Ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor and application

Abstract

The invention discloses an ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor and application, and belongs to the technical field of terahertz metasurface biosensing. The ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor is composed of an ordered single-walled carbon nanotube metasurface layer and a dielectric substrate layer from top to bottom, the ordered single-walled carbon nanotube metasurface layer is an anisotropic ordered single-walled carbon nanotube film, the ordered single-walled carbon nanotube film comprises a plurality of unit structures which are periodically arranged, and each unit structure is provided with a laser-etched geometric symmetry pattern; a non-zero included angle is formed between the orientation of the ordered single-walled carbon nanotube metasurface layer and the geometric symmetry pattern; by utilizing the design of anisotropy and non-zero included angle of the ordered single-walled carbon nanotubes, the limitation that a CNT-based chiral metasurface sensor in the prior art excessively depends on chiral patterns is overcome, so that enhancement and sensing detection of chiral attributes of biomolecules are realized.

Description

Technical Field

[0001] The present invention relates to the technical field of terahertz metasurface biosensing, and particularly relates to an ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor and its application. Background Art

[0002] Chirality is a fundamental property in nature where a molecule is non-superimposable on its mirror image and is of core significance in life sciences. The chirality recognition ability of biomolecules (such as proteins, nucleic acids, carbohydrates, etc.) directly affects their biological functions. Therefore, in the fields of drug development, disease diagnosis, and biosensing, the precise detection and analysis of chiral molecules are of crucial importance. Circular dichroism (CD), as a core parameter for quantifying chiral phenomena, is defined as the normalized value of the absorption difference of a material for left-handed circularly polarized light (LCP) and right-handed circularly polarized light (RCP). The CD signals of natural biomolecules are usually extremely weak (CD value < 2) and are difficult to be directly applied. Although artificial chiral metamaterials (such as metal metasurfaces) can significantly enhance the CD response through structural design, their metal components are prone to non-specific adsorption with biomolecules, resulting in poor biocompatibility and may disrupt the natural conformation and activity of biomolecules, limiting their application in complex biological systems.

[0003] Carbon nanotube (CNT) materials provide an ideal platform for biosensing due to their chemical inertness, high specific surface area, and good biocompatibility. Their unique π-electron conjugated structure can preserve the natural functions of biomolecules, and the abundant surface adsorption sites can improve the sensing sensitivity. However, existing CNT-based chiral metasurface sensors rely on complex chiral pattern designs (such as helices, asymmetric holes, etc.) to achieve CD responses, and have the following key defects: they need to pre-construct asymmetric geometric structures, with complex preparation processes and difficult dynamic regulation; symmetric structures (such as periodic arrays, uniform thin films, etc.) lack intrinsic chiral sources and cannot generate effective CD signals, resulting in low device design freedom.

[0004] Therefore, how to provide an ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor that can break through the limitation of chiral response of symmetric structures while maintaining the biocompatibility advantages of CNTs has become a technical problem that needs to be urgently solved by those skilled in the art. Summary of the Invention

[0005] The purpose of the present invention is to provide an ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor and its application to overcome the problem that symmetric structures in the prior art cannot generate effective CD signals.

[0006] The present invention solves the above technical problems through the following technical solutions: An ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor is composed of an ordered single-walled carbon nanotube metasurface layer and a dielectric substrate layer from top to bottom; The ordered single-walled carbon nanotube metasurface layer is an anisotropic ordered single-walled carbon nanotube thin film, and the ordered single-walled carbon nanotube thin film includes several periodically arranged unit structures, and each unit structure is provided with a geometric symmetry pattern etched by laser; There is a non-zero angle between the orientation of the ordered single-walled carbon nanotube metasurface layer and the geometric symmetry pattern.

[0007] A further improvement of the present invention is that the ordered single-walled carbon nanotube metasurface layer is prepared by a grating imprinting filter membrane vacuum filtration method.

[0008] A further improvement of the present invention is that the ordered single-walled carbon nanotube thin film is a single-oriented single-walled carbon nanotube thin film.

[0009] A further improvement of the present invention is that the ordered single-walled carbon nanotube thin film is an ordered single-walled carbon nanotube thin film obtained by specifically modifying the carbonaceous by-products of the ordered single-walled carbon nanotube thin film, and the carbonaceous by-products are amorphous carbon or dispersant particles.

[0010] A further improvement of the present invention is that the thickness of the ordered single-walled carbon nanotube metasurface layer is 1 - 5 μm.

[0011] A further improvement of the present invention is that the geometric symmetry pattern is one of a cross, a circle or a square.

[0012] A further improvement of the present invention is that the material of the dielectric substrate layer is one of polycarbonate, polyethylene terephthalate and polydimethylsiloxane.

[0013] A further improvement of the present invention is that the period of the periodically arranged unit structures is 250 - 350 μm.

[0014] A further improvement of the present invention is that the thickness of the dielectric substrate layer is 7 - 30 um.

[0015] The present invention also provides an application of the ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor as described above in biological detection.

[0016] Compared with the prior art, the positive and progressive effects of the present invention are as follows: The ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor provided by the present invention is composed of an ordered single-walled carbon nanotube metasurface layer and a dielectric substrate layer from top to bottom; the ordered single-walled carbon nanotube metasurface layer is an anisotropic ordered single-walled carbon nanotube thin film, and the ordered single-walled carbon nanotube thin film includes several periodically arranged unit structures, and each unit structure is provided with a geometric symmetric pattern etched by laser; there is a non-zero angle between the orientation of the ordered single-walled carbon nanotube metasurface layer and the geometric symmetric pattern; the present invention utilizes the anisotropy of the ordered single-walled carbon nanotubes and the design of the non-zero angle to overcome the limitation that the existing CNT-based chiral metasurface sensor relies too much on the chiral pattern, thereby realizing the enhancement and sensing detection of the chiral property of the biomolecule itself.

[0017] Furthermore, the ordered single-walled carbon nanotube metasurface layer is prepared by using a grating imprint filtration vacuum filtration method for the anisotropic ordered single-walled carbon nanotube thin film. The grating imprint filtration vacuum filtration method can precisely control the arrangement mode of the single-walled carbon nanotubes, making the single-walled carbon nanotubes present a highly ordered state in the thin film, which not only enhances the anisotropic characteristics of the ordered single-walled carbon nanotubes, but also provides a stable and consistent chiral response basis for the sensor. Compared with the traditional chiral pattern preparation method, it avoids complex etching and processing steps and improves production efficiency.

[0018] Furthermore, the anisotropic single-orientation ordered single-walled carbon nanotube thin film has a high degree of orientation consistency, so that it can show a stronger chiral response when interacting with light, which is crucial for improving the sensitivity of the sensor and helps to more accurately detect and analyze chiral biomolecules. Description of the Drawings

[0019] The accompanying drawings in the specification are used to provide a further understanding of the present invention and constitute a part of the present invention. The schematic embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation to the present invention.

[0020] Figure 1 It is a scanning electron microscope result diagram of the ordered single-walled carbon nanotube metasurface layer of the present invention; Figure 2 It is a schematic diagram of an ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor of the present invention; Figure 3 It is a schematic diagram of the unit structure of an ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor of the present invention; Figure 4 It is the CD spectrum of an ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor of the present invention compared with an isotropic disordered traditional carbon nanotube thin film-based metasurface; Figure 5The polarization ellipse angle (PEA) spectrum of an ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor of the present invention when covering different volumes of D-lactic acid; Figure 6 The simulated polarization rotation angle (PRA) spectrum of an ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor of the present invention when covering different volumes of D-lactic acid; Figure 7 The simulated polarization ellipse diagram of an ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor of the present invention when covering different volumes of D-lactic acid; Among them, 1 is the dielectric substrate layer, and 2 is the ordered single-walled carbon nanotube metasurface layer. Detailed implementation manners

[0021] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are some, but not all, of the embodiments of the present invention. Usually, the components of the embodiments of the present invention described and shown in the accompanying drawings here can be arranged and designed in various different configurations.

[0022] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed present invention, but merely represents selected embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts fall within the scope of protection of the present invention.

[0023] It should be noted that: similar reference numerals and letters denote similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0024] The following further detailed description of the present invention with reference to the accompanying drawings and specific embodiments is an explanation of the present invention rather than a limitation.

[0025] See Figure 1 , an ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor, From top to bottom, it is composed of an ordered single-walled carbon nanotube metasurface layer 2 and a dielectric substrate layer 1; The ordered single-walled carbon nanotube metasurface layer 2 is an anisotropic ordered single-walled carbon nanotube thin film, and the ordered single-walled carbon nanotube thin film includes several periodically arranged unit structures, and each unit structure is provided with a geometric symmetric pattern etched by laser; The orientation of the ordered single-walled carbon nanotube metasurface layer 2 has a non-zero angle with the geometric symmetric pattern.

[0026] The ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor provided by the present invention is composed of an ordered single-walled carbon nanotube metasurface layer 2 and a dielectric substrate layer 1 from top to bottom; the ordered single-walled carbon nanotube metasurface layer 2 is an anisotropic ordered single-walled carbon nanotube thin film, and the ordered single-walled carbon nanotube thin film includes a number of periodically arranged unit structures, and each unit structure is provided with a geometric symmetric pattern etched by laser; there is a non-zero angle between the orientation of the ordered single-walled carbon nanotube metasurface layer 2 and the geometric symmetric pattern; the present invention utilizes the anisotropy of the ordered single-walled carbon nanotubes and the design of the non-zero angle to overcome the limitation that the existing CNT-based chiral metasurface sensor relies too much on the chiral pattern, thereby realizing the enhancement and sensing detection of the chiral property of the biomolecule itself.

[0027] Specifically, the ordered single-walled carbon nanotube metasurface layer 2 is prepared by a grating imprint filtration vacuum filtration method.

[0028] The ordered single-walled carbon nanotube metasurface layer 2 is prepared by a grating imprint filtration vacuum filtration method for an anisotropic ordered single-walled carbon nanotube thin film. The grating imprint filtration vacuum filtration method can precisely control the arrangement of single-walled carbon nanotubes, making the single-walled carbon nanotubes show a highly ordered state in the thin film, not only enhancing the anisotropic characteristics of the ordered single-walled carbon nanotubes, but also providing a stable and consistent chiral response basis for the sensor. Compared with the traditional chiral pattern preparation method, it avoids complex etching and processing steps and improves production efficiency.

[0029] Specifically, the ordered single-walled carbon nanotube thin film is a single-oriented single-walled carbon nanotube thin film.

[0030] The anisotropic single-oriented single-walled carbon nanotube thin film has a high degree of orientation consistency, so that it can show a stronger chiral response when interacting with light, which is crucial for improving the sensitivity of the sensor and helps to detect and analyze chiral biomolecules more accurately.

[0031] Specifically, the ordered single-walled carbon nanotube thin film is an ordered single-walled carbon nanotube thin film obtained by specifically modifying the carbonaceous by-products of the ordered single-walled carbon nanotube thin film, and the carbonaceous by-products are amorphous carbon or dispersant particles.

[0032] By specifically modifying the carbonaceous by-products on the surface of the ordered single-walled carbon nanotube film, the surface properties of the carbon nanotubes, such as hydrophilicity / hydrophobicity and charge state, can be further optimized. These modifications can enhance the interaction between the ordered single-walled carbon nanotube film and biomolecules, improve the sensing performance of the sensor, and endow it with higher recognition ability and affinity for specific biomolecules. The specifically modified ordered single-walled carbon nanotube film can be customized according to different application requirements, enabling the sensor to be applicable to the detection of more types of chiral biomolecules, broadening the application scope of the sensor, and making it have a wider application prospect in the fields of biomedicine, drug development, environmental monitoring, etc.

[0033] Specifically, the thickness of the ordered single-walled carbon nanotube super-surface layer 2 is 1 - 5 μm.

[0034] Specifically, the geometric symmetry pattern is one of a cross, a circle, or a square.

[0035] Specifically, the material of the dielectric base layer 1 is one of polycarbonate, polyethylene terephthalate, and polydimethylsiloxane.

[0036] Specifically, the period of the periodically arranged unit structure is 250 - 350 μm.

[0037] Specifically, the thickness of the dielectric base layer 1 is 7 - 30 μm.

[0038] Based on the same inventive concept, the present invention also provides an application of the ordered single-walled carbon nanotube chiral super-surface biomolecule polarization sensor as described above in biological detection.

[0039] Example 1: An ordered single-walled carbon nanotube metasurface layer 2 is prepared by a method of vacuum filtration through a grating imprinted filter membrane, which specifically includes the following steps: Before vacuum filtration, the filter membrane is placed on a heating plate at 165° for heating, and then the grooved surface of the grating is pressed on the filter membrane for three minutes; after three minutes, a 3 kg weight is placed above the grating and left standing for 17 minutes; after standing, the heating plate is turned off; after cooling for 20 minutes, the weight and the grating are removed and the imprinting direction of the grating grooves is marked; the filter membrane is placed in a filter flask and vacuum filtration is started for preparation. During the vacuum filtration process, the pressure is controlled so that the filtration rate is always kept below 12.5 milliliters per hour, and an anisotropic ordered single-walled carbon nanotube thin film with a thickness of 1 - 5 μm is obtained; a cross-shaped structure is etched on the ordered single-walled carbon nanotube thin film obtained by the method of vacuum filtration through a grating imprinted filter membrane by laser etching to obtain the ordered single-walled carbon nanotube metasurface layer 2. Specifically: the marked imprinting direction of the grating grooves is the direction of the ordered single-walled carbon nanotube thin film. During the laser etching of the cross, an angle of 45° is maintained between this direction and the cross-shaped structure, and finally an ordered single-walled carbon nanotube metasurface layer 2 with a periodically arranged unit structure and a period of 250 - 350 μm is obtained.

[0040] The single-walled carbon nanotube thin film used in the traditional single-walled carbon nanotube thin film metasurface does not have anisotropy. That is to say, no matter how the single-walled carbon nanotube thin film is placed during the cross-shaped etching process, there will be no angle with the cross-shaped structure. Therefore, the prepared single-walled carbon nanotube thin film metasurface does not have a chiral effect. In the prior art, it is necessary to laser etch an asymmetric pattern to make the traditional single-walled carbon nanotube thin film metasurface have a chiral effect; and often there will be large errors and extremely difficult processing during the laser processing of these asymmetric patterns, such as a spiral mosquito coil pattern.

[0041] The ordered single-walled carbon nanotube thin film metasurface adopted in the present invention itself has anisotropic conditions and can have an angle with symmetric figures such as a cross to generate a chiral effect, greatly avoiding the prerequisite that an asymmetric pattern must be etched to have a chiral response.

[0042] See Figure 2 and Figure 3 , an ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor, which consists of an ordered single-walled carbon nanotube metasurface layer 2 and a dielectric substrate layer 1 from top to bottom; the ordered single-walled carbon nanotube metasurface layer 2 is composed of periodically arranged unit structures, and each unit structure contains a geometric symmetric pattern etched by laser; the geometric symmetric pattern is a cross-shaped pattern; the orientation of the ordered single-walled carbon nanotube metasurface layer 2 has a non-zero angle with the geometric symmetric pattern. Specifically: See Figure 2Lower left corner coordinate system, the x-axis is the direction of the cross-shaped structure, and the dashed arrow is the orientation direction of the ordered single-walled carbon nanotube film; the direction of the ordered single-walled carbon nanotube film is oriented at a 45° angle with the cross-shaped structure along the x-axis. The periods of the unit structures are 、 , where : = 1, = = 295 , the line width w of the etched completely symmetric cross-shaped structure is 10 , and the horizontal and vertical lengths of the cross-shaped structure l are both 120 .

[0043] The periodic array structure designed and processed by using the ordered single-walled carbon nanotube film in the present invention can introduce a chiral effect for the metasurface by utilizing the excellent anisotropy of the ordered carbon nanotubes themselves when the metasurface pattern has perfect symmetry and does not have any chiral effects, which is a characteristic that the current carbon nanotube-based chiral metasurfaces do not have; by highly sensitive recognition of terahertz spectroscopy to distinguish trace biomolecules, especially for natural chiral biomolecular enantiomer molecules with almost the same physical and chemical properties, it can achieve the enhancement of the chiral properties of biomolecules themselves and sensing detection; compared with the traditional refractive index sensing method of the current carbon nanotube-based metasurface sensors, due to the almost identical real parts of the refractive indices of chiral enantiomers, it is almost difficult to distinguish enantiomers by the traditional method; while the polarization sensing used in the present invention can avoid the influence brought by the real part of the refractive index to the greatest extent, and the sensing effect is determined by the imaginary part of the refractive index of the analyte, and it can qualitatively and quantitatively sense and detect chiral enantiomers; at the same time, due to the good modifiability and high biocompatibility of carbon nanotubes themselves, the ordered carbon nanotube film metasurface used in the present invention is prepared by a simple process, effectively solving the difficulties such as large ohmic loss and easy corrosion of traditional metal metasurfaces and changes in sensor characteristics under deformation conditions, so that the detection accuracy, designability and sensitivity of the device are all improved.

[0044] See Figure 4, the black dashed line represents the Disordered SWCNTs film, referring to the traditional single-walled carbon nanotube film metasurface with a cross-shaped structure, whose CD value is 0 at 0.1 - 1 THz; the black solid line represents the Ordered SWCNTs film, referring to the ordered single-walled carbon nanotube metasurface layer 2 of the present invention. Under the same cross-shaped structure, its CD has non-zero values, and reaches a maximum of 0.3° at 0.7 THz. Through analysis, it can be seen that when the metasurface material with a cross-shaped structure is a traditional single-walled carbon nanotube film, it does not exhibit chiral characteristics. However, there is a non-zero angle between the orientation of the ordered single-walled carbon nanotube metasurface layer 2 of the present invention and the geometric symmetry pattern. When using a cross-shaped metasurface composed of an anisotropic ordered carbon nanotube film, good chiral characteristics are exhibited.

[0045] The polarization property generated by the ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor is generated by the anisotropy of the introduced ordered single-walled carbon nanotube metasurface layer 2. The strength of the polarization property is affected by the designed unit structure. The magnitudes of the polarization ellipse angle PEA and the polarization rotation angle PRA and the variation frequency range are jointly determined by the quality of the orientation of the ordered single-walled carbon nanotube metasurface layer 2 and the geometric symmetry pattern of the periodically arranged unit structure.

[0046] See Figure 5 , PEA is expressed as the arctangent value of the minor axis to the major axis of the polarization ellipse. As shown in the figure, different volumes of the analyte D-lactic acid from 0 - 10 are covered on the ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor. In the range of 0.55 - 0.65 THz, PEA fluctuates greatly with the change in the volume of the analyte. While at other frequency bands, the value of PEA is close to 45°, that is, the polarization ellipse is approximately circular. Thus, different volumes of the analyte D-lactic acid cause a huge change in the polarization state of the linearly polarized incident terahertz wave in the range of 0.55 - 0.65 THz under the chiral metasurface designed in the present invention. According to the change in the polarization state, the change in the concentration of D-lactic acid can be quantitatively detected.

[0047] See Figure 6 , PRA is expressed as the angle between the major axis of the polarization ellipse and the incident polarization direction. As shown in the figure, different volumes of the analyte D-lactic acid from 0 - 10 D-lactic acid of different volumes to be measured. In the range of 0.55 - 0.65 THz, the PRA fluctuates greatly with the change of the volume of the analyte; while at 0.55 THz and 0.65 THz, the values of PRA are both close to 90°, that is, the major axis of the polarization ellipse is approximately perpendicular to the polarization direction of the incident linearly polarized wave. Thus, D-lactic acid of different volumes to be measured causes a huge change in the polarization direction of the linearly polarized terahertz wave in the range of 0.55 - 0.65 THz under the chiral metasurface designed in the present invention. According to the change of the polarization direction, the change of the D-lactic acid concentration can be quantitatively detected.

[0048] See Figure 7 , the double-arrow solid line represents the polarization state of the incident terahertz wave, and the remaining ellipses are 0 - 10 Polarization ellipse diagram of the terahertz wave emitted by D-lactic acid of different volumes to be measured at 0.61 THz. Specifically, with the change of the volume of the analyte, the polarization ellipse of the emitted wave rotates counterclockwise. Thus, under the action of the present invention, it is possible to well distinguish the change of the polarization state of the terahertz wave caused by D-lactic acid of different volumes.

[0049] Different from the traditional carbon nanotube-based sensing method, the present invention amplifies the optical activity of the chiral substance itself through the designed ordered single-walled carbon nanotube metasurface layer 2, and realizes the quantitative detection of chiral substances by using the difference in the polarization direction of the emitted light in the detection of chiral molecules; the ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor can realize the quantitative sensing of chiral biomolecules of different volumes under the coverage of chiral molecules.

[0050] Finally, it should be noted that: the above-listed embodiments exist only as one or more specific forms of the technical solution of the present invention. Their purpose is to clearly elaborate the concept, principle and application method of the present invention through specific examples, rather than intending to limit the protection scope of the present invention to these specific embodiments. In fact, the true value of the present invention lies in the proposed technical idea and innovation point, rather than its form of expression or implementation means.

[0051] For those of ordinary skill in the art, after deeply reading and understanding the technical solution of the present invention, they are fully capable of making various forms of changes, modifications or equivalent replacements to the specific implementation manner of the invention based on their own professional knowledge and skills. These changes may include, but are not limited to: adjusting the value range of technical parameters, optimizing the algorithm process to improve efficiency, replacing some technical components to achieve better compatibility or reduce costs, etc. As long as the changed technical solution still substantially maintains the technical features required to be protected by the original invention, that is, it can still achieve the core functions and effects of the present invention, then these changes should be regarded as falling within the protection scope of the pending claims of the present invention.

[0052] In addition, with the continuous progress and development of technology, new technical means and methods are constantly emerging, which also provides broad space for the further improvement and perfection of the present invention. Therefore, the protection scope of the present invention should also include those reasonable and foreseeable improvements and expansions based on the prior art. As long as these improvements and expansions do not depart from the basic principles and core concepts of the present invention, they should be regarded as equivalents of the present invention and are equally protected by the patent right.

Claims

1. An ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor, characterized in that, It is composed of an ordered single-walled carbon nanotube metasurface layer (2) and a dielectric substrate layer (1) from top to bottom; The ordered single-walled carbon nanotube metasurface layer (2) is an anisotropic ordered single-walled carbon nanotube thin film, and the ordered single-walled carbon nanotube thin film includes a number of periodically arranged unit structures, and each unit structure is provided with a geometric symmetric pattern etched by laser; There is a non-zero angle between the orientation of the ordered single-walled carbon nanotube metasurface layer (2) and the geometric symmetric pattern.

2. The ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor according to claim 1, characterized in that The ordered single-walled carbon nanotube metasurface layer (2) is prepared by a grating imprint filter membrane vacuum filtration method.

3. An ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor according to claim 1, characterized in that, The ordered single-walled carbon nanotube thin film is a single-oriented single-walled carbon nanotube thin film.

4. The chiral metasurface biomolecule polarization sensor made of ordered single-walled carbon nanotubes according to claim 1, wherein The ordered single-walled carbon nanotube thin film is an ordered single-walled carbon nanotube thin film obtained by specifically modifying the carbonaceous by-products of the ordered single-walled carbon nanotube thin film, and the carbonaceous by-products are amorphous carbon or dispersant particles.

5. The chiral metasurface biomolecule polarization sensor based on ordered single-walled carbon nanotubes according to claim 1, wherein The thickness of the ordered single-walled carbon nanotube metasurface layer (2) is 1-5 μm.

6. The chiral metasurface biomolecule polarization sensor based on ordered single-walled carbon nanotubes according to claim 1, characterized in that, The geometric symmetric pattern is one of a cross, a circle or a square.

7. The chiral metasurface biomolecule polarization sensor based on ordered single-walled carbon nanotubes according to claim 1, characterized in that The material of the dielectric substrate layer (1) is one of polycarbonate, polyethylene terephthalate and polydimethylsiloxane.

8. An ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor according to claim 1, characterized in that, The period of the periodically arranged unit structures is 250-350 μm.

9. The ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor according to claim 1, characterized in that, The thickness of the dielectric substrate layer (1) is 7-30 um.

10. Application of an ordered single-walled carbon nanotube chiral metasurface biomolecule polarization sensor as described in any one of claims 1-9 in biological detection.

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