Method for efficiently removing dimeticone / simethicone by using polyoxyethylene ether hydrogenated castor oil, preparation and application

Abstract

The invention discloses a method for efficiently removing dimeticone / simethicone by using polyoxyethylene ether hydrogenated castor oil, a preparation and application, the polyoxyethylene ether hydrogenated castor oil is used as a main effective component, and dimeticone and simethicone attached to a matrix are efficiently removed in a normal-temperature neutral environment. The polyoxyethylene ether hydrogenated castor oil is used for removing dimeticone and simethicone, the problem of cleaning of medical endoscopes at present is solved, the polyoxyethylene ether hydrogenated castor oil is used for removing simethicone on the medical endoscopes for the first time, and the cleaning agent has the advantages of being easy to operate, non-toxic, free of pollution, efficient, safe and the like and has great market application prospects.

Description

Technical Field

[0001] The present invention relates to the field of cleaning technology, and in particular to a method, preparation and application of efficiently removing dimethicone / simethicone by utilizing polyoxyethylene ether hydrogenated castor oil. Background Art

[0002] Dimethicone (polydimethylsiloxane), depending on the relative molecular mass, has an appearance ranging from a colorless, transparent volatile liquid to an extremely high viscosity liquid or silica gel. It is non-toxic, odorless, highly transparent, and has the characteristics of heat resistance, cold resistance, water resistance, low surface tension, stable viscosity, physiological inertness, and chemical stability. It can be mixed arbitrarily in chloroform, ether, toluene or xylene, and is insoluble in water or ethanol. Dimethicone is insensitive to common reagents such as acids, alkalis, and oxidants. Ordinary detergents are difficult to destroy its structure. It is easy to adhere to hydrophobic surfaces, and conventional water-based cleaning effects are poor. In precision instruments, electronic components or medical equipment, trace residues may affect performance. If it enters the environment, special treatment is required to avoid contamination. Dimethicone is difficult to remove, and industrial scenarios require chemical solvents or plasma technology for removal.

[0003] Simethicone, a mixture of liquid dimethicone (polydimethylsiloxane) and silicon dioxide, is chemically known as α-(trimethylsilyl)-ω-methylpoly[oxy(dimethylsilylene)] and silicon dioxide complex. It is a grayish-white to milky-white viscous liquid chemical that is virtually insoluble in water and methanol, but partially miscible with dichloromethane, ethyl acetate, butanone, and toluene. Simethicone is a gastrointestinal medication primarily used clinically to treat symptoms such as abdominal distension caused by excessive gas accumulation in the gastrointestinal tract. It can also be used as an adjunct to abdominal imaging examinations (e.g., X-rays, ultrasound, and gastroscopy) and as an additive to contrast agent suspensions for double-contrast imaging. Clinical use has shown that simethicone can significantly remove foam from the intestinal cavity, improve the clarity of the colonoscopy, and facilitate endoscopists' operations and the detection of lesions. Since dimethicone itself has strong adhesion, and the endoscope has a complex structure and is composed of a variety of materials, including metal, glass, and plastic with hydrophobic surfaces, it is difficult to remove dimethicone from the endoscope with general cleaning agents and cleaning processes. Simethicone that is not removed cleanly makes the endoscope lens blurred, affecting the clarity of the field of vision. At the same time, the attached simethicone can easily carry various pathogens, leading to cross-infection. Summary of the Invention

[0004] The object of the present invention is to address the above-mentioned problems and provide a method, preparation and application for efficiently removing dimethicone / simethicone using polyoxyethylene ether hydrogenated castor oil, so as to overcome the shortcomings of the prior art.

[0005] The technical solution adopted by the present invention is as follows: a method for efficiently removing dimethicone / simethicone using polyoxyethylene ether hydrogenated castor oil, using polyoxyethylene ether hydrogenated castor oil as the main active ingredient, and efficiently removing dimethicone or simethicone attached to a substrate under a neutral environment at room temperature, wherein efficient removal means that the substrate attached with dimethicone or simethicone is immersed in a solution containing polyoxyethylene ether hydrogenated castor oil for 5 minutes, and the removal rate of dimethicone or simethicone is greater than 90%.

[0006] Furthermore, the mass concentration of the polyoxyethylene ether hydrogenated castor oil is not less than 0.1%, where % represents the total mass percentage of the solution containing the polyoxyethylene ether hydrogenated castor oil.

[0007] Furthermore, the mass concentration of polyoxyethylene ether hydrogenated castor oil is 0.1%-10.0%, for example, it can be 0.1%, 0.15%, 0.2%, 0.5%, 0.8%, 1.0%, 2.0%, 3.0%, 5.0%, 5.5%, 6.0%, 6.5%, 7.0%, 8.0%, 10.0%, etc.

[0008] Furthermore, the neutral environment means that the pH value of the solution containing polyoxyethylene ether hydrogenated castor oil is 6.5-8.0, for example, the pH value can be 6.5, 7.0, 7.3, 7.5, 7.8, 8.0, etc.

[0009] Furthermore, the present invention also includes a preparation capable of efficiently removing dimethicone / simethicone, wherein the active ingredient of the preparation is polyoxyethylene ether hydrogenated castor oil, and the mass concentration of the polyoxyethylene ether hydrogenated castor oil is not less than 0.1%, where % represents the total mass percentage of the non-toxic preparation. The non-toxic preparation is preferably a liquid preparation, but can also be a gel preparation. In the case of a gel preparation, the dimethicone or simethicone is removed from the surface of the substrate by coating.

[0010] Furthermore, the pH value of the preparation is 6.5-8.0, and the pH value can be 6.5, 7.0, 7.3, 7.5, 7.8, 8.0, etc. The pH value can be adjusted using a commonly used pH regulator.

[0011] Furthermore, the mass concentration of the polyoxyethylene ether hydrogenated castor oil is 0.1%-10.0%, for example, it can be 0.1%, 0.15%, 0.2%, 0.5%, 0.8%, 1.0%, 2.0%, 3.0%, 5.0%, 5.5%, 6.0%, 6.5%, 7.0%, 8.0%, 10.0%, etc.

[0012] Furthermore, the preparation further contains a carrier and / or an acceptable excipient, wherein the carrier is another solvent compatible with polyoxyethylene ether hydrogenated castor oil, and the solvent may be water, propylene glycol, glycerol, polyethylene glycol, etc. The excipient is a synergist and / or a thickener compatible with polyoxyethylene ether hydrogenated castor oil.

[0013] The present invention further includes the use of the above-mentioned preparation for cleaning instruments, including industrial instruments (e.g., precision instruments, electronic components) and medical instruments (e.g., endoscope lenses), to remove dimethicone or simethicone from the instruments. When the above-mentioned preparation is a liquid, the instruments are immersed in the preparation for preferably at least 5 minutes.

[0014] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0015] 1. The inventors have discovered through experiments that, at a certain concentration, polyoxyethylene ether hydrogenated castor oil can efficiently remove dimethicone and simethicone under neutral conditions at room temperature. Specifically, the inventors have found that dimethicone and simethicone can be efficiently removed by immersing the substrate in a solution (containing polyoxyethylene ether hydrogenated castor oil) at room temperature and near-neutral pH for 5 minutes. The solution is non-toxic, non-irritating, and stable in nature. Compared with professional silicone oil cleaners and strong alkaline silicone oil cleaners, it is safer and more efficient in removing silicone oil, and is expected to replace the above products;

[0016] 2. The present invention uses polyoxyethylene hydrogenated castor oil to remove dimethicone and simethicone, which solves the current problem of removing simethicone from medical endoscopes. It is the first time that polyoxyethylene hydrogenated castor oil is used to remove simethicone from medical endoscopes. Studies have shown that polyoxyethylene hydrogenated castor oil is a relatively safe, mild, non-toxic, and side-effect-free substance for the human body and the environment, and does not cause harm to the substrate or the operator. This makes the application of the present invention safer and more reliable. Moreover, the present invention can be used not only to remove simethicone from medical endoscopes, but also to remove dimethicone in the daily chemical and chemical industries, and has great market application prospects. DETAILED DESCRIPTION

[0017] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0018] For those skilled in the art, polyoxyethylene ether hydrogenated castor oil is widely used in the fields of medicine and daily chemicals, and is often used as an emulsifier, solubilizer, and emollient. However, the present invention applies it to the removal of dimethicone and simethicone.

[0019] In order to verify the innovative achievements of the present invention, the following verification experiments are used to illustrate the invention.

[0020] 1. Silicone oil removal test 1

[0021] 1. Main materials

[0022] ①Dimethicone;

[0023] ② According to Table 1, prepare 0.1%, 0.5%, 1.0%, 5.0%, and 10.0% aqueous solutions as the samples to be tested;

[0024] Table 1 Cleaning materials

[0025]

[0026]

[0027] ③100mL beaker and glass slide.

[0028] 2. Test methods

[0029] ① Drop a drop of about 0.03 grams of dimethyl silicone oil on the slide and evenly apply it to 1 / 3 of the slide;

[0030] ② Place the slide coated with dimethicone oil in a beaker containing preparations of different formulas, in a solution at room temperature (20°C) and pH = 6.5-7.5, and soak it for different periods of time before taking it out for observation.

[0031] ③Evaluation criteria

[0032] + (dirty): There are large areas of blocky residues; - (clean): It is basically removed, with only a few dot-like residues on the slide; ± (a little residue): There is a small amount of residue, and the area is less than 1 / 4 of the original.

[0033] 3. Test results

[0034] See Table 2.

[0035] Table 2 Removal results of dimethicone

[0036]

[0037]

[0038]

[0039]

[0040] Note: + (not clean); - (clean); ± (a little residue).

[0041] 4. Test conclusion

[0042] ① The two zwitterionic surfactants (OA12 / 14, BS-12), two cationic surfactants (PHMB, BZK, DDAC), and two organic solvents (DSMO, ACN) listed in Table 2 were completely unable to remove dimethicone from the glass slides;

[0043] ② The three anionic surfactants listed in Table 2 (SMG, SDS, and ALES) have only a very weak effect in removing silicone oil and can basically be regarded as unable to remove dimethicone from the slide;

[0044] ③ Among the seven nonionic surfactants listed in Table 2 (APG-10, AEO-9, TW-80, F127, RH60, RH40, and PMP), only RH60, RH40, and AEO-9 can effectively remove dimethicone. Among them, polyoxyethylene ether hydrogenated castor oil (RH60 and RH40) can effectively remove dimethicone when the content is not less than 0.5% and the immersion time is not less than 5 minutes.

[0045] ④ Silicone oil cleaning agent A can effectively remove dimethyl silicone oil. When the content is not less than 1.0%, the immersion time is not less than 5 minutes, and dimethyl silicone oil can be removed efficiently.

[0046] ⑤ When dimethicone was replaced with simethicone, the experimental results were basically consistent with those of dimethicone. It was also found that the difficulty of removing simethicone was lower than that of removing dimethicone. Simethicone was easier to remove than dimethicone. This was because simethicone was a mixture of dimethicone and silicon dioxide, and simethicone contained only a small amount of dimethicone.

[0047] 2. Silicone oil removal test 2

[0048] 1. Main materials

[0049] ①Dimethicone;

[0050] ② According to the experimental results of "Silicone Oil Removal Test 1", RH60, RH40, silicone oil cleaning agent A, SDS, and AEO-9 were selected to prepare a 1% aqueous solution as the test sample; blank (pure water).

[0051] 2. Test methods

[0052] ①Weigh the slides separately first;

[0053] ② Drop a drop of about 0.03 grams of dimethicone on the slide and evenly apply it to 1 / 3 of the slide. Then weigh the total weight of the slide coated with dimethicone;

[0054] ③ Place the slide coated with dimethicone in a beaker containing different formulations of the preparations, and soak it in a solution at room temperature (20°C) for 5 minutes. Then take it out and soak it in pure water (do not shake it) to remove the preparation to be tested on the surface and take it out immediately. After it is naturally dried, weigh the slide again.

[0055] ④Evaluation criteria

[0056] The silicone oil removal rate was calculated according to the formula = [1-(weight after silicone oil removal-slide weight) ÷ (weight after silicone oil coating-slide weight)] × 100%.

[0057] 3. Test results

[0058] See Table 3.

[0059] Table 3 Removal rate of dimethyl silicone oil

[0060] 4. Test conclusion ① The removal rates of 1% polyoxyethylene ether (60) hydrogenated castor oil, polyoxyethylene ether (40) hydrogenated castor oil and silicone oil cleaning agent A for dimethicone oil were all greater than 90%.

[0061] ② The removal rate of dimethicone by 1% polyoxyethylene ether (60) hydrogenated castor oil is about 98.3%; the removal rates of dimethicone by 1% polyoxyethylene ether (40) hydrogenated castor oil and silicone oil cleaning agent A are about 95.8% and 96.0% respectively, and the two have comparable effects.

[0062] Example 1

[0063] The product is a liquid preparation, prepared with the following raw materials in percentage by weight: polyoxyethylene ether (40), hydrogenated castor oil (0.5%), and deionized water as the balance.

[0064] Preparation: ① Take the above raw materials according to the mass ratio and put them into deionized water; ② Stir them thoroughly and fill them into suitable containers using a filling machine to obtain the finished product.

[0065] Furthermore, the liquid preparation of this embodiment is added with the following excipients by mass percentage to obtain a commercial product:

[0066] Sodium bicarbonate: 0.001-0.01%;

[0067] Hydroxypropyl methylcellulose: 0.5-3.0%.

[0068] The cleaning ability of the commercial product was verified according to the above test method. The test results were consistent with the (RH40) 0.5% results in Table 2.

[0069] Example 2

[0070] The product is a gel preparation, which is prepared with the following raw materials in percentage by weight: polyoxyethylene ether (60) hydrogenated castor oil 1.0%, hydroxypropyl methylcellulose: 1.0%, and deionized water as the balance.

[0071] Preparation: ① Take the above raw materials according to the mass ratio, first add hydroxypropyl methylcellulose to an appropriate amount of warm water at about 70°C, fully swell it, and obtain colloid A; ② Then add the remaining raw materials to the remaining water, fully dissolve them, and mix them with solution A and stir evenly; ③ Use a filling machine to pack them into suitable containers to obtain the finished product.

[0072] The cleaning ability of the finished product was verified according to the above test method. After testing, the test results were consistent with the RH60 (1.0%) results in Table 2.

[0073] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A method for efficiently removing dimethicone / simethicone by using polyoxyethylene ether hydrogenated castor oil, characterized in that: With polyoxyethylene ether hydrogenated castor oil as the main active ingredient, the dimethicone or simethicone attached to the substrate can be efficiently removed under a neutral environment at room temperature. The efficient removal means that the substrate with dimethicone or simethicone attached is immersed in a solution containing polyoxyethylene ether hydrogenated castor oil for 5 minutes, and the removal rate of dimethicone or simethicone is greater than 90%.

2. The method according to claim 1, wherein The mass concentration of polyoxyethylene ether hydrogenated castor oil is not less than 0.1%, and % represents the total mass percentage of the solution containing polyoxyethylene ether hydrogenated castor oil.

3. The method according to claim 1, wherein The mass concentration of polyoxyethylene ether hydrogenated castor oil is 0.1%-10.0%.

4. The method according to claim 1, wherein Neutral environment means that the pH value of the solution containing polyoxyethylene ether hydrogenated castor oil is 6.5-8.

0.

5. The method according to claim 1, wherein The dimethicone is polydimethylsiloxane or simethicone is a mixture of polydimethylsiloxane and silicon dioxide.

6. A preparation capable of efficiently removing dimethicone / simethicone, characterized in that: The active ingredient of the preparation is polyoxyethylene ether hydrogenated castor oil, the mass concentration of polyoxyethylene ether hydrogenated castor oil is not less than 0.1%, and % represents the total mass percentage of the preparation.

7. The preparation according to claim 6, wherein The pH of the formulation is 6.5-8.

0.

8. The preparation according to claim 6, wherein The mass concentration of the polyoxyethylene ether hydrogenated castor oil is 0.1%-10.0%.

9. The preparation according to claim 6, wherein The preparation further contains a carrier and / or an acceptable auxiliary material, wherein the carrier is other solvents compatible with polyoxyethylene ether hydrogenated castor oil; and the auxiliary material is a synergist and / or a thickener compatible with polyoxyethylene ether hydrogenated castor oil.

10. Use of the preparation according to claim 6 in cleaning instruments, characterized in that: The instruments include industrial instruments and medical instruments, and the dimethicone or simethicone on the instruments is cleaned and removed by the preparation.

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