Chewable soft capsule

Abstract

Provided is a chewy soft capsule which has a good texture, suppresses coagulation between capsules, adhesion to a container, and discoloration of the soft capsule, and has excellent storage stability. Disclosed is a chewable soft capsule which is provided with a capsule coating film and a capsule content. Wherein the capsule coating contains the following components (A) and (B): (A) 1-35% by mass of gelatin, and (B) 3-25% by mass of a dehydrated galactose / sulfated dehydrated galactose copolymer.

Description

Technical Field

[0001] The present invention relates to a soft capsule that can be chewed in the oral cavity. Background Art

[0002] In recent years, as the uses of soft capsules have been continuously expanded, attempts have been made to develop soft capsules having the same taste and texture as gummy candies. By adding a large amount of plasticizers, starches, sugars, etc., research has been conducted on the capsule film so that the capsule film can be chewed.

[0003] For example, Patent Document 1 discloses: a soft capsule preparation having a film composed of a gelling agent containing gelatin and mucopolysaccharides, and an oral soft composition containing a polyol, a water-soluble polysaccharide, a cellulose, and starch, which has excellent taste and texture, and is less likely to cause coagulation between the compositions and less likely to adhere to a container. In addition, Patent Document 2 discloses: a chewable soft capsule prepared by adding a specific plasticizer several times the usual amount to a gelatin skin and adding a water-insoluble cellulose has a good bite texture and less adhesiveness.

[0004] However, the problems of coagulation between capsules and adhesion of capsules to a container have not been sufficiently improved, and there are still doubts about problems such as easy discoloration of the capsule film.

[0005] On the other hand, κ-2 carrageenan is known as a mucopolysaccharide contained in seaweeds belonging to Gigartinaceae algae, and is a copolymer of anhydrogalactose, which is a part of the κ-carrageenan constituent unit, and sulfated anhydrogalactose, which is a part of the ι-carrageenan constituent unit. It has been reported that this κ-2 carrageenan can be used as a substitute for gelatin and can be a gelling agent for manufacturing soft capsules (Patent Document 3), but there has never been a report of using gelatin together with a capsule film, so it is not clear what kind of properties the soft capsules will have.

[0006] Prior Art Documents

[0007] Patent Documents

[0008] Patent Document 1: Japanese Unexamined Patent Application Publication No. 2021-175740

[0009] Patent Document 2: Japanese Patent No. 3261331

[0010] Patent Document 3: Japanese Patent No. 4558721 Summary of the Invention

[0011] The present invention relates to providing a chewable soft capsule having a good taste, capable of improving coagulation between capsules, adhesion to a container, and discoloration of soft capsules, and having excellent storage stability.

[0012] The inventors of the present invention conducted various in-depth studies to solve this problem, and as a result, it was found that: a soft capsule formed with a capsule film containing a specific amount of gelatin and a specific amount of galactose anhydride / sulfated galactose anhydride copolymer has the same texture as gummy candy when chewed, and can improve the condensation between capsules, adhesion to the container, and color change during storage.

[0013] That is, the present invention is as follows 1) to 6).

[0014] 1) A chewable soft capsule, which is a chewable soft capsule having a capsule film and a capsule content; wherein the capsule film contains the following components (A) and (B):

[0015] (A) Gelatin 1 to 35% by mass,

[0016] (B) Galactose anhydride / sulfated galactose anhydride copolymer 3 to 25% by mass.

[0017] 2) The chewable soft capsule according to 1), wherein (B) the galactose anhydride / sulfated galactose anhydride copolymer is a 3,6-anhydrogalactose / 3,6-anhydrogalactose-2-sulfate copolymer.

[0018] 3) The chewable soft capsule according to 2), wherein the molar ratio of the content of 3,6-anhydrogalactose to 3,6-anhydrogalactose-2-sulfate (3,6-AG-2-S / 3,6-AG) is 25 to 50%.

[0019] 4) The chewable soft capsule according to any one of 1) to 3), wherein the mass ratio of the content of (A) gelatin to (B) the galactose anhydride / sulfated galactose anhydride copolymer [(A):(B)] is 1:25 to 13:1.

[0020] 5) The chewable soft capsule according to any one of 1) to 3), wherein the capsule film contains a plasticizer.

[0021] 6) The chewable soft capsule according to any one of 1) to 3), wherein the chewable soft capsule is a rotary die soft capsule preparation.

[0022] According to the present invention, a soft capsule with a good texture like gummy candy and chewable can be provided. Moreover, this soft capsule can improve the condensation between capsules, adhesion to the container, and color change of the soft capsule during storage, and has excellent storage stability. Detailed embodiments

[0023] In the present invention, (A) gelatin, which is a constituent of the capsule film, serves as the base of the capsule film and is a collagen modified product obtained by treating raw materials of collagen, which are the outer skins, bones, tendons, etc. of cattle, sheep, pigs, chickens, fish, etc. (which belong to the main protein component), with acid or alkali and then extracting with warm water. Regarding the source of collagen and the treatment method of the gelatin used in the present invention, there are no particular limitations.

[0024] In addition, the present invention can also use hydrolyzates or oxidative degradation products of gelatin, modified gelatins such as succinylated gelatin and phthalic acid esterified gelatin, and any type of gelatin can be applied.

[0025] From the viewpoints of the moldability and chewability of the capsule, the content of (A) gelatin in the capsule film is 1% by mass or more, preferably 3% by mass or more, more preferably 6% by mass or more in the total amount of the capsule film composition. On the other hand, the gelatin content is 35% by mass or less, preferably 25% by mass or less, more preferably 16% by mass or less. In addition, the gelatin content is 1 - 35% by mass, preferably 3 - 25% by mass, more preferably 6 - 16% by mass.

[0026] It should be noted that the capsule film composition refers to the total amount of the components constituting the capsule film solution before capsule molding.

[0027] The (B) galactose anhydride / sulfated galactose anhydride copolymer used in the present invention refers to a copolymer of 3,6 - anhydrogalactose (3,6 - AG) and 3,6 - anhydrogalactose - 2 - sulfate (3,6 - AG - 2 - S), and the molar ratio of 3,6 - anhydrogalactose - 2 - sulfate to 3,6 - anhydrogalactose (3,6 - AG - 2 - S / 3,6 - AG) is 25 - 50%.

[0028] This galactose anhydride / sulfated galactose anhydride copolymer is also called κ - 2 carrageenan (R. Falshaw, H. J. Bixler, K. Johndro, Food Hydrocolloids 15(2001)441 - 452; H. Bixler, K Johndro, R Falshaw, Food Hydrocolloids 15(2001)619 - 630).

[0029] The molecular weight of the galactose anhydride / sulfated galactose anhydride copolymer is usually 100,000 daltons or more, preferably 100,000 - 1,000,000 daltons, more preferably 100,000 - 450,000 daltons, and further preferably 100,000 - 350,000 daltons.

[0030] The anhydrogalactose / sulfated anhydrogalactose copolymer exists in seaweeds classified in, for example, Gigartinaceae algae (Gigartina radula, Gigartina corymbifera, Gigartina skottsbergii, Iridaea cordata, Sarcothalia crispata, Mazzaella laminarioides, etc.), and can be obtained by separating, recovering, and purifying them. Additionally, during the separation and recovery process, through alkali treatment, the 3,6-AG-2-S part is desulfated and converted to 3,6-AG (modification treatment), and the ratio of 3,6-AG can also be appropriately increased.

[0031] The separation and recovery method and the modification treatment method are well-known and are described in the literature such as those written by Falshaw, Bixler, Johndro, etc. For example, the modification treatment is carried out by performing alkali treatment under heating during the recovery from Giartinacean algae.

[0032] In addition, the anhydrogalactose / sulfated anhydrogalactose copolymer is commercially available, such as "SEAGEL CAP101" (manufactured by FMC Corporation).

[0033] From the viewpoints of the formability and chewability of the capsule, the content of (B) anhydrogalactose / sulfated anhydrogalactose copolymer in the capsule film is 3% by mass or more, preferably 6% by mass or more, more preferably 8% by mass or more, in the total amount of the capsule film composition, and the content of anhydrogalactose / sulfated anhydrogalactose copolymer is 25% by mass or less, preferably 20% by mass or less, more preferably 16% by mass or less. Additionally, the content of anhydrogalactose / sulfated anhydrogalactose copolymer is 3 - 25% by mass, preferably 6 - 20% by mass, more preferably 8 - 16% by mass.

[0034] In addition, from the viewpoints of chewability and storage stability, the mass ratio of (A) gelatin to (B) anhydrogalactose / sulfated anhydrogalactose copolymer [(A):(B)] is 1:25 - 13:1, more preferably 1:12 - 6:1, and further preferably 3:5 - 5:3.

[0035] The capsule film of the present invention preferably contains a plasticizer that can improve the taste.

[0036] Examples of plasticizers include glycerols (e.g., glycerol, diglycerol, polyglycerol, etc.), sugar alcohols (e.g., sorbitol, xylitol, erythritol, maltitol, mannitol, cyclitol, etc.), diols (e.g., propylene glycol, dipropylene glycol, 1,3 - butanediol, ethylene glycol, polyethylene glycol, etc.), disaccharides, oligosaccharides, etc.

[0037] In the total amount of the capsule film composition, the content of the plasticizer in the capsule film is 10% by mass or more, more preferably 20% by mass or more, further preferably 30% by mass or more, and preferably 60% by mass or less, more preferably 50% by mass or less, and further preferably 45% by mass or less.

[0038] In addition, various additives such as water - soluble polymers, starches, pigments (natural pigments, synthetic pigments), various sweeteners, preservatives, water - reducing agents, pH adjusters, etc. can also be further incorporated into the capsule film as needed.

[0039] The water - soluble polymer is not particularly limited. For example, water - soluble plant fibers derived from plants and seaweeds can be mentioned. For example, pectin, glucomannan, sodium alginate, pullulan, fucoidan, maltodextrin, isomaltodextrin, gellan gum, locust bean gum, xanthan gum, etc. can be cited.

[0040] Examples of starches include unmodified starches, chemically modified starches, starch decomposition products, etc. Examples of plant sources include wheat, rice, barley, glutinous rice, glutinous barley, buckwheat, soybeans, potatoes, cassava, corn, etc.

[0041] The content of the water - soluble polymer and starch in the capsule film is preferably 6% by mass or less in the total solid content.

[0042] It should be noted that in the present invention, the capsule film contains (A) gelatin and (B) a galactose / de - sulfated galactose copolymer, which function as gelling agents. However, as long as it does not affect the chewability and storage stability of the capsule, other gelling agents are not excluded. Here, examples of other gelling agents include carrageenan, locust bean gum, agar, psyllium seed gum, konjac powder, gellan gum, xanthan gum, etc.

[0043] The chewable soft capsule of the present invention can be a roll-mode soft capsule preparation method in which a capsule film composition is stretched on a pair of left and right rotating drums to form a film sheet, the surface of the film sheet is appropriately heated in segments, and then the film sheet is formed into a specified shape using a rotating roller die while coagulating the film sheet and filling the contents at the same time; it can also be a flat-plate soft capsule preparation method in which a film sheet is placed on one of a pair of flat dies, the contents are then placed thereon, the film sheet is covered, and finally the other die is covered, and then it is press-formed into a specified shape; or it can be a seamless soft capsule preparation method in which a capsule film composition and a content liquid discharged simultaneously from a double-layer nozzle existing on a concentric circle are dropped into a coolant flowing at a certain speed. However, from the viewpoints of a wider range of content liquids that can be manufactured, a higher degree of freedom in selecting shapes and sizes, and productivity, etc., the roll-mode soft capsule preparation method is preferred.

[0044] The roll-mode soft capsule preparation method using a roll die for encapsulation can be carried out by injecting a liquid substance, such as an oily liquid, an aqueous liquid, or a substance formed by dispersing a hardly oil-soluble powder, such as an oily liquid, between the capsule film sheets formed into a sheet shape, and then compression molding from both sides.

[0045] As long as the capsule film composition is stirred and dispersed in water with (A) gelatin, (B) a dehydrated galactose / sulfated dehydrated galactose copolymer, and various additives as needed, and then stirred and dissolved at 70-98°C, it can be degassed under vacuum.

[0046] In the chewable soft capsule of the present invention, the contents of the capsule are not particularly limited. As the contents, for example, components used as pharmaceuticals, quasi-drugs (cosmetics for external use), cosmetics, foods (health foods, foods for specified health use, functional foods, supplements, etc.), seasonings, fragrances, etc., which can generally be filled in capsules, can be cited. The form of the contents can be any of a solution, suspension, paste, powder, granule, etc., and a solution, suspension, or paste is preferred. The substances that can be incorporated into the capsule contents are exemplified below.

[0047] As functional oils, for example, the following can be cited: ω3 polyunsaturated fatty acids such as DHA, EPA, and α-linolenic acid; ω6 polyunsaturated fatty acids such as linoleic acid and γ-linolenic acid; and oleic acid, which belongs to ω9 monounsaturated fatty acids.

[0048] In addition, as other oils and fats, for example, the following can be cited: vegetable oils such as soybean oil, rapeseed oil, safflower oil, rice bran oil, corn oil, sunflower oil, cottonseed oil, olive oil, sesame oil, peanut oil, coix seed oil, wheat germ oil, perilla oil, linseed oil, perilla oil, inca nut oil, walnut oil, kiwifruit seed oil, salvia miltiorrhiza seed oil, celery seed oil, grape seed oil, macadamia nut oil, hazelnut oil, almond oil, pumpkin seed oil, toon oil, tea seed oil, borage oil, palm oil, soft palm oil, hard palm oil, coconut oil, palm kernel oil, cocoa butter, sal tree oil, jatropha curcas oil, algal oil, etc.; animal oils such as fish oil, lard, beef tallow, butter or their interesterified oils, hydrogenated oils, separated oils, and other oil and fat products.

[0049] As other materials used as supplements, for example, the following can be cited: ginkgo biloba extract, phosphatidylserine, GABA, plasmalogen from chicken, blueberry extract or blackcurrant extract containing anthocyanins, marigold pigment containing lutein / zeaxanthin, Haematococcus pluvialis pigment containing astaxanthin, gardenia pigment containing sunflower acid, carotenoids such as α-carotene, β-carotene, lycopene, β-cryptoflavin, etc.; quinones such as vitamin K, coenzyme Q10, PQQ, etc.; polyphenols such as flavonol, isoflavone, tannin, catechin, quercetin, anthocyanin, flavangenol extracted from pine bark, flavonoids, etc.; vitamins such as propolis, xylitol, vitamin B1, B2, niacin, pantothenic acid, vitamin B6, vitamin B12, vitamin C, vitamin D3, vitamin E, etc.; minerals such as calcium, phosphorus, sodium, potassium, magnesium, zinc, selenium, chromium, molybdenum, iron, and copper; lactic acid bacteria such as Lactobacillus casei strain Shirota, Lactobacillus gasseri, Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus rhamnosus GG, etc.; bifidobacteria such as Bifidobacterium longum BB-536, Bifidobacterium breve B-3, etc.

[0050] As pharmaceuticals, for example, the following can be cited: Meclizine hydrochloride, scopolamine hydrobromide hydrate, scopolia extract, berberine tannate, sodium fluoride, etc.

[0051] The chewable soft capsules thus obtained have excellent storage stability and can be packaged, stored, and distributed in various packaging forms such as bottled packaging, PTP packaging, and bagged packaging.

[0052] Examples

[0053] Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.

[0054] Examples 1 to 6, Comparative Examples 1 to 9

[0055] 1. Raw materials

[0056] 1) Galactose dehydrate / sulfated galactose dehydrate copolymer: SEAGEL CAP101 (manufactured by FMC Corporation)

[0057] 2) Gelatin (from pigs): BCN200S (manufactured by Nitta Gelatin Inc.)

[0058] 3) Gelatin (from cows): NSC150 (manufactured by Nitta Gelatin Inc.)

[0059] 4) Gellan gum: KELCOGEL CG-LA (manufactured by Sankyo Co., Ltd.)

[0060] 5) Gellan gum (natural): KELCOGEL CG-HA (manufactured by Sankyo Co., Ltd.)

[0061] 6) Plasticizer: Glycerol (manufactured by Sakamoto Yakuhin Kogyo Co., Ltd.)

[0062] 7) Carrageenan (κ and ι mixed): GENUTINE 310-C (manufactured by Sankyo Co., Ltd.)

[0063] 8) Carrageenan (κ): GENUGEL carrageenan type WR-78-J (manufactured by Sankyo Co., Ltd.)

[0064] 9) Carrageenan (ι): GENUGEL carrageenan type CJ (manufactured by Sankyo Co., Ltd.)

[0065] 10) Carrageenan (λ): SATIAGEL (registered trademark) BDC 20 (manufactured by UNITEC FOODS Co., Ltd.)

[0066] 11) Sodium carboxymethyl cellulose: SUNROSE SLD-FM (manufactured by Nippon Paper Industries Co., Ltd.)

[0067] 12) Starch: Rice starch (manufactured by JAPAN CORN STARCH Co., Ltd.)

[0068] 13) Konjac powder: Finesuper Mannan (manufactured by Ogino Shoten Co., Ltd.)

[0069] 14) Isomaltooligosaccharide: Fibryxa (registered trademark) (manufactured by Hayashibara Co., Ltd.)

[0070] 15) Granulated sugar: Frost Sugar FS-2 (manufactured by Nisshin Seito Co., Ltd.)

[0071] 16) Polyethylene glycol: Polyethylene glycol 400 / 4000 (manufactured by FUJIFILM Wako Paper Co., Ltd.)

[0072] 17) Crystalline cellulose: CEOLUS (manufactured by Asahi Kasei Corporation)

[0073] 2. Preparation of the film solution

[0074] 2-1. Examples 1 to 6, Comparative Examples 3 to 5

[0075] Measure glycerol in a specified container, and while stirring, gradually add small amounts of galactose anhydride / sulfated galactose anhydride copolymer in sequence. After uniform dispersion, a galactose anhydride / sulfated galactose anhydride copolymer dispersion is obtained. Put purified water and the galactose anhydride / sulfated galactose anhydride copolymer dispersion into a mixing tank, and dissolve them while stirring. Then, add gelatin, and in Examples 5 and 6, further add gellan gum, and dissolve them while stirring. Then, stir and defoam to remove gas, and finally obtain the capsule film composition.

[0076] 2-2. Comparative Example 1

[0077] Put the remaining glycerol in a specified container, and while stirring, gradually add small amounts of konjac powder, sodium carboxymethyl cellulose, and rice starch in sequence, and stir until uniformly dispersed to obtain a dispersion. Measure purified water, a part of glycerol, and isomaltooligosaccharide in a mixing tank, and dissolve them while stirring. Then, add gelatin and dissolve it completely while stirring. Here, while continuing to stir, gradually add small amounts of the dispersion and dissolve it, and use stirring defoaming to remove gas, and finally obtain the capsule film composition.

[0078] 2-3. Comparative Example 2

[0079] Measure purified water, glycerol, and sugar in a specified container, and stir to dissolve them completely. Then, add polyethylene glycol, stir and dissolve it, then add crystalline cellulose and disperse it. Then, add gelatin while stirring to dissolve it uniformly to obtain the capsule film composition.

[0080] 2-4. Comparative Examples 6 to 9

[0081] Measure glycerol in a specified container, and while stirring, gradually add small amounts of carrageenan and disperse it uniformly to obtain a carrageenan dispersion. Put purified water and the carrageenan dispersion into a mixing tank, and dissolve them while stirring. Then, add gelatin and dissolve it while stirring, and use stirring defoaming to remove gas to obtain the capsule film composition.

[0082] 3. Capsule forming

[0083] Fill the capsule film composition prepared in 2 above into the spreader box of a rotary drum soft capsule forming machine, stretch and form a film about 0.8 mm on a rotating drum, and cool it to obtain a film sheet.

[0084] Next, while heating the surface of the film sheet in segments to bond it, just before stamping, fill MCT oil (medium-chain fatty acid oil) as the content liquid, and then dry the product formed by stamping to manufacture soft capsules.

[0085] 4. Drying

[0086] Feed the formed soft capsules into a drum dryer connected to the soft capsule molding machine, and dry them at a temperature of 20 - 30°C and a relative humidity of 5 - 50% for 8 - 60 hours to finally obtain the target soft capsules.

[0087] 5. Evaluation Tests

[0088] (1) Capsule Molding Property

[0089] Regarding the molding property of the capsules, judge whether the soft capsules can be molded using a rotary soft capsule molding machine.

[0090] ○: Can be molded

[0091] ×: Cannot be molded

[0092] (2) Chewability

[0093] The evaluation of chewability is carried out by 4 expert members and is evaluated in 3 stages: "soft and chewable", "chewable but slightly hard", and "hard and unable to chew".

[0094] ○: Soft and chewable

[0095] △: Chewable but slightly hard

[0096] ×: Hard and unable to chew

[0097] (3) Storage Stability

[0098] For each of the manufactured soft capsules, put 60 capsules each into glass bottles, seal the caps, and store them in a constant temperature and humidity chamber at room temperature of 40°C and humidity of 75% for 4 months, and evaluate the appearance of the soft capsules and the adhesion between the preparations or the adhesion to the container wall.

[0099] 1) Appearance

[0100] The appearance evaluation is to take out each sample from the storage and let it stand at room temperature for 24 hours, and visually confirm whether there is a color change (browning). The evaluation is carried out by 4 expert members and is evaluated in 3 stages: "no change", "slight change", and "obvious change".

[0101] 〇: No change

[0102] △: Slight change

[0103] ×: Obvious change

[0104] 2) Adhesiveness

[0105] The evaluation of adhesiveness is as follows: Each sample is taken out of the storage vault and left standing at room temperature for 24 hours. Then, the lid is opened, and the capsules contained in the bottle are placed on an aluminum tray. Those for which all the capsules can be taken out with only a gentle shake are evaluated as "no adhesion"; those for which a few capsules still remain adhered inside the bottle after only a gentle shake are evaluated as "slightly adhered"; and those for which the capsules cannot be taken out by gentle shaking alone are evaluated as "severely adhered".

[0106] 〇: No adhesion

[0107] △: Slightly adhered

[0108] ×: Severely adhered

[0109]

[0110]

[0111] It can be seen from Table 1-1 and Table 1-2 that the soft capsules of the present invention in Examples 1 to 6 have excellent capsule formability and good chewability due to their soft texture when chewed. Moreover, after being stored at 40°C for 4 months, there is no significant change in appearance, and no adhesion between capsules and no adhesion of capsules to the container are found, showing excellent storage stability.

[0112] On the other hand, although Comparative Example 1 in which the film contains starch and the like has good capsule formability and chewability, after being stored at 40°C for 4 months, its film shows obvious browning, and the phenomenon of coagulation between capsules and adhesion of capsules to the container are confirmed, so there is a problem with storage stability.

[0113] Comparative Example 2 in which the film contains sugar and the like is the same as Comparative Example 1. Although it has good capsule formability and chewability, there is a problem with storage stability.

[0114] Although Comparative Example 3 containing 3% of galactose dehydrate / sulfated galactose dehydrate copolymer and 39% of gelatin has good capsule formability, it is too hard to be easily bitten, and there is a problem with chewability.

[0115] In Comparative Example 4 containing 30% of galactose dehydrate / sulfated galactose dehydrate copolymer and 30% of gelatin, the solution solidifies when the capsule film composition is prepared, and there is a problem with capsule formability.

[0116] Although Comparative Example 5 containing 2% of galactose dehydrate / sulfated galactose dehydrate copolymer and 5% of gelatin can prepare a capsule film composition, the strength of the film sheet is weak, and the coagulation between the films during capsule formation is poor, resulting in a problem with capsule formability.

[0117] In Comparative Examples 6, 7, 8, and 9 in which the film contains known carrageenan, the solution solidified when the capsule film composition was prepared, and there were problems with capsule formability.

Claims

1. A chewable soft capsule, which is a chewable soft capsule having a capsule film and a capsule content; Among them, The capsule film contains the following component A and component B; Component A: gelatin, 1 to 35% by mass, Component B: dehydrated galactose / sulfated dehydrated galactose copolymer, 3 to 25% by mass.

2. The chewable soft capsule according to claim 1, wherein, Component B, namely the dehydrated galactose / sulfated dehydrated galactose copolymer, is a 3,6-dehydrated galactose / 3,6-dehydrated galactose-2-sulfate copolymer.

3. The chewable soft capsule according to claim 2, wherein, The molar ratio of 3,6-dehydrated galactose to 3,6-dehydrated galactose-2-sulfate, i.e., 3,6-AG-2-S / 3,6-AG, is 25 to 50%.

4. The chewable soft capsule according to any one of claims 1 to 3, wherein, The mass ratio of component A, namely gelatin, to component B, namely the dehydrated galactose / sulfated dehydrated galactose copolymer, i.e., A:B, is 1:25 to 13:

1.

5. The chewable soft capsule according to any one of claims 1 to 3, wherein, The capsule film contains a plasticizer.

6. The chewable soft capsule according to any one of claims 1 to 3, which is a roll-mode soft capsule preparation.

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