Traditional Chinese medicine preparation for treating rhinitis and nasosinusitis

Abstract

The invention belongs to the technical field of traditional Chinese medicine formulas, and particularly discloses a traditional Chinese medicine preparation for treating rhinitis and nasosinusitis. The traditional Chinese medicine preparation comprises the following traditional Chinese medicine raw material components in parts by mass: 7-12 parts of ligusticum; 6-11 parts of pogostemon cablin; 6-11 parts of white mulberry root-bark; 7-12 parts of magnolia flower; 2-4 parts of asarum; 6-12 parts of fried cocklebur fruit; 6-11 parts of poria cocos; and 6-11 parts of dahurian angelica root. The traditional Chinese medicine preparation for treating rhinitis and nasosinusitis is refined in materials and small in side effect, and has a good curative effect on rhinitis, nasosinusitis and the like.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine formulations, and relates to a traditional Chinese medicine for preventing and treating otolaryngological diseases, specifically to a traditional Chinese medicine preparation for treating rhinitis and sinusitis. Background Art

[0002] Rhinitis and sinusitis are inflammations in the nasal cavity, both having symptoms such as nasal congestion, runny nose, sneezing, headache, and facial tenderness, which greatly endanger the physical health of patients, may affect the normal work and life of patients, and may also cause other more serious complications. It can be seen that the harm of rhinitis and sinusitis cannot be underestimated. Especially for sinusitis, patients will also have symptoms such as purulent nasal discharge and olfactory hypoesthesia.

[0003] Rhinitis patients are more likely to be in an anxious and depressive state than the general population. This disease can lead to sleep structure disorders and daytime fatigue in patients, bringing inconvenience to their social life. Currently, common drug treatments are used, such as antibiotics and nasal corticosteroids, to control infections and reduce inflammation. At the same time, nasal irrigation can also be used in combination for treatment. However, these drug treatments have a long treatment cycle, lack of persistent efficacy, are prone to recurrence, and have adverse reactions such as local nosebleeds, headaches, and pharyngitis. Therefore, it is particularly important to develop a drug for treating rhinitis or sinusitis that is safe, has no side effects, and has a rapid and significant therapeutic effect. Summary of the Invention

[0004] The purpose of the present invention is to provide a traditional Chinese medicine preparation for treating rhinitis and sinusitis. This traditional Chinese medicine preparation uses refined raw materials, has few side effects, and has good curative effects on rhinitis, sinusitis, etc.

[0005] In order to achieve the above purpose, the present invention adopts the following technical solutions:

[0006] A traditional Chinese medicine preparation for treating rhinitis and sinusitis contains the following raw material components of traditional Chinese medicine in parts by mass:

[0007]

[0008] In the present invention, the following raw material components of traditional Chinese medicine in parts by mass are preferably used:

[0009]

[0010] The traditional Chinese medicine preparation of the present invention is mainly based on "expelling wind and cold, dredging orifices and resolving dampness", and has good curative effects on symptoms such as nasal congestion, headache, and nasal sinusitis (sinusitis) caused by "wind-cold-damp pathogen". The specific drug effects are as follows:

[0011] Ligusticum sinense: It has the medicinal effects of dispelling wind and cold, relieving pain, and is especially good at treating headache on the top of the head. Modern research shows that Ligusticum sinense mainly contains phthalide components (ligustilide, 1,3-dilinolein, 3-butylphthalide, cnidilide, etc.) and organic acid components (ferulic acid, etc.), and also contains terpenoids, allylbenzenes, coumarins, etc. It has the effects of antipyretic, analgesic, anti-inflammatory, improving hypoxia tolerance, antidiarrheal and antithrombotic.

[0012] Pogostemon cablin: Mainly produced in Guangdong, it can aromatize dampness, harmonize the middle-jiao to stop vomiting, and promote appetite; it also has the medicinal effects of removing dampness from the body, relieving nausea, and relieving summer heat.

[0013] Mulberry Bark: Mulberry Bark is a traditional Chinese medicine that can relieve cough and asthma, mainly used to relieve discomfort in the lungs and asthma problems, and can also help eliminate edema. It is often used to improve cough caused by lung heat, body edema, and unsmooth urination. Modern research found that it contains flavonoids, coumarins, as well as components such as polysaccharides and tannins, and these components jointly play the roles of relieving cough and asthma, promoting diuresis and detumescence.

[0014] Magnolia Flower Bud: A traditional Chinese medicine with the effect of dispersing wind-cold, it can help disperse cold on the body surface, dredge the nasal cavity and relieve headache, and is often used to improve symptoms such as nasal congestion, incessant runny nose, and frontal distending pain caused by wind-cold cold. Magnolia Flower Bud mainly contains active ingredients such as lignans, flavonoids, alkaloids, and volatile oils; the medicinal property of Magnolia Flower Bud is light and ascending, which can warm and dredge the meridians, and its unique fragrant smell can open the nasal orifices, and has a significant effect on relieving nasal congestion and headache, especially suitable for the situation of wind-cold cold accompanied by nasal congestion.

[0015] Asarum: A cold-dispersing medicinal material that can warm the lungs to resolve fluid-retention, disperse wind and relieve pain, and is used to disperse cold and relieve pain, and can improve problems such as headache, nasal congestion of rhinitis, toothache, and joint pain caused by wind-cold cold. Asarum contains components such as lignans, volatile oils, and trace amounts of aristolochic acid I, etc. When using it, the dosage must be strictly controlled, and excessive use may cause physical discomfort.

[0016] Fried Xanthium sibiricum: It has the medicinal effects of dispersing wind pathogen, dredging nasal orifices, and dispelling wind and dampness. After being stir-fried, the toxicity of Xanthium sibiricum is greatly reduced, and it is a common nutritional tonic.

[0017] Poria: A traditional Chinese medicine that helps excrete excess water in the body, has the effects of eliminating edema, strengthening the spleen and promoting diuresis, calming the mind and promoting digestion, and is often used to treat problems such as body edema, reduced urination, poor appetite, and insomnia and dreaminess. Modern research found that Poria contains Poria polysaccharide, triterpenoid compounds, sterols, and also contains nutritional components such as protein, fat, and lecithin that helps brain development.

[0018] Angelica dahurica: A traditional Chinese medicinal herb for expelling wind and relieving pain, which can relieve cold headache, improve nasal congestion and runny nose, reduce toothache and skin swelling and redness. It can dispel cold in the body, improve discomfort in the head and face caused by wind-cold, and also has an adjuvant therapeutic effect on rhinitis and skin ulcer problems. Modern research has found that Angelica dahurica contains various active ingredients such as volatile oil, imperatorin, byak-angelicin, etc.

[0019] In the present invention, the traditional Chinese medicine preparation for treating rhinitis and sinusitis is an oral preparation.

[0020] Furthermore, the oral preparation is one of powder, granule, and mixture.

[0021] The preparation method of the powder is as follows: Weigh all raw material components by weight, adjust to an appropriate baking temperature and bake until the drug turns yellow, then crush and grind it into fine powder of 80 - 120 meshes, and pack it according to the packaging specifications.

[0022] Among them, the baking temperature is 90 - 110 °C, and the packaging specification is 60 - 70 g / bag, preferably 62 g / bag.

[0023] The preparation method of the granule is as follows: Weigh and soak the medicinal materials according to the ratio, then add them to the corresponding decoction extraction pots respectively, add water to submerge the medicinal materials, decoct twice, filter, combine the filtrates, concentrate, and then make the concentrated drugs into corresponding granules according to the preparation process of granules, and mix them in proportion when in use.

[0024] The preparation method of the mixture is as follows: Weigh and soak all the medicinal materials according to the ratio, then add them to the decoction extraction pot, add water to submerge the medicinal materials, decoct twice, filter, combine the filtrates, and boil them into concentrated medicine, then pack it.

[0025] In the present invention, the dosage of taking the traditional Chinese medicine preparation for treating rhinitis and sinusitis is twice a day, and the best time to take it is half an hour after lunch and half an hour before going to bed at night.

[0026] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0027] The traditional Chinese medicine preparation for treating rhinitis and sinusitis of the present invention uses refined materials, has small side effects, and has good curative effects on rhinitis, sinusitis, etc.; and the treatment time is short, and the symptoms of runny nose, nasal congestion, sneezing, and nasal itching of patients can be significantly improved after one week. Specific Embodiments

[0028] The following further illustrates the present invention with specific embodiments, but is not limited thereto. Any changes or improvements made based on the teachings of the present invention fall within the protection scope of the present invention.

[0029] All the traditional Chinese medicinal materials of the traditional Chinese medicine preparation for treating rhinitis and sinusitis of the present invention can be obtained through commercial channels.

[0030] Example 1

[0031] The traditional Chinese medicine preparation for treating rhinitis and sinusitis in this example is a powder. The dosages of each raw material are as follows: Ligusticum sinense 8 kg; Pogostemon cablin 7 kg; Morus alba root-bark 10 kg; Magnolia liliflora 10 kg; Asarum sieboldii 3 kg; Stir-fried Xanthium sibiricum 8 kg; Poria cocos 7 kg; Angelica dahurica 9 kg.

[0032] It is prepared by the following method: Weigh all raw material components by weight, bake until the color turns yellow, crush and grind them into fine powder of 80 - 120 meshes, and then pack them into bags according to the packaging specification of 70 g / bag.

[0033] Administration method: Twice a day, 70 g each time; The best time to take: Half an hour after lunch and half an hour before going to bed at night.

[0034] Example 2

[0035] The traditional Chinese medicine preparation for treating rhinitis and sinusitis in this example is a granule. The dosages of each raw material are as follows: Ligusticum sinense 9 kg; Pogostemon cablin 8 kg; Morus alba root-bark 8 kg; Magnolia liliflora 9 kg; Asarum sieboldii 3 kg; Stir-fried Xanthium sibiricum 9 kg; Poria cocos 8 kg; Angelica dahurica 8 kg.

[0036] It is prepared by the following method: Weigh the medicinal materials according to the ratio, soak them for 1 h, then add them to the corresponding decocting and extracting pots respectively, add water to submerge the medicinal materials, decoct twice, filter, combine the filtrates, concentrate, and then make the concentrated medicines into corresponding granules according to the preparation process of granules. When using, mix and brew them according to the ratio.

[0037] The preparation process of the granules is as follows: Cool the concentrated medicines to room temperature respectively, add ethanol, stir evenly, let it stand for more than 12 h to precipitate, take the supernatant, recover the ethanol, and then concentrate it to an extract with a relative density of 1.30 - 1.35 (measured at 60 °C) (moisture content 35%); Add powdered sugar, starch paste, binders, wetting agents and other auxiliary materials to make soft materials. The dosage of the auxiliary materials is 9 times the weight of the used extract. Then, through granulation, drying, and sieving, they are respectively packed into bags to become granules.

[0038] Generally, they are packed according to 9 g / bag of Ligusticum sinense granules, 8 g / bag of Pogostemon cablin granules, 8 g / bag of Morus alba root-bark granules, 9 g / bag of Magnolia liliflora granules, 3 g / bag of Asarum sieboldii granules, 9 g / bag of stir-fried Xanthium sibiricum granules, 8 g / bag of Poria cocos granules, and 8 g / bag of Angelica dahurica granules. When taking, open the bags and mix and brew them.

[0039] Administration method: Twice a day, mix and brew; The best time to take: Half an hour after lunch and half an hour before going to bed at night.

[0040] Example 3

[0041] The traditional Chinese medicine preparation for treating rhinitis and sinusitis in this embodiment is a mixture, and the dosages of each raw material are as follows: 12 kg of Ligusticum sinense Oliv.; 6 kg of Pogostemon cablin (Blanco) Benth.; 11 kg of Morus alba L. root bark; 7 kg of Magnolia officinalis Sieb. et Zucc. var. biloba (Rehd. et Wils.) Law; 4 kg of Asarum sieboldii Miq.; 7 kg of stir-fried Xanthium sibiricum Patrin ex Widd.; 6 kg of Poria cocos (Schw.) Wolf; 11 kg of Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav.

[0042] It is prepared by the following method: After soaking all the medicinal materials for 1 hour, add them to a decoction extraction pot, add water to submerge the medicinal materials, decoct twice, filter, and concentrate the two filtrates to 1000 ml. The concentrated solution contains 0.64 g / ml of crude drug content.

[0043] Dosage method: Take 100 ml twice a day; The best time to take it: Half an hour after lunch and half an hour before going to bed at night.

[0044] Clinical trials

[0045] I. Clinical data

[0046] Randomly select 100 patients with rhinitis and 100 patients with sinusitis, among which 50% are male and 50% are female.

[0047] II. Treatment method

[0048] All take the granule of the traditional Chinese medicine preparation for treating rhinitis and sinusitis prepared in Example 2 of the present invention, and take it according to the dosage method in Example 2. Two consecutive weeks are taken as a course of treatment.

[0049] III. Evaluation of treatment effect

[0050] a. Cured

[0051] After taking for one week, the symptoms of runny nose, nasal congestion, sneezing, and nasal itching are significantly improved; After taking for one course of treatment, there are no symptoms of runny nose, nasal congestion, sneezing, and nasal itching.

[0052] b. Effective

[0053] After taking for one week, the symptoms of runny nose, nasal congestion, sneezing, and nasal itching are improved; After taking for one course of treatment, the symptoms of runny nose, nasal congestion, sneezing, and nasal itching are significantly improved.

[0054] c. Ineffective

[0055] After one course of treatment, there are still symptoms such as runny nose, nasal congestion, sneezing, and nasal itching.

[0056] According to the above treatment method, record the treatment effect in Table 1.

[0057] Table 1 Evaluation of the treatment effect of patients with rhinitis and sinusitis

[0058]

[0059] According to the results in Table 1, it can be seen that: evaluated according to the above treatment method and curative effect evaluation criteria, the treatment results are basically within the effective range, the effective rate is as high as 99%, and most patients have a short recovery time when using this product, and the symptoms of runny nose, nasal congestion, sneezing, and nasal itching are significantly improved after one week, indicating that the traditional Chinese medicine preparation for treating rhinitis and sinusitis of the present invention has good medicinal effects.

Claims

1. A Chinese medicine preparation for treating rhinitis and sinusitis, characterized in that Contains the following Chinese medicinal material raw material components by weight:

2. The Chinese medicine preparation for treating rhinitis and sinusitis according to claim 1, characterized in that Contains the following Chinese medicinal material raw material components by weight:

3. The Chinese medicine preparation for treating rhinitis and sinusitis according to claim 1 or 2, characterized in that The traditional Chinese medicine preparation for treating rhinitis and sinusitis is an oral preparation.

4. The Chinese medicine preparation for treating rhinitis and sinusitis according to claim 3, characterized in that The oral preparation is one of powder, granule and mixture.

5. The Chinese medicinal preparation for treating rhinitis and sinusitis according to claim 4, characterized in that The preparation method of the powder is as follows: all raw material components are weighed by weight, adjusted to a suitable baking temperature and baked until the drug turns yellow, crushed and ground into 80-120 mesh fine powder, and packaged according to packaging specifications.

6. The Chinese medicinal preparation for treating rhinitis and sinusitis according to claim 5, characterized in that The baking temperature is 90-110° C., and the packaging specification is 60-70 g / bag.

7. The Chinese medicinal preparation for treating rhinitis and sinusitis according to claim 4, characterized in that The preparation method of the granules is as follows: the medicinal materials are weighed and soaked according to the proportion, and then added into the corresponding decoction and extraction pots, water is added to soak the medicinal materials, decocted twice, filtered, the filtrate is combined, concentrated, and then the concentrated drugs are made into corresponding granules according to the preparation process of the granules, and mixed and brewed according to the proportion when used.

8. The Chinese medicinal preparation for treating rhinitis and sinusitis according to claim 4, characterized in that The preparation method of the mixture is as follows: all medicinal materials are weighed and soaked according to the proportion, and then added into a decoction and extraction pot, water is added to soak the medicinal materials, decocted twice, filtered, the filtrate is combined, and after boiling into concentrated medicine, it can be packaged.

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