Deodorizing method and deodorizing agent for extracting solution of oral liquid containing cervus elaphus linnaeus

Abstract

The invention provides a deodorizing method of an oral liquid extract containing cervus elaphus linnaeus and a deodorizing agent, and relates to the technical field of deodorizing of traditional Chinese medicine liquid preparations. The deodorizing agent is composed of carbon dioxide gas and nitrogen gas, the carbon dioxide gas accounts for 30%-50% of the weight of the deodorizing agent, and the nitrogen gas accounts for 50%-70% of the weight of the deodorizing agent. According to the invention, the deodorizing agent formed by mixing carbon dioxide and nitrogen is adopted, and the bad smell in the oral liquid extracting solution containing cervus elaphus linnaeus is removed in a relatively low-temperature and micro-vacuum environment and a matched deodorizing device. By adopting the deodorizing method disclosed by the invention, fishy smell substance residues of the cervus elaphus linnaeus-containing extracting solution are remarkably reduced, active ingredients are not lost, and the quality of the oral liquid is remarkably improved.

Description

Technical Field

[0001] The invention belongs to the technical field of deodorization of traditional Chinese medicine liquid preparations, and particularly relates to a deodorization method and a deodorizing agent for an oral liquid extract containing red deer antler. Background Art

[0002] Animal-derived medicinal materials such as red deer antlers contain volatile amines, such as pyrazine compounds, which cause a significant fishy smell and restrict patient compliance. In addition, red deer antler extracts are often mixed with some volatile small molecules, which usually have an unpleasant smell. The presence of these volatile small molecules seriously affects the quality of the product. In response to these problems, the industry generally uses solid adsorption and filtration technologies, such as nanofiltration, deodorization or ion exchange adsorption and elution methods, to remove the odorous substances in the red deer antler extract in steps to solve the problem that the fishy smell in the extracted liquid is difficult to remove. These physical adsorption technologies usually require complex equipment with high equipment requirements, and the operation steps are cumbersome, time-consuming and labor-intensive, and the adsorption effect is often unsatisfactory; on the other hand, after the deodorization and deodorization process is completed, the adsorption material used must be eluted, balanced, and regenerated for next use, which invisibly increases the production and manufacturing costs.

[0003] Steam is the most commonly used stripping gas in the deodorization process. However, when steam is used as a stripping gas for deodorization and deodorization, the high temperature during use will hydrolyze the materials in the deodorization and deodorization system, causing the loss of the effective ingredients or nutrients that are intended to be retained. Therefore, it is difficult to obtain high-quality, stable-performance products when steam is used for deodorization and deodorization.

[0004] Nitrogen has unique characteristics as a stripping gas for deodorizing animal and plant extracts. Yu Dianyu et al. used nitrogen to deodorize evening primrose oil and studied the effect of nitrogen on the peroxide value of evening primrose oil during the deodorization process; Zheng Shumin et al. studied the effect of nitrogen on the phytosterol content in corn oil during the deodorization process. However, the stripping conditions they studied were all carried out at high temperature (110℃~260℃) and long time (180~240min).

[0005] In summary, how to ensure good deodorization effect while ensuring high quality and stable performance of red deer antler oral liquid extract, simple deodorization equipment and operation steps, and saving time and labor is a technical problem that needs to be solved urgently in this field. Summary of the invention

[0006] In view of this, the object of the present invention is to provide a deodorizing method and a deodorizing agent for an oral liquid extract containing red deer antler. The deodorizing agent and the deodorizing method of the present invention can significantly remove the unpleasant odor in the oral liquid extract containing red deer antler, improve the quality of the oral liquid, save time and effort, and reduce costs.

[0007] The present invention provides a deodorant, which is composed of carbon dioxide gas and nitrogen gas. The carbon dioxide gas accounts for 30% - 50% of the weight ratio of the deodorant, and the nitrogen gas accounts for 50% - 70% of the weight ratio of the deodorant.

[0008] The present invention also provides a method for deodorizing an oral liquid extract containing pilose antler of Cervus elaphus, comprising the following steps: introducing the deodorant described in claim 1 from the bottom of the deodorizing device, and extracting the deodorant from the top of the deodorizing device to deodorize the oral liquid extract containing pilose antler of Cervus elaphus; during deodorization, the temperature inside the deodorizing device is 40°C - 60°C, and the vacuum degree is -0.05 Pa - -0.08 Pa.

[0009] Preferably, during deodorization, the input rate of the deodorant is 0.5 - 0.8 liters per minute; the oral liquid extract containing pilose antler of Cervus elaphus includes Ganoderma lucidum, American ginseng, wolfberry fruit, polygonatum sibiricum, and pilose antler of Cervus elaphus.

[0010] Preferably, the mass ratio of Ganoderma lucidum, American ginseng, wolfberry fruit, polygonatum sibiricum, and pilose antler of Cervus elaphus is 1:1:1.2:(1.5 - 1.6):(0.17 - 0.34).

[0011] Preferably, before deodorizing the oral liquid extract containing pilose antler of Cervus elaphus, the temperature of the extract in the deodorizing device is controlled at 40 - 60°C and stabilized for 20 - 40 minutes.

[0012] Preferably, the introduction and extraction of the deodorant are carried out simultaneously.

[0013] The present invention also provides a deodorizing device based on the above deodorizing method, which is characterized in that it includes a deodorizing tank (1), a gas mixing tank (2), a continuous temperature control jacket (3), a screw vacuum pump unit (4), a cooling tower (5), and a cooling water tank (6);

[0014] The top of the deodorizing tank (1) is provided with an extract inlet (7) and a mixed waste gas exhaust port (8), and the bottom of the deodorizing tank (1) is provided with a mixed gas inlet (9) and an extract outlet (10); a servo motor (11) is installed at the center position on the outer side of the top of the deodorizing tank (1), a stirring shaft (12) is fixedly installed on the servo motor (11), the stirring shaft (12) is arranged inside the deodorizing tank (1), and 4 - 6 stirring blades (13) are arranged on the outer wall of the stirring shaft (12);

[0015] The continuous temperature control jacket (3) is coated on the outer wall of the deodorizing tank (1);

[0016] The gas mixing tank (2) is provided with a carbon dioxide gas source inlet (16), a nitrogen gas source inlet (17) and a mixed gas outlet (18). The mixed gas outlet (18) is connected to the mixed gas inlet (9) through a connecting pipe. A first control valve (19) is provided at the connection between the connecting pipe and the mixed gas inlet 9 for controlling the flow rate of the mixed gas and sealing the deodorization tank (1).

[0017] The screw vacuum pump unit (4) is connected to the mixed waste gas exhaust port (8). The cooling tower 5 is connected to the screw vacuum pump unit 4 through a pipe. The cooling water tank 6 is connected to the cooling tower 5 through a pipe.

[0018] The present invention also provides an application of the deodorant, the deodorization method or the deodorization device in removing the odor of animal-derived extract liquid.

[0019] Preferably, the animal-derived extract liquid is an extract liquid containing pilose antler.

[0020] Preferably, the extract liquid containing pilose antler is the oral liquid extract liquid containing pilose antler.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] The deodorization method for the oral liquid extract liquid containing pilose antler provided by the present invention removes the peculiar smell in the oral liquid extract liquid containing pilose antler by adopting a deodorant composed only of a mixture of carbon dioxide and nitrogen, a relatively low temperature + micro-vacuum environment and a supporting deodorization device. By using the deodorization method of the present invention, the residual fishy substances in the pilose antler extract liquid are significantly reduced, and the content of active ingredients in the product is not affected, and the quality of the oral liquid is significantly improved. In addition, the operation steps of the present invention are simple, the deodorization time is short, it saves time and effort, and reduces costs. Description of the Drawings

[0023] Figure 1 It is a schematic diagram of the deodorization device in Embodiment 1, wherein: 1 - deodorization tank, 2 - gas mixing tank, 3 - continuous temperature control jacket, 4 - screw vacuum pump unit, 5 - cooling tower, 6 - cooling water tank, 7 - extract liquid inlet, 8 - mixed waste gas exhaust port, 9 - mixed gas inlet, 10 - extract liquid outlet, 11 - servo motor, 12 - stirring shaft, 13 - stirring blade, 14 - feed valve, 15 - discharge valve, 16 - carbon dioxide gas source inlet, 17 - nitrogen gas source inlet, 18 - mixed gas outlet, 19 - first control valve, 20 - second control valve, 21 - third control valve. Detailed Embodiments

[0024] The present invention provides a deodorant, which is composed of carbon dioxide gas and nitrogen gas. The carbon dioxide gas accounts for 30% to 50% of the weight of the deodorant, and the nitrogen gas accounts for 50% to 70% of the weight of the deodorant.

[0025] In the present invention, when using the deodorant, as an optional implementation manner, the carbon dioxide gas accounts for 50% in the deodorant composed of the carbon dioxide gas and the nitrogen gas, and the nitrogen gas accounts for 50% in the deodorant composed of the carbon dioxide gas and the nitrogen gas. As another optional implementation manner, the carbon dioxide gas accounts for 30% in the deodorant composed of the carbon dioxide gas and the nitrogen gas, and the nitrogen gas accounts for 70% in the deodorant composed of the carbon dioxide gas and the nitrogen gas.

[0026] The present invention also provides a method for deodorizing an oral liquid extract containing pilose antler of Cervus elaphus, which includes the following steps: introducing the deodorant described in claim 1 from the bottom of the deodorizing device, and extracting the deodorant from the top of the deodorizing device to deodorize the oral liquid extract containing pilose antler of Cervus elaphus; during deodorization, the temperature in the deodorizing device is 40°C to 60°C, and the vacuum degree is -0.05 Pa to -0.08 Pa.

[0027] In the present invention, deodorants composed of carbon dioxide gas and nitrogen gas with different weight ratios are applicable to deodorization under different weight ratio formulations of the oral liquid extract containing pilose antler of Cervus elaphus. As an implementable manner, when the weight ratio of the formulation of the oral liquid extract containing pilose antler of Cervus elaphus is Ganoderma lucidum: American ginseng: Chinese wolfberry: Polygonatum sibiricum: freeze-dried pilose antler of Cervus elaphus = 1:1:1.2:1.6:0.17, the weight ratio of nitrogen to carbon dioxide in the deodorant is 1:1, that is, the weight content of nitrogen is 50%, and the weight content of carbon dioxide is 50%. As another implementable manner, when the weight ratio of the formulation of the oral liquid extract containing pilose antler of Cervus elaphus is Ganoderma lucidum: American ginseng: Chinese wolfberry: Polygonatum sibiricum: freeze-dried pilose antler of Cervus elaphus = 1:1:1.2:1.5:0.34, the weight ratio of nitrogen to carbon dioxide in the deodorant is 7:3, that is, the weight content of nitrogen is 70%, and the weight content of carbon dioxide is 30%. In the present invention, the deodorant can carry away the odor substances in the oral liquid extract containing pilose antler of Cervus elaphus to achieve the purpose of deodorization.

[0028] In the present invention, the temperature for deodorizing the oral liquid extract containing pilose antler of Cervus elaphus is preferably 48°C to 58°C, and more preferably 55°C; the vacuum degree is preferably 0.05 Pa to 0.06 Pa or -0.06 Pa to -0.07 Pa or -0.07 Pa to -0.08 Pa, and more preferably -0.05 Pa, -0.055 Pa, -0.06 Pa, -0.065 Pa, -0.07 Pa, -0.075 Pa or -0.08 Pa.

[0029] In the present invention, during deodorization, the input rate of the deodorant is 0.5 - 0.8 liters per minute; preferably 0.5 - 0.6 liters per minute or 0.6 - 0.7 liters per minute or 0.7 - 0.8 liters per minute. As an implementable mode, during deodorization, the input rate of the deodorant is 0.66 liters per minute.

[0030] In the present invention, when the deodorant is introduced into the deodorization device and comes into contact with the oral liquid extract containing pilose antler for deodorization, stirring is carried out. The rotation speed of the stirring is preferably 20 - 40 rpm, and more preferably 30 rpm.

[0031] In the present invention, before deodorizing the oral liquid extract containing pilose antler, the temperature of the extract in the deodorization device is controlled at 40 - 60 °C and stabilized for 20 - 40 minutes; preferably, the temperature is controlled at 45 °C and stabilized for 30 minutes.

[0032] In the present invention, the introduction and extraction of the deodorant are carried out simultaneously, and the deodorization process takes 40 - 50 minutes.

[0033] In the present invention, the oral liquid extract containing pilose antler preferably includes ganoderma lucidum, american ginseng, wolfberry fruit, polygonatum sibiricum, and pilose antler, and the mass ratio of ganoderma lucidum, american ginseng, wolfberry fruit, polygonatum sibiricum, and pilose antler is 1:1:1.2:(1.5 - 1.6):(0.17 - 0.34). Ganoderma lucidum, american ginseng, wolfberry fruit, polygonatum sibiricum, and pilose antler are used as the main components.

[0034] The deodorization method of the oral liquid extract containing pilose antler in the present invention removes the peculiar smell in the oral liquid extract containing pilose antler by using the deodorant, a relatively low temperature + slightly vacuum environment, and a supporting deodorization device. The principle of the deodorization method in the present invention is to control the inside of the deodorization device to be in a slightly vacuum or low vacuum state under a relatively low temperature condition of 40 °C - 60 °C during deodorization, creating a pressure difference, and the deodorant composed of nitrogen and carbon dioxide gases strips and removes the odor substances gas in the oral liquid extract containing pilose antler. Using the deodorization method of the present invention significantly reduces the residual fishy substances in the oral liquid extract containing pilose antler. After quality inspection, there is no peculiar smell at all. The deodorization process will not affect the content of the active ingredients in the product. The product labeling ingredient index: the content of total saponins (calculated as ginsenoside Re) is 0.56 g / 100 mL, which significantly improves the quality of the oral liquid. In addition, the operation steps of the present invention are simple, the deodorization time is short, only 40 - 50 minutes are required, which saves time and effort and reduces costs.

[0035] The present invention provides a deodorization device supporting the deodorization method, which is composed of a deodorization main system, a gas mixing system, a vacuum pumping and discharging system, a temperature control system, and an exhaust gas condensation system. As Figure 1 shown, it includes a deodorization tank, a gas mixing tank, a continuous temperature control jacket, a screw vacuum pump unit, a cooling tower, and a cooling water tank;

[0036] The top of the deodorization tank is provided with an extraction liquid inlet and a mixed waste gas exhaust port, and the bottom of the deodorization tank is provided with a mixed gas inlet and an extraction liquid outlet; a servo motor is installed at the center position of the top of the deodorization tank, and the output end of the servo motor is fixedly installed with a stirring shaft. The stirring shaft penetrates and extends into the interior of the deodorization tank, and 4 stirring blades are arranged on the outer wall of the stirring shaft;

[0037] The continuous temperature control jacket is wrapped around the outer wall of the deodorization tank;

[0038] The gas mixing tank is provided with a carbon dioxide gas source inlet, a nitrogen gas source inlet and a mixed gas outlet. The mixed gas outlet is connected to the mixed gas inlet through a connecting pipe, and a first control valve is arranged on the connecting pipe to control the flow rate of the mixed gas and seal the deodorization tank;

[0039] The screw vacuum pump unit is connected to the mixed waste gas exhaust port, the cooling tower is connected to the screw vacuum pump unit through a pipe, and the cooling water tank is connected to the cooling tower through a pipe.

[0040] In the present invention, the servo motor in the deodorization tank is used to control the stirring rate.

[0041] In the present invention, a feed valve is arranged at the extraction liquid inlet, and a discharge valve is arranged at the extraction liquid outlet. In the present invention, the feed valve can control the input of the extraction liquid and can play a role in sealing the tank body when it is closed. The discharge valve can control the output of the extraction liquid and can play a role in sealing the tank body when it is closed.

[0042] In the present invention, the continuous temperature control jacket is wrapped on the outer wall of the deodorization tank, and the continuous temperature control jacket is used to control the temperature in the deodorization tank, and the temperature in the tank can be stably controlled within the range of 40°C to 60°C.

[0043] In the present invention, the gas mixing tank is used to mix nitrogen and carbon dioxide according to a preset ratio, and then output the mixture to the deodorization tank through the mixed gas outlet connected to the mixed gas inlet through the connecting pipe. The first control valve on the connecting pipe has dual functions: on the one hand, it can control the input of the mixed gas from the gas mixing tank to the deodorization tank, ensuring that the mixed gas is continuously and accurately input into the deodorization tank at a stable flow rate to meet the strict requirements of the deodorization process of the oral liquid extraction liquid containing pilose antler velvet for the input amount of the mixed gas; on the other hand, when the first control valve is in the closed state, it can effectively seal the deodorization tank and prevent the leakage of the mixed gas.

[0044] In the present invention, the screw vacuum pump unit is used to maintain a slight vacuum in the tank and extract the mixed waste gas after deodorization; the screw vacuum pump unit is used on the one hand to ensure that the deodorization tank is in a slight vacuum state of -0.05Pa to -0.08Pa during the deodorization process; on the other hand, it ensures that the mixed gas of carbon dioxide and nitrogen after deodorization is extracted after the deodorization is completed.

[0045] In the present invention, the carbon dioxide gas source inlet is connected to the carbon dioxide gas source, and the nitrogen gas source inlet is connected to the nitrogen gas source; the carbon dioxide gas source inlet is provided with a second control valve, and the nitrogen gas source inlet is provided with a third control valve; the second control valve and the third control valve are respectively used to control the on-off, flow rate and intake pressure of carbon dioxide or nitrogen, and adjust the ratio of carbon dioxide and nitrogen output to the gas mixing tank, and the weight ratio of carbon dioxide and nitrogen is 50% to 30%: 50% to 70%. In the present invention, the second control valve and the third control valve can accurately adjust the ratio of carbon dioxide and nitrogen input into the gas mixing tank, and meet the specific requirements for the composition of the mixed gas in the deodorization process of the oral liquid extract containing red deer antler.

[0046] In the present invention, the mixed gas of carbon dioxide and nitrogen after deodorization extracted by the screw vacuum pump unit is then emptied to the cooling tower through a pipeline. After the mixed exhaust gas enters the cooling tower, it is fully in contact with the air entering from the bottom or the side in the packing layer, and the heat is transferred to the air. The mixed exhaust gas is gradually cooled and condensed into water droplets. The condensed water droplets fall to the water collection tray at the bottom of the cooling tower under the action of gravity, and the condensed water flows back to the cooling water tank through the pipeline for storage.

[0047] The present invention also provides the use of the deodorant, the deodorant method or the deodorant device in removing the fishy smell of an animal-derived extract. In the present invention, the animal-derived extract is an extract containing red deer antler. As an implementation method, the extract containing red deer antler is the oral liquid extract containing red deer antler prepared by the extraction method of the oral liquid extract containing red deer antler in the present invention.

[0048] The "relatively low temperature" mentioned in the present invention refers to 40°C to 60°C.

[0049] In order to further illustrate the present invention, the deodorant, the deodorizing method, the device and the application of the present invention are described in detail below with reference to the accompanying drawings and examples, but they should not be construed as limiting the scope of protection of the present invention.

[0050] Unless otherwise specified, the experimental methods used in the following examples are all conventional methods; the materials and reagents used are all reagents and materials that can be obtained from commercial channels unless otherwise specified.

[0051] Example 1

[0052] The preparation method of the extract of the oral liquid containing pilose antler of Cervus elaphus includes the following steps:

[0053] 1). First, freeze the harvested pilose antler of Cervus elaphus at -25°C for 48 hours, take it out, and thaw naturally for 4 hours;

[0054] 2). Use a shaving knife to shave off the fur of the pilose antler of Cervus elaphus. There is pilose antler blood oozing out on the surface of the fresh pilose antler after peeling.

[0055] 3). Then, perform secondary freezing for 24 hours. After the second freezing is completed, take it out, use a self-made slicing machine (horseback type electric pilose antler slicing machine) to slice the pilose antler blood slices about 2 mm thick, and then freeze-dry to obtain the dried pilose antler blood slices.

[0056] Then, prepare the extract of the oral liquid containing pilose antler of Cervus elaphus:

[0057] Formula A: 1000 g of American ginseng, 1000 g of Ganoderma lucidum, 1200 g of wolfberries, 170 g of pilose antler of Cervus elaphus, and 1600 g of polygonatum sibiricum; 120 g of xylitol, 4 g of potassium sorbate, and 2 g of stevioside. Use purified water as the solvent for volume fixation to 10000 mL.

[0058] Preparation plan:

[0059] (1) Pretreatment

[0060] Pick out impurities from the Chinese herbal medicine pieces of Ganoderma lucidum, American ginseng, wolfberries, pilose antler of Cervus elaphus, and polygonatum sibiricum that meet the requirements, weigh them, and set aside. After passing the inspection of xylitol, stevioside, and potassium sorbate, remove the outer packaging and enter the clean area for standby.

[0061] (2) Extraction, filtration, and deodorization

[0062] Extraction: After soaking Ganoderma lucidum, American ginseng, wolfberries, pilose antler of Cervus elaphus, and polygonatum sibiricum for 2 hours, place them in an extraction tank, mix them in the tank, with a rotation speed of 35 rpm, control the temperature at 45°C, control the ultrasonic frequency at 20 kHz and 2500 W; after mixing, perform ultrasonic extraction. The temperature in the tank is 45°C, the ultrasonic power is 3000 W / unit × 4 units, the pressure is -0.08 Pa, the rotation speed of the stirrer is 25 rpm, and extract for 2.5 hours to obtain the original extract containing pilose antler of Cervus elaphus;

[0063] Filtration: Filter the original extract containing pilose antler of Cervus elaphus through a 100-mesh filter to obtain the extract of the oral liquid containing pilose antler of Cervus elaphus.

[0064] Deodorization: A deodorization method for the extract of the oral liquid containing pilose antler of Cervus elaphus includes the following steps:

[0065] (1) Input 800 kg of the oral liquid extract containing pilose antler of red deer prepared above into a deodorizing tank, heat it with a jacket to control the temperature of the extract in the tank at 45 °C, and keep it stable for 30 minutes;

[0066] (2) Pass a mixed gas composed of nitrogen and carbon dioxide as a deodorant into the deodorizing tank from the bottom of the deodorizing tank. The weight ratios of nitrogen and carbon dioxide are both 50%, and the input rate is 0.66 L / min. Contact with the extract in the tank, and at the same time start the stirring device to stir and deodorize. The stirring speed is 30 rpm. Keep the tank at a slight vacuum of -0.08 Pa and a temperature of 55 °C; Draw out the mixed waste gas of nitrogen and carbon dioxide that has stripped the fishy smell of the oral liquid extract containing pilose antler of red deer from the top of the deodorizing tank; The input and extraction of the deodorant are carried out simultaneously, and the whole deodorizing process takes 40 minutes.

[0067] (3) After the deodorization reaction is completed, obtain the deodorized oral liquid extract containing pilose antler of red deer.

[0068] Example 2

[0069] Carry out the steps of vacuum concentration, drying into paste powder and preparing the liquid to prepare the oral liquid containing pilose antler of red deer from the deodorized oral liquid extract containing pilose antler of red deer in Example 1.

[0070] (1) Vacuum concentration:

[0071] The operating temperature is 50 °C, the vacuum degree is -0.8 Pa, concentrate until the water content is 10%, and the relative density is 1.05 - 1.10 (60 °C) to obtain a concentrated solution for standby.

[0072] (2) Drying into paste powder:

[0073] The pre-cooling temperature is -18 °C, the cold trap temperature is -22 °C, the vacuum degree is -0.1 Pa, the freezing time is 22 h, and the sublimation temperature is 18 °C.

[0074] (3) Preparing the liquid:

[0075] Standing: After dissolving the dried paste powder, let it stand and take the supernatant. Filter the supernatant through a 100-mesh sieve to obtain Solution A.

[0076] Weighing: Weigh xylitol, stevioside, and potassium sorbate respectively according to the formula amounts in Formula A for standby;

[0077] Dissolving and sieving: Add appropriate purified water to the formula amounts of xylitol and stevioside, stir and dissolve, and pass through a 100-mesh sieve to obtain Solution B for standby. Add appropriate purified water to the formula amount of potassium sorbate, stir and dissolve, and pass through a 100-mesh sieve to obtain Solution C for standby;

[0078] Volume fixing and mixing: Put Solution A, Solution B, and Solution C into a liquid preparation tank, add purified water to fix the volume to the formula amount in Formula A, mix for 20 min, and filter to obtain the oral liquid containing pilose antler of red deer.

[0079] (4) Washing the bottles and bottle caps

[0080] The oral liquid bottles are washed with drinking water and purified water in sequence, dried, and reserved; the oral liquid bottle caps are washed with drinking water and purified water in sequence, soaked in 75% ethanol, air-dried, and reserved.

[0081] (5) Filling and capping

[0082] The qualified oral liquid stock solution is filled on an oral liquid filling and capping machine, with the filling volume of 10 mL per vial, capped, and the sealing performance is inspected. The inner packaging material is a sodium calcium glass controlled oral liquid bottle, and the standard complies with the requirements of Sodium Calcium Glass Controlled Oral Liquid Bottle YBB00032004.

[0083] (6) Sterilization

[0084] The filled products are placed in a sterilizer for sterilization. Heat-pressure sterilization is adopted, with the temperature of 115 °C, the pressure of 68.6 KPa, and the sterilization time of 30 min.

[0085] (7) Lamp inspection, packaging, labeling, finished product inspection, and warehousing

[0086] The sterilized oral liquid is inspected under a lamp inspection lamp, and the unqualified products such as insufficient filling volume, loose sealing, breakage, and foreign matters are removed. The lamp-inspected qualified products are packed into packaging boxes according to the specifications, 10 vials per box, and labeled. A batch of samples is randomly selected and inspected as finished products according to the methods and requirements described in the quality standard of this product. After passing the inspection, they are warehoused.

[0087] (8) Cleanliness requirements for the production environment and hygiene

[0088] The production environment and management shall comply with the requirements of Good Manufacturing Practice for Health Food. During production, processes such as liquid preparation (standing, weighing, dissolving, sieving, volume fixing, mixing), washing the bottles and bottle caps with purified water, filling, and capping are all operated under the conditions of a 100,000-class production clean area, and the others are carried out in the general production area.

[0089] Test examples

[0090] The products prepared in Example 2 are randomly sampled and entrusted to Nanjing Product Quality Supervision and Inspection Institute, Nanjing Institute of Quality Development and Advanced Technology Application for testing. The determination is carried out in accordance with the enterprise standard Q / XYSY 0018S-2024, and the test reports with the report numbers of NZJ(2024)JK01-10341Z (see Table 2) and NZJ(2024)JK01-10342Z (see Table 1) are obtained. The specific test results are as follows:

[0091] Table 1 Detection results of the labeled components of the oral liquid raw liquid containing pilose antler

[0092]

[0093] Table 2 Determination Results of Sensory, Physical and Chemical, and Microbiological Indicators of the Raw Material Liquid of Oral Liquid Containing Pilose Antler

[0094]

[0095]

[0096] After testing, the oral liquid prepared from pilose antler after deodorization has the taste and smell it should have, without peculiar smell. The test result of the labeled ingredient shows that the content of total saponins (calculated as ginsenoside Re) is 0.56 g / 100 mL.

[0097] Example 3

[0098] The preparation method of the extraction liquid of oral liquid containing pilose antler used in the following examples includes the following steps:

[0099] 1). First, freeze the harvested pilose antler at -25 °C for 48 h, take it out, and thaw naturally for 4 h;

[0100] 2). Use a knife to shave off the fur of the pilose antler. There is pilose antler blood oozing out on the surface of the peeled fresh pilose antler;

[0101] 3). Then conduct secondary freezing for 24 h. After the second freezing is completed, take it out, use a self-made slicing machine (horseback-type electric pilose antler slicing machine) to slice the pilose antler blood slices about 2 mm thick, and then freeze-dry to obtain dry pilose antler blood slices.

[0102] Then prepare the extraction liquid of oral liquid containing pilose antler:

[0103] In this example, when preparing the extraction liquid of oral liquid containing pilose antler and polygonatum sibiricum, Formula B is adopted.

[0104] Formula B is: 1000 g of American ginseng, 1000 g of ganoderma lucidum, 1200 g of wolfberries, 340 g of pilose antler, and 1500 g of polygonatum sibiricum; 120 g of xylitol, 4 g of potassium sorbate, and 2 g of stevioside. Use purified water as the solvent for volume fixation to 10000 mL.

[0105] Preparation plan:

[0106] (1) Pretreatment

[0107] Pick out the impurities from the qualified traditional Chinese medicine pieces of ganoderma lucidum, American ginseng, wolfberries, pilose antler, and polygonatum sibiricum, weigh them, and set aside. After passing the inspection of xylitol, stevioside, and potassium sorbate, remove the outer packaging and enter the clean area for standby.

[0108] (2) Extraction, filtration, and deodorization

[0109] Extraction: After soaking Ganoderma lucidum, American ginseng, wolfberry fruits, pilose antler, and polygonatum sibiricum for 2 hours, place them in an extraction tank, mix them in the tank at a rotation speed of 40 rpm, control the temperature at 50 °C, and control the ultrasonic frequency at 20 kHz and 2500 W; after mixing, perform ultrasonic extraction, with the temperature in the tank at 40 °C, ultrasonic power of 2000 W per unit × 4 units, pressure of -0.05 Pa, stirrer rotation speed of 25 rpm, and extract for 2.5 hours to obtain the original extract containing pilose antler.

[0110] Filtration: Filter the original extract containing pilose antler through a 100-mesh filter to obtain the extract for oral liquid containing pilose antler.

[0111] Deodorization: A method for deodorizing the extract for oral liquid containing pilose antler, comprising the following steps:

[0112] (1) Pass 800 kg of the above-mentioned extract for oral liquid containing pilose antler into the deodorization tank, heat it with a jacket to control the temperature of the extract in the tank at 55 °C, and keep it stable for 30 minutes;

[0113] (2) Pass a mixed gas composed of nitrogen and carbon dioxide as a deodorant into the deodorization tank from the bottom of the deodorization tank, with the weight ratio of nitrogen to carbon dioxide N2:CO2 = 70%:30%, input rate of 0.7 liters per minute, contact with the extract in the tank, and at the same time start the stirring device to stir and remove the fishy smell, with the stirring rotation speed of 30 rpm. Keep the inside of the tank at a slightly negative pressure of -0.06 Pa and a temperature of 45 °C; draw out the mixed waste gas of nitrogen and carbon dioxide that has stripped the fishy smell of the extract for oral liquid containing pilose antler from the top of the deodorization tank; the input and extraction of the deodorant are carried out simultaneously, and the whole deodorization process takes 50 minutes.

[0114] (3) After the deodorization reaction is completed, obtain the deodorized extract for oral liquid containing pilose antler.

[0115] The extract for oral liquid containing pilose antler after the above deodorization is prepared into an oral liquid product containing pilose antler (according to formula B) through steps such as vacuum concentration, drying into paste powder, and liquid preparation in Example 2. After testing, it has the expected taste and smell of the product, no abnormal smell, and the test result of the labeled ingredient shows that the content of total saponins (calculated as ginsenoside Re) is ≥ 0.03 g / 100 mL.

[0116] Example 4

[0117] A method for deodorizing the extract for oral liquid containing pilose antler, the difference between this method and Example 1 is that the input rate of nitrogen and carbon dioxide is 0.8 liters per minute, keep the inside of the tank at a slightly negative pressure of -0.07 Pa and a temperature of 60 °C; the whole fishy smell removal process takes 50 minutes.

[0118] The oral liquid product of pilose antler of Cervus elaphus is prepared by subjecting the oral liquid extract of pilose antler of Cervus elaphus after the above-mentioned deodorization to the steps of vacuum concentration, drying into paste powder and preparing the liquid in Example 2. After testing, it has the taste and smell that the product should have, without peculiar smell, and the test result of the labeled ingredient shows that the content of total saponins (calculated as ginsenoside Re) ≥ 0.03 g / 100 mL.

[0119] Example 5

[0120] The deodorization device for supporting the above deodorization method: as Figure 1 shown, it includes a deodorization tank 1, a gas mixing tank 2, a continuous temperature control jacket 3, a screw vacuum pump unit 4, a cooling tower 5 and a cooling water tank 6.

[0121] At the top of the deodorization tank 1, an extract inlet 7 and a mixed exhaust gas outlet 8 are provided.

[0122] At the bottom of the deodorization tank 1, a mixed gas inlet 9 and an extract outlet 10 are provided.

[0123] A servo motor 11 is installed at the outer middle position at the top of the deodorization tank 1. The output end of the servo motor 11 is fixedly installed with a stirring shaft 12 arranged inside the deodorization tank 1. Stirring blades 13 are arranged on the outer wall of the stirring shaft 12, and there are 4 stirring blades 13. The servo motor 11 is used to control the stirring rate.

[0124] The outer wall of the deodorization tank 1 is covered with a continuous temperature control jacket 3, and the continuous temperature control jacket 3 is used to control the temperature in the deodorization tank 1, so that the temperature in the tank can be stably controlled within the range of 40°C to 60°C.

[0125] A feed valve 14 is provided at the extract inlet 7, which can control the input of the extract and can play a role in sealing the tank body when closed. A discharge valve 15 is provided at the extract outlet 10, which can control the output of the extract and can play a role in sealing the tank body when closed.

[0126] The gas mixing tank 2 is provided with a carbon dioxide gas source inlet 16, a nitrogen gas source inlet 17 and a mixed gas outlet 18, which is used to mix nitrogen and carbon dioxide in a preset ratio, and then output the mixed gas to the deodorization tank 1 through the mixed gas outlet 18 via a connecting pipe connected to the mixed gas inlet 9;

[0127] A first control valve 19 is provided at the connection between the connecting pipe and the mixed gas inlet 9. The first control valve 19 has dual functions: on the one hand, it can control the passage of the mixed gas from the gas mixing tank 2 to the deodorization tank 1, ensuring that the mixed gas is continuously and accurately input into the deodorization tank 1 at a stable flow rate to meet the strict requirements of the deodorization process of the oral liquid extract containing pilose antler of Cervus elaphus for the input amount of the mixed gas; on the other hand, when the first control valve 19 is in the closed state, it can effectively seal the deodorization tank 1 to prevent the leakage of the mixed gas.

[0128] The carbon dioxide gas source inlet 16 is connected to a carbon dioxide gas source, and the nitrogen gas source inlet 17 is connected to a nitrogen gas source.

[0129] The carbon dioxide gas source inlet 16 is provided with a second control valve 20, and the nitrogen gas source inlet 17 is provided with a third control valve 21; the second control valve 20 and the third control valve 21 are respectively used to control the on-off, flow rate and intake pressure of carbon dioxide and nitrogen, so as to accurately adjust the ratio of carbon dioxide and nitrogen in the gas mixing tank 2, and meet the specific requirements for the composition of the mixed gas in the deodorization process of the oral liquid extract containing red deer antler. The second control valve 20 and the third control valve 21 are respectively used to control the on-off, flow rate and intake pressure of carbon dioxide or nitrogen, and adjust the ratio of carbon dioxide and nitrogen output to the gas mixing tank 2, and the weight ratio of carbon dioxide and nitrogen is 50%.

[0130] The screw vacuum pump unit 4 is connected to the mixed waste gas exhaust port 8 at the top of the deodorization tank 1 via a pipeline.

[0131] The screw vacuum pump unit 4 is used to ensure that the deodorizing tank 1 is in a micro-vacuum state of -0.05Pa to -0.08Pa during the deodorizing process; on the other hand, it ensures that the mixed gas of carbon dioxide and nitrogen after deodorization is extracted after the deodorizing is completed.

[0132] The cooling tower 5 is connected to the screw vacuum pump unit 4 through a pipeline, and the cooling water tank 6 is connected to the cooling tower 5 through a pipeline. The mixed gas of carbon dioxide and nitrogen after deodorization extracted by the screw vacuum pump unit 4 is emptied to the cooling tower 5 through a pipeline.

[0133] After the mixed exhaust gas enters the cooling tower 5, it is fully in contact with the air entering from the bottom or the side in the packing layer, and the heat is transferred to the air. The mixed exhaust gas is gradually cooled and condensed into water droplets. The condensed water droplets fall to the water collecting tray at the bottom of the cooling tower 5 under the action of gravity, and the condensed water flows back to the cooling water tank 6 through the pipe for storage.

[0134] When using the device described, the following operating principle is adopted:

[0135] The oral liquid extract containing red deer antler is input into a deodorizing tank, a mixed gas of nitrogen and carbon dioxide is introduced from the bottom of the deodorizing tank, and deodorization is performed by stirring, and the mixed gas of nitrogen and carbon dioxide stripped of the fishy smell of the oral liquid extract containing red deer antler is extracted from the top of the deodorizing tank; the deodorizing tank is maintained at a slight vacuum of -0.05Pa to -0.08Pa and a temperature of 40°C to 60°C, and the input and extraction of the mixed gas of nitrogen and carbon dioxide are carried out simultaneously.

[0136] The deodorization method can also be applied to extracts of polygonatum, wolfberry, American ginseng, ganoderma lucidum, and red deer antler, and obtains good results.

[0137] Although the above embodiments have described the present invention in detail, they are only a part of the embodiments of the present invention, rather than all embodiments. People can also obtain other embodiments based on this embodiment without creative efforts, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A deodorant, characterized in that: The deodorant is composed of carbon dioxide gas and nitrogen gas, wherein the carbon dioxide gas accounts for 30% to 50% by weight of the deodorant, and the nitrogen gas accounts for 50% to 70% by weight of the deodorant.

2. A method for deodorizing an oral liquid extract containing red deer antler, characterized in that: The following steps are involved: The deodorant according to claim 1 is introduced from the bottom of the deodorizing device and extracted from the top of the deodorizing device to deodorize the oral liquid extract containing red deer antler; during deodorization, the temperature in the deodorizing device is 40°C to 60°C and the vacuum degree is -0.05Pa to -0.08Pa.

3. The deodorization method according to claim 2, characterized in that: During deodorization, the input rate of the deodorant is 0.5-0.8 liters / minute; the oral liquid extract containing red deer antler includes ganoderma lucidum, American ginseng, wolfberry, polygonatum and red deer antler.

4. The deodorization method according to claim 3, characterized in that: The mass ratio of the ganoderma lucidum, American ginseng, wolfberry, polygonatum and elk antler is 1:1:1.2:(1.5-1.6):(0.17-0.34).

5. The deodorization method according to claim 2, characterized in that: Before deodorizing the oral liquid extract containing red deer antler, the temperature of the extract is controlled at 40-60° C. in the deodorizing device and stabilized for 20-40 minutes.

6. The deodorization method according to claim 2, characterized in that: The introduction and extraction of the deodorant are carried out simultaneously.

7. A deodorizing device based on the deodorizing method according to any one of claims 2 to 6, characterized in that: It comprises a deodorizing tank (1), a gas mixing tank (2), a continuous temperature control jacket (3), a screw vacuum pump unit (4), a cooling tower (5) and a cooling water tank (6); The top of the deodorizing tank (1) is provided with an extract inlet (7) and a mixed waste gas exhaust port (8), and the bottom of the deodorizing tank (1) is provided with a mixed gas inlet (9) and an extract outlet (10); a servo motor (11) is installed at the center of the outer side of the top of the deodorizing tank (1), and a stirring shaft (12) is fixedly installed on the servo motor (11), and the stirring shaft (12) is arranged inside the deodorizing tank (1), and the outer wall of the stirring shaft (12) is provided with 4 to 6 stirring blades (13); The continuous temperature control jacket (3) is coated on the outer wall of the deodorizing tank (1); The gas mixing tank (2) is provided with a carbon dioxide gas source inlet (16), a nitrogen gas source inlet (17) and a mixed gas outlet (18); the mixed gas outlet (18) is connected to the mixed gas inlet (9) via a connecting pipe; a first control valve (19) is provided at the connection between the connecting pipe and the mixed gas inlet 9 for controlling the flow of the mixed gas and sealing the deodorization tank (1); The screw vacuum pump unit (4) is connected to the mixed exhaust gas exhaust port (8), the cooling tower 5 is connected to the screw vacuum pump unit 4 via a pipeline, and the cooling water tank 6 is connected to the cooling tower 5 via a pipeline.

8. Use of the deodorizing agent according to claim 1, the deodorizing method according to any one of claims 2 to 6, or the deodorizing device according to claim 7 in removing the fishy smell of animal-derived extracts.

9. The use according to claim 8, characterized in that: The animal-derived extract is an extract containing red deer antler.

10. The use according to claim 8, characterized in that: The extract containing red deer antler is the oral liquid extract containing red deer antler as claimed in claim 5.

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