiment, for the above-mentioned stirring barrel 2, a conduction layer is arranged inside the stirring barrel 2, and a plating layer that does not react with the solution is arranged on the inner wall of the stirring barrel 2.

[0031] In this embodiment, by setting the conduction layer, the temperature requirement of the solution during heating can be well ensured, so as to ensure the significance of stirring.

[0032] In one embodiment, a liquid outlet valve 10 is arranged on the side of the stirring barrel 2, the stirring barrel 2 is fixedly connected to the liquid outlet pipe 11, and the outlet of the liquid outlet pipe 11 penetrates through the arc heater 3 and extends to the outside.

[0033] In one embodiment, a receiving barrel 5 is arranged on the side of the telescopic rod 6, and the receiving barrel 5 is used for collecting the solution inside the stirring barrel 2.

[0034] In one embodiment, buttons are arranged on the surface of the control box 4, and a display screen is also arranged on the surface of the control box 4.

[0035] The present invention is a device for mixing and stirring viral proteins and adjuvants. Its working principle is to check whether the rotation of each group of motors in the device is normal before use, and to perform a series of processes such as high-temperature disinfection. After the inspection is correct, the subsequent stirring process is prepared. In a sterile operating environment, the operator wears sterile work clothes, gloves, masks and other protective equipment to ensure the cleanliness of himself and the operating environment. Then, the control box 4 is used to control the telescopic rod 6 to extend and retract, and the stirring cover plate 8 is moved upward to prepare for adding materials.

[0036] To facilitate the subsequent dispersion and mixing of materials, an appropriate amount of sterile solvent or buffer solution can be added to the stirring barrel 2, and the motor 9 on the cover can be turned on. The ratchet disk 14 is used to rotate the stirring frame 21 to stir the inside of the stirring barrel 2 at a low speed, so that the solution forms a stable flow field. The accurately weighed or measured viral protein is slowly added to the stirring barrel 2. During the addition process, the viral protein should be prevented from adhering to the inner wall of the stirring barrel 2 as much as possible. At the same time, the stirring state is maintained to allow the viral protein to be initially dispersed in the solution. After the viral protein is fully dispersed, the adjuvant is slowly added to the container in the order and speed required by the process. Attention should also be paid to the method of addition to avoid excessive local concentration or violent chemical reactions. The stirring speed can be appropriately adjusted during the addition process to allow the adjuvant to fully contact and mix with the viral protein solution.

[0037] During the stirring process, the control box 4 can be used to control the motor 27 under the plate to rotate. The rotation of the motor 27 under the plate further drives the connection plate 15 to rotate. The first boss 16 and the second boss 17 on the surface of the connection plate 15 will reciprocate to push the corner block 18. After one end of the corner block 18 is pushed, it will drive the stirring frame 21 to slide to the right along the surface of the rotating bearing 20. As the connection plate 15 continues to rotate, the second boss 17 pushes the T-shaped push block 19 to move to the left. Since the T-shaped push block 19 is fixed in the square groove 22 inside the stirring frame 21, the stirring frame 21 will also move to the left. As the connection plate 15 continues to rotate, the second boss 17 rotates to one end of the corner block 18. The second boss 17 will push the corner block 18 to rotate on the surface of the ratchet plate 14 to continue to move the stirring frame 21 to the right. The connection plate 15 continues to rotate, and the first boss 16 will push the second boss 17 to further drive the stirring frame 21 to move to the left. Therefore, during the rotation of the connecting plate 15, the stirring frame 21 will reciprocate left and right on the surface of the rotating bearing 20 to uniformly stir the mixed liquid inside the mixing barrel 2. Since the rotation of the cover motor 9 will drive the ratchet plate 14 to rotate, the stirring frame 21 will stir the stirring liquid inside the mixing barrel 2 in a cylindrical manner. In addition, during the stirring process, the control box 4 is used to control the motor push column 26 to extend and retract, further fixing the connecting block 25 to prevent the scraper plate 13 from rotating.

[0038] After the stirring is completed, there will be residual mixed liquid on the inner wall of the stirring barrel 2. The control box 4 is used to control the motor push rod 26 to contract. At this time, the connecting block 25 is no longer fixed and rotates in the direction opposite to the rotation of the ratchet disc 14. At this time, the rotation of the ratchet disc 14 will abut against the side wall of the pawl 23. When the ratchet disc 14 continues to rotate, it will push the pawl 23, and the pawl 23 will be stuck in the groove of the ratchet. Then the rotation of the ratchet disc 14 pushes the pawl 23, and the pawl 23 at this time pushes the connecting block 25, so that the rotating ring 12 rotates at the bottom of the stirring cover plate 8. At the same time, the rotation of the rotating ring 12 drives the connecting disc 15 to clean the inner wall of the stirring barrel 2. After multiple rotations, the cleaning effect is ensured.

[0039] If it is necessary to replace the stirring device, the telescopic rod 6 is used to lift it, and then the connecting block 7 is rotated to lower it, and then the details are repaired or cleaned. At this time, if the stirring work continues, the stirring mechanism can be replaced. The stirring mechanism includes the connecting part below the stirring cover plate 8. At this time, when a new stirring mechanism is replaced, the stirring work can continue, so as to provide cleaning time for the old stirring device.

[0040] Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A device for mixing viral protein and adjuvant, characterized in that: The invention comprises a base (1), a telescopic rod (6) is arranged on the side of the base (1), a connecting block (7) is rotatably connected to the top of the telescopic rod (6), a stirring mechanism for stirring the inside of the stirring barrel (2) is arranged below the connecting block (7), the stirring mechanism comprises a stirring cover plate (8) below the connecting block (7), a cover motor (9) is fixedly connected to the top of the stirring cover plate (8), the output end of the cover motor (9) is fixedly connected to a ratchet disc (14), a lower disc motor (27) is arranged below the ratchet disc (14), the output end of the lower disc motor (27) is fixedly connected to a connecting disc (15), a first boss (16) and a second boss (17) are arranged on the surface of the connecting disc (15), the first boss (16) and the second boss (17) are used to stir the corner block (18) and the T-shaped push block (18). 9), a rotating bearing (20) is arranged on the side of the ratchet disc (14), the rotating bearing (20) is drivingly connected to the stirring frame (21), a square groove (22) is provided on the surface of the stirring frame (21), the T-shaped push block (19) is fixed inside the square groove (22), the corner block (18) is slidably connected to the stirring frame (21), a pawl (23) is arranged on the side of the ratchet disc (14), the pawl (23) is rotatably connected to a connecting block (25), the connecting block (25) is fixed on the inner wall of the rotating ring (12), a push spring (24) is fixedly connected to the side of the pawl (23), the side of the push spring (24) away from the pawl (23) is fixedly connected to the rotating ring (12), and the end of the rotating ring (12) away from the stirring cover plate (8) is fixedly connected to the scraper plate (13).

2. A viral protein and adjuvant mixing and stirring device according to claim 1, characterized in that: The corner block (18) is rotatably connected to the ratchet disc (14), the corner block (18) is slidably connected to the extension block (28), the extension block (28) is fixed inside the square groove (22), the square groove (22) is slidably connected to the ratchet disc (14), and the rotating ring (12) is rotatably connected to the corner block (18).

3. A viral protein and adjuvant mixing and stirring device according to claim 1, characterized in that: A control box (4) is fixedly connected to the side of the base (1), and an arc heater (3) is fixedly connected to the side of the control box (4).

4. A viral protein and adjuvant mixing and stirring device according to claim 1, characterized in that: A plurality of rotary bearings (20) are arranged on the surface of the ratchet disc (14), and the rotary bearings (20) are respectively arranged on both sides of the stirring frame (21).

5. A viral protein and adjuvant mixing and stirring device according to claim 1, characterized in that: The surface of the connecting plate (15) is provided with a plurality of groups of cleaning strips for cleaning the inner wall of the mixing barrel (2).

6. A viral protein and adjuvant mixing and stirring device according to claim 1, characterized in that: A motor push column (26) is fixedly connected to the side of the stirring cover plate (8) away from the cover motor (9), and the motor push column (26) is used to fix the connection block (25).

7. A viral protein and adjuvant mixing and stirring device according to claim 1, characterized in that: A conductive layer is provided inside the stirring barrel (2), and an inner wall of the stirring barrel (2) is provided with a coating layer that is not reactive with the solution.

8. A viral protein and adjuvant mixing and stirring device according to claim 1, characterized in that: A liquid outlet valve (10) is provided on the side of the stirring barrel (2), and the stirring barrel (2) is fixedly connected to a liquid outlet pipe (11), and an outlet of the liquid outlet pipe (11) passes through the arc heater (3) and extends to the outside.

9. A viral protein and adjuvant mixing and stirring device according to claim 1, characterized in that: A receiving bucket (5) is provided on the side of the telescopic rod (6), and the receiving bucket (5) is used to collect the solution inside the stirring bucket (2).

10. A viral protein and adjuvant mixing and stirring device according to claim 3, characterized in that: The surface of the control box (4) is provided with buttons, and the surface of the control box (4) is also provided with a display screen.

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