Rapid tumor sampling device

Abstract

The rapid tumor sampling device comprises a lower cylinder body and an upper cylinder body, one side of the top of the upper cylinder body is communicated with an adsorption tube through an opening, a first ring and a second ring are fixedly arranged on the inner wall of the top of the adsorption tube, and a diaphragm is bonded to the inner wall of the corresponding side of the first ring and the second ring; a cutting wire is inserted into a gap between the first ring and the second ring, and the outer walls of the two ends of the cutting wire penetrate through one side of the top of the adsorption pipe to be fixedly connected with the outer wall of the top of the first sliding block. According to the device, through organic combination of directional cutting mechanical design and negative-pressure adsorption positioning, a quick, accurate and low-trauma acquisition mode of a tumor sample is realized, and the controllability of the cutting direction and the path stability are obviously superior to those of a traditional clamping or puncture needle rotary cutting technology; the device is especially suitable for scenes with strict requirements on operation space and precision, such as deep tumor biopsy, and an efficient and safe standardized sampling solution is provided for clinic.

Description

Technical Field

[0001] The present invention relates to the technical field of sampling equipment, and particularly relates to a rapid tumor sampling device. Background Art

[0002] Sampling of tumor tissues is a key step in the pathological diagnosis and precision medicine of breast cancer. Especially in minimally invasive breast surgery and ultrasound-guided biopsy, the sampling device needs to meet the requirements of rapidity, low invasiveness, and high reliability. Due to the diversity of the texture of breast cancer tissues (including fibrotic, fatty, and calcified regions) and the complex anatomical structures such as adjacent blood vessels and mammary ducts, higher challenges are posed to sampling techniques. Currently, the commonly used sampling techniques in clinics mainly include needle aspiration (such as vacuum-assisted breast biopsy, VAB), biopsy forceps clamping, and rotational cutting, etc., but there are still the following limitations:

[0003] Traditional rotational cutting needles (such as Tru-Cut needles) rely on transverse shear or helical motion to sever breast cancer tissues. The cutting direction is easily affected by the operator's technique. Especially when dealing with breast tissues with high fibrosis or fat content, tissue sliding may cause the cutting path to deviate. This non-directional cutting not only reduces the sample integrity but also may accidentally injure the surrounding healthy breast tissues or blood vessels, increasing the risk of intraoperative bleeding and local hematoma.

[0004] Although existing negative pressure adsorption sampling devices can fix breast cancer tissues to a certain extent, the cutting execution mechanisms (such as blades or high-frequency electrosurgical knives) mostly use oblique or transverse motion, and the included angle between the cutting direction and the tissue adsorption direction is small, resulting in an increase in the severance resistance. Especially for breast cancer tissues with softer texture or containing microcalcification points, such designs are prone to cause sample stretching deformation or even fragmentation, making it difficult to retain the complete pathological structure and affecting the accuracy of subsequent pathological typing (such as invasive ductal carcinoma or lobular carcinoma) and molecular marker detection.

[0005] The space of deep breast cancer lesions or axillary lymph node metastasis regions is limited, and extremely high requirements are placed on the precision and stroke efficiency of the sampling device. Traditional devices are difficult to achieve rapid and directional cutting in narrow cavities. The extended operation time may exacerbate the patient's discomfort and increase the risk of infection or tissue damage. In addition, although some cutting wire techniques attempt to achieve tissue severance through single-point traction, they lack rigid constraints on the movement trajectory of the cutting wire and are difficult to adapt to the variable characteristics of breast cancer tissues.

[0006] In view of the above problems, there is an urgent need for a sampling device that can rapidly, accurately, and minimally invasively obtain breast cancer samples to improve the biopsy efficiency, reduce complications, and provide reliable support for the early diagnosis and individualized treatment of breast cancer. For this reason, we propose a rapid tumor sampling device, which is particularly suitable for breast cancer-related scenarios. Summary of the Invention

[0007] The object of the present invention is to provide a rapid tumor sampling device to solve the above deficiencies in the art.

[0008] To achieve the above object, the present invention provides the following technical solution: A rapid tumor sampling device includes a lower cylinder and an upper cylinder. One side of the top of the upper cylinder is communicated with an adsorption tube through an opening. The inner walls of the top of the adsorption tube are respectively fixedly provided with a first ring and a second ring. A diaphragm is adhesively connected to the inner walls of the first ring and the second ring corresponding to each other. A cutting wire is inserted into the gap between the first ring and the second ring. Both ends of the outer wall of the cutting wire pass through one side of the top of the adsorption tube and are fixedly connected to the outer wall of the top of the first slider. One side of the top of the upper cylinder is fixedly provided with an excitation tube. The inner walls of the excitation tube are respectively slidably connected with a first slider and a second slider. One end of the bottom of the first slider is fixedly provided with a spring. The other end of the spring is fixedly connected to the outer wall of the second slider.

[0009] As a preferred technical solution of the present invention: A first positioning hole is opened on the outer wall of one side of the first slider. A second positioning hole is opened on the outer wall of one side of the excitation tube. A first pin is inserted into the second positioning hole.

[0010] As a preferred technical solution of the present invention: A vertically downward chute is opened on the outer wall of one side of the excitation tube. A through first fixing hole is opened on the outer wall of one side of the second slider. A second fixing hole is opened on the inner wall of one side of the bottom of the excitation tube. A chute of a suitable size is inserted into the first fixing hole. The outer wall of the second pin is slidably connected to the inner wall of the chute.

[0011] As a preferred technical solution of the present invention: An external thread interface is opened on the outer wall of the top of the lower cylinder. An internal thread interface is opened on the inner wall of the bottom of the upper cylinder. The top of the lower cylinder is threadedly connected to the bottom of the upper cylinder. The top of the lower cylinder is equipped with a matching internal thread sealing cover through the external thread interface.

[0012] As a preferred technical solution of the present invention: A strip-shaped guiding cover is fixedly provided on the outer wall of one side of the top of the adsorption tube. Both ends of the cutting wire are connected to the outer wall of the top of the first slider through the strip-shaped guiding cover.

[0013] As a preferred technical solution of the present invention: A rubber piston is slidably connected to the inner walls of the lower cylinder and the upper cylinder. A vertically downward pull rod is fixedly provided on the outer wall of the bottom of the rubber piston. A push-pull piece is fixedly provided at one end of the bottom of the pull rod.

[0014] As a preferred technical solution of the present invention: Guide grooves are respectively provided on the inner walls of the first ring and the second ring. The cutting wire is slidably arranged along the guide grooves. The depth of the guide grooves is adapted to the diameter of the cutting wire to enhance the path stability of the cutting wire during the extraction process.

[0015] As a preferred technical solution of the present invention: scale marks are provided on the outer wall of the lower cylinder body, and the scale marks correspond to the moving position of the rubber piston, and are used to indicate the magnitude of the negative pressure in the cylinder to assist the operator in precisely controlling the adsorption force.

[0016] In the above technical solution, the technical effects and advantages provided by the present invention are as follows:

[0017] The cutting wire quickly withdraws along a preset path through the gap between the first ring and the second ring, ensuring that the cutting direction is consistent with the negative pressure suction direction of the adsorption tube. This design makes the cutting force concentrated on the target tissue area fixed by adsorption, avoids damage to the surrounding healthy tissues caused by tissue sliding during the cutting process, and significantly reduces the risk of intraoperative bleeding and postoperative complications;

[0018] The cutting wire moves at a high speed in the vertical direction under the drive of the spring and instantly completes the vertical disconnection of the adsorbed tissue. The vertical cutting direction can maximize the use of the tension of the cutting wire, achieve efficient cutting with the smallest contact area, and avoid tissue tearing caused by traditional rotary cutting or horizontal shearing, especially suitable for obtaining tumor samples with fragile texture.

[0019] Through the organic combination of the directional cutting mechanics design and the negative pressure adsorption positioning, the present device realizes a fast, precise and minimally invasive way to obtain tumor samples. The controllability of the cutting direction and the path stability are significantly better than the traditional forceps extraction or puncture needle rotary cutting technology, especially suitable for scenarios with strict requirements for operation space and precision such as endoscopic surgery and deep tumor biopsy, providing a highly efficient and safe standardized sampling solution for clinical practice. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments recorded in the present invention. For those of ordinary skill in the art, other drawings can also be obtained according to these drawings.

[0021] Figure 1 Schematic perspective view of a tumor rapid sampling device of the present invention;

[0022] Figure 2 Schematic structural view of the lower cylinder body of a tumor rapid sampling device of the present invention;

[0023] Figure 3 Schematic structural view of the upper cylinder body of a tumor rapid sampling device of the present invention;

[0024] Figure 4 Schematic structural view of the excitation tube of a tumor rapid sampling device of the present invention;

[0025] Figure 5Schematic diagram of the cutting wire structure of a rapid tumor sampling device of the present invention;

[0026] Figure 6 Schematic cross-sectional structure diagram of the upper cylinder of a rapid tumor sampling device of the present invention;

[0027] Figure 7 For a rapid tumor sampling device of the present invention Figure 6 Enlarged schematic diagram of part A in the structure;

[0028] Figure 8 For a rapid tumor sampling device of the present invention Figure 6 Enlarged structure diagram of part B in the structure.

[0029] Explanation of reference numerals:

[0030] 1 Lower cylinder, 2 Upper cylinder, 3 Suction tube, 4 First ring, 5 Second ring, 6 Diaphragm, 7 Strip-shaped guide cover, 8 Excitation tube, 9 First slider, 10 Second slider, 11 Spring, 12 First positioning hole, 13 Second positioning hole, 14 First pin, 15 First fixing hole, 16 Second fixing hole, 17 Second pin, 18 Slide groove, 19 Cutting wire, 20 Rubber piston, 21 Pull rod, 22 Push-pull piece. Detailed implementation manners

[0031] The following will disclose multiple embodiments of the present invention with diagrams, and many practical details will be described together in the following narrative. However, it should be understood that these practical details are not used to limit the present invention. That is to say, in some embodiments of the present invention, these practical details are not necessary. In addition, for the sake of simplifying the diagrams, some well-known and commonly used structures and components will be shown in a simple schematic manner in the diagrams.

[0032] In addition, in the present invention, descriptions such as "first" and "second" are only for descriptive purposes, and do not specifically refer to the meaning of order or sequence, nor are they used to limit the present invention. They are merely used to distinguish components or operations described with the same technical terms, and cannot be understood as indicating or implying their relative importance or implicitly indicating the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include at least one of such features. In addition, the technical solutions between various embodiments can be combined with each other, but it must be based on the fact that those of ordinary skill in the art can implement them. When the combination of technical solutions results in contradictions or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the protection scope required by the present invention.

[0033] Embodiment 1:

[0034] Refer to the attached instructions Figures 1-8, this embodiment provides a rapid tumor sampling device, which consists of an adsorption structure and a cutting structure. The adsorption structure includes a lower cylinder 1 and an upper cylinder 2. An external thread interface is provided on the outer wall of the top of the lower cylinder 1, and an internal thread interface is provided on the inner wall of the bottom of the upper cylinder 2. The top of the lower cylinder 1 is threadedly connected to the bottom of the upper cylinder 2. The top of the lower cylinder 1 is equipped with a matching internal thread sealing cover through the external thread interface. A rubber piston 20 is slidably connected to the inner walls of the lower cylinder 1 and the upper cylinder 2. A vertically downward pull rod 21 is fixedly provided on the outer wall of the bottom of the rubber piston 20, and a push-pull piece 22 is fixedly provided at one end of the bottom of the pull rod 21. A scale mark is provided on the outer wall of the lower cylinder 1, and the scale mark corresponds to the moving position of the rubber piston 20, which is used to indicate the magnitude of the negative pressure in the cylinder to assist the operator in precisely controlling the adsorption force. A strip-shaped guiding cover 7 is fixedly provided on one side of the outer wall of the top of the adsorption tube 3, and both ends of the cutting wire 19 are connected to the outer wall of the top of the first slider 9 through the strip-shaped guiding cover 7.

[0035] Cutting structure: One side of the top of the upper cylinder 2 is communicated with an adsorption tube 3 through an opening. The end face of the adsorption tube 3 away from the upper cylinder 2 is a puncture and cutting surface. The inner walls of the top of the adsorption tube 3 are respectively fixedly provided with a first ring 4 and a second ring 5. Guide grooves are respectively provided on the inner walls of the first ring 4 and the second ring 5. The cutting wire 19 is slidably arranged along the guide grooves. The depth of the guide grooves is adapted to the diameter of the cutting wire 19 to enhance the path stability of the cutting wire 19 during the extraction process. A diaphragm 6 is adhesively bonded to the inner walls of the corresponding sides of the first ring 4 and the second ring 5. The cutting wire 19 is inserted into the gap between the first ring 4 and the second ring 5. Both ends of the outer wall of the cutting wire 19 pass through one side of the top of the adsorption tube 3 and are fixedly connected to the outer wall of the top of the first slider 9. A firing tube 8 is fixedly provided on one side of the outer wall of the top of the upper cylinder 2. A first slider 9 and a second slider 10 are respectively slidably connected to the inner wall of the firing tube 8. A spring 11 is fixedly provided at one end of the bottom of the first slider 9, and the other end of the spring 11 is fixedly connected to the outer wall of the second slider 10. A first positioning hole 12 is provided on one side of the outer wall of the first slider 9, and a second positioning hole 13 is provided on one side of the outer wall of the firing tube 8. A first pin 14 is inserted into the second positioning hole 13. A vertically downward sliding groove 18 is provided on one side of the outer wall of the firing tube 8. A through first fixing hole 15 is provided on one side of the outer wall of the second slider 10. A second fixing hole 16 is provided on the inner wall of the bottom of one side of the firing tube 8. The first fixing hole 15 is inserted with a matching sliding groove 18, and the outer wall of the second pin 17 is slidably connected to the inner wall of the sliding groove 18.

[0036] The working principle of the present invention:

[0037] Refer to the attached instructions Figures 1-8, tighten the lower cylinder body 1 and the upper cylinder body 2, insert the second pin 14 into the first positioning hole 12 through the second positioning hole 13 to lock the first slider 9, and then press down the second pin 17 to move the second slider 10 downward. When the second slider 10 moves to the specified position, insert the second pin 17 through the first fixing hole 15 into the second fixing hole 16. At this time, the cutting wire 19 is in a state of waiting to be activated;

[0038] Then, attach the opening of the adsorption tube 3 to the surface of the tumor, pull the push-pull piece 22 up and down to drive the rubber piston 20 to move downward, creating a negative pressure inside the cylinder to adsorb the tissue. Since the end face of the adsorption tube 3 is a cutting surface, the tumor tissue is sucked into the adsorption tube 3 through the adsorption tube 3, and the tumor tissue passes through the diaphragm 6 and enters the cavity inside the adsorption tube 3;

[0039] Then pull out the first pin 14, and the spring 11 releases its elastic force to push the first slider 9 downward. The cutting wire 19 quickly withdraws from between the first ring 4 and the second ring 5, cutting off the diaphragm 6 and the adsorbed tumor tissue. The cut tumor tissue is sucked into the upper cylinder body 2 to complete the sampling. Unscrew the lower cylinder body 1, push the push-pull piece 22 in the reverse direction to move the piston upward, and push out the sample for testing.

[0040] Negative pressure control optimization: The outer wall of the lower cylinder body 1 is engraved with equally spaced scale marks longitudinally. The scale range is 0 - 50 mm, with a main scale every 5 mm, corresponding to the moving distance of the rubber piston 20. When the push-pull piece 22 at the end of the pull rod 21 drives the piston 20 to move downward, the operator can accurately control the position of the piston according to the scale marks. For example, when pulled to 20 mm, the negative pressure inside the cylinder is about -0.06 MPa, which is suitable for adsorbing relatively soft tumor tissues; when pulled to 40 mm, the negative pressure increases to -0.08 MPa, which is applicable to harder or deep tissues. The scale marks assist the operator in adjusting the adsorption force according to the characteristics of the target tissue, improving the sampling accuracy.

[0041] Only some exemplary embodiments of the present invention have been described by way of illustration above. Undoubtedly, for those of ordinary skill in the art, without departing from the spirit and scope of the present invention, the described embodiments can be modified in various different ways. Therefore, the above drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A rapid tumor sampling device, comprising a lower cylinder body (1) and an upper cylinder body (2), characterized in that: One side of the top of the upper cylinder body (2) is communicated with an adsorption tube (3) through an opening. The inner walls of the top of the adsorption tube (3) are respectively fixedly provided with a first ring (4) and a second ring (5). A diaphragm (6) is adhesively connected to the inner walls of the first ring (4) and the second ring (5) on the corresponding side. A cutting wire (19) is inserted into the gap between the first ring (4) and the second ring (5). The outer walls of both ends of the cutting wire (19) pass through one side of the top of the adsorption tube (3) and are fixedly connected to the outer wall of the top of the first slider (9). One side of the outer wall of the top of the upper cylinder body (2) is fixedly provided with an excitation tube (8). The inner walls of the excitation tube (8) are respectively slidably connected with a first slider (9) and a second slider (10). One end of the bottom of the first slider (9) is fixedly provided with a spring (11). The other end of the spring (11) is fixedly connected to the outer wall of the second slider (10).

2. The tumor rapid sampling device according to claim 1, characterized in that: A first positioning hole (12) is opened on one side of the outer wall of the first slider (9). A second positioning hole (13) is opened on one side of the outer wall of the excitation tube (8). A first pin (14) is inserted into the second positioning hole (13).

3. The tumor rapid sampling device according to claim 1, characterized in that: A vertically downward chute (18) is opened on one side of the outer wall of the excitation tube (8). A first fixing hole (15) penetrating through is opened on one side of the outer wall of the second slider (10). A second fixing hole (16) is opened on the inner wall of one side of the bottom of the excitation tube (8). A chute (18) of a matching size is inserted into the first fixing hole (15). The outer wall of the second pin (17) is slidably connected to the inner wall of the chute (18).

4. The tumor rapid sampling device according to claim 1, wherein: An external thread interface is opened on the outer wall of the top of the lower cylinder body (1). An internal thread interface is opened on the inner wall of the bottom of the upper cylinder body (2). The top of the lower cylinder body (1) is threadedly connected to the bottom of the upper cylinder body (2).

5. The rapid tumor sampling device according to claim 1, wherein: A strip-shaped guiding cover (7) is fixedly provided on one side of the outer wall of the top of the adsorption tube (3). Both ends of the cutting wire (19) are connected to the outer wall of the top of the first slider (9) through the strip-shaped guiding cover (7).

6. The rapid tumor sampling device according to claim 1, wherein: A rubber piston (20) is slidably connected to the inner walls of the lower cylinder body (1) and the upper cylinder body (2). A vertically downward pull rod (21) is fixedly provided on the outer wall of the bottom of the rubber piston (20). A push-pull piece (22) is fixedly provided at one end of the bottom of the pull rod (21).

7. The tumor rapid sampling device according to claim 1, wherein: The inner walls of the first ring (4) and the second ring (5) are respectively provided with guiding grooves. The cutting wire (19) is slidably arranged along the guiding grooves. The depth of the guiding grooves is adapted to the diameter of the cutting wire (19) to enhance the path stability of the cutting wire (19) during the extraction process.

8. The tumor rapid sampling device according to claim 1, wherein: Scale marks are provided on the outer wall of the lower cylinder body (1). The scale marks correspond to the moving position of the rubber piston (20) and are used to indicate the magnitude of the negative pressure in the cylinder to assist the operator in precisely controlling the adsorption force.

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