Radix morindae officinalis polysaccharide-synanthrin composite gel as well as preparation method and application thereof

Through the multi-target effect of Morinacea polysaccharide-inulin complex gel, the problems of intestinal homeostasis reconstruction and drug transport in the treatment of renal fibrosis were solved, effective interventions in intestinal barrier repair and renal fibrosis were achieved, and safe and efficient treatment plans were provided.

CN120459131AActive Publication Date: 2025-08-12GUANGDONG PHARMA UNIV
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Patent Information

Application Number
CN202510971824.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-15
Publication Date
2025-08-12
Estimated Expiration
2045-07-15

AI Technical Summary

Technical Problem

Existing therapeutic strategies are difficult to achieve effective intervention in renal fibrosis, especially in terms of challenges in intestinal homeostasis reconstruction and long-term remission, and the transport process of drugs in the gastrointestinal tract faces complex environmental impacts, affecting drug stability and absorption effect.

Method used

It provides a Morinacea polysaccharide-inulin complex gel composed of Morinacea polysaccharide, inulin and water. It achieves multi-target effects through a composite design, which can regulate immune response and intestinal microbiota, interfere with intestinal barriers and renal fibrosis.

Benefits of technology

This composite gel has good biocompatibility and safety, and can intervene at the same time against intestinal microenvironment and renal fibrosis, significantly improve the therapeutic effect, provide new treatment options, and fill the gap in existing treatment methods.

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Abstract

The invention belongs to the technical field of biological medicine, and particularly relates to morinda officinalis polysaccharide-synanthrin composite gel as well as a preparation method and application thereof. The radix morindae officinalis polysaccharide-synanthrin composite gel provided by the invention is prepared from radix morindae officinalis polysaccharide, synanthrin and water. The radix morindae officinalis polysaccharide-synanthrin composite gel has good biocompatibility and multifunctionality, can intervene in the intestinal microenvironment and renal fibrosis at the same time, and fills the blank of existing treatment methods. The polypeptide has potential curative effects in the aspects of intestinal barrier repair, inflammation regulation and control, microorganism regulation and renal fibrosis inhibition, and a new treatment choice is provided for clinic. The raw materials of the composite gel are based on natural polysaccharides, have good safety and degradability, and meet the high requirements of the medical field on the safety of biological materials. Compared with the existing single-component hydrogel, the composite design of the hydrogel can realize a multi-target effect, the treatment effect is remarkably improved, and the hydrogel has a relatively great market competitive advantage.
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