Synergistic bactericidal preservative composition as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of sterilization and anticorrosion compositions, and particularly relates to a synergistic sterilization and anticorrosion composition as well as a preparation method and application thereof. The synergistic bactericidal preservative composition comprises the following components in percentage by weight: 0.03%-0.1% of antimicrobial cationic quaternary ammonium salt, 0.01%-0.1% of an antioxidant, 0.01%-0.1% of a preservative and the balance of water. 0.05%-1% of antimicrobial glyceride; 0.1%-1% of antimicrobial p-hydroxybenzophenone; 0.2-5% of a humectant and the balance of deionized water. The sterilization and anticorrosion composition provided by the invention reduces the use amount of quaternary ammonium salt, and has the advantages of simple formula process, mild components and small irritation.

Description

Technical Field

[0001] The present invention belongs to the technical field of bactericidal and preservative compositions, and particularly relates to a synergistic bactericidal and preservative composition, a preparation method thereof, and an application thereof. Background Art

[0002] In the "Professional Requirements for Disinfection Wipes", it is stipulated that the dosage of quaternary ammonium salts shall not exceed 0.5%. In the "Technical Specifications for Cosmetic Safety 2015", it is clearly stipulated that the maximum allowable use concentration of quaternary ammonium salts in cosmetics is 0.1%. As a type of bactericide, cationic quaternary ammonium salts have broad-spectrum bactericidal properties. However, when the dosage of quaternary ammonium salts exceeds a certain range, it will still have a certain degree of irritation. When using wet wipes with a high content of quaternary ammonium salts frequently, it will still irritate the skin and even damage the skin. Therefore, reducing the dosage of quaternary ammonium salts in the formula is the future development trend.

[0003] Patent CN 112702914 A developed a synergistic antimicrobial mixture, which includes p-hydroxyacetophenone and glycerol caprylate. The solubility of glycerol caprylate in an aqueous system is poor, and a solubilizer needs to be added.

[0004] Patent CN 113893714 A invented a method for rapidly dissolving p-hydroxyacetophenone at low temperature.

[0005] Patent CN 114983842 A invented a compound preservative composition, including p-hydroxyacetophenone and glycerol caprylate, and using polyhydric alcohol for solubilization. The mixing temperature is 40 - 60°C, and the mixing time is 2 - 4h, with high energy consumption and long time consumption.

[0006] Patent CN 113244147 A invented a composite bactericidal wet wipe solution, using two active ingredients, benzalkonium chloride and polyhexamethylene guanidine, in combination. However, 2 - 4 parts of the active agent need to be added, with a large dosage and strong irritation.

[0007] Patent CN 115212129 A invented a sanitary lotion and wet wipes with rapid and efficient bactericidal properties, using 0.25 - 0.5% of quaternary ammonium salts in combination with biguanide and hydrogen peroxide. Compared with the quaternary ammonium salt content in Patent CN 113244147 A, the content is reduced, but the quaternary ammonium salts in this dosage still have irritation to the skin, etc.

[0008] Patent CN 102153675 A disclosed an N-p-hydroxyphenylmethyl chitosan quaternary ammonium salt. An N-p-hydroxyphenylmethyl quaternary ammonium salt fragment was synthesized on chitosan, and graft modification was carried out. Summary of the Invention

[0009] To solve the deficiencies of the prior art, the present invention provides a synergistic bactericidal and antiseptic composition, its preparation method and application. The bactericidal and antiseptic composition provided by the present invention reduces the dosage of quaternary ammonium salts, has a simple formulation process, mild ingredients and low irritation.

[0010] The technical solution provided by the present invention is as follows:

[0011] A synergistic bactericidal and antiseptic composition, comprising the following components in weight percentage: 0.03% - 0.1% of an antimicrobial cationic quaternary ammonium salt; 0.05% - 1% of an antimicrobial glyceride; 0.1% - 1% of an antimicrobial p-hydroxybenzophenone; 0.2 - 5% of a humectant, and the balance is deionized water.

[0012] In the above technical solution:

[0013] The antimicrobial glyceride is a non-toxic, safe and highly effective broad-spectrum antimicrobial agent, which can effectively inhibit the growth of a variety of foodborne pathogenic bacteria and spoilage microorganisms, and at the same time has a certain moisturizing and moisturizing effect, high non-toxic safety, friendly to humans and the environment, does not accumulate or remain in the human body, and can be finally metabolized into CO2 and H2O, with good adaptability;

[0014] The antimicrobial p-hydroxybenzophenone naturally exists in plants, has a certain inhibitory effect on Gram-positive bacteria, Gram-negative bacteria, fungi, etc., has low toxicity and low irritation, and at the same time has a certain antioxidant, sedative and soothing effect.

[0015] Based on the above technical solution:

[0016] Through the antimicrobial glyceride and the antimicrobial p-hydroxybenzophenone, the antimicrobial cationic quaternary ammonium salt can be synergistically enhanced, so as to ensure the bactericidal and antiseptic ability of the composition while reducing the content of the microbial cationic quaternary ammonium salt in the composition;

[0017] The inventor found that the antimicrobial cationic quaternary ammonium salt can increase the solubility of the antimicrobial glyceride in water, ensuring that the antimicrobial glyceride is applied to a composition with deionized water as the solvent;

[0018] Through the antimicrobial p-hydroxybenzophenone, not only the antimicrobial cationic quaternary ammonium salt is synergistically enhanced, but also the antimicrobial glyceride is synergistically enhanced, improving the bactericidal and antiseptic ability of the antimicrobial glyceride.

[0019] Specifically, the antimicrobial cationic quaternary ammonium salt is selected from any one or more of the following:

[0020] Single-chain quaternary ammonium salts: including single-chain quaternary ammonium salts with eight to twenty carbon atoms in the alkyl group;

[0021] Or double-chain quaternary ammonium salts, including double-chain quaternary ammonium salts with eight to fourteen carbon atoms in the alkyl group, where each of the eight to fourteen carbon atoms in the alkyl group is the same or different.

[0022] Preferably, the single-chain quaternary ammonium salt is selected from any one or more of dodecyl dimethyl benzyl ammonium chloride, dodecyl dimethyl ammonium bromide, dodecyl dimethyl phenoxyethyl ammonium bromide, cetylpyridinium chloride, dodecyl trimethyl ammonium chloride, dodecyl trimethyl ammonium bromide, tetradecyl trimethyl ammonium chloride, tetradecyl trimethyl ammonium bromide, hexadecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium bromide, or benzyl dimethyl [2-[2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy]ethyl] ammonium chloride.

[0023] Preferably, the double-chain quaternary ammonium salt is selected from any one or more of dioctyl dimethyl ammonium chloride, dioctyl dimethyl chlorobromide, didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium bromide, didodecyl dimethyl ammonium chloride, didodecyl dimethyl ammonium bromide, octyl decyl dimethyl ammonium chloride, or octyl decyl dimethyl ammonium bromide.

[0024] Specifically: The antimicrobial glyceride is selected from any one or more of octadecyl to tetradecyl glycerides.

[0025] Preferably: The antimicrobial glyceride is selected from any one or more of glycerol caprylate, glycerol caprate, glycerol caprylocaprate, or glycerol laurate.

[0026] Based on the above antimicrobial glycerides, it can not only play a good synergistic role with the antimicrobial cationic quaternary ammonium salt, but also have good solubility under the action of the antimicrobial cationic quaternary ammonium salt.

[0027] When the content of the antimicrobial glyceride is low, the antimicrobial performance in the aqueous system cannot be achieved. When the content is high, it will have certain irritation and increase the cost of the composition. Therefore, when the dosage of the antimicrobial cationic quaternary ammonium salt and the antimicrobial glyceride reaches a balance, it can not only meet the solubility in the aqueous system but also achieve excellent bactericidal performance.

[0028] Specifically, the antimicrobial p-hydroxybenzophenone is selected from any one or more of p-hydroxyalkylbenzophenones, and the number of alkyl groups is from one to six.

[0029] Preferably, the antimicrobial hydroxyacetophenone is selected from one or both of p-hydroxyacetophenone or p-hydroxybutyrophenone.

[0030] Similarly, the dosage of the antimicrobial p-hydroxybenzophenone and the antimicrobial glyceride and the antimicrobial cationic quaternary ammonium salt can not only meet the solubility in the aqueous system but also achieve excellent bactericidal performance.

[0031] Specifically, the humectant is selected from any one or more of alkyl polyols, the number of polyols is from two to four, and the alkyl is a branched-chain alkyl with two to four carbons.

[0032] The present invention also provides a preparation method of a synergistic bactericidal and antiseptic composition, comprising the following steps:

[0033] 1) Mix and heat an antimicrobial p-hydroxyacetophenone, a humectant and an appropriate amount of deionized water, and stir to dissolve;

[0034] 2) Mix and heat an antimicrobial cationic quaternary ammonium salt, an antimicrobial glyceride and an appropriate amount of deionized water, and stir to dissolve. Preferably, the heating temperature is 40-50 °C;

[0035] 3) Add the steps 1) and 2) into the remaining deionized water respectively, and stir to dissolve to obtain the product.

[0036] The present invention also provides the application of the above-mentioned synergistic bactericidal and antiseptic composition.

[0037] Specifically, it is used for preparing wet wipe liquid.

[0038] The synergistic bactericidal and antiseptic composition provided by the present invention not only has good bactericidal and antiseptic functions, but also has a very low quaternary ammonium salt content, and is particularly suitable for use in skin-friendly products, such as wet wipes.

[0039] Specifically, it is used to replace the bactericidal and antiseptic agent of the antimicrobial cationic quaternary ammonium salt.

[0040] Although the synergistic bactericidal and antiseptic composition provided by the present invention has a low quaternary ammonium salt content, under the synergistic action of the antimicrobial glyceride and the antimicrobial hydroxyacetophenone, the bactericidal and antiseptic effect is equivalent or even better, and it can replace the aqueous solution bactericidal and antiseptic agent with the antimicrobial cationic quaternary ammonium salt as the main agent. At the same time, the combination of the antimicrobial cationic quaternary ammonium salt, the antimicrobial glyceride and the antimicrobial p-hydroxyacetophenone can also be directly used to replace the antimicrobial cationic quaternary ammonium salt to prepare an aqueous solution preparation.

[0041] The beneficial effects of the present invention are as follows:

[0042] 1) Utilize the synergistic effect of the antimicrobial glyceride and the antimicrobial p-hydroxyacetophenone. The simultaneous addition of the two has a synergistic effect on the cationic quaternary ammonium salt, and can achieve a better bactericidal effect with less cationic quaternary ammonium salt dosage, thereby reducing irritation;

[0043] 2) Aiming at the solubility problem of the antimicrobial glyceride in the aqueous system, use the cationic quaternary ammonium salt to increase its solubility. A very good solubilization effect can be achieved with a low content of the cationic quaternary ammonium salt. Add a small amount of deionized water and heat at a low temperature of 40-50 °C, which can accelerate its solubilization efficiency and will not precipitate when added to the aqueous system;

[0044] 3) The formulation process is simple, the components are mild, and the irritation is small. Detailed implementation mode

[0045] The principles and features of the present invention will be described below. The examples given are only used to explain the present invention and are not intended to limit the scope of the present invention.

[0046] Unless otherwise specified, the test methods used in the examples are all conventional methods; the materials, reagents, etc. used, unless otherwise specified, are reagents and materials that can be obtained from commercial channels.

[0047] The measurement methods in each example are all calculated by weight percentage.

[0048] Example 1

[0049] This example provides a method for dissolving antimicrobial glycerides, which includes:

[0050] S1: Heat 0.03% cetylpyridinium chloride, 0.15% glycerol caprylate, and 1% deionized water at 45°C and rapidly stir to dissolve for 2 min.

[0051] S2: Add the solution obtained in S1 to the remaining deionized water, rapidly stir for 5 min, and observe the stability.

[0052] Example 2

[0053] This example provides a method for dissolving antimicrobial glycerides, which includes:

[0054] S1: Heat 0.05% cetylpyridinium chloride, 0.2% glycerol caprylate, and 2% deionized water at 45°C and rapidly stir to dissolve for 2 min.

[0055] S2: Add the solution obtained in S1 to the remaining deionized water, rapidly stir for 5 min, and observe the stability.

[0056] Example 3

[0057] This example provides a method for dissolving antimicrobial glycerides, which includes:

[0058] S1: Heat 0.1% cetylpyridinium chloride, 0.5% glycerol caprylate, and 5% deionized water at 45°C and rapidly stir to dissolve for 2 min.

[0059] S2: Add the solution obtained in S1 to the remaining deionized water, rapidly stir for 5 min, and observe the stability.

[0060] Example 4

[0061] This example provides a method for dissolving antimicrobial glycerides, which includes:

[0062] S1: Heat 0.05% didodecyldimethylammonium chloride, 0.2% glyceryl caprate, and 2% deionized water at 45°C, and rapidly stir to dissolve for 2 min.

[0063] S2: Add the solution obtained in S1 to the remaining deionized water, rapidly stir for 5 min, and observe the stability.

[0064] Example 5

[0065] This example provides a method for dissolving an antimicrobial glyceride, which includes:

[0066] S1: Heat 0.1% dodecyl dimethyl benzyl ammonium chloride, 0.4% glyceryl caprate, and 5% deionized water at 45°C, and rapidly stir to dissolve for 2 min.

[0067] S2: Add the solution obtained in S1 to the remaining deionized water, rapidly stir for 5 min, and observe the stability.

[0068] Example 6

[0069] This example provides a method for dissolving an antimicrobial glyceride, which includes:

[0070] S1: Heat 0.05% cetylpyridinium chloride, 0.2% glyceryl laurate, and 2% deionized water at 45°C, and rapidly stir to dissolve for 2 min.

[0071] S2: Add the solution obtained in S1 to the remaining deionized water, rapidly stir for 5 min, and observe the stability.

[0072] Comparative Example 1

[0073] This comparative example provides a method for dissolving an antimicrobial glyceride, which includes:

[0074] S1: Heat 0.05% cetylpyridinium chloride, 0.2% octanoic acid glyceride at 45°C, and rapidly stir to dissolve for 2 min.

[0075] S2: Add the solution obtained in S1 to the remaining deionized water, rapidly stir for 5 min, and observe the stability.

[0076] Comparative Example 2

[0077] This comparative example provides a method for dissolving an antimicrobial glyceride, which includes:

[0078] S1: Heat 0.2% octanoic acid glyceride, 2% deionized water at 45°C, and rapidly stir to dissolve for 2 min.

[0079] S2: Add the solution obtained in S1 to the remaining deionized water, rapidly stir for 5 min, and observe the stability.

[0080] Comparative Example 3

[0081] This comparative example provides a method for dissolving antimicrobial glycerides, which includes:

[0082] S1: Rapidly stir and dissolve 0.05% cetylpyridinium chloride, 0.2% glycerol caprylate, and 2% deionized water at room temperature for 2 min.

[0083] S2: Add the solution obtained in S1 to the remaining deionized water, rapidly stir for 5 min, and observe the stability.

[0084] Stability of Examples 1-6 and Comparative Examples 1-3:

[0085] Stability Example 1 Normal, no precipitation and delamination Example 2 Normal, no precipitation and delamination Example 3 Normal, no precipitation and delamination Example 4 Normal, no precipitation and delamination Example 5 Normal, no precipitation and delamination Example 6 Normal, no precipitation and delamination Comparative Example 1 Oil droplets precipitate Comparative Example 2 Unable to dissolve, delamination Comparative Example 3 Oil droplets precipitate

[0086] As can be seen from the above table, when solubilizing antimicrobial glycerides such as glycerol caprylate alone using quaternary ammonium salts, water, or without heating, varying degrees of stability problems occur. However, the method of using quaternary ammonium salt + water + low-temperature heating not only speeds up the dissolution efficiency but also solves the stability problem of the aqueous solution preparation.

[0087] Example 7

[0088] This example provides a synergistic bactericidal and preservative composition, which includes the following components by mass percentage:

[0089] Cetylpyridinium chloride 0.03%

[0090] Glycerol caprylate 0.3%

[0091] p-Hydroxyacetophenone 0.5%

[0092] Glycerol 1.5%

[0093] Deionized water To 100

[0094] Preparation method of the synergistic bactericidal and preservative composition provided in this example:

[0095] S1: Heat p-hydroxyacetophenone, glycerol, and a small amount of deionized water at 80 °C, stir and dissolve;

[0096] S2: Heat cetylpyridinium chloride, glycerol caprylate, and a small amount of deionized water at 45 °C, stir and dissolve;

[0097] S3: Add S1 and S2 successively to the remaining deionized water, stir and dissolve.

[0098] Example 8

[0099] This example provides a synergistic bactericidal and preservative composition, which includes the following components by mass percentage:

[0100] Cetylpyridinium chloride 0.04%

[0101] Glycerol caprylate 0.2%

[0102] p-Hydroxyacetophenone 0.4%

[0103] Glycerol 1%

[0104] Deionized water To 100

[0105] Preparation method of the synergistic bactericidal and preservative composition provided by this example:

[0106] S1: Heat p-hydroxyacetophenone, glycerol and a small amount of deionized water at 80 °C and stir to dissolve;

[0107] S2: Heat cetylpyridinium chloride, glycerol caprylate and a small amount of deionized water at 45 °C and stir to dissolve;

[0108] S3: Add S1 and S2 to the remaining deionized water successively and stir to dissolve.

[0109] Example 9

[0110] This example provides a synergistic bactericidal and preservative composition, which includes the following components by mass percentage:

[0111] Dodecyldimethylbenzylammonium chloride 0.04%

[0112] Glycerol caprylate 0.2%

[0113] p-Hydroxyacetophenone 0.4%

[0114] Glycerol 1%

[0115] Deionized water To 100

[0116] Preparation method of the synergistic bactericidal and preservative composition provided by this example:

[0117] S1: Heat p-hydroxyacetophenone, glycerol and a small amount of deionized water at 80 °C and stir to dissolve;

[0118] S2: Heat dodecyldimethylbenzylammonium chloride, glycerol caprylate and a small amount of deionized water at 45 °C and stir to dissolve;

[0119] S3: Add S1 and S2 to the remaining deionized water successively and stir to dissolve.

[0120] Example 10

[0121] This example provides a synergistic bactericidal and preservative composition, which includes the following components by mass percentage:

[0122] Didecyldimethylammonium chloride 0.04%

[0123] Glycerol caprylate 0.2%

[0124] p-Hydroxyacetophenone 0.4%

[0125] Glycerol 1%

[0126] Deionized water To 100

[0127] The preparation method of the synergistic bactericidal and preservative composition provided in this example:

[0128] S1: Heat p-hydroxyacetophenone, glycerol and a small amount of deionized water at 80 °C and stir to dissolve;

[0129] S2: Heat didecyldimethylammonium chloride, glycerol caprylate and a small amount of deionized water at 45 °C and stir to dissolve;

[0130] S3: Add S1 and S2 to the remaining deionized water successively and stir to dissolve.

[0131] Example 11

[0132] This example provides a synergistic bactericidal and preservative composition, which includes the following components by mass percentage:

[0133] Cetylpyridinium chloride, dodecyldimethylbenzylammonium chloride, and didecyldimethylammonium chloride in total 0.04%, and the weight ratio of the three is 2:1:1.

[0134] Glycerol caprylate 0.2%

[0135] p-Hydroxyacetophenone 0.4%

[0136] Glycerol 1%

[0137] Deionized water To 100

[0138] The preparation method of the synergistic bactericidal and preservative composition provided in this example:

[0139] S1: Heat p-hydroxyacetophenone, glycerol and a small amount of deionized water at 80 °C and stir to dissolve;

[0140] S2: Heat cetylpyridinium chloride, dodecyldimethylbenzylammonium chloride, didecyldimethylammonium chloride, glycerol caprylate and a small amount of deionized water at 45 °C and stir to dissolve;

[0141] S3: Add S1 and S2 to the remaining deionized water successively and stir to dissolve.

[0142] Example 12

[0143] This example provides a synergistic bactericidal and antiseptic composition, which comprises the following components by mass percentage:

[0144] Cetylpyridinium chloride 0.05%

[0145] Glycerol caprylate 0.15%

[0146] p-Hydroxyacetophenone 0.3%

[0147] Glycerol 0.8%

[0148] Deionized water To 100

[0149] The preparation method of the synergistic bactericidal and antiseptic composition provided in this example:

[0150] S1: Heat p-hydroxyacetophenone, glycerol and a small amount of deionized water at 80 °C and stir to dissolve;

[0151] S2: Heat cetylpyridinium chloride, glycerol caprylate and a small amount of deionized water at 45 °C,

[0152] Stir to dissolve;

[0153] S3: Add S1 and S2 to the remaining deionized water successively and stir to dissolve.

[0154] Example 13

[0155] This example provides a synergistic bactericidal and antiseptic composition, which comprises the following components by mass percentage:

[0156] Cetylpyridinium chloride 0.1%

[0157] Glycerol caprylate 0.1%

[0158] p-Hydroxyacetophenone 0.2%

[0159] Glycerol 0.5%

[0160] Deionized water To 100

[0161] The preparation method of the synergistic bactericidal and antiseptic composition provided in this example:

[0162] S1: Heat p-hydroxyacetophenone, glycerol and a small amount of deionized water at 80 °C and stir to dissolve;

[0163] S2: Heat cetylpyridinium chloride, glycerol caprylate and a small amount of deionized water at 45 °C,

[0164] Stir to dissolve;

[0165] S3: Add S1 and S2 to the remaining deionized water successively and stir to dissolve.

[0166] Comparative Example 4

[0167] This comparative example provides a bactericidal and antiseptic composition, which includes the following components by mass percentage:

[0168] Cetylpyridinium chloride 0.04%

[0169] Deionized water To 100

[0170] The preparation method of the bactericidal and antiseptic composition provided by this comparative example:

[0171] Add cetylpyridinium chloride to the remaining deionized water and stir to dissolve.

[0172] Comparative Example 5

[0173] This comparative example provides a bactericidal and antiseptic composition, which includes the following components by mass percentage:

[0174] Cetylpyridinium chloride 0.04%

[0175] Glycerol monocaprylate 0.2%

[0176] Deionized water To 100

[0177] The preparation method of the bactericidal and antiseptic composition provided by this comparative example:

[0178] S1: Heat cetylpyridinium chloride, glycerol monocaprylate and a small amount of deionized water at 45 °C,

[0179] Stir to dissolve;

[0180] S2: Add S1 to the remaining deionized water and stir to dissolve.

[0181] Comparative Example 6

[0182] This comparative example provides a bactericidal and antiseptic composition, which includes the following components by mass percentage:

[0183] Cetylpyridinium chloride 0.04%

[0184] p-Hydroxyacetophenone 0.4%

[0185] Glycerol 1%

[0186] Deionized water To 100

[0187] The preparation method of the bactericidal and antiseptic composition provided by this comparative example:

[0188] S1: Heat p - hydroxyacetophenone, glycerol and a small amount of deionized water to 80 °C and stir to dissolve.

[0189] S2: Add cetylpyridinium chloride to the remaining deionized water and stir to dissolve.

[0190] S3: Add S1 to S2 and continue to stir to dissolve.

[0191] Comparative Example 7

[0192] This comparative example provides a bactericidal and preservative composition, which includes the following components by mass percentage:

[0193] Dodecyldimethylbenzylammonium chloride 0.04%

[0194] Deionized water To 100

[0195] The preparation method of the bactericidal and preservative composition provided by this comparative example:

[0196] Add dodecyldimethylbenzylammonium chloride to the remaining deionized water and stir to dissolve.

[0197] Comparative Example 8

[0198] This comparative example provides a bactericidal and preservative composition, which includes the following components by mass percentage:

[0199] Didecyldimethylammonium chloride 0.04%

[0200] Deionized water To 100

[0201] The preparation method of the bactericidal and preservative composition provided by this comparative example:

[0202] Add didecyldimethylammonium chloride to the remaining deionized water and stir to dissolve.

[0203] Comparative Example 9

[0204] This comparative example provides a bactericidal and preservative composition, which includes the following components by mass percentage:

[0205] Cetylpyridinium chloride, dodecyldimethylbenzylammonium chloride, and didecyldimethylammonium chloride in total 0.04%, and the weight ratio of the three is 2:1:1.

[0206] Deionized water To 100

[0207] The preparation method of the bactericidal and preservative composition provided by this comparative example:

[0208] Add cetylpyridinium chloride, dodecyldimethylbenzylammonium chloride, and didecyldimethylammonium chloride to the remaining deionized water and stir to dissolve.

[0209] The bactericidal and preservative composition obtained by compounding the above Examples 7-13 and Comparative Examples 4-9 was made into wet wipe products of standard size (15 cm by 20 cm). The wet wipe material was 100% pure cotton, and the addition amount of the bactericidal and preservative composition was 3.5 times that of the wet wipe material. The overall weight of the wet wipe product was about 6.5 g per piece. Then, after aging for 14 days at 54 °C, the bactericidal performance was tested. Referring to GB 15979-2002 Hygienic Standards for Disposable Sanitary Products, the bactericidal performance against Staphylococcus aureus (ATCC6538), Escherichia coli (ATCC 8739), and Candida albicans (ATCC 10231) was tested for 2 minutes.

[0210] The bactericidal performance of the aged Examples and Comparative Examples was tested, and the test results are as follows:

[0211]

[0212] As can be seen from the table, adding three antimicrobial agents simultaneously has excellent bactericidal performance. The compounding of antimicrobial glycerides and antimicrobial hydroxyacetophenone has an excellent synergistic effect on quaternary ammonium salts, especially in terms of antifungal. Since the quaternary ammonium salt content is generally about 0.1% in the prior art, it can be seen that the addition of antimicrobial glycerides and antimicrobial p-hydroxyacetophenone significantly reduces the addition amount of antimicrobial cationic quaternary ammonium salts in the system, and can achieve better bactericidal effects with less quaternary ammonium salt, reducing the irritation of quaternary ammonium salts to the skin / eyes.

[0213] Similarly, some of the examples were made into wet wipe products of the same standard size (15 cm by 20 cm), and then the anti-corrosion efficacy experiment was carried out. Referring to the microbial anti-corrosion efficacy test of the United States Pharmacopoeia USP2023(51), the test strains were: mixed bacteria (Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 9027, and Burkholderia cepacia ATCC 25416) and mixed molds and yeasts (Candida albicans ATCC 10231 and Aspergillus brasiliensis ATCC 16404). The mixed bacteria and mixed molds and yeasts were inoculated separately at one time for challenge, cultured at an appropriate temperature, and the mixed bacteria and mixed molds and yeasts were inoculated again on the 14th day. Samples were taken on the 7th, 14th, 21st, and 28th days after the first inoculation to detect the bacterial count, and it was judged whether the product passed the anti-corrosion challenge test. The test results are as follows:

[0214]

[0215]

[0216] As shown in the above table, Examples 7, 8, 11, 12, and 13 all passed the anti-corrosion efficacy test, indicating that the synergistic bactericidal and anti-corrosion composition has excellent anti-corrosion performance.

[0217] The effects of Examples 9 and 10 are better than those of Example 8, which will not be elaborated here.

[0218] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims

1. A synergistic bactericidal and preservative composition, characterized in that, Comprising the following components in weight percentage: 0.03% - 0.1% of an antimicrobial cationic quaternary ammonium salt; 0.05% - 1% of an antimicrobial glyceride; 0.1% - 1% of an antimicrobial p-hydroxybenzophenone; 0.2 - 5% of a humectant, and the balance being deionized water.

2. The synergistic bactericidal and preservative composition according to claim 1, wherein The antimicrobial cationic quaternary ammonium salt is selected from any one or more of the following: Single-chain quaternary ammonium salts: including single-chain quaternary ammonium salts with 8 to 20 carbon atoms in the alkyl group; Or double-chain quaternary ammonium salts: including double-chain quaternary ammonium salts with 8 to 14 carbon atoms in the alkyl group, wherein the 8 to 14 carbon atoms in each alkyl group are the same or different.

3. The synergistic bactericidal and preservative composition according to claim 2, characterized in that: The single-chain quaternary ammonium salt is selected from any one or more of dodecyl dimethyl benzyl ammonium chloride, dodecyl dimethyl ammonium bromide, dodecyl dimethyl phenoxyethyl ammonium bromide, cetylpyridinium chloride, dodecyl trimethyl ammonium chloride, dodecyl trimethyl ammonium bromide, tetradecyl trimethyl ammonium chloride, tetradecyl trimethyl ammonium bromide, hexadecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium bromide, or benzyl dimethyl [2-[2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy]ethyl] ammonium chloride; The double-chain quaternary ammonium salt is selected from any one or more of dioctyl dimethyl ammonium chloride, dioctyl dimethyl chloro-bromide, didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium bromide, didodecyl dimethyl ammonium chloride, didodecyl dimethyl ammonium bromide, octyl decyl dimethyl ammonium chloride, or octyl decyl dimethyl ammonium bromide.

4. The synergistic bactericidal and preservative composition according to claim 2 or 3, characterized in that: The antimicrobial glyceride is selected from any one or more of glycerides of 8 to 14 carbon fatty acids.

5. The synergistic bactericidal and preservative composition according to claim 4, wherein: The antimicrobial glyceride is selected from any one or more of glycerol caprylate, glycerol caprate, glycerol caprylate / caprate, or glycerol laurate.

6. The synergistic bactericidal and preservative composition according to claim 1, wherein: The antimicrobial p-hydroxybenzophenone is selected from any one or more of p-hydroxyalkylphenones, and the number of alkyl groups is from one to six.

7. The synergistic bactericidal and antiseptic composition according to claim 6, wherein: The antimicrobial p-hydroxybenzophenone is selected from one or both of p-hydroxyacetophenone or p-hydroxybutyrophenone.

8. The synergistic bactericidal and preservative composition according to claim 1, characterized in that: The humectant is selected from any one or more of alkyl polyols, the number of polyols is two to four, and the alkyl group is a branched-chain alkyl group with two to four carbon atoms.

9. A method for preparing the synergistic bactericidal and antiseptic composition according to any one of claims 1 to 8, characterized in that, Comprising the following steps: 1) Mix and heat the antimicrobial p-hydroxybenzophenone, the humectant, and an appropriate amount of deionized water, and stir to dissolve; 2) Mix and heat the antimicrobial cationic quaternary ammonium salt, the antimicrobial glyceride, and an appropriate amount of deionized water, and stir to dissolve; 3) Add the mixtures obtained in steps 1) and 2) respectively to the remaining deionized water, stir to dissolve, and obtain the product.

10. The use of the synergistic bactericidal and preservative composition according to any one of claims 1 to 8, characterized in that: It is used for preparing wet wipe liquid; Or, it is used as a bactericidal and preservative to replace the antimicrobial cationic quaternary ammonium salt.

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