A method for preparing a skincare composition, its delivery system, and its application.

Abstract

This invention relates to a method for preparing a skincare composition, its delivery system, and its applications. The method involves preparing a nanoemulsion carrier comprising phospholipid-amine bond-polyethylene glycol, chitosan, etc.; mixing phytoestrogens powder, moisturizers, whitening ingredients, etc., to obtain an active ingredient mixture; integrating the two and adding a penetration enhancer to form a skincare composition. This composition exhibits excellent active ingredient permeability and good stability in in vitro transdermal absorption tests; skin moisture content remains stable above 60% after 4 hours; significant improvement in skin brightness is observed in whitening tests; and in anti-aging performance tests, facial wrinkles are reduced by approximately 40% after 3 months of use, with a good user experience and no adverse reactions, demonstrating broad market application prospects.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a method for preparing a skin care composition, its delivery system and application, aiming to improve moisturizing, whitening and anti-wrinkle effects, while solving the problems of active ingredient stability and skin permeability. Background Technology

[0002] As people place increasing importance on skincare, their demands for the quality of cosmetics and skincare products are also rising. Currently, the quality of anti-aging cosmetics on the market varies greatly. Most anti-aging cosmetics typically contain polyphenols, vitamins, or peptides as their active ingredients. These active ingredients are sensitive to environmental factors such as light, heat, and pH levels. Adding them directly to product formulations can easily lead to degradation and inactivation due to environmental influences. Furthermore, the stratum corneum of the skin has a strong barrier function, making it difficult for many active molecules, such as active peptides, to penetrate and effectively reach their target areas, thus significantly weakening the skincare effect and resulting in insignificant anti-aging results. Moreover, since skin aging is a complex physiological process involving multiple mechanisms, it requires the synergistic effect of various active substances with different mechanisms of action to fully achieve anti-aging efficacy. However, most anti-aging skincare products on the market currently only address skin aging by focusing on anti-oxidation, lacking a diversified anti-aging strategy, ultimately leading to unsatisfactory anti-aging effects.

[0003] Phytoestrogens, as natural active ingredients, have attracted much attention due to their various beneficial effects on the skin, such as whitening, moisturizing, and anti-aging. For example, estrogen mimics (such as soy isoflavones and red clover extract) can activate skin estrogen receptors, promote collagen synthesis, improve barrier function, and inhibit melanin production. However, in practical applications, phytoestrogens face several unresolved issues: firstly, their active ingredients are relatively unstable and easily lose their activity due to environmental factors; secondly, phytoestrogens have low penetration efficiency in the skin barrier, making it difficult to reach deep into the skin to exert their effects. These factors significantly limit the widespread application of phytoestrogens in cosmetics and skincare products.

[0004] Existing technologies have proposed several solutions to the above problems: (1) Carrier encapsulation technology: microencapsulation (such as cyclodextrin encapsulation), liposomes or nanoemulsion systems are used to reduce the degradation effect of environmental factors on phytoestrogens through physical isolation. For example, the encapsulation rate of soybean isoflavones is increased to 85% by using lecithin-cholesterol composite carriers, and the room temperature storage stability is extended to 12 months. However, the particle size of such carriers is mostly in the range of 100-500 nm. Although it can improve the retention in the epidermal layer, it is difficult to achieve delivery to the dermal layer, and high concentrations of surfactants may cause skin irritation. (2) Chemical modification strategy: molecular stability is enhanced by glycosylation, esterification or polymer grafting (such as polyethylene glycolation), but chemical modification may cause skin allergies or discomfort. (3) Transdermal permeation enhancement technology: the combined use of alcohols (such as ethanol), fatty acids and other permeation enhancers or physical permeation enhancers (microneedles, iontophoresis) promotes the penetration of phytoestrogens into the deep layers of the skin. As reported in the literature, the transdermal absorption of puerarin can be significantly increased by using an ethanol-menthol co-solvent system, but long-term use can damage the skin barrier and trigger sensitive reactions.

[0005] Despite the progress made in existing technologies, the following key issues still need to be addressed: First, it is difficult to achieve a balance between enhanced stability and improved transdermal efficiency. Most carrier systems reduce transdermal efficiency while improving stability due to excessively large particle size or unsuitable surface charge. Second, there is a significant contradiction between the biocompatibility of carrier materials and the controllability of the release of active ingredients. For example, although chitosan-based carriers have pH-responsive release characteristics, their cationic properties easily interact with lipids in the stratum corneum, causing a feeling of tightness in the skin and triggering skin discomfort.

[0006] Therefore, developing a skincare composition that possesses both highly effective stabilizing properties and deep skin penetration, while also exhibiting good skin adaptability, without disrupting the skin barrier function, has become the key to breaking through the application of phytoestrogens in skincare products. Summary of the Invention

[0007] The purpose of this invention is to overcome the defects of the prior art by providing a method for preparing a skin care composition based on phytoestrogens, its delivery system and application, which effectively delivers phytoestrogens to the deep layers of the skin in a specific manner and exerts multiple effects. This system effectively solves the problems of poor stability and low penetration efficiency of phytoestrogens in the skin barrier, and significantly improves the efficacy in whitening skin, moisturizing skin, improving complexion and anti-aging.

[0008] This invention relates to a method for preparing a skincare composition, comprising the following steps:

[0009] (1) Preparation of nanoemulsion carrier: Phospholipid-hydrazone bond-polyethylene glycol, chitosan, ceramide, emulsifier and appropriate amount of water are mixed and subjected to high-speed shearing and homogenization to form nanoemulsion carrier;

[0010] (2) Mixing of active ingredients: Disperse the phytoestrogens powder, moisturizer and whitening ingredients in water respectively, mix them evenly to obtain a mixture of active ingredients;

[0011] (3) Integration system: Add the mixture obtained in step (2) to the nanoemulsion carrier prepared in step (1), stir evenly, add a penetration enhancer, and continue stirring until completely dispersed to form a uniform skin care composition.

[0012] Preferably, the high-speed shearing is 7000-10000 r / min for 1-15 min; the homogenization treatment is 10-100 MPa homogenization treatment 1-10 times.

[0013] Preferably, the phytoestrogens powder includes any one of soy isoflavones, resveratrol, and puerarin, and more preferably, it is a compound of soy isoflavones, resveratrol, and puerarin in a mass ratio of 5-15:3-10:2-8.

[0014] Preferably, the chitosan has a number-average molecular weight of 1000-5000 Da and a degree of deacetylation >90%.

[0015] Preferably, the emulsifier is at least one selected from polyoxyethylene castor oil emulsifiers, polyoxyethylene hydrogenated castor oil emulsifiers, polyglycerol emulsifiers, and glucoside emulsifiers.

[0016] Preferably, the moisturizer includes at least one of hyaluronic acid, glycerin, and butylene glycol.

[0017] Preferably, the whitening ingredient includes at least one of niacinamide, sialic acid, vitamin C, carnosine, and ellagic acid.

[0018] Preferably, the penetration enhancer is a natural penetration enhancer, which is at least one of tea tree oil and lauryl alcohol derivatives. The lauryl alcohol derivative is at least one of lauryl ketone, menthol laurate, and polyethylene glycol-modified lauric acid.

[0019] Preferably, the skin care composition further comprises one or more additives selected from the group consisting of: emollients, thickeners, plant extracts, pH adjusters, fragrances, and combinations thereof.

[0020] Preferably, the emollient is at least one of squalane, jojoba oil, caprylic / capric triglyceride, polydimethylsiloxane, polydimethylsiloxane alcohol, and hydrogenated polyisobutylene.

[0021] Preferably, the thickener is at least one selected from xanthan gum, carbomer, sodium polyacrylate, and sodium carboxymethyl cellulose.

[0022] Preferably, the plant extract is at least one of licorice extract, aloe vera extract, Dendrobium officinale extract, and Centella asiatica extract.

[0023] Preferably, the pH adjuster is at least one of disodium ethylenediaminetetraacetate, triethanolamine, and sodium citrate.

[0024] Preferably, the fragrance is selected from at least one of vanillin, menthol, rose essential oil, jasmine essential oil, carnation essential oil, gardenia essential oil, and violet essential oil.

[0025] The nanoemulsion carriers of this invention are skin delivery systems containing ceramides and phospholipids with structures similar to skin lipids. On one hand, the multi-effect skin delivery system can promote or improve the skin's absorption of active ingredients such as phytoestrogens. On the other hand, the multi-effect skin delivery system containing nanoemulsion carriers can enhance skin affinity and moisturizing power by forming a layered structure similar to the stratum corneum, thereby improving the skin barrier function.

[0026] Preferably, the particle size of the nanoemulsion carrier in step (1) is between 50-300 nm, more preferably 100-300 nm, and particularly preferably 150-200 nm. A particle size within this range can improve the stability of active ingredients such as phytoestrogens and promote their skin penetration. When the particle size exceeds the above range, the stability of the nanoparticle delivery carrier decreases. When the particle size is below the above range, particle aggregation is likely to occur, which is not conducive to promoting the penetration of active ingredients, and the absorption of active ingredients such as phytoestrogens by the skin decreases.

[0027] Preferably, the content of phospholipid-hydrazone-polyethylene glycol is 0.01-3 wt% relative to the total weight of the skin care composition, and more preferably, the content of phospholipid-hydrazone-polyethylene glycol is 0.5-1.5 wt%.

[0028] Preferably, the ceramide content is 0.05-1.5 wt% relative to the total weight of the skin care composition, and more preferably, the ceramide content is 0.1-0.5 wt%.

[0029] Preferably, the content of the phytoestrogens powder is 1-10 wt% relative to the total weight of the skin care composition.

[0030] Preferably, the chitosan content is 0.01-0.5 wt% relative to the total weight of the skin care composition.

[0031] Preferably, the emulsifier content is 0.5-5.0 wt% relative to the total weight of the skin care composition.

[0032] Preferably, the moisturizer content is 1-5 wt% relative to the total weight of the skin care composition.

[0033] Preferably, the content of the whitening ingredient is 0.5-2 wt% relative to the total weight of the skin care composition.

[0034] Preferably, the penetration enhancer content is 0.1-5 wt% relative to the total weight of the skin care composition.

[0035] The phospholipid-hydrazone bond-polyethylene glycol (PEG) system used in this invention combines the biocompatibility of phospholipids, the pH sensitivity of hydrazone bonds, and the stability and hydrophilicity of PEG, effectively improving the permeability and stability of active ingredients. This carrier system not only protects active ingredients from degradation but also enhances their efficacy in the skin through precise release and sustained-release mechanisms. Phospholipids are a major component of cell membranes and possess excellent biocompatibility and affinity. Phospholipids can form stable bilayer structures that encapsulate active ingredients, creating a cell membrane-like structure that protects them from external environmental influences and enhances their stability during storage and use. Hydrazone bonds are pH-sensitive chemical bonds, stable in neutral pH environments but hydrolyzing and breaking under acidic conditions (such as the skin surface or hair follicle microenvironment), releasing the encapsulated active ingredients and increasing local concentration and penetration efficiency. This characteristic allows for precise release of active ingredients at the desired site, improving their permeability and utilization in the skin. The hydrophilicity of PEG can reduce the interfacial tension between the skin surface and the active ingredients, making it easier for the active ingredients to penetrate into the deeper layers of the skin.

[0036] Furthermore, this invention combines chitosan and ceramides as carriers for phytoestrogens, synergistically enhancing the permeability and stability of these active ingredients. Ceramides, similar in structure to the skin's natural lipids, repair the stratum corneum barrier and form lipid channels, promoting the penetration of lipid-soluble components. In addition, ceramides, along with phospholipid-hydrazone bonds and polyethylene glycol, construct a lipid bilayer membrane, isolating easily oxidized active substances, synergistically providing antioxidant protection, and stabilizing the emulsion system, significantly improving the chemical stability of the active ingredients. Chitosan forms a semi-permeable membrane on the skin surface, prolonging the residence time of active ingredients, enhancing ingredient penetration, and further improving skincare effects such as moisturizing. Therefore, when these three are used together, a "phospholipid-lipid-polysaccharide complex carrier" is formed. Combining the physical barrier of chitosan with the chemical protection of ceramides, it achieves improved transdermal absorption efficiency and highly effective protection against photosensitive ingredients. Furthermore, by utilizing nanostructured and biomimetic liposome technologies to optimize the delivery system, it ultimately enhances skincare efficacy by increasing penetration depth, prolonging the duration of action, and maintaining activity stability.

[0037] Furthermore, the natural penetration enhancers used in this invention, tea tree oil (containing terpenoids) and lauryl alcohol derivatives (such as lauryl azone), are derived from plant extracts and have a similar lipid structure to the skin. They can reduce damage to the skin barrier, lower the risk of allergies or irritation, and also have multiple functions such as antibacterial, antioxidant, and repair properties, further improving the skin's moisturizing and whitening properties.

[0038] The present invention also relates to a skin care composition based on phytoestrogens, which is prepared using the preparation method described in the present invention.

[0039] This invention provides the application of a phytoestrogen-based skincare composition in skincare products, wherein the composition is added to the skincare product, which includes any one of creams, lotions, lotions, masks, or lotions.

[0040] The present invention also relates to a delivery system for a skin care composition based on phytoestrogens, wherein the composition is prepared using the preparation method described in the present invention.

[0041] The advantages or beneficial effects of the above technical solutions include at least the following:

[0042] This invention's delivery system innovatively employs phospholipid-hydrazone bond-polyethylene glycol, chitosan, and ceramide as nanoemulsion carriers. It contains active ingredients and penetration enhancers, including phytoestrogens, moisturizers, and whitening agents, achieving highly efficient and stable delivery of phytoestrogens. Simultaneously, it exhibits synergistic effects in moisturizing, whitening, and anti-wrinkle properties. The skincare composition contained in this delivery system has a simple preparation process, high stability, a lightweight and easily absorbed texture, and is non-irritating, suitable for all skin types, demonstrating significant market competitiveness and application prospects. Detailed Implementation

[0043] To more clearly illustrate the purpose, technical solution, and advantages of this invention, the technical solution of this invention will be described in detail below through specific embodiments. It should be noted that these embodiments are only for illustrating this invention and not for limiting its scope of protection; the actual scope of protection of this invention should be determined by the claims.

[0044] Unless otherwise specified, the materials and reagents used in the following examples and comparative examples are commercially available. Unless otherwise specified, the amount of each component in the following examples is 1 g per part by weight.

[0045] Experimental materials:

[0046] Phospholipid-hydrazone bond-polyethylene glycol 1#, DSPE-HYD-PEG, Xi'an Qiyue Biotechnology, Item No. Q-0094638.

[0047] Phospholipid-hydrazone bond-polyethylene glycol 2#, DSPE-HYD-PEG2000, Guangzhou Weihua Biotechnology Co., Ltd., product number WH00164004.

[0048] Resveratrol was purchased from Shaanxi Angxu Biotechnology Co., Ltd., and its purity was 98%.

[0049] Puerarin was purchased from Chengdu Pusi Biotechnology Co., Ltd., with the product number PS0180-5000 and a purity of 98%.

[0050] Soy isoflavones were purchased from Hubei Jianchu Biomedical Co., Ltd. The purity of soy isoflavones was 98%, and the product number was 964158. Example

[0051] A skincare composition including phytoestrogens, the preparation method of which includes the following steps:

[0052] (1) Preparation of nanoemulsion carrier: According to the composition and content of nanoemulsion carrier in Table 1, the nanoemulsion carrier was sheared at 8000 r / min for 6 min by a high-speed shearing machine, followed by homogenization at 50 MPa 5 times to form nanoemulsion carrier;

[0053] (2) Mixing of active ingredients: According to the composition and content of active ingredients in Table 1, stir and mix evenly at 70°C to obtain a mixture;

[0054] (3) Integration system: Add the mixture obtained in step (2) to the nanoemulsion carrier prepared in step (1), stir at 200 rpm and 70°C for 1 h, add the penetration enhancer, and continue stirring for 1 h until completely dispersed to form a uniform skin care composition.

[0055] (4) Mix the emulsion with the skin care composition of step (3) to obtain the emulsion.

[0056] Table 1: The mass fractions (g) of each component in Examples 1-8 are as follows:

[0057]

[0058] Table 2: The mass fractions (g) of each component in Comparative Examples 1-5 are as follows:

[0059] .

[0060] Comparative Example 6

[0061] The raw material composition and mass fraction are the same as in Example 2. The difference from Example 2 is that step (1) is not subjected to high-speed shearing and homogenization treatment. The components are stirred and mixed evenly to prepare an emulsion. Other conditions are the same as in Example 2.

[0062] Performance evaluation:

[0063] 1. Transdermal permeation test of the sample

[0064] Pigskin was used to simulate human epidermal skin. The pigskin was cut into 5cm x 5cm pieces and then soaked in physiological saline for 30 minutes to serve as a transdermal barrier. A Franz diffusion cell was used as the static diffusion cell. The tested cosmetic was used as the transdermal release solution, and 30% physiological saline was used as the transdermal absorption solution. The transdermal absorption test was conducted at a constant temperature of 36℃ and a constant flow rate of 600 rpm. After 24 hours, 5 mL of the permeate was collected from each sampling point using a clean syringe, and then 5 mL of 30% physiological saline was added using a clean syringe. The resveratrol content in the sample was determined by high-performance liquid chromatography (HPLC).

[0065] Resveratrol permeability = (amount of resveratrol in the receiving cell / amount of resveratrol in the emulsion) × 100%.

[0066] Table 3: Results of in vitro transdermal absorption test

[0067] .

[0068] The test results in Table 3 show that the skincare lotion prepared in Example 2 of this invention exhibits a significantly higher in vitro transdermal permeability than the comparative example. This indicates that the phospholipid-hydrazone bond-polyethylene glycol, chitosan, and ceramide in this invention form a nanoemulsion carrier, which is beneficial for loading active ingredients such as phytoestrogens. High-speed shearing and homogenization processes facilitate the dispersion of the nanoemulsion carrier, effectively enhancing the skin penetration performance of phytoestrogens and allowing them to penetrate deep into the skin to fully exert their efficacy.

[0069] 2. Stability of nanoemulsion carriers

[0070] To verify the effect of nanoemulsion carriers on the stability of skincare emulsions, 50 ml of each of the example and comparative emulsions were placed in transparent glass bottles and stored at 50°C and 550 Lux. The appearance of the emulsions was inspected weekly. The color, transparency, presence of layering, flocculation, and other phenomena were observed.

[0071] The test results are as follows: After 16 weeks of continuous observation, the skin care lotions of Examples 1-8 and the lotion of Comparative Example 5 showed no separation, flocculation, or color change; the lotion of Comparative Example 1 began to show slight flocculation at week 12 and severe separation after week 16; Comparative Examples 2-4 and 6 also showed slight flocculation and decreased transparency after week 16. This demonstrates that the skin care combination of the present invention has better stability.

[0072] 3. Long-lasting moisturizing performance test

[0073] Healthy female volunteers aged 35–55 years were selected and used the skincare lotions provided in the examples and comparative examples, with 5 participants in each group. Facial skin moisture content was quantitatively measured using a Corneometer CM825 at 0 h, 1 h, and 4 h. By comparing changes in moisture before and after use, the product's long-lasting moisturizing ability was evaluated to characterize whether phytoestrogens could penetrate the skin barrier and reach the deeper layers of the skin. Moisturizing rate and hydration rate are average values ​​for each group of subjects. Hydration rate after 1 h / % = (1 h moisture content / 0 h moisture content) * 100; Hydration rate after 4 h / % = (4 h moisture content / 0 h moisture content) * 100.

[0074] Table 4: Moisturizing Performance Test

[0075]

[0076] According to the test data in Table 4, the skin hydration rates of the skin lotions in the examples and the comparative examples were similar after 1 hour of use. However, after 4 hours of use, the lotion in the examples maintained a stable skin hydration level of over 60%, while the lotion in the comparative examples resulted in a significant decrease in skin hydration. This may be because the penetration enhancer used in the examples facilitates the penetration of phytoestrogens into the deeper layers of the skin, continuously releasing active ingredients on the skin surface, thereby achieving a long-lasting skincare effect.

[0077] 4. Whitening Test

[0078] Experimental Methods: Healthy female volunteers aged 35-55 were selected, and each group used the skincare products from the example and comparative examples for 30 consecutive days, twice a day, morning and evening. Each group consisted of one person. A colorimeter was used to measure and calculate the average change in skin brightness (ΔL) before and after use. The results are shown in Table 5.

[0079] Table 5: Whitening Test Results

[0080]

[0081] As shown in Table 5, the skin care lotions prepared in Examples 1-8 exhibited significant advantages in terms of skin brightness change (ΔL), demonstrating good whitening effects and promoting the penetration of phytoestrogens into the basal layer of the skin, thereby achieving a whitening effect. In contrast, the phytoestrogens in Comparative Examples 1-6 penetrated less into the deeper layers of the skin, providing a less lasting skin care effect on the skin surface, resulting in decreased whitening performance.

[0082] 5. Anti-aging test

[0083] This study recruited volunteers aged 30-50 as subjects, who used the lotions from the embodiments and comparative examples of this invention. Each group consisted of 5 participants. Before the test, the faces were cleansed, and facial wrinkles were initially assessed using the VISIA facial image analyzer. Afterwards, each group of subjects used the assigned product once nightly. After 1, 2, and 3 months of continuous product use, facial wrinkles were again assessed using the VISIA facial image analyzer, and the wrinkle reduction effect was analyzed to evaluate the wrinkle removal effect of each experimental group's product and calculate the wrinkle reduction rate. The wrinkle reduction rate results of the anti-aging performance test for each experimental group's product are shown in Table 6 below.

[0084] Table 6 Anti-aging performance test

[0085]

[0086] According to the anti-aging performance test results in Table 6, the emulsion prepared by this invention performs excellently in anti-aging and wrinkle reduction. After three consecutive months of use, facial wrinkles were reduced by 40%, which is significantly better than comparative examples 1-6. This shows that the nanoemulsion carrier formed by phospholipid-hydrazone bond-polyethylene glycol, chitosan, and ceramide is conducive to the loading of active ingredients such as phytoestrogens, and can promote the entry of phytoestrogens into the basal layer of the skin, achieving a more long-lasting skin repair effect and significantly improving the wrinkle reduction rate.

[0087] 6. User Experience Evaluation

[0088] To evaluate the product's user experience, a questionnaire was administered to healthy female volunteers aged 35-55. Each group scored 5 points. Volunteers used both the sample and comparative versions of the lotion for 30 consecutive days, twice daily (morning and evening). Volunteers recorded any discomfort such as itching, burning, or persistent skin redness.

[0089] According to the test results, no discomfort or allergic reactions, such as itching, burning or persistent skin redness, were observed in the volunteers of both the example and comparative examples during use. They also generally reported that the product was soft and comfortable, had a long-lasting moisturizing effect, and could effectively brighten skin tone and remove blemishes, resulting in an excellent overall user experience.

[0090] The above embodiments are merely examples to illustrate the present invention and are not intended to limit the possible implementations of the invention. Based on the disclosure of this invention, those skilled in the art can make various modifications and adjustments. It is neither possible nor necessary to list all possible implementations. Any modifications, equivalent substitutions, or improvements made within the basic principles and scope of this invention should be considered to fall within the protection scope of this invention.

Claims

1. A method of preparing a skin care composition, characterized by, The method comprises the following steps: (1) Preparation of nanoemulsion carrier: mix phospholipid-hydrazone-polyethylene glycol, chitosan, ceramide, emulsifier and appropriate amount of water, and form nanoemulsion carrier through high-speed shearing and homogenization treatment; (2) Mixing of active ingredients: disperse phytoestrogen powder, humectant and whitening ingredients in water respectively, mix uniformly, and prepare the mixture of active ingredients; (3) Integration of system: add the mixture obtained in step (2) into the nanoemulsion carrier prepared in step (1), stir uniformly, add penetration enhancer, continue to stir until completely dispersed, and form uniform skin care composition; The high-speed shearing is 7000-10000r / min shearing for 1-15min; the homogenization treatment is 10-100Mpa homogenization treatment for 1-10 times; The phytoestrogen powder comprises at least one of soy isoflavone, resveratrol and puerarin; The content of the phospholipid-hydrazone-polyethylene glycol is 0.01-3wt% relative to the total weight of the skin care composition, the content of the ceramide is 0.05-1.5wt%, the content of the phytoestrogen powder is 1-10wt%, and the content of the chitosan is 0.01-0.5wt%; The emulsifier is at least one of polyoxyethylene castor oil emulsifier, polyoxyethylene hydrogenated castor oil emulsifier, polyglycerol emulsifier and glucoside emulsifier; The penetration enhancer is a natural penetration enhancer.

2. The method of making a skin care composition according to claim 1, wherein, The phytoestrogen powder is a mixture of soy isoflavone, resveratrol and puerarin in a mass ratio of 5-15:3-10:2-8.

3. The method of making a skin care composition according to claim 1, wherein, The number average molecular weight of the chitosan is 1000-5000Da, and the degree of deacetylation is greater than 90%.

4. Process for the preparation of a skin care composition according to any of claims 1 to 3, characterized in that The humectant comprises at least one of hyaluronic acid, glycerol and butanediol; the whitening ingredient comprises at least one of niacinamide, bird's nest acid, vitamin C, lycium peptide and ellagic acid; the natural penetration enhancer is at least one of tea tree oil and lauryl alcohol derivative; the lauryl alcohol derivative is at least one of lauryl azone, lauryl menthol laurate and polyoxylated lauric acid.

5. A process for the preparation of a skin care composition according to any of claims 1 to 3, wherein The skin care composition further comprises one or more additives selected from the group consisting of emollient, thickening agent, plant extract, pH regulator, flavoring agent and combination thereof.

6. The method of making a skin care composition according to claim 5, wherein the skin care composition is prepared by mixing the ingredients in the order listed in Table 1. The emollient is at least one of squalane, jojoba oil, caprylic / capric acid triglyceride, dimethicone, dimethiconol and hydrogenated polyisobutylene; the thickening agent is at least one of xanthan gum, carbomer, sodium polyacrylate and sodium carboxymethyl cellulose; the plant extract is at least one of licorice extract, aloe extract, dendrobium officinale extract and gotu kola extract; the pH regulator is at least one of disodium ethylenediaminetetraacetate, triethanolamine and sodium citrate; and the flavoring agent is at least one of vanillin, menthol, rose essential oil, jasmine essential oil, carnation essential oil, gardenia essential oil and violet essential oil.

7. The method of making the skin care composition of claim 1, wherein, The emulsifier is present in an amount of 0.5 to 5.0 wt%, the humectant is present in an amount of 1 to 5 wt%, the whitening ingredient is present in an amount of 0.5 to 2 wt%, and the penetration enhancer is present in an amount of 0.1 to 5 wt%, relative to the total weight of the skin care composition.

8. A skin care composition characterized in that, The skin care composition is prepared by the method of any one of claims 1 to 7.

9. Use of a skin care composition according to claim 8 for the manufacture of a skin care product, characterized in that The skin care product is any one of a cream, a lotion, a serum, a toner, a pack, or a wash.

10. A delivery system for a skin care composition characterized in that, The delivery system comprises the skin care composition of claim 8 or the skin care composition prepared by the method of any one of claims 1 to 7.

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