Animal in-vitro tissue sampling device

Abstract

The invention relates to the technical field of animal in-vitro experiment equipment, in particular to an animal in-vitro tissue sampling device. The animal in-vitro tissue sampling device comprises a sampling needle, a frame, a sample carrier, a storage unit and a movable unit, the sample carrier is connected to the frame and is used for placing animal in-vitro tissues; the storage unit is connected to the frame and is used for storing sampling needles and samples; the movable unit is movably connected to the frame and is detachably connected with the sampling needle; wherein the movable unit is used for being connected with a sampling needle at the storage unit and moving the sampling needle to the sample carrier for sample collection; and transferring the collected sample to a storage unit for storage. The animal in-vitro tissue sampling device can improve the efficiency and reduce the labor cost.

Description

Technical Field

[0001] The present invention relates to the technical field of animal in vitro experimental equipment, in particular to an animal in vitro tissue sampling device. Background Art

[0002] In vitro animal experiments refer to experimental studies conducted under in vitro conditions after removing animal tissues, organs, or cells from the organism. Although these tissues, organs, or cells have been removed from the organism, they still maintain certain physiological functions and structural integrity, and can simulate physiological or pathological processes in the body to a certain extent.

[0003] However, the existing technology is to manually sample animal tissues, organs or cells for experiments, which has the problems of high labor costs and low efficiency. Summary of the Invention

[0004] The purpose of the present invention includes providing an animal ex vivo tissue sampling device, which can improve efficiency and reduce labor costs.

[0005] The embodiments of the present invention can be implemented as follows:

[0006] The present invention provides an animal in vitro tissue sampling device, comprising:

[0007] Sampling needle;

[0008] frame;

[0009] A sample carrier, connected to the frame and used for placing animal ex vivo tissue;

[0010] A storage unit connected to the frame and used to store sampling needles and samples;

[0011] A movable unit, the movable unit is movably connected to the frame and detachably connected to the sampling needle;

[0012] The movable unit is used to connect the sampling needle to the storage unit and move to the sample carrier to collect samples; and transfer the collected samples to the storage unit for storage.

[0013] In an optional embodiment, the movable unit includes a first movable assembly, a second movable assembly, and a third movable assembly that are movably connected, and an end of the first movable assembly close to the sample carrier is detachably connected to the sampling needle;

[0014] The first moving assembly is used to drive the sampling needle to move along the first direction, the second moving assembly is used to drive the sampling needle to move along the second direction, and the third moving assembly is used to drive the sampling needle to move along the third direction;

[0015] The first direction, the second direction and the third direction are perpendicular to each other.

[0016] In an optional embodiment, the first moving assembly includes a chuck and a first driver, the first driver being connected to the chuck to actuate the chuck to move along a first direction, and the chuck has at least a first position and a second position;

[0017] When the chuck is in the first position, the chuck is closed; when the chuck is in the second position, the chuck is open.

[0018] In an optional embodiment, the first moving assembly further comprises a piston provided with a protrusion; the sampling needle comprises a body and a push rod, the body being sleeved on the push rod; the piston is connected to the body;

[0019] When the chuck is located at the first position, the chuck clamps the push rod; when the chuck is located at the second position, the chuck abuts against the protrusion.

[0020] In an optional embodiment, the first moving assembly further includes a sleeve, which is sleeved on the chuck; the sleeve is connected to the first driver, and the first driver actuates the sleeve to move along the first direction to abut against the body.

[0021] In an optional embodiment, the second moving assembly includes a second driver, a first slider, and a first guide rail, the second driver being connected to the first slider and configured to actuate the first slider to move along the second direction; the first slider being slidably engaged with the first guide rail; and the extension direction of the first guide rail being parallel to the second direction;

[0022] The third moving assembly includes a third driver, a second slider, and a second guide rail. The third driver is connected to the second slider and is used to actuate the second slider to move along the third direction. The second slider is slidably engaged with the second guide rail, and the extension direction of the second guide rail is parallel to the third direction.

[0023] The first slider is connected to the first moving component and the second slider.

[0024] In an optional embodiment, the movable unit includes a wire feeder and a plastic wire, and the wire feeder is movably connected to the plastic wire; the plastic wire is sleeved on the sampling needle.

[0025] In an optional embodiment, the storage unit includes a first sampling needle storage part, a second sampling needle storage part, a sample storage part, and a connecting plate; the first sampling needle storage part, the second sampling needle storage part, and the sample storage part are all connected to the connecting plate; the connecting plate is connected to the frame;

[0026] The first sampling needle storage part is used to store the sampling needle before sampling, and the second sampling needle storage part is used to store the sampling needle after sampling.

[0027] In an optional embodiment, the first sampling needle storage member is provided with a plurality of first accommodating holes, and the second sampling needle storage member is provided with a plurality of second accommodating holes; each first accommodating hole corresponds to a second accommodating hole;

[0028] The sample storage member is provided with a plurality of sample accommodating holes, and each sample accommodating hole corresponds to a second accommodating hole.

[0029] In an optional embodiment, the sample carrier is provided with a plurality of sampling holes, each sampling hole corresponding to a sample containing hole.

[0030] The beneficial effects of the animal ex vivo tissue sampling device provided by the embodiment of the present invention include:

[0031] The animal ex vivo tissue sampling device includes a sampling needle, a frame, a sample carrier, a storage unit and a movable unit; the sample carrier is connected to the frame and is used to place the animal ex vivo tissue; the storage unit is connected to the frame and is used to store the sampling needle and the sample; the movable unit is movably connected to the frame and is detachably connected to the sampling needle; wherein the movable unit is used to connect the sampling needle to the storage unit and move it to the sample carrier for sample collection; and transfer the collected sample to the storage unit for storage.

[0032] Before sampling, the sampling needle is located in the storage unit. The active unit connects to the sampling needle and moves it to the sample carrier, allowing it to sample the animal's ex vivo tissue placed on the sample carrier. After sampling is completed, the active unit moves the sampling needle back to the storage unit to deposit the sample there. The active unit then removes the sampling needle and stores it in the storage unit.

[0033] Therefore, this embodiment can realize the automated sampling of animal ex vivo tissues, and can store samples and sampling needles, thereby reducing labor costs while improving sampling efficiency, and can also avoid contamination of collected samples, thereby improving the accuracy of the experiment. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying any creative work.

[0035] Figure 1 A schematic diagram of the structure of the animal ex vivo tissue sampling device provided in this embodiment;

[0036] Figure 2 A schematic structural diagram of the first moving member provided in this embodiment from a first viewing angle;

[0037] Figure 3 A schematic structural diagram of the second moving member and the third moving member provided in this embodiment;

[0038] Figure 4 A schematic diagram of the partial structure of the first moving member provided in this embodiment from a second viewing angle;

[0039] Figure 5 for Figure 4 A partial enlarged view of point A in the middle;

[0040] Figure 6 A schematic cross-sectional view of the sampling needle provided in this embodiment in the sampling state;

[0041] Figure 7 A schematic cross-sectional view of the sampling needle in the withdrawn state provided in this embodiment;

[0042] Figure 8 A schematic structural diagram of a wire feeder provided in other embodiments;

[0043] Figure 9 A schematic structural diagram of the storage unit provided in this embodiment;

[0044] Figure 10 Schematic diagram of the structure of the sample carrier provided.

[0045] Icon: 100-animal ex vivo tissue sampling device; 110-sampling needle; 111-body; 112-push rod; 120-frame; 130-sample carrier; 131-sampling hole; 140-storage unit; 141-first sampling needle storage member; 1411-first accommodating hole; 142-second sampling needle storage member; 1421-second accommodating hole; 143-sample storage member; 1431-sample accommodating hole; 144-connecting plate; 150-movable unit; 151-first moving component; 1 511-chuck; 1512-first drive; 1513-piston; 1514-protrusion; 1515-sleeve; 1516-motor; 152-second moving assembly; 1521-second drive; 1522-first slider; 1523-first guide rail; 1524-first conveyor belt; 153-third moving assembly; 1531-third drive; 1532-second slider; 1533-second guide rail; 1534-second conveyor belt; 154-wire feeder; 155-plastic wire. DETAILED DESCRIPTION

[0046] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Generally, the units of the embodiments of the present invention described and shown in the drawings herein can be arranged and designed in various different configurations.

[0047] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention as claimed, but rather merely represents selected embodiments of the present invention. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without creative effort are intended to fall within the scope of protection of the present invention.

[0048] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, it does not need to be further defined or explained in subsequent drawings.

[0049] In the description of the present invention, it should be noted that if the terms "upper", "lower", "inside", "outside", etc. appear, the orientation or position relationship indicated is based on the orientation or position relationship shown in the accompanying drawings, or is the orientation or position relationship in which the product of the invention is usually placed when in use. It is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it should not be understood as a limitation on the present invention.

[0050] In addition, the terms "first", "second", etc., if used, are merely used to distinguish and describe, and should not be understood as indicating or implying relative importance.

[0051] It should be noted that, in the absence of conflict, the features in the embodiments of the present invention may be combined with each other.

[0052] In existing in vitro animal experiments, manual sampling is typically performed using tools such as forceps or scissors. During the sampling process, the tissue is manually removed by the staff. However, this sampling method requires a lot of manpower, resulting in high labor costs and low efficiency.

[0053] Please refer to Figure 1 , Figure 1 This is a structural diagram of the animal ex vivo tissue sampling device 100 provided in this embodiment. It should be noted that the Z direction shown in the figure is the first direction, the X direction is the second direction, and the Y direction is the third direction; wherein the first direction, the second direction and the third direction are perpendicular to each other.

[0054] In order to solve the above technical problems, the present invention provides an animal ex vivo tissue sampling device 100, which includes a sampling needle 110, a frame 120, a sample carrier 130, a storage unit 140 and a movable unit 150; the sample carrier 130 is connected to the frame 120 and is used to place animal ex vivo tissue; the storage unit 140 is connected to the frame 120 and is used to store the sampling needle 110 and the sample; the movable unit 150 is movably connected to the frame 120 and is detachably connected to the sampling needle 110.

[0055] Specifically, before sampling begins, the sample target, i.e., ex vivo animal tissue, is placed in the sample carrier 130, and the sampling needle 110 is stored in the storage device. To begin sampling, the movable unit 150 is moved to the storage unit 140, connecting the movable unit 150 and the sampling needle 110. This then drives the sampling needle 110 to the sample carrier 130 to sample the ex vivo animal tissue in the sample carrier 130. After sampling is complete, the movable unit 150 drives the collected sample to the storage unit 140. After the sample is stored in the storage unit 140, the movable unit 150 is disconnected from the sample needle 110, which has collected the sample, and the sampling needle 110 is placed in the storage unit 140.

[0056] Therefore, the animal ex vivo tissue sampling device 100 in this embodiment can complete the task of collecting samples, and can also reconnect a new sampling needle 110 after placing the sampling needle 110 that has collected samples in the storage unit 140 to perform a new round of sampling.

[0057] The animal ex vivo tissue sampling device 100 in this embodiment utilizes a movable unit 150 to connect a sampling needle 110 to sample animal ex vivo tissue, and can automatically save the collected samples and recycle the sampling needle 110 that has collected samples, thereby realizing automated sampling of animal three-dimensional tissues, reducing labor costs, and improving sampling efficiency.

[0058] For further information, please refer to Figure 1-Figure 3 , Figure 2 A schematic structural diagram of the first moving member provided in this embodiment from a first viewing angle; Figure 3 This is a schematic structural diagram of the second moving member and the third moving member provided in this embodiment.

[0059] The movable unit 150 includes a first movable assembly 151 that is movably connected. The end of the first movable assembly 151 near the sample carrier 130 is detachably connected to the sampling needle 110, allowing the first movable assembly 151 to connect to an unused sampling needle 110 to drive the sampling needle 110 for sampling. The sampling needle 110 can also be removed after the sampling needle 110 completes sampling. Understandably, since the sample cannot completely detach from the sampling needle 110, some of the sample will still adhere to the end of the sampling needle 110. To prevent different samples from mixing and affecting the experimental structure, the sampling needle 110 is only used once. After sampling is completed, a new sample must be replaced to sample new animal tissue.

[0060] The movable components in this embodiment also include a second movable component 152 and a third movable component 153. The first movable component 151 is used to drive the sampling needle 110 to move along the first direction, the second movable component 152 is used to drive the sampling needle 110 to move along the second direction, and the third movable component 153 is used to drive the sampling needle 110 to move along the third direction.

[0061] Thus, the sampling needle 110 can move in three directions driven by the first moving component 151 , the second moving component 152 and the third moving component 153 , which is more flexible, facilitates the sampling needle 110 to quickly collect samples, and improves the sampling speed.

[0062] It should be noted that in this embodiment, the first and second directions are horizontal, driving the sampling needle 110 to switch between the sample carrier 130 and the storage unit 140. The first direction is vertical, and the sample carrier 130 is located below the first movable assembly 151. Therefore, when the first movable assembly 151 drives the sampling needle 110 downward, the sampling needle 110 gradually approaches the animal's ex vivo tissue, contacts it, and collects the sample. When the first movable assembly 151 drives the sampling needle 110 upward, the sampling needle 110 separates from the animal's ex vivo tissue and gradually moves away from the animal's ex vivo tissue.

[0063] Please refer to Figure 1-Figure 7 , Figure 4 A schematic diagram of the partial structure of the first moving member provided in this embodiment from a second viewing angle; Figure 5 for Figure 4 A partial enlarged view of point A in the middle; Figure 6 A schematic cross-sectional view of the sampling needle 110 provided in this embodiment in a sampling state; Figure 7 This is a cross-sectional schematic diagram of the sampling needle 110 provided in this embodiment in the withdrawn state.

[0064] Furthermore, in this embodiment, the first moving component 151 includes a chuck 1511 and a first driver 1512. The first driver 1512 is connected to the chuck 1511 to actuate the chuck 1511 to move along a first direction, so that the chuck 1511 has at least a first position and a second position; when the chuck 1511 is in the first position, the chuck 1511 is closed; when the chuck 1511 is in the second position, the chuck 1511 is open.

[0065] It can be understood that when the first driver 1512 drives the chuck 1511 to move from the first position to the second position, the chuck 1511 gradually opens, allowing the sampling needle 110 to extend into the chuck 1511. Subsequently, the chuck 1511 is again driven by the first driver 1512 to move from the second position to the first position, and the chuck 1511 gradually closes, thereby clamping the sampling needle 110. Thus, the first moving assembly 151 utilizes the opening and closing of the chuck 1511 to clamp the sampling needle 110 and remove the sampling needle 110 from the storage unit 140. Then, driven by the second moving assembly 152 and the third moving assembly 153, the sampling needle 110 is moved from the storage unit 140 to the sample carrier 130.

[0066] Specifically, the sampling needle 110 includes a body 111 and a push rod 112, with the body 111 being sleeved on the push rod 112. The first movable assembly 151 also includes a piston 1513 provided with a protrusion 1514, and the piston 1513 is connected to the body 111. It should be noted that the body 111 in this embodiment has a hollow structure, so that the push rod 112 can be sleeved on the body 111. The diameter of one end of the body 111 is larger than the diameter of the piston 1513, so that the piston 1513 can extend into the body 111 and abut against the inner wall of the body 111, thereby clamping the body 111 and the piston 1513 together, thereby enabling the first movable assembly 151 to drive the sampling needle 110 out of the storage unit 140. The other end of the body 111 is a blade for contacting and cutting animal tissue to obtain a sample.

[0067] The sampling needle 110 in this embodiment has four blades. In other embodiments, different types of sampling needles 110 can be selected according to actual needs.

[0068] In this embodiment, when the clamp 1511 moves from the first position to the second position, the clamp 1511 abuts against the protrusion 1514. As a result, the front end of the clamp 1511 gradually opens under the action of the protrusion 1514, allowing the push rod 112 to extend into the clamp 1511. Subsequently, the clamp 1511 moves from the first position to the second position, that is, gradually closes from the open state, thereby clamping the push rod 112.

[0069] It should be noted that the first moving assembly 151 in this embodiment further includes a motor 1516 , and the motor 1516 is used to drive the first driver 1512 , the chuck 1511 and the piston 1513 to move along the first direction.

[0070] The working principle of the first moving component 151 connecting to the sampling needle 111 in this embodiment is as follows:

[0071] First, the motor 1516 drives the first driver 1512, the chuck 1511, and the piston 1513 to move downward to approach the sampling needle 110 located in the storage unit 140. The piston 1513 has a through hole through which the push rod 112 in the sampling needle 110 can pass, thereby extending into the interior of the first moving assembly 151. At this time, there is still a certain distance between the body 111 of the sampling needle 110 and the piston 1513.

[0072] Next, the first driver 1512 drives the chuck 1511 downward from the first position to the second position, so that the chuck 1511 abuts against the protrusion 1514, opening the chuck 1511 and allowing the push rod 112 to extend into the chuck 1511. After the push rod 112 extends into the chuck 1511, the first driver 1512 drives the chuck 1511 upward, gradually disengaging the chuck 1511 from the protrusion 1514, and gradually closing the chuck 1511, so that the chuck 1511 can clamp the push rod 112.

[0073] Subsequently, after clamping the push rod 112, the clamping head 1511 continues to move upward to drive the push rod 112 to move upward relative to the body 111. Figure 6 When the lower end of the push rod 112 is at the extended blade, the sampling needle 110 is in the sampling state. At this time, the blade is in direct contact with the animal's ex vivo tissue. Therefore, the push rod 112 is driven to continue moving upward to enable the sampling needle 110 to enter the sampling state. When the sampling needle 110 is moved to the sample carrier 130, the sampling needle 110 can quickly complete the sampling of the animal's ex vivo tissue.

[0074] Finally, the motor 1516 drives the first driver 1512, the chuck 1511, and the piston 1513 to continue moving downward, so that the piston 1513 can engage with the body 111. After the piston 1513 and the body 111 are engaged, the motor 1516 drives the first driver 1512, the chuck 1511, the piston 1513, and the sampling needle 110 to move upward, thereby removing the sampling needle 110 from the storage unit 140.

[0075] It should be noted that, after the sampling is completed, the first movable member needs to remove the sampling needle 110 to store the sampling needle 110 in the storage unit 140; therefore, according to the above content, the first movable component 151 also includes a sleeve 1515, and the sleeve 1515 is sleeved on the chuck 1511; the sleeve 1515 is connected to the first driver 1512, and the first driver 1512 actuates the sleeve 1515 to move along the first direction to abut against the body 111.

[0076] The working principle of the first moving member unloading the sampling needle 110 is as follows:

[0077] First, after the sample is stored, the motor 1516 drives the sampling needle 110 to enter the corresponding storage position in the storage unit 140 .

[0078] Next, the first driver 1512 drives the clamp 1511 to move downward, thereby moving the clamp 1511 from the first position to the second position. The clamp 1511 contacts the protrusion 1514 and opens, thereby releasing the push rod 112 .

[0079] Moreover, while the first driver 1512 drives the chuck 1511 to move downward, the sleeve 1515 also moves downward under the drive of the first driver 1512, so that the sleeve 1515 is connected to the end of the body 111, and under the squeezing action of the sleeve 1515, the piston 1513 is separated from the body 111.

[0080] Finally, the body 111 and the push rod 112 enter the storage position of the storage unit 140 under the action of gravity.

[0081] After the sampling needle 110 is connected and before the sampling needle 110 is unloaded, the first movable member is moved from the storage unit 140 to the sample carrier 130 under the drive of the second movable member and the third movable member. Then, the motor 1516 drives the first driver 1512, the chuck 1511, the piston 1513 and the sampling needle 110 to move downward, so that the sampling needle 110 approaches the animal's ex vivo tissue and contacts the device, and the blade cuts the animal's ex vivo tissue to obtain a sample.

[0082] Subsequently, the motor 1516 drives the first driver 1512, the chuck 1511, the piston 1513, and the sampling needle 110 to move upward, so that the sampling needle 110 is separated from the animal tissue. Driven by the second and third moving members, the sampling needle 110 is moved from the sample carrier 130 to the storage unit 140.

[0083] Finally, the first driver 1512 drives the chuck 1511 to move downward, and the chuck 1511 drives the push rod 112 to move downward relative to the body 111, so that the push rod 112 can contact the sample, and under the push of the push rod 112, the sample is separated from the body 111 and stored in the storage unit 140.

[0084] Please refer to Figure 8 , Figure 8 Schematic diagram of the structure of the wire feeder 154 provided in other embodiments. In other embodiments, the movable unit 150 includes a wire feeder 154 and a plastic wire 155 , and the wire feeder 154 and the plastic wire 155 are movably connected; the plastic wire 155 is sleeved on the sampling needle 110.

[0085] It can be understood that in other embodiments, a plastic wire 155 can be used to replace the push rod 112 in this embodiment, and the wire feeder 154 can be used to drive the plastic wire 155 to move relative to the sampling needle 110, so that during the process of unloading the sampling needle 110, the body 111 of the sampling needle 110 can be directly unloaded without unloading the plastic wire 155.

[0086] However, before unloading the body 111 of the sampling needle 110 , since the front end of the plastic wire 155 will partially protrude relative to the body 111 , an automatic shearing mechanism is required to cut off the front end of the plastic wire 155 and then remove the sampling needle 110 .

[0087] The wire feeder 154 is provided with a gear assembly, so that the rotation of the gear assembly can drive the plastic wire 155 to expand and contract.

[0088] When the sample needs to be removed from the sampling needle body 111, the gear assembly rotates to extend the plastic filament 155, thereby contacting the sample and pushing it out. After the automatic shearing mechanism completes shearing the plastic filament 155, the gear assembly reverses to retract the plastic filament 155, causing the front end of the plastic filament 155 to return to the piston 1513.

[0089] Furthermore, the second moving component 152 includes a second driver 1521, a first slider 1522 and a first guide rail 1523. The second driver 1521 is connected to the first slider 1522 and is used to actuate the first slider 1522 to move along the second direction; the first slider 1522 is slidably engaged with the first guide rail 1523; the extension direction of the first guide rail 1523 is parallel to the second direction.

[0090] The third moving component 153 includes a third driver 1531, a second slider 1532 and a second guide rail 1533. The third driver 1531 is connected to the second slider 1532 and is used to actuate the second slider 1532 to move along the third direction; the second slider 1532 and the second guide rail 1533 are slidably matched, and the extension direction of the second guide rail 1533 is parallel to the third direction.

[0091] Specifically, in this embodiment, the second moving component 152 also includes a first conveyor belt 1524, which is connected to the second driver 1521 and the first slider 1522, so that the second driver 1521 can drive the first conveyor belt 1524 to move, and the third slider moves along the second direction under the drive of the first conveyor belt 1524.

[0092] Similarly, the third moving component 153 also includes a second conveyor belt 1534, which is connected to the third driver 1531 and the second slider 1532, so that the third driver 1531 can drive the second conveyor belt 1534 to move, and the second slider 1532 moves along the third direction under the drive of the second conveyor belt 1534.

[0093] The first slider 1522 , the first moving assembly 151 , and the second moving assembly 152 are disposed on a bracket, and the bracket is connected to the second slider 1532 , thereby driving the first moving assembly 151 to move in a horizontal direction.

[0094] In other embodiments, other sliding devices may be used to enable the first moving member to move in the horizontal direction.

[0095] Please refer to Figure 1-Figure 7 、 Figure 9 as well as Figure 10 , Figure 9 A schematic structural diagram of the storage unit 140 provided in this embodiment; Figure 10 Schematic diagram of the structure of the sample carrier 130 provided.

[0096] In this embodiment, the storage unit 140 includes a first sampling needle storage part 141, a second sampling needle storage part 142, a sample storage part 143 and a connecting plate 144; the first sampling needle storage part 141, the second sampling needle storage part 142 and the sample storage part 143 are all connected to the connecting plate 144; the connecting plate 144 is connected to the frame 120; the first sampling needle storage part 141 is used to store the sampling needle 110 before sampling, and the second sampling needle storage part 142 is used to store the sampling needle 110 after sampling.

[0097] It can be understood that the first movable part first takes out a new sampling needle 110 from the first sampling needle storage part 141, and after completing the sampling, stores the sample in the sample storage part 143, and then unloads the sampling needle 110 that has collected the sample and stores it in the second sampling needle storage part 142.

[0098] According to the above content, the first sampling needle storage member 141 is provided with multiple first accommodating holes 1411, and the second sampling needle storage member 142 is provided with multiple second accommodating holes 1421; each first accommodating hole 1411 corresponds to a second accommodating hole 1421; the sample storage member 143 is provided with multiple sample accommodating holes 1431, and each sample accommodating hole 1431 corresponds to a second accommodating hole 1421.

[0099] Furthermore, the sample carrier 130 is provided with a plurality of sampling holes 131 , and each sampling hole 131 corresponds to a sample receiving hole 1431 .

[0100] It should be noted that in this embodiment, each first receiving hole 1411, each second receiving hole 1421, each sample receiving hole 1431, and each sampling hole 131 are all numbered. For example, if a first receiving hole 1411 is numbered first receiving hole 1411, then the corresponding markings are second receiving hole 1421, sample receiving hole 1431, and sampling hole 131. Therefore, during the sampling process, the sampling needle 110 located in first receiving hole 1411 can sample the animal ex vivo tissue in sampling hole 131. The collected sample is placed in receiving hole 1, and the sampling needle 110 is finally stored in second receiving hole 1421.

[0101] Thus, this embodiment can avoid the reuse of the sampling needle 110 during the sampling process, which could affect experimental results. It can also be used to associate samples with isolated animal tissues during subsequent experiments, ensuring that the experimental results represent the specific animal tissues from which the results were obtained. Furthermore, if a problem with a sample occurs, the corresponding sampling needle 110 can be quickly inspected to determine if it is damaged, thus rendering the sample unqualified.

[0102] Furthermore, in this embodiment, the animal ex vivo tissue sampling device 100 is also provided with a control panel, which is electrically connected to the motor 1516, the first driver 1512, the second driver 1521 and the third driver 1531, so as to control the movement of the movable components to complete the sampling work.

[0103] In summary, an embodiment of the present invention provides an animal ex vivo tissue sampling device 100, which includes a sampling needle 110, a frame 120, a sample carrier 130, a storage unit 140 and a movable unit 150; the sample carrier 130, the sample carrier 130, the storage unit 140 and the movable unit 150 are all connected to the frame 120; the sampling needle 110 is detachably connected to the movable unit 150.

[0104] Before sampling, the sampling needle 110 is located in the storage unit 140. The movable unit 150 connects to the sampling needle 110 and moves it to the sample carrier 130, allowing the sampling needle 110 to sample the ex vivo animal tissue placed in the sample carrier 130. After sampling is completed, the movable unit 150 moves the sampling needle 110 back to the storage unit 140 to store the sample there. The movable unit 150 then removes the sampling needle 110 and stores the completed sampling needle 110 in the storage unit 140.

[0105] Therefore, this embodiment can realize automated sampling of animal ex vivo tissues, and can store samples and sampling needles 110, thereby reducing labor costs while improving sampling efficiency, and can also avoid contamination of collected samples, thereby improving the accuracy of the experiment.

[0106] The above description is only a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by any technician familiar with this technical field within the technical scope disclosed in the present invention should be covered by the scope of protection of the present invention.

Claims

1. An animal in vitro tissue sampling device, characterized in that: include: Sampling needle (110); Frame (120); A sample carrier (130), the sample carrier (130) is connected to the frame (120) and is used to place animal ex vivo tissue; a storage unit (140), the storage unit (140) being connected to the frame (120) and being used to store the sampling needle (110) and the sample; a movable unit (150), the movable unit (150) being movably connected to the frame (120) and detachably connected to the sampling needle (110); The movable unit (150) is used to connect the sampling needle (110) to the storage unit (140) and move to the sample carrier (130) to collect samples; and transfer the collected samples to the storage unit (140) for storage.

2. The animal ex vivo tissue sampling device according to claim 1, characterized in that: The movable unit (150) includes a first movable component (151), a second movable component (152), and a third movable component (153) that are movably connected. An end of the first movable component (151) close to the sample carrier (130) is detachably connected to the sampling needle (110). The first moving assembly (151) is used to drive the sampling needle (110) to move along a first direction, the second moving assembly (152) is used to drive the sampling needle (110) to move along a second direction, and the third moving assembly (153) is used to drive the sampling needle (110) to move along a third direction; The first direction, the second direction and the third direction are perpendicular to each other.

3. The animal ex vivo tissue sampling device according to claim 2, characterized in that: The first moving assembly (151) comprises a chuck (1511) and a first driver (1512), wherein the first driver (1512) is connected to the chuck (1511) to actuate the chuck (1511) to move along a first direction, and the chuck (1511) has at least a first position and a second position; When the chuck (1511) is located at the first position, the chuck (1511) is closed; when the chuck (1511) is located at the second position, the chuck (1511) is opened.

4. The animal ex vivo tissue sampling device according to claim 3, characterized in that: The first moving assembly (151) further includes a piston (1513) provided with a protrusion (1514); the sampling needle (110) includes a body (111) and a push rod (112), the body (111) being sleeved on the push rod (112); the piston (1513) and the body (111) are connected; When the clamp (1511) is located at the first position, the clamp (1511) clamps the push rod (112); when the clamp (1511) is located at the second position, the clamp (1511) abuts against the protrusion (1514).

5. The animal ex vivo tissue sampling device according to claim 4, characterized in that: The first moving component (151) further includes a sleeve (1515), which is sleeved on the chuck (1511); the sleeve (1515) is connected to the first driver (1512), and the first driver (1512) actuates the sleeve (1515) to move along the first direction to abut against the body (111).

6. The animal ex vivo tissue sampling device according to claim 2, characterized in that: The second moving assembly (152) comprises a second driver (1521), a first slider (1522) and a first guide rail (1523); the second driver (1521) is connected to the first slider (1522) and is used to actuate the first slider (1522) to move along the second direction; the first slider (1522) is in sliding engagement with the first guide rail (1523); the extension direction of the first guide rail (1523) is parallel to the second direction; The third moving assembly (153) comprises a third driver (1531), a second slider (1532) and a second guide rail (1533); the third driver (1531) is connected to the second slider (1532) and is used to actuate the second slider (1532) to move along the third direction; the second slider (1532) is slidably engaged with the second guide rail (1533); the extension direction of the second guide rail (1533) is parallel to the third direction; Wherein, the first slider (1522) is connected to the first moving component (151) and the second slider (1532).

7. The animal ex vivo tissue sampling device according to claim 1, characterized in that: The movable unit (150) comprises a wire feeder (154) and a plastic wire (155), wherein the wire feeder (154) is movably connected to the plastic wire (155); and the plastic wire (155) is sleeved on the sampling needle (110).

8. The animal ex vivo tissue sampling device according to any one of claims 1 to 7, characterized in that: The storage unit (140) includes a first sampling needle storage part (141), a second sampling needle storage part (142), a sample storage part (143) and a connecting plate (144); the first sampling needle storage part (141), the second sampling needle storage part (142) and the sample storage part (143) are all connected to the connecting plate (144); the connecting plate (144) is connected to the frame (120); The first sampling needle storage part (141) is used to store the sampling needle (110) before sampling, and the second sampling needle storage part (142) is used to store the sampling needle (110) after sampling.

9. The animal ex vivo tissue sampling device according to claim 8, characterized in that: The first sampling needle storage member (141) is provided with a plurality of first accommodating holes (1411), and the second sampling needle storage member (142) is provided with a plurality of second accommodating holes (1421); each first accommodating hole (1411) corresponds to one second accommodating hole (1421); The sample storage part (143) is provided with a plurality of sample accommodating holes (1431), and each of the sample accommodating holes (1431) corresponds to one of the second accommodating holes (1421).

10. The animal ex vivo tissue sampling device according to claim 9, characterized in that: The sample carrier (130) is provided with a plurality of sampling holes (131), and each of the sampling holes (131) corresponds to one of the sample accommodating holes (1431).

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